| 2026 |
Pham, K., Mulugeta, A., Lumsden, A., & Hyppӧnen, E. (2026). A multivariable Mendelian randomization study of serum lipids and dementia risk within the UK Biobank. Journal of Nutritional Biochemistry, 148(110160), 1-9.
DOI |
| 2025 |
Mulugeta, A., Stacey, D., Lumsden, A. L., Madakkatel, I., Lee, S. H., Mäenpää, J., . . . Hyppönen, E. (2025). Protein markers of ovarian cancer and its subtypes: insights from proteome-wide Mendelian randomisation analysis. British Journal Of Cancer, 133(8), 1208-1217.
DOI |
| 2025 |
Yeshaw, Y., Madakkatel, I., Mulugeta, A., Lumsden, A., & Hypponen, E. (2025). Machine learning to discover factors predicting volume of white matter hyperintensities: insights from the UK Biobank. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 17(1, article no. e70090), 1-12.
DOI |
| 2025 |
Lumsden, A. L., Mulugeta, A., & Hypponen, E. (2025). Dementia risk across distinct metabolic profiles in the UK Biobank. Geroscience, online, 1-25.
DOI |
| 2024 |
Yeshaw, Y., Madakkatel, I., Mulugeta, A., Lumsden, A., & Hyppönen, E. (2024). Uncovering predictors of low hippocampal volume: evidence from a large-scale machine-learning-based study in the UK biobank. Neuroepidemiology, 58(5), 369-382.
DOI |
| 2024 |
Mulugeta, A., Lumsden, A., Madakkatel, I., Stacey, D., Lee, S. H., Mäenpää, J., . . . Hypponen, E. (2024). Phenome-wide association study of ovarian cancer identifies common comorbidities and reveals shared genetics with complex diseases and biomarkers. Cancer Medicine, 13(4, article no. e7051), 1-13.
DOI Scopus2 Europe PMC3 |
| 2024 |
Madakkatel, I., Lumsden, A. L., Mulugeta, A., Mäenpää, J., Oehler, M. K., & Hyppönen, E. (2024). Large-scale analysis to identify risk factors for ovarian cancer. International Journal of Gynecological Cancer, 35(8, article no. 101844), 005424-1-005424-9.
DOI Scopus6 WoS6 Europe PMC5 |
| 2024 |
Yalew, M., Mulugeta, A., Lumsden, A. L., Madakkatel, I., Lee, S. H., Oehler, M. K., . . . Hyppönen, E. (2024). Circulating Phylloquinone and the Risk of Four Female-Specific Cancers: A Mendelian Randomization Study. Nutrients, 16(21), nu16213680-1-nu16213680-9.
DOI |
| 2023 |
Pham, K., Mulugeta, A., Lumsden, A., & Hyppӧnen, E. (2023). Genetically instrumented LDL-cholesterol lowering and multiple disease outcomes: A Mendelian randomization phenome-wide association study in the UK Biobank. British Journal of Clinical Pharmacology, 89(10), 2992-3004.
DOI Scopus5 WoS4 Europe PMC4 |
| 2023 |
Ahmed, M., Mäkinen, V. -P., Lumsden, A., Boyle, T., Mulugeta, A., Lee, S. H., . . . Hyppönen, E. (2023). Metabolic profile predicts incident cancer: A large-scale population study in the UK Biobank.. Metabolism: clinical and experimental, 138(155342), 1-9.
DOI Scopus8 WoS8 Europe PMC4 |
| 2023 |
Madakkatel, I., Lumsden, A. L., Mulugeta, A., Olver, I., & Hyppönen, E. (2023). Hypothesis-free discovery of novel cancer predictors using machine learning. European Journal of Clinical Investigation, 53(10), 1-13.
DOI Scopus4 WoS4 Europe PMC4 |
| 2023 |
Lumsden, A. L., Mulugeta, A., Makinen, V. P., & Hypponen, E. (2023). Metabolic profile-based subgroups can identify differences in brain volumes and brain iron deposition. Diabetes Obesity & Metabolism, 25(1), 121-131.
DOI |
| 2023 |
Jones, L. A., Sun, E. W., Lumsden, A. L., Thorpe, D. W., Peterson, R. A., De Fontgalland, D., . . . Keating, D. J. (2023). Alterations in GLP-1 and PYY release with aging and body mass in the human gut. Molecular and Cellular Endocrinology, 578(112072), 1-6.
DOI |
| 2022 |
Mulugeta, A., Navale, S. S., Lumsden, A. L., Llewellyn, D. J., & Hyppönen, E. (2022). Healthy lifestyle, genetic risk and brain health: a gene-environment interaction study in the UK Biobank. Nutrients, 14(19, article no. 3907), 1-13.
