
Miss Tira Rattanakosit
Higher Degree by Research Candidate
PhD Candidate
Adelaide Medical School
Faculty of Health and Medical Sciences
A Medical scientist with a business mind
by day: PhD Candidate in Centre of Heart Rhythm Disorder
♀️ by night: Director of The Sorcerer's Bar
Project: PhD CandidateAtrial fibrillation (AF) is the most common type of arrhythmia seen in clinical practice. This asymptomatic disease affects approximately 1%–2% of the population and is one of the most common underlying cause of stroke. The underlying pathological initiation of AF is still under research. The abnormal electrical signal generally comes from the Pulmonary Vein. However, other tissue areas such as the coronary sinus musculature and superior vena cava have been recently identified as one of the initiation sites. The pathophysiology of AF demonstrates a complex relationship between the triggers, substrate and autonomic influences, thus the adverse cardiac physiological alterations may limit the possibility to restore and maintain the normal sinus rhythm.
Although options like antiarrhythmic drugs are widely used to combat the disorganized beats, due to poor efficacy of pharmacological therapy, patients are often recommended to undergo catheter ablations. An energy source such as Cryoablation (cold energy) and Radiofrequency ablation (hot energy) are used to ablate the dysfunction tissue. With recent studies showing Radiofrequency ablation (RF) to have high successful rates and less fluoroscopy exposure time, compared to Cryoablation, RF ablation catheter is now predominately used. The ablation for atrial fibrillation requires extensive ablation that involves the risk of collateral damage to the oesophagus, pulmonary veins, lungs, and the circumflex coronary artery. At the same time, there is recurrence due to gaps in linear ablation lines due to the recovery or repair of the tissue by the body.
This indicates that the key factors such as force, time and power, plays a predominant role in forming durable transmural lesions. Recently, novel indices have combined these key factors in a weighted formula known as Ablation Index and Lesion-Size Index to assist in lesion delivery. Further studies on these areas will provide better knowledge of lesion creation and its durability.
A Medical scientist with a business mind ??
????by day: PhD Candidate in Centre of Heart Rhythm Disorder
??♀️?by night: Director of The Sorcerer's Bar
Project: PhD CandidateAtrial fibrillation (AF) is the most common type of arrhythmia seen in clinical practice. This asymptomatic disease affects approximately 1%–2% of the population and is one of the most common underlying cause of stroke. The underlying pathological initiation of AF is still under research. The abnormal electrical signal generally comes from the Pulmonary Vein. However, other tissue areas such as the coronary sinus musculature and superior vena cava have been recently identified as one of the initiation sites. The pathophysiology of AF demonstrates a complex relationship between the triggers, substrate and autonomic influences, thus the adverse cardiac physiological alterations may limit the possibility to restore and maintain the normal sinus rhythm.
Although options like antiarrhythmic drugs are widely used to combat the disorganized beats, due to poor efficacy of pharmacological therapy, patients are often recommended to undergo catheter ablations. An energy source such as Cryoablation (cold energy) and Radiofrequency ablation (hot energy) are used to ablate the dysfunction tissue. With recent studies showing Radiofrequency ablation (RF) to have high successful rates and less fluoroscopy exposure time, compared to Cryoablation, RF ablation catheter is now predominately used. The ablation for atrial fibrillation requires extensive ablation that involves the risk of collateral damage to the oesophagus, pulmonary veins, lungs, and the circumflex coronary artery. At the same time, there is recurrence due to gaps in linear ablation lines due to the recovery or repair of the tissue by the body.
This indicates that the key factors such as force, time and power, plays a predominant role in forming durable transmural lesions. Recently, novel indices have combined these key factors in a weighted formula known as Ablation Index and Lesion-Size Index to assist in lesion delivery. Further studies on these areas will provide better knowledge of lesion creation and its durability.
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Education
Date Institution name Country Title 2017 South Australian Health and Medical Research Institute, Adelaide Australia Doctor of Philosophy in Cardiac Arrythmia 2016 - 2016 University of Adelaide Australia Bachelor of Health Sciences (Honours) 2012 - 2015 University of Adelaide, Adelaide Australia Bachelor of Health Sciences -
Research Interests
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Journals
Year Citation 2021 Franke, K. B., Marshall, H., Kennewell, P., Pham, H. D., Tully, P. J., Rattanakosit, T., . . . Mahajan, R. (2021). Risk and predictors of sudden death in cardiac sarcoidosis: A systematic review and meta-analysis. International Journal of Cardiology, 328, 130-140.
Scopus4 WoS4 Europe PMC22021 Rattanakosit, T., Franke, K., Munawar, D. A., Page, A. J., Boyd, M. A., Lau, D. H., & Mahajan, R. (2021). Role of Indices Incorporating Power, Force and Time in AF Ablation: A Systematic Review of Literature. Heart, Lung and Circulation, 30(9), 10 pages.
Scopus3 WoS1 Europe PMC1 -
Conference Items
Year Citation 2019 Agbaedeng, T. A., Emami, M., Munawar, D. A., Rattanakosit, T., Khadim, K. I., Elliott, A., . . . Sanders, P. (2019). Fibrosis detected by late-gadolinium enhancement cardiac MRI is associated with atrial fibrillation and poorer ablation outcome: A meta-analysis. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Paris, FRANCE: OXFORD UNIV PRESS. 2019 Franke, K., Marshall, H., Kennewell, P., Pham, H., Rattanakosit, T., Aboustate, N., . . . Mahajan, R. (2019). Incidence of appropriate implantable cardioverter defibrillator therapy and sudden cardiac death in cardiac sarcoidosis - a systematic review and meta-analysis. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Paris, FRANCE: OXFORD UNIV PRESS.
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