Yuliy Chirkov

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Dr Chirkov's current research focus is the clinical phenomenon of “clopidogrel resistance”. It appears that impairment in cyclic nucleotide signalling contributes to the pathophysiological mechanism of this condition.

Blood clots cause heart attacks and strokes. Clot formation can be prevented with special medication (e.g. clopidogrel or ticagrelor). Our research is aiming to identify a reason for the frequently occurring, less than expected response to medications designed to suppress increased blood clotting. We are focusing on platelets (little blood particles) because the starting point for blood clot formation is platelet aggregation, or platelet “clumping”. We have recently demonstrated that highly tuned regulation of platelet activity is compromised in patients with cardiovascular diseases. We are trying to work out what is going wrong with this regulation and how it could be restored. Our research will provide us with the insight into how to improve platelet regulation.

My Research
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Research Projects

Yuliy’s work interfaces basic research (“bench-side”) with extensive clinical access (“bed-side”). He has been directing projects investigating the interactions between cyclic nucleotide signalling pathways and oxidative stress in cardiovascular disease states.

Together with PhD and Honours students under his supervision, he has discovered and documented the phenomena of platelet “NO resistance” (nitric oxide, NO) and impaired cAMP signalling occurring in patients with ischaemic heart disease, and associated with thrombosis.

Dr Yuliy CHIRKOV is currently a Principal Medical Scientist (MeS-4), at The Queen Elizabeth Hospital (Central Adelaide Local Health Network, SA Health), and Senior Lecturer at The University of Adelaide. He has 110 career publications and a current H-index of 25.

Contributions to the field of Research:

Dr Chirkov has made a number of contributions to cardiovascular disease physiology and therapeutics. He studied the interactions of nitric oxide donors (e.g. nitroglycerine, sodium nitroprusside, S-nitrosothiols, etc.) with platelet aggregation. He has provided the first description of nitrate tolerance at the level of platelet aggregation in human subjects. He has documented the phenomenon of platelet nitrate/nitric oxide resistance in patients with cardiovascular diseases (stable angina, acute coronary syndromes, vasospastic angina, aortic stenosis, diabetes mellitus and congestive heart failure), with articles published in high-impact cardiac journals. He has shown that nitric oxide resistance can be ameliorated pharmacologically, with ACE-inhibitors, perhexiline and statins.

He studied the modulatory effects of angiotensin-(1-7) and angiotensin II on platelet aggregation and platelet responsiveness to nitric oxide. He has shown that angiotensin II exacerbates platelet aggregation, while angiotensin-(1-7) potentiates the anti-aggregatory action of the NO donors, and may therefore counteract platelet NO resistance. This finding also suggested an additional mechanism for the clinical effects of ACE-inhibitor therapy.

Recent research project was aimed on the circumvention of nitric oxide resistance with alternative, nitric oxide independent, stimulators of soluble guanylate cyclase, such as nitroxyl donors and direct activators of oxidised and haem-deficient guanylate cyclase (BAY 41-2272 and BAY 58-2667).

He is currently investigating a clinical phenomenon of “clopidogrel resistance”. It appears that impairment in cyclic nucleotide signalling contributes to the pathophysiological mechanism of this condition. Because the effects of ADP receptor antagonists such as clopidogrel and ticagrelor at the level of the P2Y12 receptor are coupled with changes in activity of AC, impaired response to PGE1 might imply both increased thrombotic risk and a reduced efficacy of anti-aggregatory drugs. Accordingly, patient response to treatment with clopidogrel is determined not only by variability of clopidogrel bio-activation, but also extensively by the integrity of platelet AC signalling.

Quality of research output:

Numerous publications in top-ranked cardiology journals. Editorials and invited reviews in Circulation, Thromb Haemost, Pharmacol Ther, J Am Heart Assoc, Expert Rev Cardiovasc Ther, Am J Cardiovasc Dis, Curr Opin Cardiol.

International standing:

International research collaboration: Since 1998, Dr Chirkov participated in a cooperative research project with Prof M.P. Frenneaux in UK (University of Wales Medical Centre, Cardiff; University of Birmingham; University of Aberdeen) related to investigation of endothelial-platelet dysfunction in heart failure and diabetes. Also, the investigation of the “Tako-tsubo” syndrome and effects of nitrite on blood vessels and platelets in cardiac patients.
International conferences: Since 1991, a total of 73 papers were presented at major international cardiac congresses held by World Heart Federation, American Heart Association and European Society of Cardiology. 18 papers were presented in the last 5 years

Publications

Over the past 5 years, Dr Chirkov had 17 publications in peer-reviewed journals.

Top 5 publications in the last 5 years:

Liu S et al. Suppression of neutrophil superoxide generation by BNP is attenuated in acute heart failure: a case for 'BNP resistance'. Eur J Heart Fail. 2015 Feb 11. This publication provided the first evidence of diminished responsiveness to the anti-inflammatory effects of BNP in patients with acute heart failure, which may account for the failure of nesiritide in the ASCEND-HF trial to reduce the rate of death and re-hospitalization.
Nooney VB et al. Post receptor determinants of acute platelet response to clopidogrel in patients with symptomatic myocardial ischemia. Vascul Pharmacol. 2015;65-66:17-22. Since adenylate cyclase (AC) and sGC pathways are variably impaired in ischaemic heart disease, we tested the relevance of these determinants to platelet response to clopidogrel. While genetically impaired bio-activation markedly limited acute clopidogrel response, impaired AC signalling provided an additional cause for clopidogrel resistance.
Hurst NL et al. Determinants of subacute response to clopidogrel: relative impact of CYP2C19 genotype and PGE₁/adenylate cyclase signalling. Thromb Res. 2015;136(2):308-14. A potential basis for clopidogrel resistance extends beyond impaired bioactivation. Pre-clopidogrel PGE₁ platelet response predicted clopidogrel response at 7 days. This was a stronger multivariate associate of response than bio-activator genotype.
Procter NE et al. New Developments in Platelet Cyclic Nucleotide Signalling: Therapeutic Implications. Cardiovasc Drugs Ther. 2016;30(5):505-513. Because the effects of ADP receptor antagonists such as clopidogrel and ticagrelor at the level of the P2Y12 receptor are coupled with changes in activity of AC, impaired response to PGE₁ might imply both increased thrombotic risk and a reduced efficacy of anti-aggregatory drugs. Accordingly, patient response to treatment with clopidogrel is determined not only by variability of clopidogrel bio-activation, but also extensively by the integrity of platelet AC signalling.
Liu S., Chirkov Y.Y, Horowitz J.D. Neutrophil-initiated myocardial inflammation and its modulation by B-type natriuretic peptide: a potential therapeutic target. Internat J Molec Sci. 2018 Dec 31;20(1). pii: E129. Activation of neutrophils is a critically important component of the innate immune response to bacterial and chemical stimuli, and culminates in the "neutrophil burst", which facilitates neutrophil phagocytosis via the release of superoxide anion radical (O₂-) from NADPH oxidase. We have demonstrated that B-type natriuretic peptide (BNP), acting via inhibition of activation of neutrophil NADPH oxidase, is an important negative modulator of the "neutrophil burst", though its effectiveness in limiting tissue injury is partially lost in acute heart failure. The potential therapeutic implications of these findings are discussed.

