Patrick Hughes

• Appointments

  Date	Position	Institution name
  2014 - ongoing	Senior Lecturer	University of Adelaide

• Education

  Date	Institution name	Country	Title
  2004 - 2008	University of Adelaide	Adelaide	PhD
  1999 - 1999	University of Adelaide	Australia	B.Sc. (Hons).

• Research Interests

  Gastroenterology and Hepatology Immunology Neurosciences Nutrition and Metabolic Health Neuroscience, Behaviour and Brain Health Surgical and Health Systems Innovation Innovative Therapeutics

• Journals

  Year	Citation
  2021	Tam, S. Y., Coller, J. K., Hughes, P. A., Prestidge, C. A., & Bowen, J. M. (2021). Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation. Indian Journal of Gastroenterology, 40(1), 5-21. DOI Scopus48 WoS26 Europe PMC29
  2021	Ichinose, M., Suzuki, N., Wang, T., Wright, J. A., Lannagan, T. R. M., Vrbanac, L., . . . Woods, S. L. (2021). Delineating proinflammatory microenvironmental signals by ex vivo modeling of the immature intestinal stroma. Scientific Reports, 11(1), 7200-1-7200-11. DOI Scopus1 WoS1 Europe PMC1
  2020	Dmochowska, N., Tieu, W., Keller, M. D., Hollis, C. A., Campaniello, M. A., Mavrangelos, C., . . . Hughes, P. A. (2020). ⁸⁹Zr-pro-MMP-9 F(ab′)₂ detects colitis induced intestinal and kidney fibrosis. Scientific Reports, 10(1), 20372. DOI Scopus6 WoS2 Europe PMC5
  2019	Dmochowska, N., Tieu, W., Keller, M. D., Wardill, H. R., Mavrangelos, C., Campaniello, M. A., . . . Hughes, P. A. (2019). Immuno-PET of Innate Immune Markers CD11b and IL-1β Detects Inflammation in Murine Colitis. Journal of nuclear medicine : Official publication, Society of Nuclear Medicine, 60(6), 858-863. DOI Scopus28 WoS24 Europe PMC21
  2019	Costello, S. P., Hughes, P. A., Waters, O., Bryant, R. V., Vincent, A. D., Blatchford, P., . . . Andrews, J. M. (2019). Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis: a randomized clinical trial. JAMA - Journal of the American Medical Association, 321(2), 156-164. DOI Scopus592 WoS440 Europe PMC346
  2019	Wardill, H. R., Choo, J. M., Dmochowska, N., Mavrangelos, C., Campaniello, M. A., Bowen, J. M., . . . Hughes, P. A. (2019). Acute colitis drives tolerance by persistently altering the epithelial barrier and innate and adaptive immunity. Inflammatory Bowel Diseases, 25(7), 1196-1207. DOI Scopus11 WoS10 Europe PMC8
  2018	Dmochowska, N., Wardill, H., & Hughes, P. (2018). Advances in imaging specific mediators of inflammatory bowel disease. International Journal of Molecular Sciences, 19(9), 2471-1-2471-13. DOI Scopus34 WoS19 Europe PMC18
  2018	Dmochowska, N., Wardill, H., & Hughes, P. (2018). Advances in <em>In-Vivo</em> Imaging of Inflammatory Bowel Disease Mediators. DOI
  2018	Bashashati, M., Moossavi, S., Cremon, C., Barbaro, M., Moraveji, S., Talmon, G., . . . Barbara, G. (2018). Colonic immune cells in irritable bowel syndrome: a systematic review and meta-analysis. Neurogastroenterology and Motility, 30(1), e13192-1-e13192-13. DOI Scopus129 WoS95 Europe PMC64
  2018	Guerrero-Alba, R., Valdez-Morales, E. E., Jiménez-Vargas, N. N., Bron, R., Poole, D., Reed, D., . . . Vanner, S. (2018). Co-expression of μ and ∂ opioid receptors by mouse colonic nociceptors. British Journal of Pharmacology, 175(13), 2622-2634. DOI Scopus24 WoS18 Europe PMC17
  2018	Hofma, B., Wardill, H., Mavrangelos, C., Campaniello, M., Dimasi, D., Bowen, J., . . . Hughes, P. (2018). Colonic migrating motor complexes are inhibited in acute tri-nitro benzene sulphonic acid colitis. PLoS ONE, 13(6), e0199394-1-e0199394-15. DOI Scopus15 WoS13 Europe PMC11
  2018	Mavrangelos, C., Campaniello, M., Andrews, J., Bampton, P., & Hughes, P. (2018). Longitudinal analysis indicates symptom severity influences immune profile in irritable bowel syndrome. Gut, 67(2), 398-399. DOI Scopus7 WoS7 Europe PMC6
  2017	Mikocka-Walus, A., Bampton, P., Hetzel, D., Hughes, P., Esterman, A., & Andrews, J. (2017). Cognitive-behavioural therapy for inflammatory bowel disease: 24-month data from a randomised controlled trial. International Journal of Behavioral Medicine, 24(1), 127-135. DOI Scopus52 WoS41 Europe PMC39
