Prof Wayne Hein
School of Animal and Veterinary Science
Faculty of Sciences, Engineering and Technology
Professor Wayne Hein is an adjunct Professor at the University of Adelaide. He was Head of the School of Animal and Veterinary Sciences and Dean of Roseworthy Campus from 2015 until his retirement in September 2022.Coming from a rural background in South Australia, Professor Hein began tertiary education at Roseworthy Agricultural College. He then obtained a degree in veterinary science at the University of Queensland and worked for a few years in veterinary public health before completing a PhD in immunology in the John Curtin School of Medical Research at the Australian National University. Over the next 13 years, he conducted basic research into the immune system of ruminants at the Basel Institute for Immunology, Switzerland. Following a move to New Zealand, his research interests focussed on basic and applied immunoparasitology. From 2007-2010 he was the Director of the Hopkirk Research Institute located at Massey University where research focussed on parasitic and infectious diseases of livestock. From 2011-2014 he was Professor and Head of the School of Veterinary and Biomedical Sciences and Dean of Veterinary Science at James Cook University, Australia. Professor Hein returned to South Australia as Head of the School of Animal and Veterinary Sciences and Dean of Roseworthy Campus at the University of Adelaide in February 2015.Professor Hein has published extensively in basic and applied immunology, participated in numerous scientific advisory and review committees, given presentations at multiple national and international scientific conferences and held company director positions.
Research Interests
Professor Hein has made major contributions to current knowledge about the structure and function of the immune system in ruminants, particularly at the molecular level. His early work focussed on the ontogeny of antigen receptor diversity in both the T and B lymphocyte lineages. During a productive phase of research at the Basel Institute for Immunology, his group cloned and sequenced all genes encoding the T cell receptors of sheep and mapped their sequential expression in different tissues during fetal and post-natal development. Collaborative work established the special role of the Peyer’s patches in generating the circulating B lymphocyte repertoire. Over the past two decades, his work has dealt mainly with immune mechanisms of resistance to gastrointestinal parasites in sheep. Due to other demands, Professor Hein currently has limited opportunities to personally conduct research, however he maintains a linkage to research through supervision of higher degree research students.
Invited Participation in International Conferences
| Year | Conference |
|---|---|
| 2013 | Inaugural International Conference on Research in Veterinary Science, Singapore (Keynote Speaker and Workshop Chair) |
| 2013 | 10th International Veterinary Immunology Symposium, Milan, Italy (Chair of VIC Committee of IUIS with various roles at the Symposium) |
| 2013 | 15th International Congress of Immunology, Milan, Italy (Co-Chair, Veterinary Immunology Workshop) |
| 2013 | Annual Conference of the Australian Veterinary Association, Cairns. (Invited speaker) |
| 2010 | 14th International Congress of Immunology, Kobe, Japan (Co-Chair of Symposium on viral diseases; Co-Chair of Veterinary Immunology Workshop). |
| 2010 | 9th International Veterinary Immunology Symposium, Tokyo, Japan (Chair, Veterinary Immunology Committee) |
| 2009 | 3rd European Veterinary Immunology Workshop, Berlin , Germany (Plenary Speaker) |
| 2006 | International Veterinary Vaccines and Diagnostics Conference, Oslo, Norway. (Symposium Co-Chairman) |
| 2005 | 20th International Conference of the World Association for the Advancement of Veterinary Parasitology, Christchurch, NZ, (Plenary Speaker) |
| 2004 | 7th International Veterinary Immunology Symposium, Quebec City, Canada, 2004 (Plenary Session Co-Chairman and Speaker) |
| 2000 | New Zealand and Australian Societies for Parasitology Combined Conference, Wellington, NZ (Session Co-Chairman and Speaker) |
| 1998 | 5th International Veterinary Immunology Symposium, Ludhiana, India 1998 (Plenary Session Co-Chairman and Speaker) |
| 1996 | International Symposium on Cytokines and the Type I – Type II Paradigm, Cairns, Australia . (Session Chairman and Invited Speaker) |
| 1995 | Second International Symposium of the Sonderforschungsbereich 280, Hannover, Germany. (Invited Speaker) |
| 1994 | XIV International Conference of the International Society for Animal Genetics, Prague, Czech Republic (Invited Speaker) |
| 1994 | 6th International Congress of the Society for Developmental and Comparative Immunology, Waageningen, Holland (Invited Speaker) |
| 1992 | 3rd International Veterinary Immunology Symposium, Budapest, Hungary (Plenary Session Chairman and Invited Speaker) |
Database submissions
Principal (or collaborative) submitting and annotating author for the following cDNA sequences in the GenBank database:
| Species | Gene | Accession No. |
|---|---|---|
| Sheep (Ovis aries) | (MHC class I) | M34672 – M34676 |
| CD3 gamma chain | X52994 | |
| CD3 delta chain | X52993 | |
| CD3 epsilon chain | Z12969 | |
| T cell receptor, invariant zeta chain | Z12968 | |
| T cell receptor, alpha chain, C-region | M55622 | |
| T cell receptor, beta chain, C-regions | M94181 – M94183 | |
| T cell receptor, gamma chain, C-regions | Z12964 – Z12967 | |
| Z13986 | ||
| T cell receptor, delta chain, C-region | Z12963 | |
| T cell receptor, gamma chain, V-regions | Z12998 – Z13007 | |
| T cell receptor, delta chain, V-regions | Z12970 – 12997 | |
| Immunoglobulin heavy chain M, C-region | L04260 | |
| Immunoglobulin light chain kappa, V-regions | AF038133–AF038138 | |
| Immunoglobulin light chain kappa, J-regions | AF038132 | |
| Immunoglobulin light chain lambda, V-regions | AF038139-AF038148 | |
| Complement receptor Type-2 (CD21) | AF038131 | |
| Complement component C3dg | AF038130 | |
| Polyubiquitin | AF038129 | |
| Cattle (Bos taurus) | T cell receptor, gamma chain, V-regions | U73186 – U73188 |
| T cell receptor, delta chain, V-regions | U73380 – U73393 |
Patents
- RAN 4602/25 ‘Lecithin-bile salt mixed micelles as a proliposomal lymphotropic drug carrier’. Inventors: A. Supersaxo, H. Steffen and W. Hein. Filed by Roche Pharmaceutical Research, Basel, Switzerland.
