Mahesh Umapathysivam
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
2024 Jalleh RJ, Plummer MP, Marathe CS, Umapathysivam MM, et al. Clinical Consequences of Delayed Gastric Emptying With GLP-1 Receptor Agonists and Tirzepatide. Journal of Clinical Endocrinology and Metabolism
2024 Jalleh RJ, Marathe CS, Rayner C, Umapathysivam MM, Physiology and Pharmacology of Effects of GLP-1-based Therapies on Gastric, Biliary and Intestinal Motility. Endocrinology
2024 Luppino, M. D., H. Nguyen, M. Smale, R. Madigan, M. G. Burt and MM Umapathysivam. Propofol-induced transient arginine vasopressin deficiency.
2024 J Tan, L Ephraums, J Inglis, H Nguyen, MM Umapathysivam et al. A cross-sectional study of capillary blood ketone concentrations in heart failure based on sodium-glucose co-transporter-2 inhibitor use and heart failure type Heart, Lung Circulation. Endocrinol Diabetes Metab Case Rep
2024 G Wittert & MM Umapathysivam Testosterone and the prevention of type 2 diabetes mellitus: Therapeutic implications from recent trials, Current Opinion in Endocrinology, Diabetes and Obesity
2024 R Jalleh, MM Umapathysivam et al Gastric emptying during and following resolution of moderate diabetic ketoacidosisin type 1 diabetes: a case series. BMJ Open Diabetes Research & Care
2024 MM Umapathysivam et al SGLT2 Inhibitor associated ketoacidosis vs Type 1 diabetes associated ketoacidosis. JAMA Network Open. 2024
2024 MM Umapathysivam et al. Euglycemic ketoacidosis in two Patients without Diabetes After Introduction of Sodium Glucose Co-transporter 2 inhibition, Diabetes Care. 2024
2023 R Jalleh, MM Umapathysivam, M Plummer, M Horowitz. Postprandial plasma GLP-1 levels are elevated in individuals with postprandial hypoglycaemia following Roux-en-Y gastric bypass – a systematic review. Reviews in Endocrine and Metabolic disorders
2023 A Hayes, M Stowasser, MM Umapathysivam, et al. Approach to the patient: Reninoma, Journal of clinical endocrinology 2023
2023 MM Umapathysivam et al Type 2 Diabetes risk alleles in Peptidyl-glycine Alpha-amidating Monooxygenase influence GLP-1 levels and response to GLP-1 Receptor Agonists. Preprint. Medarchive (Under review at Nat Metabolism– corrections required)
2022 Intraprocedural cortisol testing improves adrenal vein cannulation success and diagnostic accuracy in assessment of primary aldosteronism, in a medium throughput centre. MM Umapathysivam et al. Journal of Human Hypertension
2022 Effects of Androgens on glucose metabolism MM Umapathysivam, M Grossman, G Wittert. Clinical Endocrinology & Metabolism
2022 Letter to the Editor: Response to Hamblin et al Body Mass index is inversely associated with capillary ketones at time of colonoscopy: Implications for SGLT2i use. MM Umapathysivam et al. Clinical Endocrinology
2022 Accidental exposure to glimepiride from adulterated medication resulting in severe hypoglycaemia. A Hayes, MM Umapathysivam, D Torpy EDM case reports
2021 Response to Dahl et al: Oral semaglutide improves postprandial glucose and lipid metabolism, and delays gastric emptying, in subjects with type 2 diabetes. M Horowitz…MM Umapathysivam et al., Diabetes Obesity and Metabolism 2021
2019 Type 2 diabetes risk alleles in PAM cause pancreatic beta-cell dysfunction through direct effects on insulin availability and secretion. S Thomsen, A Raimondo, B Hastory, … MM Umapathysivam, … MI McCarthy A Gloyn et al. Nature genetics 2019
2013 The Effect of Prolonged Glucagon-Like Peptide-1 Receptor Stimulation on Gastric Emptying and Glycemia. MM Umapathysivam, M Lee, et al Diabetes 2013
2013 The effect of exogenous glucose – dependent insulinotropic polypeptide in combination with glucagon-like peptide-1 on glycaemia in critically ill patients, M Lee, JD Fraser,K Sundararajan, MM Umapathysivam, … M Horowitz, A Deane et al Diabetes Care. 2013
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Journals
Year Citation 2025 Jalleh, R. J., Plummer, M. P., Marathe, C. S., Umapathysivam, M. M., Quast, D. R., Rayner, C. K., . . . Nauck, M. A. (2025). Clinical Consequences of Delayed Gastric Emptying With GLP-1 Receptor Agonists and Tirzepatide. Journal of Clinical Endocrinology and Metabolism, 110(1), 1-15.
