Wayne Hein

Wayne Hein

School of Animal and Veterinary Science

Faculty of Sciences, Engineering and Technology

Professor Wayne Hein is an adjunct Professor at the University of Adelaide. He was Head of the School of Animal and Veterinary Sciences and Dean of Roseworthy Campus from 2015 until his retirement in September 2022.

Coming from a rural background in South Australia, Professor Hein began tertiary education at Roseworthy Agricultural College. He then obtained a degree in veterinary science at the University of Queensland and worked for a few years in veterinary public health before completing a PhD in immunology in the John Curtin School of Medical Research at the Australian National University. Over the next 13 years, he conducted basic research into the immune system of ruminants at the Basel Institute for Immunology, Switzerland. Following a move to New Zealand, his research interests focussed on basic and applied immunoparasitology. From 2007-2010 he was the Director of the Hopkirk Research Institute located at Massey University where research focussed on parasitic and infectious diseases of livestock. From 2011-2014 he was Professor and Head of the School of Veterinary and Biomedical Sciences and Dean of Veterinary Science at James Cook University, Australia. Professor Hein returned to South Australia as Head of the School of Animal and Veterinary Sciences and Dean of Roseworthy Campus at the University of Adelaide in February 2015.

Professor Hein has published extensively in basic and applied immunology, participated in numerous scientific advisory and review committees, given presentations at multiple national and international scientific conferences and held company director positions.

Research Interests

Professor Hein has made major contributions to current knowledge about the structure and function of the immune system in ruminants, particularly at the molecular level.  His early work focussed on the ontogeny of antigen receptor diversity in both the T and B lymphocyte lineages.  During a productive phase of research at the Basel Institute for Immunology, his group cloned and sequenced all genes encoding the T cell receptors of sheep and mapped their sequential expression in different tissues during fetal and post-natal development.  Collaborative work established the special role of the Peyer’s patches in generating the circulating B lymphocyte repertoire.  Over the past two decades, his work has dealt mainly with immune mechanisms of resistance to gastrointestinal parasites in sheep.  Due to other demands, Professor Hein currently has limited opportunities to personally conduct research, however he maintains a linkage to research through supervision of higher degree research students.

Invited Participation in International Conferences

Year Conference
2013 Inaugural International Conference on Research in Veterinary Science, Singapore (Keynote Speaker and Workshop Chair)
2013 10th International Veterinary Immunology Symposium, Milan, Italy (Chair of VIC Committee of IUIS with various roles at the Symposium)
2013 15th International Congress of Immunology, Milan, Italy (Co-Chair, Veterinary Immunology Workshop)
2013 Annual Conference of the Australian Veterinary Association, Cairns. (Invited speaker) 
2010 14th International Congress of Immunology, Kobe, Japan (Co-Chair of Symposium on viral diseases; Co-Chair of Veterinary Immunology Workshop).
2010 9th International Veterinary Immunology Symposium, Tokyo, Japan (Chair, Veterinary Immunology Committee)
2009 3rd European Veterinary Immunology Workshop, Berlin , Germany (Plenary Speaker)  
2006 International Veterinary Vaccines and Diagnostics Conference, Oslo, Norway. (Symposium Co-Chairman)
2005 20th International Conference of the World Association for the Advancement of Veterinary Parasitology, Christchurch, NZ, (Plenary Speaker)
2004 7th International Veterinary Immunology Symposium, Quebec City, Canada, 2004 (Plenary Session Co-Chairman and Speaker)
2000 New Zealand and Australian Societies for Parasitology Combined Conference, Wellington, NZ (Session Co-Chairman and Speaker)
1998 5th International Veterinary Immunology Symposium, Ludhiana, India 1998 (Plenary Session Co-Chairman and Speaker)
1996 International Symposium on Cytokines and the Type I – Type II Paradigm, Cairns, Australia . (Session Chairman and Invited Speaker)
1995 Second International Symposium of the Sonderforschungsbereich 280, Hannover, Germany. (Invited Speaker)
1994 XIV International Conference of the International Society for Animal Genetics, Prague, Czech Republic (Invited Speaker)
1994 6th International Congress of the Society for Developmental and Comparative Immunology, Waageningen,  Holland (Invited Speaker)
1992 3rd International Veterinary Immunology Symposium, Budapest, Hungary (Plenary Session Chairman and Invited Speaker)

Database submissions

Principal (or collaborative) submitting and annotating author for the following cDNA sequences in the GenBank database:

Species Gene Accession No.
Sheep (Ovis aries) (MHC class I) M34672 – M34676
  CD3 gamma chain  X52994 
  CD3 delta chain  X52993
  CD3 epsilon chain  Z12969
  T cell receptor, invariant zeta chain  Z12968
  T cell receptor, alpha chain, C-region M55622
  T cell receptor, beta chain, C-regions M94181 – M94183                                             
  T cell receptor, gamma chain, C-regions Z12964 – Z12967
    Z13986
  T cell receptor, delta chain, C-region  Z12963
  T cell receptor, gamma chain, V-regions  Z12998 – Z13007
  T cell receptor, delta chain, V-regions  Z12970 – 12997
  Immunoglobulin heavy chain M, C-region  L04260
  Immunoglobulin light chain kappa, V-regions AF038133–AF038138
  Immunoglobulin light chain kappa, J-regions AF038132
  Immunoglobulin light chain lambda, V-regions AF038139-AF038148
  Complement receptor Type-2 (CD21)  AF038131
  Complement component C3dg AF038130
  Polyubiquitin    AF038129
Cattle (Bos taurus) T cell receptor, gamma chain, V-regions U73186 – U73188
  T cell receptor, delta chain, V-regions U73380 – U73393