- EP 388 817 B1 ‘Utility of mixed micelle particles and solutions as immunomodulators’. Inventors: A. Supersaxo, H. Steffen and W. Hein. Filed by Roche Pharmaceutical Research, Basel, Switzerland.
- NO 19994456 ‘Purified membrane enclosed particles, method for purification and use’. Inventors: T. Landsverk, P. Collas, W. R. Hein. Filed by T. Landsverk, Oslo, Norway.
- APA 2002950715 ‘Novel monoclonal antibody and nematode larval antigens’. Inventors: G.B.L. Harrison, C.B. Shoemaker, H.D. Pulford, W.R. Hein. Filed by AgResearch Limited, Hamilton, New Zealand.
| Date | Position | Institution name |
|---|---|---|
| 2022 - ongoing | Adjunct Professor | University of Adelaide |
| 2015 - 2022 | Professor and Head of School | University of Adelaide |
| 2015 - 2022 | Dean | University of Adelaide |
| 2011 - 2014 | Professor and Head of School | James Cook University |
| 2011 - 2014 | Dean of Veterniary Science | James Cook University |
| 2011 - 2013 | Director | JCU Univet Pty Ltd |
| 2011 - 2012 | Co-Director | JCU Centre for Biosecurity of Tropical Infectious Diseases |
| 2007 - 2010 | Director | Hopkirk Research Institute |
| 2005 - 2010 | Adjunct Professor | Massey University |
| 2005 - 2010 | Section Manager | AgResearch (New Zealand) |
| 2004 - ongoing | Acting Platform Science Leader | AgResearch (New Zealand) |
| 1998 - 2004 | Science Team Leader | AgResearch (New Zealand) |
| 1985 - 1998 | Scientific Member | Basel Institute for Immunology |
| 1982 - 1985 | Research Scholar | Australian National University |
| 1982 - 1985 | Research Scholar | Australian National University |
| 1980 - 1982 | Lecturer in Meat Inspection | Canberra College of Advanced Education |
| 1978 - 1979 | Lecturer in Meat Inspection | South Australian Institute of Technology |
| 1977 - 1982 | Veterinary Officer | Australian Bureau of Animal Health |
| Date | Type | Title | Institution Name | Country | Amount |
|---|---|---|---|---|---|
| 2013 | Award | Distinguished Service Award | Veterinary Immunology Committee of International Union of Immunological Societies | - | - |
| 2013 | Award | Distinguished Service Award | IUIS Veterinary Immunology Committee | - | - |
| 1995 | Achievement | Welcome Visiting Professor | Washington State University | - | - |
| 1995 | Honour | Welcome Visiting Professor | Washington State University | - | - |
| 1994 | Honour | D.L.T. Smith Visiting Lecturer | University of Saskatchewan | - | - |
| 1994 | Achievement | DLT Smith Visiting Lecturer | University of Saskatchewan | - | - |
| 1991 | Award | Industrial Research Award | - | - | - |
| 1991 | Award | Industrial Research Award | American Association of Pharmaceutical Scientists | United Kingdom | - |
| 1976 | Award | The ICI Australia Prize in Veterinary Preventive Medicine | - | - | - |
| Date | Institution name | Country | Title |
|---|---|---|---|
| 1986 | Australian National University | Australia | Doctor of Philosophy (Immunology) |
| 1976 | University of Queensland | Australia | Bachelor of Veterinary Science (IIA Hons) |
| 1970 | Roseworthy Agricultural College | Australia | Roseworthy Diploma of Agriculture |
| Date | Title | Institution | Country |
|---|---|---|---|
| 2011 | Leadership Program | Harvard Club of Australia | Australia |
| 2008 | Ernst & Young Executive Programme | University of Philadelphia | New Zealand |
| Date | Title | Institution name | Country |
|---|---|---|---|
| — | Certificate in Company Direction | Institute of Directors in New Zealand | New Zealand |
| Year | Citation |
|---|---|
| 2016 | Kenngott, E., Cole, S., Hein, W., Hoffmann, U., Lauer, U., Maass, D., . . . Pernthaner, A. (2016). Identification of Targeting Peptides for Mucosal Delivery in Sheep and Mice. Molecular Pharmaceutics, 13(1), 202-210. Scopus10 WoS9 Europe PMC7 |
| 2014 | Bond, J., Pernthaner, A., Zhang, K., Rosanowski, S., Clerens, S., Bisset, S., . . . Hein, W. (2014). Efferent intestinal lymph protein responses in nematode-resistant, -resilient and -susceptible lambs under challenge with Trichostrongylus colubriformis. Journal of Proteomics, 109, 356-367. Scopus3 WoS3 Europe PMC1 |
| 2013 | Tozaki, K., Kimura, J., Yasuda, M., Ryu, N., Nasu, T., Pernthaner, A., & Hein, W. (2013). C6, a new monoclonal antibody, reacts with the follicle-associated epithelium of calf ileal Peyer's patches. Journal of Veterinary Science, 14(1), 1-6. WoS1 |
| 2012 | Hein, W. R. (2012). Worms and diarrhoea in sheep: a complex interaction. The Veterinary Journal, 192(3), 255-256. |
