Yeesim Khew-Goodall

Research Interests

Cancer Cell Biology Cancer Therapy Chemotherapy Developmental Biology Drug discovery Cancer Biology and Clinical Oncology Innovative Therapeutics Translational Health Outcomes

Dr Yeesim Khew-Goodall

Centre for Cancer Biology

College of Health

I lead the Cell Signalling Laboratory at the Centre for Cancer Biology, a joint initiative of SA Pathology and the University of South Australia. Our team collaborates nationally and internationally, integrating advanced technologies such as phosphoproteomics, spatial transcriptomics, and high-resolution imaging with patient-derived and iPSC-based models.
Lab Mission and Impact
Our mission is to decode the signalling networks that drive cancer progression and therapy resistance, translating these discoveries into new biomarkers and therapeutic strategies for aggressive cancers. Through innovation and collaboration, we aim to improve outcomes for patients with cancers that currently lack effective targeted treatments.
I pioneered studies on epithelial–mesenchymal transition (EMT), making foundational contributions to understanding cell plasticity through microRNA regulation and phosphorylation-mediated signalling. Today, my research focuses on dysregulated signalling networks driving tumour growth, metastasis, and therapy resistance, particularly in cancers lacking targeted therapies, such as triple-negative breast cancer (TNBC) and neuroblastoma. More recently, my work on neuroblastoma has brought me full circle to my early interest in neuronal differentiation—now exploring how developmental programs can give rise to cancers that originate in the womb.
My Journey. After completing a B.Sc. (Honours) at the University of Adelaide, I earned a Ph.D. in enzymology and protein chemistry. My postdoctoral training began at the Roche Institute of Molecular Biology (USA), where I applied emerging molecular biology techniques to identify marker genes involved in olfactory neuron regeneration and differentiation. A second postdoctoral fellowship at the Friedrich Miescher Institute (Switzerland) sparked my enduring interest in cancer signalling networks.
Returning to Adelaide with a young family, I joined the Hanson Centre for Cancer Research (later the Hanson Institute, now part of SA Pathology). In 2006, I was awarded a Cancer Council SA Senior Fellowship, which solidified my commitment to cancer research.

Research Vision and Impact

Our research aims to uncover the molecular and cellular mechanisms that drive cancer progression and therapy resistance, with a focus on translating these insights into improved treatment strategies. By integrating cutting-edge technologies and collaborative approaches, we strive to identify novel therapeutic targets and biomarkers that can ultimately improve patient outcomes in aggressive cancers such as triple-negative breast cancer and neuroblastoma that currrently lack effective targeted therapy.

Current Research Projects

Triple-Negative Breast Cancer

Our research focuses on understanding key signalling pathways that drive triple-negative breast cancer (TNBC) progression and treatment response. Current projects include:

Investigating how specific pathways influence TNBC response to existing therapies, including their role in determining cancer cell fate and shaping the tumour microenvironment.Identifying the molecular mechanisms underlying these pathways, such as kinase substrates and novel roles of post-translational modifications in regulating kinase function.Exploring how dysregulation of endosomal trafficking contributes to cancer progression.To address these questions, our laboratory employs cutting-edge approaches including phosphoproteomics, functional genomics, spatial transcriptomics, high/super-resolution confocal microscopy, genetically engineered and xenograft mouse models of TNBC, and analyses of patient-derived breast cancer specimens.

• Investigating pathways influencing treatment response and tumour microenvironment

• Identifying kinase substrates and novel roles of post-translational modifications

• Exploring how dysregulated endosomal trafficking drives cancer progression

Neuroblastoma

Our neuroblastoma research aims to uncover critical signalling pathways involved in neuroblast differentiation and maturation, and how their dysregulation leads to tumour development. Current projects include:

Using induced pluripotent stem cells (iPSCs) to study the differentiation of neuroblasts into sympathetic neurons and identify key signalling programs.Leveraging insights from neuroblast differentiation to understand how aberrant signalling drives neuroblastoma.Developing iPSC-based disease models to discover and validate potential therapeutic targets.These studies integrate advanced sequencing technologies for coding and non-coding RNAs, bioinformatics, and spatial transcriptomics, using both mouse embryos and patient samples. This work is part of a collaborative effort with Professor Quenten Schwarz and Professor Greg Goodall at the Centre for Cancer Biology.

