Prof Xin-Fu Zhou

School of Pharmacy and Biomedical Sciences

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Available For Media Comment.


This laboratory has a long standing interest in neurotrophins and their receptors in neural development and neurological disorders. In recent years, we are interested in how neurotrophins and their receptors signal in the neurodegenerative disease such as Alzheimer’s disease. BDNF is one of the most studied neurotrophins which is critical for brain functions such as learning and memory. Its precursor has a different role to that of mature BDNF. We have been investigating its role in spinal cord injury, in pain and in nerve development. Neurotrophins can be potential drugs for the treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases or nerve injuries including spinal cord injury and stroke.
We are also interested in developing methods to treat neurological diseases. We use a variety of techniques including biochemical, immunological, molecular and histological approaches in our research projects. The research activities are funded by NHMRC, ARC, UniSA and other funding agencies.
Currently, the lab has running 3 NHMRC grants and 1 ARC grant.
The laboratory is interested to take honours, Msc and PhD students. It has been successful in educating honours students, Msc students and PhD students. The graduates of honours and MScs are 100% either employed, or go to medicine training or PhD training. This lab has educated over a dozen PhD graduates who are all leaders in the academics and administraters in different parts of the world. There are a number of honours, Msc and PhD research projects available and Scholarships which support the high degree students.
Investigators: Xin-Fu Zhou, MSc, PhD Miao Yang, MBBS, PhD Yanchuang Han PhD Jianjun Lu, MBBS, PhD Support Staff : Jin-Hua Zhong Hua Li Annie Sun, BMSc Yoon Lim, BMSc Visiting Scholars Willian Shan Liu Shangqing (Sandrich) Liu Students Ying Sun, MBBS, MSc, PhD student Yoon Lim MSc, PhD student Khalil Saadipour, Msc, PhD student

  • Neuroscience, neuron development, neurotrophins
  • spinal cord injury, nerve regeneration, neural plasticity
  • Neuropathic pain, affective pain and mechanisms
  • Neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease
  • Mood disorders, depression

Year Citation
2026 Xu, Y. X., Zhang, X. Y., Wang, L., Ma, H. C., Xue, S. Q., Gu, J. H., . . . Pu, L. J. (2026). Therapeutic potential of oral edaravone in diabetic endothelial dysfunction through NF-κB and p38 pathway inhibition. European Journal of Pharmacology, 1012, 178500.
DOI
2026 Yao, X. Q., Jiao, S. S., Saadipour, K., Zeng, F., Wang, Q. H., Zhu, C., . . . Wang, Y. J. (2026). Correction: p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer’s disease (Molecular Psychiatry, (2015), 20, 11, (1301-1310), 10.1038/mp.2015.49). Molecular Psychiatry, 31(2), 1202-1203.
DOI Europe PMC1
2025 Kelliny, S., Zhou, X. F., & Bobrovskaya, L. (2025). Alzheimer's disease and frontotemporal dementia: a review of pathophysiology and therapeutic approaches. Journal Of Neuroscience Research, 103(5, article no. e70046), 1-43.
DOI Scopus7 WoS6 Europe PMC5
2024 Lu, X. Y., Li, M. Q., Li, Y. T., Yao, J. Y., Zhang, L. X., Zeng, Z. H., . . . Li, F. (2024). Oral edaravone ameliorates behavioral deficits and pathologies in a valproic acid-induced rat model of autism spectrum disorder. Neuropharmacology, 258(110089), 1-13.
DOI Scopus3 WoS2
2024 Ma, Y. Y., Li, X., Yu, Z. Y., Luo, T., Tan, C. R., Bai, Y. D., . . . Wang, Y. J. (2024). Oral antioxidant edaravone protects against cognitive deficits induced by chronic hypobaric hypoxia at high altitudes. Translational psychiatry, 14(1, article no. 415), 1-13.
DOI Scopus7 WoS7 Europe PMC6
2024 Yang, C. -R., Liang, R., Liu, Y., Meng, F. -J., Zhou, F., Zhang, X. -Y., . . . Zhou, X. -F. (2024). Upregulation of proBDNF/p75NTR signaling in immune cells and its correlation with inflammatory markers in patients with major depression.. The FASEB Journal, 38(1), e23312-1-e23312-18.
DOI Scopus12 WoS10 Europe PMC8
2024 Hu, Y., Sun, Y. F., Yuan, H., Liu, J., Chen, L., Liu, D. H., . . . Wang, T. H. (2024). Vof16-miR-185-5p-GAP43 network improves the outcomes following spinal cord injury via enhancing self-repair and promoting axonal growth. CNS Neuroscience and Therapeutics, 30(e14535), 1-21.
DOI Scopus9 WoS8 Europe PMC10
2024 Cade, S., Prestidge, C., Zhou, X. F., & Bobrovskaya, L. (2024). The effects of a bioavailable curcumin formulation on Alzheimer's disease pathologies: A potential risk for neuroinflammation. Ibrain, 10(4), 391-547.
DOI Scopus1 Europe PMC1
2024 Lian, Y., Jia, Y. J., Wong, J., Zhou, X. F., Song, W., Guo, J., . . . Wang, Y. J. (2024). Clarity on the blazing trail: clearing the way for amyloid-removing therapies for Alzheimer's disease. Molecular Psychiatry, 29(2), 297-305.
DOI Scopus14 WoS15 Europe PMC13
2023 Cade, S., Zhou, X. F., & Bobrovskaya, L. (2023). An imbalance in the pro/mature BDNF ratio occurs in multiple brain regions during normal ageing in wild-type mice. Journal Of Molecular Neuroscience, 73(6), 469-484.
DOI Scopus10 WoS9 Europe PMC8
2023 Herselman, M. F., Lin, L., Luo, S., Yamanaka, A., Zhou, X. F., & Bobrovskaya, L. (2023). Sex-Dependent Effects of Chronic Restraint Stress on Mood-Related Behaviours and Neurochemistry in Mice. International Journal of Molecular Sciences, 24(12), 10353-1-10353-19.
DOI Scopus11 WoS12 Europe PMC12
2023 Liu, J., van Beusekom, H., Le Bu, X., Chen, G., Zhou, X. F., & Wang, Y. J. (2023). Preserving cognitive function in patients with Alzheimer's disease: the Alzheimer's disease neuroprotection research initiative (ADNRI). Neuroprotection, 1(2), 84-98.
DOI Scopus20 WoS18 Europe PMC12
2022 Shen, W. Y., Luo, C., Hurtado, P. R., Liu, X. J., Luo, R. Y., Li, H., . . . Dai, R. P. (2022). Up-regulation of proBDNF/p75NTR signaling in antibody-secreting cells drives systemic lupus erythematosus. Science Advances, 8(3, article no. eabj2797), 1-14.
DOI Scopus22 WoS21 Europe PMC20
2022 Cade, S., Zhou, X. F., & Bobrovskaya, L. (2022). The role of brain-derived neurotrophic factor and the neurotrophin receptor p75NTR in age-related brain atrophy and the transition to Alzheimer's disease. Reviews in the Neurosciences, 33(5), 515-529.
DOI Scopus10 WoS9 Europe PMC12
2022 Liu, D., Rychkov, G., Hurtado, P., Luo, H. Y., Zhang, T., Bobrovskaya, L., & Zhou, X. F. (2022). Conversion of human fibroblasts into induced neural stem cells by small molecules. International Journal of Molecular Sciences, 23(3, article no. 1740), 1-12.
DOI Scopus5 WoS5 Europe PMC4
2022 Lin, L., Herselman, M. F., Zhou, X. F., & Bobrovskaya, L. (2022). Effects of corticosterone on BDNF expression and mood behaviours in mice. Physiology and Behavior, 247(113721), 113721-1-113721-9.
DOI Scopus31 WoS33 Europe PMC25
2022 Yang, C. R., Ding, H. J., Yu, M., Zhou, F. H., Han, C. Y., Liang, R., . . . Zhou, X. F. (2022). proBDNF/p75NTR promotes rheumatoid arthritis and inflammatory response by activating proinflammatory cytokines. The FASEB Journal, 36(3), e22180-1-e22180-21.
DOI Scopus19 WoS19 Europe PMC18
2022 Wang, L., Zeng, Y. Q., Gu, J. H., Song, R., Cang, P. H., Xu, Y. X., . . . Zhou, X. F. (2022). Novel oral edaravone attenuates diastolic dysfunction of diabetic cardiomyopathy by activating the Nrf2 signaling pathway. European Journal of Pharmacology, 920(174846), 1-12.