| 2010 | Knight, J. S., Baird, D. B., Hein, W. R., & Pernthaner, A. (2010). The gastrointestinal nematode Trichostrongylus colubriformis down-regulates immune gene expression in migratory cells in afferent lymph. BMC Immunology, 11(1), 12 pages. Scopus27 WoS25 Europe PMC21 |
| 2010 | Hein, W. R., Pernthaner, A., Piedrafita, D., & Meeusen, E. N. (2010). Immune mechanisms of resistance to gastrointestinal nematode infections in sheep. Parasite Immunology, 32(8), 541-548. Scopus33 WoS32 Europe PMC24 |
| 2010 | Ramírez-Restrepo, C. A., Pernthaner, A., Barry, T. N., López-Villalobos, N., Shaw, R. J., Pomroy, W. E., & Hein, W. R. (2010). Characterization of immune responses against gastrointestinal nematodes in weaned lambs grazing willow fodder blocks. Animal Feed Science and Technology, 155(2-4), 99-110. Scopus24 WoS24 |
| 2009 | Maass, D. R., Harrison, G. B., Grant, W. N., Hein, W. R., & Shoemaker, C. B. (2009). Intraspecific epitopic variation in a carbohydrate antigen exposed on the surface of Trichostrongylus colubriformis infective L3 larvae. Plos Pathogens, 5(9), 9 pages. Scopus15 WoS13 Europe PMC11 |
| 2008 | Harrison, G. B. L., Pulford, H. D., Doolin, E. E., Pernthaner, A., Shoemaker, C. B., & Hein, W. R. (2008). Antibodies to surface epitopes of the carbohydrate larval antigen CarLA are associated with passive protection in strongylid nematode challenge infections. Parasite Immunology, 30(11-12), 577-584. Scopus40 WoS38 Europe PMC30 |
| 2007 | Lefevre, E. A., Hein, W. R., Stamataki, Z., Brackenbury, L. S., Supple, E. A., Hunt, L. G., . . . Charleston, B. (2007). Fibrinogen is localized on dark zone follicular dendritic cells in vivo and enhances the proliferation and survival of a centroblastic cell line in vitro. Journal of Leukocyte Biology, 82(3), 666-677. Scopus10 WoS12 Europe PMC13 |
| 2007 | Harrison, G., Pulford, H., Doolin, L., & Hein, W. (2007). Antibodies to larval surface antigens are protective against <i>Trichostrongylus colubriformis</i> challenge in a sheep passive immunity model. NEW ZEALAND JOURNAL OF ZOOLOGY, 34(2), 145. |
| 2007 | Lefevre, E. A., Hein, W. R., Stamataki, Z., Brackenbury, L. S., Supple, E. A., Hunt, L. G., . . . Charleston, B. (2007). Erratum: Fibrinogin is localized on dark zone follicular dendritic cells in vivo and enhances the proliferation and survival or a centroblastic cell line in vitro (Journal of Leukocyte Biology (2007) 82, 3, (666-677) doi: 10.1189/jlb.0107050). Journal of Leukocyte Biology, 82(5), 1361. Scopus4 WoS2 |
| 2006 | Pernthaner, A., Cole, S. A., Morrison, L., Green, R., Shaw, R. J., & Hein, W. R. (2006). Cytokine and antibody subclass responses in the intestinal lymph of sheep during repeated experimental infections with the nematode parasite Trichostrongylus colubriformis. Veterinary Immunology and Immunopathology, 114(1-2), 135-148. Scopus58 WoS55 Europe PMC44 |
| 2005 | Hein, W. R., & Harrison, G. B. L. (2005). Vaccines against veterinary helminths. Veterinary Parasitology, 132(3-4 SPEC. ISS.), 217-222. Scopus40 WoS39 Europe PMC35 |
| 2005 | Pernthaner, A., Cole, S. A., Morrison, L., & Hein, W. R. (2005). Increased expression of interleukin-5 (IL-5), IL-13, and tumor necrosis factor alpha genes in intestinal lymph cells of sheep selected for enhanced resistance to nematodes during infection with Trichostrongylus colubriformis. Infection and Immunity, 73(4), 2175-2183. Scopus93 WoS87 Europe PMC80 |
| 2005 | Pernthaner, A., Shaw, R. J., McNeill, M. M., Morrison, L., & Hein, W. R. (2005). Total and nematode-specific IgE responses in intestinal lymph of genetically resistant and susceptible sheep during infection with Trichostrongylus colubriformis. Veterinary Immunology and Immunopathology, 104(1-2), 69-80. Scopus42 WoS35 Europe PMC29 |
| 2004 | Hein, W. R., Barber, T., Cole, S. A., Morrison, L., & Pernthaner, A. (2004). Long-term collection and characterization of afferent lymph from the ovine small intestine. Journal of Immunological Methods, 293(1-2), 153-168. Scopus39 WoS37 Europe PMC31 |
| 2003 | Shaw, R. J., McNeill, M. M., Maass, D. R., Hein, W. R., Barber, T. K., Wheeler, M., . . . Shoemaker, C. B. (2003). Identification and characterisation of an aspartyl protease inhibitor homologue as a major allergen of Trichostrongylus colubriformis. International Journal for Parasitology, 33(11), 1233-1243. Scopus45 WoS40 Europe PMC33 |