  2017	Mikocka-Walus, A., Hughes, P. A., Bampton, P., Gordon, A., Campaniello, M. A., Mavrangelos, C., . . . Andrews, J. M. (2017). Fluoxetine for maintenance of remission and to improve quality of life in patients with Crohn's disease: a pilot randomised placebo-controlled trial. Journal of Crohn's & colitis, 11(4), 509-514. DOI Scopus44 WoS35 Europe PMC27
  2017	Campaniello, M. A., Mavrangelos, C., Eade, S., Harrington, A. M., Blackshaw, L. A., Brierley, S. M., . . . Hughes, P. A. (2017). Acute colitis chronically alters immune infiltration mechanisms and sensory neuro-immune interactions.. Brain, Behavior, and Immunity, 60, 319-332. DOI Scopus16 WoS15 Europe PMC11
  2016	Hughes, P., Costello, S., Bryant, R., & Andrews, J. (2016). Opioidergic effects on enteric and sensory nerves in the lower GI tract: basic mechanisms and clinical implications. American Journal of Physiology, 311(3), G501-G513. DOI Scopus21 WoS15 Europe PMC13
  2016	Campaniello, M., Harrington, A., Martin, C., Ashley Blackshaw, L., Brierley, S., & Hughes, P. (2016). Activation of colo-rectal high-threshold afferent nerves by Interleukin-2 is tetrodotoxin-sensitive and upregulated in a mouse model of chronic visceral hypersensitivity. Neurogastroenterology and Motility, 28(1), 54-63. DOI Scopus13 WoS13 Europe PMC12
  2016	Hughes, P. A. (2016). Sleeping in on pancreatic cancer pain: Schwann cell secreted IL-6 pushes snooze on the pain alarm. Gut, 65(6), 897-898. DOI Scopus2 WoS2
  2015	Mikocka-Walus, A., Bampton, P., Hetzel, D., Hughes, P., Esterman, A., & Andrews, J. (2015). Cognitive-behavioural therapy has no effect on disease activity but improves quality of life in subgroups of patients with inflammatory bowel disease: a pilot randomised controlled trial. BMC Gastroenterology, 15(1), 54-1-54-12. DOI Scopus63 WoS49 Europe PMC34
  2014	Hughes, P., Moretta, M., Lim, A., Grasby, D., Bird, D., Brierley, S., . . . Krumbiegel, D. (2014). Immune derived opioidergic inhibition of viscerosensory afferents is decreased in Irritable Bowel Syndrome patients. Brain, Behavior, and Immunity, 42, 191-203. DOI Scopus40 WoS37 Europe PMC29
  2014	Malsch, P., Andratsch, M., Vogl, C., Link, A. S., Alzheimer, C., Brierley, S. M., . . . Kress, M. (2014). Deletion of interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression. Journal of Neuroscience, 34(30), 9845-9856. DOI Scopus63 WoS55 Europe PMC42
  2013	Blackshaw, L., Brierley, S., Harrington, A., & Hughes, P. (2013). TRP channels in visceral pain. The Open Pain Journal, 6(SPEC.ISSUE.1), 23-30. DOI Scopus2
  2013	Hughes, P., Castro Kraftchenko, J., Harrington, A., Isaacs, N., Moretta, M., Hicks, G., . . . Brierley, S. (2013). Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity. Gut, Online(7), 1-2. DOI Scopus36 WoS34 Europe PMC26
  2013	Castro, J., Harrington, A., Hughes, P., Martin, C., Ge, P., Shea, C., . . . Brierley, S. (2013). Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-c and extracellular cyclic guanosine 3′,5′-monophosphate. Gastroenterology, 145(6), 1334-1346. DOI Scopus226 WoS192 Europe PMC156
  2013	Hughes, P., Harrington, A., Castro Kraftchenko, J., Liebregts, T., Adam, B., Grasby, D., . . . Brierley, S. (2013). Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes. Gut, 62(10), 1456-1465. DOI Scopus169 WoS148 Europe PMC118
  2013	Hughes, P., Zola, H., Penttila, I., Blackshaw, L., Andrews, J., & Krumbiegel, D. (2013). Immune activation in irritable bowel syndrome: can neuroimmune interactions explain symptoms?. American Journal of Gastroenterology, 108(7), 1066-1074. DOI Scopus127 WoS109 Europe PMC88
  2012	Harrington, A., Brierley, S., Isaacs, N., Hughes, P., Castro Kraftchenko, J., & Blackshaw, L. (2012). Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity. Journal of Comparative Neurology, 520(10), 2241-2255. DOI Scopus58 WoS53 Europe PMC32
  2012	Brierley, S., Castro, J., Harrington, A., Hughes, P., Martin, C., Silos-Santiago, A., . . . Blackshaw, A. (2012). Guanylate cyclase C receptor agonists, linaclotide and uroguanylin, modulate intestinal nociception. NEUROGASTROENTEROLOGY AND MOTILITY, 24, 26.
