| 2026 |
Zhou, A., Karhunen, V., Tian, H., Pott, J., Patel, A., Slob, E. A. W., & Burgess, S. (2026). Variant selection to maximize variance explained in cis-Mendelian randomization. Human Genetics and Genomics Advances, 7(2), 100573.
DOI |
| 2025 |
Hyppönen, E., Mulugeta, A., & Zhou, A. (2025). Reply to F. Hamilton and G. Davey Smith. American Journal of Clinical Nutrition, 122(3), 892-893.
DOI |
| 2025 |
Hyppönen, E., & Zhou, A. (2025). Non-linear Mendelian randomization analyses on 25-hydroxyvitamin D and the risk of cardiovascular outcomes. European Heart Journal, 46(44), 4843-4844.
DOI Scopus1 WoS1 |
| 2025 |
Hyppönen, E., Mulugeta, A., & Zhou, A. (2025). Reanalysis of the vitamin D and dementia association using the doubly-ranked nonlinear Mendelian randomization approach. The American Journal of Clinical Nutrition, 122(3), 894-897.
DOI Scopus1 WoS1 |
| 2025 |
Zhou, A., & Hyppönen, E. (2025). A reanalysis of the bidirectional association between vitamin D and C-reactive protein using the doubly-ranked non-linear Mendelian randomization approach. International Journal of Epidemiology, 54(5, article no. dyaf166), 1-5.
DOI Scopus1 Europe PMC1 |
| 2025 |
Sutherland, J. P., Zhou, A., & Hyppönen, E. (2025). Vitamin D, C-reactive protein, and increased fall risk: a genetic epidemiological study. Nutrients, 17(1), 1-16.
DOI Scopus2 WoS2 Europe PMC1 |
| 2025 |
Pham, K., Assefa Kassaw, N., Mulugeta, A., Zhou, A., & Hyppönen, E. (2025). Coffee and health outcomes: a systematic review of Mendelian randomisation studies. Nutrition Research Reviews, 38(2), 1006-1026.
DOI |
| 2024 |
Hypponen, E., Sutherland, J. P., & Zhou, A. (2024). Vitamin D deficiency increases mortality risk in the UK Biobank. Annals Of Internal Medicine, 177(12), 1743-1746.
DOI WoS2 |
| 2024 |
Kassaw, N. A., Zhou, A., Mulugeta, A., Lee, S. H., Burgess, S., & Hyppönen, E. (2024). Alcohol consumption and the risk of all-cause and cause-specific mortality-a linear and nonlinear Mendelian randomization study. International Journal of Epidemiology, 53(2), 1-8.
DOI Scopus18 WoS17 Europe PMC15 |
| 2024 |
Burgess, S., Sun, Y. Q., Zhou, A., Buck, C., Mason, A. M., & Mai, X. M. (2024). Body mass index and all-cause mortality in HUNT and UK biobank studies: revised non-linear Mendelian randomisation analyses. BMJ Open, 14(5), 1-11.
DOI Scopus8 Europe PMC11 |
| 2024 |
Burgess, S., & Zhou, A. (2024). Genetic predictors of traits in elderly subjects: risk of survival bias and reverse causation. European heart journal, 45(24), 2155-2157.
DOI Scopus4 Europe PMC2 |
| 2024 |
Hyppönen, E., Sutherland, J. P., & Zhou, A. (2024). IN RESPONSE. Annals of Internal Medicine, 177(12), 1743-1746.
DOI Scopus5 WoS4 Europe PMC2 |
| 2023 |
Zhou, A., & Hyppönen, E. (2023). Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study. International journal of epidemiology, 52(1), 260-271.
DOI Scopus87 WoS86 Europe PMC74 |
| 2023 |
Sutherland, J. P., Zhou, A., & Hyppönen, E. (2023). Muscle traits, sarcopenia, and sarcopenic obesity: a vitamin D Mendelian randomization study. Nutrients, 15(12), 1-13.
DOI Scopus17 WoS13 Europe PMC12 |
| 2022 |
Navale, S. S., Mulugeta, A., Zhou, A., Llewellyn, D. J., & Hyppönen, E. (2022). Vitamin D and brain health: an observational and Mendelian randomization study. The American Journal of Clinical Nutrition, 116(2), 531-540.
DOI Scopus72 WoS66 Europe PMC61 |
| 2022 |
Sutherland, J. P., Zhou, A., & Hyppönen, E. (2022). Vitamin D deficiency increases mortality risk in the UK biobank: a nonlinear Mendelian Randomization Study. Annals of Internal Medicine, 175(11), 1552-1559.