Appointments

Date	Position	Institution name
2014 - ongoing	Principal Medical Scientist	Queen Elizabeth Hospital
2014 - ongoing	Affiliate Senior Lecturer	University of Adelaide
2009 - 2014	Senior Research Fellow/Senior Lecturer	University of Adelaide
2001 - 2008	Senior Research Officer/Lecturer	University of Adelaide

Education

Date	Institution name	Country	Title
1988	Institute of Medical Enzymology	Russia	Senior Scientist
1978	Moscow State University/Institute of Biological Physics	Russia	PhD
1972	Moscow State University	Russia	Bachelor of Science

Research Interests

Cardiac, Respiratory and Vascular Health Innovative Therapeutics Biochemistry and Cell Biology Cardiology Cardiovascular Medicine and Haematology Physiology

Journals

Year	Citation
2023	Muminovic, A., Chirkov, Y. Y., & Horowitz, J. D. (2023). Effects of Soluble Guanylate Cyclase Stimulators and Activators on Anti-Aggregatory Signalling in Patients with Coronary Artery Spasm. International Journal of Molecular Sciences, 24(11), 11 pages. DOI
2023	Kei, C. Y., Singh, K., Dautov, R. F., Nguyen, T. H., Chirkov, Y. Y., & Horowitz, J. D. (2023). Coronary “Microvascular Dysfunction”: Evolving Understanding of Pathophysiology, Clinical Implications, and Potential Therapeutics. International Journal of Molecular Sciences, 24(14), 11287. DOI Scopus6 WoS2 Europe PMC3
2022	Chirkov, Y. Y., Nguyen, T. H., & Horowitz, J. D. (2022). Impairment of Anti-Aggregatory Responses to Nitric Oxide and Prostacyclin: Mechanisms and Clinical Implications in Cardiovascular Disease. International Journal of Molecular Sciences, 23(3), 21 pages. DOI Scopus13 WoS10 Europe PMC10
2022	Girolamo, O. C., Surikow, S. Y., Ong, G. J., Nguyen, T. H., Kucia, A. M., Chirkov, Y. Y., & Horowitz, J. D. (2022). TakoTsubo Syndrome: First an Acute Coronary Vasculitis and Then Prolonged Myocarditis?. Reviews in Cardiovascular Medicine, 23(5), 9 pages. DOI Scopus3 WoS3
2022	Chong, C. -R., Liu, S., Imam, H., Heresztyn, T., Sallustio, B. C., Chirkov, Y. Y., & Horowitz, J. D. (2022). Perhexiline Therapy in Patients with Type 2 Diabetes: Incremental Insulin Resistance despite Potentiation of Nitric Oxide Signaling. Biomedicines, 10(10), 2381-1-2381-10. DOI
2021	Ong, G. J., Nguyen, T. H., Kucia, A., Liu, S. -F., Surikow, S. Y., Girolamo, O., . . . Horowitz, J. D. (2021). Takotsubo syndrome: Finally emerging from the shadows?. Heart Lung and Circulation, 30(1), 36-44. DOI Scopus10 WoS9 Europe PMC4
2021	Imam, H., Nguyen, T. H., Stafford, I., Liu, S., Heresztyn, T., Chirkov, Y. Y., & Horowitz, J. D. (2021). Impairment of platelet NO signalling in coronary artery spasm: role of hydrogen sulphide. British Journal of Pharmacology, 178(7), 1639-1650. DOI Scopus11 WoS10 Europe PMC6
2021	Nguyen, T. H., Ong, G. J., Girolamo, O. C., De Menezes Caceres’, V., Muminovic, A., Chirkov, Y. Y., & Horowitz, J. D. (2021). Angina due to coronary artery spasm (variant angina): diagnosis and intervention strategies. Expert Review of Cardiovascular Therapy, 19(10), 917-927. DOI Scopus7 WoS4 Europe PMC5
2021	Nguyen, T. H., Surikow, S. Y., & Horowitz, J. D. (2021). Editorial commentary: Takotsubo Syndrome: A key role for inflammation?. Trends in Cardiovascular Medicine, 31(4), 231-232. DOI Scopus2 WoS2 Europe PMC1
2020	Aulin, J., Hijazi, Z., Siegbahn, A., Andersson, U., Alexander, J. H., Connolly, S. J., . . . Oldgren, J. (2020). Serial measurement of interleukin-6 and risk of mortality in anticoagulated patients with atrial fibrillation: Insights from ARISTOTLE and RE-LY trials. Journal of Thrombosis and Haemostasis, 18(9), 2287-2295. DOI Scopus12 WoS11 Europe PMC6
2020	Liu, S., Ngo, D., Chirkov, Y., Stansborough, J., Chong, C., & Horowitz, J. D. (2020). Prolonged suppression of the anti-oxidant/anti-inflammatory effects of BNP post-Takotsubo syndrome. ESC Heart Failure, 7(5), 2250-2257. DOI Scopus1 Europe PMC2
2020	Nooney, V. B., Hurst, N. L., De Caterina, R., Chirkov, Y. Y., & Horowitz, J. D. (2020). Does high on-treatment platelet aggregability reflect poor individual response to clopidogrel?. Thrombosis Research, 196, 510-515. DOI Scopus5 WoS5 Europe PMC3
2020	Horowitz, J. D., & Chong, C. -R. (2020). Matrix metalloproteinase-2 activation: critical to myocardial contractile dysfunction following ischaemia-reperfusion.. Cardiovascular research, 116(5), 876-878. DOI Scopus3 WoS3 Europe PMC3
2020	Iyngkaran, P., Thomas, M. C., Neil, C., Jelinek, M., Cooper, M., Horowitz, J. D., . . . Kaye, D. M. (2020). The Heart Failure with Preserved Ejection Fraction Conundrum—Redefining the Problem and Finding Common Ground?. Current Heart Failure Reports, 17(2), 34-42. DOI Scopus11 WoS9 Europe PMC8
2020	Nguyen, T., Chirkov, Y., Liu, S., Stafford, I., & Horowitz, J. (2020). Increased Rate of Hospitalization With Prinzmetal Angina: What Exactly Is Happening?. American Journal of Medicine, 133(4), e162-e163. DOI Scopus1 WoS1
2019	Imam, H., Nguyen, T. H., De Caterina, R., Nooney, V. B., Chong, C. R., Horowitz, J. D., & Chirkov, Y. Y. (2019). Impaired adenylate cyclase signaling in acute myocardial ischemia: Impact on effectiveness of P2Y<inf>12</inf> receptor antagonists. Thrombosis Research, 181, 92-98. DOI Scopus6 WoS4 Europe PMC2
