Brendan Jenkins

Research Interests

Cancer Cell Biology Cancer Therapy Gastroenterology and Hepatology Immunology Innate Immunity Oncology and Carcinogenesis Respiratory Diseases Solid Tumours Tumour Immunology

Prof Brendan Jenkins

Program Leader

SAIGENCI

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Program Head, Tumour Inflammation and ImmunotherapyGroup Head, Cancer and Immune Signalling LaboratorySAiGENCI – South Australian immunoGENomics Cancer Institutehttps://www.adelaide.edu.au/saigenci/our-research-programs/tumour-inflammation-and-immunotherapy#cancer-and-immune-signalling-laboratory-cisl--2Professor Brendan Jenkins completed his PhD studies at the Hanson Institute/University of Adelaide, before undertaking postdoctoral research at the world-renowned Fred Hutchinson Cancer Research Center in Seattle (USA), and later the Ludwig Institute for Cancer Research in Melbourne. In 2006, he established his own research group (Cancer and Immune Signalling Laboratory - CISL) at Hudson Institute of Medical Research, and in 2021 was appointed Director of the Centre for Innate Immunity and Infectious Diseases at the Hudson Institute. In 2023, he was recruited to join SAiGENCI (University of Adelaide) as Program Head of the Tumour Inflammation and Immunotherapy Program.Over the last 2 decades Professor Jenkins has been at the forefront of research examining the roles that innate immune cytokines, proteases and pattern recognition receptors (such as Toll-like receptors) play in the most common and lethal inflammation-associated cancers in the world, namely lung, stomach (gastric) and pancreatic cancers. In addition, his multidisciplinary research team investigates the role that these innate immune regulators play in driving chronic inflammatory conditions, in particular gastritis, emphysema/chronic obstructive pulmonary disease (COPD) and pancreatitis, which are also risk factors for the above-mentioned cancers. Collectively, his research programs incorporate long-standing collaborations with basic scientific researchers, industry and clinicians, both nationwide and overseas (UK, Japan, Singapore, Europe). Amongst his scientific achievements are publications in the highest-ranking science and medical research journals, including Cancer Cell, Nature Medicine, Nature, Immunity, Journal of Clinical Investigation, Journal of Experimental Medicine, Gut, Oncogene, Proceedings of the National Academy of Sciences USA, EMBO Molecular Medicine, Clinical Cancer Research and Cancer Research.In recognition of his research achievements, Professor Jenkins has held numerous fellowships (NHMRC RD Wright Postdoctoral Research Fellowship, Monash University Fellowship, Sylvia and Charles Viertel Senior Medical Research Fellowship, multiple NHMRC Senior Research Fellowships). His outstanding contributions to the medical research field have also been recognised by receiving many national and international awards, including the Australian Institute for Policy and Science Tall Poppy Award, and very recently the Annual International Cytokine and Interferon Society Distinguished Service Award. In addition, he has been awarded multiple project grants within Australia (NHMRC, Cancer Council) and overseas (United States Department of Defense, Association for International Cancer Research), is a regular invited speaker at local and international scientific meetings, and serves (including as Chair) on numerous committees and boards.

Date Position Institution name
2023 - ongoing Program Head University of Adelaide
2021 - 2023 Centre Director Hudson Institute of Medical Research

Year Citation
2024 Dawson, R. E., & Jenkins, B. J. (2024). The Role of Inflammasome-Associated Innate Immune Receptors in Cancer. Immune network, 24(5), e38-1-e38-23.
DOI Scopus9 WoS9 Europe PMC8
2024 Moghaddam, S. J., Savai, R., Salehi-Rad, R., Sengupta, S., Kammer, M. N., Massion, P., . . . Keith, R. L. (2024). Premalignant Progression in the Lung: Knowledge Gaps and Novel Opportunities for Interception of Non-Small Cell Lung Cancer. An Official American Thoracic Society Research Statement. American Journal of Respiratory and Critical Care Medicine, 210(5), 548-571.
DOI Scopus10 WoS8 Europe PMC8
2024 Alanazi, M., Weng, T., McLeod, L., Gearing, L. J., Smith, J. A., Kumar, B., . . . Jenkins, B. J. (2024). Cytosolic DNA sensor AIM2 promotes KRAS-driven lung cancer independent of inflammasomes. Cancer Science, 115(6), 1834-1850.
DOI Scopus9 WoS9 Europe PMC9
2024 Saad, M. I., & Jenkins, B. J. (2024). The Protease ADAM17 at the Crossroads of Disease: Revisiting its Significance in Inflammation, Cancer, and Beyond. The FEBS journal, 291(1), 10-24.
DOI Scopus25 WoS24 Europe PMC24
2023 Jenkins, B. J. (2023). Preface. Methods in Molecular Biology, 2691, v.
2023 Sellahewa, R., Moghaddam, S. M., Lundy, J., Jenkins, B. J., & Croagh, D. (2023). Circulating Tumor DNA Is an Accurate Diagnostic Tool and Strong Prognostic Marker in Pancreatic Cancer. Pancreas, 52(3), E188-E195.
DOI Scopus3 Europe PMC2
2023 Curran, C. S., Dougherty, E. J., Cui, X., Li, Y., Jeakle, M., Gamble, T., . . . Torabi-Parizi, P. (2023). Nicotinamide Antagonizes Lipopolysaccharide-Induced Hypoxic Cell Signals in Human Macrophages.. Journal of immunology (Baltimore, Md. : 1950), 211(2), 261-273.
