Dr Thomas Fallon
Lecturer
School of Physics, Chemistry and Earth Sciences
Faculty of Sciences, Engineering and Technology
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
The Fallon group works on the chemistry of shape-shifting molecules. These intriguing dynamic systems have no permanent structure and exist in constant metamorphosis. We develop new synthetic and analytical methods, and are applying these systems in molecular devices and medicinal chemistry.
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Journals
Year Citation 2023 Ottonello, A., Wyllie, J. A., Yahiaoui, O., Sun, S., Koelln, R. A., Homer, J. A., . . . Moses, J. E. (2023). Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria. Proceedings of the National Academy of Sciences of the United States of America, 120(15), e2208737120.
2022 Birve, A., Patel, H. D., Price, J. R., Bloch, W. M., & Fallon, T. (2022). Guest-dependent isomer convergence of a permanently fluxional coordination cage. Angewandte Chemie International Edition, 61(9), e202115468-1-e202115468-6.
Scopus13 WoS13 Europe PMC42022 Patel, H. D., Gaggl, S., Pašteka, L. F., & Fallon, T. (2022). Ambimodal Pericyclic Rearrangements of Dialkenyl-Bullvalenes Give Tetrahydro-1,8-ethenoheptalenes. Organic Letters, 24(1), 319-323.
Scopus1 WoS12022 Patel, H. D., & Fallon, T. (2022). Two Steps to Bicyclo[4.2.0]octadienes from Cyclooctatetraene: Total Synthesis of Kingianic Acid A. Organic Letters, 24(12), 2276-2281.
Scopus2 WoS2 Europe PMC12022 Zur Bonsen, A. B., Peralta, R. A., Fallon, T., Huang, D. M., & George, J. H. (2022). Intramolecular Tricarbonyl-Ene Reactions and α-Hydroxy-β-Diketone Rearrangements Inspired by the Biosynthesis of Polycyclic Polyprenylated Acylphloroglucinols. Angewandte Chemie International Edition, 61(34), e202203311-1-e202203311-11.
Europe PMC12021 Yahiaoui, O., Patel, H. D., Chinner, K. S., Pašteka, L. F., & Fallon, T. (2021). Stereomutation of Substituted Bullvalenes.. Organic letters, 23(4), 1157-1162.
Scopus4 WoS5 Europe PMC22021 Shadfar, Z., Yahiaoui, O., Collier, T. A., Fallon, T., & Allison, J. R. (2021). Illustration of a computational pipeline for evaluating cyclodextrin host-guest complex formation through conformational capture of bullvalene.. The Journal of chemical physics, 154(15), 1-15.
Scopus2 WoS22020 Lording, W. J., Fallon, T., Sherburn, M. S., & Paddon-Row, M. N. (2020). The simplest Diels-Alder reactions are not: Endo -selective. Chemical Science, 11(43), 11915-11926.
Scopus19 WoS16 Europe PMC12020 Patel, H. D., Tran, T. -H., Sumby, C. J., Pašteka, L. F., & Fallon, T. (2020). Boronate Ester Bullvalenes. Journal of the American Chemical Society, 142(8), 3680-3685.
Scopus11 WoS10 Europe PMC32020 Guo, Y., Empel, C., Pei, C., Atodiresei, I., Fallon, T., & Koenigs, R. M. (2020). Photochemical Cyclopropanation of Cyclooctatetraene and (Poly-)unsaturated Carbocycles.. Organic letters, 22(13), 5126-5130.
Scopus20 WoS19 Europe PMC12020 Peralta, R. A., Huxley, M. T., Evans, J. D., Fallon, T., Cao, H., He, M., . . . Doonan, C. J. (2020). Highly active gas phase organometallic catalysis supported within metal-organic framework pores. Journal of the American Chemical Society, 142(31), 13533-13543.
Scopus26 WoS26 Europe PMC52020 Vieira de Castro, T., Yahiaoui, O., Peralta, R. A., Fallon, T., Lee, V., & George, J. H. (2020). Biomimetic synthesis enables the structure revision of littordials E and F and drychampone B. Organic Letters, 22(20), 8161-8166.
Scopus12 WoS12 Europe PMC22020 Yahiaoui, O., Almass, A., & Fallon, T. (2020). Total synthesis of endiandric acid J and beilcyclone A from cyclooctatetraene. CHEMICAL SCIENCE, 11(35), 9421-9425.
Scopus7 WoS7 Europe PMC22019 Murray, L. A. M., Fallon, T., Sumby, C. J., & George, J. H. (2019). Total synthesis of naphterpin and marinone natural products. Organic Letters, 21(20), 8312-8315.
Scopus18 WoS16 Europe PMC32019 Yahiaoui, O., Pašteka, L. F., Blake, C. J., Newton, C. G., & Fallon, T. (2019). Network Analysis of Substituted Bullvalenes.. Org Lett, 21(23), 9574-9578.
Scopus10 WoS10 Europe PMC42018 Yahiaoui, O., Pašteka, L., Judeel, B., & Fallon, T. (2018). Synthesis and Analysis of Substituted Bullvalenes. Angewandte Chemie - International Edition, 57(10), 2570-2574.
Scopus23 WoS20 Europe PMC92017 Fallon, T., & Meek, T. (2017). Simplified "no-D" NMR Methods for Routine Analysis and Organometallic Reagent Concentration Determination. Organic Letters, 19(21), 5752-5755.
