Bioinformatics Data Scientist
School of Animal and Veterinary Science
Faculty of Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
I am currently a Bioinformatics Data Scientist at Davies Research Centre, University of Adelaide. Prior to this I was an Assistant Professor and Head of Products and Services at the Perdana University Centre for Bioinformatics (PU-CBi), which is under the School of Data Sciences. I obtained my Ph.D in Genetics from the University of Melbourne and did my postdoctoral fellowships at the Monash University. Currently, I am also taking a part-time graduate diploma in Biostatistics, which is a course delivered by the Biostatistics Collaboration of Australia (BCA).
My research interests are in the areas of next generation sequencing (NGS) technology, genome assembly, gene annotation, molecular evolution, and comparative genomics. The species I have worked on include fly, worm, human, primate, bacteria, water buffalo and cattle. I have authored/co-authored research articles at internationally recognized, peer-reviewed journals and I have presented my work at numerous international conferences. I am a co-author of two patents related to the important discovery and genomic analyses of a probiotic bacteria. Recently I have also written a practical handbook on NGS.
I also have experience in creating e-Learning educational contents in Biology, teaching bioinformatics, biostatistics and genetics to undergraduate/postgraduate students. Additionally, I was an invited speaker for two NGS workshops and I was also the main facilitator for a workshop on using R in biostatistics.
- My Research
- Grants and Funding
- Professional Activities
I am currently a Bioinformatics Data Scientist at Davies Research Centre, University of Adelaide. My research interests are in the areas of next generation sequencing (NGS) technology, genome assembly, gene annotation, molecular evolution, comparative genomics, genetic disorders and metagenomics. The species I have worked on include fly, worm, human, primate, bacteria, water buffalo and cattle. I have authored/co-authored research articles at internationally recognized, peer-reviewed journals and I have presented my work at numerous international conferences. I am a co-author of two patents related to the important discovery and genomic analyses of a probiotic bacteria. Recently I have also written a practical handbook on NGS and regularly contributing to a bioinformatics website (https://bioinformaticshome.com).
Date Position Institution name 2017 Bioinformatics data scientist University of Adelaide 2014 - 2017 Assistant Professor Perdana University
Language Competency Chinese (Cantonese) Can speak and understand spoken English Can read, write, speak, understand spoken and peer review Malay Can read, write, speak, understand spoken and peer review
Date Institution name Country Title 2009 - 2009 University of Melbourne Australia PhD (Genetics)
Year Citation 2020 Rosen, B. D., Bickhart, D. M., Schnabel, R. D., Koren, S., Elsik, C. G., Tseng, E., . . . Medrano, J. F. (2020). De novo assembly of the cattle reference genome with single-molecule sequencing.. GigaScience, 9(3).
2020 Chong, C., Alkatheeri, A., Ali, N., Tay, Z., Lee, Y., Paramasivam, S., . . . Lim, S. (2020). Association of antimicrobial resistance and gut microbiota composition in human and non-human primates at an urban ecotourism site. Gut Pathogens, 12(1), 14.
2019 Liu, R., Low, W. Y., Tearle, R., Koren, S., Ghurye, J., Rhie, A., . . . Williams, J. L. (2019). New insights into mammalian sex chromosome structure and evolution using high-quality sequences from bovine X and Y chromosomes.. BMC Genomics, 20(1), 1000.
2019 Low, W., Tearle, R., Bickhart, D., Rosen, B., Kingan, S., Swale, T., . . . Williams, J. (2019). Chromosome-level assembly of the water buffalo genome surpasses human and goat genomes in sequence contiguity. Nature Communications, 10(1), 11 pages.
DOI Scopus7 WoS10 Europe PMC3
2019 Liu, S., Kang, X., Catacchio, C., Liu, M., Fang, L., Schroeder, S., . . . Liu, G. (2019). Computational detection and experimental validation of segmental duplications and associated copy number variations in water buffalo (Bubalus bubalis). Functional and Integrative Genomics, 19(3), 409-419.
DOI Scopus3 WoS3
2019 Liu, Y., Ong, J., Gan, C., Khoo, B., Yahaya, S., Choi, S., . . . Liong, M. (2019). Lactobacillus fermentum PS150 showed psychotropic properties by altering serotonergic pathway during stress. Journal of Functional Foods, 59, 352-361.
DOI Scopus1 WoS1
2018 Tan, H., & Low, W. (2018). Rapid birth-death evolution and positive selection in detoxification-type glutathione S-transferases in mammals. PLoS ONE, 13(12), 1-15.
DOI Scopus1 WoS1 Europe PMC1
2017 Kanagarajah, R. R., Lee, D. C. W., Lee, D. Z. F., Yusoff, K., Paramasivam, S. J., Low, W. Y., . . . Lim, S. H. E. (2017). Antibiotic profiling of Methicillin Resistant Staphylococcus aureus (MRSA) isolates in stray canines and felines. Cogent Biology, 3(1).
2017 Davis, G., Low, W., Anderson, J., & Boag, P. (2017). Exploring potential germline associated roles of the TRIM-NHL protein NHL-2 through RNAi screening. G3 : Genes, Genomes, Genetics, 7(10), 3251-3256.
