Philip Gregory

Philip Gregory

Adelaide Medical School

Faculty of Health and Medical Sciences

Asoociate Professor Philip GregoryHead, Gene Regulation in Cancer LaboratoryCentre for Cancer Biology: An Alliance between University of South Australia and SA Pathology.A/Prof Philip Gregory is researching the new and exciting area of ‘microRNAs’. These are tiny particles of genetic material that exist inside cells and regulate how our genes are switched on and off. MicroRNAs were only discovered relatively recently and their role in the development of breast cancer is just beginning to be explored.A/Prof Gregory is interested in how microRNAs influence breast and prostate cancer cells to spread to other parts of the body – a process known as metastasis. Metastatic (or secondary) breast cancer is currently very difficult to treat effectively, so understanding how metastasis occurs could lead to the development of more effective treatments and improved prevention strategies.Epithelial cell plasticity (or epithelial-mesenchymal transition, EMT) plays a major role in the driving cancer cell invasion and their metastasis to other organs. My lab is examining how EMT and cancer metastasis are regulated by microRNAs. In particular, our research focusses on how microRNAs alter the cancer cell transcriptome using in vitro and in vivo cancer models coupled with next generation sequencing.

Gene Regulation in Cancer Laboratory

The Gene Regulation in Cancer Laboratory within the Centre for Cancer Biology investigates the molecular mechanisms controlling tumour cell plasticity in breast and prostate cancer, with a specific focus on the role of microRNAs and alternative splicing in this process. A/Prof. Gregory's groundbreaking research identified the miR-200 family as central regulators of epithelial-mesenchymal transition (Nature Cell Biology, >4000 citations). His lab uses the latest advances in transcriptomics coupled with in vitro and in vivo cancer models to investigate how cancer cells progress towards a metastatic state.

Project 1

Title: Function of alternative splice variants in cancer cell plasticity

Description: Using CRISPR gene editing, this project will uncover the function of alternatively spliced variants that are strongly induced in invasive cancer cells but whose function has not yet been investigated.

Projects available for: Honours and HDR

Location: Centre for Cancer Biology

Research Project Start: Semester 1 and 2

 

Project 2

Title: How microRNAs regulate breast cancer metastasis

Description: This project will determine the target genes of miRNAs that function in breast cancer progression and metastasis using cell culture and animal models.