• Using iPSC models to study neuroblast differentiation and maturation

• Identifying dysregulated signalling pathways that lead to neuroblastoma

• Developing disease models to discover new therapeutic targets

Cell Signalling Laboratory, Centre for Cancer Biology

Date Position Institution name
2013 - ongoing Adjunct Professor University of South Australia
2005 - ongoing Affiliate Titleholder University of Adelaide
1990 - ongoing Medical Scientist (Research) SA Pathology

Date Institution name Country Title
University of Adelaide Australia PhD
University of Adelaide Australia B Sc (Hons)

Date Title Institution Country
Postdoctoral Fellow Roche Institute of Molecular Biology United States
Postdoctoral Fellow Friedrich Miescher Institute Switzerland

Year Citation
2024 Thompson, E. J., Escarbe, S., Tvorogov, D., Farshid, G., Gregory, P. A., Khew-Goodall, Y., . . . Bonder, C. S. (2024). Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis. Growth Factors, 42(2), 49-61.
DOI Scopus2 WoS2 Europe PMC1
2023 Orang, A., Dredge, B. K., Liu, C. Y., Bracken, J. M., Chen, C. -H., Sourdin, L., . . . Bracken, C. P. (2023). Basonuclin-2 regulates extracellular matrix production and degradation. Life Science Alliance, 6(10), e202301984-1-e202301984-17.
DOI Scopus3 WoS3 Europe PMC7
2022 Onglao, W., Khew-Goodall, Y., Belle, L., & Lonic, A. (2022). Aberrant post-translational modifications in endosomal trafficking are potential therapeutic targets to avert therapy resistance in solid cancers: Dysregulation of PTM-regulated endosomal interactions presents an opportunity to block oncogenic signalling from multiple receptors by targeting common trafficking pathways. BioEssays, 44(2), 2100192-1-2100192-9.
DOI Scopus2 WoS3 Europe PMC3
2022 Lonic, A., Onglao, W., & Khew-Goodall, Y. (2022). Quantifying EGFR endosomal recycling via immunofluorescence in breast cancer cells. STAR Protocols, 3(2), 101305-1-101305-12.
DOI Scopus2 WoS2 Europe PMC2
2021 Lonic, A., Gehling, F., Belle, L., Li, X., Schieber, N. L., Nguyen, E. V., . . . Khew-Goodall, Y. (2021). Phosphorylation of PKCδ by FER tips the balance from EGFR degradation to recycling. Journal of Cellular Biochemistry, 220(2), 1-27.
DOI Scopus23 WoS22 Europe PMC23
2021 Manning, J. A., Shah, S. S., Nikolic, A., Henshall, T. L., Khew-Goodall, Y., & Kumar, S. (2021). The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease. Cell Death and Disease, 12(4), 398-1-398-16.
DOI Scopus19 WoS18 Europe PMC14
2021 Yang, J., Antin, P., Berx, G., Blanpain, C., Brabletz, T., Bronner, M., . . . Sheng, G. (2021). Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition (Nature Reviews Molecular Cell Biology, (2020), 21, 6, (341-352), 10.1038/s41580-020-0237-9). Nature Reviews Molecular Cell Biology, 22(12), 834.
DOI Scopus16 Europe PMC20
2020 Po uha, S. T., Le Grand, M., Brandl, M. B., Gifford, A. J., Goodall, G. J., Khew-Goodall, Y., & Kavallaris, M. (2020). Stathmin levels alter PTPN14 expression and impact neuroblastoma cell migration. British Journal of Cancer, 122(3), 434-444.
DOI Scopus9 WoS9 Europe PMC8
2020 Yang, J., Antin, P., Berx, G., Blanpain, C., Goodall, G. J., Khew Goodall, Y., & Sheng, G. (2020). Guidelines and definitions for research on epithelial-mesenchymal transition. Nature Reviews Molecular Cell Biology, 21(6), 341-352.
DOI Scopus1611 WoS1447 Europe PMC1543
2019 Bottini, A., Wu, D. J., Ai, R., Le Roux, M., Lonic, A., Li, X., . . . Bottini, N. (2019). PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes. Annals of the rheumatic diseases, 78(5), 600-609.
DOI Scopus55 WoS53 Europe PMC56
2018 Pillman, K. A., Phillips, C. A., Roslan, S., Toubia, J., Dredge, B. K., Bert, A. G., . . . Gregory, P. A. (2018). miR-200/375 control epithelial plasticity-associated alternative splicing by repressing the RNA-binding protein Quaking. EMBO Journal, 37(13), 20 pages.
DOI Scopus90 WoS88 Europe PMC79
2015 Belle, L., Ali, N., Lonic, A., Li, X., Paltridge, J., Roslan, S., . . . Khew-Goodall, Y. (2015). The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking. Science Signaling, 8(364), ra18-1-ra18-12.
DOI Scopus54 WoS53 Europe PMC49
2015 Bracken, C., Khew-Goodall, Y., & Goodall, G. (2015). Network-based approaches to understand the roles of miR-200 and other micrornas in cancer. Cancer Research, 75(13), 2594-2599.
DOI Scopus50 WoS50 Europe PMC45
2014 Bracken, C. P., Li, X., Wright, J. A., Lawrence, D., Pillman, K. A., Salmanidis, M., . . . Goodall, G. (2014). Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion. The EMBO Journal, 33(18), 1979-2134.
DOI Scopus124 WoS121 Europe PMC114
2014 Li, X., Roslan, S., Johnstone, C., Wright, J., Bracken, C., Anderson, M., . . . Khew-Goodall, Y. (2014). MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways. Oncogene, 33(31), 4077-4088.