2019	Liu, S., Chirkov, Y. Y., & Horowitz, J. D. (2019). Neutrophil-initiated myocardial inflammation and Its modulation by B-type natriuretic peptide: a potential therapeutic target. International Journal of Molecular Sciences, 20(1), 129-1-129-13. DOI Scopus5 WoS5 Europe PMC5
2018	Ajaero, C., Chong, C. -R., Procter, N., Liu, S., Chirkov, Y., Heresztyn, T., . . . Horowitz, J. (2018). Does cardiac resynchronization therapy restore peripheral circulatory homeostasis?. ESC heart failure, 5(1), 129-138. DOI Scopus1 WoS1 Europe PMC2
2016	Procter, N., Ball, J., Ngo, D., Isenberg, J., Hylek, E., Chirkov, Y., . . . Horowitz, J. (2016). Gender and tachycardia: independent modulation of platelet reactivity in patients with atrial fibrillation. Journal of Geriatric Cardiology, 13(3), 202-208. DOI WoS5 Europe PMC4
2016	Procter, N. E. K., Hurst, N. L., Nooney, V. B., Imam, H., De Caterina, R., Chirkov, Y. Y., & Horowitz, J. D. (2016). New Developments in Platelet Cyclic Nucleotide Signalling: Therapeutic Implications. Cardiovascular Drugs and Therapy, 30(5), 505-513. DOI Scopus8 WoS8 Europe PMC5
2016	Procter, N., Ball, J., Ngo, D., Chirkov, Y., Isenberg, J., Hylek, E., . . . Horowitz, J. (2016). Platelet hyperaggregability in patients with atrial fibrillation: Evidence of a background proinflammatory milieu. Herz, 41(1), 57-62. DOI Scopus9 WoS11 Europe PMC5
2015	Procter, N. E., Ball, J., Heresztyn, T., Nooney, V. B., Liu, S., Chong, C. -R., . . . Horowitz, J. D. (2015). Subtle renal dysfunction and bleeding risk in atrial fibrillation: symmetric dimethylarginine predicts HAS-BLED score.. American journal of cardiovascular disease, 5(2), 101-109. WoS1
2015	Liu, S., Ngo, D., Chong, C., Amarasekera, A., Procter, N., Licari, G., . . . Horowitz, J. (2015). Suppression of neutrophil superoxide generation by BNP is attenuated in acute heart failure: a case for 'BNP resistance'. European Journal of Heart Failure, 17(5), 475-483. DOI Scopus11 WoS9 Europe PMC8
2015	Nooney, V., Hurst, N., Chirkov, Y., De Caterina, R., & Horowitz, J. (2015). Post receptor determinants of acute platelet response to clopidogrel in patients with symptomatic myocardial ischemia. Vascular Pharmacology, 65-66, 17-22. DOI Scopus5 WoS5 Europe PMC1
2015	Hurst, N. L., Nooney, V. B., Chirkov, Y. Y., De Caterina, R., & Horowitz, J. D. (2015). Determinants of subacute response to clopidogrel: Relative impact of CYP2C19 genotype and PGE(1)/adenylate cyclase signalling. Thrombosis Research, 136(2), 308-314. DOI Scopus8 WoS8 Europe PMC3
2015	Chong, C., Liu, S., Licari, G., Heresztyn, T., Chirkov, Y., Ngo, D., & Horowitz, J. (2015). Reversal of hyperglycemia: effects on nitric oxide signaling. American Journal of Medicine, 128(4), 427-430. DOI Scopus6 WoS6 Europe PMC5
2014	Sverdlov, A., Ngo, D., Chan, W., Chirkov, Y., & Horowitz, J. (2014). Aging of the nitric oxide system: are we as old as our NO?. Journal of the American Heart Association, 3(4), e000973-1-e000973-12. DOI Scopus64 WoS53 Europe PMC40
2014	Liu, S., Ngo, D., Stewart, S., Horowitz, J., & Chirkov, Y. (2014). B-Type natriuretic peptide suppression of neutrophil superoxide generation: mechanistic studies in normal subjects. Clinical and Experimental Pharmacology and Physiology, 41(10), 739-743. DOI Scopus7 WoS7 Europe PMC6
2014	Chong, C., Chan, W., Nguyen, T., Liu, S., Procter, N., Ngo, D., . . . Horowitz, J. (2014). Thioredoxin-interacting protein: pathophysiology and emerging pharmacotherapeutics in cardiovascular disease and diabetes. Cardiovascular Drugs and Therapy, 28(4), 347-360. DOI Scopus70 WoS67 Europe PMC51
2014	Dautov, R., Stafford, I., Liu, S., Cullen, H., Chirkov, Y., & Horowitz, J. (2014). Hypoxic potentiation of nitrite effects in human vessels and platelets. Nitric Oxide: Biology and Chemistry, 40, 36-44. DOI Scopus20 WoS18 Europe PMC13
2014	Ali, O., Chapman, M., Thanh, H., Chirkov, Y., Heresztyn, T., Mundisugih, J., & Horowitz, J. (2014). Interactions between inflammatory activation and endothelial dysfunction selectively modulate valve disease progression in patients with bicuspid aortic valve. Heart, 100(10), 800-805. DOI Scopus37 WoS34 Europe PMC28
2013	Nguyen, T., Neil, C., Sverdlov, A., Ngo, D., Chan, W., Heresztyn, T., . . . Horowitz, J. (2013). Enhanced NO signaling in patients with Takotsubo cardiomyopathy: short-term pain, long-term gain?. Cardiovascular Drugs and Therapy, 27(6), 541-547. DOI Scopus36 WoS30 Europe PMC14
2013	Hurst, N., Nooney, V., Raman, B., Chirkov, Y., De Caterina, R., & Horowitz, J. (2013). Clopidogrel "resistance": Pre- vs post-receptor determinants. Vascular Pharmacology, 59(5-6), 152-161. DOI Scopus19 WoS17 Europe PMC9
2013	Sverdlov, A., Chan, W., Procter, N., Chirkov, Y., Ngo, D., & Horowitz, J. (2013). Reciprocal regulation of NO signaling and TXNIP expression in humans: Impact of aging and ramipril therapy. International Journal of Cardiology, 168(5), 4624-4630. DOI Scopus31 WoS34 Europe PMC26