DOI Scopus16 WoS16 Europe PMC12
2022 Zhao, L. Q., Parikh, A., Xiong, Y. X., Ye, Q. Y., Ying, G., Zhou, X. F., & Luo, H. Y. (2022). Neuroprotection of oral edaravone on middle cerebral artery occlusion in rats. Neurotoxicity Research, 40(4), 995-1006.
DOI Scopus6 WoS5 Europe PMC4
2022 Xiong, J., Deng, I., Kelliny, S., Lin, L., Bobrovskaya, L., & Zhou, X. F. (2022). Long term high fat diet induces metabolic disorders and aggravates behavioral disorders and cognitive deficits in MAPT P301L transgenic mice. Metabolic Brain Disease, 37(6), 1941-1957.
DOI Scopus22 WoS20 Europe PMC20
2022 Deng, I., Garg, S., Zhou, X. F., & a Bobrovskaya, L. (2022). The effects of novel formulations of edaravone and curcumin in the mouse intrastriatal lipopolysaccharide model of Parkinson's disease. Frontiers in bioscience (Scholar edition), 14(2), 1-17.
DOI Scopus4 Europe PMC3
2022 Xiong, L. L., Chen, L., Deng, I. B., Zhou, X. F., & Wang, T. H. (2022). P75 neurotrophin receptor as a therapeutic target for drug development to treat neurological diseases. European Journal of Neuroscience, 56(8), 5299-5318.
DOI Scopus14 WoS13 Europe PMC12
2022 Herselman, M. F., Bailey, S., Deo, P., Zhou, X. -F., Gunn, K. M., & Bobrovskaya, L. (2022). The Effects of Walnuts and Academic Stress on Mental Health, General Well-Being and the Gut Microbiota in a Sample of University Students: A Randomised Clinical Trial.. Nutrients, 14(22), 4776.
DOI Scopus14 WoS12 Europe PMC8
2021 Kelliny, S., Bobrovskaya, L., Zhou, X. F., & Upton, R. (2021). Pharmacokinetic modelling of human recombinant protein, p75ECD-Fc: a novel therapeutic approach for treatment of Alzheimer’s disease, in serum and tissue of Sprague Dawley rats. European Journal of Drug Metabolism and Pharmacokinetics, 46(2), 235-248.
DOI Scopus2 WoS2 Europe PMC2
2021 Zidan, A. A., Perkins, G., Al Hawwas, M., Elhossiny, A., Yang, J., Bobrovskaya, L., . . . Hurtado, P. R. (2021). Urine stem cells are equipped to provide B cell survival signals. Stem Cells, 39(6), 803-818.
DOI Scopus7 WoS6 Europe PMC7
2021 Xiong, L. L., Chen, J., Du, R. L., Liu, J., Chen, Y. J., Al Hawwas, M., . . . Bai, X. (2021). Brain-derived neurotrophic factor and its related enzymes and receptors play important roles after hypoxic-ischemic brain damage. Neural Regeneration Research, 16(8), 1453-1459.
DOI Scopus33 WoS30 Europe PMC23
2021 Xiong, L. L., Tan, Y. X., Du, R. L., Peng, Y., Xue, L. L., Liu, J., . . . Zhou, X. F. (2021). Effect of sutellarin on neurogenesis in neonatal hypoxia-ischemia rat model: potential mechanisms of action. American Journal of Chinese Medicine, 49(3), 677-703.
DOI Scopus10 WoS7 Europe PMC9
2021 Zhou, X. F. (2021). ESCAPE-NA1 trial brings hope of neuroprotective drugs for acute ischemic stroke: highlights of the phase 3 clinical trial on nerinetide. Neuroscience Bulletin, 37(4), 579-581.
DOI Scopus18 WoS17 Europe PMC17
2021 Kelliny, S., Lin, L., Deng, I., Xiong, J., Zhou, F., Al-Hawwas, M., . . . Zhou, X. F. (2021). A new approach to model sporadic Alzheimer’s disease by intracerebroventricular streptozotocin injection in APP/PS1 mice. Molecular Neurobiology, 58(8), 3692-3711.
DOI Scopus19 WoS15 Europe PMC17
2021 Deng, I., Wiese, M. D., Zhou, X. F., & Bobrovskaya, L. (2021). The efficacy of systemic administration of lipopolysaccharide in modelling pre-motor Parkinson's disease in C57BL/6 mice. NeuroToxicology, 85, 254-264.
DOI Scopus17 WoS14 Europe PMC11
2021 Deng, I., Corrigan, F., Garg, S., Zhou, X. F., & Bobrovskaya, L. (2021). Further characterization of intrastriatal lipopolysaccharide model of parkinson’s disease in c57bl/6 mice. International Journal of Molecular Sciences, 22(14), 20 pages.
DOI Scopus13 WoS11 Europe PMC10
2021 Zhou, R., Chen, L. L., Yang, H., Li, L., Liu, J., Chen, L., . . . Zhou, H. D. (2021). Effect of high cholesterol regulation of lrp1 and rage on aβ transport across the blood-brain barrier in Alzheimer's disease. Current Alzheimer Research, 18(5), 428-442.
DOI Scopus36 WoS34 Europe PMC28
2021 Chen, L., Zhou, Y. P., Liu, H. Y., Gu, J. H., Zhou, X. F., & Yue Qin, Z. (2021). Long-term oral administration of hyperoside ameliorates AD-related neuropathology and improves cognitive impairment in APP/PS1 transgenic mice. Neurochemistry International, 151, article no. 105196, 1-7.
DOI Scopus25 WoS21 Europe PMC19
2021 Zhou, L., Niu, R. Z., Zhou, H. S., Wang, Z. M., Wang, F. L., Yang, X. X., . . . Xiong, L. L. (2021). CT imaging character of different brain regions in different ages of Diannan small-ear pigs. Ibrain, 7(2), 90-94.
DOI
2021 Kelliny, S., Xiong, J., Bobrovskaya, L., & Zhou, X. F. (2021). Preclinical validation of a novel oral Edaravone formulation for treatment of frontotemporal dementia. Neurotoxicity Research, 39(6), 1689-1707.
DOI Scopus4 WoS4 Europe PMC3
2021 Ma, W., Yang, J. W., Wang, X. B., Luo, T., Zhou, L., Lagares, A., . . . Li, L. Y. (2021). Negative regulation by proBDNF signaling of peripheral neurogenesis in the sensory ganglia of adult rats. Biomedicine and Pharmacotherapy, 144(article no. 112273), 1-14.
DOI Scopus5 WoS5 Europe PMC4
2021 Liu, D., Bobrovskaya, L., & Zhou, X. F. (2021). Cell therapy for neurological disorders: the perspective of promising cells. Biology, 10(11, article no. 1142), 1-23.
DOI Scopus19 WoS14 Europe PMC12
2021 Lin, L., Zhou, X. F., & Bobrovskaya, L. (2021). Blockage of p75NTR ameliorates depressive-like behaviours of mice under chronic unpredictable mild stress. Behavioural Brain Research, 396(112905), 1-5.
DOI Scopus10 WoS9 Europe PMC7
2021 Hu, Z. -L., Luo, C., Hurtado, P. R., Li, H., Wang, S., Hu, B., . . . Dai, R. -P. (2021). Brain-derived neurotrophic factor precursor in the immune system is a novel target for treating multiple sclerosis. Theranostics, 11(2), 715-730.
DOI Scopus31 WoS32 Europe PMC30
2021 Lin, L., Fu, X. Y., Zhou, X. F., Liu, D., Bobrovskaya, L., & Zhou, L. (2021). Analysis of blood mature BDNF and proBDNF in mood disorders with specific ELISA assays. Journal of Psychiatric Research, 133, 166-173.
DOI Scopus31 WoS28 Europe PMC26
2021 Zidan, A. A., Al Hawwas, M., Perkins, G. B., Mourad, G. M., Stapledon, C. J. M., Bobrovskaya, L., . . . Hurtado, P. R. (2021). Characterization of urine stem cell-derived extracellular vesicles reveals B cell stimulating cargo. International Journal of Molecular Sciences, 22(1), 1-21.