DOI Scopus109 WoS103 Europe PMC102
2013 Paltridge, J., Belle, L., & Khew-Goodall, Y. (2013). The secretome in cancer progression. BBA - Proteins and Proteomics, 1834(11), 2233-2241.
DOI Scopus123 WoS120 Europe PMC113
2013 Attema, J., Bert, A., Lim, Y., Kolesnikoff, N., Lawrence, D., Pillman, K., . . . Goodall, G. (2013). Identification of an enhancer that increases miR-200b~200a~429 gene expression in breast cancer cells. PLoS One, 8(9), 1-15.
DOI Scopus21 WoS19 Europe PMC19
2013 Lim, Y., Wright, J., Attema, J., Gregory, P., Bert, A., Smith, E., . . . Goodall, G. (2013). Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state. Journal of Cell Science, 126(10), 2256-2266.
DOI Scopus173 WoS157 Europe PMC153
2013 Paterson, E., Kazenwadel, J., Bert, A., Khew-Goodall, Y., Ruszkiewicz, A., & Goodall, G. (2013). Down-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression. Neoplasia, 15(2), 180-191.
DOI Scopus150 WoS140 Europe PMC127
2013 Hauschild, N., Belle, L., & Khew Goodall, Y. (2013). PTPN14 (protein tyrosine phosphatase, non-receptor type 14). Atlas of genetics and cytogenetics in oncology and haematology, 17(7), 462-466.
DOI
2012 Khew-Goodall, Y., & Goodall, G. (2012). A microRNA that limits metastatic colonisation and endothelial recruitment. EMBO Journal, 31(4), 786-787.
DOI Scopus7 WoS6 Europe PMC5
2012 Khew-Goodall, Y., & Goodall, G. (2012). Stromal miR-320 keeps an oncogenic secretome in check. Nature Cell Biology, 14(2), 124-125.
DOI Scopus14 WoS12 Europe PMC12
2011 Gregory, P., Bracken, C., Smith, E., Bert, A., Wright, J., Roslan, S., . . . Goodall, G. (2011). An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Molecular Biology of the Cell, 22(10), 1686-1698.
DOI Scopus510 WoS478 Europe PMC461
2010 Williams, S., Milne, I., Bagley, C., Gamble, J., Vadas, M., Pitson, S., & Khew-Goodall, Y. (2010). A proinflammatory role for proteolytically cleaved annexin A1 in neutrophil transendothelial migration. Journal of Immunology, 185(5), 3057-3063.
DOI Scopus77 WoS73 Europe PMC66
2010 Khew-Goodall, Y., & Goodall, G. (2010). Myc-modulated miR-9 makes more metastases. Nature Cell Biology, 12(3), 209-211.
DOI Scopus102 WoS99 Europe PMC89
2009 Bracken, C., Gregory, P., Khew-Goodall, Y., & Goodall, G. (2009). The role of microRNAs in metastasis and epithelial-mesenchymal transition. Cellular and Molecular Life Sciences, 66(10), 1682-1699.
DOI Scopus107 WoS96 Europe PMC90
2008 Barr, R., Lynn, H., Moretti, P., Khew-Goodall, Y., & Pitson, S. (2008). Deactivation of Sphingosine Kinase 1 by Protein Phosphatase 2A. Journal of Biological Chemistry, 283(50), 34994-35002.
DOI Scopus51 WoS43 Europe PMC42
2008 Paterson, E., Kolesnikoff, N., Gregory, P., Bert, A., Khew-Goodall, Y., & Goodall, G. (2008). The microRNA-200 Family Regulates Epithelial to Mesenchymal Transition. The Scientific World Journal, 8, 901-904.
DOI Scopus76 WoS72 Europe PMC61
2008 Belle, L., & Khew-Goodall, Y. (2008). PTP-Pez: A novel regulator of TGF beta signaling. Cell Cycle, 7(15), 2290-2295.
DOI Scopus15 WoS13 Europe PMC10
2008 Gregory, P., Bert, A., Paterson, E., Barry, S., Tsykin, A., Farshid, G., . . . Goodall, G. (2008). The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nature Cell Biology, 10(5), 593-601.
DOI Scopus3457 WoS3254 Europe PMC2975
2007 Belle, L., Wadham, C., Crocker, L., Lardelli, M., & Khew-Goodall, Y. (2007). The protein tyrosine phosphatase Pez regulates TGFβ, epithelial–mesenchymal transition, and organ development. Journal of Cell Biology, 178(7), 1223-1235.
DOI Scopus75 WoS71 Europe PMC63
2005 Khew-Goodall, Y., & Wadham, C. (2005). A perspective on regulation of cell-cell adhesion and epithelial-mesenchymal transition: Known and novel. Cells Tissues Organs, 179(1-2), 81-86.
DOI Scopus19 WoS16 Europe PMC15
2003 Stein, B., Gamble, J., Pitson, S., Vadas, M., & Khew-Goodall, Y. (2003). Activation of endothelial extracellular signal-regulated kinase is essential for neutrophil transmigration: Potential involvement of a soluble neutrophil factor in endothelial activation. Journal of Immunology, 171(11), 6097-6104.
DOI Scopus27 WoS25 Europe PMC21
2003 Wadham, C., Gamble, J., Vadas, M., & Khew-Goodall, Y. (2003). The protein tyrosine phosphatase pez is a major phosphatase of adherens junctions and dephosphorylates b-catenin. Molecular Biology of the Cell, 14(6), 2520-2529.
DOI Scopus82 WoS78 Europe PMC74
2002 Jitrapakdee, S., Nezic, M., Cassady, A., Khew-Goodall, Y., & Wallace, J. (2002). Molecular cloning and domain structure of chicken pyruvate carboxylase. Biochemical and Biophysical Research Communications, 295(2), 387-393.
DOI Scopus6 WoS6 Europe PMC3