DOI Scopus2 WoS2 Europe PMC1
2017 Williams, J., Iamartino, D., Pruitt, K., Sonstegard, T., Smith, T., Low, W., . . . Zimin, A. (2017). Genome assembly and transcriptome resource for river buffalo, Bubalus bubalis (2n = 50). GigaScience, 6(10), 1-6.
DOI Scopus12 WoS13 Europe PMC5
2017 Lye, H., Kato, T., Low, W., Taylor, T., Prakash, T., Lew, L., . . . Liong, M. (2017). Lactobacillus fermentum FTDC 8312 combats hypercholesterolemia via alteration of gut microbiota. Journal of Biotechnology, 262, 75-83.
DOI Scopus13 WoS10 Europe PMC4
2013 Sengupta, M., Low, W., Patterson, J., Kim, H. -M., Traven, A., Beilharz, T., . . . Boag, P. (2013). ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans. Journal of Cell Science, 126(3), 850-859.
DOI WoS18 Europe PMC14
2010 Low, W., Feil, S., Ng, H., Gorman, M., Morton, C., Pyke, J., . . . Batterham, P. (2010). Recognition and detoxification of the insecticide DDT by Drosophila melanogaster glutathione S-transferase D1. Journal of Molecular Biology, 399(3), 358-366.
DOI Scopus40 WoS36 Europe PMC23
2007 Low, W., Ng, H., Morton, C., Parker, M., Batterham, P., & Robin, C. (2007). Molecular evolution of glutathione S-transferases in the genus Drosophila. Genetics, 177(3), 1363-1375.
DOI WoS69 Europe PMC60
2007 Clark, A., Eisen, M., Smith, D., Bergman, C., Oliver, B., Markow, T., . . . Han, M. (2007). Evolution of genes and genomes on the Drosophila phylogeny. Nature, 450(7167), 203-218.
DOI Scopus1288 WoS1313 Europe PMC1151
2005 Low, W. Y. (2005). Homocysteine, Folic Acid and Vitamin C in Young Malaysian Smokers and Non Smokers. Malaysian Journal of Biochemistry and Molecular Biology.
Year Citation 2019 Ong, C., Kwong, Q., Ong, A., Heng, H., & Low, W. (2019). Pipeline of High Throughput Sequencing. In S. Ranganathan, M. Gribskov, K. Nakai, & C. Schönbach (Eds.), Encyclopedia of Bioinformatics and Computational Biology (Vol. 3, pp. 144-151).
2017 Low, W., & Tammi, M. (2017). Introduction to next generation sequencing technologies. In W. Low, & M. Tammi (Eds.), Bioinformatics: A practical handbook of next generation sequencing and Its applications (pp. 1-21). World Scientific Publishing.
Year Citation 2018 Ali, N., Chong, C. W., Low, W. Y., Alkatheeri, A. H. S., Mustaqqim, F., Tay, Z. H., . . . Lim, S. H. E. (2018). Poorly-managed ecotourism: Risk factor for transmission of MDR bacteria from non-human primates?. In Archive Clinical Microbiology 2018. Madrid, Spain.
2017 Low, W. (2017). Population entropies estimates of proteins. In Proceedings of the 3rd ISM International Statistical Conference 2016: Bringing Professionalism and Prestige in Statistics, as published in AIP Conference Proceedings Vol. 1842 (pp. 1-7). Kuala Lumpur, Malaysia: American Institute of Physics.
Year Citation 2017 Low, W. Y. (2017). WO 2018/129722 A1, A novel lactic acid bacteria and its applications. Taiwan.
Year Citation 2009 Low, W. Y. (2009). Molecular evolution, structure and function of Glutathione S-Transferases in the genus Drosophila. (PhD Thesis, The University of Melbourne).
A case control study to discover systemic gut microbiome changes in spinal muscular atrophy. (2016 - ongoing) Funded by the Malaysian Medical Association Foundation. Role: Principal Investigator
Post-transcriptional gene regulation in RNA-granules (2010 – 2013) Funded by National Health and Medical Research Council. Role: Postdoctoral Research Fellow.
Using comparative genomics to identify genes responsible for adaptation to environmental toxins (Discovery Projects) (2005 – 2008) Funded by Australia Research Council. Role: PhD student.
Taught Biostatistics, Genetics and Molecular Evolution to post-graduate students at Perdana University (Sep 2014 – Jan 2017).
Senior Lecturer and Head of Biotechnology undergraduate program at the Manipal International University (Aug 2013 – Sep 2014). Taught Computational Biology and Genetics to undergraduate students and prepared documents in compliance with Malaysian Qualifications Agency (MQA).
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2020 Principal Supervisor Deciphering 3D Genome Structure of Cattle using Machine Learning: Implications for Climate Change Doctor of Philosophy Doctorate Full Time Mr Callum Macphillamy 2019 Co-Supervisor Investigation of the effect of using antimicrobials on resistance of Escherichia coli, Enterococcus, and Salmonella species in faeces and carcase in beef feedlot Doctor of Philosophy Doctorate Full Time Dr Yohannes Equar Messele 2019 Co-Supervisor Molecular Pathogenesis of Newly Emerged Newcastle Disease Virus in Indonesia Doctor of Philosophy Doctorate Full Time Mr Mohammad Rabiei
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