DOI Scopus21 WoS19 Europe PMC19
2021 Zeng, Y. Q., Gu, J. H., Chen, L., Zhang, T. T., & Zhou, X. F. (2021). Gastrodin as a multi-target protective compound reverses learning memory deficits and AD-like pathology in APP/PS1 transgenic mice. Journal of Functional Foods, 77(article no. 104324), 1-8.
DOI Scopus25 WoS20
2020 Xiong, L. L., Xue, L. L., Du, R. L., Zhou, H. L., Tan, Y. X., Ma, Z., . . . Wang, T. H. (2020). Vi4-miR-185-5p-Igfbp3 network protects the brain from neonatal hypoxic ischemic injury via promoting neuron survival and suppressing the cell apoptosis. Frontiers in Cell and Developmental Biology, 8(529544), 1-18.
DOI Scopus30 WoS25 Europe PMC26
2020 Rahman, M., Luo, H., Bobrovskaya, L., & Zhou, X. F. (2020). Neuroprotective effects of anti-proBDNF in a rat photothrombotic ischemic model. Neuroscience, 446, 261-270.
DOI Scopus3 WoS3 Europe PMC3
2020 Lin, L. Y., Kelliny, S., Liu, L. C., Al-Hawwas, M., Zhou, X. F., & Bobrovskaya, L. (2020). Peripheral proBDNF delivered by an AAV vector to the muscle triggers depression-like behaviours in mice. Neurotoxicity Research, 38(3), 626-639.
DOI Scopus8 WoS8 Europe PMC8
2020 Kelliny, S., Lam, H. Y., Parikh, A., Wang, Y. J., Bobrovskaya, L., Upton, R., & Zhou, X. F. (2020). Preclinical study of the pharmacokinetics of p75ECD-Fc, a novel human recombinant protein for treatment of Alzheimer’s disease, in Sprague Dawley rats. Current Drug Metabolism, 21(3), 235-244.
DOI Scopus8 WoS7 Europe PMC7
2020 Liu, D., Pavathuparambil Abdul Manaph, N., Al Hawwas, M., Bobrovskaya, L., Xiong, L. L., & Zhou, X. F. (2020). Coating materials for neural stem/progenitor cell culture and differentiation. Stem Cells and Development, 29(8), 463-474.
DOI Scopus28 WoS27 Europe PMC23
2020 Yang, C. R., Zhang, X. Y., Liu, Y., Du, J. Y., Liang, R., Yu, M., . . . Zhou, X. F. (2020). Antidepressant Drugs Correct the Imbalance Between proBDNF/p75NTR/Sortilin and Mature BDNF/TrkB in the Brain of Mice with Chronic Stress. Neurotoxicity Research, 37(1), 171-182.
DOI Scopus40 WoS38 Europe PMC33
2020 Shen, W. Y., Luo, C., Reinaldo Hurtado, P., Hurtado-Perez, E., Luo, R. Y., Hu, Z. L., . . . Dai, R. P. (2020). The regulatory role of ProBDNF in monocyte function: Implications in Stanford type-A aortic dissection disease. FASEB Journal, 34(2), 2541-2553.
DOI Scopus27 WoS27 Europe PMC26
2020 Liu, D., Rychkov, G., Al-Hawwas, M., Manaph, N. P. A., Zhou, F., Bobrovskaya, L., . . . Zhou, X. -F. (2020). Conversion of human urine-derived cells into neuron-like cells by small molecules. Molecular Biology Reports, 47(4), 1-10.
DOI Scopus18 WoS19 Europe PMC17
2020 Li, H., Lin, L. Y., Zhang, Y., Lim, Y., Rahman, M., Beck, A., . . . Zhou, X. F. (2020). Pro-BDNF knockout causes abnormal motor behaviours and early death in mice. Neuroscience, 438, 145-157.
DOI Scopus14 WoS12 Europe PMC10
2020 Yang, C. R., Ning, L., Zhou, F. H., Sun, Q., Meng, H. P., Han, Z., . . . Zhou, X. -F. (2020). Downregulation of Adhesion Molecule CHL1 in B Cells but Not T Cells of Patients with Major Depression and in the Brain of Mice with Chronic Stress.. Neurotoxicity Research, 38(4), 914-928.
DOI Scopus17 WoS15 Europe PMC19
2020 Yu, Y. Q., Zhang, Y. L., Wang, Z., Liu, Y., Li, H., Zhou, X. F., . . . Dai, R. P. (2020). Involvement of proBDNF in monocytes/macrophages with gastrointestinal disorders in depressive mice. Neurotoxicity Research, 38(4), 1063.
DOI Scopus6 WoS7 Europe PMC5
2020 Fang, J., Wei, Z., Zheng, D., Ying, T., Hong, H., Hu, D., . . . Chen, L. (2020). Recombinant extracellular domain (p75ECD) of the neurotrophin receptor p75 attenuates myocardial ischemia-reperfusion injury by inhibiting the p-JNK/caspase-3 signaling pathway in rat microvascular pericytes. Journal of the American Heart Association, 9(13), 1-24.
DOI Scopus17 WoS17 Europe PMC18
2020 Xiong, L. L., Qin, Y. X., Xiao, Q. X., Jin, Y., Al Hawwas, M., Ma, Z., . . . Wang, T. H. (2020). MicroRNA339 targeting PDXK improves motor dysfunction and promotes neurite growth in the remote cortex subjected to spinal cord transection. Frontiers in Cell and Developmental Biology, 8(577), 1-17.
DOI Scopus7 WoS8 Europe PMC6
2020 Deng, I., Corrigan, F., Zhai, G., Zhou, X. -F., & Bobrovskaya, L. (2020). Lipopolysaccharide animal models of Parkinson's disease: Recent progress and relevance to clinical disease. Brain Behav Immun Health, 4(100060), 1-12.
DOI Scopus100 WoS86 Europe PMC68
2019 Mañucat-Tan, N. B., Shen, L. L., Bobrovskaya, L., Al-hawwas, M., Zhou, F. H., Wang, Y. J., & Zhou, X. F. (2019). Knockout of p75 neurotrophin receptor attenuates the hyperphosphorylation of Tau in pR5 mouse model. Aging, 11(17), 6762-6791.
DOI Scopus22 WoS20 Europe PMC17
2019 Chen, S., Liang, T., Zhou, F. H., Cao, Y., Wang, C., Wang, F. Y., . . . Li, C. Q. (2019). Regular music exposure in juvenile rats facilitates conditioned fear extinction and reduces anxiety after foot shock in adulthood. BioMed Research International, 2019(article no. 8740674), 1-10.
DOI Scopus14 WoS14 Europe PMC8
2019 Zhang, Z. B., Tan, Y. X., Zhao, Q., Xiong, L. L., Liu, J., Xu, F. F., . . . Wang, T. H. (2019). miRNA-7a-2-3p inhibits neuronal apoptosis in oxygen-glucose deprivation (OGD) model. Frontiers in neuroscience, 13, article 16(JAN), 1-10.
DOI Scopus33 WoS30 Europe PMC26
2019 Wang, Z., Wu, J. L., Zhong, F., Liu, Y., Yu, Y. Q., Sun, J. J., . . . Dai, R. P. (2019). Upregulation of proBDNF in the mesenteric lymph nodes in septic mice. Neurotoxicity research, 36(4), 540-550.
DOI Scopus20 WoS19 Europe PMC17
2019 Saadipour, K., Tiberi, A., Lomardo, S., Grajales, E., Montroull, L., Manucat Tan, N. B., . . . Chao, M. V. (2019). Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor. Molecular and cellular neuroscience, 99(103395), 1-15.
DOI Scopus10 WoS9 Europe PMC10
2019 Shen, L. L., Li, W. W., Xu, Y. L., Gao, S. H., Xu, M. Y., Bu, X. L., . . . Wang, Y. J. (2019). Neurotrophin receptor p75 mediates amyloid β-induced tau pathology. Neurobiology of Disease, 132(104567), 1-12.
DOI Scopus50 WoS42 Europe PMC38
2019 Luo, H. Y., Rahman, M., Bobrovskaya, L., & Zhou, X. F. (2019). The level of proBDNF in blood lymphocytes is correlated with that in the brain of rats with photothrombotic ischemic stroke. Neurotoxicity Research, 36(1), 49-57.
DOI Scopus15 WoS12 Europe PMC10
2019 Zhong, F., Liu, L., Wei, J. L., Hu, Z. L., Li, L., Wang, S., . . . Dai, R. P. (2019). Brain-derived neurotrophic factor precursor in the hippocampus regulates both depressive and anxiety-like behaviors in rats. Frontiers in psychiatry, 10(article no. 776), 1-11.
