Yue Hui

School of Chemical Engineering

Faculty of Sciences, Engineering and Technology

My Research
Career
Publications
Grants and Funding
Supervision
Professional Activities
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As an Investigator Grant recipient, I am an NHMRC EL1 fellow (2024-2028), and my research focuses on the development of advanced biomaterials for biomedical applications.

My current research primarily involves the development of hydrogel-based bioelectronics for reparing cardiac infarction, utilising soft matters (hydrogels), flexible electronics, and extrusion-based additive manufacturing (3D printing). I have developed materials and methods for embedded 3D printing to fabricate conductive hydrogels and hydrogel-based functional soft electronic devices for biomedical purposes such as signal sensing, electrical stimulating and tissue engineering.

I also have extensive experience in engineering nano- and micro-sized biomaterials for tumour-targeted drug delivery. I have developed nano-systems with adjustable mechanical properties (Young’s moduli) and have investigated how nanoparticle’s mechanical properties affect the interactions at the bio-nano interface. Currently, I am supervising PhD students working on the development of nano- and microparticle-based artificial antigen presenting cells (aAPCs) with varying stiffness for T cell activation for cancer immunotherapy.

Additionally, I possess experiece in microfluidics, organs-on-chips, and light-based 3D printing techniques.

Appointments

Date	Position	Institution name
2022 - ongoing	Postdoctoral Research Fellow	University of Adelaide
2019 - 2021	Postdoctoral Research Fellow	Westlake University
2019 - 2019	Senior Research Technician	University of Queensland

Language Competencies

Language Competency
Chinese (Mandarin) Can read, write, speak, understand spoken and peer review
English Can read, write, speak, understand spoken and peer review
Education

Date Institution name Country Title
2014 - 2019 University of Queensland Australia PhD
2010 - 2014 Xi'an Jiaotong University China BEng
Research Interests

Biomaterials Nanomedicine

Language	Competency
Chinese (Mandarin)	Can read, write, speak, understand spoken and peer review
English	Can read, write, speak, understand spoken and peer review

Date	Institution name	Country	Title
2014 - 2019	University of Queensland	Australia	PhD
2010 - 2014	Xi'an Jiaotong University	China	BEng