Patents

  • RAN 4602/25 ‘Lecithin-bile salt mixed micelles as a proliposomal lymphotropic drug carrier’. Inventors: A. Supersaxo, H. Steffen and W. Hein.  Filed by Roche Pharmaceutical Research, Basel, Switzerland.
  • EP 388 817 B1 ‘Utility of mixed micelle particles and solutions as immunomodulators’. Inventors: A. Supersaxo, H. Steffen and W. Hein. Filed by Roche Pharmaceutical Research, Basel, Switzerland.
  • NO 19994456 ‘Purified membrane enclosed particles, method for purification and use’.  Inventors: T. Landsverk, P. Collas, W. R. Hein.  Filed by T. Landsverk, Oslo, Norway.
  • APA 2002950715 ‘Novel monoclonal antibody and nematode larval antigens’. Inventors: G.B.L. Harrison, C.B. Shoemaker, H.D. Pulford, W.R. Hein.  Filed by AgResearch Limited, Hamilton, New Zealand. 



 

  • Appointments
    Date Position Institution name
    2022 - ongoing Adjunct Professor University of Adelaide
    2015 - 2022 Professor and Head of School University of Adelaide
    2015 - 2022 Dean University of Adelaide
    2011 - 2014 Professor and Head of School James Cook University
    2011 - 2014 Dean of Veterniary Science James Cook University
    2011 - 2013 Director JCU Univet Pty Ltd
    2011 - 2012 Co-Director JCU Centre for Biosecurity of Tropical Infectious Diseases
    2007 - 2010 Director Hopkirk Research Institute
    2005 - 2010 Adjunct Professor Massey University
    2005 - 2010 Section Manager AgResearch (New Zealand)
    2004 - ongoing Acting Platform Science Leader AgResearch (New Zealand)
    1998 - 2004 Science Team Leader AgResearch (New Zealand)
    1985 - 1998 Scientific Member Basel Institute for Immunology
    1982 - 1985 Research Scholar Australian National University
    1982 - 1985 Research Scholar Australian National University
    1980 - 1982 Lecturer in Meat Inspection Canberra College of Advanced Education
    1978 - 1979 Lecturer in Meat Inspection South Australian Institute of Technology
    1977 - 1982 Veterinary Officer Australian Bureau of Animal Health

  • Awards and Achievements
    Date Type Title Institution Name Country Amount
    2013 Award Distinguished Service Award Veterinary Immunology Committee of International Union of Immunological Societies - -
    2013 Award Distinguished Service Award IUIS Veterinary Immunology Committee - -
    1995 Achievement Welcome Visiting Professor Washington State University - -
    1995 Honour Welcome Visiting Professor Washington State University - -
    1994 Honour D.L.T. Smith Visiting Lecturer University of Saskatchewan - -
    1994 Achievement DLT Smith Visiting Lecturer University of Saskatchewan - -
    1991 Award Industrial Research Award - - -
    1991 Award Industrial Research Award American Association of Pharmaceutical Scientists United Kingdom -
    1976 Award The ICI Australia Prize in Veterinary Preventive Medicine - - -

  • Education
    Date Institution name Country Title
    1986 Australian National University Australia Doctor of Philosophy (Immunology)
    1976 University of Queensland Australia Bachelor of Veterinary Science (IIA Hons)
    1970 Roseworthy Agricultural College Australia Roseworthy Diploma of Agriculture

  • Postgraduate Training
    Date Title Institution Country
    2011 Leadership Program Harvard Club of Australia Australia
    2008 Ernst & Young Executive Programme University of Philadelphia New Zealand

  • Certifications
    Date Title Institution name Country
    — Certificate in Company Direction Institute of Directors in New Zealand New Zealand