2013	Dautov, R., Ngo, D., Licari, G., Liu, S., Sverdlov, A., Ritchie, R., . . . Chirkov, Y. (2013). The nitric oxide redox sibling nitroxyl partially circumvents impairment of platelet nitric oxide responsiveness. Nitric Oxide-Biology and Chemistry, 35, 72-78. DOI Scopus22 WoS21 Europe PMC11
2013	Chan, W., Ngo, D., Sverdlov, A., Rajendran, S., Stafford, I., Heresztyn, T., . . . Horowitz, J. (2013). Premature aging of cardiovascular/platelet function in polycystic ovarian syndrome. American Journal of Medicine, 126(7), 1-7. DOI Scopus13 WoS5 Europe PMC4
2012	Sverdlov, A., Ngo, D., Chan, W., Chirkov, Y., Gersh, B., McNeil, J., & Horowitz, J. (2012). Determinants of aortic sclerosis progression: implications regarding impairment of nitric oxide signalling and potential therapeutics. European Heart Journal, 33(19), 2419-2425. DOI Scopus26 WoS24 Europe PMC21
2012	Willoughby, S., Rajendran, S., Chan, W., Procter, N., Leslie, S., Liberts, E., . . . Horowitz, J. (2012). Ramipril sensitizes platelets to nitric oxide: Implications for therapy in high-risk patients. Journal of the American College of Cardiology, 60(10), 887-894. DOI Scopus44 WoS43 Europe PMC32
2012	Neil, C., Nguyen, T., Kucia, A., Crouch, B., Sverdlov, A., Chirkov, Y., . . . Horowitz, J. (2012). Slowly resolving global myocardial inflammation/oedema in Tako-Tsubo cardiomyopathy: evidence from T2-weighted cardiac MRI. Heart, 98(17), 1278-1284. DOI Scopus94 WoS85 Europe PMC59
2012	Neil, C., Nguyen, T., Sverdlov, A., Chirkov, Y., Chong, C., Stansborough, J., . . . Horowitz, J. (2012). Can we make sense of takotsubo cardiomyopathy? An update on pathogenesis, diagnosis and natural history. Expert Review of Cardiovascular Therapy, 10(2), 215-221. DOI Scopus20 WoS14 Europe PMC13
2011	Nguyen, T., Neil, C., Sverdlov, A., Mahadevan, G., Chirkov, Y., Kucia, A., . . . Horowitz, J. (2011). N-terminal pro-brain natriuretic protein levels in takotsubo cardiomyopathy. American Journal of Cardiology, 108(9), 1316-1321. DOI Scopus113 WoS97 Europe PMC78
2011	Ngo, D., Chan, W., Rajendran, S., Heresztyn, T., Amarasekera, A., Sverdlov, A., . . . Horowitz, J. (2011). Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D. Nitric Oxide-Biology and Chemistry, 25(3), 326-330. DOI Scopus56 WoS46 Europe PMC34
2011	Sverdlov, A., Ngo, D., Chapman, M., Ali, O., Chirkov, Y., & Horowitz, J. (2011). Pathogenesis of aortic stenosis: not just a matter of wear and tear. American Journal of Cardiovascular Disease, 1(2), 185-199. WoS44 Europe PMC28
2011	Chan, W. P. A., Sverdlov, A. L., Ngo, D. T., Rajendran, S., Chirkov, Y. Y., & Horowitz, J. D. (2011). Impact of ageing on the platelet and vascular responses in women with polycystic ovary syndrome. EUROPEAN HEART JOURNAL, 32, 171-172.
2011	Sverdlov, A. L., Ngo, D. T., Chan, W. P., Chapman, M. J., Chirkov, Y. Y., Gersh, B. J., . . . Horowitz, J. D. (2011). Progression of Early Aortic Valve Disease: Are ACE Inhibitors Protective?. CIRCULATION, 124(21), 2 pages.
2010	Horowitz, J., & Chirkov, Y. (2010). Perhexiline and hypertrophic cardiomyopathy: A new horizon for metabolic modulation. Circulation, 122(16), 1547-1549. DOI Scopus32 WoS30 Europe PMC20
2010	Horowitz, J., Chirkov, Y., Kennedy, J., & Sverdlov, A. (2010). Modulation of myocardial metabolism: an emerging therapeutic principle. Current Opinion in Cardiology, 25(4), 329-334. DOI Scopus43 WoS41 Europe PMC34
2010	Chirkov, Y., De Sciscio, M., Sverdlov, A., Leslie, S., Sage, P., & Horowitz, J. (2010). Hydralazine does not ameliorate nitric oxide resistance in chronic heart failure. Cardiovascular Drugs and Therapy, 24(2), 131-137. DOI Scopus9 WoS6 Europe PMC6
2009	Ngo, D., Sverdlov, A., Willoughby, S., Nightingale, A., Chirkov, Y., McNeil, J., & Horowitz, J. (2009). Determinants of occurrence of aortic sclerosis in an aging population. JACC: Cardiovascular Imaging, 2(8), 919-927. DOI Scopus40 WoS41 Europe PMC29
2008	Chirkov, Y., & Horowitz, J. (2008). Platelet nitric oxide resistance: Pathogenesis and clinical implications. Nitric Oxide-Biology and Chemistry, 19(Suppl 1), 58. DOI
2008	Horowitz, J., & Chirkov, Y. (2008). Identifying clopidogrel resistance during chronic therapy: The case for a biochemical approach. Thrombosis and Haemostasis, 100(4), 519-520. DOI Scopus2 WoS2 Europe PMC2
2008	Ngo, D., Stafford, I., Kelly, D., Sverdlov, A., Wuttke, R., Weedon, H., . . . Horowitz, J. (2008). Vitamin D2 supplementation induces the development of aortic stenosis in rabbits: Interactions with endothelial function and thioredoxin-interacting protein. European Journal of Pharmacology, 590(1-3), 290-296. DOI Scopus31 WoS35 Europe PMC23
2008	Rajendran, S., & Chirkov, Y. (2008). Platelet hyperaggregability: Impaired responsiveness to nitric oxide (“platelet NO resistance”) as a therapeutic target. Cardiovascular Drugs and Therapy, 22(3), 193-203. DOI Scopus31 WoS27 Europe PMC20
2007	Chirkov, Y., & Horowitz, J. (2007). Hyperglycemia and platelet function in diabetic patients: Relevance to acute myocardial ischemia and infarction. Cardiology Review, 24(12), 25-29.
2007	Chirkov, Y. (2007). Impaired tissue responsiveness to organic nitrates and nitric oxide: A new therapeutic frontier?. Pharmacology & Therapeutics, 116(2), 287-305. DOI Scopus80 WoS74 Europe PMC62