Journals

Year	Citation
2024	Hou, F., Guo, Z., Ho, M. T., Hui, Y., & Zhao, C. -X. (2024). Particle-Based Artificial Antigen-Presenting Cell Systems for T Cell Activation in Adoptive T Cell Therapy. ACS Nano, 18(12), 8571-8599. DOI Scopus2
2024	Weng, Y., Chen, R., Hui, Y., Chen, D., & Zhao, C. -X. (2024). Boosting Enzyme Activity in Enzyme Metal-Organic Framework Composites.. Chem & bio engineering, 1(2), 99-112. DOI Europe PMC1
2023	Yang, G., Liu, Y., Jin, S., Hui, Y., Wang, X., Xu, L., . . . Zhao, C. (2023). Phase separation‐induced nanoprecipitation for making polymer nanoparticles with high drug loading. Aggregate, 4(2), e314-1-e314-9. DOI Scopus8 WoS1
2023	Yao, Y., Hui, Y., Wang, Z., Chen, H., Zhu, H., & Zhou, N. (2023). Granular Ionogel Particle Inks for 3D Printed Tough and Stretchable Ionotronics.. Research (Washington, D.C.), 6, 14 pages. DOI Scopus8
2023	Chen, H., Wang, J., Peng, S., Liu, D., Yan, W., Shang, X., . . . Zhou, N. (2023). A Generalized Polymer Precursor Ink Design for 3D Printing of Functional Metal Oxides.. Nano-micro letters, 15(1), 1-16. DOI Scopus5
2022	Hui, Y., Yao, Y., Qian, Q., Luo, J., Chen, H., Qiao, Z., . . . Zhou, N. (2022). Three-dimensional printing of soft hydrogel electronics. Nature Electronics, 5(12), 893-903. DOI Scopus70 WoS20
2022	Zou, D., Wu, Z., Yi, X., Hui, Y., Yang, G., Liu, Y., . . . Zhao, C. -X. (2022). Nanoparticle elasticity regulates the formation of cell membrane-coated nanoparticles and their nano-bio interactions. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 120(1), 1-12. DOI Scopus23 WoS6 Europe PMC7
2022	Tengjisi., Hui, Y., Fan, Y., Zou, D., Talbo, G. H., Yang, G., & Zhao, C. X. (2022). Influence of nanoparticle mechanical property on protein corona formation. Journal of Colloid and Interface Science, 606(2), 1737-1744. DOI Scopus27 WoS15 Europe PMC7
2022	Liu, Y., Yang, G., Hui, Y., Ranaweera, S., & Zhao, C. -X. (2022). Microfluidic Nanoparticles for Drug Delivery. Small, 18(36), 33 pages. DOI Scopus103 WoS35 Europe PMC24
2022	Chen, H., Min, X., Hui, Y., Qin, W., Zhang, B., Yao, Y., . . . Zhou, N. (2022). Colloidal oxide nanoparticle inks for micrometer-resolution additive manufacturing of three-dimensional gas sensors. Materials Horizons, 9(2), 764-771. DOI Scopus7 WoS4 Europe PMC1
2022	Zhang, H., Yao, Y., Hui, Y., Zhang, L., Zhou, N., & Ju, F. (2022). A 3D-printed microfluidic gradient concentration chip for rapid antibiotic-susceptibility testing. Bio-Design and Manufacturing, 5(1), 210-219. DOI Scopus18 WoS5
2021	Wilson, R. J., Hui, Y., Whittaker, A. K., & Zhao, C. X. (2021). Facile bioinspired synthesis of iron oxide encapsulating silica nanocapsules. Journal of Colloid and Interface Science, 601, 78-84. DOI Scopus18 WoS11 Europe PMC7
2021	Yang, G., Liu, Y., Hui, Y., Tengjisi., Chen, D., Weitz, D. A., & Zhao, C. X. (2021). Implications of Quenching-to-Dequenching Switch in Quantitative Cell Uptake and Biodistribution of Dye-Labeled Nanoparticles. Angewandte Chemie - International Edition, 60(28), 15426-15435. DOI Scopus16 WoS10
2021	Tengjisi., Hui, Y., Yang, G., Fu, C., Liu, Y., & Zhao, C. X. (2021). Biomimetic core–shell silica nanoparticles using a dual-functional peptide. Journal of Colloid and Interface Science, 581(A), 185-194. DOI Scopus16 WoS12 Europe PMC4
2020	Zou, D., Yu, L., Sun, Q., Hui, Y., Tengjisi., Liu, Y., . . . Zhao, C. X. (2020). A general approach for biomimetic mineralization of MOF particles using biomolecules. Colloids and Surfaces B: Biointerfaces, 193, 1-9. DOI Scopus34 WoS29 Europe PMC7
2020	Zou, D., Yu, L., Sun, Q., Hui, Y., Jisi, T., Liu, Y., . . . Zhao, C. -X. (2020). A General Approach for Encapsulation of Biomolecules Using MOF Particles. DOI
2020	Liu, Y., Yang, G., Zou, D., Hui, Y., Nigam, K., Middelberg, A. P. J., & Zhao, C. X. (2020). Formulation of nanoparticles using mixing-induced nanoprecipitation for drug delivery. Industrial and Engineering Chemistry Research, 59(9), 4134-4149. DOI Scopus121 WoS83
