Postdoctoral Research Fellow
Adelaide Medical School
Faculty of Health and Medical Sciences
Dr Thomas A. Agbaedeng is a postdoctoral fellow with a keen interest in mechanisms driving the development of cardiac arrhythmias. In his postdoc, Dr Agbaedeng investigates the mechanistic links between gut microbiota and cardiac arrhythmogenesis in rat models of hypertension and metabolic syndrome. Using next-generation sequencing tools (including 16S rRNA amplicon sequencing of microbes) and molecular techniques, Dr Agbaedeng aims to determine the unique signature of gut microbiome predisposing to cardiometabolic sequelae. This, Dr Agbaedeng believes, would help us to truly understand and appreciate the implication of the Gut-Heart-Axis, especially as they pertain to atrial electrophysiological remodelling and arrhythmia development.
Thomas Agbaedeng recently completed his PhD studies at the Centre for Heart Rhythm Disorders, The University of Adelaide. Using multimodal approach of meta-analysis and pre-clinical experimental models, his PhD research has provided many insightful findings on the risks and mechanisms of atrial fibrillation and sudden cardiac death in obesity. His PhD work has been presented for several Young Investigator Awards, including winning 1st Prize in the Young Investigator Award competition at the European Heart Rhythm Association Congress, Barcelona. His impressive PhD research has also been presented at major international conferences and awarded several prestigious accolades. Recently, Dr Agbaedeng was awarded the Achievement Award for the overall top winner of the CSANZ Travelling Grant to the European Society of Cardiology at the ESC Congress in Paris August/September 2019.
Dr Agbaedeng track record boasts several significant accomplishments. He has provided technical and research guidance to PhD students, and led Journal Club tutorials for MBBS Honours students. He has collaborated on projects presented at major international conferences, co-authored five published papers in high impact journals, and authored two invited editorials. Dr Agbaedeng has authored and co-authored over 30 conference papers and proceedings. He has peer-reviewed papers (more than 20 since 2019) for high-impact journals (Q1), such as Circulation; Canadian Cardiovascular Journal; Heart Rhythm; Laboratory Investigations (Springer Nature Groups); and American Journal of Physiology. His research excellence is attested in his election to State Committee of the Australian Society for Medical Research as a Media Liaison. As part of the Scientific Meeting subcommittee, Dr Agbaedeng helped convened the 2019 Annual Scientific Meeting, putting forth a fantastic event of scientific learning.
Date Position Institution name 2019 Postdoctoral Research Fellow The University of Adelaide 2019 State Scientific Meeting Subcommittee & Media Liaison Australian Society for Medical Research
Awards and Achievements
Date Type Title Institution Name Country Amount 2019 Award Young Investigator Award Asia Pacific Heart Rhythm Society Thailand — 2019 Research Award Faculty of Health and Medical Sciences Research Travel Award The University of Adelaide Australia — 2019 Achievement Achievement Award 2019 European Society of Cardiology France — 2019 Award ISHR Student Investigator Award Finalist International Society for Heart Research Australia — 2018 Award National Scientific Meeting Travel Award International Society for Heart Research Australia — 2018 Achievement Medical Staff Society Research Prize Royal Adelaide Hospital Australia — 2018 Award 1st Prize, Young Investigator Award European Heart Rhythm Association Spain — 2018 Award EHRA Congress Travel Award European Heart Rhythm Association Spain — 2017 Achievement Best Abstract Presentation Australian Society for Medical Research Australia — 2017 Award Ralph Reader Young Investigator Award Cardiac Society of Australia and New Zealand Australia — 2017 Award Young Investigator Award Heart Rhythm Society | Cardiac Electrophysiological Society United States — 2017 Award Adelaide Medical School Overseas Research Travel Award The University of Adelaide Australia — 2015 Award Peter M. Steele Electrophysiology Scholarship The University of Adelaide Australia — 2015 Award Adelaide Tuition Fee Scholarship The University of Adelaide Australia — 2011 Award Rivers State Sustainability Development Agency Undergraduate Scholarship Rivers State Government, Nigeria United Kingdom — 2010 Award Rivers State Sustainability Development Agency College Scholarship Rivers State Government, Nigeria United Kingdom —
Language Competency English Can read, write, speak, understand spoken and peer review
Date Institution name Country Title 2015 - 2019 University of Adelaide, Adelaide Australia Ph.D. 2011 - 2014 University of Brighton, Brighton United Kingdom B.Sc. (Hons.)
Year Citation 2019 Munawar, D. A., Mahajan, R., Agbaedeng, T. A., Thiyagarajah, A., Twomey, D. J., Khokar, K., . . . Sanders, P. (2019). Implication of ventricular pacing burden and atrial pacing therapies on the progression of atrial fibrillation: a systematic review and meta-analysis of randomized controlled trials. Heart rhythm, 16(8), 1204-1214.
DOI Scopus1 WoS1
2019 Oehmke, T., Wu, X., Johnston, J., Gutiérrez, C., Patel, D., Moore, E., . . . Duong, M. (2019). Unique identities. Science (New York, N.Y.), 364(6435), 22-24.
2019 Agbaedeng, T. A. (2019). Resolve to overcome obstacles. SCIENCE, 364(6435), 23. 2019 Agbaedeng, T. A., Wong, C. X., & Mahajan, R. (2019). Peri-atrial epicardial adipose tissue-a marker of thromboembolism?. Journal of Cardiovascular Electrophysiology, 30(11), 2217-2219.
2018 Agbaedeng, T., Linz, D., Lau, D., & Sanders, P. (2018). Unique role of epicardial adipose tissue in atrial fibrosis: “Atrial remodeling of a new sort”. Heart Rhythm, 15(11), 1728-1729.