2000 Wadham, C., Gamble, J., Vadas, M., & Khew-Goodall, Y. (2000). Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation. Journal of Cell Science, 113(17), 3117-3123.
DOI Scopus42 WoS42 Europe PMC38
1999 Khew-Goodall, Y., Wadham, C., Stein, B., Gamble, J., & Vadas, M. (1999). Stat6 activation is essential for interleukin-4 induction of P-selectin transcription in juman umbilical vein endothelial cells. Arteriosclerosis, Thrombosis and Vascular Biology, 19(6), 1421-1429.
DOI Scopus52 WoS46 Europe PMC35
1998 Xia, P., Gamble, J., Rye, K. A., Wang, L., Hii, C., Cockerill, P., . . . Vadas, M. (1998). Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway. Proceedings of the National Academy of Sciences of the United States of America, 95(24), 14196-14201.
DOI Scopus379 WoS360 Europe PMC331
1998 Isenmann, S., Khew-Goodall, Y., Gamble, J., Vadas, M., & Wattenberg, B. (1998). A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal. Molecular Biology of the Cell, 9(7), 1649-1660.
DOI Scopus114 WoS113 Europe PMC104
1996 Khew-Goodall, Y., Butcher, C. M., Litwin, M. S., Newlands, S., Korpelainen, E. I., Noack, L. M., . . . Vadas, M. A. (1996). Chronic expression of P-selectin on endothelial cells stimulated by the T-Cell cytokine, interleukin-3. Blood, 87(4), 1432-1438.
DOI Scopus85 WoS75 Europe PMC51
1996 Smith, W. B., Noack, L., Khew-Goodall, Y., Isenmann, S., Vadas, M. A., & Gamble, J. R. (1996). Transforming growth factor-β1 inhibits the production of IL-8 and the transmigration of neutrophils through activated endothelium. Journal of Immunology, 157(1), 360-368.
DOI Scopus146 WoS121 Europe PMC93
1994 Vadas, M., Lopez, A., Gamble, J., Khew-Goodall, Y., Smith, W., Bernard, C., . . . Hercus, T. (1994). Cytokines and allergy. Journal of Allergy and Clinical Immunology, 94(6 PART 2), 1289-1293.
DOI Scopus13 WoS12 Europe PMC11
1993 Gamble, J. R., Khew-Goodall, Y., & Vadas, M. A. (1993). Transforming Growth Factor-β Inhibits E-Selectin Expression on Human Endothelial Cells. Journal of Immunology, 150(10), 4494-4503.
DOI Scopus204 WoS198 Europe PMC114
1993 Khew-Goodall, Y., Gamble, J. R., & Vadas, M. A. (1993). Regulation of adhesion and adhesion molecules in endothelium by transforming growth factor-β. Current Topics in Microbiology and Immunology, 184, 187-199.
DOI Scopus8 Europe PMC2
1991 Khew-Goodall, Y., Mayer, R. E., Maurer, F., Stone, S. R., & Hemmings, B. A. (1991). Structure and Transcriptional Regulation of Protein Phosphatase 2A Catalytic Subunit Genes. Biochemistry, 30(1), 89-97.
DOI Scopus92 WoS92 Europe PMC73
1991 Khew-Goodall, Y., Grillo, M., Getchell, M. L., Danho, W., Getchell, T. V., & Margolis, F. L. (1991). Vomeromodulin, a putative pheromone transporter: Cloning, characterization, and cellular localization of a novel glycoprotein of lateral nasal gland. FASEB Journal, 5(14), 2976-2982.
DOI Scopus52 WoS53 Europe PMC39
1991 Biffo, S., Goren, T., Khew-Goodall, Y. S., Miara, J., & Margolis, F. L. (1991). Expression of calmodulin mRNA in rat olfactory neuroepithelium. Molecular Brain Research, 10(1), 13-21.
DOI Scopus23 WoS26 Europe PMC20
1991 Khew-Goodall, Y., Mayer, R. E., Maurer, F., Stone, S. R., & Hemmings, B. A. (1991). Correction: Structure and Transcriptional Regulation of Protein Phosphatase 2A Catalytic Subunit Genes (Biochemistry (1991) 30(1) (89–97) (10.1021/bi00215a014)). Biochemistry, 30(21), 5328.
DOI Scopus1 WoS5
1991 Khew-Goodall, Y. S., Johannssen, W., Attwood, P. V., Wallace, J. C., & Keech, D. B. (1991). Studies on dilution inactivation of sheep liver pyruvate carboxylase. Archives of Biochemistry and Biophysics, 284(1), 98-105.
DOI Scopus21 WoS22 Europe PMC15
1990 Mayer, R. E., Khew-Goodall, Y., Stone, S. R., & Hemmings, B. A. (1990). Expression and organization of protein phosphatase 2A catalytic subunit genes.. Advances in Second Messenger and Phosphoprotein Research, 24, 236-241.
Scopus7 Europe PMC5
1990 Verhaagen, J., Oestreicher, A. B., Grillo, M., Khew‐Goodall, Y., Gispen, W. H., & Margolis, F. L. (1990). Neuroplasticity in the olfactory system: Differential effects of central and peripheral lesions of the primary olfactory pathway on the expression of B‐50/GAP43 and the olfactory marker protein. Journal of Neuroscience Research, 26(1), 31-44.
DOI Scopus190 WoS192 Europe PMC156
1988 Khew-Goodall, Y., & Hemmings, B. A. (1988). Tissue-specific expression of mRNAs encoding α- and β-catalytic subunits of protein phosphatase 2A. FEBS Letters, 238(2), 265-268.
DOI Scopus92 WoS93 Europe PMC77
1987 Rogers, K. E., Dasgupta, P., Gubler, U., Grillo, M., Khew-Goodall, Y. S., & Margolis, F. L. (1987). Molecular cloning and sequencing of a cDNA for olfactory marker protein. Proceedings of the National Academy of Sciences of the United States of America, 84(6), 1704-1708.
DOI Scopus79 WoS79 Europe PMC48