Projects available for: Honours and HDR

Location: Centre for Cancer Biology

Research Project Start: Semester 1 and 2

  • Journals
    Year Citation
    2025 Hindes, M. T., McElligott, A. M., Best, O. G., Ward, M. P., Selemidis, S., Miles, M. A., . . . Brooks, D. A. (2025). Metabolic reprogramming, malignant transformation and metastasis: Lessons from chronic lymphocytic leukaemia and prostate cancer. Cancer Letters, 611, 217441-1-217441-18.
    DOI Scopus3 Europe PMC2
    2025 Nturubika, B. D. D., Logan, J., Johnson, I. R. D., Moore, C., Li, K. L., Tang, J., . . . Brooks, D. A. (2025). Components of the Endosome-Lysosome Vesicular Machinery as Drivers of the Metastatic Cascade in Prostate Cancer. Cancers, 17(1), 31 pages.
    DOI Scopus1 Europe PMC1
    2025 Liu, D., Wang, X., Zhang, Y., Zuo, S., Chereda, B., Gregory, P. A., . . . Goodall, G. J. (2025). A Dual-Selection System for Enhanced Efficiency and Fidelity of Circular RNA Overexpression. Journal of Molecular Biology, 437(10), 10 pages.
    DOI Scopus1
    2025 Orang, A., Warnock, N. I., Migault, M., Dredge, B. K., Bert, A. G., Bracken, J. M., . . . Bracken, C. P. (2025). Chasing non-existent "microRNAs" in cancer. Oncogenesis, 14(1), 10-1-10-9.
    DOI Europe PMC1
    2025 Toubia, J., Kusay, Y., Maqsood, M., Warnock, N. I., Lawrence, D. M., Bracken, C. P., . . . Schreiber, A. W. (2025). TRanscriptome ANalysis of StratifiEd CohorTs (TRANSECT) enables automated assessment of global gene regulation linked to disparate expression in user defined genes and gene sets. Nar Genomics and Bioinformatics, 7(2), 13 pages.
    DOI
    2024 Bracken, C. P., Goodall, G. J., & Gregory, P. A. (2024). RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer (vol 102, pg 4, 2024). SEMINARS IN CANCER BIOLOGY, 106, 13-14.
    DOI
    2024 Liu, D., Dredge, B. K., Bert, A. G., Pillman, K. A., Toubia, J., Guo, W., . . . Goodall, G. J. (2024). ESRP1 controls biogenesis and function of a large abundant multiexon circRNA. Nucleic Acids Research, 52(3), 1387-1403.
    DOI Scopus11 Europe PMC12
    2024 Neumann, D. P., Phillips, C. A., Lumb, R., Palethorpe, H. M., Ramani, Y., Hollier, B. G., . . . Gregory, P. A. (2024). Quaking isoforms cooperate to promote the mesenchymal phenotype. Molecular biology of the cell, 35(2), ar17-1-ar17-12.
    DOI Scopus2 Europe PMC2
    2024 Neumann, D. P., Pillman, K. A., Dredge, B. K., Bert, A. G., Phillips, C. A., Lumb, R., . . . Gregory, P. A. (2024). The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking. RNA Biology, 21(1), 1-11.
    DOI Scopus8 Europe PMC17
    2024 Thompson, E. J., Escarbe, S., Tvorogov, D., Farshid, G., Gregory, P. A., Khew-Goodall, Y., . . . Bonder, C. S. (2024). Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis. Growth Factors, 42(2), 49-61.
    DOI
    2024 Bracken, C. P., Goodall, G. J., & Gregory, P. A. (2024). RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer. Seminars in Cancer Biology, 102-103, 4-16.
    DOI Scopus12 Europe PMC9
    2024 Nturubika, B. D., Guardia, C. M., Gershlick, D. C., Logan, J. M., Martini, C., Heatlie, J. K., . . . Johnson, I. R. D. (2024). Altered expression of vesicular trafficking machinery in prostate cancer affects lysosomal dynamics and provides insight into the underlying biology and disease progression. British Journal of Cancer, 131(8), 1263-1278.
    DOI Scopus2 Europe PMC2
    2023 Sapkota, S., Pillman, K. A., Dredge, B. K., Liu, D., Bracken, J. M., Kachooei, S. A., . . . Goodall, G. J. (2023). On the rules of engagement for microRNAs targeting protein coding regions. Nucleic Acids Research, 51(18), 9938-9951.
    DOI Scopus10 Europe PMC10
    2023 Orang, A., Dredge, B. K., Liu, C. Y., Bracken, J. M., Chen, C. -H., Sourdin, L., . . . Bracken, C. P. (2023). Basonuclin-2 regulates extracellular matrix production and degradation. Life Science Alliance, 6(10), e202301984-1-e202301984-17.
    DOI Scopus2 Europe PMC6
    2023 King, J., Evans, C., Kadolsky, U., Norret, M., Iqbal, M., Mercé, C., . . . Smith, N. (2023). Metastable Intermediates Identified in Epithelial to Mesenchymal Transition are Regulated by G-Quadruplex DNA Structures.
    DOI Europe PMC1
    2022 Tang, Y. H., Rockstroh, A., Sokolowski, K. A., Lynam, L. R., Lehman, M., Thompson, E. W., . . . Hollier, B. G. (2022). Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation. Breast Cancer Research, 24(1), 17 pages.
    DOI Scopus22 WoS8 Europe PMC19
    2022 Neumann, D. P., Goodall, G. J., & Gregory, P. A. (2022). The Quaking RNA-binding proteins as regulators of cell differentiation. Wiley interdisciplinary reviews. RNA, 13(6), e1724-1-e1724-19.
    DOI Scopus26 WoS4 Europe PMC27
    2022 Chi, L. H., Cross, R. S. N., Redvers, R. P., Davis, M., Hediyeh-Zadeh, S., Mathivanan, S., . . . Anderson, R. L. (2022). MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms. Oncogenesis, 11(1), 1-12.
    DOI Scopus23 WoS4 Europe PMC18
    2021 Fernandes, R. C., Toubia, J., Townley, S., Hanson, A. R., Dredge, B. K., Pillman, K. A., . . . Selth, L. A. (2021). Post-transcriptional gene regulation by microRNA-194 promotes neuroendocrine transdifferentiation in prostate cancer. Cell Reports, 34(1), 1-17.
    DOI Scopus38 WoS23 Europe PMC35
    2021 Chan, K. M., Gleadle, J. M., Gregory, P. A., Phillips, C. A., Safizadeh Shirazi, H., Whiteley, A., . . . Macgregor, M. (2021). Selective microfluidic capture and detection of prostate cancer cells from urine without digital rectal examination. Cancers, 13(21), 5544-1-5544-17.
    DOI Scopus10 WoS5 Europe PMC7