DOI Europe PMC9
2023 Dawson, R. E., Deswaerte, V., West, A. C., Sun, E., Wray‐McCann, G., Livis, T., . . . Jenkins, B. J. (2023). The cytosolic DNA sensor AIM2 promotes Helicobacter‐induced gastric pathology via the inflammasome. Immunology and Cell Biology, 101(5), 444-457.
DOI Scopus9 WoS9 Europe PMC9
2023 Rose-John, S., Jenkins, B. J., Garbers, C., Moll, J. M., & Scheller, J. (2023). Targeting IL-6 trans-signalling: past, present and future prospects. Nature Reviews Immunology, 23(10), 666-681.
DOI Scopus337 WoS337 Europe PMC298
2023 Millrine, D., Cardus Figueras, A., Uceda Fernandez, J., Andrews, R., Szomolay, B., Cossins, B. C., . . . Jones, S. A. (2023). Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to Alu-like Retroelements. The Journal of Immunology, 211(2), 274-286.
DOI Scopus4 Europe PMC4
2022 Headland, S. E., Dengler, H. S., Xu, D., Teng, G., Everett, C., Ratsimandresy, R. A., . . . Wilson, M. S. (2022). Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma. Science Translational Medicine, 14(627), 1-15.
DOI Scopus38 Europe PMC39
2022 Yu, L., Cao, C., Li, X., Zhang, M., Gu, Q., Gao, H., . . . Li, J. (2022). Complete loss of miR-200 family induces EMT associated cellular senescence in gastric cancer. Oncogene, 41(1), 26-36.
DOI Scopus28 Europe PMC31
2022 Dawson, R. E., Deswaerte, V., West, A. C., Tang, K., West, A. J., Balic, J. J., . . . Jenkins, B. J. (2022). STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis. Gut, 71(8), 1515-1531.
DOI Scopus33 WoS32 Europe PMC29
2022 Alhayyani, S., McLeod, L., West, A. C., Balic, J. J., Hodges, C., Yu, L., . . . Jenkins, B. J. (2022). Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer. Oncogene, 41(6), 809-823.
DOI Scopus9 WoS9 Europe PMC9
2022 West, A. J., Deswaerte, V., West, A. C., Gearing, L. J., Tan, P., & Jenkins, B. J. (2022). Inflammasome-Associated Gastric Tumorigenesis Is Independent of the NLRP3 Pattern Recognition Receptor. Frontiers in Oncology, 12, 830350.
DOI Scopus9 Europe PMC8
2022 Man, S. M., & Jenkins, B. J. (2022). Context-dependent functions of pattern recognition receptors in cancer. Nature Reviews Cancer, 22(7), 397-413.
DOI Scopus99 WoS95 Europe PMC92
2022 Tang, K., McLeod, L., Livis, T., West, A. C., Dawson, R., Yu, L., . . . Jenkins, B. J. (2022). Toll-like Receptor 9 Promotes Initiation of Gastric Tumorigenesis by Augmenting Inflammation and Cellular Proliferation. Cellular and Molecular Gastroenterology and Hepatology, 14(3), 567-586.
DOI Scopus15 WoS15 Europe PMC14
2022 Ruwanpura, S. M., McLeod, L., Dousha, L. F., Seow, H. J., West, A. C., West, A. J., . . . Jenkins, B. J. (2022). Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema. Proceedings of the National Academy of Sciences, 119(36), 1-12.
DOI Scopus18 WoS16 Europe PMC16
2022 Saad, M. I., Weng, T., Lundy, J., Gearing, L. J., West, A. C., Harpur, C. M., . . . Jenkins, B. J. (2022). Blockade of the protease ADAM17 ameliorates experimental pancreatitis. Proceedings of the National Academy of Sciences of USA, 119(42), e2213744119-1-e2213744119-12.
DOI Scopus20 WoS17 Europe PMC16
2022 Shen, H., Lundy, J., Strickland, A. H., Harris, M., Swan, M., Desmond, C., . . . Croagh, D. (2022). KRAS G12D Mutation Subtype in Pancreatic Ductal Adenocarcinoma: Does It Influence Prognosis or Stage of Disease at Presentation?. Cells, 11(19), 3175.
DOI Scopus40 Europe PMC36
2022 Jenkins, B. J. (2022). IL-6 family cytokines: An updated perspective on their broad pathophysiology. Cytokine, 152, 155822.
DOI Scopus3 Europe PMC3
2021 Lundy, J., Harris, M., Zalcberg, J., Zimet, A., Goldstein, D., Gebski, V., . . . Croagh, D. (2021). EUS-FNA Biopsies to Guide Precision Medicine in Pancreatic Cancer: Results of a Pilot Study to Identify KRAS Wild-Type Tumours for Targeted Therapy. Frontiers in Oncology, 11, 1-13.
DOI Scopus6 Europe PMC6
2021 Croagh, D., Masoumi-Moghaddam, S., Lundy, J., Gao, H., Rathi, V., Swan, M., . . . Jenkins, B. (2021). The EUS molecular evaluation of pancreatic cancer: A prospective multicenter cohort trial. Endoscopic Ultrasound, 10(5), 335-343.
DOI Scopus7 Europe PMC5
2021 Lundy, J., Gearing, L. J., Gao, H., West, A. C., McLeod, L., Deswaerte, V., . . . Jenkins, B. J. (2021). TLR2 activation promotes tumour growth and associates with patient survival and chemotherapy response in pancreatic ductal adenocarcinoma. Oncogene, 40(41), 6007-6022.
