Mr Weranga Rajapaksha Gedara

Higher Degree by Research Candidate

School of Pharmacy and Biomedical Sciences

College of Health


PhD Researcher | Nanomedicine & Targeted Drug Delivery | Lipid Nanoparticles (LNPs) | Cancer Therapeutics
 
I am a final-year PhD researcher at the University of Adelaide, specialising in nanomedicine and targeted drug delivery systems, with a strong focus on improving precision cancer therapeutics. My research integrates materials science, pharmaceutical engineering, and molecular targeting strategies to develop advanced nanoparticle-based treatments for oncology.
 
My doctoral research, “Co‑targeting of ovarian and prostate cancer cells using nanomedicine,” investigates the development of ligand-functionalised lipid nanoparticles (LNPs) for selective and efficient drug delivery. My work focuses on engineering LNP systems loaded with synergistic drug combinations, designed to enhance therapeutic efficacy while minimising off-target toxicity.
 
A key aspect of my research is the use of surface-modified nanoparticles decorated with targeting ligands that bind to overexpressed G protein-coupled receptors (GPCRs) on cancer cells. By exploiting these molecular signatures, I aim to achieve precise and selective targeting of ovarian and prostate cancer cells, enabling improved cellular uptake, enhanced drug accumulation at tumour sites, and more effective treatment outcomes.
Through a combination of formulation optimisation and systematic experimental design approaches, I investigate how nanoparticle composition, surface chemistry, and drug ratios influence delivery efficiency, stability, and biological performance. 

Language Competency
English Can read, write, speak, understand spoken and peer review
Sinhala; Sinhalese Can read, write, speak, understand spoken and peer review

Date Institution name Country Title
2017 - 2021 Sri Lanka Institute of Nanotechnology Sri Lanka Master of Philosophy in Nano and Advanced Technology
2013 - 2017 General Sir John Kotelawala Defence University Sri Lanka Bachelor of Pharmacy Hons

Year Citation
2026 Khetan, R., Donnellan, L., Collins, K., Kamath, S., Ariaee, A., Rajapaksha, W., . . . Joyce, P. (2026). The gut microbiota regulates the protein corona formation, biodistribution, and cellular uptake of lipid nanoparticles. Journal of Controlled Release, 395, 15 pages.
DOI
2026 Khetan, R., Rajapaksha, W., Nturubika, B. D., Gillam, T. A., Brooks, D. A., Garg, S., . . . Eldi, P. (2026). Targeting F2R/PAR1 with ligand decorated lipid nanocarriers for enhanced drug delivery into ovarian cancer cells. Frontiers in Drug Delivery, 5, 15 pages.
DOI
2024 Rajapaksha, W., Khetan, R., Johnson, I. R. D., Blencowe, A., Garg, S., Albrecht, H., & Gillam, T. A. (2024). Future theranostic strategies: emerging ovarian cancer biomarkers to bridge the gap between diagnosis and treatment. Frontiers in Drug Delivery, 4(1339936), 19 pages.
DOI Scopus19 WoS11 Europe PMC6
2024 Oehler, J. B., Rajapaksha, W., & Albrecht, H. (2024). Emerging Applications of Nanoparticles in the Diagnosis and Treatment of Breast Cancer. Journal of Personalized Medicine, 14(7), 18 pages.
DOI Scopus56 WoS36 Europe PMC16
2024 Rajapaksha, W., Nicholas, I. H. W., Thoradeniya, T., Karunaratne, D. N., & Karunaratne, V. (2024). Novel alginate nanoparticles for the simultaneous delivery of iron and folate: a potential nano-drug delivery system for anaemic patients. Rsc Pharmaceutics, 1(2), 259-271.
DOI Scopus27 WoS26
2022 Welideniya, D. T., Jayathilaka, A. S., Acharige, A. D., Samanthi, K. A. U., Wanninayake, U. K., Perera, S. S., . . . Gunasekera, D. S. (2022). Practical and scalable synthesis of beclomethasone dipropionate. STEROIDS, 177, 6 pages.
DOI WoS1 Europe PMC1
2020 Rajapaksha1, R. G. W. D. B., Silva, A. R. N., Ratnasooriya, W. D., Fernando, B. A. R., Thennakoon, T. M. A. B., & Singhabahu, S. (2020). Evaluation of in vitro antibacterial activity of extract of semi- aquatic plants growing in the polluted water of Sri Lanka. International Journal of Pharmacognosy and Life Science, 1(1), 42-50.
DOI
- Senadeera, S. P. N. N., Fernando, K. S. K., Wickramasekara, W. L. L. N., Fernando, M. Y. S., Ranaweera, C. B., Rajapaksha, W., & Silva, A. R. N. (2021). Antibacterial Activity of Endemic Artocarpus nobilis Thw Found in Sri Lanka. South Asian Journal of Research in Microbiology, 35-43.
DOI
- Thotawatte, N. T., De Silva, H. H. V. K. N., & Rajapaksha, R. G. W. D. B. (2020). Prescription Analysis of short dosage forms of metformin as monotherapy or combined therapy in type II diabetes mellitus; pilot study. CINEC Academic Journal, 4, 59-61.
DOI
- Kangara, K. M. T. D. B., Senanayake, S. D., Siriwardhana, A. K., Maanisha, N. W. A. N., Rathnasekara, G. A. J., De Silva, H. H. V. K. N., & Rajapaksha, R. G. W. D. B. (2022). Analysis of Dispensing Pattern of OTC Drugs in Community Pharmacy Outlets, Sri Lankan Perspectives; A Pilot Study. CINEC Academic Journal, 5(2), 6-10.
DOI
- Senadeera, S. P. N. N., Fernando, K. S. K., Wickramasekara, W. L. L. N., Fernando, M. Y. S., Ranaweera, C. B., Rajapaksha, W., & Silva, A. R. N. (2021). In vitro Anti-inflammatory Activity of Endemic Artocarpus nobilis Thw Found in Sri Lanka. Asian Plant Research Journal, 116-122.
DOI

Year Citation
2025 De Silva, A., Wijekoon, J. L., Liyanarachchi, R., Panchendrarajan, R., & Rajapaksha, W. (2025). AI Insights: A Case Study on Utilizing ChatGPT Intelligence for Research Paper Analysis. In Ceur Workshop Proceedings Vol. 3989 (pp. 66-77).

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