  2011	Harrington, A., Hughes, P., Martin, C., Yang, J., Castro, J., Isaacs, N., . . . Brierley, S. (2011). A novel role for TRPM8 in visceral afferent function. PAIN®, 152(7), 1459-1468. DOI Scopus122 WoS104 Europe PMC87
  2011	Blackshaw, L., Brierley, S., Hughes, P., & Harrington, A. (2011). The Hot Mustard Receptor's Role in Gut Motor Function. Gastroenterology, 141(2), 423-427. DOI Scopus9 WoS10 Europe PMC7
  2011	Brierley, S., Castro Kraftchenko, J., Harrington, A., Hughes, P., Page, A., Rychkov, G., & Blackshaw, L. (2011). TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. Journal of Physiology-London, 589(14), 3575-3593. DOI Scopus111 WoS99 Europe PMC76
  2011	Hughes, P. A., Brierley, S. M., & Martin, C. M. (2011). Post-inflammatory colonic afferent sensitisation: Different subtypes, different pathways and different time courses (Gut (2009) 58, (1333-1341)). Gut, 60(1), 140. DOI Scopus1 WoS1
  2010	Brierley, S., Hughes, P., Harrington, A., Rychkov, G., & Blackshaw, L. (2010). Identifying the ion channels responsible for signaling gastro-intestinal based pain. Pharmaceuticals, 3(9), 2768-2798. DOI Scopus14 WoS11 Europe PMC6
  2010	Blackshaw, L., Brierley, S., & Hughes, P. (2010). TRP channels: new targets for visceral pain. Gut, 59(1), 126-135. DOI Scopus70 WoS63 Europe PMC55
  2009	Brierley, S., Hughes, P., Page, A., Kwan, K., Martin, C., O'Donnell, T., . . . Blackshaw, L. (2009). The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology, 137(6), 2084-2095. DOI Scopus231 WoS206 Europe PMC165
  2009	Hughes, P., Brierley, S., & Blackshaw, L. (2009). Post-inflammatory modification of colonic afferent mechanosensitivity. Clinical and Experimental Pharmacology and Physiology, 36(10), 1034-1040. DOI Scopus58 WoS47 Europe PMC38
  2009	Hughes, P., Brierley, S., Martin, C., Brookes, S., Linden, D., & Blackshaw, L. (2009). Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses. Gut, 58(10), 1333-1341. DOI Scopus149 WoS131 Europe PMC118
  2009	Hughes, P., Brierley, S., Martin, C., Liebregts, T., Persson, J., Adam, B., . . . Blackshaw, L. (2009). TRPV1-expressing sensory fibres and IBS: links with immune function. Gut, 58(3), 465-466. DOI Scopus40 WoS34 Europe PMC11
  2008	Lindstrom, E., Brusberg, M., Hughes, P., Martin, C., Brierley, S., Phillis, B., . . . Blackshaw, L. (2008). Involvement of metabotropic glutamate 5 receptor in visceral pain. Pain, 137(2), 295-305. DOI Scopus60 WoS48 Europe PMC39
  2008	Brierley, S., Page, A., Hughes, P., Adam, B., Liebregts, T., Isaacs, N., . . . Blackshaw, L. (2008). Selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology, 134(7), 2059-2069. DOI Scopus223 WoS188 Europe PMC159
  2008	Lemmens, L., Urbach, S., Prudent, R., Cochet, C., Baldacci, G., & Hughes, P. (2008). Phosphorylation of the C subunit (p66) of human DNA polymerase δ. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 367(2), 264-270. DOI WoS11 Europe PMC8
  2007	Page, A., Brierley, S., Martin, C., Hughes, P., & Blackshaw, L. (2007). Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil. Pain, 133(1-3), 150-160. DOI Scopus58 WoS43 Europe PMC41
  2007	Hughes, P., Brierley, S., Young, R., & Blackshaw, L. (2007). Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia. Journal of Comparative Neurology, 500(5), 863-875. DOI Scopus83 WoS75 Europe PMC67
  2007	Hughes, P., Brierley, S., Page, A., Kwan, K., Corey, D., & Blackshaw, L. A. (2007). The ion channel TRPA1 is expressed in extrinsic colonic afferents and contributes to their mechanosensitivity. NEUROGASTROENTEROLOGY AND MOTILITY, 19, 19.
  2006	Callaghan, P., Farrand, K., Salem, A., Hughes, P., Daws, L., & Irvine, R. (2006). Repeated administration of the substituted amphetamine p-methoxyamphetamine produces reductions in cortical 5-HT transporter binding but not 5-HT content, unlike 3,4-methylenedioxyamethamphetamine. European Journal of Pharmacology, 546(1-3), 74-81. DOI Scopus7 WoS7 Europe PMC6
  2004	DeLaLande, I., Stepien, J., Philpott, A., Hughes, P., Stafford, I., & Horowitz, J. (2004). Aldehyde dehrdrogenase, nitric oxide synthase and superoxide in ex vivo nitrate tolerance in rat aorta. European Journal of Pharmacology, 496(1), 141-149. DOI Scopus17 WoS16 Europe PMC15