DOI Scopus16 WoS13 Europe PMC13
2021 Lundy, J., Gao, H., Berry, W., Masoumi-Moghoddam, S., Jenkins, B. J., & Croagh, D. (2021). Targeted Transcriptome and <i>KRAS</i> Mutation Analysis Improve the Diagnostic Performance of EUS-FNA Biopsies in Pancreatic Cancer. Clinical Cancer Research, 27(21), 5900-5911.
DOI Scopus12 Europe PMC12
2021 Saad, M. I., McLeod, L., Hodges, C., Vlahos, R., Rose-John, S., Ruwanpura, S., & Jenkins, B. J. (2021). ADAM17 Deficiency Protects against Pulmonary Emphysema. American Journal of Respiratory Cell and Molecular Biology, 64(2), 183-195.
DOI Scopus21 WoS21 Europe PMC18
2021 Dawson, R. E., Jenkins, B. J., & Saad, M. I. (2021). IL-6 family cytokines in respiratory health and disease. Cytokine, 143, 1-10.
DOI Scopus40 WoS38 Europe PMC30
2021 Vannitamby, A., Saad, M. I., Aloe, C., Wang, H., Kumar, B., Vlahos, R., . . . Bozinovski, S. (2021). Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model. Cancers, 13(13), 1-16.
DOI Scopus17 WoS17 Europe PMC13
2020 Chonwerawong, M., Ferrand, J., Chaudhry, H. M., Higgins, C., Tran, L. S., Lim, S. S., . . . Ferrero, R. L. (2020). Innate Immune Molecule NLRC5 Protects Mice From Helicobacter-induced Formation of Gastric Lymphoid Tissue. Gastroenterology, 159(1), 169-182.e8.
DOI Scopus24 Europe PMC17
2020 Holokai, L., Chakrabarti, J., Lundy, J., Croagh, D., Adhikary, P., Richards, S. S., . . . Zavros, Y. (2020). Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma. Cancers, 12(12), 3816.
DOI Scopus85 Europe PMC78
2020 Balic, J. J., Saad, M. I., Dawson, R., West, A. J., McLeod, L., West, A. C., . . . Jenkins, B. J. (2020). Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease. The American Journal of Pathology, 190(6), 1256-1270.
DOI Scopus24 WoS19 Europe PMC20
2020 Saad, M. I., McLeod, L., Yu, L., Ebi, H., Ruwanpura, S., Sagi, I., . . . Jenkins, B. J. (2020). The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis. Carcinogenesis, 41(4), 527-538.
DOI Scopus26 WoS26 Europe PMC22
2020 Balic, J. J., White, C. L., Dawson, R., Gough, D., McCormack, M. P., & Jenkins, B. J. (2020). STAT3-driven hematopoiesis and lymphopoiesis abnormalities are dependent on serine phosphorylation. Cytokine, 130, 155059.
DOI Scopus5 WoS4 Europe PMC3
2019 Saad., Rose-John., & Jenkins. (2019). ADAM17: An Emerging Therapeutic Target for Lung Cancer. Cancers, 11(9), 1-28.
DOI Scopus70 WoS58 Europe PMC49
2019 Balic, J. J., Garama, D. J., Saad, M. I., Yu, L., West, A. C., West, A. J., . . . Jenkins, B. J. (2019). Serine-Phosphorylated STAT3 Promotes Tumorigenesis via Modulation of RNA Polymerase Transcriptional Activity. Cancer Research, 79(20), 5272-5287.
DOI Scopus30 WoS29 Europe PMC28
2019 Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M., Deswaerte, V., . . . Jenkins, B. J. (2019). ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.. EMBO molecular medicine, 11(4), 1-19.
DOI Scopus79 WoS75 Europe PMC67
2019 Han, T. -S., Voon, D. C. -C., Oshima, H., Nakayama, M., Echizen, K., Sakai, E., . . . Oshima, M. (2019). Interleukin 1 Up-regulates MicroRNA 135b to Promote Inflammation-Associated Gastric Carcinogenesis in Mice. Gastroenterology, 156(4), 1140-1155.
DOI Scopus51 WoS45 Europe PMC41
2019 Liu, Y. D., Yu, L., Ying, L., Balic, J., Gao, H., Deng, N. T., . . . Li, J. K. (2019). Toll-like receptor 2 regulates metabolic reprogramming in gastric cancer via superoxide dismutase 2. International Journal of Cancer, 144(12), 3056-3069.
DOI Scopus57 WoS53 Europe PMC45
2018 Berry, W., Lundy, J., Croagh, D., & Jenkins, B. J. (2018). Reviewing the utility of EUS FNA to advance precision medicine in pancreatic cancer. Cancers, 10(2), 15 pages.
DOI Scopus21 WoS20 Europe PMC19
2018 Hill, D. G., Yu, L., Gao, H., Balic, J. J., West, A., Oshima, H., . . . Jones, G. W. (2018). Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development. International Journal of Cancer, 143(1), 167-178.
DOI Scopus51 WoS47 Europe PMC43
2018 Tafreshi, M., Guan, J., Gorrell, R. J., Chew, N., Xin, Y., Deswaerte, V., . . . Kwok, T. (2018). Helicobacter pylori type IV secretion system and its adhesin subunit, CagL, mediate potent inflammatory responses in primary human endothelial cells. Frontiers in Cellular and Infection Microbiology, 8(FEB), 15 pages.
DOI Scopus32 WoS31 Europe PMC22
2018 Jenkins, B. J., & Deswaerte, V. (2018). Immuno-detection of immature and bioactive forms of the inflammatory cytokine IL-18. Methods in molecular biology (Clifton, N.J.), 1725, 229-235.