DOI Scopus37 WoS46 Europe PMC36
2019 Xu, Y., Li, W. W., Wang, J., Zhu, C., Shen, Y. Y., Shi, A. Y., . . . Wang, Y. J. (2019). Neurotrophin receptor p75 mRNA level in peripheral blood cells of patients with Alzheimer's disease. Neurotoxicity research, 36(1), 101-107.
DOI Scopus6 WoS6 Europe PMC4
2019 Yang, C. Y., Yang, J. Y., Xiong, Y. X., Zhuang, X. F., Su, H., Hu, S., . . . Sun, J. (2019). Panax notoginsenoside Rb1 restores the neurotrophic imbalance following photothrombotic stroke in rats. Neurotoxicity research, 36(3), 441-451.
DOI Scopus4 WoS3 Europe PMC3
2019 Lin, L. Y., Luo, S. Y., Al Hawwas, M., Herselman, M. F., Zhou, X. F., & Bobrovskaya, L. (2019). The long-term effects of ethanol and corticosterone on the mood-related behaviours and the balance between mature BDNF and proBDNF in mice. Journal of molecular neuroscience, 69(1), 60-68.
DOI Scopus17 WoS15 Europe PMC15
2019 Johnson, M. E., Zhou, X. F., & Bobrovskaya, L. (2019). The effects of rotenone on TH, BDNF and BDNF-related proteins in the brain and periphery: relevance to early Parkinson's disease. Journal of chemical neuroanatomy, 97, 23-32.
DOI Scopus18 WoS16 Europe PMC11
2019 Mañucat-Tan, N. B., Saadipour, K., Wang, Y. J., Bobrovskaya, L., & Zhou, X. F. (2019). Cellular trafficking of amyloid precursor protein in amyloidogenesis physiological and pathological significance. Molecular Neurobiology, 56(2), 812-830.
DOI Scopus28 WoS28 Europe PMC27
2018 Zeng, Y. Q., Cui, Y. B., Gu, J. H., Liang, C., & Zhou, X. F. (2018). Scutellarin mitigates Aβ-induced neurotoxicity and improves behavior impairments in AD mice. Molecules, 23(4, article no. 869), 1-12.
DOI Scopus30 WoS26 Europe PMC20
2018 Bu, X. L., Xiang, Y., Jin, W. S., Wang, J., Zhou, X. F., & Wang, Y. J. (2018). Blood-derived amyloid-β protein induces Alzheimer's disease pathologies. Molecular psychiatry, 23(9), 1948-1956.
DOI Scopus184 WoS158 Europe PMC166
2018 Yan, Y. T., Li, S. D., Li, C., Xiong, Y. X., Lu, X. H., Zhou, X. F., . . . Luo, H. Y. (2018). Panax notoginsenoside saponins Rb1 regulates the expressions of Akt/ mTOR/PTEN signals in the hippocampus after focal cerebral ischemia in rats. Behavioural brain research, 345, 83-92.
DOI Scopus36 WoS35 Europe PMC29
2018 Xiong, L. L., Hu, Y., Zhang, P., Zhang, Z., Li, L. H., Gao, G. D., . . . Wang, T. H. (2018). Neural stem cell transplantation promotes functional recovery from traumatic brain injury via brain derived neurotrophic factor-mediated neuroplasticity. Molecular neurobiology, 55(3), 2696-2711.
DOI Scopus57 WoS52 Europe PMC48
2018 Wang, Y. R., Wang, J., Liu, Y. H., Hu, G. L., Gao, C. Y., Wang, Y. J., . . . Zeng, F. (2018). Cysteine-rich repeat domains 2 and 4 are amyloid-β binding domains of neurotrophin receptor p75NTR and potential targets to block amyloid-β neurotoxicity. Journal of Alzheimer's disease : JAD, 63(1), 139-147.
DOI Scopus11 WoS9 Europe PMC8
2018 Liu, S., Guo, W., Zhou, H., Tang, L., Feng, S., Zhong, J. H., & Zhou, X. F. (2018). proBDNF inhibits the proliferation and migration of OLN-93 oligodendrocytes. Molecular Medicine Reports, 18(4), 3809-3817.
DOI Scopus12 WoS13 Europe PMC12
2018 Parikh, A., Kathawala, K., Song, Y., Zhou, X. F., & Garg, S. (2018). Curcumin-loaded self-nanomicellizing solid dispersion system: part I: development, optimization, characterization, and oral bioavailability. Drug Delivery and Translational Research, 8(5), 1389-1405.
DOI Scopus40 WoS31 Europe PMC22
2018 Parikh, A., Kathawala, K., Li, J., Chen, C., Shan, Z., Cao, X., . . . Garg, S. (2018). Curcumin-loaded self-nanomicellizing solid dispersion system: part II: in vivo safety and efficacy assessment against behavior deficit in Alzheimer disease. Drug delivery and translational research, 8(5), 1406-1420.
DOI Scopus40 WoS34 Europe PMC32
2018 Parikh, A., Kathawala, K., Li, J., Chen, C., Shan, Z., Cao, X., . . . Zhou, X. F. (2018). Self-nanomicellizing solid dispersion of edaravone: part II: in vivo assessment of efficacy against behavior deficits and safety in Alzheimer’s disease model. Drug Design, Development and Therapy, 12, 2111-2128.
DOI Scopus24 WoS22 Europe PMC17
2018 Parikh, A., Kathawala, K., Tan, C. C., Garg, S., & Zhou, X. F. (2018). Self-nanomicellizing solid dispersion of edaravone: part I – oral bioavailability improvement. Drug Design, Development and Therapy, 12, 2051-2069.
DOI Scopus30 WoS26 Europe PMC21
2018 Shen, L. L., Mañucat-Tan, N. B., Gao, S. H., Li, W. W., Zeng, F., Zhu, C., . . . Wang, Y. J. (2018). The proNGF/p75NTR pathway induces tau pathology and is a therapeutic target for FTLD-tau. Molecular Psychiatry, 23(8), 1813-1824.
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2018 Rahman, M., Luo, H., Sims, N. R., Bobrovskaya, L., & Zhou, X. F. (2018). Investigation of mature BDNF and proBDNF signaling in a rat photothrombotic ischemic model. Neurochemical Research, 43(3), 637-649.
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2018 Saadipour, K., Mañucat-Tan, N. B., Lim, Y., Keating, D. J., Smith, K. S., Zhong, J. H., . . . Zhou, X. F. (2018). p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis. Journal of Neurochemistry, 144(3), 302-317.
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2018 Liu, D., Manaph, N. P. A., Al-Hawwas, M., Zhou, X. F., & Liao, H. (2018). Small molecules for neural stem cell induction. Stem Cells and Development, 27(5), 297-312.
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2018 Duan, H. Q., Wu, Q. L., Yao, X., Fan, B. Y., Shi, H. Y., Zhao, C. X., . . . Feng, S. Q. (2018). Nafamostat mesilate attenuates inflammation and apoptosis and promotes locomotor recovery after spinal cord injury. CNS neuroscience and therapeutics, 24(5), 429-438.
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2018 Ruan, C. S., Liu, J., Yang, M., Saadipour, K., Zeng, Y. Q., Liao, H., . . . Zhou, X. F. (2018). Sortilin inhibits amyloid pathology by regulating non-specific degradation of APP. Experimental Neurology, 299(Pt A), 75-85.
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2018 Su, Y., Zhou, X., Foster, B., Grills, B., Xu, J., & Xian, C. (2018). Roles of neurotrophins in skeletal tissue formation and healing. Journal of Cellular Physiology, 233(3), 2133-2145.
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2018 Lim, Y., Wu, L., Chen, S., Sun, Y., Vijayaraj, S., Yang, M., . . . Zhou, X. (2018). HAP1 is required for endocytosis and signalling of BDNF and its receptors in neurons. Molecular Neurobiology, 55(3), 1815-1830.
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2018 Zhou, L., Xiong, J., Ruan, C. S., Ruan, Y., Liu, D., Bao, J. J., & Zhou, X. F. (2018). ProBDNF/p75NTR/sortilin pathway is activated in peripheral blood of patients with alcohol dependence. Translational Psychiatry, 7(11), 2-1-2-10.
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2018 Huang, H., Young, W., Chen, L., Feng, S., Zhou, X. F., & Li, T. (2018). Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017). Cell transplantation, 27(2), 310-324.
