Yiru Shi
South Australian Immunogenomics Cancer Institute
Faculty of Health and Medical Sciences
Dr. Yiru Shi obtained her Master of Science in Biotechnology from the University of Queensland in 2019 and earned her PhD in 2025 from Australian Institute of Bioengineering (AIBN), University of Queensland. She is currently a postdoctoral researcher at the South Australian immunoGENomics Cancer Institute (SAiGENCI), the University of Adelaide. Shi is committed to developing innovative in situ vaccine strategies for cancer immunotherapy.
During her PhD, Yiru focused on engineering smart nano- and biomaterials to stimulate robust antitumor immune responses within the tumor microenvironment. Her research emphasized the design of nanoparticles combined with oncolytic peptides to promote immunogenic cell death and enhance immune activation. This work led to the development of a multifunctional in situ cancer vaccine platform that demonstrated potent systemic antitumor immunity in preclinical models.
Dr. Shi joined SAiGENCI to continue her work on next-generation in situ vaccines for cancer immunotherapy. Her interdisciplinary approach integrates rational biomaterial design with immune engineering to address critical challenges in the treatment of solid tumors.
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Appointments
Date Position Institution name 2025 - ongoing Postdoctoral Researcher University of Adelaide -
Education
Date Institution name Country Title 2021 - 2025 University of Queensland Australia PhD 2018 - 2019 University of Queensland Australia MSc
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Journals
Year Citation 2025 Xian, H., Song, Y., Qu, J., Shi, Y., Zhang, Y., Wu, W., . . . Yu, C. (2025). CaClOH-Modified Silica Nanoparticles for mRNA Delivery. Nano Letters, 25(16), 6365-6373.
Scopus12024 Yang, Y., Chen, S., Zhang, M., Shi, Y., Luo, J., Huang, Y., . . . Yu, C. (2024). Mesoporous nanoperforators as membranolytic agents via nano- and molecular-scale multi-patterning.. Nat Commun, 15(1), 1891.
Scopus2 Europe PMC22023 Shi, Y., Dai, Z., Wang, Y., Luo, J., Cai, L., Tang, J., . . . Yang, Y. (2023). Engineering Crystallinity Gradients for Tailored CaO₂ Nanostructures: Enabling Alkalinity-Reinforced Anticancer Activity with Minimized Ca²⁺/H₂O₂ Production. Nano letters, 23(23), 10657-10666.
Scopus32020 Wang, Y., Yang, Y., Shi, Y., Song, H., & Yu, C. (2020). Antibiotic-Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives. Advanced Materials, 32(18), 1-21.
Scopus672 WoS396 Europe PMC2282020 Shi, Y., Fu, J., & Yang, Y. (2020). Effects of synthetic routes on the compositional and structural properties of dendritic mesoporous organosilica nanoparticles: The unexpected reversed “double-edged sword” role of reaction time. Microporous and Mesoporous Materials, 294, 1-8.
Scopus6 WoS4
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