DOI
2018 Deswaerte, V., Nguyen, P., West, A., Browning, A. F., Yu, L., Ruwanpura, S. M., . . . Jenkins, B. J. (2018). Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism.. Cancer research, 78(5), 1293-1307.
DOI Scopus76 WoS67 Europe PMC57
2018 Jones, S. A., & Jenkins, B. J. (2018). Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer. Nature Reviews Immunology, 18(12), 773-789.
DOI Scopus902 WoS843 Europe PMC768
2018 Yu, L., Di, W., Gao, H., Balic, J., Tsykin, A., Han, T. -S., . . . Jenkins, B. (2018). Clinical utility of a STAT3-regulated miRNA-200 family signature with prognostic potential in early gastric cancer. Clinical Cancer Research, 24(6), 1459-1472.
DOI Scopus45 WoS41 Europe PMC38
2017 Jamsai, D., Watkins, D. N., O'Connor, A. E., Merriner, D. J., Gursoy, S., Bird, A. D., . . . O'Bryan, M. K. (2017). In vivo evidence that RBM5 is a tumour suppressor in the lung. Scientific Reports, 7(1), 16323-1-16323-8.
DOI Scopus27 WoS26 Europe PMC26
2017 Balic, J. J., Garbers, C., Rose-John, S., Yu, L., & Jenkins, B. J. (2017). Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling. Cytokine, 92, 118-123.
DOI Scopus25 WoS24 Europe PMC22
2017 West, A. C., Tang, K., Tye, H., Yu, L., Deng, N., Najdovska, M., . . . Jenkins, B. J. (2017). Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer. Oncogene, 36(36), 5134-5144.
DOI Scopus58 WoS55 Europe PMC46
2017 Jenkins, B. J. (2017). Potential efficacy of interleukin-1β inhibition in lung cancer. Lancet, 390(10105), 1813-1814.
DOI Scopus7 WoS5 Europe PMC5
2017 Deswaerte, V., Ruwanpura, S. M., & Jenkins, B. J. (2017). Transcriptional regulation of inflammasome-associated pattern recognition receptors, and the relevance to disease pathogenesis. Molecular Immunology, 86, 3-9.
DOI Scopus16 WoS13 Europe PMC11
2017 Miller, A., McLeod, L., Alhayyani, S., Szczepny, A., Watkins, D. N., Chen, W., . . . Jenkins, B. J. (2017). Blockade of the IL-6 trans-signalling/STAT3 axis suppresses cachexia in Kras-induced lung adenocarcinoma. Oncogene, 36(21), 3059-3066.
DOI Scopus75 WoS74 Europe PMC76
2017 Berry, W., Algar, E., Kumar, B., Desmond, C., Swan, M., Jenkins, B. J., & Croagh, D. (2017). Endoscopic ultrasound-guided fine-needle aspirate-derived preclinical pancreatic cancer models reveal panitumumab sensitivity in KRAS wild-type tumors. International Journal of Cancer, 140(10), 2331-2343.
DOI Scopus39 WoS35 Europe PMC32
2016 Jenkins, B. J. (2016). Multifaceted Role of IRAK-M in the Promotion of Colon Carcinogenesis via Barrier Dysfunction and STAT3 Oncoprotein Stabilization in Tumors. Cancer Cell, 29(5), 615-617.
DOI Scopus3 WoS3 Europe PMC3
2016 Maeda, Y., Echizen, K., Oshima, H., Yu, L., Sakulsak, N., Hirose, O., . . . Oshima, M. (2016). Myeloid differentiation factor 88 signaling in bone marrow-derived cells promotes gastric tumorigenesis by generation of inflammatory microenvironment. Cancer Prevention Research, 9(3), 253-263.
DOI Scopus26 WoS21 Europe PMC21
2016 Brooks, G. D., McLeod, L., Alhayyani, S., Miller, A., Russell, P. A., Ferlin, W., . . . Jenkins, B. J. (2016). IL6 trans-signaling promotes KRAS-driven lung carcinogenesis. Cancer Research, 76(4), 866-876.
DOI Scopus102 WoS98 Europe PMC90
2016 Walker, E. C., Johnson, R. W., Hu, Y., Brennan, H. J., Poulton, I. J., Zhang, J. G., . . . Sims, N. A. (2016). Murine oncostatin m acts via leukemia inhibitory factor receptor to phosphorylate signal transducer and activator of transcription 3 (STAT3) but not STAT1, an effect that protects bone mass. Journal of Biological Chemistry, 291(41), 21703-21716.
DOI Scopus47 WoS43 Europe PMC41
2016 Ruwanpura, S. M., McLeod, L., Dousha, L. F., Seow, H. J., Alhayyani, S., Tate, M. D., . . . Jenkins, B. J. (2016). Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema. American Journal of Respiratory and Critical Care Medicine, 194(12), 1494-1505.
DOI Scopus45 WoS40 Europe PMC38
2015 Jones, G. W., Bombardieri, M., Greenhill, C. J., McLeod, L., Nerviani, A., Rocher-Ros, V., . . . Jones, S. A. (2015). Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis. Journal of Experimental Medicine, 212(11), 1793-1802.
DOI Scopus92 WoS87 Europe PMC81
2015 Miller, A., Brooks, G. D., McLeod, L., Ruwanpura, S., & Jenkins, B. J. (2015). Differential involvement of gp130 signalling pathways in modulating tobacco carcinogen-induced lung tumourigenesis. Oncogene, 34(12), 1510-1519.