• Book Chapters

  Year	Citation
  2012	Hughes, P., Brierley, S., Castro Kraftchenko, J., Harrington, A., & Blackshaw, L. (2012). Experimental colitis models. In A. Szallasi, & T. Biro (Eds.), Methods in Pharmacology and Toxicology: TRP Channels in Drug Discovery, Volume II (Vol. 2, 1 ed., pp. 379-390). USA: Springer. DOI Scopus1
  2012	Brierley, S., Hughes, P., Harrington, A., & Blackshaw, L. (2012). Innervation of the gastrointestinal tract by spinal and vagal afferent nerves. In L. Johnson, F. Ghishan, J. Kaunitz, J. Merchant, H. Said, & J. Wood (Eds.), Physiology of the Gastrointestinal Tract, Volume 1, Fifth Edition (Vol. 1, 5 ed., pp. 703-729). United Kingdom: Elsevier. DOI Scopus16
  2012	Brierley, S. M., Hughes, P., Harrington, A., & Blackshaw, L. A. (2012). Innervation of the Gastrointestinal Tract by Spinal and Vagal Afferent Nerves. In Physiology of the Gastrointestinal Tract, Two Volume Set (pp. 703-731). DOI Scopus2

• Conference Papers

  Year	Citation
  2018	Hughes, P., Wardill, H., Choo, J., Dmochowska, N., Campaniello, M., Mavrangelos, C., . . . Rogers, G. (2018). Acute colitis chronically alters epithelial barrier and adaptive and innate immune responses to subsequent colitis re-activation independently of shifts in microbiota composition. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY.
  2016	Bashashati, M., Moossavi, S., Rezaei, N., Moraveji, S., Cremon, C., Hughes, P. A., . . . Barbara, G. (2016). Colonic Immune Cells in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis. In GASTROENTEROLOGY Vol. 150 (pp. S951-S952). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. DOI
  2014	Hughes, P. A., Mikocka-Walus, A. A., Moretta, M., Pilichiewicz, A. N., Bampton, P. A., & Andrews, J. M. (2014). Cognitive Behavioural Therapy (CBT) Influences Innate and Adaptive Inflammatory Responsiveness in IBD Patients With Clinical Remission Sustained Over 6 Months: A Randomised Control Trial. In GASTROENTEROLOGY Vol. 146 (pp. S593). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
  2013	Hughes, P. A., Harrington, A. M., Castro, J., Isaacs, N. J., Moretta, M., Hicks, G. A., . . . Brierley, S. M. (2013). Increased Efficacy of the Peripherally-Restricted Selective Kappa-Opioid Receptor Agonist, Asimadoline, in Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 144 (pp. S934-S935). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
  2012	Hughes, P. A., Isaacs, N. J., Moretta, M., Hicks, G. A., Urso, D. M., Blackshaw, L. A., & Brierley, S. M. (2012). Identification of Kappa Opioid Receptors on Colonic Sensory Nerves and Their Up-Regulation in a Mouse Model of Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S702). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
  2012	Castro, J., Harrington, A. M., Hughes, P. A., Martin, C., Silos-Santiago, A., Kurtz, C. B., . . . Brierley, S. M. (2012). Mechanism of Action for Linaclotide Induced Abdominal Pain Relief. In GASTROENTEROLOGY Vol. 142 (pp. S699). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. WoS5
  2011	Castro, J., Martin, C., Hughes, P. A., Silos-Santiago, A., Kurtz, C. B., Blackshaw, L. A., & Brierley, S. M. (2011). A Novel Role of Cyclic GMP in Colonic Sensory Neurotransmission in Healthy and TNBS-Treated Mice. In GASTROENTEROLOGY Vol. 140 (pp. S538). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. WoS18
  2011	Castro, J., Harrington, A., Hughes, P. A., Martin, C., Page, A. J., Blackshaw, L. A., & Brierley, S. M. (2011). Nitric Oxide Mechanism of Action on Visceral Nociceptors. In GASTROENTEROLOGY Vol. 140 (pp. S536). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