    2020 Saunders, K., Bert, A. G., Dredge, B. K., Toubia, J., Gregory, P. A., Pillman, K. A., . . . Bracken, C. P. (2020). Insufficiently complex unique-molecular identifiers (UMIs) distort small RNA sequencing. Scientific Reports, 10(1), 1-9.
    DOI Scopus13 WoS5 Europe PMC9
    2019 Pillman, K. A., Scheer, K. G., Hackett-Jones, E., Saunders, K., Bert, A. G., Toubia, J., . . . Bracken, C. P. (2019). Extensive transcriptional responses are co-ordinated by microRNAs as revealed by Exon-Intron Split Analysis (EISA). Nucleic Acids Research, 47(16), 14 pages.
    DOI Scopus8 WoS5 Europe PMC6
    2019 Gregory, P. A. (2019). The miR-200-Quaking axis functions in tumour angiogenesis. Oncogene, 38(41), 6767-6769.
    DOI Scopus4 WoS2 Europe PMC3
    2019 Pinweha, P., Phillips, C. A., Gregory, P. A., Li, X., Chuayboonya, P., Mongkolsiri, P., . . . Jitrapakdee, S. (2019). MicroRNA-143-3p targets pyruvate carboxylase expression and controls proliferation and migration of MDA-MB-231 cells. Archives of Biochemistry and Biophysics, 677, 10 pages.
    DOI Scopus15 WoS15 Europe PMC11
    2018 Cursons, J., Pillman, K. A., Scheer, K. G., Gregory, P. A., Foroutan, M., Hediyeh-Zadeh, S., . . . Davis, M. J. (2018). Combinatorial targeting by MicroRNAs co-ordinates post-transcriptional control of EMT. Cell Systems, 7(1), 77-91.
    DOI Scopus73 WoS58 Europe PMC64
    2018 Pillman, K. A., Phillips, C. A., Roslan, S., Toubia, J., Dredge, B. K., Bert, A. G., . . . Gregory, P. A. (2018). miR-200/375 control epithelial plasticity-associated alternative splicing by repressing the RNA-binding protein Quaking. EMBO Journal, 37(13), 20 pages.
    DOI Scopus87 WoS64 Europe PMC72
    2018 Neumann, D. P., Goodall, G. J., & Gregory, P. A. (2018). Regulation of splicing and circularisation of RNA in epithelial mesenchymal plasticity. Seminars in Cell and Developmental Biology, 75, 50-60.
    DOI Scopus22 WoS14 Europe PMC18
    2017 Selth, L., Das, R., Townley, S., Coutinho, I., Hanson, A., Centenera, M., . . . Tilley, W. (2017). A ZEB1-miR-375-YAP1 pathway regulates epithelial plasticity in prostate cancer. Oncogene, 36(1), 24-34.
    DOI Scopus94 WoS84 Europe PMC77
    2017 Das, R., Gregory, P. A., Fernandes, R. C., Denis, I., Wang, Q., Townley, S. L., . . . Selth, L. A. (2017). MicroRNA-194 promotes prostate cancer metastasis by inhibiting SOCS2. Cancer Research, 77(4), 1021-1034.
    DOI Scopus100 WoS88 Europe PMC82
    2017 Tse, B., Volpert, M., Ratther, E., Stylianou, N., Nouri, M., McGowan, K., . . . Hollier, B. (2017). Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality. Oncogene, 36(24), 3417-3427.
    DOI Scopus64 WoS53 Europe PMC56
    2017 Cursons, J., Pillman, K., Scheer, K., Gregory, P., Foroutan, M., Zadeh, S. H., . . . Davis, M. (2017). Post-transcriptional control of EMT is coordinated through combinatorial targeting by multiple microRNAs.
    DOI
    2015 Conn, S., Pillman, K., Toubia, J., Conn, V., Salmanidis, M., Phillips, C., . . . Goodall, G. (2015). The RNA binding protein quaking regulates formation of circRNAs. Cell, 160(6), 1125-1134.
    DOI Scopus1757 WoS1418 Europe PMC1468
    2014 Das, R., Gregory, P., Hollier, B., Tilley, W., & Selth, L. (2014). Epithelial plasticity in prostate cancer: principles and clinical perspectives. Trends in Molecular Medicine, 20(11), 643-651.
    DOI Scopus22 WoS20 Europe PMC17
    2014 Young, J. A., Ting, K. K., Li, J., Moller, T., Dunn, L., Lu, Y., . . . Gamble, J. R. (2014). Erratum: Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted mirna antagonists of mir-27 (Blood (2012) 122:16 (2911-2919)). Blood, 124(19), 3034.
    DOI
    2014 Zafar, A., Wu, F., Hardy, K., Li, J., Juan Tu, W., McCuaig, R., . . . Rao, S. (2014). Chromatinized protein kinase C-θ directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells. Molecular and Cellular Biology, 34(16), 2961-2980.
    DOI Scopus32 WoS30 Europe PMC30
    2014 Bracken, C. P., Li, X., Wright, J. A., Lawrence, D., Pillman, K. A., Salmanidis, M., . . . Goodall, G. (2014). Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion. The EMBO Journal, 33(18), 1979-2134.
    DOI Scopus124 WoS116 Europe PMC108
    2014 Kolesnikoff, N., Attema, J., Roslan, S., Bert, A., Schwarz, Q., Gregory, P., & Goodall, G. (2014). Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition. Journal of Biological Chemistry, 289(16), 11194-11205.
    DOI Scopus61 WoS52 Europe PMC49
    2014 Yip, K., Kolesnikoff, N., Yu, C., Hauschild, N., Taing, H., Biggs, L., . . . Grimbaldeston, M. (2014). Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation. Journal of Allergy and Clinical Immunology, 133(5), 1356-1379.
    DOI Scopus100 WoS84 Europe PMC72
    2014 Li, X., Roslan, S., Johnstone, C., Wright, J., Bracken, C., Anderson, M., . . . Khew-Goodall, Y. (2014). MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways. Oncogene, 33(31), 4077-4088.
    DOI Scopus108 WoS102 Europe PMC93
    2013 Young, J., Ting, K., Li, J., Moller, T., Dunn, L., Lu, Y., . . . Gamble, J. (2013). Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. Blood, 122(16), 2911-2919.
    DOI Scopus62 WoS54 Europe PMC50
    2013 Lim, Y., Wright, J., Attema, J., Gregory, P., Bert, A., Smith, E., . . . Goodall, G. (2013). Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state. Journal of Cell Science, 126(10), 2256-2266.
    DOI Scopus171 WoS154 Europe PMC140
    2013 Neilsen, P., Noll, J., Mattiske, S., Bracken, C., Gregory, P., Schulz, R., . . . Callen, D. (2013). Mutant p53 drives invasion in breast tumors through up-regulation of miR-155. Oncogene, 32(24), 2992-3000.
