Professor Guy Ludbrook
Professor
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Professor Guy L Ludbrook PhD, MBBS, FANZCA
Professor Ludbrook is Professor of Anaesthesia at the University of Adelaide and Royal Adelaide Hospital.
Expertise:
Health systems, health services, health economics, anaesthesia, medical devices, clinical trials - phase 1 to phase 3,
He has published widely in the scientific literature with a particular focus on pharmacology and health system improvements.
He is Director of an early phase clinical trials unit, PARC Clinical Research, located within the Royal Adelaide Hospital.
He has been principle investigator on multiple clinical trials, both commercial and investigator-initiated, and sits on data safety monitoring boards for multiple international clinical trials.
He is increasingly involved in health services review to optimise value in healthcare, and in the design and the study of new systems of care.
Specialist Anaesthetist - MBBS FANZCA
Pharmacologist - PhD
Professor of Anaesthesia, Head of Acute Care Medicine, University of Adelaide
Director, PARC Clinical Research, Central Adelaide Local Health Network
Member, Advisory Committee on Medical Devices, Therapeutics Goods Administration
Education:
London Business School
Senior Executive Program, Business
2008 – 2008
London School of Economics
Masters in Health Economics, Policy and Management
2018-2021
Harvard Business School
Leading Health Care Organisations of Excellence
2009 – 2009
University of Adelaide
MBBS PhD, Anaesthesia, Pharmacology
1978 – 1993
Australian Institute of Company Directors
Graduate
2016 – 2016
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Appointments
Date Position Institution name 2000 - ongoing Professor of Anaesthesia University of Adelaide, Adelaide 2000 - ongoing Professor of Anaesthesia and Senior Staff Specialist Royal Adelaide Hospital, Adelaide -
Education
Date Institution name Country Title University Of Adelaide Australia MBBS University Of Adelaide Australia PhD Australian and New Zealand College of Anaesthetists, Melbourne Australia FANZCA -
Certifications
Date Title Institution name Country 2008 Senior Executive Program London Business School, London United Kingdom -
Research Interests
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Journals
Year Citation 2023 Ludbrook, G., Grocott, M. P. W., Heyman, K., Clarke-Errey, S., Royse, C., Sleigh, J., & Solomon, L. B. (2023). Outcomes of Postoperative Overnight High-Acuity Care in Medium-Risk Patients Undergoing Elective and Unplanned Noncardiac Surgery. JAMA Surgery, 158(7), 701-708.
Scopus4 WoS4 Europe PMC12023 Fitzgerald, N., Thiruvenkatarajan, V., Brown-Beresford, K., Liu, W. M., Gupta, D., Van Wijk, R. M., & Ludbrook, G. L. (2023). Incidence and predictors of airway obstruction during high-flow nasal oxygen assisted procedural sedation during gastrointestinal interventions: A prospective observational study. Journal of Clinical Anesthesia, 89, 1-2.
2023 Ludbrook, G. L., & Grocott, M. P. W. (2023). Estimating value in surgical and perioperative care: an essential component of quality. ANZ Journal of Surgery, 93(12), 2783-2785.
2023 Ludbrook, G., Grocott, M. P. W., & Clarke-Errey, S. (2023). Uncertain Definition of Medium Risk for Outcome Evaluation of Postoperative Overnight High-Acuity Care - Reply. JAMA Surgery, 158(12), 1352-1353.
2022 Thiruvenkatarajan, V., Dharmalingam, A., Arenas, G., Wahba, M., Liu, W. -M., Zaw, Y., . . . collaborators. (2022). Effect of high-flow vs. low-flow nasal plus mouthguard oxygen therapy on hypoxaemia during sedation: a multicentre randomised controlled trial.. Anaesthesia, 77(1), 46-53.
Scopus14 WoS12 Europe PMC92022 Ludbrook, G. L. (2022). The Hidden Pandemic: the Cost of Postoperative Complications. Current Anesthesiology Reports, 12(1), 9 pages.
Scopus16 WoS9 Europe PMC82022 Malycha, J., Redfern, O., Pimentel, M., Ludbrook, G., Young, D., & Watkinson, P. (2022). Evaluation of a digital system to predict unplanned admissions to the intensive care unit: A mixed-methods approach. Resuscitation Plus, 9, 1-7.
Scopus12022 Thiruvenkatarajan, V., Wong, D. T., van Wijk, R., & Ludbrook, G. L. (2022). Comment on: “Efficacy of high flow nasal oxygenation against hypoxemia in sedated patients receiving gastrointestinal endoscopic procedures: A systematic review and meta-analysis”. Journal of Clinical Anesthesia, 78, 110689.
2022 Ludbrook, G. L., & Peden, C. J. (2022). Improving safety and outcomes in perioperative care: does implementation matter?. British Journal of Anaesthesia, 128(5), 747-751.
