Theresa Hickey

Associate Professor Theresa Hickey

National Breast Cancer Foundation Fellow

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Associate Professor Theresa Hickey is the Scientific Program Leader of the Dame Roma Mitchell Cancer Research Laboratories (DRMCRL), Adelaide Medical School, University of Adelaide and a current National Breast Cancer Foundation Research (NCBF) Fellow.

She is internationally recognised for her research on sex hormone action in female reproductive tissues and disorders, with specific expertise in breast cancer. Theresa has pioneered new treatment strategies for breast cancer and established a patient-derived ex vivo culture methodology as a powerful new pre-clinical tool for drug development. Her group’s innovative work in this area has attracted substantial national and international interest in using the ex vivo culture technique as a pre-clinical model in several different tumour types.

Since award of her PhD on androgen receptor (AR) signalling in polycystic ovary syndrome (PCOS) from the University of Adelaide in 2006, Theresa has received continuous funding by nationally and internationally competitive grants and fellowships (NHMRC, US DoD, RAHRC, NBCF). Her current research focuses on AR signalling in human breast biology and breast cancer and extends into the field of prostate cancer, leveraging similarities between these two hormone-driven cancers to forge new insights that may benefit patients of either disease. Theresa has expertise in contemporary techniques for whole genome interrogation of transcription factor chromatin binding (ChIPseq, Chipexo) and novel proteomic techniques to interrogate protein interactions (RIME; qPLEX-RIME) and is committed to translational research by developing and employing model systems that use patient-derived material to maximize clinical relevance (PDX, MIND xenografts).

Theresa is passionate about community engagement, enjoys sharing her team’s work through the media or via active interaction with patients and consumer advocates to develop collaborative partnerships. She was instrumental in establishing a core group of consumer advocates that advise and inform DRMCRL research and is an active member of the South Australia Breast Cancer Study Group (SABCSG). This group brings together people working in all facets of breast cancer (e.g. surgeons, radiologists, nurses, researchers, oncologists, genetic counsellors) to improve patient outcomes.

The Dame Roma Mitchell Cancer Research Laboratories (DRMCRL) have an international reputation for research into sex hormone action in hormone-dependent cancers, with a particular emphasis on breast and prostate cancers.

This world-class cancer research centre brings together expertise spanning more than 30 years in basic and translational prostate and breast cancer research. It is the leading centre in Australia with a multidisciplinary team of scientists, clinicians and patient advocates dedicated to understanding how sex hormones and their receptors control tumour behaviour in both disease contexts. The information is used to understand mechanisms of resistance to existing hormonal therapies for breast and prostate cancer and in developing new strategies for disease treatment and management. Research programs span discovery, drug development and clinical translation.

A major research focus at the DRMCRL is the development of novel androgen receptor (AR) and progesterone receptor (PR) targeted therapies for breast and prostate cancer. In prostate cancer, this involves the generation of drugs to inhibit aberrant forms of the AR that drive the disease and are unresponsive to conventional androgen deprivation therapies. In the case of breast cancer, our research has led to new strategies to activate the AR or PR to inhibit growth of tumours that are driven by the estrogen receptor (ER), as well as interrogation of Selective Androgen Receptor Modulators (SARMs), which have the ability to reprogram oncogenic AR activation in ER negative breast cancer.

Our laboratory has pioneered integration of genomic technologies with unique preclinical models of human breast and prostate cancers, especially patient-derived explant cultures and xenograft models, to better understand disease mechanisms and facilitate translation of breast and prostate cancer research into the clinic.

We publish in high impact journals such as Nature, Nature Genetics, Nature Reviews Cancer, Cancer Research, Clinical Cancer Research and Oncogene. Our research is well supported by funding from nationally and internationally competitive grants. The DRMCRL offers students a wide array of projects that span cutting-edge biomedical research using contemporary pre-clinical models, genome-wide technologies and access to large proteomic/genomic databases.

We are currently actively seeking students interested in bioinformatics to interrogate these databases, with opportunities of cross faculty supervision in fields such as mathematics and machine learning.

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  • Appointments

    Date Position Institution name
    2019 - 2023 National Breast Cancer Foundation Fellow, Dame Roma Mitchell Cancer Research Laboratories University of Adelaide
    2015 - 2018 Royal Adelaide Hospital (RAH) Research Foundation 2015 Florey Fellow University of Adelaide
    2011 - 2015 US Department of Defence Breast Cancer Early Career Research Fellow University of Adelaide
    2007 - 2010 Peter Doherty NHMRC Post-doctoral Research Fellow (Academic Level B; Step 2) Interdisciplinary project between the Research Centre for Reproductive Healthy and the Department of
    2006 - 2006 Postdoctoral Research Scientist University of Adelaide
    1998 - 2006 Senior Research Officer University of Adelaide
    1997 - 1997 Research Officer University of Adelaide
    1991 - 1996 NHMRC Research Assistant Flinders University
  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2018 Award Best Scientific Presentation Award SA Breast Cancer Research Day Australia
  • Education