DOI Scopus103 WoS97 Europe PMC91 |
| 2022 |
Hyppönen, E., Vimaleswaran, K. S., & Zhou, A. (2022). Genetic determinants of 25-hydroxyvitamin D concentrations and their relevance to public health. Nutrients, 14(20, article no. 4408), 1-14.
DOI Scopus32 WoS29 Europe PMC32 |
| 2022 |
Pham, K., Mulugeta, A., Zhou, A., O'Brien, J. T., Llewellyn, D. J., & Hyppönen, E. (2022). High coffee consumption, brain volume and risk of dementia and stroke.. Nutritional Neuroscience, 25(10), 2111-2122.
DOI Scopus27 WoS29 Europe PMC25 |
| 2022 |
Neumann, A., Nolte, I. M., Pappa, I., Ahluwalia, T. S., Pettersson, E., Rodriguez, A., . . . Tiemeier, H. (2022). A genome-wide association study of total child psychiatric problems scores. Plos One, 17(8 August), 23 pages.
DOI Scopus19 WoS16 Europe PMC25 |
| 2022 |
Jami, E. S., Hammerschlag, A. R., Ip, H. F., Allegrini, A. G., Benyamin, B., Border, R., . . . Middeldorp, C. M. (2022). Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms. Journal of the American Academy of Child and Adolescent Psychiatry, 61(7), 934-945.
DOI Scopus43 WoS38 Europe PMC54 |
| 2022 |
Dickson, C., Zhou, A., MacIntyre, E., & Hyppönen, E. (2022). Do chronic low back pain and chronic widespread pain differ in their association with depression symptoms in the 1958 British Cohort?. Pain Med, 24(6), 23 pages.
DOI Scopus7 WoS8 Europe PMC7 |
| 2021 |
Sutherland, J. P., Zhou, A., Leach, M. J., & Hypponen, E. (2021). Differences and determinants of vitamin D deficiency among UK biobank participants: a cross-ethnic and socioeconomic study. Clinical Nutrition, 40(5), 3436-3447.
DOI Scopus44 WoS42 Europe PMC41 |
| 2021 |
Madakkatel, I., Zhou, A., McDonnell, M. D., & Hyppönen, E. (2021). Combining machine learning and conventional statistical approaches for risk factor discovery in a large cohort study. Scientific Reports, 11(1, article no. 22997), 11 pages.
DOI Scopus49 WoS46 Europe PMC40 |
| 2021 |
Zhou, A., & Hyppönen, E. (2021). Habitual coffee intake and plasma lipid profile: evidence from UK Biobank. Clinical Nutrition, 40(6), 4404-4413.
DOI Scopus26 WoS23 Europe PMC20 |
| 2021 |
Hyppönen, E., & Zhou, A. (2021). Cardiovascular symptoms affect the patterns of habitual coffee consumption. American Journal of Clinical Nutrition, 114(1), 214-219.
DOI Scopus14 WoS14 Europe PMC9 |
| 2021 |
Bejar, C. A., Goyal, S., Afzal, S., Mangino, M., Zhou, A., Hyppönen, E., & Sanghera, D. K. (2021). A Bidirectional Mendelian Randomization Study to evaluate the causal role of reduced blood vitamin D levels with type 2 diabetes risk in South Asians and Europeans. Nutrition Journal, 20(1), 1-11.
DOI Scopus15 WoS15 Europe PMC14 |
| 2021 |
Najjar, L., Sutherland, J., Zhou, A., & Hyppönen, E. (2021). Vitamin D and type 1 diabetes risk: a systematic review and meta-analysis of genetic evidence. Nutrients, 13(12, article no. 4260), 1-15.
DOI Scopus14 WoS14 Europe PMC12 |
| 2021 |
Vimaleswaran, K. S., Zhou, A., Cavadino, A., & Hyppönen, E. (2021). Evidence for a causal association between milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals. International Journal of Obesity, 45(8), 1751-1762.
DOI Scopus23 WoS23 Europe PMC19 |
| 2021 |
Zhou, A., Selvanayagam, J. B., & Hyppönen, E. (2021). Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk. European heart journal, 43(18), 1731-1739.
DOI Scopus156 WoS150 Europe PMC128 |
| 2020 |
Mulugeta, A., Zhou, A., King, C., & Hyppönen, E. (2020). Association between major depressive disorder and multiple disease outcomes: a phenome-wide Mendelian randomisation study in the UK Biobank. Molecular psychiatry, 25(7), 1469-1476.