Scopus1 WoS1 Europe PMC12022 Kadam, V. R., Ludbrook, G. L., Hewett, P., & Westley, I. (2022). Plasma ropivacaine levels after ultrasound-guided erector spinae plane block and wound infiltration in laparoscopic colonic surgery - An observational study. Indian Journal of Anaesthesia, 66(3), 231-232.
Scopus1 WoS12022 Thiruvenkatarajan, V., Sekhar, V., Wong, D. T., Currie, J., van Wijk, R., & Ludbrook, G. L. (2022). Effect of high-flow nasal oxygen on hypoxaemia during procedural sedation: a systematic review and meta-analysis.. Anaesthesia, 78(1), 12 pages.
Scopus9 WoS7 Europe PMC42022 Malycha, J., Andersen, C., Redfern, O. C., Peake, S., Subbe, C., Dykes, L., . . . Jones, D. (2022). Protocol describing a systematic review and mixed methods consensus process to define the deteriorated ward patient. . BMJ open, 12(9), e057614.
2021 Ludbrook, G., Li, F., Sleigh, J., & Liang, Y. (2021). Retraction: Assessments of Onset and Duration of Drug Effects and Pharmacokinetics by Dose Level of HSK3486, a New Sedative-Hypnotic Agent, in Healthy Female/Male Subjects: A Phase I Multiarm Randomized Controlled Clinical Trial [Retracted (Anesthesia and analgesia (2021) 133 1 (e16)). Anesthesia and analgesia.
Scopus4 Europe PMC32021 Ludbrook, G. L., & Leaman, E. (2021). Cost-Effectiveness in Perioperative Care: Application of Markov Modeling to Pathways of Perioperative Care. Value in Health, 25(2), 215-221.
Scopus2 WoS2 Europe PMC12021 Rao Kadam, V., Ludbrook, G., van Wijk, R. M., Hewett, P., Thiruvenkatarajan, V., Edwards, S., . . . Adhikary, S. (2021). A comparison of ultrasound guided bilateral single injection shot Erector Spinae Plane blocks versus wound infiltration for post-operative analgesia in laparoscopic assisted colonic surgery- a prospective randomised study. BMC Anesthesiology, 21(1), 1-7.
Scopus5 WoS1 Europe PMC22021 Ludbrook, G., Lloyd, C., Story, D., Maddern, G., Riedel, B., Richardson, I., . . . Edwards, S. (2021). The effect of advanced recovery room care on postoperative outcomes in moderate-risk surgical patients: a multicentre feasibility study. Anaesthesia, 76(4), 480-488.
Scopus15 WoS10 Europe PMC72021 Ludbrook, G., Riedel, B., Martin, D., & Williams, H. (2021). Improving outcomes after surgery: a roadmap for delivering the value proposition in perioperative care. ANZ Journal of Surgery, 91(3), 225-228.
Scopus5 WoS5 Europe PMC32020 Malycha, J., Murphy, D., Barker, G., Ludbrook, G., Young, J. D., & Watkinson, P. J. (2020). Using real-time location devices (RTLD) to quantify off-unit adult intensive care registrar workload: a 1-year tertiary NHS hospital prospective observational study. Journal of Clinical Monitoring and Computing, 34(4), 805-809.
2020 Lloyd, C., Proctor, L., Au, M., Story, D., Edwards, S., & Ludbrook, G. (2020). Incidence of early major adverse events after surgery in moderate-risk patients: early postoperative adverse events.. British journal of anaesthesia, 124(1), e9-e10.
Scopus7 Europe PMC42020 Rao Kadam, V., Ludbrook, G., van Wijk, R., Hewett, P., Thiruvenkatarajan, V., Moran, J., & Williams, P. (2020). Ultrasound-guided transmuscular quadratus lumborum block catheter technique: a reply. Anaesthesia, 75(3), 414-415.
Scopus1 WoS1 Europe PMC12020 Lloyd, C., Ludbrook, G., Story, D., & Maddern, G. (2020). 'Organisation of delivery of care in operating suite recovery rooms within 48 hours postoperatively and patient outcomes after adult non-cardiac surgery: a systematic review'. BMJ Open, 10(3), e027262-1-e027262-10.
Scopus8 WoS8 Europe PMC32020 Tran, A., Thiruvenkatarajan, V., Wahba, M., Currie, J., Rajbhoj, A., van Wijk, R., . . . Ludbrook, G. (2020). LMA® Gastro™ Airway for endoscopic retrograde cholangiopancreatography: a retrospective observational analysis.. BMC anesthesiology, 20(1), 113.
Scopus18 WoS14 Europe PMC102020 Thiruvenkatarajan, V., Dharmalingam, A., Arenas, G., Wahba, M., Steiner, R., Kadam, V. R., . . . Ludbrook, G. (2020). High-flow nasal cannula versus standard oxygen therapy assisting sedation during endoscopic retrograde cholangiopancreatography in high risk cases (OTHER): study protocol of a randomised multicentric trial.. Trials, 21(1), 444.
