Thomas Altree

• Appointments

  Date	Position	Institution name
  2024 - ongoing	Senior Clinical Lecturer	University of Adelaide
  2024 - ongoing	Senior Research Fellow	Flinders University
  2022 - ongoing	Respiratory and Sleep Physician	SA Health

• Awards and Achievements

  Date	Type	Title	Institution Name	Country	Amount
  2023	Research Award	New Investigator Award	World Sleep Society	United States	-

• Education

  Date	Institution name	Country	Title
  2024	Flinders University	Australia	PhD
  2012	University of Adelaide	Australia	MBBS

• Certifications

  Date	Title	Institution name	Country
  2019	FRACP	Royal Australasian College of Physicians	Australia

• Journals

  Year	Citation
  2024	Altree, T. J., Pinczel, A., Toson, B., Loffler, K., Hudson, A., Zeng, J., . . . Eckert, D. (2024). The effects of low-dose morphine on sleep and breathlessness in COPD: A randomized trial. Chest, 1-13. DOI
  2024	Altree, T. J., & Barateau, L. (2024). The borderland down under. JOURNAL OF CLINICAL SLEEP MEDICINE, 20(12), 1869-1870. DOI
  2024	Altree, T. J., Toson, B., Loffler, K. A., Ekström, M., Currow, D. C., & Eckert, D. J. (2024). Low-Dose Morphine Does Not Cause Sleepiness in COPD: A Secondary Analysis of a Randomized Trial. American Journal of Respiratory and Critical Care Medicine, 210(9), 1113-1122. DOI Scopus2 Europe PMC2
  2024	Altree, T. J., & Barateau, L. (2024). The borderland down under. Journal of Clinical Sleep Medicine, 20(12), 1869-1870. DOI
  2024	Altree, T. J., & Currow, D. C. (2024). The use of opioids in late-stage COPD—Where are we now?. Respirology, 29(12), 1017-1019. DOI
  2023	Altree, T. J., Aishah, A., Loffler, K. A., Grunstein, R. R., & Eckert, D. J. (2023). The norepinephrine reuptake inhibitor reboxetine alone reduces obstructive sleep apnea severity: a double-blind, placebo-controlled, randomized crossover trial. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 19(1), 85-96. DOI Scopus17 WoS5 Europe PMC12
  2023	Osman, A. M., Mukherjee, S., Altree, T. J., Delbeck, M., Gehring, D., Hahn, M., . . . Eckert, D. J. (2023). Topical Potassium Channel Blockage Improves Pharyngeal Collapsibility: A Translational, Placebo-Controlled Trial. Chest, 163(4), 953-965. DOI Scopus17 WoS4 Europe PMC7
  2023	Osman, A. M., Altree, T. J., & Eckert, D. J. (2023). The scent of love is in the air(way): a potential drug target for sleep apnea?. Sleep, 46(4), 1-4. DOI Scopus4 WoS1 Europe PMC1
  2023	Aishah, A., Tong, B. K. Y., Osman, A. M., Pitcher, G., Donegan, M., Kwan, B. C. H., . . . Eckert, D. J. (2023). Stepwise Add-on and Endotype-informed Targeted Combination Therapy to Treat Obstructive Sleep Apnea: A Proof-of-Concept Study. Annals of the American Thoracic Society, 20(9), 1316-1325. DOI Scopus12 Europe PMC7
  2022	Aishah, A., Loffler, K. A., Toson, B., Mukherjee, S., Adams, R. J., Altree, T. J., . . . Eckert, D. J. (2022). One Month Dosing of Atomoxetine plus Oxybutynin in Obstructive Sleep Apnea: A Randomized, Placebo-controlled Trial.. Annals of the American Thoracic Society, 20(4), 584-595. DOI Scopus15 WoS3 Europe PMC10
  2022	Altree, T. J., & Eckert, D. J. (2022). Obstructive sleep apnea endotypes and their postoperative relevance. International Anesthesiology Clinics, 60(2), 1-7. DOI Scopus4 WoS1 Europe PMC3
  2021	Altree, T. J., Chung, F., Chan, M. T. V., & Eckert, D. J. (2021). Vulnerability to postoperative complications in obstructive sleep apnea: importance of phenotypes. Anesthesia and Analgesia, 132(5), 1328-1337. DOI Scopus24 WoS12 Europe PMC14
  2021	Altree, T. J., Bartlett, D. J., Marshall, N. S., Hoyos, C. M., Phillips, C. L., Birks, C., . . . Cayanan, E. A. (2021). Predictors of weight loss in obese patients with obstructive sleep apnea. Sleep and Breathing, 45(5), 753-762. DOI
  2019	Altree, T., Bussell, L., Nguyen, P., & Johnston, S. (2019). Adverse cardiac outcomes after pulmonary function testing with recent myocardial infarction. Respiratory Medicine, 155, 49-50. DOI Scopus5 WoS3 Europe PMC4
  2018	Altree, T. J., Jersmann, H., & Nguyen, P. (2018). Persistent air leak successfully treated with endobronchial valves and digital drainage system. Respirology Case Reports, 6(8), e00368-1-e00368-3. DOI Scopus1 Europe PMC2
  2013	Altree, T., & Galletly, C. (2013). Laxative use and altered drug absorption. Australian and New Zealand Journal of Psychiatry, 47(7), 686. DOI Scopus3 WoS2 Europe PMC1