DOI |
| 2022 |
Ashander, L. M., Lumsden, A. L., Dawson, A. C., Ma, Y., Ferreira, L. B., Oliver, G. F., . . . Smith, J. R. (2022). Infection of human retinal pigment epithelial cells with dengue virus strains isolated during outbreaks in Singapore. Microorganisms, 10(2, article no. 310), 1-14.
DOI WoS9 |
| 2022 |
Lumsden, A. L., Mulugeta, A., & Hyppönen, E. (2022). Milk consumption and risk of twelve cancers: a large-scale observational and Mendelian randomisation study. Clinical Nutrition, 42(1), 1-8.
DOI |
| 2022 |
Mulugeta, A., Eshetie, T. C., Kassie, G. M., Erku, D., Mekonnen, A., Lumsden, A., & Hypponen, E. (2022). Association between metabolically different adiposity subtypes and osteoarthritis: a Mendelian Randomization Study. Arthritis Care & Research, 75(4), 885-892.
DOI |
| 2022 |
Castro, J., Garcia-Caraballo, S., Maddern, J., Schober, G., Lumsden, A., Harrington, A., . . . Brierley, S. M. (2022). Olorinab (APD371), a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2, reduces colitis-induced acute and chronic visceral hypersensitivity in rodents. Pain, 163(1), e72-e86.
DOI Scopus24 WoS24 Europe PMC20 |
| 2021 |
Sun, E. W., Iepsen, E. W., Pezos, N., Lumsden, A. L., Martin, A. M., Schober, G., . . . Keating, D. J. (2021). A gut-intrinsic melanocortin signalling complex augments L cell secretion in humans. Gastroenterology, 161(2), 536-547.
DOI Scopus13 WoS14 Europe PMC11 |
| 2021 |
Mulugeta, A., Lumsden, A., & Hyppönen, E. (2021). Relationship between serum 25(Oh)d and depression: causal evidence from a bi-directional mendelian randomization study. Nutrients, 13(1), 1-13.
DOI |
| 2021 |
Mulugeta, A., Lumsden, A., & Hyppönen, E. (2021). Unlocking the causal link of metabolically different adiposity subtypes with brain volumes and the risks of dementia and stroke: a Mendelian randomization study. Neurobiology of Aging, 102, 161-169.
DOI |
| 2020 |
Lumsden, A. L., Mulugeta, A., Zhou, A., & Hyppönen, E. (2020). Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank. EBioMedicine, 59(102954), 1-11.
DOI Scopus202 Europe PMC207 |
| 2020 |
Hin, N., Newman, M., Kaslin, J., Douek, A. M., Lumsden, A., Moussavi Nik, S. H., . . . Lardelli, M. (2020). Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2. PloS one, 15(1), e0227258.
DOI Scopus27 WoS24 Europe PMC30 |
| 2020 |
Grundy, L., Caldwell, A., Lumsden, A., Mohammadi, E., Hannig, G., Greenwood Van-Meervald, B., & Brierley, S. M. (2020). Experimentally induced bladder permeability evokes bladder afferent hypersensitivity in the absence of inflammation. Frontiers in Neuroscience, 14(590871), 1-10.
DOI Scopus15 WoS13 Europe PMC13 |
| 2019 |
Lumsden, A. L., Martin, A. M., Sun, E. W., Schober, G., Isaacs, N. J., Pezos, N., . . . Keating, D. J. (2019). Sugar responses of human enterochromaffin cells depend on gut region, sex, and body mass. Nutrients, 11(2), 1-13.
DOI Scopus23 WoS22 Europe PMC23 |
| 2019 |
Castro, J., Harrington, A. M., Lieu, T., Garcia Caraballo, S., Maddern, J., Schober, G., . . . Brierley, S. M. (2019). Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity. JCI insight, 4(20), e131712-1-e131712-24.
DOI Scopus62 WoS62 Europe PMC54 |
| 2018 |
Young, R., Lumsden, A., Martin, A., Schober, G., Pezos, N., Thazhath, S., . . . Keating, D. (2018). Augmented capacity for peripheral serotonin release in human obesity. International Journal of Obesity, 42(11), 1880-1889.
DOI Scopus76 WoS67 Europe PMC55 |
| 2018 |
Lumsden, A., Rogers, J., Majd, S., Newman, M., Sutherland, G., Verdile, G., & Lardelli, M. (2018). Dysregulation of neuronal iron homeostasis as an alternative unifying effect of mutations causing familial Alzheimer's disease. Frontiers in Neuroscience, 12(533), 533-1-533-21.