| 2003 | Harrison, G. B. L., Pulford, H. D., Hein, W. R., Severn, W. B., & Shoemaker, C. B. (2003). Characterization of a 35-kDA carbohydrate larval antigen (CarLA) from Trichostrongylus colubriformis; a potential target for host immunity. Parasite Immunology, 25(2), 79-86. Scopus32 WoS28 Europe PMC25 |
| 2003 | Harrison, G. B. L., Pulford, H. D., Hein, W. R., Barber, T. K., Shaw, R. J., McNeill, M., . . . Shoemaker, C. B. (2003). Immune rejection of Trichostrongylus colubriformis in sheep; a possible role for intestinal mucus antibody against an L3-specific surface antigen. Parasite Immunology, 25(1), 45-53. Scopus53 WoS48 Europe PMC42 |
| 2003 | Hein, W. R., & Griebel, P. J. (2003). A road less travelled: Large animal models in immunological research. Nature Reviews Immunology, 3(1), 79-84. Scopus173 WoS165 Europe PMC140 |
| 2002 | Pernthaner, A., Cole, S. A., Gatehouse, T., & Hein, W. R. (2002). Phenotypic diversity of antigen-presenting cells in ovine-afferent intestinal lymph. Archives of Medical Research, 33(4), 405-412. Scopus17 WoS17 Europe PMC15 |
| 2002 | Harrison, G., Pulford, H., Gatehouse, T., Hein, W., & Shoemaker, C. (2002). Intestinal infusion of soluble larval antigen stimulates rejection of heterologous nematode larvae by immune sheep. Parasitology Research, 88(5), 463-467. Scopus2 WoS1 Europe PMC1 |
| 2002 | Collas, P., Cline, R., Landsverk, H. B., Hein, W. R., Goldsby, R. A., Osborne, B. A., & Landsverk, T. (2002). DNA-containing extracellular 50-nm particles in the ileal Peyer's patch of sheep. European Journal of Cell Biology, 81(2), 69-76. Scopus3 WoS3 Europe PMC4 |
| 2001 | Hein, W. R., Shoemaker, C. B., & Heath, A. C. G. (2001). Future technologies for control of nematodes of sheep. New Zealand Veterinary Journal, 49(6), 247-251. Scopus17 WoS15 Europe PMC10 |
| 2000 | Griebel, P. J., Beskorwayne, T., Godson, D. L., Popowych, Y., & Hein, W. (2000). Cloning non-transformed sheep B cells. Journal of Immunological Methods, 237(1-2), 19-28. Scopus10 WoS8 Europe PMC7 |
| 2000 | Seabrook, T. J., Hein, W. R., Dudler, L., & Young, A. J. (2000). Splenectomy selectively affects the distribution and mobility of the recirculating lymphocyte pool. Blood, 96(3), 1180-1183. Scopus21 WoS20 Europe PMC12 |
| 1999 | Young, A. J., Dudler, L., Yamaguchi, K., Marston, W., & Hein, W. R. (1999). Structure and expression of ovine complement receptor type 2. Veterinary Immunology and Immunopathology, 72(1-2), 67-72. Scopus12 WoS12 Europe PMC11 |
| 1999 | Hein, W. R., & Dudler, L. (1999). Diversification of sheep immunoglobulins. Veterinary Immunology and Immunopathology, 72(1-2), 17-20. Scopus5 WoS3 Europe PMC3 |
| 1999 | Hein, W. R. (1999). Organization of mucosal lymphoid tissue. Current Topics in Microbiology and Immunology, 236, 1-15. Scopus45 WoS39 Europe PMC24 |
| 1998 | Hein, W. R., & Dudler, L. (1998). Diversity of Ig light chain variable region gene expression in fetal lambs. International Immunology, 10(9), 1251-1259. Scopus19 WoS15 Europe PMC13 |
| 1998 | Hein, W. R., Dudler, L., Marston, W. L., Landsverk, T., Young, A. J., & Avila, D. (1998). Ubiquitination and dimerization of complement receptor type 2 on sheep B cells. Journal of Immunology, 161(1), 458-466. Scopus30 WoS30 Europe PMC22 |
| 1997 | Young, A. J., Marston, W. L., Dessing, M., Dudler, L., & Hein, W. R. (1997). Distinct recirculating and non-recirculating B-lymphocyte pools in the peripheral blood are defined by coordinated expression of CD21 and L-selectin. Blood, 90(12), 4865-4875. Scopus60 WoS60 Europe PMC38 |
| 1997 | Hein, W. R., & Dudler, L. (1997). TCR gamma delta(+) cells are prominent in normal bovine skin and express a diverse repertoire of antigen receptors. IMMUNOLOGY, 91(1), 58-64. WoS73 Europe PMC62 |
| 1997 | Hein, W. R., & Dudler, L. (1997). TCR γδ+ cells are prominent in normal bovine skin and express a diverse repetoire of antigen receptors. Immunology, 91(1), 58-64. Scopus74 |
| 1997 | Saini, S. S., Hein, W. R., & Kaushik, A. (1997). A single predominantly expressed polymorphic immunoglobulin V(H) gene family, related to mammalian group, I, clan, II, is identified in cattle. Molecular Immunology, 34(8-9), 641-651. Scopus61 WoS58 Europe PMC47 |
| 1996 | Ferguson, E. D., Dutia, B. M., Hein, W. R., & Hopkins, J. (1996). The sheep CD1 gene family contains at least four CD1B homologues. Immunogenetics, 44(2), 86-96. Scopus22 WoS22 Europe PMC12 |