2007	Rajendran, S., Chirkov, Y., & Horowitz, J. (2007). Potentiation of platelet responsiveness to nitric oxide by angiotensin-(1-7) is associated with suppression of superoxide release. Platelets, 18(2), 158-164. DOI Scopus9 WoS8 Europe PMC6
2007	Worthley, M., Holmes, A., Willoughby, S., Kucia, A., Heresztyn, T., Stewart, S., . . . Horowitz, J. (2007). The deleterious effects of hyperglycemia on platelet function in diabetic patients with acute coronary syndromes - Mediation by superoxide production resolution with intensive insulin administration. Journal of the American College of Cardiology, 49(3), 304-310. DOI Scopus127 WoS114 Europe PMC85
2007	Ngo, D. T. M., Sverdlov, A. L., Willoughby, S. R., Nightingale, A. K., Chirkov, Y. Y., Mcneil, J. J., & Horowitz, J. D. (2007). Aortic valve sclerosis is associated with impaired platelet responsiveness to nitric oxide. EUROPEAN HEART JOURNAL, 28, 513.
2006	Chirkov, Y., Mishra, K., Chandy, S., Holmes, A., Kanna, R., & Horowitz, J. (2006). Loss of anti-aggregatory effects of aortic valve tissue in patients with aortic stenosis. Journal of Heart Valve Disease, 15(1), 28-33. Scopus13 WoS14 Europe PMC12
2005	Anderson, R., Ellis, G., Evans, L., Morris, K., Chirkov, Y., Horowitz, J., . . . Frenneaux, M. (2005). Platelet nitrate responsiveness in fasting and postprandial type 2 diabetes. Diabetes and Vascular Disease Research, 2(2), 88-93. DOI Scopus15 Europe PMC10
2005	Willoughby, S., Stewart, S., Holmes, A., Chirkov, Y., & Horowitz, J. (2005). Platelet nitric oxide responsiveness - A novel prognostic marker in acute coronary syndromes. Arteriosclerosis Thrombosis and Vascular Biology, 25(12), 2661-2666. DOI Scopus71 WoS65 Europe PMC56
2005	Rajendran, S., Chirkov, Y., Campbell, D., & Horowitz, J. (2005). Angiotensin-(1-7) enhances anti-aggregatory effects of the nitric oxide donor sodium nitroprusside. Journal of Cardiovascular Pharmacology, 46(4), 459-463. DOI Scopus18 WoS16 Europe PMC14
2005	Holmes, A., Chirkov, Y., Willoughby, S., Poropat, S., Pereira, J., & Horowitz, J. (2005). Preservation of platelet responsiveness to nitroglycerine despite development of vascular nitrate tolerance. British Journal of Clinical Pharmacology, 60(4), 355-363. DOI Scopus19 WoS21 Europe PMC10
2004	Chirkov, Y., Holmes, A., Martelli, J., & Horowitz, J. (2004). Effect of Perindopril on platelet nitric oxide resistance in patients with chronic heart failure secondary to ischemic left ventricular dysfunction. American Journal of Cardiology, 93(11), 1438-1440. DOI Scopus30 WoS28 Europe PMC21
2004	Anderson, R., Ellis, G., Chirkov, Y., Holmes, A., Payne, N., Blackman, D., . . . Frenneaux, M. (2004). Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure. European Journal of Heart Failure, 6(1), 47-54. DOI Scopus33 WoS42 Europe PMC22
2003	Stepien, J., Prideaux, R., Willoughby, S., Chirkov, Y., & Horowitz, J. (2003). Pilot study examining the effect of cholesterol lowering on platelet nitric oxide responsiveness and arterial stiffness in subjects with isolated mild hypercholesterolaemia. Clinical and Experimental Pharmacology and Physiology, 30(7), 507-512. DOI Scopus21 WoS23 Europe PMC13
2002	Willoughby, S., Stewart, S., Chirkov, Y., Kennedy, J., Holmes, A., & Horowitz, J. (2002). Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide. European Heart Journal, 23(24), 1946-1954. DOI Scopus52 WoS46 Europe PMC38
2002	Chirkov, Y., Holmes, A., Willoughby, S., Stewart, S., & Horowitz, J. (2002). Association of aortic stenosis with platelet hyperaggregability and impaired responsiveness to nitric oxide. American Journal of Cardiology, 90(5), 551-554. DOI Scopus38 WoS40 Europe PMC33
2002	James, K. A. C., Thompson, K. G., Maccoll, A. J., Booth, C. L., Body, D. R., Chirkov, Y. Y., . . . Lubbe, W. F. (2002). Platelet aggregation in pigs fed diets containing anhydrous milkfat, fish oil or hydrogenated coconut oil. Nutrition Research, 22(11), 1281-1298. DOI Scopus2
2001	Chirkov, Y., Holmes, A., Willoughby, S., Stewart, S., Wuttke, R., Sage, P., & Horowitz, J. (2001). Stable angina and acute coronary syndromes are associated with nitric oxide resistance in platelets. Journal of the American College of Cardiology, 37(7), 1851-1857. DOI Scopus74 WoS61 Europe PMC50
2001	Ellis, G., Anderson, R., Chirkov, Y., Morris-Thurgood, J., Jackson, S., Lewis, M., . . . Frenneaux, M. (2001). Acute effects of vitamin c on platelet responsiveness to nitric oxide donors and endothelial function in patients with chronic heart failure. Journal of Cardiovascular Pharmacology, 37(5), 564-570. DOI Scopus46 WoS45 Europe PMC35
2000	Chirkov, Y., Holmes, A., Chirkova, L., & Horowitz, J. (2000). Nitrate resistance in platelets from patients with stable angina pectoris - Response. Circulation, 102(11), E87.
2000	Anderson, R. A., Ellis, G. R., Chirkov, Y. Y., Blackman, D. J., Jackson, S. K., Lewis, M. J., . . . Frenneaux, M. P. (2000). Primary nitric oxide resistance and oxidative stress in patients with chronic heart failure. Heart, 83(SUPPL. 1).