DOI Scopus39 WoS37 Europe PMC35 |
| 2018 |
Lumsden, A. L., Ma, Y., Ashander, L. M., Stempel, A. J., Keating, D. J., Smith, J. R., & Appukuttan, B. (2018). ICAM-1-related long non-coding RNA: promoter analysis and expression in human retinal endothelial cells. BMC Research Notes, 11(285), 1-8.
DOI Europe PMC4 |
| 2017 |
Martin, A., Lumsden, A., Young, R., Jessup, C., Spencer, N., & Keating, D. (2017). The nutrient-sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon. Neurogastroenterology and Motility, 29(6), e13046-1-e13046-8.
DOI Scopus61 WoS53 Europe PMC48 |
| 2017 |
Martin, A., Lumsden, A., Young, R., Jessup, C., Spencer, N., & Keating, D. (2017). Regional differences in nutrient-induced secretion of gut serotonin. Physiological Reports, 5(6), 1-12.
DOI Scopus75 WoS68 Europe PMC64 |
| 2016 |
Mackenzie, K. D., Lumsden, A. L., Guo, F., Duffield, M. D., Chataway, T., Lim, Y., . . . Keating, D. J. (2016). Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Journal of Neurochemistry, 138(5), 710-721.
DOI Scopus22 WoS22 Europe PMC21 |
| 2016 |
Raghupathi, R., Jessup, C., Lumsden, A., & Keating, D. (2016). Fusion pore size limits 5-HT release from single enterochromaffin cell vesicles. Journal of Cellular Physiology, 231(7), 1593-1600.
DOI Scopus20 WoS19 Europe PMC16 |
| 2016 |
Lumsden, A., Young, R., Pezos, N., & Keating, D. (2016). Huntingtin-associated protein 1: eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine. BMC Evolutionary Biology, 16(1), 214-1-214-18.
DOI Scopus8 WoS9 Europe PMC6 |
| 2015 |
Zelkas, L., Raghupathi, R., Lumsden, A., Martin, A., Sun, E., Spencer, N., . . . Keating, D. (2015). Serotonin-secreting enteroendocrine cells respond via diverse mechanisms to acute and chronic changes in glucose availability. Nutrition and Metabolism, 12(1), 55.
DOI Scopus46 WoS39 Europe PMC38 |
| 2015 |
Young, R. L., Lumsden, A. L., & Keating, D. J. (2015). Gut serotonin is a regulator of obesity and metabolism. Gastroenterology, 149(1), 253-255.
DOI Scopus40 Europe PMC34 |
| 2011 |
Myre, M. A., Lumsden, A. L., Thompson, M. N., Wasco, W., MacDonald, M. E., & Gusella, J. F. (2011). Deficiency of huntingtin has pleiotropic effects in the social amoeba dictyostelium discoideum. PLoS Genetics, 7(4), 1-17.
DOI |
| 2009 |
Henshall, T., Tucker, B., Lumsden, A., Nornes, S., Lardelli, M., & Richards, R. (2009). Selective neuronal requirement for Huntingtin in the developing zebrafish. Human Molecular Genetics, 18(24), 4830-4842.
DOI Scopus43 WoS39 Europe PMC37 |
| 2007 |
Lumsden, A., Henshall, T., Dayan, S., Lardelli, M., & Richards, R. (2007). Huntingtin-deficient zebrafish exhibit defects in iron utilization and development. Human Molecular Genetics, 16(16), 1905-1920.
DOI Scopus138 WoS127 Europe PMC109 |
| 2005 |
Miksch, S., Lumsden, A., Guenther, U., Foernzler, D., Christen-Zach, S., Daugherty, C., . . . Struk, B. (2005). Molecular genetics of pseudoxanthoma elasticum: Type and frequency of mutations in ABCC6. Human Mutation, 26(3), 235-248.
DOI Scopus98 WoS81 Europe PMC79 |
| 2001 |
Cai, L., Lumsden, A., Guenther, U., Nelder, S., Zach, S., Knoblauch, H., . . . Struk, B. (2001). A novel Q378X mutation exists in the transmembrane transporter protein ABCC6 and its pseudogene: implications for mutation analysis in pseudoxanthoma elasticum. Journal of Molecular Medicine-JMM, 79(9), 536-546.
DOI Scopus45 WoS42 Europe PMC35 |
| 2000 |
Struk, B., Cai, L., Zäch, S., Ji, W., Chung, J., Lumsden, A., . . . Lindpaintner, K. (2000). Mutations of the gene encoding the transmembrane transporter protein ABC-C6 cause pseudoxanthoma elasticum. Journal of Molecular Medicine, 78(5), 282-286.
DOI Scopus123 Europe PMC86 |
