Dr Yiru Shi
Grant-Funded Researcher (A)
SAIGENCI
College of Health
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr. Yiru Shi obtained her Master of Science in Biotechnology from the University of Queensland in 2019 and earned her PhD in 2025 from Australian Institute of Bioengineering (AIBN), University of Queensland. She is currently a postdoctoral researcher at the South Australian immunoGENomics Cancer Institute (SAiGENCI), the University of Adelaide. Shi is committed to developing innovative in situ vaccine strategies for cancer immunotherapy.During her PhD, Yiru focused on engineering smart nano- and biomaterials to stimulate robust antitumor immune responses within the tumor microenvironment. Her research emphasized the design of nanoparticles combined with oncolytic peptides to promote immunogenic cell death and enhance immune activation. This work led to the development of a multifunctional in situ cancer vaccine platform that demonstrated potent systemic antitumor immunity in preclinical models.Dr. Shi joined SAiGENCI to continue her work on next-generation in situ vaccines for cancer immunotherapy. Her interdisciplinary approach integrates rational biomaterial design with immune engineering to address critical challenges in the treatment of solid tumors.
| Date | Position | Institution name |
|---|---|---|
| 2025 - ongoing | Postdoctoral Researcher | University of Adelaide |
| Date | Institution name | Country | Title |
|---|---|---|---|
| 2021 - 2025 | University of Queensland | Australia | PhD |
| 2018 - 2019 | University of Queensland | Australia | MSc |
| Year | Citation |
|---|---|
| 2026 | Dai, Z., Wang, Q., Zhang, M., Shi, Y., Yang, Y., Song, H., . . . Yu, C. (2026). Tumor-activated nanocomplex reprograms cancer and macrophage metabolism in opposite directions to overcome immune suppression. Biomaterials, 326, 12 pages. |
| 2025 | Lin, N., Shi, Y., Xia, Y., Yang, Y., & Hua, R. (2025). Risk Factors for Histologic Chorioamnionitis Among Women with Prenatal Fever During Preterm Delivery: A Retrospective Cohort Study. INTERNATIONAL JOURNAL OF WOMENS HEALTH, 17, 3777-3788. |
| 2025 | Xian, H., Song, Y., Qu, J., Shi, Y., Zhang, Y., Wu, W., . . . Yu, C. (2025). CaClOH-Modified Silica Nanoparticles for mRNA Delivery. Nano Letters, 25(16), 6365-6373. Scopus1 WoS1 Europe PMC1 |
| 2025 | Shi, Y., Hou, Y., Mabrouk, M. T., Yu, C., & Yang, Y. (2025). In Situ Vaccines in the Era of Cancer Immunotherapy: Conceptual Innovation and Clinical Translation. Advanced Science, 12(37), 23 pages. Scopus2 WoS2 Europe PMC1 |
| 2025 | Luo, J., Wang, Y., Dai, Z., Shi, Y., Wu, W., Qu, J., . . . Yang, Y. (2025). Passivation-Engineered Zinc Peroxide Nanoparticles as Th1-Biased Adjuvant for Antitumor Immunity. Small, 21(42), e05250-1-e05250-14. |
| 2024 | Yang, Y., Chen, S., Zhang, M., Shi, Y., Luo, J., Huang, Y., . . . Yu, C. (2024). Mesoporous nanoperforators as membranolytic agents via nano- and molecular-scale multi-patterning.. Nat Commun, 15(1), 1891. Scopus2 WoS2 Europe PMC2 |
| 2023 | Shi, Y., Dai, Z., Wang, Y., Luo, J., Cai, L., Tang, J., . . . Yang, Y. (2023). Engineering Crystallinity Gradients for Tailored CaO₂ Nanostructures: Enabling Alkalinity-Reinforced Anticancer Activity with Minimized Ca²⁺/H₂O₂ Production. Nano letters, 23(23), 10657-10666. Scopus5 WoS5 Europe PMC2 |
| 2020 | Wang, Y., Yang, Y., Shi, Y., Song, H., & Yu, C. (2020). Antibiotic-Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives. Advanced Materials, 32(18), 1-21. Scopus711 WoS701 Europe PMC304 |
| 2020 | Shi, Y., Fu, J., & Yang, Y. (2020). Effects of synthetic routes on the compositional and structural properties of dendritic mesoporous organosilica nanoparticles: The unexpected reversed “double-edged sword” role of reaction time. Microporous and Mesoporous Materials, 294, 1-8. Scopus6 WoS5 |
| Year | Citation |
|---|---|
| - | Shi, Y. (n.d.). Development of calcium-based nanoparticles for in situ vaccines. |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2025 | Co-Supervisor | Bioengineered Therapeutic Platforms for Cancer Immunotherapy | Doctor of Philosophy | Doctorate | Full Time | Miss Yuxuan Hou |
| 2025 | Co-Supervisor | Bioengineered Therapeutic Platforms for Cancer Immunotherapy | Doctor of Philosophy | Doctorate | Full Time | Miss Yuxuan Hou |
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