DOI Scopus71 WoS73 Europe PMC79 |
| 2020 |
Stasinopoulos, L. C., Zhou, A., & Hypponen, E. (2020). Association of supplemental calcium and dairy milk intake with all-cause and cause-specific mortality in the UK Biobank: a prospective cohort study. British Journal of Nutrition, 123(5), 574-582.
DOI Scopus9 WoS8 Europe PMC9 |
| 2020 |
Nicolopoulos, K., Mulugeta, A., Zhou, A., & Hypponen, E. (2020). Association between habitual coffee consumption and multiple disease outcomes: a Mendelian randomisation phenome-wide association study in the UK Biobank. Clinical Nutrition, 39(11), 3467-3476.
DOI Scopus37 WoS35 Europe PMC33 |
| 2020 |
King, C., Mulugeta, A., Nabi, F., Walton, R., Zhou, A., & Hyppönen, E. (2020). Mendelian randomization case-control PheWAS in UK Biobank shows evidence of causality for smoking intensity in 28 distinct clinical conditions. EClinicalMedicine, 26(100488), 1-7.
DOI Scopus20 WoS20 Europe PMC20 |
| 2020 |
Lumsden, A. L., Mulugeta, A., Zhou, A., & Hyppönen, E. (2020). Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank. EBioMedicine, 59(102954), 1-11.
DOI Scopus209 WoS202 Europe PMC211 |
| 2020 |
Zheng, Y., Huang, T., Wang, T., Mei, Z., Zhou, A., Hypponen, E., & Qi, L. (2020). Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood. European Journal of Epidemiology, 35(7), 685-697.
DOI Scopus11 WoS11 Europe PMC9 |
| 2019 |
Mulugeta, A., Zhou, A., Vimaleswaran, K. S., Dickson, C., & Hyppönen, E. (2019). Depression increases the genetic susceptibility to high body mass index: Evidence from UK Biobank. Depression and Anxiety, 36(12), 1154-1162.
DOI Scopus37 WoS35 Europe PMC34 |
| 2019 |
Tyrrell, J., Mulugeta, A., Wood, A. R., Zhou, A., Beaumont, R. N., Tuke, M. A., . . . Hyppӧnen, E. (2019). Using genetics to understand the causal influence of higher BMI on depression. International journal of epidemiology, 48(3), 834-848.
DOI Scopus173 WoS157 Europe PMC148 |
| 2019 |
Skaaby, T., Kilpeläinen, T. O., Taylor, A. E., Mahendran, Y., Zhou, A., Hyppönen, E., & Linneberg, A. (2019). Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis. Addiction, 114(2), 216-225.
DOI Scopus25 WoS21 Europe PMC20 |
| 2019 |
Zhou, A., Morris, H. A., & Hyppönen, E. (2019). Health effects associated with serum calcium concentrations: evidence from MR-PheWAS analysis in UK Biobank. Osteoporosis International, 30(11), 2343-2348.
DOI Scopus21 WoS21 Europe PMC18 |
| 2019 |
Huang, T., Wang, T., Zheng, Y., Ellervik, C., Zhou, A., Hyppönen, E., & Qi, L. (2019). Association of birth weight with type 2 diabetes and glycemic traits: a mendelian randomization study. JAMA network open, 2(9, article no. e1910915), 1-18.
DOI Scopus47 WoS45 Europe PMC44 |
| 2019 |
Zhou, A., & Hyppönen, E. (2019). Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases. The American journal of clinical nutrition, 109(3), 509-516.
DOI Scopus88 WoS79 Europe PMC66 |
| 2019 |
Hypponen, E., Mulugeta, A., Zhou, A., & Santhanakrishnan, V. K. (2019). A data-driven approach for studying the role of body mass in multiple diseases: a phenome-wide registry-based case-control study in the UK Biobank. The Lancet digital health, 1(3), e116-e126.
DOI Scopus57 WoS56 Europe PMC67 |
| 2019 |
Gill, D., Benyamin, B., Moore, L. S. P., Monori, G., Zhou, A., Koskeridis, F., . . . Tzoulaki, I. (2019). Associations of genetically determined iron status across the phenome: a mendelian randomization study. PLOS medicine, 16(6, article no. e1002833), 1-16.
DOI Scopus51 WoS47 Europe PMC52 |
| 2019 |
Folley, S., Zhou, A., Llewellyn, D. J., & Hyppenen, E. (2019). Physical activity, APOE genotype, and cognitive decline: exploring gene-environment interactions in the UK Biobank. Journal of Alzheimers disease, 71(3), 741-750.
DOI Scopus18 WoS19 Europe PMC17 |
| 2019 |
Zhou, A., & Hypponen, E. (2019). Reply to PA Atroszko. The American journal of clinical nutrition, 110(5), 1259-1260.
