Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
I am a post-doctoral research scientist in the Translational Research Unit, Genetics and Molecular Pathology (WCH campus), SA Pathology, Adelaide. My research interest focuses on finding a minimally invasive therapy to treat CNS and skeletal disease in a group of genetic diseases called MPS disorders. This involves combining work targeting inhibition of glycoaminoglycans and gangliosides (substrate deprivation therapy), using lentiviral gene therapy and understanding the mechanisms behind MPS disease pathology and how this is affected by treatment, with a particular focus on the bone and brain using in vitro systems and mouse models.
- My Research
- Grants and Funding
- Professional Activities
The overall aim of my research is to develop both in vitro and in vivo models for a group of genetic diseases called MPS. I am focusing on the 2 areas of MPS that are not adequately addressed using current therapies, the brain and skeleton. Having access to these improved tools will allow a better understanding of the pathogenesis of disease, identify key markers and pathways that lead to cell and organ dysfunction. Having a broader range of models will permit testing and implementation of therapeutic strategies necessary that have the potential for clinical translation.
Date Position Institution name 2008 Affiliate Lecturer University of Adelaide 2008 Grant Funded Post-Doctoral Scientist SA Pathology 2008 - 2007 Grant Funded Post-Doctoral Scientist Children, Youth and Women’s Health Service 2001 - 2002 2001-2002 Grant Funded Scientist Women’s and Children’s Hospital, Adelaide
Awards and Achievements
Date Type Title Institution Name Country Amount 2013 Award Runner-up, New Investigator Award MBSANZ Australia — 2012 Fellowship Malcolm Douglas Post-Doctoral Grant Women and Childrens Hospital Foundation Australia — 2012 Award Semi-finalist in Young Investigator Award — Australia — 2012 Award Finalist, New Investigator Award MBSANZ Australia —
Date Institution name Country Title 2003 - 2007 University of Adelaide Australia PhD, Department of Paediatrics 1998 - 2001 University of South Australia Australia Bachelor of Medical and Pharmaceutical Biotechnology (Honours)
Date Title Institution name Country 1997 South Australian Certificate of Education Walford Anglican School for Girls Austarlia
Year Citation 2017 Byers, S., Jiang, Z., Reichstein, C., & Derrick-Roberts, A. L. K. (2017). Cell cycle progression is disrupted in murine MPS VII growth plate chondrocytes. In MOLECULAR GENETICS AND METABOLISM Vol. 120 (pp. S33). San Diego, CA: ACADEMIC PRESS INC ELSEVIER SCIENCE.
2016 Jiang, Z., Rossouw, C., Reichstein, C., Macsai, C. E., Jackson, M. R., Derrick-Roberts, A. L. K., & Byers, S. (2016). Reduced chondrocyte proliferation and hypertrophy contribute to delayed endochondral bone formation in murine mucopolysaccharidosis VII. In MOLECULAR GENETICS AND METABOLISM Vol. 117 (pp. S62-S63). San Diego, CA: ACADEMIC PRESS INC ELSEVIER SCIENCE.
2015 Jackson, M., Robertsa, A., Gronthos, S., & Byers, S. (2015). α-l-Iduronidase transduced mesenchymal stem cells improve the behavioral deficits in mucopolysaccharidosis type I mice. In Abstracts Molecular Genetics and Metabolism Vol. 114 (pp. S58). Orlando, FL: Elsevier.
Year Citation 2018 Byers, S., Rout-Pitt, N., Linard, H., Vaidyanathan, S., & Derrick-Roberts, A. L. K. (2018). MESENCHYMAL STEM CELL DIFFERENTIATION IS MODULATED BY COMPLEX SUGARS IN MPS DISEASE. Poster session presented at the meeting of JOURNAL OF GENE MEDICINE. Univ Technol Sydney, Sydney, AUSTRALIA: WILEY.
|Date||Project Title.||Investigators||Funding Body||Amount|
A No Nonsense Approach To Sanfilippo Syndrome
|L Jolly, A Derrick-Roberts, K Hemsley, N Smith||Sanfilippo Children’s Foundation||90,000|
Can the cell cycle be re-set to normal in MPS growth plate chondrocytes?
|S Byers, A Derrick-Roberts, Z Jiang||The National MPS Society||US 90,000|
|2017||Understanding neurogenesis in MPS IIIA disease||A Derrick-Roberts, S Byers, L Jolly||University of Pennsylvannia, Penn Medicine Center for Orphan Disease Research and Therapies||US 52,000|
|2017||Generation of Pluripotent Stem Models for the study of Human Neurodevelopmental Disorders||L Jolly, J Hughes, A Derrick-Roberts||
Robinson Research Institute Innovation Seed Funding Program
|2017||In vivo growth hormone or IGF1 administration to improve bone length in a mouse model of MPS VII||S Byers, A Derrick-Roberts||Women’s and Children’s Hospital Research Foundation||75,000|
|2015 - 2016||Improved tools for studying MPS IVA||A Derrick-Roberts, S Byers||MPS Society||US 120,000|
|2015||Understanding how stem cell differentiation is affected in MPS I disease||S Byers, A Derrick-Roberts||Women’s and Children’s Hospital Research Foundation||74,815|
|2014 - 2015||Oral fatty acid supplementation as an adjunct therapy for MPS I||M Fuller, A Derrick-Roberts||US 330,000|
|2014 - 2015||Can linoleic acid improve cognitive function in a mouse model of an inherited metabolic disease of children||M Fuller, A Derrick-Roberts||Channel 7 Research Foundation||75,000|
|2013||Understanding the molecular mechanism of short stature in MPS||A Derrick-Roberts, S Byers||Women’s and Children’s Hospital Research Foundation||69,386|
|2012 - 2015||Targeting and understanding skeletal disease in MPS IVA||A Derrick-Roberts||Malcolm Douglas Grant Post-Doctoral Fellowship|
|2012||Can increasing enzyme delivery using gene therapy improve the outcome of brain disease in MPS IIIA?||A Derrick-Roberts, S Byers||Women’s and Children’s Hospital Research Foundation||49,708|
|2009||Substrate deprivation therapy for MPS I: the most common MPS type||A Derrick-Roberts, S Byers||Women’s and Children’s Hospital Research Foundation||48,532|
Laboratory Animal Science III, Lecturer, 2011-
Affiliate Lecturer, Adelaide Medical School, Faculty of Health Sciences 2008-
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2015 - 2019 Co-Supervisor The Neurogenic Potential of Stem Cells is Altered in Mucopolysaccharidosis Type IIIA Doctor of Philosophy Doctorate Full Time Rebecca Jayne Lehmann 2014 - 2018 Co-Supervisor Mechanisms of Growth Failure in Mucopolysaccharidosis VII Mice Doctor of Philosophy Doctorate Full Time Miss Zhirui Jiang
Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2018 - ongoing Principal Supervisor An in vitro model to study growth plate function. The University of Adelaide — Honours — Daniel Deverson 2017 - 2017 Principal Supervisor Does GH or iGF1 promote bone growth in MPS VII mice ? The University of Adelaide — Honours — Niemal Usmani
Date Role Committee Institution Country 2014 - ongoing Board Member Lions Medical Research Foundation Lions Clubs International Australia 2013 - 2014 Vice-President Matrix Biology Society for Australia and New Zealand — Australia 2009 - 2013 Secretary Matrix Biology Society for Australia and New Zealand — Australia 2007 - 2009 Representative Matrix Biology Society for Australia and New Zealand — Australia
Date Role Membership Country 2002 - ongoing Member Matrix Biology Society for Australia and New Zealand Australia
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