  2011	Adam, B., Liebregts, T., Bredack, C., Brierley, S. M., Hughes, P. A., Blackshaw, L. A., . . . Holtmann, G. (2011). Small Bowel Homing T Cells Are Associated With Symptoms and Delayed Gastric Emptying in Functional Dyspepsia. In GASTROENTEROLOGY Vol. 140 (pp. S139). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
  2011	Harrington, A., Brierley, S. M., Castro, J., Hughes, P. A., & Blackshaw, L. A. (2011). Identification of Colonic Afferent Central Terminals and Changes Following Colonic Inflammation. In GASTROENTEROLOGY Vol. 140 (pp. S131). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
  2010	Hughes, P., Brierley, S., Harrington, A., Castro, J., Martin, C., & Blackshaw, L. (2010). Differential coupling of cytokine receptors to sensory neurons in health and post inflammation. In Proceedings Vol. 138 (pp. 136-137). W B SAUNDERS CO-ELSEVIER INC. DOI
  2010	Mikocka-Walus, A. A., Bond, M., Holloway, R. H., Persson, J., Pilichiewicz, A. N., Hughes, P. A., . . . Andrews, J. M. (2010). Does Cognitive-Behavioural Therapy (CBT) Improve Outcomes in Inflammatory Bowel Disease (IBD)? Initial Feasibility Report on a Pilot Randomised Controlled Trial. In GASTROENTEROLOGY Vol. 138 (pp. S521-S522). W B SAUNDERS CO-ELSEVIER INC. WoS5
  2009	Harrington, A., Hughes, P., Martin, C., Isaacs, N., Brierley, S., & Blackshaw, L. (2009). Localisation and function of transient receptor potential ion channel melastatin subtype 8 (TRPM8) in mouse colonic primary afferent nerve fibers. In Autonomic neuroscience Vol. 149 (pp. 29). United States: Elsevier B.V.. DOI
  2009	Brierley, S., Harrington, A., Hughes, P., Page, A., Corey, D., Kwan, K., . . . Blackshaw, L. (2009). TRPA1 contributes to specific mechanotransduction currents in isolated DRG neurons. In TRP Channels: From Sensory Signaling to Human Disease (pp. 76). Stockholm, Sweden.
  2009	Hughes, P. A., Brierley, S. M., Persson, J., Liebregts, T., Adam, B., Holtmann, G., & Blackshaw, L. A. (2009). Immune Cell Supernatants from IBS Patient Subtypes Differentially Affect Visceral Afferent Mechanosensitivity. In GASTROENTEROLOGY Vol. 136 (pp. A75). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
  2008	Hughes, P. A., Brierley, S. M., Liebregts, T., Adam, B., Holtmann, G. J., & Blackshaw, L. A. (2008). Sensitization of visceral afferents by immune cell supernatants from IBS patients. In GASTROENTEROLOGY Vol. 134 (pp. A553). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
  2008	Hughes, P. A., Brierley, S. M., & Blackshaw, L. A. (2008). Delayed post-inflammatory hypersensitivity in sub-populations of colonic afferents. In GASTROENTEROLOGY Vol. 134 (pp. A553). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
  2008	Brierley, S. M., Hughes, P. A., Page, A. J., O'Donnell, T. A., Martin, C. M., Kwan, K. Y., . . . Blackshaw, L. A. (2008). Novel and specific roles for the ion channel TRPA1 in visceral sensory transduction. In GASTROENTEROLOGY Vol. 134 (pp. A8). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. WoS4
  2007	Brierley, S. M., Hughes, P. A., Page, A. J., & Blackshaw, L. A. (2007). Mechanical hypersensitivity of mouse colonic afferents after activation of the ion channel Trpa1. In GASTROENTEROLOGY Vol. 132 (pp. A600). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
  2007	Brierley, S. M., Hughes, P. A., Page, A. J., Adam, B., Liebregts, T., Holtmann, G., . . . Blackshaw, L. (2007). Mice lacking the TRPV4 ion channel display major deficits in spinal colonic but not vagal gastroesophageal mechanosensory function. In GASTROENTEROLOGY Vol. 132 (pp. A156). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. WoS2