Year Citation
2018 Bottini, A., Wu, D. J., Ai, R., LeRoux, M., Bartok, B., Bombardieri, M., . . . Bottini, N. (2018). Non-Receptor Protein Tyrosine Phosphatase 14 (PTPN14) Promotes YAP-Dependent Tgfbeta Signaling in RA FLS. In ARTHRITIS & RHEUMATOLOGY Vol. 70 (pp. 1 page). IL, Chicago: WILEY.

Year Citation
2015 Hissaria, P., Bert, A., Proudman, S., Goodall, G., & Khew-Goodall, Y. (2015). DIFFERENTIAL PATTERN OF MICRORNA EXPRESSION IN LIMITED AND DIFFUSE CUTANEOUS VARIANTS OF SYSTEMIC SCLEROSIS - A POSSIBLE MECHANISM TO EXPLAIN THE UNIQUE CLINICAL PHENOTYPES. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL.
2015 Hissaria, P., Bert, A., Proudman, S., Goodall, G., & Khew-Goodall, Y. (2015). MICRO RNAS (MIRNAS) INVOLVED IN TGF BETA SIGNALLING PATHWAYS ARE DIFFERENTIALLY EXPRESSED IN THE PAPILLARY DERMIS OF INVOLVED SKIN IN LIMITED AND DIFFUSE CUTANEOUS SCLERODERMA PATIENTS. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL.
2013 Khew-Goodall, Y. (2013). A NOVEL REGULATOR OF THE SECRETOME MODULATES CANCER METASTASIS. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. Hangzhou, PEOPLES R CHINA: WILEY-BLACKWELL.
2010 Crocker, L., Gregory, P., Goodall, G., & Khew-Goodall, Y. (2010). MICRORNAS REGULATING FIBROBLAST ACTIVATION AND EPITHELIAL MESENCHYMAL TRANSITION IN FIBROSIS. Poster session presented at the meeting of WOUND REPAIR AND REGENERATION. WILEY-BLACKWELL.
2008 Gregory, P. A., Bracken, C. P., Bert, A. G., Paterson, E. L., Kolesnikoff, N., Farshid, G., . . . Goodall, G. J. (2008). Role of the miR-200 family in mediating EMT in response to TGF-β. Poster session presented at the meeting of Abstracts and Reviews of 7th Joint Conference of the International Cytokine Society and the International Society for Interferon and Cytokine Research, as published in Cytokine. Montreal, Canada: Elsevier.
DOI