| 1996 | Hein, W. R. (1996). Inclusion not exclusion.. Australian Veterinary Journal, 73(3), 118. |
| 1996 | Griebel, P. J., & Hein, W. R. (1996). Expanding the role of Peyer's patches in B-cell ontogeny. Immunology Today, 17(1), 30-39. Scopus168 WoS160 Europe PMC125 |
| 1995 | Hein, W. (1995). Sheep as experimental animals for immunological research. Immunologist, 3(1), 12-18. Scopus22 |
| 1995 | Reynaud, C. A., Garcia, C., Hein, W. R., & Weill, J. C. (1995). Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell, 80(1), 115-125. Scopus277 WoS271 Europe PMC209 |
| 1994 | Hein, W. R. (1994). PL.3 Early development of the immune system. Developmental and Comparative Immunology, 18(SUPPL. 1), S36-S37. |
| 1994 | Walker, I. D., Glew, M. D., O'Keeffe, M. A., Metcalfe, S. A., Clevers, H. C., Wijngaard, P. L. J., . . . Hein, W. R. (1994). A novel multi-gene family of sheep γδ T cells. Immunology, 83(4), 517-523. Scopus46 |
| 1994 | CASPAR‐BAUGUIL, S., ARNAUD, J., HUCHENQ, A., HEIN, W. R., GEISLER, C., & RUBIN, B. (1994). A Highly Conserved Phenylalanine in the α, β‐T Cell Receptor (TCR) Constant Region Determines the Integrity of TCR/CD3 Complexes. Scandinavian Journal of Immunology, 40(3), 323-336. Scopus24 WoS22 Europe PMC17 |
| 1994 | WALKER, I. D., GLEW, M. D., OKEEFFE, M. A., METCALFE, S. A., CLEVERS, H. C., WIJNGAARD, P. L. J., . . . HEIN, W. R. (1994). A NOVEL MULTIGENE FAMILY OF SHEEP GAMMA-DELTA T-CELLS. IMMUNOLOGY, 83(4), 517-523. WoS44 Europe PMC29 |
| 1994 | Hein, W. R. (1994). Structural and functional evolution of the extracellular regions of T cell receptors. Seminars in Immunology, 6(6), 361-372. Scopus27 Europe PMC15 |
| 1994 | O'keeffe, M. A., Metcalfe, S. A., Glew, M. D., Bowden, T., Mcinnes, S., Klmpton, W. G., . . . Walker, I. D. (1994). Lymph node homing cells biologically enriched for γδ T cells express multiple genes from the T19 repertoire. International Immunology, 6(11), 1687-1697. Scopus21 WoS20 Europe PMC15 |
| 1993 | Hein, W. R., & Dudler, L. (1993). Nucleotide sequence of the membrane form of sheep IgM and identification of two Cμ allotypes. Molecular Immunology, 30(8), 783-784. Scopus9 WoS8 Europe PMC6 |
| 1993 | Griebel, P., Hein, W. R., Dudler, L., & Ferrari, G. (1993). Phenotype and function of stromal cells cloned from the ileal peyer's patch of sheep. STEM CELLS, 11(2), 130-143. Scopus15 WoS13 Europe PMC12 |
| 1993 | Hein, W. R., & Dudler, L. (1993). Divergent evolution of T cell repertoires: Extensive diversity and developmentally regulated expression of the sheep γδ T cell receptor. EMBO Journal, 12(2), 715-724. Scopus83 WoS85 Europe PMC62 |
| 1993 | Hein, W. R., & Tunnacliffe, A. (1993). Invariant components of the sheep T-cell antigen receptor: cloning of the CD3 ε and Tcr ζ chains. Immunogenetics, 37(4), 279-284. Scopus14 WoS10 Europe PMC12 |
| 1993 | Grossberger, D., Marcuz, A., Fichtel, A., Dudler, L., & Hein, W. R. (1993). Sequence analysis of sheep T-cell receptor β chains. Immunogenetics, 37(3), 222-226. Scopus14 WoS13 Europe PMC9 |
| 1993 | Press, C. M., Hein, W. R., & Landsverk, T. (1993). Ontogeny of leucocyte populations in the spleen of fetal lambs with emphasis on the early prominence of B cells. Immunology, 80(4), 598-604. Scopus36 WoS32 Europe PMC25 |
| 1993 | Hein, W. R. (1993). Viral evasion of host immune defences. British Veterinary Journal, 149(3), 201-203. |
| 1993 | Hein, W. (1993). Molecular basis of antigen recognition. Veterinary Immunology and Immunopathology, 35(SUPPL. 1), 24-27. |
| 1992 | Mackay, C. R., Marston, W. L., Dudler, L., Spertini, O., Tedder, T. F., & Hein, W. R. (1992). Tissue‐specific migration pathways by phenotypically distinct subpopulations of memory T cells. European Journal of Immunology, 22(4), 887-895. Scopus230 WoS238 Europe PMC182 |
| 1992 | Hein, W. R. (1992). Structure and diversity of ruminant T-cell receptors.. Annales de recherches vétérinaires. Annals of veterinary research, 23(3), 262-265. Scopus1 WoS1 |
| 1991 | Supersaxo, A., Hein, W. R., & Steffen, H. (1991). Mixed Micelles as a Proliposomal, Lymphotropic Drug Carrier. Pharmaceutical Research an Official Journal of the American Association of Pharmaceutical Scientists, 8(10), 1286-1291. Scopus34 WoS25 Europe PMC18 |
| 1991 | Hein, W. R., Dudler, L., Marston, W. L., Hopkins, J., Dutia, B. M., Keech, K., . . . Mackay, C. R. (1991). Summary of workshop findings for leukocyte antigens of sheep. Veterinary Immunology and Immunopathology, 27(1-3), 28-30. Scopus15 WoS16 Europe PMC12 |