  • Research Interests
    Veterinary Immunology Veterinary Parasitology

  • Journals
    Year Citation
    2016 Kenngott, E., Cole, S., Hein, W., Hoffmann, U., Lauer, U., Maass, D., . . . Pernthaner, A. (2016). Identification of Targeting Peptides for Mucosal Delivery in Sheep and Mice. Molecular Pharmaceutics, 13(1), 202-210.
    DOI Scopus10 Europe PMC5
    2014 Bond, J., Pernthaner, A., Zhang, K., Rosanowski, S., Clerens, S., Bisset, S., . . . Hein, W. (2014). Efferent intestinal lymph protein responses in nematode-resistant, -resilient and -susceptible lambs under challenge with Trichostrongylus colubriformis. Journal of Proteomics, 109, 356-367.
    DOI Scopus3 WoS3 Europe PMC1
    2013 Tozaki, K., Kimura, J., Yasuda, M., Ryu, N., Nasu, T., Pernthaner, A., & Hein, W. (2013). C6, a new monoclonal antibody, reacts with the follicle-associated epithelium of calf ileal Peyer's patches. Journal of Veterinary Science, 14(1), 1-6.
    DOI WoS1
    2012 Hein, W. R. (2012). Worms and diarrhoea in sheep: a complex interaction. The Veterinary Journal, 192(3), 255-256.
    DOI
    2010 Knight, J. S., Baird, D. B., Hein, W. R., & Pernthaner, A. (2010). The gastrointestinal nematode Trichostrongylus colubriformis down-regulates immune gene expression in migratory cells in afferent lymph. BMC Immunology, 11(1), 12 pages.
    DOI Scopus24 WoS21 Europe PMC15
    2010 Hein, W. R., Pernthaner, A., Piedrafita, D., & Meeusen, E. N. (2010). Immune mechanisms of resistance to gastrointestinal nematode infections in sheep. Parasite Immunology, 32(8), 541-548.
    DOI Scopus32 WoS30 Europe PMC17
    2010 Ramírez-Restrepo, C. A., Pernthaner, A., Barry, T. N., López-Villalobos, N., Shaw, R. J., Pomroy, W. E., & Hein, W. R. (2010). Characterization of immune responses against gastrointestinal nematodes in weaned lambs grazing willow fodder blocks. Animal Feed Science and Technology, 155(2-4), 99-110.
    DOI Scopus24 WoS23
    2009 Maass, D. R., Harrison, G. B., Grant, W. N., Hein, W. R., & Shoemaker, C. B. (2009). Intraspecific epitopic variation in a carbohydrate antigen exposed on the surface of Trichostrongylus colubriformis infective L3 larvae. PLoS Pathogens, 5(9), 9 pages.
    DOI Scopus15 WoS13 Europe PMC8
    2008 Harrison, G. B. L., Pulford, H. D., Doolin, E. E., Pernthaner, A., Shoemaker, C. B., & Hein, W. R. (2008). Antibodies to surface epitopes of the carbohydrate larval antigen CarLA are associated with passive protection in strongylid nematode challenge infections. Parasite Immunology, 30(11-12), 577-584.
    DOI Scopus38 WoS34 Europe PMC21
    2007 Lefevre, E. A., Hein, W. R., Stamataki, Z., Brackenbury, L. S., Supple, E. A., Hunt, L. G., . . . Charleston, B. (2007). Fibrinogen is localized on dark zone follicular dendritic cells in vivo and enhances the proliferation and survival of a centroblastic cell line in vitro. Journal of Leukocyte Biology, 82(3), 666-677.
    DOI Scopus10 WoS12 Europe PMC11
    2007 Harrison, G., Pulford, H., Doolin, L., & Hein, W. (2007). Antibodies to larval surface antigens are protective against <i>Trichostrongylus colubriformis</i> challenge in a sheep passive immunity model. NEW ZEALAND JOURNAL OF ZOOLOGY, 34(2), 145.
    2007 Lefevre, E. A., Hein, W. R., Stamataki, Z., Brackenbury, L. S., Supple, E. A., Hunt, L. G., . . . Charleston, B. (2007). Erratum: Fibrinogin is localized on dark zone follicular dendritic cells in vivo and enhances the proliferation and survival or a centroblastic cell line in vitro (Journal of Leukocyte Biology (2007) 82, 3, (666-677) doi: 10.1189/jlb.0107050). Journal of Leukocyte Biology, 82(5), 1361.
    DOI Scopus4 WoS2
    2006 Pernthaner, A., Cole, S. A., Morrison, L., Green, R., Shaw, R. J., & Hein, W. R. (2006). Cytokine and antibody subclass responses in the intestinal lymph of sheep during repeated experimental infections with the nematode parasite Trichostrongylus colubriformis. Veterinary Immunology and Immunopathology, 114(1-2), 135-148.
    DOI Scopus54 WoS51 Europe PMC34
    2005 Hein, W. R., & Harrison, G. B. L. (2005). Vaccines against veterinary helminths. Veterinary Parasitology, 132(3-4 SPEC. ISS.), 217-222.
    DOI Scopus40 WoS39 Europe PMC32
    2005 Pernthaner, A., Cole, S. A., Morrison, L., & Hein, W. R. (2005). Increased expression of interleukin-5 (IL-5), IL-13, and tumor necrosis factor alpha genes in intestinal lymph cells of sheep selected for enhanced resistance to nematodes during infection with Trichostrongylus colubriformis. Infection and Immunity, 73(4), 2175-2183.
    DOI Scopus91 WoS83 Europe PMC66
    2005 Pernthaner, A., Shaw, R. J., McNeill, M. M., Morrison, L., & Hein, W. R. (2005). Total and nematode-specific IgE responses in intestinal lymph of genetically resistant and susceptible sheep during infection with Trichostrongylus colubriformis. Veterinary Immunology and Immunopathology, 104(1-2), 69-80.
    DOI Scopus42 WoS33 Europe PMC23
    2004 Hein, W. R., Barber, T., Cole, S. A., Morrison, L., & Pernthaner, A. (2004). Long-term collection and characterization of afferent lymph from the ovine small intestine. Journal of Immunological Methods, 293(1-2), 153-168.
    DOI Scopus39 WoS37 Europe PMC29
    2003 Shaw, R. J., McNeill, M. M., Maass, D. R., Hein, W. R., Barber, T. K., Wheeler, M., . . . Shoemaker, C. B. (2003). Identification and characterisation of an aspartyl protease inhibitor homologue as a major allergen of Trichostrongylus colubriformis. International Journal for Parasitology, 33(11), 1233-1243.
    DOI Scopus44 WoS38 Europe PMC25
    2003 Harrison, G. B. L., Pulford, H. D., Hein, W. R., Severn, W. B., & Shoemaker, C. B. (2003). Characterization of a 35-kDA carbohydrate larval antigen (CarLA) from Trichostrongylus colubriformis; a potential target for host immunity. Parasite Immunology, 25(2), 79-86.