• Conference Items

  Year	Citation
  2018	Hughes, P., Wardill, H., Dmochowska, N., Mavrangelos, C., Campaniello, M., Bowen, J., . . . Andrews, J. (2018). Proteolytic activation of IL-1 beta impairs epithelial barrier integrity in the ulcerative colitis lumen. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Brisbane, Qld: Wiley.
  2018	Dmochowska, N., Campaniello, M., Mavrangelos, C., Wardill, H., Takhar, P., Keller, M., . . . Hughes, P. (2018). "In vivo" PET imaging of innate immune responses in murine DSS colitis. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY.
  2017	Costello, S., Waters, O., Bryant, R., Katsikeros, R., Makanyanga, J., Schoeman, M., . . . Andrews, J. (2017). Short duration, low intensity pooled faecal microbiota transplantation induces remission in patients with mild-moderately active ulcerative colitis: a randomised controlled trial. Poster session presented at the meeting of JOURNAL OF CROHNS & COLITIS. OXFORD UNIV PRESS. WoS26
  2017	Costello, S., Mashei, C., Bryant, R., Katsikeros, R., Waters, O., Makanyanga, J., . . . Andrews, J. (2017). Comparison of dietary nutrient and food additive intake between patients with moderately active ulcerative colitis, healthy stool donors and the general Australian population. Poster session presented at the meeting of JOURNAL OF CROHNS & COLITIS. OXFORD UNIV PRESS.
  2017	Wardill, H., Bowen, J., Dmochowska, N., Campaniello, M., Mavrangelos, C., Holloway, R., . . . Hughes, P. (2017). Faecal supernatants from diarrhoea predominant Irritable Bowel Syndrome (IBS) patients disrupt colonic epithelial barrier function and directly activate colo-rectal afferent nerves. Poster session presented at the meeting of Abstracts of the NeuroGASTRO 2017 Congress, as published in Neurogastroenterology and Motility. Cork, Ireland: Wiley. DOI
  2017	Wardill, H. R., Dmochowska, N., Campaniello, M. A., Mavrangelos, C., Bowen, J. M., Andrews, J. M., . . . Hughes, P. A. (2017). Fecal supernatants from active ulcerative colitis patients impair colonic epithelial barrier integrity and activate pelvic mucosal extrinsic afferent nerves. Poster session presented at the meeting of FASEB Journal. Chicago, IL: Federation of American Societies for Experimental Biology.
  2017	Mikocka-Walus, A., Hughes, P., Bampton, P., Gordon, A., Campaniello, M., Mavrangelos, C., . . . Andrews, J. (2017). FLUOXETINE FOR MAINTENANCE OF REMISSION AND TO IMPROVE QUALITY OF LIFE IN PATIENTS WITH CROHN'S DISEASE: A PILOT RANDOMIZED PLACEBO-CONTROLLED TRIAL. Poster session presented at the meeting of AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY. SAGE PUBLICATIONS LTD.
  2017	Mikocka-Walus, A., Bampton, P., Hetzel, D., Hughes, P., Esterman, A., & Andrews, J. (2017). COGNITIVE BEHAVIOURAL THERAPY FOR INFLAMMATORY BOWEL DISEASE: 24-MONTH DATA FROM A RANDOMIZED CONTROLLED TRIAL. Poster session presented at the meeting of AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY. SAGE PUBLICATIONS LTD.
  2017	Mavrangelos, C., Campaniello, M., Andrews, J., Bampton, P., & Hughes, P. (2017). Longitudinal analysis of IBS patients reveals that acquired immune responses are inhibited in symptom flare vs symptom free. Poster session presented at the meeting of Abstracts of the NeuroGASTRO 2017 Congress, as published in Neurogastroenterology and Motility. Cork, Ireland: Wiley. DOI