1999	Tornvall, P., Chirkova, L., Toverud, K., Horowitz, J., Chirkov, Y., & Gustaf, K. (1999). Native and oxidized low density lipoproteins enhance platelet aggregation in whole blood. Thrombosis Research, 95(4), 177-183. DOI Scopus5 WoS5 Europe PMC3
1999	Chirkov, Y., Holmes, A., Chirkova, L., & Horowitz, J. (1999). Nitrate Resistance in platelets from patients with stable angina pectoris. Circulation, 100(2), 129-134. DOI Scopus84 WoS80 Europe PMC53
1998	Willoughby, S., Chirkov, Y., Kennedy, J., Murphy, G., Chirkova, L., & Horowitz, J. (1998). Inhibition of long-chain fatty acid metabolism does not affect platelet aggregation responses. European Journal of Pharmacology, 356(2-3), 207-213. DOI Scopus13 WoS14 Europe PMC7
1997	Chirkov, Y., Chirkova, L., & Horowitz, J. (1997). Nitroglycerin tolerance at the platelet level in patients with angina pectoris.. American Journal of Cardiology, 80(2), 128-131. DOI Scopus32 WoS32 Europe PMC25
1997	Willoughby, S. R., Chirkova, L. P., Horowitz, J. D., & Chirkov, Y. Y. (1997). Erratum: Multiple agonist induction of aggregation: An approach to examine anti-aggregating effects in vitro (Platelets (1996) 7 (329-333)). Platelets, 8(2-3), 191. DOI
1996	Willoughby, S., Chirkova, L., Horowitz, J., & Chirkov, Y. (1996). Multiple agonist induction of aggregation: an approach to examine anti-aggregating effects in vitro. Platelets, 7(5-6), 329-333. DOI Scopus6 WoS6 Europe PMC5
1996	Chirkov, Y., Chirkova, L., & Horowitz, J. (1996). Suppressed anti-aggregating and cGMP-elevating effects of sodium nitroprusside in platelets from patients with stable angina pectoris. Naunyn-Schmiedeberg's Archives of Pharmacology, 354(4), 520-525. DOI Scopus22 WoS24 Europe PMC16
1996	Chirkov, Y., & Horowitz, J. (1996). N-acetylcysteine potentiates nitroglycerin-induced reversal of platelet aggregation.. Journal of Cardiovascular Pharmacology, 28(3), 375-380. DOI Scopus22 WoS19 Europe PMC14
1995	Chirkov, Y. Y., Chirkova, L. P., Edward Sage, R., & Horowitz, J. D. (1995). Impaired responsiveness of platelets from patients with stable angina pectoris to antiaggregating and cyclicAMP-elevating effects of prostaglandin E<inf>1</inf>. Journal of Cardiovascular Pharmacology, 25(6), 961-966. DOI Scopus25 WoS24 Europe PMC15
1993	Chirkov, Y., Gee, D., Naujalis, J., Sage, R., & Horowitz, J. (1993). Reversal of ADP-induced platelet aggregation by S-nitrosothiols, nitroglycerine and nitroglycerine/N-acetylcysteine. Pharmacology Communications, 3(2), 97-105. Scopus6
1993	Chirkov, Y. Y., Naujalis, J. I., Edward Sage, R., & Horowitz, J. D. (1993). Antiplatelet effects of nitroglycerin in healthy subjects and in patients with stable angina pectoris. Journal of Cardiovascular Pharmacology, 21(3), 384-389. DOI Scopus50 WoS45 Europe PMC25
1992	Chirkov, Y. Y., Naujalis, J. I., Barber, S., Sage, R. E., Gove, D. W., Brealey, J. K., & Horowitz, J. D. (1992). Reversal of human platelet aggregation by low concentrations of nitroglycerin in vitro in normal subjects. The American Journal of Cardiology, 70(7), 802-806. DOI Scopus31 WoS27 Europe PMC21
1991	Chirkov, Y. Y., Belushkina, N. N., Tyshchuk, I. A., Severina, I. S., & Horowitz, J. D. (1991). INCREASE IN REACTIVITY OF HUMAN PLATELET GUANYLATE CYCLASE DURING AGGREGATION POTENTIATES THE DISAGGREGATING CAPACITY OF SODIUM NITROPRUSSIDE. Clinical and Experimental Pharmacology and Physiology, 18(7), 517-524. DOI Scopus19 WoS23 Europe PMC10
1991	Chirkov, Y. Y., Belushkina, N. N., Tyshchuk, I. A., & Severina, I. S. (1991). Changes in human platelet guanylate cyclase activity during ADP-induced aggregation. Byulleten Eksperimentalnoi Biologii i Meditsiny, 109(2), 152-154. Scopus4
1991	Chirkov, Y. Y., Belushkina, N. N., Tyshchuk, I. A., & Severina, I. S. (1991). Changes in guanylate cyclase activity of human platelets in adp-induced aggregation. Bulletin of Experimental Biology and Medicine, 111(2), 176-179. DOI
1990	Chirkov, Y. Y., Tyshchuk, I. A., & Severina, I. S. (1990). Correlation between rates of human thrombocytes aggregation and activation of the soluble guanylate cyclase. Voprosy Meditsinskoi Khimii, 36(4), 57-60. Scopus3
1990	Severina, I. S., Chirkov, Y. Y., Belushkina, N. N., Tyashchuk, I. A., Kulagin, S. V., & Khropov Yu., V. (1990). Effect of N-(6-aminohexyl)-5-chlor-naphthalene-1-sulfamide (W-7) and its analogs on the activity of soluble guanylate cyclase and on human platelet aggregation. Biokhimiya, 55(9), 1717-1724. Scopus2
1990	Chirkov, Y. Y., Tyshchuk, I. A., Severina, I. S., & Staroseltseva, L. K. (1990). ADP-induced aggregation of human thrombocytes in diabetes mellitus. Voprosy Meditsinskoi Khimii, 36(4), 20-22. Scopus1 Europe PMC1
1990	Chirkov, Y. Y., Tyshchuk, I. A., & Severina, I. S. (1990). Guanylate cyclase in human platelets with different aggregability. Experientia, 46(7), 697-699. DOI Scopus14 Europe PMC8
1989	Chirkov, Y. Y., Tyshchuk, I. A., Severina, I. S., & Starosel'tseva, L. K. (1989). Platelet guanylate cyclase in human diabetics. Bulletin of Experimental Biology and Medicine, 107(3), 326-328. DOI
1987	Chirkov, Y. Y., Tyshchyuk, I. A., Belushkina, N. N., & Severina, I. S. (1987). Guanylate cyclase from human blood platelets. Biokhimiya, 52(6), 956-963. Scopus16