    DOI Scopus29 WoS25 Europe PMC19
    2003 Harrison, G. B. L., Pulford, H. D., Hein, W. R., Barber, T. K., Shaw, R. J., McNeill, M., . . . Shoemaker, C. B. (2003). Immune rejection of Trichostrongylus colubriformis in sheep; a possible role for intestinal mucus antibody against an L3-specific surface antigen. Parasite Immunology, 25(1), 45-53.
    DOI Scopus50 WoS45 Europe PMC32
    2003 Hein, W. R., & Griebel, P. J. (2003). A road less travelled: Large animal models in immunological research. Nature Reviews Immunology, 3(1), 79-84.
    DOI Scopus170 WoS157 Europe PMC122
    2002 Pernthaner, A., Cole, S. A., Gatehouse, T., & Hein, W. R. (2002). Phenotypic diversity of antigen-presenting cells in ovine-afferent intestinal lymph. Archives of Medical Research, 33(4), 405-412.
    DOI Scopus17 WoS17 Europe PMC15
    2002 Harrison, G., Pulford, H., Gatehouse, T., Hein, W., & Shoemaker, C. (2002). Intestinal infusion of soluble larval antigen stimulates rejection of heterologous nematode larvae by immune sheep. Parasitology Research, 88(5), 463-467.
    DOI Scopus2 WoS1 Europe PMC1
    2002 Collas, P., Cline, R., Landsverk, H. B., Hein, W. R., Goldsby, R. A., Osborne, B. A., & Landsverk, T. (2002). DNA-containing extracellular 50-nm particles in the ileal Peyer's patch of sheep. European Journal of Cell Biology, 81(2), 69-76.
    DOI Scopus3 WoS3 Europe PMC4
    2001 Hein, W. R., Shoemaker, C. B., & Heath, A. C. G. (2001). Future technologies for control of nematodes of sheep. New Zealand Veterinary Journal, 49(6), 247-251.
    DOI Scopus17 WoS15 Europe PMC10
    2000 Griebel, P. J., Beskorwayne, T., Godson, D. L., Popowych, Y., & Hein, W. (2000). Cloning non-transformed sheep B cells. Journal of Immunological Methods, 237(1-2), 19-28.
    DOI Scopus10 WoS8 Europe PMC4
    2000 Seabrook, T. J., Hein, W. R., Dudler, L., & Young, A. J. (2000). Splenectomy selectively affects the distribution and mobility of the recirculating lymphocyte pool. Blood, 96(3), 1180-1183.
    DOI Scopus21 WoS20 Europe PMC12
    1999 Young, A. J., Dudler, L., Yamaguchi, K., Marston, W., & Hein, W. R. (1999). Structure and expression of ovine complement receptor type 2. Veterinary Immunology and Immunopathology, 72(1-2), 67-72.
    DOI Scopus12 WoS12 Europe PMC10
    1999 Hein, W. R., & Dudler, L. (1999). Diversification of sheep immunoglobulins. Veterinary Immunology and Immunopathology, 72(1-2), 17-20.
    DOI Scopus5 WoS3 Europe PMC3
    1999 Hein, W. R. (1999). Organization of mucosal lymphoid tissue. Current Topics in Microbiology and Immunology, 236, 1-15.
    DOI Scopus42 WoS37 Europe PMC20
    1998 Hein, W. R., & Dudler, L. (1998). Diversity of Ig light chain variable region gene expression in fetal lambs. International Immunology, 10(9), 1251-1259.
    DOI Scopus19 WoS15 Europe PMC12
    1998 Hein, W. R., Dudler, L., Marston, W. L., Landsverk, T., Young, A. J., & Avila, D. (1998). Ubiquitination and dimerization of complement receptor type 2 on sheep B cells. Journal of Immunology, 161(1), 458-466.
    Scopus30 WoS29 Europe PMC23
    1997 Young, A. J., Marston, W. L., Dessing, M., Dudler, L., & Hein, W. R. (1997). Distinct recirculating and non-recirculating B-lymphocyte pools in the peripheral blood are defined by coordinated expression of CD21 and L-selectin. Blood, 90(12), 4865-4875.
    DOI Scopus55 WoS54 Europe PMC39
    1997 Hein, W. R., & Dudler, L. (1997). TCR gamma delta(+) cells are prominent in normal bovine skin and express a diverse repertoire of antigen receptors. IMMUNOLOGY, 91(1), 58-64.
    DOI WoS69 Europe PMC53
    1997 Hein, W., & Dudler, L. (1997). TCR γδ<sup>+</sup> cells are prominent in normal bovine skin and express a diverse repetoire of antigen receptors. Immunology, 91(1), 58-64.
    DOI Scopus70
    1997 Saini, S. S., Hein, W. R., & Kaushik, A. (1997). A single predominantly expressed polymorphic immunoglobulin V(H) gene family, related to mammalian group, I, clan, II, is identified in cattle. Molecular Immunology, 34(8-9), 641-651.
    DOI Scopus59 WoS54 Europe PMC40
    1996 Ferguson, E. D., Dutia, B. M., Hein, W. R., & Hopkins, J. (1996). The sheep CD1 gene family contains at least four CD1B homologues. Immunogenetics, 44(2), 86-96.
    DOI Scopus22 WoS22 Europe PMC12
    1996 Hein, W. R. (1996). Inclusion not exclusion.. Australian veterinary journal, 73(3), 118.
    DOI
    1996 Griebel, P. J., & Hein, W. R. (1996). Expanding the role of Peyer's patches in B-cell ontogeny. Immunology Today, 17(1), 30-39.
    DOI Scopus168 WoS159 Europe PMC114
    1995 Hein, W. (1995). Sheep as experimental animals for immunological research. Immunologist, 3(1), 12-18.
    Scopus21
    1995 Reynaud, C. A., Garcia, C., Hein, W. R., & Weill, J. C. (1995). Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell, 80(1), 115-125.
    DOI Scopus273 WoS266 Europe PMC181
    1994 Hein, W. R. (1994). PL.3 Early development of the immune system. Developmental and Comparative Immunology, 18(SUPPL. 1), S36-S37.
    DOI
    1994 Walker, I. D., Glew, M. D., O'Keeffe, M. A., Metcalfe, S. A., Clevers, H. C., Wijngaard, P. L. J., . . . Hein, W. R. (1994). A novel multi-gene family of sheep γδ T cells. Immunology, 83(4), 517-523.
    Scopus46
    1994 CASPAR‐BAUGUIL, S., ARNAUD, J., HUCHENQ, A., HEIN, W. R., GEISLER, C., & RUBIN, B. (1994). A Highly Conserved Phenylalanine in the α, β‐T Cell Receptor (TCR) Constant Region Determines the Integrity of TCR/CD3 Complexes. Scandinavian Journal of Immunology, 40(3), 323-336.
    DOI Scopus24 WoS22 Europe PMC14