2020	Hui, Y., Yi, X., Wibowo, D., Yang, G., Middelberg, A. P. J., Gao, H., & Zhao, C. X. (2020). Nanoparticle elasticity regulates phagocytosis and cancer cell uptake. Science Advances, 6(16), 1-11. DOI Scopus142 WoS106 Europe PMC37
2019	Hui, Y., Yi, X., Hou, F., Wibowo, D., Zhang, F., Zhao, D., . . . Zhao, C. X. (2019). Role of nanoparticle mechanical properties in cancer drug delivery. ACS Nano, 13(7), 7410-7424. DOI Scopus255 WoS187 Europe PMC65
2019	Ran, R., Wang, H. F., Hou, F., Liu, Y., Hui, Y., Petrovsky, N., . . . Zhao, C. X. (2019). A microfluidic tumor-on-a-chip for assessing multifunctional liposomes' tumor targeting and anticancer efficacy. Advanced Healthcare Materials, 8(8), 1-10. DOI Scopus50 WoS35 Europe PMC18
2019	Yu, L., Sun, Q., Hui, Y., Seth, A., Petrovsky, N., & Zhao, C. X. (2019). Microfluidic formation of core-shell alginate microparticles for protein encapsulation and controlled release. Journal of Colloid and Interface Science, 539, 497-503. DOI Scopus111 WoS89 Europe PMC27
2019	Peters, B. C., Wibowo, D., Yang, G. Z., Hui, Y., Middelberg, A. P. J., & Zhao, C. X. (2019). Evaluation of baiting fipronil-loaded silica nanocapsules against termite colonies in fields. Heliyon, 5(8), e02277-1-e02277-10. DOI Scopus14 WoS6 Europe PMC3
2019	Yang, G., Liu, Y., Wang, H., Wilson, R., Hui, Y., Yu, L., . . . Zhao, C. X. (2019). Bioinspired core-shell nanoparticles for hydrophobic drug delivery. Angewandte Chemie - International Edition, 58(40), 14357-14364. DOI Scopus94 WoS55 Europe PMC25
2018	Hui, Y., Wibowo, D., Liu, Y., Ran, R., Wang, H., Seth, A., . . . Zhao, C. (2018). Understanding the effects of nanocapsular mechanical property on passive and active tumor targeting. ACS Nano, 12(3), 2846-2857. DOI Scopus129 WoS102 Europe PMC30
2018	Liu, Y., Hui, Y., Ran, R., Yang, G. Z., Wibowo, D., Wang, H. F., . . . Zhao, C. X. (2018). Synergetic combinations of dual-targeting ligands for enhanced in vitro and in vivo tumor targeting. Advanced Healthcare Materials, 7(15), 1800106-1-1800106-11. DOI Scopus48 WoS41 Europe PMC10
2018	Ran, R., Wang, H., Liu, Y., Hui, Y., Sun, Q., Seth, A., . . . Zhao, C. X. (2018). Microfluidic self-assembly of a combinatorial library of single- and dual-ligand liposomes for in vitro and in vivo tumor targeting. European Journal of Pharmaceutics and Biopharmaceutics, 130, 1-10. DOI Scopus56 WoS50 Europe PMC17
2018	Wang, H. F., Ran, R., Liu, Y., Hui, Y., Zeng, B., Chen, D., . . . Zhao, C. X. (2018). Tumor-Vasculature-on-a-Chip for Investigating Nanoparticle Extravasation and Tumor Accumulation. ACS Nano, 12(11), 11600-11609. DOI Scopus109 WoS93 Europe PMC47
2018	Sun, Q., Tan, S. H., Chen, Q., Ran, R., Hui, Y., Chen, D., & Zhao, C. X. (2018). Microfluidic Formation of Coculture Tumor Spheroids with Stromal Cells As a Novel 3D Tumor Model for Drug Testing. ACS Biomaterials Science and Engineering, 4(12), 4425-4433. DOI Scopus69 WoS56 Europe PMC23
2017	Zhao, C., Chen, D., Hui, Y., Weitz, D., & Middelberg, A. (2017). Controlled generation of ultrathin-shell double emulsions and studies on their stability. ChemPhysChem, 18(10), 1393-1399. DOI Scopus28 WoS26 Europe PMC9
2016	Wibowo, D., Hui, Y., Middelberg, A., & Zhao, C. (2016). Interfacial engineering for silica nanocapsules. Advances in Colloid and Interface Science, 236, 83-100. DOI Scopus38 WoS34 Europe PMC9
2016	Zhao, C., Chen, D., Hui, Y., Weitz, D., & Middelberg, A. (2016). Stable ultrathin-shell double emulsions for controlled release. ChemPhysChem, 17(11), 1553-1556. DOI Scopus25 WoS24 Europe PMC7
2016	Hui, Y., Wibowo, D., & Zhao, C. X. (2016). Insights into the Role of Biomineralizing Peptide Surfactants on Making Nanoemulsion-Templated Silica Nanocapsules. Langmuir, 32(3), 822-830. DOI Scopus15 WoS15 Europe PMC1