| 1991 | Hein, W. R., & Mackay, C. R. (1991). Other surface antigens identified on sheep leukocytes. Veterinary Immunology and Immunopathology, 27(1-3), 115-118. Scopus9 WoS8 Europe PMC8 |
| 1991 | Mackay, C. R., & Hein, W. R. (1991). Marked variations in γδ T cell numbers and distribution throughout the life of sheep. Current Topics in Microbiology and Immunology, 173, 107-111. Scopus23 WoS10 Europe PMC14 |
| 1991 | HEIN, W. R., & MACKAY, C. R. (1991). PROMINENCE OF GAMMA-DELTA T-CELLS IN THE RUMINANT IMMUNE-SYSTEM. IMMUNOLOGY TODAY, 12(1), 30-34. WoS439 Europe PMC340 |
| 1991 | Mackay, C. R., Marston, W. L., Dudler, L., & Hein, W. R. (1991). Expression of the "T19" and "null cell" markers on γδT cells of the sheep. Veterinary Immunology and Immunopathology, 27(1-3), 183-188. Scopus16 WoS17 Europe PMC10 |
| 1991 | Hein, W. R., Dudler, L., Beya, M. F., & Mackay, C. R. (1991). Epitopes of the T19 lymphocyte surface antigen are extensively conserved in ruminants. Veterinary Immunology and Immunopathology, 27(1-3), 173-181. Scopus9 WoS12 Europe PMC8 |
| 1991 | Hein, W. R., Marcuz, A., Fichtel, A., Dudler, L., & Grossberger, D. (1991). Primary structure of the sheep T-cell receptor α chain. Immunogenetics, 34(1), 39-41. Scopus18 WoS18 Europe PMC14 |
| 1991 | Landsverk, T., Halleraker, M., Aleksandersen, M., McClure, S., Hein, W., & Nicander, L. (1991). The intestinal habitat for organized lymphoid tissues in ruminants; comparative aspects of structure, function and development. Veterinary Immunology and Immunopathology, 28(1), 1-16. Scopus68 WoS65 Europe PMC46 |
| 1991 | Hein, W. R., & Mackay, C. R. (1991). Prominence of γδ T cells in the ruminant immune system. Immunology Today, 12(1), 30-34. Scopus423 |
| 1990 | Supersaxo, A., Hein, W. R., & Steffen, H. (1990). Effect of Molecular Weight on the Lymphatic Absorption of Water-Soluble Compounds Following Subcutaneous Administration. Pharmaceutical Research an Official Journal of the American Association of Pharmaceutical Scientists, 7(2), 167-169. Scopus360 WoS292 Europe PMC249 |
| 1990 | Aleksandersen, M., Hein, W. R., Landsverk, T., & McClure, S. (1990). Distribution of lymphocyte subsets in the large intestinal lymphoid follicles of lambs. Immunology, 70(3), 391-397. Scopus26 WoS26 Europe PMC21 |
| 1990 | Mackay, C. R., & Hein, W. R. (1990). Analysis of γδ T cells in ruminants reveals further heterogeneity in γδ T-cell features and function among species. Research in Immunology, 141(6), 611-614. Scopus9 WoS9 Europe PMC6 |
| 1990 | Hein, W. R., Dudler, L., & Morris, B. (1990). Differential peripheral expansion and in vivo antigen reactivity of α/β and γ/δ T cells emigrating from the early fetal lamb thymus. European Journal of Immunology, 20(8), 1805-1813. Scopus46 WoS50 Europe PMC41 |
| 1990 | Hein, W. R., Dudler, L., Marcuz, A., & Grossberger, D. (1990). Molecular cloning of sheep T cell receptor γ and δ chain constant regions: unusual primary structure of γ chain hinge segments. European Journal of Immunology, 20(8), 1795-1804. Scopus34 WoS34 Europe PMC25 |
| 1990 | Hein, W. R., & Tunnacliffe, A. (1990). Characterization of the CD3 γ and δ invariant subunits of the sheep T cell antigen receptor. European Journal of Immunology, 20(7), 1505-1511. Scopus13 WoS15 Europe PMC13 |
| 1990 | Grossberger, D., Hein, W., & Marcuz, A. (1990). Class I major histocompatibility complex cDNA clones from sheep thymus: alternative splicing could make a long cytoplasmic tail. Immunogenetics, 32(2), 77-87. Scopus34 WoS35 Europe PMC22 |
| 1989 | Hein, W. R., Dudler, L., Beya, M., Marcuz, A., & Grossberger, D. (1989). T cell receptor gene expression in sheep: differential usage of TcR 1 in the periphery. European Journal of Immunology, 19(12), 2297-2301. Scopus23 WoS24 Europe PMC24 |
| 1989 | Hein, W. R., & Beya, M. F. (1989). Evidence that the B5 molecule on sheep lymphocytes is a homologue of mouse Ly 6 and human CD59. Immunology, 68(4), 580-582. Scopus5 WoS7 Europe PMC6 |
| 1989 | Hein, W. R., Dudler, L., & Mackay, C. R. (1989). Surface expression of differentiation antigens on lymphocytes in the ileal and jejunal Peyer's patches of lambs. Immunology, 68(3), 365-370. Scopus67 WoS67 Europe PMC47 |
| 1989 | McClure, S. J., Hein, W. R., Yamaguchi, K., Dudler, L., Beya, M. F., & Miyasaka, M. (1989). Ontogeny, morphology and tissue distribution of a unique subset of CD4-CD8- sheep T lymphocytes. Immunology and Cell Biology, 67(4), 215-221. Scopus33 WoS38 Europe PMC32 |
