Dr Elizabeth Kuczek
Research Manager
Adelaide Medical School
Faculty of Health and Medical Sciences
Dr Kuczek completed her PhD at the University of Adelaide, and undertook postdoctoral research in molecular immunology (signal transduction and transcriptional regulation of cytokines and T cell surface receptors) at the Institute of Medical and Veterinary Science (Adelaide), the University of California, San Francisco (UCSF) and the Gladstone Institute for Virology and Immunology, San Francisco.
Outside of her academic research work, Dr Kuczek has a strong background in project and operations management. She has been responsible for the administrative management of large scale multi-institutional national and international projects, including in the area of hormone dependent cancers – a $5million NBCF (National Breast Cancer Foundation) national collaborative research program, and a Movember-NBCF collaborative linkage project. In 1997 she was instrumental in the establishment of the AGRF (Australian Genome Research Facility) in Brisbane, where for 10 years she managed the DNA sequencing services, and the wallaby genome project (at that time the largest genome to be sequenced in Australia), as well as general operations across the three AGRF nodes in Brisbane, Melbourne and Adelaide. Dr Kuczek’s multi-institutional project and stakeholder management was central to her space analyst role with the Go8 (Group of Eight) Facilities Directors group between 2013-2016.
As a community member of the consumer advisory group for PC4/PoCoG (Primary Care Collaborative Cancer Clinical Trials Group and Psycho-oncology Co-operative Research Group) she has maintained her interest in the translation of research into primary cancer care.
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Appointments
Date Position Institution name 2018 - ongoing Research Manager University of Adelaide 2013 - 2016 Go8 Space Project Manager University of Queensland 2008 - 2013 Project Manager University of Sydney 1997 - 2007 Divisional Manager / National Operations Manager Australian Genome Research Facility 1996 - 1997 National Product Manager Sarstedt AG 1992 - 1994 Staff Research Investigator Gladstone Institute for Virology and Immunology, UCSF -
Education
Date Institution name Country Title 1985 University of Adelaide Australia PhD 1981 University of Adelaide Australia BSc (Hons) 1980 University of Adelaide Australia BSc -
Postgraduate Training
Date Title Institution Country 1991 - 1992 Postdoctoral Fellow University of California San Francisco (UCSF) United States 1987 - 1990 Senior Research Officer Institute of Medical and Veterinary Science Australia
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Journals
Year Citation 2014 Hilton, H., Doan, T., Dinny Graham, J., Oakes, S., Silvestri, A., Santucci, N., . . . Clarke, C. (2014). Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease. Oncotarget, 5(18), 8651-8664.
Scopus24 WoS22 Europe PMC182014 Doan, T., Eriksson, N., Graham, D., Funder, J., Simpson, E., Kuczek, E., . . . Clarke, C. (2014). Breast cancer prognosis predicted by nuclear receptor-coregulator networks. Molecular Oncology, 8(5), 998-1013.
Scopus17 WoS16 Europe PMC112013 Muscat, G., Eriksson, N., Byth, K., Loi, S., Graham, D., Jindal, S., . . . Clarke, C. (2013). Research resource: Nuclear receptors as transcriptome: Discriminant and prognostic value in breast cancer. Molecular Endocrinology, 27(2), 350-365.
Scopus79 WoS82 Europe PMC692011 Renfree, M., Papenfuss, A., Deakin, J., Lindsay, J., Heider, T., Belov, K., . . . Hazar-Rethinam, M. (2011). Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development. Genome Biology, 12(8), R81-1-R81-25.
Scopus140 WoS145 Europe PMC1032008 Picardeau, M., Bulach, D. M., Bouchier, C., Zuerner, R. L., Zidane, N., Wilson, P. J., . . . Adler, B. (2008). Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis. PLoS ONE, 3(2), 9 pages.
Scopus247 WoS231 Europe PMC1772006 Bulach, D. M., Zuerner, R. L., Wilson, P., Seemann, T., McGrath, A., Cullen, P. A., . . . Adler, B. (2006). Genome reduction in Leptospira borgpetersenii reflects limited transmission potential. Proceedings of the National Academy of Sciences of the United States of America, 103(39), 14560-14565.
Scopus275 WoS265 Europe PMC2002006 Graves, J. A., & Kuczek, E. S. (2006). Marsupial Research Springs to the Forefront, Editorial. Australian Biochemist, 37(2), 3. 2006 Graves, J. A., & Kuczek, E. S. (2006). The Kangaroo Genome - Australia's Secret Weapon. Australian Biochemist, 37(2), 4-8. 2005 Premzl, M., Delbridge, M., Gready, J. E., Wilson, P., Johnson, M., Davis, J., . . . Marshall Graves, J. A. (2005). The prion protein gene: Identifying regulatory signals using marsupial sequence. Gene, 349, 121-134.
