Dr Andrew Barrow

ARC Grant-Funded Researcher (A)

School of Agriculture, Food and Wine

College of Science

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.


Dr Andrew Barrow is a postdoctoral researcher in the Soares da Costa laboratory and his research is mainly focused on the design and synthesis of novel small molecules for use as herbicidal scaffolds.Dr Barrow obtained his PhD in Chemistry from the University of Nottingham, under the supervision of Professor John Moses, where his research centred around the development of photoactive chemical probes for protein footprinting, a technique designed to elucidate information about protein-protein interactions. He relocated with the Moses group to La Trobe University, Melbourne to undertake postdoctoral research in the emerging field of SuFEx click chemistry, particularly in the synthesis of heterocycles decorated with click handles.Following his time at La Trobe University, Dr Barrow held a short-term research position in the group of Professor David Procter at the University of Manchester, exploring asymmetric catalysis before returning to Australia to join the Soares da Costa laboratory at the University of Adelaide.

Date Position Institution name
2022 - ongoing Grant Funded Researcher University of Adelaide
2021 - 2021 Research Associate University of Manchester
2017 - 2021 Research Officer La Trobe University

Date Institution name Country Title
2012 - 2016 University of Nottingham United Kingdom PhD
2008 - 2012 University of Bath United Kingdom MChem