| 1989 | McClure, S. J., & Hein, W. R. (1989). Functional characteristics of 197<sup>+</sup> CD4<sup>-</sup> CD8<sup>-</sup> sheep T lymphocytes: expansion and differentiation of peripheral T cells. Immunology and Cell Biology, 67(4), 223-231. Scopus18 WoS18 Europe PMC16 |
| 1989 | Mackay, C. R., & Hein, W. R. (1989). A large proportion of bovine T cells express the γδ T cell receptor and show a distinct tissue distribution and surface phenotype. International Immunology, 1(5), 540-545. Scopus177 Europe PMC153 |
| 1989 | Giegerich, G. W., Hein, W. R., Miyasaka, M., Tiefenthaler, G., & Hunig, T. (1989). Restricted expression of CD2 among subsets of sheep thymocytes and T lymphocytes. Immunology, 66(3), 354-361. Scopus19 WoS17 Europe PMC15 |
| 1989 | Hein, W. R., Shelton, J. N., Simpson-Morgan, M. W., Seamark, R. F., & Morris, B. (1989). Flow and composition of ovarian lymph during pregnancy and luteolysis in the ewe. Animal Reproduction Science, 21(3-4), 223-236. Scopus1 WoS1 |
| 1988 | McClure, S., Dudler, L., Thorpe, D., & Hein, W. R. (1988). Analysis of cell division among subpopulations of lymphoid cells in sheep. II. Peripheral lymphocytes. Immunology, 65(3), 401-404. Scopus10 WoS9 Europe PMC6 |
| 1988 | McClure, S., Dudler, L., Thorpe, D., & Hein, W. R. (1988). Analysis of cell division among subpopulations of lymphoid cells in sheep. I. Thymocytes. Immunology, 65(3), 393-399. Scopus8 WoS11 Europe PMC11 |
| 1988 | Mackay, C. R., Hein, W. R., Brown, M. H., & Matzinger, P. (1988). Unusual expression of CD2 in sheep: implications for T cell interactions. European Journal of Immunology, 18(11), 1681-1688. Scopus102 WoS108 Europe PMC85 |
| 1988 | Supersaxo, A., Hein, W., Gallati, H., & Steffen, H. (1988). Recombinant Human Interferon Alpha-2a: Delivery to Lymphoid Tissue by Selected Modes of Application. Pharmaceutical Research an Official Journal of the American Association of Pharmaceutical Scientists, 5(8), 472-476. Scopus49 WoS35 Europe PMC26 |
| 1988 | Hein, W. R., Shelton, J. N., Simpson-Morgan, M. W., & Morris, B. (1988). Traffic and proliferative responses of recirculating lymphocytes in fetal calves. Immunology, 64(4), 621-626. Scopus12 WoS13 Europe PMC9 |
| 1988 | Hein, W. R., & Supersaxo, A. (1988). Effect of interferon-alpha-2a on the output of recirculating lymphocytes from single lymph nodes. Immunology, 64(3), 469-474. Scopus27 WoS31 Europe PMC17 |
| 1988 | Hein, W. R., Shelton, J. N., Simpson-Morgan, M. W., Seamark, R. F., & Morris, B. (1988). Flow and composition of lymph from the ovary and uterus of cows during pregnancy. Journal of Reproduction and Fertility, 83(1), 309-323. Scopus18 WoS18 Europe PMC13 |
| 1988 | Hein, W. R., McClure, S., Beya, M. F., Dudler, L., & Trnka, Z. (1988). A novel glycoprotein expressed on sheep T and B lymphocytes is involved in a T cell activation pathway. Journal of Immunology, 140(9), 2869-2875. Scopus6 WoS9 Europe PMC6 |
| 1987 | Hein, W. R., McClure, S. J., & Miyasaka, M. (1987). Cellular composition of peripheral lymph and skin of sheep defined by monoclonal antibodies. International Archives of Allergy and Immunology, 84(3), 241-246. Scopus19 WoS21 Europe PMC14 |
| 1981 | Hein, W. R., & Cargill, C. F. (1981). AN ABATTOIR SURVEY OF DISEASES OF FERAL GOATS. Australian Veterinary Journal, 57(11), 498-503. Scopus29 WoS35 Europe PMC16 |
| 1981 | Hein, W. R., & Tomasovic, A. A. (1981). AN ABATTOIR SURVEY OF TUBERCULOSIS IN FERAL BUFFALOES. Australian Veterinary Journal, 57(12), 543-547. Scopus29 WoS31 Europe PMC19 |
| Year | Citation |
|---|---|
| 2016 | Encyclopedia of Immunobiology (2016). (Vol. Volume 1). Academic Press. |
| 2016 | Encyclopedia of Immunobiology (2016). (Vol. Volume 1). Academic Press. |
| Year | Citation |
|---|---|
| 1998 | Obexer-Ruff, G., Fluri, A., Hein, W., Lazary, S., Peterhans, E., & Bertoni, G. (1998). Caprine T-cell receptor variable β-chain (TCRVβ) repertoire analysis and potential applications in cowdriosis immune response studies. In F. Jongejan, W. Goff, & E. Camus (Eds.), Annals of the New York Academy of Sciences Vol. 849 (pp. 321-326). CTR COOPERAT INT RECH AGRONOM DEV, MONTPELLIER, FRANCE: NEW YORK ACAD SCIENCES. DOI Scopus3 WoS1 Europe PMC1 |