    1994 WALKER, I. D., GLEW, M. D., OKEEFFE, M. A., METCALFE, S. A., CLEVERS, H. C., WIJNGAARD, P. L. J., . . . HEIN, W. R. (1994). A NOVEL MULTIGENE FAMILY OF SHEEP GAMMA-DELTA T-CELLS. IMMUNOLOGY, 83(4), 517-523.
    WoS44 Europe PMC21
    1994 Hein, W. R. (1994). Structural and functional evolution of the extracellular regions of T cell receptors. Seminars in Immunology, 6(6), 361-372.
    DOI Scopus27 Europe PMC12
    1994 O'keeffe, M. A., Metcalfe, S. A., Glew, M. D., Bowden, T., Mcinnes, S., Klmpton, W. G., . . . Walker, I. D. (1994). Lymph node homing cells biologically enriched for γδ T cells express multiple genes from the T19 repertoire. International Immunology, 6(11), 1687-1697.
    DOI Scopus21 WoS20 Europe PMC13
    1993 Hein, W. R., & Dudler, L. (1993). Nucleotide sequence of the membrane form of sheep IgM and identification of two Cμ allotypes. Molecular Immunology, 30(8), 783-784.
    DOI Scopus9 WoS8 Europe PMC6
    1993 Griebel, P., Hein, W. R., Dudler, L., & Ferrari, G. (1993). Phenotype and function of stromal cells cloned from the ileal peyer's patch of sheep. STEM CELLS, 11(2), 130-143.
    DOI Scopus15 WoS13 Europe PMC12
    1993 Hein, W. R., & Dudler, L. (1993). Divergent evolution of T cell repertoires: Extensive diversity and developmentally regulated expression of the sheep γδ T cell receptor. EMBO Journal, 12(2), 715-724.
    DOI Scopus83 WoS84 Europe PMC53
    1993 Hein, W. R., & Tunnacliffe, A. (1993). Invariant components of the sheep T-cell antigen receptor: cloning of the CD3 ε and Tcr ζ chains. Immunogenetics, 37(4), 279-284.
    DOI Scopus14 WoS10 Europe PMC11
    1993 Grossberger, D., Marcuz, A., Fichtel, A., Dudler, L., & Hein, W. R. (1993). Sequence analysis of sheep T-cell receptor β chains. Immunogenetics, 37(3), 222-226.
    DOI Scopus14 WoS12 Europe PMC8
    1993 Press, C. M., Hein, W. R., & Landsverk, T. (1993). Ontogeny of leucocyte populations in the spleen of fetal lambs with emphasis on the early prominence of B cells. Immunology, 80(4), 598-604.
    Scopus36 WoS32 Europe PMC25
    1993 Hein, W. R. (1993). Viral evasion of host immune defences. British Veterinary Journal, 149(3), 201-203.
    DOI
    1993 Hein, W. (1993). Molecular basis of antigen recognition. Veterinary Immunology and Immunopathology, 35(SUPPL. 1), 24-27.
    DOI
    1992 Mackay, C. R., Marston, W. L., Dudler, L., Spertini, O., Tedder, T. F., & Hein, W. R. (1992). Tissue‐specific migration pathways by phenotypically distinct subpopulations of memory T cells. European Journal of Immunology, 22(4), 887-895.
    DOI Scopus230 WoS238 Europe PMC167
    1992 Hein, W. R. (1992). Structure and diversity of ruminant T-cell receptors.. Annales de recherches vétérinaires. Annals of veterinary research, 23(3), 262-265.
    Scopus1 WoS1
    1991 Supersaxo, A., Hein, W. R., & Steffen, H. (1991). Mixed Micelles as a Proliposomal, Lymphotropic Drug Carrier. Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists, 8(10), 1286-1291.
    DOI Scopus33 WoS24 Europe PMC16
    1991 Hein, W. R., Dudler, L., Marston, W. L., Hopkins, J., Dutia, B. M., Keech, K., . . . Mackay, C. R. (1991). Summary of workshop findings for leukocyte antigens of sheep. Veterinary Immunology and Immunopathology, 27(1-3), 28-30.
    DOI Scopus15 WoS16 Europe PMC11
    1991 Hein, W. R., & Mackay, C. R. (1991). Other surface antigens identified on sheep leukocytes. Veterinary Immunology and Immunopathology, 27(1-3), 115-118.
    DOI Scopus9 WoS8 Europe PMC7
    1991 Mackay, C. R., & Hein, W. R. (1991). Marked variations in γδ T cell numbers and distribution throughout the life of sheep. Current Topics in Microbiology and Immunology, 173, 107-111.
    DOI Scopus23 WoS9 Europe PMC11
    1991 HEIN, W. R., & MACKAY, C. R. (1991). PROMINENCE OF GAMMA-DELTA T-CELLS IN THE RUMINANT IMMUNE-SYSTEM. IMMUNOLOGY TODAY, 12(1), 30-34.
    DOI WoS428 Europe PMC293
    1991 Mackay, C. R., Marston, W. L., Dudler, L., & Hein, W. R. (1991). Expression of the "T19" and "null cell" markers on γδT cells of the sheep. Veterinary Immunology and Immunopathology, 27(1-3), 183-188.
    DOI Scopus16 WoS17 Europe PMC8
    1991 Hein, W. R., Dudler, L., Beya, M. F., & Mackay, C. R. (1991). Epitopes of the T19 lymphocyte surface antigen are extensively conserved in ruminants. Veterinary Immunology and Immunopathology, 27(1-3), 173-181.
    DOI Scopus9 WoS12 Europe PMC8
    1991 Hein, W. R., Marcuz, A., Fichtel, A., Dudler, L., & Grossberger, D. (1991). Primary structure of the sheep T-cell receptor α chain. Immunogenetics, 34(1), 39-41.
    DOI Scopus18 WoS18 Europe PMC14
    1991 Landsverk, T., Halleraker, M., Aleksandersen, M., McClure, S., Hein, W., & Nicander, L. (1991). The intestinal habitat for organized lymphoid tissues in ruminants; comparative aspects of structure, function and development. Veterinary Immunology and Immunopathology, 28(1), 1-16.
    DOI Scopus67 WoS65 Europe PMC37
    1991 Hein, W. R., & Mackay, C. R. (1991). Prominence of γδ T cells in the ruminant immune system. Immunology Today, 12(1), 30-34.
    DOI Scopus417
    1990 Supersaxo, A., Hein, W. R., & Steffen, H. (1990). Effect of Molecular Weight on the Lymphatic Absorption of Water-Soluble Compounds Following Subcutaneous Administration. Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists, 7(2), 167-169.
    DOI Scopus326 WoS253 Europe PMC181
    1990 Aleksandersen, M., Hein, W. R., Landsverk, T., & McClure, S. (1990). Distribution of lymphocyte subsets in the large intestinal lymphoid follicles of lambs. Immunology, 70(3), 391-397.
    Scopus26 WoS26 Europe PMC20
    1990 Mackay, C. R., & Hein, W. R. (1990). Analysis of γδ T cells in ruminants reveals further heterogeneity in γδ T-cell features and function among species. Research in Immunology, 141(6), 611-614.