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2018 Yi, X., Liu, Y. H., Zhou, X. F., Wang, Y. J., Deng, J., Liu, J., . . . Xu, Z. Q. (2018). The influence of abdominal and ectopic fat accumulation on carotid intima-media thickness: a Chongqing study. Journal of stroke and cerebrovascular diseases, 27(7), 1992-1997.
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2018 Pavathuparambil Abdul Manaph, N., Al-Hawaas, M., Bobrovskaya, L., Coates, P. T., & Zhou, X. F. (2018). Urine-derived cells for human cell therapy. Stem Cell Research and Therapy, 9(1), 189-1-189-12.
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2018 Su, Y. W., Chim, S. M., Zhou, L., Hassanshahi, M., Chung, R., Fan, C., . . . Xian, C. J. (2018). Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats. Bone, 116, 232-247.
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2018 Pavathuparambil Abdul Manaph, N., Al Hawwas, M., Liu, L., Liu, D., Hayball, J., & Zhou, X. F. (2018). Facial vein injection of human cells in severe combined immunodeficiency (SCID) neonatal mice. MethodsX, 5, 1281-1286.
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2018 Pavathuparambil Abdul Manaph, N., Al Hawwas, M., & Zhou, X. F. (2018). A direct and non-invasive method for kidney delivery of therapeutics in mice. MethodsX, 5, 1440-1446.
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2018 Xiong, L. L., Xiao, Q. X., AI Hawwas, M., Bobrovskaya, L., Liu, D. H., & Zhou, X. F. (2018). Treatment of hypoxic-ischemic encephalopathy in neonates: a systematic review and meta-analysis. Ibrain, 4(4), 52-61.
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2018 Ruan, C. S., Zeng, Y. Q., Guo, Y., Bobrovskaya, L., & Zhou, X. F. (2018). A pilot study in modeling mood disorders in mice by chronic tail-suspension stress. Neuropsychiatry, 8(5), 1586-1592.
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2017 Ruan, C. S., Bobrovskaya, L., & Zhou, X. F. (2017). Female wild-type and APP/PS1 transgenic mice deficient in Sort1 are prone to anxiety-like behavior at older ages. Neuropsychiatry, 7(6), 1047-1052.
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2017 Li, J. Y., Liu, J., Manaph, N. P. A., Bobrovskaya, L., & Zhou, X. F. (2017). ProBDNF inhibits proliferation, migration and differentiation of mouse neural stem cells. Brain Research, 1668, 46-55.
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2017 Chen, J., Zhang, T., Jiao, S., Zhou, X., Zhong, J., Wang, Y., . . . Xu, Z. (2017). ProBDNF Accelerates Brain Amyloid-β Deposition and Learning and Memory Impairment in APPswePS1dE9 Transgenic Mice. Journal of Alzheimer's Disease, 59(3), 941-949.
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2017 Jin, W. S., Shen, L. L., Bu, X. L., Zhang, W. W., Chen, S. H., Huang, Z. L., . . . Wang, Y. J. (2017). Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model. Acta neuropathologica, 134(2), 207-220.
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2017 Yang, C. R., Bai, Y. Y., Ruan, C. S., Zhou, F. H., Li, F., Li, C. Q., & Zhou, X. F. (2017). Injection of anti-proBDNF in anterior cingulate cortex (ACC) reverses chronic stress-induced adverse mood behaviors in mice. Neurotoxicity Research, 31(2), 298-308.
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2017 Liu, Y., Li, C., Wang, J., Fang, Y., Sun, H., Tao, X., . . . Liao, H. (2017). Nafamostat mesilate improves neurological outcome and axonal regeneration after stroke in rats. Molecular neurobiology, 54(6), 4217-4231.
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2017 Lim, Y. Y., Rainey-Smith, S., Lim, Y., Laws, S. M., Gupta, V., Porter, T., . . . Maruff, P. (2017). BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International Psychogeriatrics, 29(11), 1825-1834.
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2017 Hu, X., Hu, Z. L., Li, Z., Ruan, C. S., Qiu, W. Y., Pan, A., . . . Yan, X. X. (2017). Sortilin fragments deposit at senile plaques in human cerebrum. Frontiers in Neuroanatomy, 11(45), 45-1-45-19.
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2017 Liang, C., Yuan, J. P., DIng, T., Yan, L., Ling, L., Zhou, X. F., & Zeng, Y. Q. (2017). Neuroprotective effect of Fagopyrum dibotrys extract against Alzheimer's disease. Evidence-based complementary and alternative medicine, 2017(1), 1-9.
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2017 Wang, S., Li, M., Guo, Y., Li, C., Wu, L., Zhou, X. F., . . . Pu, L. (2017). Effects of Panax notoginseng ginsenoside Rb1 on abnormal hippocampal microenvironment in rats. Journal of Ethnopharmacology, 202, 138-146.
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2017 Mackenzie, K. D., Lim, Y., Duffield, M. D., Chataway, T., Zhou, X. F., & Keating, D. J. (2017). Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins. Cellular Signalling, 35, 176-187.
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2017 Yang, J. W., Ma, W., Yang, Y. L., Wang, X. B., Li, X. T., Wang, T. T., . . . Li, L. Y. (2017). Region-specific expression of precursor and mature brain-derived neurotrophic factors after chronic alcohol exposure. American journal of drug and alcohol abuse, 43(5), 602-608.
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2017 Parikh, A., Kathawala, K., Tan, C. C., Garg, S., & Zhou, X. F. (2017). Lipid-based nanosystem of edaravone: development, optimization, characterization and in vitro/in vivo evaluation. Drug delivery, 24(1), 962-978.
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2016 Lou, C., Xu, J. M., Zhou, X. F., & Hurtado, P. R. (2016). TLR9-mediated B cells activation leads to production of brain-derived neurotrophic factor: possible neuroprotective role of B cells following infection. European journal of immunology, 46(S1, article no. 1161), 1142.
2016 Fang, Y., Yao, L., Li, C., Wang, J., Wang, J., Chen, S., . . . Liao, H. (2016). The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice. Journal of neuroinflammation, 13(56), 1-17.
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2016 Senthilkumaran, M., Zhou, X. F., & Bobrovskaya, L. (2016). Challenges in Modelling Hypoglycaemia-Associated Autonomic Failure: A Review of Human and Animal Studies. International Journal of Endocrinology, 2016(article no. 9801640), 13 pages.
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2016 Parikh, A., Kathawala, K., Tan, C. C., Garg, S., & Zhou, X. F. (2016). Development of a novel oral delivery system of edaravone for enhancing bioavailability. International Journal of Pharmaceutics, 515(1-2), 490-500.
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2016 Ding, Y. Q., Li, X. Y., Xia, G. N., Ren, H. Y., Zhou, X. F., Su, B. Y., & Qi, J. G. (2016). ProBDNF inhibits collective migration and chemotaxis of rat Schwann cells. Tissue and Cell, 48(5), 503-510.
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2016 Jiao, S. S., Shen, L. L., Zhu, C., Bu, X. L., Liu, Y. H., Liu, C. H., . . . Wang, Y. J. (2016). Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease. Translational Psychiatry, 6(10), 11 pages.
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2016 Mackenzie, K. D., Lumsden, A. L., Guo, F., Duffield, M. D., Chataway, T., Lim, Y., . . . Keating, D. J. (2016). Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Journal of Neurochemistry, 138(5), 710-721.
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2016 Wang, Q. H., Wang, Y. R., Zhang, T., Jiao, S. S., Liu, Y. H., Zeng, F., . . . Wang, Y. J. (2016). Intramuscular delivery of p75NTR ectodomain by an AAV vector attenuates cognitive deficits and Alzheimer's disease-like pathologies in APP/PS1 transgenic mice. Journal of Neurochemistry, 138(1), 163-173.
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2016 Ruan, C. S., Yang, C. R., Li, J. Y., Luo, H. Y., Bobrovskaya, L., & Zhou, X. F. (2016). Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior. Experimental Neurology, 281, 99-108.
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2016 Li, F., Cao, W. Y., Huang, F. L., Kang, W. J., Zhong, X. L., Hu, Z. L., . . . Li, C. Q. (2016). Roles of NMDA and dopamine in food-foraging decision-making strategies of rats in the social setting. BMC Neuroscience, 17(1), 9 pages.