Scopus7 WoS6 Europe PMC52019 Kadam, V. R., Van Wijk, R. M., Ludbrook, G. L., & Thiruvenkatarajan, V. (2019). Anatomical and ultrasound description of two transmuscular quadratus lumborum block approaches at L2 level and their application in abdominal surgery. Anaesthesia and Intensive Care, 47(2), 141-145.
Scopus2 WoS2 Europe PMC12019 Malycha, J., Bonnici, T., Clifton, D. A., Ludbrook, G., Young, J. D., & Watkinson, P. J. (2019). Patient centred variables with univariate associations with unplanned ICU admission: a systematic review. BMC Medical Informatics and Decision Making, 19(1), 98-1-98-9.
Scopus9 WoS7 Europe PMC72019 Malycha, J., Farajidavar, N., Pimentel, M. A. F., Redfern, O., Clifton, D. A., Tarassenko, L., . . . Watkinson, P. J. (2019). The effect of fractional inspired oxygen concentration on early warning score performance: A database analysis. Resuscitation, 139, 192-199.
Scopus14 WoS10 Europe PMC122019 Rao Kadam, V., Ludbrook, G., van Wijk, R. M., Hewett, P. J., Moran, J. L., Thiruvenkatarajan, V., & Williams, P. J. (2019). Comparison of ultrasound-guided transmuscular quadratus lumborum block catheter technique with surgical pre-peritoneal catheter for postoperative analgesia in abdominal surgery: a randomised controlled trial. Anaesthesia, 74(11), 8 pages.
Scopus13 WoS14 Europe PMC62019 Malycha, J., Redfern, O. C., Ludbrook, G., Young, D., & Watkinson, P. J. (2019). Testing a digital system that ranks the risk of unplanned intensive care unit admission in all ward patients: Protocol for a prospective observational cohort study. BMJ Open, 9(9), 4 pages.
Scopus6 WoS4 Europe PMC42019 Grocott, M. P. W., & Ludbrook, G. L. (2019). Economic evaluation of prehabilitation: a true return on investment?. British Journal of Anaesthesia, 123(6), 710-712.
Scopus10 WoS6 Europe PMC32019 Ludbrook, G. L., & Walsh, R. M. (2019). Impact of age on the future burden of postoperative complications in Australia.. Anaesthesia and intensive care, 47(5), 480-481.
Scopus5 WoS3 Europe PMC22018 Jones, C. R., McCulloch, G. A. J., Ludbrook, G., Babidge, W. J., & Maddern, G. J. (2018). Deaths in incorrectly identified low-surgical-risk patients. World Journal of Surgery, 42(7), 1997-2000.
Scopus4 WoS42018 Ludbrook, G. (2018). Hidden pandemic of postoperative complications—time to turn our focus to health systems analysis. British Journal of Anaesthesia, 121(6), 1190-1192.
Scopus11 Europe PMC52017 Upton, H., Ludbrook, G., Wing, A., & Sleigh, J. (2017). Intraoperative "analgesia nociception index"-guided fentanyl administration during sevoflurane anesthesia in lumbar discectomy and laminectomy: A randomized clinical trial. Anesthesia and Analgesia, 125(1), 81-90.
Scopus67 WoS53 Europe PMC292017 Petersen Tym, M., Ludbrook, G., Flabouris, A., Seglenieks, R., & Painter, T. (2017). Developing models to predict early postoperative patient deterioration and adverse events. ANZ Journal of Surgery, 87(6), 457-461.
Scopus17 WoS13 Europe PMC62017 Ludbrook, G. L., & Goldsman, A. G. (2017). Coordinated perioperative care - A high value proposition?. British Journal of Anaesthesia, 118(1), 3-5.
Scopus2 WoS2 Europe PMC22016 Ha, T., van Renen, R., Ludbrook, G., & Wormald, P. (2016). The effect of blood pressure and cardiac output on the quality of the surgical field and middle cerebral artery blood flow during endoscopic sinus surgery. International Forum of Allergy and Rhinology, 6(7), 701-709.
Scopus20 WoS22 Europe PMC82016 Maiden, M., Chapman, M., Torpy, D., Kuchel, T., Clarke, I., Nash, C., . . . Ludbrook, G. (2016). Triiodothyronine administration in a model of septic shock: A randomized blinded placebo-controlled trial. Critical Care Medicine, 44(6), 1153-1160.
Scopus5 WoS5 Europe PMC32015 Ludbrook, G., Seglenieks, R., Osborn, S., & Grant, C. (2015). A call centre and extended checklist for pre-screening elective surgical patients - a pilot study. BMC Anesthesiology, 15(1), 77-1-77-6.
Scopus12 WoS10 Europe PMC52015 Ford, N., Ludbrook, G., & Galletly, C. (2015). Benzodiazepines may reduce the effectiveness of ketamine in the treatment of depression. Australian and New Zealand Journal of Psychiatry, 49(12), 1227.
Scopus20 WoS15 Europe PMC102014 Painter, T., & Ludbrook, G. (2014). Predicting patients at risk of early postoperative adverse. Anaesthesia and Intensive Care, 42(5), 649-656.