    Date Institution name Country Title
    2006 The University of Adelaide Australia PhD in Medicine
    1999 The University of Adelaide Australia Masters Qualifying Year (Hons equivalent)
    1982 Arcadia University United States BA in Biology
  • Research Interests

Associate Investigator: NHMRC Ideas Grant A combinatorial drug strategy to target lethal forms of breast cancer (2020-2023; $1,148,310)

Chief Investigator: NBCF Investigator Initiated Research Scheme Targeting CDK9 in triple negative and endocrine-resistant breast cancers (2019-2023; $837,547)

Chief Investigator: Movember and NBCF Breast and Prostate Cancer Linkage Grant Transforming endocrine therapy for breast and prostate cancer (2018-2021; $2,500,000)

Chief Investigator: THRF Infrastructure Support Grant Transforming therapy for breast and prostate cancer (2018-2021; $375,000)

Chief Investigator: NHMRC Project Grant Pushing AR toward better outcomes in breast and prostate cancers (2018-2021; $998,754)

Chief Investigator: Princess Alexander Hospital Research Fund Project Grant Translation of the Pathobiology and Portable, MRI-based Quantification of Mammographic Density (MD) for Improved Breast Cancer Prevention and Treatment (2018-2019)

Chief Investigator: NHMRC Project Grant The clinical significance of sex hormone crosstalk in estrogen receptor positive breast cancer (2017-2020; $1,023,132)

Associate Investigator: Emerald Clinical Trial (2016-2018; $200,000 GBP)

Chief Investigator: Cancer Australia Project Grant A novel approach to overcome therapy-resistance in breast cancer (2016-2018; $600,000 AUD)

Chief Investigator: GTx Inc. Project Grant Enobosarm for women with breast cancer: investigating the scope and mechanstic basis of therapeutic efficacy (2016-2017; $455,078 USD)

Sole Chief Investigator: Royal Adelaide Hospital Research Foundation Career Development Fellowship Selective activation of the Androgen receptor as a novel therapeutic strategy for breast cancer (2015-2017; $348,000)

Chief Investigator: NHMRC Project Grant Selective activation of androgen receptor to treat estrogen receptor positive breast cancer (2015-2017; $816,924)

2017 Early Career Mentor: Centre for Cancer Biology (CCB), University SA

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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2017 Principal Supervisor Role of the GATA3 transcription factor on AR signalling In ER-positive breast cancer Doctor of Philosophy Doctorate Full Time Mrs Leila HosseinZadeh
    2017 Principal Supervisor Androgen receptor co-regulators mediating the actions of selective androgen receptor modulators and dihydrotestosteron in TNBC Doctor of Philosophy Doctorate Full Time Mrs Ebtihal Hashem Mustafa
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2016 - 2020 Co-Supervisor The Role of MicroRNA-194 in Prostate Cancer Progression Doctor of Philosophy Doctorate Full Time Miss Rayzel Candida Fernandes
    2010 - 2016 Principal Supervisor The Role of Estrogen Receptor and the Androgen Receptor in Human Breast Cancer Doctor of Philosophy Doctorate Part Time Mrs Shalini Jindal
    2009 - 2013 Principal Supervisor Investigation into the Expression and Localisation of C-Kit and the Regulation of Kit Ligand Gene Expression in the Adult Human Ovary Doctor of Philosophy Doctorate Full Time Dr Astrud Tuck
    2008 - 2012 Principal Supervisor The Molecular Actions of Medroxyprogesterone Acetate on Androgen Receptor Signalling and the Promotion of Breast Cancer Doctor of Philosophy Doctorate Full Time Miss Aleksandra Ochnik
    2008 - 2012 Principal Supervisor The Role of Small Glutamine-Rich Tetratricopeptide Repeat Containing Protein Alpha in Female Reproductive Tissues Doctor of Philosophy Doctorate Full Time Ms Miriam Simone Butler
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  • Committee Memberships

    Date Role Committee Institution Country
    2019 - ongoing Advisory Board Member Program Organising Committee 7th PacRim International Breast & Prostate Cancer Meeting Australia
    2017 - ongoing Advisory Board Member Human Ethics Committee Bellberry Ltd Australia
    2015 - ongoing Advisory Board Member Executive Committee SA Breast Cancer Study Group Australia
  • Memberships

    Date Role Membership Country
    2015 - ongoing Advisory Board Member South Australia Breast Cancer Study Group Australia
    2005 - ongoing Member Australian Women in Endocrinology Australia
    2002 - ongoing Member Endocrine Society of Australia Australia
    2002 - ongoing Member The Endocrine Society (USA) Australia
  • Review, Assessment, Editorial and Advice

    Date Title Type Institution Country
    2019 - ongoing Editor Journal Review Journal of Investigative Medicine, United States
  • Position: National Breast Cancer Foundation Fellow
  • Phone: 83137858
  • Email: theresa.hickey@adelaide.edu.au
  • Campus: North Terrace
  • Building: Adelaide Health and Medical Sciences, floor 8
  • Room: WS8050.15
  • Org Unit: Medical Specialties

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