Scopus5 Europe PMC12025 Tan, J. Y., Ephraums, L. A., Inglis, J. M., Nguyen, H. T. T., Umapathysivam, M. M., Simpson, N. J., . . . Thynne, T. R. J. (2025). A Cross-Sectional Study of Capillary Blood Ketone Concentrations in Heart Failure Based on Sodium-Glucose Co-Transporter-2 Inhibitor Use and Heart Failure Type. Heart Lung and Circulation, 34(1), 34-39.
2025 Raven, L. M., Lever, W., MacIsaac, R. J., Greenfield, J. R., Deane, A., Plummer, M., & Umapathysivam, M. (2025). Heterogeneity in the management of diabetic ketoacidosis in Australia: a national survey. Internal Medicine Journal, 6 pages.
2024 Jalleh, R. J., Marathe, C. S., Rayner, C. K., Jones, K. L., Umapathysivam, M. M., Wu, T., . . . Horowitz, M. (2024). Physiology and pharmacology of effects of GLP-1 based therapies on gastric, biliary and intestinal motility. Endocrinology, 166(1), bqae155-1-bqae155-14.
Scopus2 Europe PMC12024 Luppino, M. D., Nguyen, H., Smale, M., Madigan, R., Burt, M. G., & Umapathysivam, M. M. (2024). Propofol-induced transient arginine vasopressin deficiency. Endocrinology, Diabetes and Metabolism Case Reports, 2024(4), 5 pages.
2024 Umapathysivam, M. M., Morgan, B., Inglis, J. M., Meyer, E., Liew, D., Thiruvenkatarajan, V., & Jesudason, D. (2024). SGLT2 Inhibitor-Associated Ketoacidosis vs Type 1 Diabetes-Associated Ketoacidosis. JAMA Network Open, 7(3), E242744.
Scopus5 Europe PMC32024 Jalleh, R. J., Phillips, L., Umapathysivam, M. M., Jones, K. L., Marathe, C. S., Watson, L. E., . . . Horowitz, M. (2024). Gastric emptying during and following resolution of moderate diabetic ketoacidosis in type 1 diabetes: a case series. BMJ Open Diabetes Research & Care, 12(2), e003854-1-e003854-4.
2024 Wittert, G., & Umapathysivam, M. M. (2024). Testosterone and the prevention of type 2 diabetes mellitus: therapeutic implications from recent trials. Current Opinion in Endocrinology, Diabetes and Obesity, 31(6), 243-248.
Scopus12024 Hayes, A. G., Stowasser, M., Umapathysivam, M. M., Falhammar, H., & Torpy, D. J. (2024). Approach to the Patient: Reninoma. Journal of Clinical Endocrinology and Metabolism, 109(2), e809-e816.
Scopus4 WoS1 Europe PMC42024 Umapathysivam, M. M., Gunton, J., Stranks, S. N., & Jesudason, D. (2024). Euglycemic Ketoacidosis in Two Patients Without Diabetes After Introduction of Sodium–Glucose Cotransporter 2 Inhibitor for Heart Failure With Reduced Ejection Fraction. Diabetes Care, 47(1), 140-143.
Scopus22 Europe PMC142024 Tan, S., Vuong, A., Kovoor, J., Gupta, A., Chan, W. O., Umapathysivam, M., . . . Bacchi, S. (2024). Beware of little expenses: Low-value endocrinological blood tests in geriatric medical inpatients. Australasian Journal on Ageing, 43(1), 211-214.
Scopus1 Europe PMC12023 Jalleh, R. J., Umapathysivam, M. M., Plummer, M. P., Deane, A., Jones, K. L., & Horowitz, M. (2023). Postprandial plasma GLP-1 levels are elevated in individuals with postprandial hypoglycaemia following Roux-en-Y gastric bypass – a systematic review. Reviews in Endocrine and Metabolic Disorders, 24(6), 1075-1088.
Scopus8 Europe PMC82023 Umapathysivam, M. M., Morgan, B., Bischoff, C., Hayes, A., Wilks, M., Stowasser, M., & Torpy, D. J. (2023). Intraprocedural cortisol testing improves adrenal vein cannulation success and diagnostic accuracy in assessment of primary aldosteronism, in a medium throughput centre. Journal of Human Hypertension, 37(9), 783-787.
Scopus8 WoS2 Europe PMC52023 Thiruvenkatarajan, V., Inglis, J. M., Meyer, E., Umapathysivam, M. M., Nanjappa, N., Van Wijk, R., & Jesudason, D. (2023). Peri-colonoscopy Implications of Sodium-Glucose Cotransporter-2 Inhibitor Therapy: A Mini-review of Available Evidence. Canadian Journal of Diabetes, 47(3), 287-291.
