Dr Stephen Kidd
Stephen graduated from the University of Queensland (PhD - molecular microbiology) and then undertook postdoctoral work at the University of Birmingham (UK) with Prof Nigel Brown. He moved to the University of Adelaide in 2008 where he works on pathogenic bacteria. He has consistently worked on gene regulation in bacteria.
His current research is focussed on determining the molecular and transcriptional systems bacteria use to survive under prolonged periods of time with stress. What is particularly interesting is that within an anatomical niche and importantly, over time, bacteria generate a diversity of cell types and these enable survival. Identifying and characterising these adaptive cell types is important for understanding chronic and relapsing infectious diseases. His research investigates various pathogenic bacteria. Within different anatomical niches he is interested in numerous stresses the bacteria encounter and these include nutrient stress, changes in pH as well a direct chemical stress (such as oxidative stress) and the stress generated by antibiotics.
✓ Eligible to supervise Masters and PhD — email supervisor to discuss availability.
Our focus is to understand chronic and relapsing bacterial infections. We use various traditional microbiological techniques together with modern –omics approaches to determine the molecular systems that bacteria use to survive for prolonged periods of time under physical and chemical stresses. What is particularly interesting is that when infecting an anatomical niche, over a long time period, bacteria generate a diversity of cell types – it is these that enable survival against various antimicrobial processes.
By creating steady-state growth conditions we can enable the broader bacterial cell types which may have decreased fitness; to be studied – these include biofilm cells, persister cells and Small Colony Variants (SCVs). Identifying and characterising these adaptive cell types is important for understanding chronic and relapsing infectious diseases. Our research investigates various pathogenic bacteria, commensal bacteria that do switch to a virulent type and the combinations of bacteria.
Many bacterial species have a capacity to respond to antimicrobial processes and assaults by the production of any number of virulence factors (above; blue circles). Pathology that is due to bacterial infection is generally the result of the interaction between these factors and the host cells. There is also a very clear understanding that within a clonal population of bacterial cells there are a variety of cell types (phenotypic variants). This may include the Small Colony Variants (SCVs – above; pale green circles), persister cells (above; dark green circles) and biofilm cells (above; gold circles).
These cell types are quasi-dormant, they have limited expression of virulence factors and immune mediators and they have low metabolic activity and growth. There are inherently tolerant of antibiotics. They are very hard to clear from the site of infection and are the basis for chronic and relapsing infections.
Compounded with this is that often within the body there are pre-existing bacteria or other co-infecting pathogens. We have projects that study different bacterial species and their transition into an alternative lifestyle: such as Staphylococcus aureus, Moraxella catarrhalis, Haemophilus influenzae and Streptococcus pneumoninae.
We have used continuous culture techniques to follow the development of phenotypically diverse populations (as a mono-culture or within a community of bacterial species) and then to map the transcriptional, molecular and genetic events that define these changes in the population. This includes the transition to a biofilm and the dynamics of a multi-species biofilm. We are also interested in following the molecular genetics of the bacteria and the bacterial population as they adapt to their environment in laboratory scale evolution expierments.
CURRENT STUDENT PROJECTS:
We have Honours Projects each year within the theme of the molecular microbiology of pathogenic bacteria during their response to stresses. The projects involve traditional microbiology, molecular biology and modern –omics techniques as well as cell biology (using human tissue culture techniques). Projects are designed around both fundamental, training and achievable tasks alongside extended goals. These projects are designed within the context of the current, developing research within the laboratory. The work is essential research, with a focus to combine with the bigger projects and therefore for scientific publications. The exact nature of the work can be discussed and actual projects described in the month or so leading into the start of the Honours year.