Scopus18 WoS15 Europe PMC82014 Dooney, N., Sundararajan, K., Ramkumar, T., Somogyi, A., Upton, R., Ong, J., . . . Ludbrook, G. (2014). Pharmacokinetics of tramadol after subcutaneous administration in a critically ill population and in a healthy cohort. BMC Anesthesiology, 14(1), 33-1-33-8.
Scopus6 WoS6 Europe PMC42014 Ha, T., van Renen, R., Ludbrook, G., Valentine, R., Ou, J., & Wormald, P. (2014). The relationship between hypotension, cerebral flow, and the surgical field during endoscopic sinus surgery. The Laryngoscope, 124(10), 2224-2230.
Scopus25 WoS19 Europe PMC102014 Painter, T., & Ludbrook, G. L. (2014). Reply from the authors. British Journal of Anaesthesia, 112(1), 172.
2013 Sutherland, J., & Ludbrook, G. (2013). Pre-admission processes and opportunities for improvement. Anaesthesia and Intensive Care, 41(3), 427-428.
Scopus12013 Painter, T., & Ludbrook, G. L. (2013). Reducing system errors in the preoperative assessment process. British Journal of Anaesthesia, 110(6), 1060-1061.
Scopus5 WoS7 Europe PMC42013 Ludbrook, G., O'Loughlin, E., Grant, C., & Corcoran, T. (2013). The relationship between patient data and pooled clinical management decisions. Anaesthesia and Intensive Care, 41(1), 57-65.
Scopus3 WoS3 Europe PMC32013 Freeman, B., Ludbrook, G., Hall, S., Cousins, M., Mitchell, B., Jaros, M., . . . Gorman, J. (2013). Randomized, double-blind, placebo-controlled, trial of transforaminal epidural etanercept for the treatment of symptomatic lumbar disc herniation. Spine, 38(23), 1986-1994.
Scopus58 WoS46 Europe PMC322012 Viscusi, E., Candiotti, K., Onel, E., Morren, M., & Ludbrook, G. (2012). The pharmacokinetics and pharmacodynamics of liposome bupivacaine administered via a single epidural injection to healthy volunteers. Regional Anesthesia and Pain Medicine, 37(6), 616-622.
Scopus61 WoS49 Europe PMC292012 Krishnamurthy, R., Upton, R., Fajumi, A., Lai, S., Charlton, C., Ousley, R., . . . Ludbrook, G. (2012). Pharmacokinetics of oxycodone after subcutaneous administration in a critically ill population compared with a healthy cohort. Anaesthesia and Intensive Care, 40(2), 269-274.
Scopus9 WoS6 Europe PMC32012 Grant, C., Ludbrook, G., O'Loughlin, E., & Corcoran, T. (2012). An analysis of computer-assisted pre-screening prior to elective surgery. Anaesthesia and Intensive Care, 40(2), 297-304.
Scopus17 WoS18 Europe PMC112012 Grant, C., Ludbrook, G. L., O'Loughlin, E. J., & Corcoran, T. B. (2012). An analysis of computer-assisted pre-screening prior to elective surgery (Anaesth Intensive Care (2012) 40, (207-394)). Anaesthesia and Intensive Care, 40(3), 530. 2011 Leslie, K., Wu, C. Y. X., Bjorksten, A. R., Williams, D. L., Ludbrook, G., & Williamson, E. (2011). Cardiac output and propofol concentrations in prone surgical patients. Anaesthesia and Intensive Care, 39(5), 868-874.
Scopus32010 Ho, J., Chapman, M., O'Connor, S., Lam, S., Edwards, J., Ludbrook, G., . . . Torpy, D. (2010). Characteristics of plasma NOx levels in severe sepsis: High interindividual variability and correlation with illness severity, but lack of correlation with cortisol levels. Clinical Endocrinology, 73(3), 413-420.
Scopus13 WoS11 Europe PMC72010 Capper, S., Loo, S., Geue, J., Upton, R., Ong, J., Macintyre, P., & Ludbrook, G. (2010). Pharmacokinetics of fentanyl after subcutaneous administration in volunteers. European Journal of Anaesthesiology, 27(3), 241-246.
Scopus21 WoS17 Europe PMC72009 Ludbrook, G., & Maddern, G. (2009). Doctor displacement: a political agenda or a health care imperative?. Medical Journal of Australia, 190(7), 396-397.
Scopus1 WoS12008 Grant, C., Ludbrook, G., Hampson, E., Semenov, R., & Willis, R. (2008). Adverse physiological events under anaesthesia and sedation: a pilot audit of electronic patient records. Anaesthesia and Intensive Care, 36(2), 222-229.
Scopus20 WoS13 Europe PMC102008 Upton, R., Rasmussen, M., Grant, C., Martinez, A., Cold, G., & Ludbrook, G. (2008). Pharmacokinetics and pharmacodynamics of indomethacin: Effects on cerebral blood flow in anaesthetized sheep. Clinical and Experimental Pharmacology and Physiology, 35(3), 317-323.