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2016 Luo, C., Zhong, X. -L., Zhou, F. H., Li, J. -Y., Zhou, P., Xu, J. -M., . . . Dai, R. -P. (2016). Peripheral Brain Derived Neurotrophic Factor Precursor Regulates Pain as an Inflammatory Mediator. Scientific Reports, 6(2, article no. 27171), 27171-1-27171-11.
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2016 Shan, Z. N., Tian, R., Zhang, M., Gui, Z. H., Wu, J., Ding, M., . . . He, J. (2016). miR128-1 inhibits the growth of glioblastoma multiforme and glioma stem-like cells via targeting BMI1 and E2F3. Oncotarget, 7(48), 78813-78826.
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2016 Zhou, L., Liu, D., Zeng, Y. Q., Wang, T. H., Tian, C. F., Liao, H., . . . Zhou, X. F. (2016). ProBDNF signaling regulates depression-like behaviors in rodents under chronic stress. Neuropsychopharmacology, 41(12), 2882-2892.
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2016 Su, Y. W., Chung, R., Ruan, C. S., Chim, S. M., Kuek, V., Dwivedi, P. P., . . . Xian, C. J. (2016). Neurotrophin-3 induces BMP-2 and VEGF activities and promotes the bony repair of injured growth plate cartilage and bone in rats. Journal of Bone and Mineral Research, 31(6), 1258-1274.
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2016 Li, C., Wang, J., Fang, Y., Liu, Y., Chen, T., Sun, H., . . . Liao, H. (2016). Nafamostat mesilate improves function recovery after stroke by inhibiting neuroinflammation in rats. Brain, behavior, and immunity, 56, 230-245.
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2016 Han, Y. C., Lim, Y., Duffieldl, M. D., Li, H., Liu, J., Abdul Manaph, N. P., . . . Zhou, X. F. (2016). Direct reprogramming of mouse fibroblasts to neural stem cells by small molecules. Stem Cells International, 2016(4304916), 4304916-1-4304916-11.
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2016 Ruan, C. S., Bobrovskaya, L., & Zhou, X. F. (2016). Absence of sortilin increases the convergence of app and bace1 in soma. Alzheimer's and dementia, 12(7), 455.
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2015 Xiong, J., Zhou, L., Lim, Y., Yang, M., Zhu, Y., Wei Li, Z., . . . Zhou, X. (2015). Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues. Oncology Letters, 10(1), 223-227.
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2015 Ruan, C., Zhou, F., He, Z., Wang, S., Yang, C., Shen, Y., . . . Zhou, X. (2015). Mice deficient for wild-type p53-induced phosphatase 1 display elevated anxiety- and depression-like behaviors. Neuroscience, 293, 12-22.
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2015 Zhou, F., Yu, Y., Zhou, X., & Xian, C. (2015). Methotrexate chemotherapy triggers touch-evoked pain and increased CGRP-positive sensory fibres in the tibial periosteum of young rats. Bone, 73, 24-31.
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2015 Yao, X. Q., Jiao, S. S., Saadipour, K., Zeng, F., Wang, Q. H., Zhu, C., . . . Wang, Y. J. (2015). p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease. Molecular Psychiatry, 20(11), 1301-1310.
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2015 Jiao, S. S., Yao, X. Q., Liu, Y. H., Wang, Q. H., Zeng, F., Lu, J. J., . . . Wang, Y. J. (2015). Edaravone alleviates Alzheimer's disease-type pathologies and cognitive deficits. Proceedings of the National Academy of Sciences of the United States of America, 112(16), 5225-5230.
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2015 Liu, Y. H., Wang, Y. R., Xiang, Y., Zhou, H. D., Giunta, B., Mañucat-Tan, N. B., . . . Wang, Y. J. (2015). Clearance of Amyloid-Beta in Alzheimer’s Disease: Shifting the Action Site from Center to Periphery. Molecular Neurobiology, 51(1), 1-7.
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2015 Xiang, Y., Bu, X. L., Liu, Y. H., Zhu, C., Shen, L. L., Jiao, S. S., . . . Wang, Y. J. (2015). Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer's disease. Acta Neuropathologica, 130(4), 487-499.
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2015 Lim, Y., Zhong, J. H., & Zhou, X. F. (2015). Development of mature BDNF-specific sandwich ELISA. Journal of Neurochemistry, 134(1), 75-85.
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2015 Johnson, M. E., Lim, Y., Senthilkumaran, M., Zhou, X. F., & Bobrovskaya, L. (2015). Investigation of tyrosine hydroxylase and BDNF in a low-dose rotenone model of Parkinson's disease. Journal of Chemical Neuroanatomy, 70, 33-41.
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2015 Zhou, X. F., Bai, Y. Y., Ruan, C., Zhou, L., & Yang, C. (2015). Role of probdnf in the rodent model of depression. Journal of neurochemistry, 134, 320.
2015 Wang, X., Ba, Y., Xiong, L. L., Li, X. L., Zou, Y., Zhu, Y., . . . Li, J. (2015). Endogenous TGFB1 Plays a Crucial Role in Functional Recovery After Traumatic Brain Injury Associated with Smad3 Signal in Rats. Neurochemical Research, 40(8), 1671-1680.
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2015 Rong, R., Wang, Y. C., Hu, L. Q., He, Q. Q., Zhou, X. F., Wang, T. H., & Bu, P. L. (2015). Role of endogenous PDGF-BB in cultured cardiomyocytes exposed to hypoxia. Neuropeptides, 50, 43-49.
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2015 Wang, X. Q., Zhong, X. L., Li, Z. B., Wang, H. T., Zhang, J., Li, F., . . . Bi, F. F. (2015). Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats. BMC neuroscience, 16(1), 1-12.
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2014 Wang, Y. C., Xia, Q. J., Ba, Y. C., Wang, T. Y., Lin, N., Zou, Y., . . . Qi, J. G. (2014). Transplantation of olfactory ensheathing cells promotes the recovery of neurological functions in rats with traumatic brain injury associated with downregulation of Bad. Cytotherapy, 16(7), 1000-1010.
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2014 Liu, Y. H., Jiao, S. S., Wang, Y. R., Bu, X. L., Yao, X. Q., Xiang, Y., . . . Wang, Y. J. (2014). Associations between ApoEɛ4 carrier status and serum BDNF levels, new insights into the molecular mechanism of ApoEɛ4 actions in Alzheimer's disease. Molecular neurobiology, 51(3), 1271-1277.
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2014 Yang, X., Liu, J., Liu, Z. J., Xia, Q. J., He, M., Liu, R., . . . Wang, T. H. (2014). Reversal of bone cancer pain by HSV-1-mediated silencing of CNTF in an afferent area of the spinal cord associated with AKT-ERK signal inhibition. Current gene therapy : the international journal for in-depth reviews on gene therapy, 14(5), 377-388.
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2014 Xiang, J., Yang, H., Zhao, T., Sun, M., Xu, X., Zhou, X. F., . . . Li, X. J. (2014). Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting. Journal of clinical investigation, 124(1), 85-98.
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2014 Zeng, Y. Q., Wang, Y. J., & Zhou, X. F. (2014). Effects of (-)epicatechin on the pathology of APP/PS1 transgenic mice. Frontiers in Neurology, 5(69), 69-1-69-10.
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2014 Li, C. -Q., Luo, Y. -W., Bi, F. -F., Cui, T. -T., Song, L., Cao, W. -Y., . . . Dai, R. -P. (2014). Development of anxiety-like behavior via hippocampal IGF-2 signaling in the offspring of parental morphine exposure: effect of enriched environment. Neuropsychopharmacology, 39(12), 2777-2787.
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2014 Wang, W., Wang, F., Liu, J., Zhao, W., Zhao, Q., He, M., . . . Wang, T. Y. (2014). SNAP25 Ameliorates Sensory Deficit in Rats with Spinal Cord Transection. Molecular Neurobiology, 50(2), 290-304.
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2014 Ruan, C., Wang, S., Shen, Y., Guo, Y., Yang, C., Zhou, F., . . . Zhou, X. (2014). Deletion of TRIM32 protects mice from anxiety- and depression-like behaviors under mild stress. The European journal of neuroscience, 40(4), 2680-2690.
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2014 Yang, C., Zhang, Z., Bai, Y., Zhou, H., Zhou, L., Ruan, C., . . . Zhou, X. (2014). Foraging activity is reduced in a mouse model of depression. Neurotoxicity Research, 25(3), 235-247.