DOI Scopus17 WoS15 Europe PMC14
2015 Bozinovski, S., Seow, H. J., Chan, S. P. J., Anthony, D., McQualter, J., Hansen, M., . . . Vlahos, R. (2015). Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarettesmoke- induced lung inflammation in mice. Clinical Science, 129(9), 785-796.
DOI Scopus70 WoS68 Europe PMC62
2015 West, A. C., & Jenkins, B. J. (2015). Inflammatory and non-inflammatory roles for toll-like receptors in gastrointestinal cancer. Current Pharmaceutical Design, 21(21), 2968-2977.
DOI Scopus21 WoS20 Europe PMC16
2015 Jones, G. W., McLeod, L., Kennedy, C. L., Bozinovski, S., Najdovska, M., & Jenkins, B. J. (2015). Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis. Atherosclerosis, 238(2), 321-328.
DOI Scopus16 WoS13 Europe PMC13
2014 Kennedy, C. L., Najdovska, M., Tye, H., McLeod, L., Yu, L., Jarnicki, A., . . . Jenkins, B. J. (2014). Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis. Oncogene, 33(19), 2540-2546.
DOI Scopus42 WoS37 Europe PMC36
2014 Marusawa, H., & Jenkins, B. J. (2014). Inflammation and gastrointestinal cancer: An overview. Cancer Letters, 345(2), 153-156.
DOI Scopus57 WoS48 Europe PMC39
2014 Ruwanpura, S. M., McLeod, L., Brooks, G. D., Bozinovski, S., Vlahos, R., Longano, A., . . . Jenkins, B. J. (2014). IL-6/Stat3-driven pulmonary inflammation, but not emphysema, is dependent on interleukin-17A in mice. Respirology, 19(3), 419-427.
DOI Scopus21 WoS19 Europe PMC16
2014 Jenkins, B. J. (2014). Transcriptional regulation of pattern recognition receptors by JAK/STAT signaling, and the implications for disease pathogenesis. Journal of Interferon and Cytokine Research, 34(10), 750-758.
DOI Scopus18 WoS16 Europe PMC15
2014 Luu, K., Greenhill, C. J., Majoros, A., Decker, T., Jenkins, B. J., & Mansell, A. (2014). STAT1 plays a role in TLR signal transduction and inflammatory responses. Immunology and Cell Biology, 92(9), 761-769.
DOI Scopus128 WoS128 Europe PMC116
2014 Luo, L., Wall, A. A., Yeo, J. C., Condon, N. D., Norwood, S. J., Schoenwaelder, S., . . . Stow, J. L. (2014). Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling. Nature Communications, 5(1), 13 pages.
DOI Scopus113 WoS107 Europe PMC99
2014 Fielding, C. A., Jones, G. W., McLoughlin, R. M., McLeod, L., Hammond, V. J., Uceda, J., . . . Jones, S. A. (2014). Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity, 40(1), 40-50.
DOI Scopus316 WoS304 Europe PMC295
2013 Carow, B., Reuschl, A. K., Gavier-Widén, D., Jenkins, B. J., Ernst, M., Yoshimura, A., . . . Rottenberg, M. E. (2013). Critical and Independent Role for SOCS3 in Either Myeloid or T Cells in Resistance to Mycobacterium tuberculosis. Plos Pathogens, 9(7), 20 pages.
DOI Scopus36 WoS35 Europe PMC34
2013 Jones, G. W., Greenhill, C. J., Williams, J. O., Nowell, M. A., Williams, A. S., Jenkins, B. J., & Jones, S. A. (2013). Exacerbated inflammatory arthritis in response to hyperactive gp130 signalling is independent of IL-17A. Annals of the Rheumatic Diseases, 72(10), 1738-1742.
DOI Scopus22 WoS18 Europe PMC17
2013 Mansell, A., & Jenkins, B. J. (2013). Dangerous liaisons between interleukin-6 cytokine and toll-like receptor families: A potent combination in inflammation and cancer. Cytokine and Growth Factor Reviews, 24(3), 249-256.
DOI Scopus41 WoS31 Europe PMC28
2013 Allison, C. C., Ferrand, J., McLeod, L., Hassan, M., Kaparakis-Liaskos, M., Grubman, A., . . . Ferrero, R. L. (2013). Nucleotide oligomerization domain 1 enhances IFN-γ signaling in gastric epithelial cells during Helicobacter pylori infection and exacerbates disease severity. Journal of Immunology, 190(7), 3706-3715.
DOI Scopus59 WoS56 Europe PMC51
2013 Ruwanpura, S. M., McLeod, L., Lilja, A. R., Brooks, G., Dousha, L. F., Seow, H. J., . . . Jenkins, B. J. (2013). Non-essential role for TLR2 and its signaling adaptor Mal/TIRAP in preserving normal lung architecture in mice.. Plos One, 8(10), 9 pages.
DOI Scopus7 WoS8 Europe PMC7
2013 Tye, H., & Jenkins, B. J. (2013). Tying the knot between cytokine and toll-like receptor signaling in gastrointestinal tract cancers. Cancer Science, 104(9), 1139-1145.
DOI Scopus33 WoS28 Europe PMC21
2012 McCormack, W., Oshima, M., Tan, P., & Jenkins, B. J. (2012). Toll-like receptor 2: Therapeutic target for gastric carcinogenesis. Oncotarget, 3(11), 1260-1261.
DOI Scopus6 WoS6 Europe PMC6
2012 Tye, H., Kennedy, C. L., Najdovska, M., McLeod, L., McCormack, W., Hughes, N., . . . Jenkins, B. J. (2012). STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation. Cancer Cell, 22(4), 466-478.