Scopus10 WoS10 Europe PMC82007 Voss, L., Ludbrook, G., Grant, C., Upton, R., & Sleigh, J. (2007). A comparison of pharmacokinetic/pharmacodynamic versus mass-balance measurement of brain concentrations of intravenous anesthetics in sheep. Anesthesia and Analgesia, 104(6), 1440-1446.
Scopus16 WoS11 Europe PMC62007 Ludbrook, G., & Sutherland, P. (2007). Erroneous pulse oximetry readings during robotic prostatectomy. Anaesthesia and Intensive Care, 35(1), 144-145.
Scopus3 Europe PMC22007 Alkhazrajy, W., Macintyre, P., Upton, R., Ong, J., & Ludbrook, G. (2007). An audit of the safety and effectiveness of an alfentanil: morphine mixture in the postanaesthesia care unit. Acute Pain, 9(1), 13-19.
Scopus22006 Rasmussen, M., Upton, R., Grant, C., Martinez, A., Cold, G., & Ludbrook, G. (2006). The effects of indomethacin on intracranial pressure and cerebral hemodynamics during isoflurane or propofol anesthesia in sheep with intracranial hypertension. Anesthesia and Analgesia, 102(6), 1823-1829.
Scopus4 WoS2 Europe PMC22006 Voss, L., Ludbrook, G., Grant, C., Sleigh, J., & Barnard, J. (2006). Cerebral cortical effects of desflurane in sheep: comparison with isoflurane, sevoflurane and enflurane. Acta Anaesthesiologica Scandinavica, 50(3), 313-319.
Scopus28 WoS22 Europe PMC192006 Kalairajah, Y., Cossey, A., Verrall, G., Ludbrook, G., & Spriggins, A. (2006). Are systemic emboli reduced in computer-assisted knee surgery? A prospective, randomised, clinical trial. Journal of Bone and Joint Surgery-British Volume, 88B(2), 198-202.
Scopus123 Europe PMC642006 Kalairajah, Y., Cossey, A. J., Verrall, G. M., Ludbrook, G., & Spriggins, A. J. (2006). Erratum: Are systemic emboli reduced in computer-assisted knee surgery? A prospective, randomised, clinical trial (Journal of Boe and Joint Surgery - Series B (2006) vol 88-B (198-202)). Journal of Bone and Joint Surgery - Series B, 88(10), 1407. 2005 Upton, R., & Ludbrook, G. (2005). A physiologically based, recirculatory model of the kinetics and dynamics of propofol in man. Anesthesiology, 103(2), 344-352.
Scopus59 WoS48 Europe PMC372005 Westhorpe, R., Ludbrook, G., & Helps, S. (2005). Crisis management during anaesthesia: bronchospasm. Quality and Safety in Health Care, 14(3), e7/WWW 1-WWW 6.
Scopus49 WoS33 Europe PMC262005 Szekely, S., Runciman, W., Webb, R., & Ludbrook, G. (2005). Crisis management during anaesthesia: desaturation. Quality and Safety in Health Care, 14(3), e6/WWW 1-WWW 6.
Scopus21 WoS9 Europe PMC62005 Ludbrook, G., Webb, R., Currie, M., & Watterson, L. (2005). Crisis management during anaesthesia: myocardial ischaemia and infarction. Quality and Safety in Health Care, 14(3), e13/WWW 1-WWW 4.
Scopus6 WoS6 Europe PMC22005 Upton, R., & Ludbrook, G. (2005). Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of drugs – method development and application to magnesium in sheep. BMC Pharmacology, 5(1), 5-1-5-22.
Scopus23 Europe PMC132004 Upton, R., Grant, C., Martinez, A., & Ludbrook, G. (2004). Recirculatory model of fentanyl disposition with the brain as the target organ. British Journal of Anaesthesia, 93(5), 687-697.
Scopus14 WoS13 Europe PMC112004 Sleigh, J., Steyn-Ross, D., Steyn-Ross, M., Grant, C., & Ludbrook, G. (2004). Cortical entropy changes with general anaesthesia: theory and experiment. Physiological Measurement, 25(4), 921-934.
Scopus85 WoS82 Europe PMC412003 Ludbrook, G., & Upton, R. (2003). Pharmacokinetic drug interaction between propofol and remifentanil?. Anesthesia and Analgesia, 97(3), 924-925.
Scopus11 WoS10 Europe PMC72003 Upton, R., Ludbrook, G., Martinez, A., Grant, C., & Milne, R. (2003). Cerebral and lung kinetics of morphine in conscious sheep after short intravenous infusions. British Journal of Anaesthesia, 90(6), 750-758.
Scopus16 WoS16 Europe PMC112002 Myburgh, J., Upton, R., Ludbrook, G., Martinez, A., & Grant, C. (2002). Cerebrovascular carbon dioxide reactivity in sheep: Effect of propofol or isoflurane anaesthesia. Anaesthesia and Intensive Care, 30(4), 413-421.