    DOI Scopus152 WoS141 Europe PMC127
    2013 Yu, Y., Gray, B., Lowe, H., Halmagyi, G. M., & Ng, M. (2013). Dual modality intravascular imaging of unstable, symptomatic but "hemodynamically insignificant" carotid stenosis. Journal of Neurology, 260(7), 1934-1935.
    DOI
    2012 Ahn, Y., Gibbons, D., Chakravarti, D., Creighton, C., Rizvi, Z., Adams, H., . . . Kurie, J. (2012). ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. Journal of Clinical Investigation, 122(9), 3170-3183.
    DOI Scopus143 WoS132 Europe PMC131
    2012 Callegari, S., Gregory, P., Sykes, M., Bellon, J., Andrews, S., McKinnon, R., & de Barros Lopes, M. (2012). Polymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastatin toxicity. PLoS Genetics, 8(6), 1-12.
    DOI Scopus5 WoS5 Europe PMC5
    2011 Matsushima, K., Isomoto, H., Yamaguchi, N., Inoue, N., Machida, H., Nakayama, T., . . . Nakao, K. (2011). MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells. Journal of Translational Medicine, 9(30), 1-12.
    DOI Scopus129 WoS118 Europe PMC102
    2011 Gregory, P., Bracken, C., Smith, E., Bert, A., Wright, J., Roslan, S., . . . Goodall, G. (2011). An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Molecular Biology of the Cell, 22(10), 1686-1698.
    DOI Scopus506 WoS436 Europe PMC435
    2011 Yang, Y., Ahn, Y., Gibbons, D., Zang, Y., Lin, W., Thilaganathan, N., . . . Kurie, J. (2011). The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. Journal of Clinical Investigation, 121(4), 1373-1385.
    DOI Scopus183 WoS159 Europe PMC145
    2010 Hu, D., Gardner-Stephen, D., Severi, G., Gregory, P., Treloar, J., Giles, G., . . . MacKenzie, P. (2010). A novel polymorphism in a forkhead box A1 (FOXA1) binding site of the human UDP glucuronosyltransferase 2B17 gene modulates promoter activity and is associated with altered levels of circulating androstane-3α,17β-diol glucuronide. Molecular Pharmacology, 78(4), 714-722.
    DOI Scopus28 WoS26 Europe PMC25
    2009 Gibbons, D., Lin, W., Creighton, C., Rizvi, Z., Gregory, P., Goodall, G., . . . Kurie, J. (2009). Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes & Development, 23(18), 2140-2151.
    DOI Scopus449 WoS383 Europe PMC377
    2009 Bracken, C., Gregory, P., Khew-Goodall, Y., & Goodall, G. (2009). The role of microRNAs in metastasis and epithelial-mesenchymal transition. Cellular and Molecular Life Sciences, 66(10), 1682-1699.
    DOI Scopus107 WoS94 Europe PMC87
    2008 Paterson, E., Kolesnikoff, N., Gregory, P., Bert, A., Khew-Goodall, Y., & Goodall, G. (2008). The microRNA-200 Family Regulates Epithelial to Mesenchymal Transition. The Scientific World Journal, 8, 901-904.
    DOI Scopus76 WoS69 Europe PMC59
    2008 Gregory, P., Bracken, C., Bert, A., & Goodall, G. (2008). MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle, 7(20), 3112-3117.
    DOI Scopus446 WoS393 Europe PMC362
    2008 Bracken, C., Gregory, P., Kolesnikoff, N., Bert, A., Wang, J., Shannon, M., & Goodall, G. (2008). A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Research, 68(19), 7846-7854.
    DOI Scopus947 WoS846 Europe PMC805
    2008 Gregory, P., Bert, A., Paterson, E., Barry, S., Tsykin, A., Farshid, G., . . . Goodall, G. (2008). The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nature Cell Biology, 10(5), 593-601.
    DOI Scopus3429 WoS3067 Europe PMC2857
    2006 Gregory, P. A., Gardner-Stephen, D. A., Rogers, A., Michael, M. Z., & Mackenzie, P. I. (2006). The caudal-related homeodomain protein Cdx2 and hepatocyte nuclear factor 1α cooperatively regulate the UDP-glucuronosyltransferase 2B7 gene promoter. Pharmacogenetics and Genomics, 16(7), 527-536.
    DOI Scopus21 WoS18 Europe PMC16
    2005 Gardner-Stephen, D. A., Gregory, P. A., & Mackenzie, P. I. (2005). Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genes. Methods in Enzymology, 400, 22-46.
    DOI Scopus16 Europe PMC13
    2004 Gregory, P. A., Lewinsky, R. H., Gardner-Stephen, D. A., & Mackenzie, P. I. (2004). Regulation of UDP glucuronosyltransferases in the gastrointestinal tract. Toxicology and Applied Pharmacology, 199(3), 354-363.
    DOI Scopus109 WoS101 Europe PMC80
    2004 Gregory, P. A., Lewinsky, R. H., Gardner-Stephen, D. A., & Mackenzie, P. I. (2004). Coordinate Regulation of the Human UDP-Glucuronosyltransferase 1A8, 1A9, and 1A10 Genes by Hepatocyte Nuclear Factor 1α and the Caudal-Related Homeodomain Protein 2. Molecular Pharmacology, 65(4), 953-963.
    DOI Scopus69 WoS62 Europe PMC53
    2003 Mackenzie, P. I., Gregory, P. A., Gardner-Stephen, D. A., Lewinsky, R. H., Jorgensen, B. R., Nishiyama, T., . . . Radominska-Pandya, A. (2003). Regulation of UDP glucuronosyltransferase genes. Current Drug Metabolism, 4(3), 249-257.
    DOI Scopus107 WoS93 Europe PMC73
    2003 Gregory, P. A., Gardner-Stephen, D. A., Lewinsky, R. H., Duncliffe, K. N., & Mackenzie, P. I. (2003). Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: Differential regulation through an initiator-like region. Journal of Biological Chemistry, 278(38), 36107-36114.
    DOI Scopus27 WoS25 Europe PMC20
    2002 Gregory, P. A., & Mackenzie, P. I. (2002). The homeodomain Pbx2-Prep1 complex modulates hepatocyte nuclear factor 1α-mediated activation of the UDP-glucuronosyltransferase 2B17 gene. Molecular Pharmacology, 62(1), 154-161.
    DOI Scopus29 WoS26 Europe PMC17
    2000 Gregory, P. A., Hansen, A. J., & Mackenzie, P. I. (2000). Tissue specific differences in the regulation of the UDP glucuronosyltransferase 2B17 gene promoter. Pharmacogenetics, 10(9), 809-820.
    DOI Scopus32 WoS28 Europe PMC20