  2017	Costello, S. P., Waters, O., Bryant, R. V., Katsikeros, R., Makanyanga, J., Schoeman, M., . . . Andrews, J. M. (2017). SHORT DURATION, LOW INTENSITY, POOLED FECAL MICROBIOTA TRANSPLANTATION INDUCES REMISSION IN PATIENTS WITH MILD-MODERATELY ACTIVE ULCERATIVE COLITIS: A RANDOMISED CONTROLLED TRIAL. Poster session presented at the meeting of GASTROENTEROLOGY. Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. DOI WoS37
  2016	Adams, J. H., Baker, L., Cepeda, J., Hughes, P., Silber, A., & Ahmed, R. (2016). Management of Maternal Cardiac Arrest in the Third Trimester of Pregnancy: A Simulation-Based Pilot Study. Poster session presented at the meeting of OBSTETRICS AND GYNECOLOGY. Washington, DC: LIPPINCOTT WILLIAMS & WILKINS. DOI
  2016	Campaniello, M., Mavrangelos, C., Dimasi, D., Hofma, B., Eade, S., Smid, S., . . . Hughes, P. A. (2016). Innate cell infiltration during acute TNBS colitis alters enteric nerve activity. Poster session presented at the meeting of Gastroenterology. San Diego, CA: Elsevier Inc.. DOI
  2016	Campaniello, M., Mavrangelos, C., Bampton, P. A., Andrews, J. M., & Hughes, P. A. (2016). Expression of Gut Homing Markers on TReg Differs Between IBS and Remissive IBD. Poster session presented at the meeting of GASTROENTEROLOGY. San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. DOI
  2016	Mikocka-Walus, A., Andrews, J., Bampton, P., Hetzel, D., Hughes, P., & Esterman, A. (2016). Cognitive-behavioural therapy has no effect on disease activity but it improves quality of life in sub-groups of patients with inflammatory bowel disease short-term: a randomised controlled trial with a 24-month follow-up. Poster session presented at the meeting of JOURNAL OF CROHNS & COLITIS. OXFORD UNIV PRESS.
  2015	Hughes, P., & Campaniello, M. (2015). Distinct differences in the immune profile of acute, remissive and reactivated murine TNBS colitis. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. Istanbul, TURKEY: WILEY.
  2015	Malsch, P., Andratsch, M., Vogl, C., Link, A. S., Alzheimer, C., Brierley, S. M., . . . Kress, M. (2015). Functional interaction of signal transducer gp130 and TRPA1 for mechanonociception and neuropathic pain. Poster session presented at the meeting of ACTA PHYSIOLOGICA. WILEY-BLACKWELL.
  2014	Mikocka-Walus, A., Hughes, P., Moretta, M., Pilichiewicz, A., Long, H., Hetzel, D., . . . Andrews, J. (2014). Cognitive-behavioural therapy (CBT) improves inflammatory responsiveness but not mental health short term in IBD patients: A pilot randomised controlled trial. Poster session presented at the meeting of JOURNAL OF CROHNS & COLITIS. OXFORD UNIV PRESS. DOI WoS1
  2013	Hughes, P. A., Moretta, M., Bird, D., Grasby, D., Lim, A., Brierley, S. M., . . . Krumbiegel, D. (2013). Beta-endorphin secretion by monocyte/macrophages is deficient in irritable bowel syndrome: a contributor to visceral hypersensitivity?. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
  2013	Hughes, P., Moretta, M., Lim, A., Grasby, D., Bird, D., Bampton, P., . . . Krumbiegel, D. (2013). Lack of macrophage/monocyte derived β-endorphin contributes toward sensations of pain/discomfort in Irritable Bowel Syndrome. Poster session presented at the meeting of JOURNAL OF IMMUNOLOGY. Honolulu, HI: AMER ASSOC IMMUNOLOGISTS.