Scopus13 WoS11 Europe PMC112002 Ludbrook, G., & Upton, R. (2002). Determinants of drug onset. Current Opinion in Anaesthesiology, 15(4), 409-414.
Scopus5 Europe PMC22002 Ludbrook, G., Visco, E., & Lam, A. (2002). Propofol: relation between brain concentrations, electroencephalogram, middle cerebral artery blood flow velocity, and cerebral oxygen extraction during induction of anesthesia. Anesthesiology, 97(6), 1363-1370.
Scopus81 WoS67 Europe PMC572001 Zheng, D., Upton, R., Ludbrook, G., & Martinez, A. (2001). Acute cardiovascular effects of magnesium and their relationship to systemic and myocardial magnesium concentrations after short infusion in awake sheep. Journal of Pharmacology and Experimental Therapeutics, 297(3), 1176-1183.
Scopus12 WoS9 Europe PMC102001 Upton, R., Ludbrook, G., Grant, C., & Martinez, A. (2001). In vivo cerebral pharmacokinetics and pharmacodynamics of diazepam and midazolam after short intravenous infusion administration in sheep. Journal of Pharmacokinetics and Pharmacodynamics, 28(2), 129-153.
Scopus7 WoS6 Europe PMC52001 Upton, R., Ludbrook, G., & Grant, C. (2001). The cerebral and systemic kinetics of thiopentone and propofol in halothane anaesthetized sheep. Anaesthesia and Intensive Care, 29(2), 117-123.
Scopus5 WoS4 Europe PMC22001 Ludbrook, G., Macintyre, P., Douglas, H., Ong, J., & Upton, R. (2001). A mixture of alfentanil and morphine for rapid postoperative loading with opioid: theoretical basis and initial clinical investigation. Anaesthesia, 56(8), 1-7.
Scopus8 WoS4 Europe PMC32001 Ludbrook, G., Macintyre, P., Douglas, H., Ong, L., & Upton, R. (2001). A mixture of alfentanil and morphine for rapid postoperative loading with opioid: theoretical basis and initial clinical investigation.. Anaesthesia, 56(8), 739-744.
2000 Upton, R., Ludbrook, G., Grant, C., & Doolette, D. (2000). The effect of altered cerebral blood flow on the cerebral kinetics of thiopental and propofol in sheep. Anesthesiology, 93(4), 1085-1094.
Scopus34 WoS33 Europe PMC251999 Bessell, J., Ludbrook, G., Millard, S., Baxter, P., Ubhi, S., & Maddern, G. (1999). Humidified gas prevents hypothermia induced by laparoscopic insufflation. A randomized controlled study in a pig model. Surgical Endoscopy, 13(2), 101-105.
Scopus43 WoS46 Europe PMC361999 Ludbrook, G. L., James, M. F. M., & Upton, R. N. (1999). The effect of magnesium sulfate on cerebral blood flow velocity, cardiovascular variables, and arterial carbon dioxide tension in awake sheep. Journal of Neurosurgical Anesthesiology, 11(2), 96-101.
Scopus19 WoS13 Europe PMC71999 Upton, R. N., & Ludbrook, G. L. (1999). A model of the kinetics and dynamics of induction of anaesthesia in sheep: Variable estimation for thiopental and comparison with propofol. British Journal of Anaesthesia, 82(6), 890-899.
Scopus41 WoS40 Europe PMC271999 Upton, R., Ludbrook, G., Grant, C., & Martinez, A. (1999). Cardiac output is a determinant of the initial concentrations of Propofol after short-infusion administration. Anesthesia and Analgesia, 89(3), 545-552.
Scopus124 WoS111 Europe PMC831999 Ludbrook, G., Upton, R., Grant, C., & Martinez, A. (1999). Prolonged dysequilibrium between blood and brain concentrations of propofol during infusions in sheep. Acta Anaesthesiologica Scandinavica, 43(2), 206-211.
Scopus13 WoS12 Europe PMC91999 Ludbrook, G. L., Upton, R. N., Grant, C., & Martinez, A. (1999). A compartmental analysis of the pharmacokinetics of propofol in sheep. Journal of Pharmacokinetics and Biopharmaceutics, 27(3), 329-338.
Scopus13 WoS13 Europe PMC91999 Parsons, T. J., Upton, R. N., Martinez, A. M., & Ludbrook, G. L. (1999). No loss of undiluted propofol by sorption into administration systems. Pharmacy and Pharmacology Communications, 5(6), 377-381.
1998 Zheng, D., Upton, R., Martinez, A., Grant, C., & Ludbrook, G. (1998). The influence of the bolus injection rate of propofol on its cardiovascular effects and peak blood concentrations in sheep. Anesthesia and Analgesia, 86(5), 1109-1115.
Scopus31 WoS29 Europe PMC161998 Ludbrook, G., Upton, R., Grant, C., & Martinez, A. (1998). The effect of rate of administration on brain concentrations of propofol in sheep. Anesthesia and Analgesia, 86(6), 1301-1306.