Scopus26 WoS24 Europe PMC202003 Saunders, N. F. W., Thomas, T., Curmi, P. M. G., Mattick, J. S., Kuczek, E., Slade, R., . . . Cavicchioli, R. (2003). Mechanisms of thermal adaptatation revealed from genomes of the anatarctic Archaea Methanogenium frigidum and Methanacoccoides burtonii. Genome Research, 13(7), 1580-1588.
Scopus205 WoS195 Europe PMC1172002 Barlow, J. W., Kuczek, E. S., Mitchelson, K. R., Ewen-White, K. R., & Forrest, S. M. (2002). Genomics research in Australia. Today's Life Science, 14(5), 5. 2001 Ross, B. C., Czajkowski, L., Hocking, D., Margetts, M., Webb, E., Rothel, L., . . . Barr, I. G. (2001). Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis. Vaccine, 19(30), 4135-4142.
Scopus122 WoS98 Europe PMC751995 Goldsmith, M. A., Lai, S. Y., Xu, W., Amaral, M. C., Kuczek, E. S., Parent, L. J., . . . Greene, W. C. (1995). Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the β chain and non-tyrosine residues of the γ(c) chain. Journal of Biological Chemistry, 270(37), 21729-21737.
Scopus63 WoS63 Europe PMC421994 Goldsmith, M. A., Xu, W., Amaral, M. C., Kuczek, E. S., & Greene, W. C. (1994). The cytoplasmic domain of the interleukin-2 receptor β chain contains both unique and functionally redundant signal transduction elements. Journal of Biological Chemistry, 269(20), 14698-14704.
Scopus55 WoS58 Europe PMC281992 Sivaprasad, A. V., Kuczek, E. S., Bawden, C. S., & Rogers, G. E. (1992). Coexpression of the cys E and cys M genes of Salmonella typhimurium in mammalian cells: a step towards establishing cysteine biosynthesis in sheep by transgenesis. Transgenic Research, 1(2), 79-92.
Scopus10 Europe PMC71991 Kuczek, E. S., Shannon, M. F., Pell, L. M., & Vadas, M. A. (1991). A granulocyte-colony-stimulating factor gene promoter element responsive to inflammatory mediators is functionally distinct from an identical sequence in the granulocyte-macrophage colony-stimulating factor gene. Journal of Immunology, 146(7), 2426-2433.
Scopus19 WoS23 Europe PMC101990 Shannon, M. F., Pell, L. M., Lenardo, M. J., Kuczek, E. S., Occhiodoro, F. S., Dunn, S. M., & Vadas, M. A. (1990). A Novel Tumor Necrosis Factor-Responsive Transcription Factor Which Recognizes a Regulatory Element in Hemopoietic Growth Factor Genes. Molecular and Cellular Biology, 10(6), 2950-2959.
Scopus46 WoS81 Europe PMC351989 Shannon, F., & Kuczek, E. (1989). Growth factors. Missing links in CSF gene expression. Today's Life Science, 1(2), 44-45. 1987 KUCZEK, E. S., & ROGERS, G. E. (1987). Sheep wool (glycine + tyrosine)‐rich keratin genes: A family of low sequence homology. European Journal of Biochemistry, 166(1), 79-85.
Scopus54 WoS54 Europe PMC311985 KUCZEK, E., & ROGERS, G. E. (1985). Sheep keratins: characterization of cDNA clones for the glycine + tyrosine‐rich wool proteins using a synthetic probe. European Journal of Biochemistry, 146(1), 89-93.
Scopus9 WoS14 Europe PMC9 -
Book Chapters
Year Citation 1989 The Biology of Wool and Hair (1989). Springer Netherlands.
1989 Powell, B., Kuczek, E. S., Crocker, L., O'Donnell, M., & Rogers, G. E. (1989). Keratin Gene Expression in Wool Fibre Development. In G. E. Rogers, P. J. Reis, K. A. Ward, & R. C. Marshall (Eds.), The Biology of Wool and Hair (pp. 325-335). Springer, Dordrecht.
1989 Rogers, G. E., Kuczek, E. S., Mackinnon, P. J., Presland, R. B., & Fietz, M. J. (1989). Special Biochemical Features of the Hair Follicle. In G. E. Rogers, P. J. Reis, K. A. Ward, & R. C. Marshall (Eds.), The Biology of Wool and Hair. Springer, Dordrecht.
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Committee Memberships
Date Role Committee Institution Country 2017 - 2018 Secretary Institutional Biosafety Committee University of Adelaide Australia 2012 - 2014 Member Wesley Hospital - Community Advisory Committee Wesley Private Hospital Australia 2011 - 2018 Member Joint Consumer Advisory Group (JCAG) PC4/POCOG (Primary Care Collaborative Cancer Clinical Trials / Pyscho-oncology Co-operative Research Group Australia
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