| 1991 | MACKAY, C. R., & HEIN, W. R. (1991). MARKED VARIATIONS IN GAMMA-DELTA T-CELL NUMBERS AND DISTRIBUTION THROUGHOUT THE LIFE OF SHEEP. In K. PFEFFER, K. HEEG, H. WAGNER, & G. RIETHMULLER (Eds.), FUNCTION AND SPECIFICITY OF GAMMA/DELTA T CELLS Vol. 173 (pp. 107-111). SCHLOSS ELMAU, FED REP GER: SPRINGER-VERLAG BERLIN. WoS11 |
| Year | Citation |
|---|---|
| 1992 | LANDSVERK, T., PRESS, C., ALEKSANDERSEN, M., HEIN, W., & SIMPSONMORGAN, M. (1992). B-CELL ONTOGENY IN THE SHEEP FETUS. Poster session presented at the meeting of SCANDINAVIAN JOURNAL OF IMMUNOLOGY. BLACKWELL SCIENCE LTD. |
Adjunct teaching experience
- 1980-82 Lecturer in Meat Inspection, Canberra College of Advanced Education
- 1978-79 Lecturer in Meat Inspection, South Australian Institute of Technology
Informal research seminars
University of Berne, University of Zurich, University of Paris, University of Oslo, University of Innsbruck, University of Calgary, Hannover Medical School, Washington State University, University of Saskatchewan, University of Melbourne; Moredun Research Institute, Edinburgh, UK; Babraham Institute, Cambridge, UK; Institute for Animal Health, Compton, UK; International Laboratory for Research in Animal Diseases, Nairobi, Kenya; Wallaceville Animal Research Centre, Upper Hutt, NZ; Malaghan Medical Research Institute, Wellington.
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2017 - 2021 | Co-Supervisor | Understanding the development of gut microbiota and effect of Salmonella Typhimurium infection on gut microbiota in layers | Doctor of Philosophy | Doctorate | Full Time | Dr Nitish Narendra Joat |
| Date | Role | Board name | Institution name | Country |
|---|---|---|---|---|
| 2015 - ongoing | Chair | Board of Directors | Roseworthy Piggery Pty Ltd | Australia |
| 2015 - ongoing | Member | Board of AW Howard Memorial Trust Inc | AW Howard Memorial Trust Inc | - |
| 2015 - ongoing | Member | Academic Board | University of Adelaide | - |
| 2013 - ongoing | Advisory Board Member | Interdisciplinary Program for Biomedical Sciences | Institute for Academic initiatives, Osaka University | Japan |
| Date | Role | Committee | Institution | Country |
|---|---|---|---|---|
| 2014 - ongoing | Chair | External Review Panel - conducting review of clinical training and operation of the teaching hospital | College of Veterinary Medicine, Murdoch University | Australia |
| 2014 - ongoing | Member | Animal Biosecurity RDE Steering Group | Animal Health Australia | - |
| 2012 - ongoing | Chair | External Review Panel (conducting review of preclinical training) | Murdoch University | Australia |
| 2012 - ongoing | Member | Biology and Biotechnology Research Evaluation Committee | Excellence of Research in Australia (ERA), Australian Research Council | Australia |
| 2010 - ongoing | Member | Peer Review Panel of the Danish Council for Strategic Research | - | - |
| 2010 - 2011 | Member | Marsden Fund Ecology Evolution and Behaviour Review Panel | Royal Society of New Zealand | New Zealand |
| 2007 - 2013 | Chair | Veterinary Immunology Committee | Sub-committee of the International Union of Immunological Societies | - |
| 2005 - 2007 | Member | Marsden Fund Biomedical Sciences Review Panel | Royal Society of New Zealand | New Zealand |
| 2003 - 2007 | Member | Scientific Advisory Committee of the Australian Wool Innovation / Meat and Livestock Australia research programme on Functional Genomics of the Host Response to Intestinal Parasites | Meat and Livestock Australia | - |
| 2003 - 2006 | Member | Technical Advisory Group | Animal Health Board of New Zealand | New Zealand |
| 2002 - 2009 | Co-Chair | Veterinary Immunology SIG | Australasian Society for Immunology | - |
| 1997 - ongoing | Member | Invited Member of BBSRC Committee | Babraham Institute | United Kingdom |
| 1996 - ongoing | Member | Invited Member of BBSRC Committee | Institute for Animal Health | United Kingdom |
| Date | Institution | Department | Organisation Type | Country |
|---|---|---|---|---|
| 1995 - ongoing | Moredun Research Institute | - | - | United Kingdom |
| Date | Role | Editorial Board Name | Institution | Country |
|---|---|---|---|---|
| 2015 - ongoing | Editor | The Veterinary Journal | - | - |
| 2014 - 2016 | Editor | Encyclopaedia of Immunobiology | Elsevier | - |
| 2004 - 2012 | Editor | International Journal for Parasitology | - | - |
| 2000 - 2011 | Member | Developmental and Comparative Immunology | - | - |
| 1999 - 2008 | Editor | Veterinary Immunology and Immunopathology | - | - |
| 1992 - ongoing | Member | The Veterinary Journal | - | - |