    DOI Scopus9 WoS9 Europe PMC5
    1990 Hein, W. R., Dudler, L., & Morris, B. (1990). Differential peripheral expansion and in vivo antigen reactivity of α/β and γ/δ T cells emigrating from the early fetal lamb thymus. European Journal of Immunology, 20(8), 1805-1813.
    DOI Scopus46 WoS49 Europe PMC39
    1990 Hein, W. R., Dudler, L., Marcuz, A., & Grossberger, D. (1990). Molecular cloning of sheep T cell receptor γ and δ chain constant regions: unusual primary structure of γ chain hinge segments. European Journal of Immunology, 20(8), 1795-1804.
    DOI Scopus34 WoS33 Europe PMC23
    1990 Hein, W. R., & Tunnacliffe, A. (1990). Characterization of the CD3 γ and δ invariant subunits of the sheep T cell antigen receptor. European Journal of Immunology, 20(7), 1505-1511.
    DOI Scopus12 WoS15 Europe PMC12
    1990 Grossberger, D., Hein, W., & Marcuz, A. (1990). Class I major histocompatibility complex cDNA clones from sheep thymus: alternative splicing could make a long cytoplasmic tail. Immunogenetics, 32(2), 77-87.
    DOI Scopus32 WoS35 Europe PMC22
    1989 Hein, W. R., Dudler, L., Beya, M., Marcuz, A., & Grossberger, D. (1989). T cell receptor gene expression in sheep: differential usage of TcR 1 in the periphery. European Journal of Immunology, 19(12), 2297-2301.
    DOI Scopus23 WoS24 Europe PMC22
    1989 Hein, W. R., & Beya, M. F. (1989). Evidence that the B5 molecule on sheep lymphocytes is a homologue of mouse Ly 6 and human CD59. Immunology, 68(4), 580-582.
    Scopus5 WoS7 Europe PMC6
    1989 Hein, W. R., Dudler, L., & Mackay, C. R. (1989). Surface expression of differentiation antigens on lymphocytes in the ileal and jejunal Peyer's patches of lambs. Immunology, 68(3), 365-370.
    Scopus67 WoS67 Europe PMC44
    1989 McClure, S. J., Hein, W. R., Yamaguchi, K., Dudler, L., Beya, M. F., & Miyasaka, M. (1989). Ontogeny, morphology and tissue distribution of a unique subset of CD4<sup>-</sup>CD8<sup>-</sup> sheep T lymphocytes. Immunology and Cell Biology, 67(4), 215-221.
    DOI Scopus33 WoS35 Europe PMC31
    1989 McClure, S. J., & Hein, W. R. (1989). Functional characteristics of 197<sup>+</sup> CD4<sup>-</sup> CD8<sup>-</sup> sheep T lymphocytes: expansion and differentiation of peripheral T cells. Immunology and Cell Biology, 67(4), 223-231.
    DOI Scopus18 WoS18 Europe PMC16
    1989 Mackay, C. R., & Hein, W. R. (1989). A large proportion of bovine T cells express the γδ T cell receptor and show a distinct tissue distribution and surface phenotype. International Immunology, 1(5), 540-545.
    DOI Scopus173 Europe PMC127
    1989 Giegerich, G. W., Hein, W. R., Miyasaka, M., Tiefenthaler, G., & Hunig, T. (1989). Restricted expression of CD2 among subsets of sheep thymocytes and T lymphocytes. Immunology, 66(3), 354-361.
    Scopus19 WoS17 Europe PMC14
    1989 Hein, W. R., Shelton, J. N., Simpson-Morgan, M. W., Seamark, R. F., & Morris, B. (1989). Flow and composition of ovarian lymph during pregnancy and luteolysis in the ewe. Animal Reproduction Science, 21(3-4), 223-236.
    DOI Scopus1 WoS1
    1988 McClure, S., Dudler, L., Thorpe, D., & Hein, W. R. (1988). Analysis of cell division among subpopulations of lymphoid cells in sheep. II. Peripheral lymphocytes. Immunology, 65(3), 401-404.
    Scopus10 WoS9 Europe PMC6
    1988 McClure, S., Dudler, L., Thorpe, D., & Hein, W. R. (1988). Analysis of cell division among subpopulations of lymphoid cells in sheep. I. Thymocytes. Immunology, 65(3), 393-399.
    Scopus8 WoS11 Europe PMC10
    1988 Mackay, C. R., Hein, W. R., Brown, M. H., & Matzinger, P. (1988). Unusual expression of CD2 in sheep: implications for T cell interactions. European Journal of Immunology, 18(11), 1681-1688.
    DOI Scopus102 WoS107 Europe PMC79
    1988 Supersaxo, A., Hein, W., Gallati, H., & Steffen, H. (1988). Recombinant Human Interferon Alpha-2a: Delivery to Lymphoid Tissue by Selected Modes of Application. Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists, 5(8), 472-476.
    DOI Scopus47 WoS35 Europe PMC25
    1988 Hein, W. R., Shelton, J. N., Simpson-Morgan, M. W., & Morris, B. (1988). Traffic and proliferative responses of recirculating lymphocytes in fetal calves. Immunology, 64(4), 621-626.
    Scopus12 WoS13 Europe PMC9
    1988 Hein, W. R., & Supersaxo, A. (1988). Effect of interferon-alpha-2a on the output of recirculating lymphocytes from single lymph nodes. Immunology, 64(3), 469-474.
    Scopus26 WoS29 Europe PMC15
    1988 Hein, W. R., Shelton, J. N., Simpson-Morgan, M. W., Seamark, R. F., & Morris, B. (1988). Flow and composition of lymph from the ovary and uterus of cows during pregnancy. Journal of Reproduction and Fertility, 83(1), 309-323.
    DOI Scopus18 WoS18 Europe PMC12
    1988 Hein, W. R., McClure, S., Beya, M. F., Dudler, L., & Trnka, Z. (1988). A novel glycoprotein expressed on sheep T and B lymphocytes is involved in a T cell activation pathway. Journal of Immunology, 140(9), 2869-2875.
    Scopus6 WoS8 Europe PMC7
    1987 Hein, W. R., McClure, S. J., & Miyasaka, M. (1987). Cellular composition of peripheral lymph and skin of sheep defined by monoclonal antibodies. International Archives of Allergy and Immunology, 84(3), 241-246.
    DOI Scopus19 WoS21 Europe PMC11
    1981 Hein, W. R., & Cargill, C. F. (1981). AN ABATTOIR SURVEY OF DISEASES OF FERAL GOATS. Australian Veterinary Journal, 57(11), 498-503.
    DOI Scopus28 WoS32 Europe PMC15
    1981 Hein, W. R., & Tomasovic, A. A. (1981). AN ABATTOIR SURVEY OF TUBERCULOSIS IN FERAL BUFFALOES. Australian Veterinary Journal, 57(12), 543-547.
    DOI Scopus28 WoS31 Europe PMC18

