Yoshi Tan

Preterm birth remains the leading cause of neonatal mortality and morbidity worldwide. Mothers at risk are routinely given antenatal corticosteroids to promote maturation of fetal organs, reducing the incidence of neonatal respiratory distress syndrome and other complications. However, infants have variable responsiveness to treatment and, despite over five decades of clinical use, there is limited understanding of the underlying mechanisms.

My PhD uses a preclinical model of preterm birth to investigate the molecular factors that contribute to the diverse range of responses to ACS.