  • Book Chapters
    Year Citation
    2013 Lecce, L., Lam, Y. T., & Ng, M. K. C. (2013). Role of sex steroids in angiogenesis. In Biochemical Basis and Therapeutic Implications of Angiogenesis (pp. 159-180). Springer New York.
    DOI Scopus2
    2013 Dunn, L. L., Chan, K. H., Ng, M. K. C., & Stocker, R. (2013). Vascular complications in diabetes. In Angiogenesis and Vascularisation Cellular and Molecular Mechanisms in Health and Diseases (pp. 313-337). Springer Vienna.
    DOI
    2005 Gardner-Stephen, D. A., Gregory, P. A., & Mackenzie, P. I. (2005). Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genes. In H. Sies, & L. Packer (Eds.), PHASE II CONJUGATION ENZYMES AND TRANSPORT SYSTEMS (Vol. 400, pp. 22-46). ELSEVIER ACADEMIC PRESS INC.
    DOI WoS17

  • Conference Papers
    Year Citation
    2018 Gomez, G. A., Woodcock, J. M., Tergaonkar, V., & Gregory, P. A. (2018). Meeting Report: The 8th Barossa Meeting - Cell Signaling in Cancer Medicine in the Barossa Valley, Australia. In Cell Death and Disease Vol. 9 (pp. 3 pages). England: SPRINGERNATURE.
    DOI
    2013 Hirsh, S. L., Bilek, M. M. M., Bax, D. V., Kondyurin, A., Kosobrodova, E., Tsoutas, K., . . . Weiss, A. S. (2013). Ion implanted, radical-rich surfaces for the rapid covalent immobilization of active biomolecules. In Aip Conference Proceedings Vol. 1525 (pp. 364-369). AIP.
    DOI Scopus4
    2012 Javadzadegan, A., Yong, A. S. C., Chang, M., Mansour, N., Ng, M. K. C., Behnia, M., & Kritharides, L. (2012). Comparison of four different fluid structure interaction models in a human coronary artery. In Proceedings of the 18th Australasian Fluid Mechanics Conference Afmc 2012.
    2005 Mackenzie, P. I., Gregory, P. A., Lewinsky, R. H., Yasmin, S. N., Height, T., McKinnon, R. A., & Gardner-Stephen, D. A. (2005). Polymorphic variations in the expression of the chemical detoxifying UDP glucuronosyltransferases. In Toxicology and Applied Pharmacology Vol. 207 (pp. 77-83). United States: Elsevier BV.
    DOI Scopus39 Europe PMC26
    2004 Wells, P. G., Mackenzie, P. I., Chowdhury, J. R., Guillemette, C., Gregory, P. A., Ishii, Y., . . . Ritter, J. K. (2004). Glucuronidation and the UDP-glucuronosyltransferases in health and disease. In Drug Metabolism and Disposition Vol. 32 (pp. 281-290). Netherlands: AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS.
    DOI Scopus230 WoS175 Europe PMC138