  2013	Brierley, S. M., Castro, J., Harrington, A., Hughes, P., Martin, C., Silos-Santiago, A., . . . Blackshaw, A. (2013). MECHANISM OF ACTION FOR LINACLOTIDE-INDUCED ABDOMINAL PAIN RELIEF. Poster session presented at the meeting of GUT. Glasgow, SCOTLAND: BMJ PUBLISHING GROUP. DOI
  2012	Hughes, P., Nicholson, I., Bird, D., To, S., Isaacs, N., Grasby, D., . . . Krumbiegel, D. (2012). C-IBS patients lack monocyte derived β-endorphin which results in disinhibition of colonic afferent mechanosensitivity. Poster session presented at the meeting of Gastroenterology. USA: WB Saunders. DOI
  2012	Hughes, P. A., Bird, D., Brierley, S. M., Persson, J., Moretta, M., Blackshaw, L. A., . . . Andrews, J. M. (2012). TNF-alpha from gut homing memory T cells and monocytes sensitises colonic sensory afferents in IBS-D. Poster session presented at the meeting of Neurogastroenterology and Motility: Supplement. Bologna, Italy: WILEY-BLACKWELL.
  2011	Castro, J., Hughes, P. A., Martin, C. M., Silos-Santiago, A., Kurtz, C., Black-Shaw, L. A., & Brierley, S. M. (2011). Extracellular cGMP has contrasting effects on colonic afferent mechanosensitivity in control and tnbs-treated mice. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
  2011	Hughes, P., Harrington, A., Brierley, S., Maldeniya, M., Martin, C., Persson, J., . . . Blackshaw, L. (2011). Cytokine modulation of visceral afferents via cation channels is switched in chronic visceral hypersensitivity. Poster session presented at the meeting of Gastroenterology. Chicago, IL: W B Saunders Co. DOI
  2010	Brierley, S., Castro Kraftchenko, J., Martin, C., Harrington, A., Hughes, P., & Blackshaw, L. (2010). Differential regulation of TRP channel function in acute and chronic mechanical hypersensitivity. Poster session presented at the meeting of Abstract of theJoint International Neurogastroenterology and Motility Meeting, as published in Neurogastroenterology and Motility. Boston, MA, USA: Wiley-Blackwell Publishing. DOI
  2010	Mikocka-Walus, A. A., Bond, M., Holloway, R. H. H., Pilichiewicz, A., Persson, J., Collins, K., . . . Andrews, J. M. (2010). Cognitive behavioural therapy (CBT) as a treatment modality in inflammatory bowel disease (IBD): early experience and preliminary results. Poster session presented at the meeting of JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. WILEY-BLACKWELL PUBLISHING, INC.

PhD and honors projects are available for motivated students. Please contact Dr. Hughes for more information

• Past Higher Degree by Research Supervision (University of Adelaide)

  Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
  2018 - 2022	Co-Supervisor	Exploring the Effects of Toll-Like Receptor 4 Antagonism on Gastrointestinal Mucositis and Tumour Activity	Doctor of Philosophy	Doctorate	Full Time	Miss Shu Yie Janine Tam
  2016 - 2020	Principal Supervisor	Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease	Doctor of Philosophy	Doctorate	Full Time	Miss Nicole Dmochowska
  2013 - 2019	Co-Supervisor	Faecal Microbiota Transplantation for the Treatment of Active Ulcerative Colitis	Doctor of Philosophy	Doctorate	Full Time	APrf Samuel Paul Costello

• Committee Memberships

  Date	Role	Committee	Institution	Country
  2017 - ongoing	Council	Australasian Neurogastroenterology and Motility Association (ANGMA)	-	Australia

• Memberships

  Date	Role	Membership	Country
  2015 - ongoing	Member	GENIEUR (Genes in Irritable Bowel Syndrome - European Network)	-

• Email: patrick.hughes@adelaide.edu.au