  • Books
    Year Citation
    2016 Encyclopedia of Immunobiology (2016). (Vol. Volume 1). Academic Press.
    2016 Encyclopedia of Immunobiology (2016). (Vol. Volume 1). Academic Press.

  • Conference Papers
    Year Citation
    1998 Obexer-Ruff, G., Fluri, A., Hein, W., Lazary, S., Peterhans, E., & Bertoni, G. (1998). Caprine T-cell receptor variable β-chain (TCRVβ) repertoire analysis and potential applications in cowdriosis immune response studies. In F. Jongejan, W. Goff, & E. Camus (Eds.), Annals of the New York Academy of Sciences Vol. 849 (pp. 321-326). CTR COOPERAT INT RECH AGRONOM DEV, MONTPELLIER, FRANCE: NEW YORK ACAD SCIENCES.
    DOI Scopus3 WoS1
    1991 MACKAY, C. R., & HEIN, W. R. (1991). MARKED VARIATIONS IN GAMMA-DELTA T-CELL NUMBERS AND DISTRIBUTION THROUGHOUT THE LIFE OF SHEEP. In K. PFEFFER, K. HEEG, H. WAGNER, & G. RIETHMULLER (Eds.), FUNCTION AND SPECIFICITY OF GAMMA/DELTA T CELLS Vol. 173 (pp. 107-111). SCHLOSS ELMAU, FED REP GER: SPRINGER-VERLAG BERLIN.
    WoS11