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2014 Mackenzie, K., Duffield, M., Peiris, H., Phillips, L., Zanin, M., Teo, E., . . . Keating, D. (2014). Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cells. The Journal of Physiology, 592(7), 1505-1518.
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2014 Yang, C. R., Bai, Y. Y., Ruan, C. S., Zhou, H. F., Liu, D., Wang, X. F., . . . Zhou, X. F. (2014). Enhanced aggressive behaviour in a mouse model of depression. Neurotoxicity Research, 27(2), 129-142.
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2013 Zheng, F., Zou, H. Q., Zhou, H. D., Li, J., Wang, L., Cao, H. Y., . . . Wang, Y. J. (2013). The relationship between single nucleotide polymorphisms of the NTRK2 gene and sporadic Alzheimer's disease in the Chinese Han population. Neuroscience letters, 550, 55-59.
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2013 Zeng, F., Deng, Y. P., Yi, X., Cao, H. Y., Zou, H. Q., Wang, X., . . . Wang, Y. J. (2013). No association of SORT1 gene polymorphism with sporadic Alzheimer's disease in the Chinese Han population. Neuroreport, 24(9), 464-468.
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2013 Zhou, L., Xiong, J., Lim, Y., Ruan, Y., Huang, C., Zhu, Y., . . . Zhou, X. F. (2013). Upregulation of blood proBDNF and its receptors in major depression. Journal of Affective Disorders, 150(3), 776-784.
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2013 Shang, F. F., Zhao, W., Zhao, Q., Liu, J., Li, D. W., Zhang, H., . . . Wang, T. H. (2013). Upregulation of eIF-5A1 in the paralyzed muscle after spinal cord transection associates with spontaneous hindlimb locomotor recovery in rats by upregulation of the ErbB, MAPK and neurotrophin signal pathways. Journal of proteomics, 91, 188-199.
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2013 Xiong, J., Zhou, L., Lim, Y., Yang, M., Zhu, Y., Li, Z., . . . Zhou, X. (2013). Mature BDNF promotes the growth of glioma cells in vitro. Oncology Reports, 30(6), 2719-2724.
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2013 Saadipour, K., Yang, M., Lim, Y., Georgiou, K., Sun, Y., Keating, D., . . . Zhou, X. (2013). Amyloid beta₁–-₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75NTR/RhoA signaling pathway. Journal of Neurochemistry, 127(2), 152-162.
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2013 Xiong, J., Zhou, L., Yang, M., Lim, Y., Zhu, Y., Fu, D., . . . Zhou, X. (2013). ProBDNF and its receptors are upregulated in glioma and inhibit the growth of glioma cells in vitro. Neuro-Oncology, 15(8), 990-1007.
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2013 Yang, M., Virassamy, B., Vijayaraj, S., Lim, Y., Saadipour, K., Wang, Y., . . . Zhou, X. (2013). The intracellular domain of sortilin interacts with Amyloid precursor protein and regulates its lysosomal and lipid raft trafficking. PLoS One, 8(5), e63049-1-e63049-13.
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2013 Guo, J., Wang, J., Liang, C. R., Yan, J., Wang, Y., Liu, G., . . . Liao, H. (2013). proNGF inhibits proliferation and oligodendrogenesis of postnatal hippocampal neural stem/progenitor cells through p75NTR in vitro. Stem cell research, 11(2), 874-887.
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2013 Li, Y. H., Jiang, Y., Xiong, J., Zhou, X. F., Wang, Y., & Li, G. C. (2013). A monoclonal antibody against the extracellular domain of P75 neurotrophin receptor. Monoclonal antibodies in immunodiagnosis and immunotherapy, 32(1), 55-59.
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2013 Majd, S., Chegini, F., Chataway, T., Zhou, X. F., & Gai, W. (2013). Reciprocal induction between α-synuclein and β-amyloid in adult rat neurons. Neurotoxicity Research, 23(1), 69-78.
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2013 Luo, Y., Zou, Y., Yang, L., Liu, J., Liu, S., Liu, J., . . . Wang, T. (2013). Transplantation of NSCs with OECs alleviates neuropathic pain associated with NGF downregulation in rats following spinal cord injury. Neuroscience letters, 549, 103-108.
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2013 Su, Y. W., Chung, R., Vincent, C., Chim, S. M., Zhou, F., Lee, A., . . . Xian, C. (2013). Potential roles of neurotrophin-3 in growth plate cartilage bony repair and skeletal cell formation. Journal of bone and mineral research, 28(1), 107.
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2012 Li, H., Li, C., Dai, R., Shi, X., Xu, J., Zhang, J., . . . Luo, X. (2012). Expression of acetylated histone 3 in the spinal cord and the effect of morphine on inflammatory pain in rats. Neural regeneration research, 7(7), 517-522.
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2012 Li, F., Li, M., Cao, W., Xu, Y., Luo, Y., Zhong, X., . . . Li, C. (2012). Anterior cingulate cortical lesion attenuates food foraging in rats. Brain research bulletin, 88(6), 602-608.
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2012 Yan, J., Zhou, X., Guo, J. J., Mao, L., Wang, Y. J., Sun, J., . . . Liao, H. (2012). Nogo-66 inhibits adhesion and migration of microglia via GTPase Rho pathway in vitro. Journal of Neurochemistry, 120(5), 721-731.
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2012 Li, F., Cao, W. Y., Li, M. B., Xu, Y., Zhang, J. W., Zhang, J. Y., . . . Li, C. Q. (2012). A simple method for detection of food foraging behavior in the rat : involvement of NMDA and dopamine receptors in the behavior. Neuroscience, 205(15), 73-80.
DOI Scopus20 WoS18 Europe PMC14
2012 Yang, G., Yang, M., Lim, Y., Lu, J., Wang, T., Qi, J., . . . Zhou, X. (2012). Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons. Journal of Neurochemistry, 122(5), 1010-1022.
DOI Scopus33 WoS33 Europe PMC29
2012 Sun, Y., Lim, Y., Li, F., Liu, S., Lu, J. J., Haberberger, R., . . . Zhou, X. F. (2012). ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA. PLoS ONE, 7(4), 1-12.
DOI Scopus133 WoS95 Europe PMC111
2012 Zhang, F., Kang, Z., Li, W., Xiao, Z., & Zhou, X. (2012). Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer's disease. Journal of clinical neuroscience, 19(7), 946-949.
DOI Scopus91 WoS82 Europe PMC63
2012 Yu, H., Yang, M., Wang, Y., Xiao, R., & Zhou, X. -F. (2012). p75NTR is mainly responsible for A beta toxicity but not for its internalization: a primary study. Neurological Sciences, 33(5), 1043-1050.
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2011 Wang, Y., Wang, X., Lu, J., Li, Q., Gao, C., Liu, X., . . . Zhou, X. (2011). p75NTR regulates Aβ deposition by increasing Aβ production but inhibiting Aβ aggregation with its extracellular domain. Journal of Neuroscience, 31(6), 2292-2304.
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2011 Tam Tam, S., Bastian, I., Zhou, X., Vander Hoek, M., Michael, M., Gibbins, I., & Haberberger, R. (2011). MicroRNA-143 expression in dorsal root ganglion neurons. Cell and Tissue Research, 346(2), 163-173.
DOI Scopus40 WoS36 Europe PMC34
2011 Bastian, I., Tam Tam, S., Zhou, X., Kazenwadel, J., Van Der Hoek, M., Michael, M., . . . Haberberger, R. (2011). Differential expression of microRNA-1 in dorsal root ganglion neurons. Histochemistry and Cell Biology, 135(1), 37-45.
DOI Scopus17 WoS16 Europe PMC17
2011 Aguilar, S. E. A., Pollard, A. N., Smith, M., & Zhou, X. F. (2011). Macrophage presence is essential for the regeneration of ascending afferent fibres following a conditioning sciatic nerve lesion in adult rats. BMC Neuroscience, 11(11), 1-13.
DOI Scopus22 WoS21 Europe PMC20
2011 Xu, Z. Q., Sun, Y., Li, H. Y., Lim, Y., Zhong, J. H., & Zhou, X. F. (2011). Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice. European journal of neuroscience, 33(8), 1376-1384.
DOI Scopus57 WoS53 Europe PMC48
2011 Yang, M., Lim, Y., Li, X., Zhong, J., & Zhou, X. (2011). Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing. Journal of Biological Chemistry, 286(18), 16272-16284.