DOI Scopus253 WoS240 Europe PMC216
2012 Greenhill, C. J., Gould, J., Ernst, M., Jarnicki, A., Hertzog, P. J., Mansell, A., & Jenkins, B. J. (2012). LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling. Immunology and Cell Biology, 90(5), 559-563.
DOI Scopus13 WoS13 Europe PMC15
2012 Ruwanpura, S. M., McLeod, L., Miller, A., Jones, J., Vlahos, R., Ramm, G., . . . Jenkins, B. J. (2012). Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice. American Journal of Physiology Lung Cellular and Molecular Physiology, 302(7), L627-L639.
DOI Scopus39 WoS35 Europe PMC40
2011 Jones, G. W., Stumhofer, J. S., Foster, T., Twohig, J. P., Hertzog, P., Topley, N., . . . Jones, S. A. (2011). Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB Journal, 25(1), 409-419.
DOI Scopus47 WoS45 Europe PMC45
2011 Greenhill, C. J., Rose-John, S., Lissilaa, R., Ferlin, W., Ernst, M., Hertzog, P. J., . . . Jenkins, B. J. (2011). IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3. Journal of Immunology, 186(2), 1199-1208.
DOI Scopus242 WoS242 Europe PMC223
2011 Ruwanpura, S. M., McLeod, L., Miller, A., Jones, J., Bozinovski, S., Vlahos, R., . . . Jenkins, B. J. (2011). Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice. American Journal of Respiratory Cell and Molecular Biology, 45(4), 720-730.
DOI Scopus61 WoS65 Europe PMC59
2011 Kennedy, C. L., Najdovska, M., Jones, G. W., McLeod, L., Hughes, N. R., Allison, C., . . . Jenkins, B. J. (2011). The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17. Journal of Pathology, 225(2), 255-264.
DOI Scopus31 WoS29 Europe PMC27
2010 Mejías-Luque, R., Lindén, S. K., Garrido, M., Tye, H., Najdovska, M., Jenkins, B. J., . . . De Bolós, C. (2010). Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors. Oncogene, 29(12), 1753-1762.
DOI Scopus69 WoS65 Europe PMC58
2009 Nowell, M. A., Williams, A. S., Carty, S. A., Scheller, J., Hayes, A. J., Jones, G. W., . . . Jones, S. A. (2009). Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. Journal of Immunology, 182(1), 613-622.
DOI Scopus176 WoS177 Europe PMC167
2008 Ernst, M., Najdovska, M., Grail, D., Lundgren-May, T., Buchert, M., Tye, H., . . . Jenkins, B. J. (2008). STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. Journal of Clinical Investigation, 118(5), 1727-1738.
DOI Scopus324 WoS305 Europe PMC276
2008 Fielding, C. A., McLoughlin, R. M., McLeod, L., Colmont, C. S., Najdovska, M., Grail, D., . . . Jenkins, B. J. (2008). IL-6 regulates neutrophil trafficking during acute inflammation via STAT3. Journal of Immunology, 181(3), 2189-2195.
DOI Scopus350 WoS333 Europe PMC322
2007 Brender, C., Tannahill, G. M., Jenkins, B. J., Fletcher, J., Columbus, R., Saris, C. J. M., . . . Starr, R. (2007). Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27. Blood, 110(7), 2528-2536.
DOI Scopus52 WoS50 Europe PMC47
2007 Jenkins, B. J., Roberts, A. W., Greenhill, C. J., Najdovska, M., Lundgren-May, T., Robb, L., . . . Ernst, M. (2007). Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis. Blood, 109(6), 2380-2388.
DOI Scopus75 WoS71 Europe PMC66
2006 Judd, L. M., Bredin, K., Kalantzis, A., Jenkins, B. J., Ernst, M., & Giraud, A. S. (2006). STAT3 Activation Regulates Growth, Inflammation, and Vascularization in a Mouse Model of Gastric Tumorigenesis. Gastroenterology, 131(4), 1073-1085.
DOI Scopus118 WoS113 Europe PMC102
2005 Jenkins, B. J., Grail, D., Nheu, T., Najdovska, M., Wang, B., Waring, P., . . . Ernst, M. (2005). Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling. Nature Medicine, 11(8), 845-852.
DOI Scopus273 WoS263 Europe PMC248
2005 McLoughlin, R. M., Jenkins, B. J., Grail, D., Williams, A. S., Fielding, C. A., Parker, C. R., . . . Jones, S. A. (2005). IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proceedings of the National Academy of Sciences of the United States of America, 102(27), 9589-9594.
DOI Scopus276 WoS269 Europe PMC256
2005 Howlett, M., Judd, L. M., Jenkins, B., La Gruta, N. L., Grail, D., Ernst, M., & Giraud, A. S. (2005). Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130. Gastroenterology, 129(3), 1005-1018.
DOI Scopus57 WoS53 Europe PMC48
2005 Sims, N. A., Jenkins, B. J., Nakamura, A., Quinn, J. M. W., Li, R., Gillespie, M. T., . . . Martin, T. J. (2005). Interleukin-11 receptor signaling is required for normal bone remodeling. Journal of Bone and Mineral Research, 20(7), 1093-1102.
DOI Scopus145 WoS135 Europe PMC117
2005 Jenkins, B. J., Roberts, A. W., Najdovska, M., Grail, D., & Ernst, M. (2005). The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis. Blood, 105(9), 3512-3520.
DOI Scopus75 WoS70 Europe PMC66
2004 Judd, L. M., Alderman, B. M., Howlett, M., Shulkes, A., Dow, C., Moverley, J., . . . Giraud, A. S. (2004). Gastric Cancer Development in Mice Lacking the SHP2 Binding Site on the IL-6 Family Co-receptor gp130. Gastroenterology, 126(1 SUPPL. 1), 196-207.