  • Conference Items
    Year Citation
    1992 LANDSVERK, T., PRESS, C., ALEKSANDERSEN, M., HEIN, W., & SIMPSONMORGAN, M. (1992). B-CELL ONTOGENY IN THE SHEEP FETUS. Poster session presented at the meeting of SCANDINAVIAN JOURNAL OF IMMUNOLOGY. BLACKWELL SCIENCE LTD.

Adjunct teaching experience

  • 1980-82    Lecturer in Meat Inspection, Canberra College of Advanced Education
  • 1978-79    Lecturer in Meat Inspection, South Australian Institute of Technology

Informal research seminars

University of Berne, University of Zurich, University of Paris, University of Oslo, University of Innsbruck, University of Calgary, Hannover Medical School, Washington State University, University of Saskatchewan, University of Melbourne; Moredun Research Institute, Edinburgh, UK; Babraham Institute, Cambridge, UK; Institute for Animal Health, Compton, UK; International Laboratory for Research in Animal Diseases, Nairobi, Kenya; Wallaceville Animal Research Centre, Upper Hutt, NZ; Malaghan Medical Research Institute, Wellington.

  • Past Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2017 - 2021 Co-Supervisor Understanding the development of gut microbiota and effect of Salmonella Typhimurium infection on gut microbiota in layers Doctor of Philosophy Doctorate Full Time Dr Nitish Narendra Joat

  • Board Memberships
    Date Role Board name Institution name Country
    2015 - ongoing Chair Board of Directors Roseworthy Piggery Pty Ltd Australia
    2015 - ongoing Member Board of AW Howard Memorial Trust Inc AW Howard Memorial Trust Inc -
    2015 - ongoing Member Academic Board University of Adelaide -
    2013 - ongoing Advisory Board Member Interdisciplinary Program for Biomedical Sciences Institute for Academic initiatives, Osaka University Japan

  • Committee Memberships
    Date Role Committee Institution Country
    2014 - ongoing Chair External Review Panel - conducting review of clinical training and operation of the teaching hospital College of Veterinary Medicine, Murdoch University Australia
    2014 - ongoing Member Animal Biosecurity RDE Steering Group Animal Health Australia -
    2012 - ongoing Chair External Review Panel (conducting review of preclinical training) Murdoch University Australia
    2012 - ongoing Member Biology and Biotechnology Research Evaluation Committee Excellence of Research in Australia (ERA), Australian Research Council Australia
    2010 - ongoing Member Peer Review Panel of the Danish Council for Strategic Research - -
    2010 - 2011 Member Marsden Fund Ecology Evolution and Behaviour Review Panel Royal Society of New Zealand New Zealand
    2007 - 2013 Chair Veterinary Immunology Committee Sub-committee of the International Union of Immunological Societies -
    2005 - 2007 Member Marsden Fund Biomedical Sciences Review Panel Royal Society of New Zealand New Zealand
    2003 - 2007 Member Scientific Advisory Committee of the Australian Wool Innovation / Meat and Livestock Australia research programme on Functional Genomics of the Host Response to Intestinal Parasites Meat and Livestock Australia -
    2003 - 2006 Member Technical Advisory Group Animal Health Board of New Zealand New Zealand
    2002 - 2009 Co-Chair Veterinary Immunology SIG Australasian Society for Immunology -
    1997 - ongoing Member Invited Member of BBSRC Committee Babraham Institute United Kingdom
    1996 - ongoing Member Invited Member of BBSRC Committee Institute for Animal Health United Kingdom

  • Consulting/Advisories
    Date Institution Department Organisation Type Country
    1995 - ongoing Moredun Research Institute - - United Kingdom

  • Editorial Boards
    Date Role Editorial Board Name Institution Country
    2015 - ongoing Editor The Veterinary Journal - -
    2014 - 2016 Editor Encyclopaedia of Immunobiology Elsevier -
    2004 - 2012 Editor International Journal for Parasitology - -
    2000 - 2011 Member Developmental and Comparative Immunology - -
    1999 - 2008 Editor Veterinary Immunology and Immunopathology - -
    1992 - ongoing Member The Veterinary Journal - -
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