DOI |
| 2018 |
Zhou, A., & Hyppönen, E. (2018). The Alleged Health-Protective Effects of Coffee. JAMA Internal Medicine, 178(12), 1725.
DOI WoS1 |
| 2018 |
Kuźma, E., Hannon, E., Zhou, A., Lourida, I., Bethel, A., Levine, D. A., . . . Llewellyn, D. J. (2018). Which risk factors causally influence Dementia? A systematic review of Mendelian randomization studies. Journal of Alzheimer's disease, 64(1), 181-193.
DOI Scopus43 WoS43 Europe PMC37 |
| 2018 |
Folley, S., Zhou, A., & Hypponen, E. (2018). Information bias in measures of self-reported physical activity. International journal of obesity, 42(12), 2062-2063.
DOI Scopus18 WoS18 Europe PMC19 |
| 2018 |
Mulugeta, A., Zhou, A., Power, C., & Hyppönen, E. (2018). Obesity and depressive symptoms in mid-life: a population-based cohort study. BMC Psychiatry, 18(297), 1-10.
DOI Scopus55 WoS53 Europe PMC47 |
| 2018 |
Jiang, X., O'Reilly, P. F., Aschard, H., Hsu, Y. H., Zhou, A., Hypponen, E., & Kiel, D. P. (2018). Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nature communications, 9(1, article no. 260), 1-12.
DOI Scopus335 WoS326 Europe PMC305 |
| 2018 |
Zhou, A., Taylor, A. E., Karhunen, V., Zhan, Y., & Hypponen, E. (2018). Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants. Scientific reports, 8(7526), 1-9.
DOI Scopus46 WoS44 Europe PMC36 |
| 2017 |
Dale, C., Fatemifar, G., Palmer, T., White, J., Prieto-Merino, D., Zabaneh, D., . . . Casas, J. (2017). Causal associations of adiposity and body fat distribution with coronary heart disease, stroke subtypes, and type 2 diabetes mellitus: a Mendelian randomization analysis. Circulation, 135(24), 2373-2388.
DOI Scopus298 WoS285 Europe PMC279 |
| 2017 |
Skaaby, T., Taylor, A. E., Jacobsen, R. K., Paternoster, L., Zhou, A., Hyppönen, E., & Linneberg, A. (2017). Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium. Scientific reports, 7(2224), 1-9.
DOI Scopus42 WoS39 Europe PMC33 |
| 2017 |
Maddock, J., Zhou, A., Cavadino, A., Kuźma, E., & Hyppönen, E. (2017). Vitamin D and cognitive function: A Mendelian randomisation study. Scientific Reports, 7(1, article no. 13230), 1-8.
DOI Scopus56 WoS49 Europe PMC39 |
| 2014 |
Roberts, C. T., Leemaqz, S. Y., Bianco Miotto, T., Andraweera, P. H., Zhou, A., McCowan, L. M., & Dekker, G. A. (2014). How big is big enough? Population differences in pregnancy outcome. Placenta, 35(9), 2.
DOI |
| 2014 |
Sykes, S., Pringle, K., Zhou, A., Dekker, G., Roberts, C., & Lumbers, E. (2014). The balance between human maternal plasma angiotensin II and angiotensin 1-7 levels in early gestation pregnancy is influenced by fetal sex. Journal of Renin-Angiotensin-Aldosterone System, 15(4), 523-531.
DOI Scopus16 WoS14 Europe PMC15 |
| 2014 |
Sykes, S., Pringle, K., Zhou, A., Dekker, G., Roberts, C., & Lumbers, E. (2014). Fetal sex and the circulating renin-angiotensin system during early gestation in women who later develop preeclampsia or gestational hypertension. Journal of Human Hypertension, 28(2), 133-139.
DOI Scopus37 WoS26 Europe PMC34 |
| 2013 |
Zhou, A., Dekker, G., Lumbers, E., Leemaqz, S., Thompson, S., McCowan, L., & Roberts, C. (2013). The association of AGTR2 polymorphisms with preeclampsia and uterine artery bilateral notching is modulated by maternal BMI. Placenta, 34(1), 75-81.
DOI Scopus28 WoS27 Europe PMC25 |
| 2013 |
Zhou, A., Dekker, G., Lumbers, E., Leemaqz, S., Thompson, S., Heinemann, G., . . . Roberts, C. (2013). The association of maternal ACE A11860G with small for gestational age babies is modulated by the environment and by fetal sex: a multicentre prospective case–control study. Molecular Human Reproduction, 19(9), 618-627.
DOI Scopus11 WoS9 Europe PMC10 |