  • Conference Items
    Year Citation
    2011 Rizvi, Z. H., Kurie, J. M., Gibbons, D. L., Ann, Y. H., Creighton, C. J., Maria Cabanillas, A., . . . Gregory, P. A. (2011). The scribble polarity complex regulates tumor cell invasion by regulation of Zeb1 and dampening of p1-integrin signaling. Poster session presented at the meeting of Abstracts from the 2010 MRS-AACR Joint Conference on Metastasis, as published in Clinical & Experimental Metastasis. Philadelphia, PA: Springer.
    DOI
    2011 Gibbons, D. L., Yang, Y., Ahn, Y. -H., Creighton, C. J., Pertsemlidis, A., Gregory, P. A., . . . Kurie, J. M. (2011). NOTCH ACTIVATION DRIVES MICRORNA-200-DEPENDENT EMT & METASTASIS IN A MURINE MODEL OF NSCLC. Poster session presented at the meeting of JOURNAL OF THORACIC ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS.
    2011 Gibbons, D. L., Yang, Y., Ahn, Y. H., Creighton, C. J., Pertsemlidis, A., Gregory, P. A., . . . Kurie, J. M. (2011). EMT and metastasis in a murine model of NSCLC is dependent upon the Notch ligand Jagged2 activation of a GATA3-miR-200 feedback loop. Poster session presented at the meeting of Abstracts from the 2010 MRS-AACR Joint Conference on Metastasis, as published in Clinical & Experimental Metastasis. Philadelphia, PA: Springer.
    DOI
    2008 Gregory, P. A., Bracken, C. P., Bert, A. G., Paterson, E. L., Kolesnikoff, N., Farshid, G., . . . Goodall, G. J. (2008). Role of the miR-200 family in mediating EMT in response to TGF-β. Poster session presented at the meeting of Abstracts and Reviews of 7th Joint Conference of the International Cytokine Society and the International Society for Interferon and Cytokine Research, as published in Cytokine. Montreal, Canada: Elsevier.
    DOI

