Dr Tracy Fitzsimmons

Tracy Fitzsimmons
NHMRC Postdoctoral Researcher
Adelaide Dental School
Faculty of Health and Medical Sciences

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Dr Tracy Fitzsimmons

My studies focus on the host cell immune and inflammatory response to microbial infection associated with periodontal disease, specifically Porphyromonas gingivalis.  In addition, a key area of interest is exploring the relationship between periodontitis and systemic diseases such as rheumatoid arthritis in terms of adjunct therapy to standard treatment regimes.  I have extensive experience relating to detection and quantification of inflammatory mediators locally in the oral cavity, gums and tissues, particularly gingival crevicular fluid (GCF) utilising multiplex and ELISA's in addition to a number of molecular biology techniques and cell culture.

Appointments

Date Position Institution name
2005 Post-doctoral Researcher University of Adelaide
2005 - 2005 Research Officer Numico Research Australia
1998 - 2004 Research Assistant Royal Adelaide Hospital, Adelaide

Awards and Achievements

Date Type Title Institution Name Amount
2017 - 2017 Piksters Periodontal Award Australian Dental Research Foundation Inc

Education

Date Institution name Country Title
2000 - 2005 University of Adelaide Australia PhD
1997 - 1997 University of Adelaide Australia Honours
1994 - 1996 University of Adelaide Australia Bachelor of Health Sciences

Keywords

Arthritis & Rheumatology, Cellular Immunology, Dentistry, Innate Immunity, Oral Medicine and Pathology, Periodontics

Journals

Date Citation
2016 Chee,B, Park,B, Fitzsimmons,T, Coates,A, Bartold,P, 2016, Omega-3 fatty acids as an adjunct for periodontal therapy-a review, Clinical Oral Investigations, 20, 5, 879-894 10.1007/s00784-016-1750-2
2015 Doyle,C, Fitzsimmons,T, Marchant,C, Dharmapatni,A, Hirsch,R, Bartold,P, 2015, Azithromycin suppresses P. gingivalis LPS-induced pro-inflammatory cytokine and chemokine production by human gingival fibroblasts in vitro, Clinical Oral Investigations, 19, 2, 221-227 10.1007/s00784-014-1249-7
2015 Stockham,S, Stamford,J, Roberts,C, Fitzsimmons,T, Marchant,C, Bartold,P, Zilm,P, 2015, Abnormal pregnancy outcomes in mice using an induced periodontitis model and the haematogenous migration of Fusobacterium nucleatum sub-species to the murine placenta, PLoS One, 10, 3, e0120050-1-e0120050-16 10.1371/journal.pone.0120050
2013 Harvey,G, Fitzsimmons,T, Dharmapatni,A, Marchant,C, Haynes,D, Bartold,P, 2013, Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva, Journal of Periodontal Research, 48, 2, 252-261 10.1111/jre.12002
2010 Megson,E, Fitzsimmons,T, Dharmapatni,A, Bartold,P, 2010, C-reactive protein in gingival crevicular fluid may be indicative of systemic inflammation, Journal of Clinical Periodontology, 37, 9, 797-804 10.1111/j.1600-051X.2010.01603.x
2010 Fitzsimmons,T, Sanders,A, Bartold,P, Slade,G, 2010, Local and systemic biomarkers in gingival crevicular fluid increase odds of periodontitis, Journal of Clinical Periodontology, 37, 1, 30-36 10.1111/j.1600-051X.2009.01506.x
2009 Fitzsimmons,T, Sanders,A, Slade,G, Bartold,P, 2009, Biomarkers of periodontal inflammation in the Australian adult population, Australian Dental Journal, 54, 2, 115-122 10.1111/j.1834-7819.2009.01103.x
2009 Tang,T, Fitzsimmons,T, Bartold,P, 2009, Effect of smoking on concentrations of receptor activator of nuclear factor κ B ligand and osteoprotegerin in human gingival crevicular fluid, Journal of Clinical Periodontology, 36, 9, 713-718 10.1111/j.1600-051X.2009.01444.x
2009 Sanders,A, Slade,G, Fitzsimmons,T, Bartold,P, 2009, Physical activity, inflammatory biomarkers in gingival crevicular fluid and periodontitis, Journal of Clinical Periodontology, 36, 5, 388-395 10.1111/j.1600-051X.2009.01394.x

Conference Papers

Date Citation
2007 McNamara,TR, Slade,GD, Sanders,AE, Do,LG, Bartold,PM, 2007, Contributions of local and systemic inflammation to periodontitis among Australians, IADR, New Orleans
2007 Fitzsimmons,TR, 2007, Contributions of local and systemic inflammation to periodontitis among Australians, IADR, New Orleans
2007 Sanders,AE, Slade,GD, Bartold,PM, McNamara,TR, Do,LG, 2007, Effect modification of smoking and poverty on periodontal inflammatory response, IADR, New Orleans

 