DOI Scopus164 WoS148 Europe PMC139
2004 Jenkins, B. J., Grail, D., Inglese, M., Quilici, C., Bozinovski, S., Wong, P., & Ernst, M. (2004). Imbalanced gp130-Dependent Signaling in Macrophages Alters Macrophage Colony-Stimulating Factor Responsiveness via Regulation of c-fms Expression. Molecular and Cellular Biology, 24(4), 1453-1463.
DOI Scopus38 WoS38 Europe PMC39
2004 Ernst, M., & Jenkins, B. J. (2004). Acquiring signalling specificity from the cytokine receptor gp130. Trends in Genetics, 20(1), 23-32.
DOI Scopus268 WoS255 Europe PMC230
2004 Sims, N. A., Jenkins, B. J., Quinn, J. M. W., Nakamura, A., Glatt, M., Gillespie, M. T., . . . Martin, T. J. (2004). Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways. Journal of Clinical Investigation, 113(3), 379-389.
DOI Scopus175 WoS161 Europe PMC136
2004 Sims, N. A., Jenkins, B. J., Quinn, J. M. W., Nakamura, A., Glatt, M., Gillespie, M. T., . . . Martin, T. J. (2004). Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways. Journal of Clinical Investigation, 113(3), 379-389.
DOI
2003 Mourtada-Maarabouni, M., Kirkham, L., Jenkins, B., Rayner, J., Gonda, T., Starr, R., . . . Williams, G. (2003). Functional expression cloning reveals proapoptotic role for protein phosphatase 4. Cell Death and Differentiation, 10(9), 1016-1024.
DOI Scopus40 WoS39 Europe PMC36
2002 Blake, T., Jenkins, B., D'Andrea, R., & Gonda, T. (2002). Functional cross-talk between cytokine receptors revealed by activating mutations in the extracellular domain of the β-subunit of the GM-CSF receptor. Journal of Leukocyte Biology, 72(6), 1246-1255.
DOI Scopus37 WoS35 Europe PMC25
2002 Tebbutt, N. C., Giraud, A. S., Inglese, M., Jenkins, B., Waring, P., Clay, F. J., . . . Ernst, M. (2002). Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nature Medicine, 8(10), 1089-1097.
DOI Scopus435 WoS407 Europe PMC359
2002 Jenkins, B. J., Quilici, C., Roberts, A. W., Grail, D., Dunn, A. R., & Ernst, M. (2002). Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling. Experimental Hematology, 30(11), 1248-1256.
DOI Scopus25 WoS21 Europe PMC18
2002 Wolf, I., Jenkins, B. J., Liu, Y., Seiffert, M., Custodio, J. M., Young, P., & Rohrschneider, L. R. (2002). Gab3, a new DOS/Gab family member, facilitates macrophage differentiation. Molecular and Cellular Biology, 22(1), 231-244.
DOI Scopus79 Europe PMC67
2001 Liu, Y., Jenkins, B., Jun Lim Shin., & Rohrschneider, L. R. (2001). Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase. Molecular and Cellular Biology, 21(9), 3047-3056.
DOI Scopus84 Europe PMC75
1999 Jenkins, B., Le, F., & Gonda, T. (1999). A cell type-specific constitutive point mutant of the common β-subunit of the human granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5 receptors requires the GM-CSF receptor α-subunit for activation. Journal of Biological Chemistry, 274(13), 8669-8677.
DOI Scopus17 WoS17 Europe PMC12
1998 Jenkins, B., Blake, T., & Gonda, T. (1998). Saturation mutagenesis of the β subunit of the human GM-CSF receptor shows clustering of constitutive mutations, activation of ERK MAP kinase and STAT pathways, and differential β subunit tyrosine phosphorylation. Blood, 92(6), 1989-2002.
DOI Scopus36
1998 Jenkins, B. J., Blake, T. J., & Gonda, T. J. (1998). Saturation mutagenesis of the β subunit of the human granulocyte-macrophage colony-stimulating factor receptor shows clustering of constitutive mutations, activation of ERK MAP kinase and STAT pathways, and differential β subunit tyrosine phosphorylation. BLOOD, 92(6), 1989-2002.
DOI WoS34 Europe PMC21
1997 Starr, R., Willson, T., Viney, E., Murray, L., Rayner, J., Jenkins, B., . . . Hilton, D. (1997). A family of cytokine-inducible inhibitors of signalling.. Nature, 387(6636), 917-921.
DOI Scopus1884 WoS1810 Europe PMC1523
1996 Jenkins, B., Bagley, C., Woodcock, J., Lopez, A., & Gonda, T. (1996). Interacting residues ion the extracellular region of the common β subunit of the human granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptors involved in constitutive activation. Journal of Biological Chemistry, 271(47), 29707-29714.
DOI Scopus22 WoS22 Europe PMC20
1995 Jenkins, B., D'Andrea, R., & Gonda, T. (1995). Activating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signalling. EMBO Journal, 14(17), 4276-4287.
DOI Scopus76 WoS78 Europe PMC46
1994 Jenkins, B. J., & Powell, B. C. (1994). Differential expression of genes encoding a cysteine-rich keratin family in the hair cuticle. Journal of Investigative Dermatology, 103(3), 310-317.
DOI Scopus36 WoS33 Europe PMC24
1992 Jenkins, B. J., & Powell, B. C. (1992). Isolation and characterization of a sheep cysteine-rich cuticle keratin pseudogene. Mitochondrial DNA, 3(3), 181-184.