  • Preprint
    Year Citation
    2024 Kachooei, S. A., Bracken, J., Pillman, K., Gregory, P., & Bracken, C. (2024). More than half of annotated human miRNAs are never expressed at levels sufficient for biological function.
    DOI
    2022 Neumann, D., Pillman, K., Dredge, K., Bert, A., Bracken, C., Hollier, B., . . . Gregory, P. (2022). The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking.
    DOI

Recent Funding

1. GREGORY PA (CIA) Illuminating the functions of alternative splicing. ARC Discovery Project DP250103613. Funding for 2025-2027.

2. GREGORY PA (CIA) Uncovering the functions of splice variants driving breast cancer progression. NHMRC Ideas grant GNT2038882. Funding for 2025-2028.

3. GREGORY PA (CIA) Coordination of cellular plasticity in triple negative breast cancer. National Breast Cancer Foundation 2023/IIRS0098. Funding for 2024-2026.

4. GREGORY PA (CIA) Discovery of optimal targets to better diagnose and treat metastatic cancer. Beat Cancer Principal Research Fellowship. Funding for 2019-2021.

 

Biochemistry III Molecular and Structural Biology - Lectures and Tutorials on RNA Biology.

  • Past Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2014 - 2016 Co-Supervisor The Role of microRNA-194 and microRNA-375 in Prostate Cancer Metastasis Doctor of Philosophy Doctorate Full Time Dr Rajdeep Das
    2013 - 2014 Co-Supervisor Novel Fibroblast Growth Factor Receptor Signalling Pathways Regulating Neuronal Differentiation Master of Philosophy (Medical Science) Master Full Time Dr Yang Kong
    2012 - 2017 Co-Supervisor A Role for Bivalent Genes in Epithelial to Mesenchymal Transition Doctor of Philosophy Doctorate Part Time Mr Francisco Sadras
    2012 - 2024 Co-Supervisor Regulation of Breast Cancer Progression and Metastasis by MicroRNA-342-3p Doctor of Philosophy Doctorate Part Time Dr Victoria Kiriaki Arnet
    2010 - 2012 Co-Supervisor The miR 200 Family is Controlled by Epigenetic based Mechanisms and Mediates Transition Between Non Stem and Stem like Cell Phenotypes Doctor of Philosophy Doctorate Full Time Mr Yat Yuen Lim
    2008 - 2013 Co-Supervisor Regulation of the microRNA-200 family during epithelial to mesenchymal transition Doctor of Philosophy Doctorate Full Time Miss Natasha Kolesnikoff
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