Scopus29 WoS30 Europe PMC161997 Upton, R., Ludbrook, G., Gray, E., & Grant, C. (1997). The Cerebral Pharmacokinetics of Meperidine and Alfentanil in Conscious Sheep. Anesthesiology, 86(6), 1317-1325.
Scopus24 WoS23 Europe PMC191997 Huang, Y., Upton, R., Gray, E., Grant, C., Zheng, D., & Ludbrook, G. (1997). The effects of short intravenous infusions of thiopentone on myocardial function, blood flow and oxygen consumption in sheep. Anaesthesia and Intensive Care, 25(6), 627-633.
Scopus7 WoS5 Europe PMC41997 Ludbrook, G. L., Hitchcock, M., & Upton, R. N. (1997). The difficult airway: Propofol infusion as an alternative to gaseous induction. Anaesthesia and Intensive Care, 25(1), 71-73.
Scopus8 WoS8 Europe PMC41997 Ludbrook, G. L., & Upton, R. N. (1997). A physiological model of induction of anaesthesia with propofol in sheep. 2. Model analysis and implications for dose requirements. British Journal of Anaesthesia, 79(4), 505-513.
Scopus63 WoS55 Europe PMC421997 Upton, R. N., & Ludbrook, G. L. (1997). A physiological model of induction of anaesthesia with propofol in sheep. 1. Structure and estimation of variables. British Journal of Anaesthesia, 79(4), 497-504.
Scopus62 WoS56 Europe PMC401997 Ball, D. R., & Ludbrook, G. (1997). Propofol infusion for the difficult airway (multiple letters) [1]. Anaesthesia and Intensive Care, 25(5), 580-581.
Scopus3 Europe PMC21996 Ludbrook, G., Upton, R., Grant, C., & Gray, E. (1996). Cerebral effects of propofol following bolus administration in sheep. Anaesthesia and Intensive Care, 24(1), 26-31.
Scopus19 WoS15 Europe PMC81996 Ludbrook, G., Upton, R., Grant, C., & Gray, E. (1996). Brain and blood concentrations of propofol after rapid intravenous injection in sheep, and their relationships to cerebral effects. Anaesthesia and Intensive Care, 24(4), 445-452.
Scopus51 WoS49 Europe PMC301996 Upton, R. N., Huang, Y. F., Grant, C., Gray, E. C., & Ludbrook, G. L. (1996). Myocardial pharmacokinetics of thiopental in sheep after short-term administration: Relationship to thiopental-induced reductions in myocardial contractility. Journal of Pharmaceutical Sciences, 85(8), 863-867.
Scopus13 WoS13 Europe PMC91996 Mather, L., Upton, R., Huang, J., Ludbrook, G., Gray, E., & Grant, C. (1996). The systemic and cerebral kinetics of thiopental in sheep: enantiomeric analysis. Journal of Pharmacology and Experimental Therapeutics, 279(1), 291-297.
Scopus18 WoS16 Europe PMC91996 Upton, R., Ludbrook, G., Grant, C., & Gray, E. (1996). In vivo relationships between the cerebral pharmacokinetics and pharmacodynamics of thiopentone in sheep after short-term administration. Journal of Pharmacokinetics and Biopharmaceutics, 24(1), 1-18.
Scopus17 WoS16 Europe PMC101995 Ludbrook, G., Grant, C., Upton, R., & Penhall, C. (1995). A method for frequent measurement of sedation and analgesia in sheep using the response to a ramped electrical stimulus. Journal of Pharmacological and Toxicological Methods, 33(1), 17-22.
Scopus27 WoS23 Europe PMC181994 Bessell, J. R., Maddern, G. J., Manncke, K., Ludbrook, G., & Jamieson, G. G. (1994). Combined thoracoscopic and laparoscopic oesophagectomy and oesophagogastric reconstruction.. Endoscopic surgery and allied technologies, 2(1), 32-36.
Scopus15 Europe PMC21994 Upton, R., Grant, C., & Ludbrook, G. (1994). An ultrasonic Doppler venous outflow method for the continuous measurement of cerebral blood flow in conscious sheep. Journal of Cerebral Blood Flow and Metabolism, 14(4), 680-688.
Scopus53 WoS50 Europe PMC391993 Singleton, R. J., Ludbrook, G. L., Webb, R. K., & Fox, M. A. L. (1993). Physical injuries and environmental safety in anaesthesia: An analysis of 2000 incident reports. Anaesthesia and Intensive Care, 21(5), 659-663.
Scopus19 WoS14 Europe PMC81993 Klepper, I. D., Webb, R. K., Van der Walt, J. H., Ludbrook, G. L., & Cockings, J. (1993). The stethoscope: Applications and limitations - An analysis of 2000 incident reports. Anaesthesia and Intensive Care, 21(5), 575-578.