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2011 Li, F., Wang, X. S., Dai, R. P., Zhang, J. Y., Zhou, X. F., Hao, W., & Li, C. Q. (2011). The activation of NMDA receptor-ERK pathway in the central amygdala is required for the expression of morphine-conditioned place preference in the rat. Neurotoxicity research, 20(4), 362-371.
DOI Scopus29 WoS29 Europe PMC26
2011 Zeng, F., Lu, J. J., Zhou, X. F., & Wang, Y. J. (2011). Roles of p75NTR in the pathogenesis of Alzheimer's disease: a novel therapeutic target. Biochemical pharmacology, 82(10), 1500-1509.
DOI Scopus64 WoS60 Europe PMC54
2011 Zhou, X. F., & Wang, Y. J. (2011). The p75NTR extracellular domain: a potential molecule regulating the solubility and removal of amyloid-β. Prion, 5(3), 161-163.
DOI Scopus21 WoS20 Europe PMC18
2011 Dai, R., Li, C. Q., Zhang, J. W., Li, F., Shi, X., Zhang, J., & Zhou, X. F. (2011). Biphasic activation of extracellular signal-regulated kinase in anterior cingulate cortex distinctly regulates the development of pain-related anxiety and mechanical hypersensitivity in rats after incision. Anesthesiology, 115(3), 604-613.
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2011 Jia, L., Yu, Z., Hui, L., Yu Guang, G., Zhou, X. F., Chao, Y., . . . Ting Hua, W. (2011). Fas and FasL expression in the spinal cord following cord hemisection in the monkey. Neurochemical research, 36(3), 419-425.
DOI Scopus14 WoS13 Europe PMC11
2011 Lockshin, L. S., Cohen, E., & Zhou, X. F. (2011). What Influences five-star Beijing restaurants in making wine lists?. Journal of wine research, 22(3), 227-243.
DOI Scopus15
2010 Li, F., Zhang, J. W., Wei, R., Luo, X. G., Zhang, J. Y., Zhou, X. F., . . . Dai, R. (2010). Sex-differential modulation of visceral pain by brain derived neurotrophic factor (BDNF) in rats. Neuroscience Letters, 478(3), 184-187.
DOI Scopus15 WoS13 Europe PMC11
2010 Li, C. Q., Zhang, J. W., Dai, R. P., Wang, J., Luo, X. G., & Zhou, X. F. (2010). Surgical incision induces anxiety-like behavior and amygdala sensitization: Effects of morphine and gabapentin. Pain research and treatment, 2010(705874), 1-9.
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2010 Wang, Y., Zhou, H., & Zhou, X. F. (2010). Modified immunotherapies against Alzheimer's disease: toward safer and effective amyloid-ß clearance. Journal of Alzheimer's Disease, 21(4), 1065-1075.
DOI Scopus23 WoS22 Europe PMC18
2010 Wong, I., Liao, H., Bai, X., Zaknic, A., Zhong, J., Guan, Y., . . . Zhou, X. F. (2010). ProBDNF inhibits infiltration of ED1+ macrophages after spinal cord injury. Brain, behavior, and immunity, 24(4), 585-597.
DOI Scopus58 WoS56 Europe PMC53
2010 Aguilar, S. E. A., Pollard, A., Smith, M., & Zhou, X. F. (2010). Sciatic nerve conditioning lesion increases macrophage response but it does not promote the regeneration of injured optic nerves. Brain research, 12, 1361.
DOI Scopus3 WoS3 Europe PMC3
2010 Wu, L. L. Y., Fan, Y., Li, S., Li, X. J., & Zhou, X. F. (2010). Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. Journal of Biological Chemistry, 285(8), 5614-5623.
DOI Scopus70 WoS63 Europe PMC61
2010 Wang, Y. J., Gao, C. Y., Yang, M., Liu, X. H., Sun, Y., Pollard, A., . . . Zhou, X. F. (2010). Intramuscular delivery of a single chain antibody gene prevents brain Aβ deposition and cognitive impairment in a mouse model of Alzheimer's disease. Brain, Behavior, and Immunity, 24(8), 1281-1293.
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2010 WANG, Y., Valadares, D., Sun, Y., Wang, X., Zhong, J., Liu, X. H., . . . Zhou, X. F. (2010). Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism. Neurotoxicity research, 17(3), 257-267.
DOI Scopus35 WoS34 Europe PMC27
2009 Wang, Y., Thomas, P., Zhong, J., Bi, F., Kosaraju, S., Pollard, A., . . . Zhou, X. (2009). Consumption of grape seed extract prevents amyloid-β deposition and attenuates inflammation in brain of an Alzheimer’s disease mouse. Neurotoxicity Research, 15(1), 3-14.
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2009 Thomas, P., Wang, Y., Zhong, J., Kosaraju, S., Callaghan, N., Zhou, X., & Fenech, M. (2009). Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 661(1-2), 25-34.
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2009 Wu, L. L. Y., & Zhou, X. F. (2009). Huntingtin associated protein 1 and its functions. Cell adhesion and migration, 71(1), 3-76.
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2009 Song, X. Y., Zhang, F. H., Zhou, F. H., Zhong, J., & Zhou, X. F. (2009). Deletion of p75NTR impairs regeneration of peripheral nerves in mice. Life sciences, 84(3-4), 61-68.
DOI Scopus15 WoS14 Europe PMC12
2009 Li, F., Li, L., Song, X. Y., Zhong, J. H., Luo, X. G., Xian, C. J., & Zhou, X. F. (2009). Preconditioning selective ventral root injury promotes plasticity of ascending sensory neurons in the injured spinal cord of adult rats - possible roles of brain-derived neurotrophic factor, TrkB and p75 neurotrophin receptor. European journal of neuroscience, 30(7), 1280-1296.
DOI Scopus20 WoS18 Europe PMC14
2009 Wang, Y. J., Pollard, A., Zhong, J. H., Dong, X. Y., Wu, X. B., Zhou, H. D., & Zhou, X. F. (2009). Intramuscular delivery of a single chain antibody gene reduces brain Aβ burden in a mouse model of Alzheimer's disease. Neurobiology of aging, 30(3), 364-376.
DOI Scopus55 WoS47 Europe PMC40
2008 Fan, Y., Linyan Wu, L., Li, H., Wang, Y., & Zhou, X. (2008). Differential effects of pro-BDNF on sensory neurons after sciatic nerve transection in neonatal rats. European Journal of Neuroscience, 27(9), 2380-2390.
DOI Scopus58 WoS55 Europe PMC53
2008 Feng, S. Q., Zhou, X. F., Rush, R. A., & Ferguson, I. A. (2008). Graft of pre-injured sural nerve promotes regeneration of corticospinal tract and functional recovery in rats with chronic spinal cord injury. Brain research, 1209, 40-48.
DOI Scopus22 WoS17 Europe PMC15
2008 Li, H. Y., & Zhou, X. F. (2008). Potential conversion of adult clavicle-derived chondrocytes into neural lineage cells in vitro. Journal of Cellular Physiology, 630(3), 214-644.
DOI Scopus9 WoS8 Europe PMC6
2008 Song, X. Y., Li, F., Zhang, F., Zhong, J. H., & Zhou, X. F. (2008). Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spina cord injury. PLoS one, 3(3), 1-16.
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2008 Bi, F. F., Xiao, Y. H., Hu, H., Tian, F. F., Wu, Y., Ding, L., & Zhou, X. F. (2008). Expression and localization of Fas-associated proteins following focal cerebral ischemia in rats. Brain research, 1191, 30-38.
DOI Scopus17 WoS14 Europe PMC9

Year Citation
2017 Zhou, X., Parikh, A., & Garg, S. (2017). WO2017157350, Edaravone dosage form.
  • Characterization of beta cell-like cells coverted from human urine stem cells, Channel 7 Children's Research Foundation of SA, 01/01/2018 - 31/12/2018

  • Research and development on the application of stem cells for regenerative medicine, Bonus Capital Limited, 18/08/2015 - 15/12/2018

  • The roles of neurotrophins and their receptors in the development of Alzheimer's disease and spinal cord injury, NHMRC - Research Fellowship, 01/03/2012 - 31/12/2017

Date Role Research Topic Program Degree Type Student Load Student Name
2021 Co-Supervisor Discovering the Roles of Orexins in Parkinson's disease Doctor of Philosophy Doctorate Full Time Ms Alisha Braun

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