• Book Chapters

  Year	Citation
  2022	Altree, T. J., Catcheside, P. G., Mukherjee, S., & Eckert, D. J. (2022). Pharmacological Management of Sleep-Disordered Breathing. In Control of Breathing during Sleep (pp. 221-232). CRC Press. DOI

• Conference Papers

  Year	Citation
  2024	Fitton, J., Manners, J., Lechat, B., Loffler, K., Altree, T., Catcheside, P., . . . Eckert, D. (2024). AN INVESTIGATION OF RELATIONSHIPS BETWEEN SLEEP TIME AND QUALITY, PSYCHOLOGICAL AFFECT, AND EXERCISE PERFORMANCE IN ELITE CYCLISTS DURING THE TOUR DE FRANCE. In SLEEP MEDICINE Vol. 115 (pp. 245). ELSEVIER.
  2024	Osman, A., Mukherjee, S., Loffler, K., Altree, T., Proctor, S., Adams, R., . . . Eckert, D. (2024). A SINGLE OVERNIGHT INFUSION OF TAK-925, A SELECTIVE OREXIN 2 RECEPTOR AGONIST, REDUCES OBSTRUCTIVE SLEEP APNEA SEVERITY. In SLEEP MEDICINE Vol. 115 (pp. 326). ELSEVIER.
  2024	Osman, A., Mukherjee, S., Altree, T., Proctor, S., Adams, R., Nguyen, P., . . . Eckert, D. (2024). EFFECTS OF TAK-925 (DANAVOREXTON) A SELECTIVE OREXIN 2 RECEPTOR AGONIST ON UPPER AIRWAY COLLAPSIBILITY AND PHARYNGEAL MUSCLE ACTIVITY IN ADULTS WITH OBSTRUCTIVE SLEEP APNEA. In SLEEP MEDICINE Vol. 115 (pp. 348-349). ELSEVIER.
  2024	Altree, T., Pinczel, A., Toson, B., Loffler, K., Hudson, A., Currow, D., . . . Eckert, D. (2024). THE EFFECTS OF LOW-DOSE MORPHINE ON SLEEP AND BREATHLESSNESS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A RANDOMISED CONTROLLED TRIAL. In SLEEP MEDICINE Vol. 115 (pp. 393). ELSEVIER.
  2023	Eckert, D. J., Toson, B., Loffler, K. A., Ekstrom, M. P., Currow, D., & Altree, T. J. (2023). Sleep Quality as a Novel Mediator of Reductions in Daytime Breathlessness With Low-dose Morphine in People With Chronic Obstructive Pulmonary Disease. In Abstracts of the American-Thoracic-Society International Conference (2023, ATS) as published in the American Journal of Respiratory and Critical Care Medicine Vol. 207 (pp. A6506-1). DC, Washington: American Thoracic Society. DOI
  2022	Altree, T., Aishah, A., Loffler, K., Grunstein, R., & Eckert, D. (2022). Reboxetine improves pharyngeal collapsibility and respiratory control in obstructive sleep apnoea. In EUROPEAN RESPIRATORY JOURNAL Vol. 60 (pp. 2 pages). SPAIN, Barcelona: EUROPEAN RESPIRATORY SOC JOURNALS LTD. DOI
  2022	Aishah, A., Tong, B., Osman, A., Donegan, M., Pitcher, G., Kwan, B., . . . Eckert, D. (2022). TARGETED COMBINATION THERAPY BASED ON ENDOTYPES RESOLVES OBSTRUCTIVE SLEEP APNOEA. In SLEEP MEDICINE Vol. 100 (pp. S279). ELSEVIER.
  2022	Aishah, A., Tong, B. K., Osman, A. M., Donegan, M., Pitcher, G., Kwan, B., . . . Eckert, D. J. (2022). Endotype Targeted, Combination Therapy Resolves Obstructive Sleep Apnea. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 205 (pp. 1 page). CA, San Francisco: AMER THORACIC SOC.
  2018	Altree, T., Bussell, L., Phan, N., & Johnston, S. (2018). SAFETY OF PRE-OPERATIVE PULMONARY FUNCTION TESTING IN LEFT MAIN CORONARY ARTERY DISEASE. In RESPIROLOGY Vol. 23 (pp. 116). WILEY.

• Conference Items

  Year

  Citation

  2024

  Eckert, D. J., Tong, B. K. Y., Aishah, A., Naik, G., Chiang, A., Pitcher, G., . . . Osman, A. (2024). Stepwise and Targeted Therapy to Treat Sleep Apnea: A Novel, Physiology-informed, Personalised Approach Using Oral Appliance Therapy Plus Combination Therapy in Incomplete Responders. Poster session presented at the meeting of Abstracts of the International Conference of the American Thoracic Society (ATS 2024), as published in American Journal of Respiratory and Critical Care Medicine. San Diego, CA: American Thoracic Society. DOI

I give annual lectures to the intern and year 3 medical school student cohorts at The Queen Elizabeth Hospital. I often give invited presentations on my research, such as: 

Teaching old drugs new tricks: opioids, OSA and surgery. The Stanford University Sleep Surgery group meeting. Virtual: based at Stanford University, California. 29 May 2024.  

Phenotypes in obstructive sleep apnea. The Society of Anesthesia and Sleep Medicine Annual Scientific Meeting. Virtual: based in San Diego, California. 7 October 2021  

Vulnerability to postoperative complications in obstructive sleep apnea: the importance of phenotypes. The International Anesthesia Research Society webinar on sleep medicine. Virtual: based in San Francisco, California. 4 June 2021  

• Email: thomas.altree@adelaide.edu.au