DOI Scopus1 WoS1
2018 Mahajan, R., Nelson, A., Pathak, R., Middeldorp, M., Wong, C., Twomey, D., . . . Sanders, P. (2018). Electroanatomical Remodeling of the Atria in Obesity: Impact of Adjacent Epicardial Fat. JACC: Clinical Electrophysiology, 4(12), 1529-1540.
DOI Scopus15 Europe PMC4
2017 Thanigaimani, S., McLennan, E., Linz, D., Mahajan, R., Agbaedeng, T., Lee, G., . . . Lau, D. (2017). Progression and reversibility of stretch induced atrial remodeling: Characterization and clinical implications. Progress in Biophysics and Molecular Biology, 130(Pt B), 376-386.
DOI Scopus6 WoS6 Europe PMC4
2017 Thanigaimani, S., Lau, D., Agbaedeng, T., Elliott, A., Mahajan, R., & Sanders, P. (2017). Molecular mechanisms of atrial fibrosis: implications for the clinic. Expert review of cardiovascular therapy, 15(4), 247-256.
DOI Scopus18 Europe PMC9
Year Citation 2019 Agbaedeng, T., Emami, M., Munawar, D., Rattanakosit, T., Khadim, K., Elliott, A., . . . Sanders, P. (2019). Fibrosis detected by late-gadolinium enhancement cardiac MRI is associated with atrial fibrillation and poorer ablation outcome: A meta-analysis. In EUROPEAN HEART JOURNAL Vol. 40 (pp. 3528). Paris, FRANCE: OXFORD UNIV PRESS. 2019 Agbaedeng, T., Twomey, D., Thanigaimani, S., Linz, D., Lau, D., Mahajan, R., & Sanders, P. (2019). Weight fluctuation demonstrates residual atrial arrhythmogenic substrate despite final weight loss in a chronic sheep model: implications for epicardial fat and fibrofatty infiltrates. In EUROPEAN HEART JOURNAL Vol. 40 (pp. 690). Paris, FRANCE: OXFORD UNIV PRESS. 2018 Khokhar, K., Lau, D., Elliott, A., Mahajan, R., Thiyagarajah, A., Munawar, D., . . . Sanders, P. (2018). Association of aortic stiffness and new onset AF-A meta-analysis. In EUROPEAN HEART JOURNAL Vol. 39 (pp. 420). Munich, GERMANY: OXFORD UNIV PRESS. 2018 Agbaedeng, T., Mahajan, R., Thanigaimani, S., Mclennan, E., Twomey, D., Lau, D., & Sanders, P. (2018). Molecular characterisation of fibro-fatty infiltrations in the ventricular myocardium of obese sheep. In CARDIOVASCULAR RESEARCH Vol. 114 (pp. S11-S12). Vienna, AUSTRIA: OXFORD UNIV PRESS. 2017 Agbaedeng, T., Mahajan, R., Munawar, D., Elliott, A., Twomey, D., Khokhar, K., . . . Sanders, P. (2017). Risk of sudden cardiac death in obesity: A systematic review and meta-analysis of emerging evidence. In EUROPEAN HEART JOURNAL Vol. 38 (pp. 1119). OXFORD UNIV PRESS. 2017 Khokhar, K., Elliot, A., Stiles, M., Lau, D., Mahajan, R., Thiayagraj, A., . . . Sanders, P. (2017). Aortic stiffness in atrial fibrillation: q systematic review and meta-analysis. In EUROPEAN HEART JOURNAL Vol. 38 (pp. 756). OXFORD UNIV PRESS.
- TA Agbaedeng - CSANZ-BAYER Career Development Grant; the Cardiac Society of Australia and New Zealand and Bayer Pharmaceutical – 2019 to 2020
- TA Agbaedeng - Tom Simpson Trust Fund for the purchase of a Multiskan Sky Microplate Spectrophotometer Reader; Heart Foundation of Australia – January 2020 ($22,000)
Date Role Membership Country 2019 - ongoing Member American Physiological Society United States 2019 - ongoing Member American Heart Association United States 2017 - ongoing Member Cardiac Society of Australia and New Zealand, Affiliate Member Australia 2017 - ongoing Member The Australian Society for Medical Research, Student Member Australia 2017 - ongoing Member Asia Pacific Heart Rhythm Disorders, Associate Member Singapore 2017 - ongoing Member American Association for the Advancement of Science (AAAS, Student Member United States 2016 - ongoing Member The Cardiac Electrophysiology Society, Fellow-Trainee Member United States 2016 - ongoing Member Heart Rhythm Society United States
Date Role Editorial Board Name Institution Country 2019 - ongoing Member Circulation: Arrhythmia and Electrophysiology Circulation - Arrhythmia and Electrophysiology United States
Review, Assessment, Editorial and Advice
Date Title Type Institution Country 2019 - ongoing BMC Cardiovascular Disorders (Journal Impact Factor 1.95) Peer Review BioMed Central Academic Journals United Kingdom 2019 - ongoing Journal of Interventional Cardiac Electrophysiology (Journal Impact Factor 1.53) Peer Review International Journal of Cardiac Arrhythmias and Rhythm Management United States 2019 - ongoing Journal of Cardiovascular Electrophysiology (Journal Impact Factor 2.91) Peer Review Journal of Cardiovascular Electrophysiology United States 2019 - ongoing Laboratory Investigation (Journal Impact Factor 3.68) Peer Review Nature Publishing Group United States 2019 - ongoing Journal of Clinical Medicine (Journal Impact Factor 5.69) Peer Review Multidisciplinary United States 2019 - ongoing Journal of Applied Physiology (Journal Impact Factor 3.14) Peer Review American Physiological Society United States 2019 - ongoing American Journal of Physiology - Heart and Circulatory Physiology (Journal Impact Factor 4.05) Peer Review American Physiological Society United States
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