Books

Year Citation
2010 Chirkov, Y., Sverdlov, A., & Horowitz, J. (2010). Beneficial effects of perhexiline in cardiovascular disease states. NOVA Science Publishers.

Year	Citation
2010	Chirkov, Y., Sverdlov, A., & Horowitz, J. (2010). Beneficial effects of perhexiline in cardiovascular disease states. NOVA Science Publishers.

Book Chapters

Year	Citation
2010	Chirkov, Y., Sverdlov, A., & Horowitz, J. (2010). Beneficial clinical effects of perhexiline in cardiac patients: Multiple biochemical mechanisms. In Horizons in World Cardiovascular Research Vol. 2, 2010 (pp. 1-27). NOVA Science Publishers.

Conference Papers

Year	Citation
2018	Imam, H., Nguyen, T. H., Tu, S., Tonnu, O., Chirkov, Y., & Horowitz, J. (2018). Pathogenesis of coronary artery spasm: a critical role for impaired platelet nitric oxide signaling. In EUROPEAN HEART JOURNAL Vol. 39 (pp. 336). Munich, GERMANY: OXFORD UNIV PRESS.
2017	Imam, H., Nguyen, T. H., Tee, S. -L., Tonnu, O., Chirkov, Y. Y., & Horowitz, J. D. (2017). Impaired cGMP and cAMP signaling in patients with coronary vasospasm: changes during acute crises. In EUROPEAN HEART JOURNAL Vol. 38 (pp. 794). OXFORD UNIV PRESS.
2017	Chong, C. -R., Imam, H., Sallustio, B., Chirkov, Y. Y., & Horowitz, J. D. (2017). Perhexiline enhances cGMP- and cAMP-signaling in diabetics independent of insulin sensitization and ACE inhibition. In EUROPEAN HEART JOURNAL Vol. 38 (pp. 1143). OXFORD UNIV PRESS.
2010	Chan, W. P., Ngo, D. T., Rajendran, S., Heresztyn, T., Amarasekera, A., Sverdlov, A. L., . . . Horowitz, J. D. (2010). Implications of insulin sensitivity on inflammatory activation and atherogenic risk in normal and PCOS females. In EUROPEAN HEART JOURNAL Vol. 31 (pp. 544). Stockholm, SWEDEN: OXFORD UNIV PRESS.
2006	Chirkov, Y. Y., Rajendran, S., Sverdlov, A. L., & Horowitz, J. D. (2006). Potentiation of platelet responsiveness to nitric oxide by angiotensin-(1-7) is mediated by its specific receptor and is associated with the suppression of superoxide release. In EUROPEAN HEART JOURNAL Vol. 27 (pp. 128). Barcelona, SPAIN: OXFORD UNIV PRESS.
2006	Ngo, D. T., Wuttke, R. D., Stafford, I., Rosenkranz, A. R., Sverdlov, A. L., Chirkov, Y. Y., . . . Horowitz, J. D. (2006). Effects of vitamin D2 supplementation on aortic valvular and vascular endothelial functions in a rabbit model of aortic stenosis. In EUROPEAN HEART JOURNAL Vol. 27 (pp. 127). Barcelona, SPAIN: OXFORD UNIV PRESS.
2003	Chirkov, Y. Y., Holmes, A. S., Chandy, S., & Horowitz, J. D. (2003). Aortic stenosis is associated with valvular endothelial dysfunction. In CIRCULATION Vol. 108 (pp. 431). ORLANDO, FLORIDA: LIPPINCOTT WILLIAMS & WILKINS.

Conference Items

Year	Citation
2019	Nguyen, T. H., Liu, S., Imam, H., Heresztyn, T., Stafford, I., Chirkov, Y. Y., & Horowitz, J. D. (2019). Pathogenesis of symptomatic crises in patients with coronary artery spasm: evidence for acute damage to vascular glycocalyx and to circulating platelets. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Paris, FRANCE: OXFORD UNIV PRESS.
2017	Imam, H., Nguyen, T. H., Chirkov, Y., De Caterina, R., & Horowitz, J. (2017). Adenylate cyclase signaling is an important post-receptor determinant of response to all P2Y12 receptor antagonists. Poster session presented at the meeting of European Heart Journal. Barcelona: Oxford University Press. DOI
2016	Procter, N. E. K., Ball, J., Ngo, D. T. M., Chirkov, Y. Y., Stewart, S., & Horowitz, J. D. (2016). Platelet hypo-responsiveness to nitric oxide in new onset atrial fibrillation has a physiological, as opposed to pharmacological, basis. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Rome, ITALY: OXFORD UNIV PRESS.
2015	Liu, S., Ngo, D. T., Chong, C. R., Chan, W. P., Horowitz, J. D., & Chirkov, Y. Y. (2015). Tachyphylaxis to the anti-inflammatory effects of BNP in acute heart failure:-potential response to therapy. Poster session presented at the meeting of EUROPEAN JOURNAL OF HEART FAILURE. WILEY-BLACKWELL.
2014	Nooney, V. B., Chirkov, Y. Y., De Caterina, R., & Horowitz, J. D. (2014). Ticagrelor potentiates the anti-aggregatory effects of adenosine via A2 receptor stimulation. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Barcelona, SPAIN: OXFORD UNIV PRESS.
2014	Procter, N. E. K., Ball, J., Ngo, D. T. M., Chirkov, Y. Y., Isenberg, J. S., Hylek, E. M., . . . Horowitz, J. D. (2014). Gender/tachycardia interactions in atrial fibrillation: impact upon platelet aggregation and nitric oxide signalling. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Barcelona, SPAIN: OXFORD UNIV PRESS.
2014	Liu, S., Ngo, D., Chong, C. -R., Chirkov, Y., Stewart, S., & Horowitz, J. (2014). Mechanisms of BNP interactions with neutrophil superoxide release: attenuation in acute and chronic heart failure. Poster session presented at the meeting of Global Heart.
2013	Liu, S., Ngo, D., Chirkov, Y., Stewart, S., & Horowitz, J. (2013). Impaired B-type natriuretic peptide effets on neutrophil burst in heart failure patients. Poster session presented at the meeting of Abstracts of the American Heart Association 2013 Scientific Sessions and Resuscitation Science Symposium, as publshed in Circulation. Dallas, TX: American Heart Association.
2013	Amarasekera, A., Black, M., Jansen, F., Dymmott, G., Roberts, M., Chirkov, Y., . . . Ngo, D. (2013). Vitamin D supplementation in healthy adults lowers plasma Thrombospondin-1 levels: a novel vitamin D target?. Poster session presented at the meeting of Abstracts of the American Heart Association 2013 Scientific Sessions and Resuscitation Science Symposium, as publshed in Circulation. Dallas, TX: American Heart Association.
2013	Chong, C., Liu, S., Licari, G., Chirkov, Y., Ngo, D., & Horowitz, J. (2013). Reversal of acute hyperglycemia restores tissue responsiveness to nitric oxide and improves endothelial progenitor cell function without downregulating platelet thioredoxin interacting protein. Poster session presented at the meeting of Abstracts of the American Heart Association 2013 Scientific Sessions and Resuscitation Science Symposium, as publshed in Circulation. Dallas, TX: American Heart Association.
2013	Nguyen, T. H., Neil, C., Singh, K., Heresztyn, T., Chirkov, Y., & Horowitz, J. (2013). Determinants of prolonged impairment of global longitudinal strain post Takotsubo cardiomyopathy. Poster session presented at the meeting of Abstracts of the European Society of Cardiology Congress 2013 (ESC 2013), as published in European Heart Journal. Amsterdam, NETHERLANDS: Oxford University Press. DOI
2013	Nooney, V. B., Hurst, N., Chirkov, Y. Y., & Horowitz, J. H. (2013). Acute effects of clopidogrel are predicted by integrity of prostacyclin signalling. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Amsterdam, NETHERLANDS: OXFORD UNIV PRESS.
2012	Nguyen, T. H., Neil, A., Sverdlov, A., Ngo, D., Chan, W., Chirkov, Y., . . . Horowitz, J. (2012). Paradoxical preservation of NO signalling in Takotsubo cardiomyopathy. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Munchen, GERMANY: OXFORD UNIV PRESS.
2012	Procter, N. E. K., Ball, J., Carrington, M., Nguyen, T. H., Ngo, D., Chirkov, Y. Y., . . . Horowitz, J. D. (2012). Determinants of platelet response to nitric oxide in association with atrial fibrillation: evidence for an acute suppression of response. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Munchen, GERMANY: OXFORD UNIV PRESS.
2012	Liu, S., Ngo, D. T., Chirkov, Y. Y., Sheikh, A. R., Licari, G., Stewart, S., & Horowitz, J. D. (2012). Brain Natriuretic Peptide (BNP) Suppresses Neutrophil Superoxide Release: Attenuation in Patients with Congestive Heart Failure (CHF). Poster session presented at the meeting of CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS.
2012	Bullen, M. L., Miller, A. A., Drummond, G. R., Sobey, C. G., Stasch, J. -P., Chirkov, Y. Y., . . . Kemp-Harper, B. K. (2012). Nitric Oxide-Independent Stimulators of Soluble Guanylyl Cyclase Circumvent Platelet Nitric Oxide Resistance in Hypercholesterolemic Mice. Poster session presented at the meeting of CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS.
2011	Sverdlov, A. L., Ngo, D. T. M., Chirkov, Y. Y., & Horowitz, J. D. (2011). Insights into the initiation of aortic stenosis: roles of ACE-inhibitors and vitamin D. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. OXFORD UNIV PRESS.
2011	Chan, W. P. A., Sverdlov, A. L., Ngo, D. T., Chirkov, Y. Y., & Horowitz, J. D. (2011). Does oral contraceptive therapy induce platelet nitric oxide resistance?. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. OXFORD UNIV PRESS.
2011	Sverdlov, A. L., Ngo, D. T. M., Chirkov, Y. Y., & Horowitz, J. D. (2011). Insights into the initiation of aortic stenosis: roles of ACE-inhibitors and vitamin D. Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC.
2008	Chirkov, Y. Y., De Sciscio, M., Sverdlov, A. L., Leslie, S., & Horowitz, J. D. (2008). Is there a pharmacological hydralazine/nitrate interaction in chronic heart failure?. Poster session presented at the meeting of Abstracts of ESC Congress 2008, as published in European Heart Journal. Munich, Germany: Oxford University Press. DOI WoS1