Year Citation
2025 Mackie, E. R. R., Mckay, M. V., Barrow, A. S., & da Costa, T. P. S. (2025). Inhibitors of lysine biosynthesis enzymes as potential new herbicides. Functional Plant Biology, 52(5), FP25030-1-FP25030-13.
DOI
2024 Homer, J. A., Koelln, R. A., Barrow, A. S., Gialelis, T. L., Boiarska, Z., Steinohrt, N. S., . . . Moses, J. E. (2024). Modular synthesis of functional libraries by accelerated SuFEx click chemistry. Chemical Science, 15(11), 3879-3892.
DOI Scopus13 WoS13 Europe PMC4
2023 Mackie, E. R. R., Barrow, A. S., Giel, M. -C., Hulett, M. D., Gendall, A. R., Panjikar, S., & Soares da Costa, T. P. (2023). Repurposed inhibitor of bacterial dihydrodipicolinate reductase exhibits effective herbicidal activity. Communications Biology, 6(1), 1-11.
DOI Scopus3 WoS3 Europe PMC4
2022 Smedley, C. J., Homer, J. A., Gialelis, T. L., Barrow, A. S., Koelln, R. A., & Moses, J. E. (2022). Accelerated SuFEx Click Chemistry For Modular Synthesis**. Angewandte Chemie - International Edition, 61(4), 8 pages.
DOI Scopus98 WoS101 Europe PMC58
2022 Mackie, E. R. R., Barrow, A. S., Christoff, R. M., Abbott, B. M., Gendall, A. R., & Soares da Costa, T. P. (2022). A dual-target herbicidal inhibitor of lysine biosynthesis. eLife, 11, 1-11.
DOI Scopus8 WoS7 Europe PMC6
2022 Wyllie, J. A., McKay, M. V., Barrow, A. S., & Soares da Costa, T. P. (2022). Biosynthesis of uridine diphosphate N-Acetylglucosamine: An underexploited pathway in the search for novel antibiotics?. IUBMB life, 71(12), 1232-1252.
DOI Scopus13 WoS11 Europe PMC12
2021 Giel, M. C., Barrow, A. S., Smedley, C. J., Lewis, W., & Moses, J. E. (2021). Aminium cation-radical catalysed selective hydration of (E)-aryl enynes. Chemical Communications, 57(57), 6991-6994.
DOI Scopus6 WoS5 Europe PMC4
2020 Smedley, C. J., Li, G., Barrow, A. S., Gialelis, T. L., Giel, M. C., Ottonello, A., . . . Moses, J. E. (2020). Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs. Angewandte Chemie - International Edition, 59(30), 12460-12469.
DOI Scopus110 WoS111 Europe PMC59
2019 Barrow, A. S., Smedley, C. J., Zheng, Q., Li, S., Dong, J., & Moses, J. E. (2019). The growing applications of SuFEx click chemistry. Chemical Society Reviews, 48(17), 4731-4758.
DOI Scopus456 WoS449 Europe PMC276
2018 Randall, J. D., Eyckens, D. J., Stojcevski, F., Francis, P. S., Doeven, E. H., Barlow, A. J., . . . Henderson, L. C. (2018). Modification of Carbon Fibre Surfaces by Sulfur-Fluoride Exchange Click Chemistry. ChemPhysChem, 19(23), 3176-3181.
DOI Scopus43 WoS42 Europe PMC16
2018 Smedley, C. J., Stanley, P. A., Qazzaz, M. E., Prota, A. E., Olieric, N., Collins, H., . . . Moses, J. E. (2018). Sustainable Syntheses of (-)-Jerantinines A & e and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site. Scientific Reports, 8(1), 7 pages.
DOI Scopus11 WoS13 Europe PMC10
2018 Smedley, C. J., Giel, M. C., Molino, A., Barrow, A. S., Wilson, D. J. D., & Moses, J. E. (2018). 1-Bromoethene-1-sulfonyl fluoride (BESF) is another good connective hub for SuFEx click chemistry. Chemical Communications, 54(47), 6020-6023.
DOI Scopus79 WoS79 Europe PMC37
2018 Jenner, M., Kosol, S., Griffiths, D., Prasongpholchai, P., Manzi, L., Barrow, A. S., . . . Challis, G. L. (2018). Mechanism of intersubunit ketosynthase-dehydratase interaction in polyketide synthases. Nature Chemical Biology, 14(3), 270-275.
DOI Scopus28 WoS30 Europe PMC31
2017 Manzi, L., Barrow, A. S., Hopper, J. T. S., Kaminska, R., Kleanthous, C., Robinson, C. V., . . . Oldham, N. J. (2017). Carbene Footprinting Reveals Binding Interfaces of a Multimeric Membrane-Spanning Protein. Angewandte Chemie - International Edition, 56(47), 14873-14877.
DOI Scopus34 WoS33 Europe PMC30
2017 Smedley, C. J., Barrow, A. S., Spiteri, C., Giel, M. C., Sharma, P., & Moses, J. E. (2017). Sulfur–Fluoride Exchange (SuFEx)-Mediated Synthesis of Sterically Hindered and Electron-Deficient Secondary and Tertiary Amides via Acyl Fluoride Intermediates. Chemistry - A European Journal, 23(42), 9990-9995.
DOI Scopus45 WoS44 Europe PMC22
2016 Stanley, P. A., Spiteri, C., Moore, J. C., Barrow, A. S., Sharma, P., & Moses, J. E. (2016). Biomimetic approaches towards the synthesis of complex dimeric natural products. Current Pharmaceutical Design, 22(12), 1628-1657.
DOI Scopus10 WoS10 Europe PMC5
2016 Barrow, A. S., & Moses, J. E. (2016). Synthesis of Sulfonyl Azides via Lewis Base Activation of Sulfonyl Fluorides and Trimethylsilyl Azide. Synlett, 27(12), 1840-1843.
DOI Scopus34 WoS32
2016 Manzi, L., Barrow, A. S., Scott, D., Layfield, R., Wright, T. G., Moses, J. E., & Oldham, N. J. (2016). Carbene footprinting accurately maps binding sites in protein-ligand and protein-protein interactions. Nature Communications, 7(1), 9 pages.
DOI Scopus61 WoS64 Europe PMC58

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Co-Supervisor Structural and functional characterisation of protein targets to guide the design of novel herbicides Master of Philosophy Master Full Time Chaudhry Artemiy Hussnain
2025 Co-Supervisor Structural and functional characterisation of protein targets to guide the design of novel herbicides Master of Philosophy Master Full Time Chaudhry Artemiy Hussnain

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