  • Trafficking mechanisms governing receptor availability for signalling, NHMRC - Project Grant, 01/01/2018 - 31/12/2021

  • Using miR-200 to find new therapeutic targets for neuroblastoma, NHMRC - Project Grant, 01/01/2017 - 31/12/2019

Date Role Research Topic Program Degree Type Student Load Student Name
2020 Principal Supervisor Identifying pY374-PKC-delta substrates that control endosomal trafficking of receptor tyrosine kinases Doctor of Philosophy Doctorate Full Time Winona Faye Sivan

Date Role Research Topic Program Degree Type Student Load Student Name
2010 - 2012 Co-Supervisor The miR 200 Family is Controlled by Epigenetic based Mechanisms and Mediates Transition Between Non Stem and Stem like Cell Phenotypes Doctor of Philosophy Doctorate Full Time Mr Yat Yuen Lim
2006 - 2011 Principal Supervisor Tyrosine Phosphatase Pez: A Novel Regulator of TGFß Signalling, Epithelial-Mesenchymal Transition and Protein Secretion in Development and Cancer Doctor of Philosophy Doctorate Full Time Mrs Leila Belle
2006 - 2010 Co-Supervisor Downregulation of the MicroRNA-200 Family Induces Epithelial to Mesenchymal Transition Doctor of Philosophy Doctorate Full Time Miss Emily Paterson
2004 - 2009 Principal Supervisor A Novel Proinflammatory Role for Annexin A1 in Neutrophil Transendothelial Migration Doctor of Philosophy Doctorate Full Time Ms Samantha Louise Williams
1998 - 2003 Principal Supervisor Protein Tyrosine Phosphatase Pez: Its role in the regulation of cell-cell adhesions Doctor of Philosophy Doctorate Full Time Ms Carol Wadham

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