Theses

Year Citation
- Hui, Y. (n.d.). Bio-inspired silica nanocapsules for understanding in vitro and in vivo nano-bio interactions.
Preprint

Year Citation
2022 Hui, Y., Qian, Q., Yao, Y., Chen, H., Qiao, Z., Yu, Y., & Zhou, N. (2022). Freeform 3D Printing of Soft Hydrogel Electronics.
DOI

Year	Citation
-	Hui, Y. (n.d.). Bio-inspired silica nanocapsules for understanding in vitro and in vivo nano-bio interactions.

Year	Citation
2022	Hui, Y., Qian, Q., Yao, Y., Chen, H., Qiao, Z., Yu, Y., & Zhou, N. (2022). Freeform 3D Printing of Soft Hydrogel Electronics. DOI

AEA Seed grant: AU$ 299K, 2024-2025, leading CI.
NHMRC Investigator Grant (EL1): AU$ 662K, 2024-2028, Sole CI.
Westlake University postdoc research grant: Approx. AU$ 20K, 2019-2021, Sole CI.

Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2024	Principal Supervisor	Development of anti-swelling hydrogels for next-generation soft electronics	Doctor of Philosophy	Doctorate	Full Time	Mr Geng Yang
2024	Principal Supervisor	Development of integrated microfluidic chips for making mRNA nanomedicines	Doctor of Philosophy	Doctorate	Full Time	Vincent Patrick Linden
2023	Co-Supervisor	Development of Cancer-on-a-Chip Platforms for Drug Screening	Doctor of Philosophy	Doctorate	Full Time	Mr Max George Higham
2022	Co-Supervisor	Engineering Microparticle-based Artificial Antigen Presenting Cells for T-cell Activation in Immunotherapy	Doctor of Philosophy	Doctorate	Full Time	Mr Fei Hou
2022	Co-Supervisor	Development of Lymph-node-on-chip microfluidic platform for vaccine evaluation.	Doctor of Philosophy	Doctorate	Full Time	Mr Supun Akash Ranaweera
2022	Co-Supervisor	Effects of mechanical properties of precision-engineered nanoscale aAPCs on T cell activation and expansion	Doctor of Philosophy	Doctorate	Full Time	Mr Zichao Guo
2022	Co-Supervisor	Development of novel lipid nanoparticles for mRNA delivery	Doctor of Philosophy	Doctorate	Full Time	Mr Xing Wang
2022	Co-Supervisor	Development of mRNA loaded Lipid Nanoparticles for CAR T Cell Therapy	Doctor of Philosophy	Doctorate	Full Time	Ms Minh Trang Ho

Mentoring

Date	Topic	Location	Name
2020 - 2021	A 3D-printed microfluidic gradient concentration chip for rapid antibiotic-susceptibility testing	Westlake University	Huilin Zhang
2020 - 2021	Colloidal oxide nanoparticle inks for micrometer-resolution additive manufacturing of three-dimensional gas sensors	Westlake University	Hehao Chen
2020 - 2020	3D printing of soft hydrogel electronics	Westlake University	Zheng Qiao
2018 - 2018	Impact of nanoparticle stiffness in cancer drug delivery	The University of Queensland	Fei Hou
2018 - 2018	Impact of nanoparticle stiffness in cancer drug delivery	The University of Queensland	Mingxuan Wan

Memberships

Date Role Membership Country
2017 - ongoing Member The Australian Nanotechnology Network Australia
Community Engagement

Date Title Engagement Type Institution Country
2020 - 2021 Member of Postdoc Committee Public Community Engagement Westlake University -
Event Participation

Date Event Name Event Type Institution Country
2022 - 2022 2022 Exploration Australian Multidisciplinary Webinar Conference 2022 Australian Australian Multidisciplinary Webinar Australia

Date	Role	Membership	Country
2017 - ongoing	Member	The Australian Nanotechnology Network	Australia

Date	Title	Engagement Type	Institution	Country
2020 - 2021	Member of Postdoc Committee	Public Community Engagement	Westlake University	-

Date	Event Name	Event Type	Institution	Country
2022 - 2022	2022 Exploration Australian Multidisciplinary Webinar	Conference	2022 Australian Australian Multidisciplinary Webinar	Australia

Review, Assessment, Editorial and Advice

Date	Title	Type	Institution	Country
2023 - ongoing	Aggregate	Journal Review	The University of Adelaide	-
2022 - ongoing	Examine MPhil thesis	Thesis Review	The University of Adelaide	Australia
2021 - ongoing	MethodsX	Journal Review	Westlake University	-

Email: yue.hui@adelaide.edu.au

Yue Hui

Appointments

Language Competencies

Education

Research Interests

Journals

Theses

Preprint

Current Higher Degree by Research Supervision (University of Adelaide)

Mentoring

Memberships

Community Engagement

Event Participation

Review, Assessment, Editorial and Advice

Connect With Me

External Profiles

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