Scopus25 WoS23 Europe PMC111993 Singleton, R. J., Webb, R. K., Ludbrook, G. L., & Fox, M. A. L. (1993). Problems associated with vascular access: An analysis of 200 incident reports. Anaesthesia and Intensive Care, 21(5), 664-669.
Scopus28 WoS16 Europe PMC151993 Ludbrook, G. L., Webb, R. K., Fox, M. A., & Singleton, R. J. (1993). Problems before induction of anaesthesia: An analysis of 2000 incident reports. Anaesthesia and Intensive Care, 21(5), 593-595.
Scopus11 WoS10 Europe PMC21993 Fox, M. A. L., Webb, R. K., Singleton, R., Ludbrook, G., & Runciman, W. B. (1993). Problems with regional anaesthesia: An analysis of 2000 incident reports. Anaesthesia and Intensive Care, 21(5), 646-649.
Scopus38 WoS331993 Ludbrook, G. L., Russell, W. J., Webb, R. K., Klepper, I. D., & Currie, M. (1993). The electrocardiograph: Applications and limitations - An analysis of 2000 incident reports. Anaesthesia and Intensive Care, 21(5), 558-564.
Scopus13 WoS14 Europe PMC61992 Ludbrook, G. L., Helps, S. C., Gorman, D. F., Reilly, P. L., North, J. B., & Grant, C. (1992). The relative effects of hypoxic hypoxia and carbon monoxide on brain function in rabbits. Toxicology, 75(1), 71-80.
Scopus14 WoS13 Europe PMC71992 Ludbrook, G. L., Helps, S. C., & German, D. F. (1992). Cerebral blood flow response to increases in arterial CO<inf>2</inf> tension during alfentanil anesthesia in the rabbit. Journal of Cerebral Blood Flow and Metabolism, 12(3), 529-532.
Scopus10 WoS10 Europe PMC7 -
Book Chapters
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Conference Papers
Year Citation 2005 Stone, C., Humberstone, A. J., Gard'ner, K., Evans, A., Shaw, D., & Ludbrook, G. L. (2005). Steady-state pharmacokinetics of fentanyl after administration of a novel non-occlusive transdermal system.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 23 (pp. 778S). Orlando, FL: AMER SOC CLINICAL ONCOLOGY. -
Conference Items
Year Citation 2013 Maiden, M. J., Chapman, M. J., Torpy, D., Kuchel, T. R., Clarke, I., Nash, C. H., & Ludbrook, G. L. (2013). Tri-Iodothyronine (t3) Replacement In An Ovine Model Of Septic Shock. Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. -
Report for External Bodies
Year Citation 2002 Merlin, T. L., Hodgkinson, B., Macintyre, P., Ludbrook, G., & Hiller, J. E. (2002). Institutional approaches to pain assessment and management (008PAI): A systematic literature review. Melbourne, VIC: National Institute of Clinical Studies. -
Original Creative Works
Year Citation 2010 Authors: Jones J. Title: Responses. Description: Type of work : Poetry Extent : 1 p.. Extent: 1 p..
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 Co-Supervisor Effectiveness and safety of enhanced postoperative care units for non-cardiac surgery Master of Philosophy (Clinical Science) Master Full Time Dr Liem Tran 2021 Principal Supervisor Improving the safety of sedation strategies during advanced gastrointestinal endoscopic interventions such as Endoscopic Retrograde Cholangiopancreatography Evaluation of high flow nasal oxygenation on preoxygenation parameters during airway management for general anaesthesia procedures Doctor of Philosophy Doctorate Part Time APrf Venkatesan Thiruvenkatarajan -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 - 2023 Principal Supervisor New Regional Anaesthesia Fascial Blocks: Trans-muscular Quadratus Lumborum Block and Erector Spinae Block in Postoperative Pain Management in Colonic Surgery Doctor of Philosophy Doctorate Part Time Dr Vasanth Rao Kadam 2018 - 2020 Principal Supervisor The Effect of Advanced Recovery Room Care on Postoperative Outcomes in Medium Risk Surgical Patients Master of Clinical Science Master Part Time Dr Courtney Ellen Lloyd 2017 - 2022 Principal Supervisor Predicting Clinical Deterioration Doctor of Philosophy Doctorate Part Time Dr James Lewis Malycha 2012 - 2020 Co-Supervisor HYPERBARIC OXYGEN AND INSULIN SENSITIVITY Doctor of Philosophy Doctorate Part Time Dr David Wilkinson 2012 - 2017 Co-Supervisor Strategies for Controlling Bleeding and Healing During and After Sinus Surgery Doctor of Philosophy Doctorate Full Time Dr Thanh Ngoc Ha 2010 - 2015 Principal Supervisor Tri-iodothyronine (T3) Therapy in a Pre-Clinical Model of Septic Shock Doctor of Philosophy Doctorate Full Time Dr Matthew Jerome Maiden 2008 - 2008 Other Medically Staffed, Out of Hospital Critical Care Patient Transport (Retrieval) Services: Performance, Incidents and Patient Outcomes Doctor of Medicine Doctorate Full Time APrf Athanasios Flabouris
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