Grants and Funding

Date	Funding Body	Funding Title
2017-2019	NHMRC	"Therapeutic approaches to circumvent nitric oxide resistance in the type II diabeticheart and vasculature: Myocardial relaxation in response to NO donors"
2009-2014	The Queen Elizabeth Hospital	TQEH vascular disease and therapeutics research group: towards improved outcomes for vascular disease
2007-2008	National Heart Foundation of Australia	Modulation of myocardial metabolism in heart failure: implications regarding inflammation, vascular, platelet and myocardial function
2004-2005	National Heart Foundation of Australia	Mechanisms of therapeutic effect of perhexiline in severe myocardial ischaemia
2002-2002	NHMRC	Berthold Model LB953 Autolumat Plus tube luminometer

Dr Chirkov was responsible for training of both undergraduate and postgraduate students, a total of 29, in the role of lecturer and research supervisor. In the last 5 years, he supervised 7 PhD students.

Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2022	Co-Supervisor	Investigating cardiovascular complications of diabetes	Doctor of Philosophy	Doctorate	Full Time	Mr Getandale Zeleke Negera

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2015 - 2018	Co-Supervisor	Inter-Individual Variability in Platelet Adenylate and Soluble Guanylate Cyclase Signaling: Therapeutic Perspectives	Doctor of Philosophy	Doctorate	Full Time	Mr Md Hasan Imam
2015 - 2022	Co-Supervisor	Takotsubo Syndrome: Precipitants, Clinical Course and Emerging Treatments	Doctor of Philosophy	Doctorate	Part Time	Mr Gao Jing Ong
2014 - 2019	Co-Supervisor	Nitrosative Stress and the Pathogenesis of Takotsubo Syndrome: Insights from a Novel Female Rat Model	Doctor of Philosophy	Doctorate	Full Time	Mr Sven Yuri Surikow
2012 - 2015	Co-Supervisor	Natural History and Pathogenesis of Takotsubo Cardiomyopathy	Doctor of Philosophy	Doctorate	Full Time	Dr Kuljit Singh
2011 - 2015	Co-Supervisor	Effects of Nitrite and Nitroxyl on Human Vascular and Platelet Function	Doctor of Philosophy	Doctorate	Full Time	Dr Rustem Dautov
2011 - 2016	Co-Supervisor	Post-P2Y 12-Receptor Signalling Mechanisms and Platelet Responses to Clopidogrel	Doctor of Philosophy	Doctorate	Full Time	Dr Nicola Hurst
2010 - 2015	Co-Supervisor	Variability of Nitric Oxide Signalling in Atrial Fibrillation: Potential Modulation	Doctor of Philosophy	Doctorate	Part Time	Mr Nathan Edward Kevin Procter
2010 - 2015	Co-Supervisor	Impaired Tissue Responsiveness to B-Type Natriuretic Peptide in Heart Failure: Biochemical Bases	Doctor of Philosophy	Doctorate	Full Time	Dr Saifei Liu
2009 - 2012	Co-Supervisor	Pathogenesis of Aortic Stenosis: Implications Regarding Impairment of Nitric Oxide Signalling	Doctor of Philosophy	Doctorate	Full Time	Dr Aaron Sverdlov
2009 - 2013	Co-Supervisor	Cardiovascular Risk Assessment in Women: Impact of Ageing, Polycystic Ovarian Syndrome and Menopause on Nitric Oxide Signalling	Doctor of Philosophy	Doctorate	Full Time	Dr Alicia Chan
2005 - 2009	Co-Supervisor	Platelet and Endothelial Function: Polycystic Ovary Syndrome and the Renin-Angiotensin System	Doctor of Philosophy	Doctorate	Full Time	Dr Sharmalar Rajendran
1998 - 2003	Co-Supervisor	Pathophysiological and platelet anti-aggregatory effects of nitric oxide	Doctor of Philosophy	Doctorate	Full Time	Dr Andrew Holmes

Committee Memberships

Date Role Committee Institution Country
2009 - ongoing Member QEH Research Day Conference Organising Committee Queen Elizabeth Hospital Australia

Date	Role	Committee	Institution	Country
2009 - ongoing	Member	QEH Research Day Conference Organising Committee	Queen Elizabeth Hospital	Australia

Review, Assessment, Editorial and Advice

Date	Title	Type	Institution	Country
2003 - ongoing	Assessor	Grant Assessment	National Health and Medical Research Council	Australia
2003 - ongoing	Peer reviewer in the area of cardiovascular research (physiology and biochemistry)	Journal Review	"Heart, Lung and Circulation", "Cardiovascular Research", "Cardiovascular Drugs and Therapy", "Nitric Oxide" and "Clinical and Experimental Pharmacology and Physiology"	-

Email: yuliy.chirkov@adelaide.edu.au