Scopus1 WoS12016 Saglam, M. F., Fallon, T., Paddon-Row, M. N., & Sherburn, M. S. (2016). Discovery and computational rationalization of diminishing alternation in [n]dendralenes. Journal of the American Chemical Society, 138(3), 1022-1032.
Scopus18 WoS18 Europe PMC42015 Fallon, T., & Oestreich, M. (2015). A Constellation of Deuterium-Labeled Silanes as a Simple Mechanistic Probe not Requiring Absolute Configuration Determination. Angewandte Chemie - International Edition, 54(42), 12488-12491.
Scopus21 WoS20 Europe PMC102015 Pareek, M., Fallon, T., & Oestreich, M. (2015). Platinum(0)-Catalyzed Indolyne Insertion into Bis(pinacolato)diboron Followed by Site-Selective Suzuki-Miyaura Cross-Coupling. Organic Letters, 17(9), 2082-2085.
Scopus22 WoS17 Europe PMC42015 Mackay, E., Newton, C., Toombs-Ruane, H., Lindeboom, E., Fallon, T., Willis, A., . . . Sherburn, M. (2015). [5]Radialene. Journal of the American Chemical Society, 137(46), 14653-14659.
Scopus23 WoS22 Europe PMC32014 Fallon, T., Willis, A. C., Paddon-Row, M. N., & Sherburn, M. S. (2014). Furanodendralenes. The Journal of Organic Chemistry, 79(7), 3185-3193.
Scopus13 WoS13 Europe PMC32014 Redies, K. M., Fallon, T., & Oestreich, M. (2014). En route to stable all-carbon-substituted silylenes: Synthesis and reactivity of a bis(α-spirocyclopropyl)silylene. Organometallics, 33(13), 3235-3238.
Scopus9 WoS82012 Fallon, T., Willis, A. C., Rae, A. D., Paddon-Row, M. N., & Sherburn, M. S. (2012). β-Oligofurans. Chemical Science, 3(6), 2133-2137.
Scopus22 WoS232011 Toombs-Ruane, H., Osinski, N., Fallon, T., Wills, C., Willis, A. C., Paddon-Row, M. N., & Sherburn, M. S. (2011). Synthesis and applications of tricarbonyliron complexes of dendralenes. Chemistry - An Asian Journal, 6(12), 3243-3250.
Scopus15 WoS13 Europe PMC32010 Fallon, T., Robinson, D. E. J. E., Willis, A. C., Paddon-Row, M. N., & Sherburn, M. S. (2010). Double dehydro-diels-alder reactions of 1,5-dien-3-ynes. Chemistry - A European Journal, 16(3), 760-765.
Scopus8 WoS7 Europe PMC2- Patel, H., Tran, T. H., Sumby, C., Pašteka, L., & Fallon, T. (n.d.). Boronate Ester Bullvalenes.
- Ottonello, A., Wyllie, J. A., Yahiaoui, O., Murray, E., Williams, P., Bolla, J. R., . . . Moses, J. E. (n.d.). Shapeshifting Antibiotics: Bullvalene Linked Vancomycin Dimers are Effective Against Multidrug-Resistant Gram-Positive Bacteria.
New Zealand Royal Society Marsden Fast-Start grant 2016-2019.
- Chemical Kinetics (1st year)
- Purification and Analytical Chemistry (2nd year)
- Aromatic chemistry (2nd year)
- Bioorganic chemistry (2nd year)
- Stereoselective synthesis (3rd year)
- Pericyclic Chemistry (Honours)
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2021 Co-Supervisor Biomimetic Total Synthesis of Natural Products Doctor of Philosophy Doctorate Full Time Miss Emma Caitlin Becroft 2020 Co-Supervisor Use of Peroxygenase P450 Enzymes as Oxidative Catalysts in the Synthesis of Natural Products Doctor of Philosophy Doctorate Full Time Ms Jinia Akter 2019 Co-Supervisor Biomimetic synthesis of complex natural products Doctor of Philosophy Doctorate Full Time Miss Sarah Alexandra French -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 - 2022 Co-Supervisor Biomimetic Synthesis Enables the Structural Revision of Natural Products Master of Philosophy Master Full Time Mr Tomas Mendes Gouveia Vieira deCastro 2020 - 2023 Principal Supervisor Diels-Alder and Electrocyclic Strategies in Complex Molecule Synthesis Doctor of Philosophy Doctorate Full Time Mr Isuru Dissanayake Mudiyanselage 2018 - 2022 Principal Supervisor Synthesis and Applications of Substituted Bullvalenes and The Synthesis of Bicyclo[4.2.0]octadiene Derived Natural Products Doctor of Philosophy Doctorate Full Time Mr Harshal Deepak Patel 2018 - 2020 Co-Supervisor Synthesis and Network Analysis of Substituted Bullvalenes and the Total Synthesis of Endiandric Acid J and Beilcyclone A Doctor of Philosophy Doctorate Full Time Mr Ossama Yahiaoui 2018 - 2023 Co-Supervisor Small Molecules Targeting Novel Mycobacterium tuberculosis Drug Targets Doctor of Philosophy Doctorate Full Time Mr Nicholas Charles Schumann
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