Date Project Title Investigators Funding Body Amount
2017 Azithromycin modulation of cytokine production during LPS induced/chronic inflammation in vitro:  Impact on osteoclastogenesis TR Fitzsimmons, D Haynes, PM Bartold Australian Dental Research Foundation $11,050
2014 Cytokine profiles in serum and placenta of pregnant mice following experimentally induced periodontitis P Zilm, TR Fitzsimmons, C Roberts.  Australian Dental Research Foundation $13,764
2014 Fish oil as an adjunct therapy for periodontitis – a pilot study to determine whether there are acute and chronic benefits? A Coates, TR Fitzsimmons, PM Bartold, S Ivanovski, P Howe Australian Dental Research Foundation $9000
2012 Effect of Azithromycin on cytokine expression by human gingival fibroblasts C Doyle, Bartold PM, TR Fitzsimmons, C Marchant Australian Dental Research Foundation $6000
2010 Multiplex analysis of the presence of IL-13, IL-15 and IL-17 in gingival crevicular fluid of subjects with periodontitis TR Fitzsimmons Australian Dental Research Foundation $5600
2009 A NanoDrop spectrophotometer system for micro-volume quantitation of nucleic acid and protein TR Fitzsimmons, PS Zilm, PM Bartold, P Cathro, D Haynes, S Gronthos, T Hughes, G Townsend, D Keefe National Health and Medical Research Council, Equipment Grant $10,000
2009 Identification and quantitation of periodontal pathogens by real-time polymerase chain reaction TR McNamara, N Gully, PS Zilm Australian Dental Research Foundation $4000
2009 The effects of environmental redox potential (Eh) and pH on Fusobacterium nucleatum and Porphyromonas gingivalis co-cultured biofilms J Chew, N Gully, PS Zilm, TR McNamara Australian Dental Research Foundation $4000
2009 An in-vitro evaluation of the effectiveness of endodontic irrigants, with and without ultrasonic activation, in the eradication of Enterococcus faecalis biofilm A Seet, P Cathro, PS Zilm, TR McNamara, N Gully Australian Dental Research Foundation $4000
2009 Efficacy of antimicrobial treatment involving sodium hypochlorite, ledermix and calcium hydroxide against Enterococcus faecalis cultured as a biofilm on a dentine substrate PS Zilm, P Cathro, B Plutzer, TR McNamara Australian Dental Research Foundation $4000
2008 Influence of smoking on molecules associated with bone resorption in human gingival crevicular fluid.  Australian Dental Research Foundation PM Bartold, TR McNamara, T Tang Australian Dental Research Foundation $6600
2007 Investigation of proteins in gingival crevicular fluid as a basis for disease diagnosis T McNamara, P Zilm, C Bagley, PM Bartold Australian Dental Research Foundation $4800

 

Dates Teaching Role Course School, Faculty, Institution Subject Code
Semester 1, 2009 Casual Tutor Human Biology ID Part 1 School of Dentistry, Faculty of Health Sciences, University of Adelaide 2910_DENT_1003AHO
Semester 2, 2008 Casual Tutor Dental and Health Science II Part 2 School of Dentistry, Faculty of Health Sciences, University of Adelaide 2620_DENT_2001BHO
Semester 2, 2006 Casual Ttor Dental and Health Science II Part 2 School of Dentistry, Faculty of Health Sciences, University of Adelaide 2620_DENT_2001BHO

 

Doctor of Clinical Dentistry

Year Role Project Title Institution Student
2011-2013 Research Supervisor Azithromycin suppresses P. gingivalis LPS induced proinflammatory cytokine and chemokine production (IL-6, IL-8, MCP-1 and GRO) by human gingival fibroblasts in vitro University of Adelaide Dr Catherine Doyle
2009-2011 Research Supervisor

Expression of rheumatoid arthritis markers in normal and inflamed gingival tissues

http://hdl.handle.net/2440/73851

University of Adelaide Dr Geoffrey Harvey
2009-2011 Research Supervisor

Expression of bone resorption markers in gingival crevicular fluid of rheumatoid arthritis patients with and without periodontitis: a pilot study

http://hdl.handle.net/2440/77344

University of Adelaide Dr Kere Kobayashi
2008-2010 Research Supervisor

C-reactive protein, periodontitis and systemic inflammation

http://hdl.handle.net/2440/65876

University of Adelaide Dr Emma Megson
2007-2009 Research Supervisor

Effect of smoking on concentrations of RANKL and OPG in human gingival crevicular fluid

http://hdl.handle.net/2440/52595

University of Adelaide Dr Teck Tang
Honours
Year Role Project Title Institution Student
2017 Primary Supervisor Azithromycin modulation of cytokine production during LPS induced/chronic inflammation in vitro:  Impact on osteoclastogenesis University of Adelaide Dr Alen Rahulan

Memberships

Date Role Membership Country
2016 Member International Association for Dental Research, Australian/New Zealand Division Australia
2016 Member International Association for Dental Research United States

Committee Memberships

Date Role Committee Institution Country
2016 Member Local Organising Committee IADR ANZ Australia
Position
NHMRC Postdoctoral Researcher
Phone
83135677
Fax
8313 6429
Campus
North Terrace
Building
Medical School South
Room Number
3 21
Org Unit
Colgate

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