Masters and PhD projects:
We welcome Masters or PhD students and can happily discuss the nature of such projects.
|2018||Deputy Director (Australian Centre for Antimicrobial Resistance Ecology, ACARE)||University of Adelaide, Adelaide|
|2017||Associate Dean (Student Life)||University of Adelaide, Adelaide|
|2013||Senior Lecturer||University of Adelaide|
|2008 - 2012||Lecturer||University of Adelaide|
|2012||Award||Faculty of Science Early Career Teaching Award||University of Adelaide||Australia||—|
|2009||Fellowship||Fellow of the Australian Society for Microbiology||ASM||Australia||—|
|2008||University of Queensland, Brisbane||Australia||Graduate Certificate (Higher Education)|
|1995 - 1998||University of Queensland||Australia||PhD|
|2016||Kyd, J., Krishnamurthy, A., & Kidd, S. P. (2016). Interactions and Mechanisms of Respiratory Tract Biofilms Involving Streptococcus Pneumoniae and Nontypeable Haemophilus Influenzae. In D. Dhanasekaran, & N. Thajuddin (Eds.), Microbial Biofilms - Importance and Applications (pp. 299-327). InTech.
|2011||Kidd, S. (2011). Novel Regulation in Response to Host-generated Stresses: The MerR Family of Regulators in Pathogenic Bacteria. In Stephen Kidd (Ed.), Stress Response in Pathogenic Bacteria (1 ed., pp. 93-114). United Kingdom: CABI Publishing.
I am Program Co-ordinator for the Bachelor of Science (Biotechnology).
I am Course Co-ordinator for Microbiology II
I teach into several other course.
I lead a Global Mobility Study tour to South Korea - Seoul-changing Biotechnology.
|Date||Role||Research Topic||Program||Degree Type||Student Load||Student Name|
|2018||Principal Supervisor||Induction of Stable Small Colony Variants in Staphylococcus Aureus||Doctor of Philosophy||Doctorate||Full Time||Mr James Lee|
|2017||Co-Supervisor||The role of persistent Lifestyles of Staphylococcus in ureus in bone infections||Doctor of Philosophy||Doctorate||Full Time||Mr Nicholas James Gunn|
|2017||Co-Supervisor||Parameters affecting biodigester performance||Doctor of Philosophy||Doctorate||Full Time||Mr Mathu Indren|
|2016||Co-Supervisor||Role of Shigelle Flexner Surface Molecules in Pathogenesis||Doctor of Philosophy||Doctorate||Full Time||Mr Jilong Qin|
|Date||Role||Research Topic||Program||Degree Type||Student Load||Student Name|
|2015 - 2015||Co-Supervisor||Characterisation of the Shigella flexneri O Antigen Polymerase Wzy||Doctor of Philosophy||Doctorate||Full Time||Ms Pratiti Nath|
|2013 - 2015||Co-Supervisor||Polarity and Secretion of Shigella flexneri IcsA: A Classical Autotransporter||Doctor of Philosophy||Doctorate||Full Time||Mr Matthew Thomas Doyle|
|2012 - 2016||Principal Supervisor||Haemophilus influenzae survival and biofilm formation in a complex physical, chemical and multispecies environment.||Doctor of Philosophy||Doctorate||Full Time||Alexandra Tikhomirova|
|2011 - 2015||Principal Supervisor||STAPHYLOCOCCUS AUREUS: STRESS RESPONSE AND ITS ROLES IN PATHOGENESIS||Doctor of Philosophy||Doctorate||Full Time||Miss Minh Giao Long Bui|
|2010 - 2016||Co-Supervisor||Proteomic Analysis of Enterococcus faecalis Cell Membrane Proteins under Alkaline Stress Conditions||Doctor of Philosophy||Doctorate||Part Time||APrf Peter Cathro|
|2009 - 2014||Principal Supervisor||Coupling Stress Responses and Growth Pathways in Haemophilus influenzae||Doctor of Philosophy||Doctorate||Full Time||Mr Changde Donald Jiang|
|2016 - ongoing||Chair||South Australian/NT ASM Branch committee||—||Australia|
|2015 - ongoing||Founder||StaphPath 2017 conference||—||Australia|
|2015 - ongoing||Member||School of Biological Sciences Teaching and Learning Committee||University of Adelaide||Australia|
|2015 - ongoing||Member||Masters of Biotechnology (Biomed. Sciences) Steering Committee||University of Adelaide||—|
|2012 - ongoing||Member||South Australian/NT ASM committee||ASM||Australia|
|2015 - ongoing||Member||Australian Society for Antimicrobials||Australia|
|2014 - ongoing||Member||American Society for Microbiology||United States|
|Date||Role||Editorial Board Name||Institution||Country|
|2014 - ongoing||Consulting Editor||Frontiers in cellular and infection microbiology||—||—|
|2016 - ongoing||Chair SA/NT branch ASM||ASM||Australia|