DOI Scopus1 Europe PMC1

Year Citation
2024 Weng, T., Jenkins, B. J., & Saad, M. I. (2024). Patient-Derived Xenografts: A Valuable Preclinical Model for Drug Development and Biomarker Discovery (Vol. 2806). M. I. Saad (Ed.), Springer Nature.
DOI
2023 Jenkins, B. J. (2023). Inflammation and Cancer Methods and Protocols. Springer Nature.
2021 Research and Clinical Applications of Targeting Gastric Neoplasms (2021). . Academic Press.
DOI
2021 Research and Clinical Applications of Targeting Gastric Neoplasms (2021). . Academic Press.
DOI
2018 Jenkins, B. J. (2018). Inflammation and Cancer Methods and Protocols. Humana Press.

Year Citation
2023 Saad, M. I., & Jenkins, B. J. (2023). An In Vitro Model for Assessing Acute Lung Injury During Pancreatitis Development Using Primary Mouse Cell Co-cultures. In B. J. Jenkins (Ed.), Inflammation and Cancer : Methods and Protocols (Vol. 2691, 2nd ed. ed., pp. 71-80). Springer Nature : Humana Press.
DOI Scopus1 Europe PMC1
2023 Saad, M. I., & Jenkins, B. J. (2023). An In Vitro Model for Assessing Acute Lung Injury During Pancreatitis Development Using Primary Mouse Cell Co-cultures. In B. J. Jenkins (Ed.), Inflammation and Cancer : Methods and Protocols (Vol. 2691, 2nd ed. ed., pp. 71-80). Springer Nature : Humana Press.
DOI Scopus1 Europe PMC1
2021 Lundy, J., Saad, M., & Jenkins, B. (2021). A Method for the Establishment of Human Lung Adenocarcinoma Patient-Derived Xenografts in Mice. In P. G. Santiago-Cardona (Ed.), Lung Cancer. Methods and Molecular Biology (Vol. 2279, pp. 165-173). Humana Press.
DOI Scopus3 Europe PMC1
2021 Dawson, R., & Jenkins, B. J. (2021). Unravelling the pro-tumorigenic role of innate immune pattern recognition receptors in the gastric compartment. In Research and Clinical Applications of Targeting Gastric Neoplasms (pp. 43-90). Elsevier.
DOI
2017 Li, J. K., Balic, J. J., Yu, L., & Jenkins, B. (2017). TLR agonists as adjuvants for cancer vaccines. In D. Xu (Ed.), Regulation of Inflammatory Signaling in Health and Disease (Vol. 1024, pp. 195-212). New York City, NY, USA: Springer Nature.
DOI Scopus41 Europe PMC28
2016 West, A. C., & Jenkins, B. J. (2016). Investigating the role of Toll-like receptors in mouse models of gastric cancer. In Methods in Molecular Biology (Vol. 1390, pp. 427-449). Springer New York.
DOI Scopus3 Europe PMC2
2016 Dhagat, U., Nero, T. L., Kan, W. L., Hercus, T. R., Broughton, S. E., de Weerd, N. A., . . . Parker, M. W. (2016). Cytokine Receptors and Their Ligands. In R. A. Bradshaw, & P. D. Stahl (Eds.), Encyclopedia of Cell Biology (Vol. 3, pp. 22-36). US: Academic Press.
DOI

Year Citation
2025 Jenkins, B. J. (2025). Innate Immune Pattern Recognition Receptors as Drivers of Inflammation-associated Cancers. In CANCER SCIENCE Vol. 116 (pp. 623). WILEY.
1998 McCormack, M. P., Jenkins, B. J., & Gonda, T. J. (1998). Activated mutants of the human gm-csf receptor β subunit cause myeloproliferative disorders and leukaemia in mice. In Experimental Hematology Vol. 26 (pp. 754). CARDEN JENNINGS PUBL CO LTD.

Year Citation
2024 Derrac Soria, A., Lewis, M., Liu, X., Twohig, J., Monaco, F., Dimonte, S., . . . Jones, S. (2024). IL-6 and IL-27 negatively regulate CRTAM-expressing CD4<sup>+</sup>T-cells associated with lymphoid-driven synovitis.
DOI
2022 Millrine, D., Figueras, A. C., Fernandez, J. U., Andrews, R., Szomolay, B., Cossins, B., . . . Jones, S. (2022). Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to<i>Alu</i>-like retroelements.
DOI
2020 li, Y., ji, C., liu, Y., gu, Q., Jenkins, B., li, J., & yu, L. (2020). Activation of Toll-like receptor 2 via specific agonists promotes OXPHOS and glycolysis in gastric cancer cells rather than other Toll-like receptors.
DOI

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Co-Supervisor Investigating the rhomboid family of pseudoproteases (iRhoms) as potential therapeutic targets in lung cancer Master of Philosophy (Medical Science) Master Full Time Dr Shermin Yu Tung Chan
2025 Co-Supervisor Investigating the ADAM family of proteases as potential therapeutic targets in small cell lung cancer Master of Philosophy (Medical Science) Master Full Time Mrs Heba Mohamed Abdelazim Khattab
2025 Co-Supervisor Investigating the ADAM family of proteases as potential therapeutic targets in small cell lung cancer - Master Full Time Mrs Heba Mohamed Abdelazim Khattab
2025 Co-Supervisor Investigating the rhomboid family of pseudoproteases (iRhoms) as potential therapeutic targets in lung cancer - Master Full Time Dr Shermin Yu Tung Chan

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