Scopus2 Europe PMC12023 Umapathysivam, M. M., Inglis, J. M., Morgan, B., Meyer, E., Thiruvenkatarajan, V., & Jesudason, D. (2023). Letter to the Editor: Response to Hamblin et al body mass index is inversely associated with capillary ketones at the time of colonoscopy: Implications for SGLT2i use. Clinical Endocrinology, 98(3), 449-451.
Scopus2 WoS1 Europe PMC12022 Umapathysivam, M., Grossmann, M., & Wittert, G. A. (2022). Effects of androgens on glucose metabolism. Best Practice and Research: Clinical Endocrinology and Metabolism, 36(5), 1-13.
Scopus8 WoS2 Europe PMC32022 Hayes, A. G., Umapathysivam, M. M., & Torpy, D. J. (2022). Accidental exposure to glimepiride from adulterated medication resulting in severe hypoglycaemia. Endocrinology, Diabetes and Metabolism Case Reports, 2022(1), 4 pages.
Scopus12021 Horowitz, M., Rayner, C. K., Marathe, C. S., Wu, T., Umapathysivam, M., & Jones, K. L. (2021). Response to Dahl et al: Oral semaglutide improves postprandial glucose and lipid metabolism, and delays gastric emptying, in subjects with type 2 diabetes. Diabetes, Obesity and Metabolism, 23(10), 2411-2413.
Scopus5 WoS2 Europe PMC32018 Thomsen, S. K., Raimondo, A., Hastoy, B., Sengupta, S., Dai, X. Q., Bautista, A., . . . Gloyn, A. L. (2018). Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells. Nature Genetics, 50(8), 1122-1131.
Scopus52 WoS41 Europe PMC502014 Umapathysivam, M., Lee, M., Jones, K., Annink, C., Cousins, C., Trahair, L., . . . Deane, A. (2014). Comparative effects of prolonged and intermittent stimulation of the glucagon- like peptide 1 receptor on gastric emptying and glycemia. Diabetes, 63(2), 785-790.
Scopus138 WoS95 Europe PMC982013 Lee, M., Fraser, J., Chapman, M., Sundararajan, K., Umapathysivam, M., Summers, M., . . . Deane, A. (2013). The effect of exogenous glucose-dependent insulinotropic polypeptide in combination with glucagon-like peptide-1 on glycemia in the critically ill. Diabetes Care, 36(10), 3333-3336.
Scopus16 WoS16 Europe PMC13 -
Conference Papers
Year Citation 2024 Araldi, E., Umapathysivam, M. M., Hastoy, B., Dawed, A. Y., Vatandaslar, H., Sengupta, S., . . . Gloyn, A. L. (2024). Type 2 diabetes risk alleles in peptidyl-glycine alpha-amidating monooxygenase influence GLP-1 levels and response to GLP-1 receptor agonists. In FEBS OPEN BIO Vol. 14 (pp. 467). WILEY. 2019 Sengupta, S., Bonnycastle, L. L., Hastoy, B., Grotz, A., Umapathysivam, M. M., Raimondo, A., . . . Gloyn, A. L. (2019). Investigating a Candidate Causal Allele in Type 2 Diabetes Susceptibility Gene PAM as a Cause of Neonatal Diabetes Mellitus. In DIABETES Vol. 68 (pp. 2 pages). CA, San Francisco: AMER DIABETES ASSOC.
DOI
2023 Do carriers of type 2 diabetes risk alleles in PAM have accelerated gastric emptying? Principal investigator. Diabetes Australia Project Grant. (Y24G-UMAM) $57,352.
2023 SGLT2i induced DKA RCT of fluid rate. Principal Investigator. Australian Diabetes Society/Astrazeneca Grant. $20,000
2022 Effect of subcutaneous (sc) semaglutide on gastric emptying measured using the 'gold standard' technique, scintigraphy, in type 2 diabetes (T2D). Associate Investigator. Diabetes Australia Project Grant. $70,000.
2021 Effect of rate of onset of hypoglycaemia on counter regulatory response in type 1 diabetes. Principal Investigator. Diabetes Australia Project Grant. (Y22G-UMAM) $67,000
2018 Diabetes physiology stream £5406 Principal Investigator. Oxford Biomedical Research Centre Pump Priming Grant (approx. $10,000)
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 Co-Supervisor Interactions between sleep, circadian rhythm, dysglycaemia and sex steroids Doctor of Philosophy Doctorate Full Time Mr Alebachew Fasil Ashagre
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