Dr Theresa Hickey
Dr Hickey is a Royal Adelaide Hospital (RAH) Research Foundation Career Development Fellow at the Dame Rome Mitchell Cancer Research Laboratories (DRMCRL), School of Medicine, University of Adelaide. She was the single recipient of this highly competitive award. Dr Hickey was awarded a PhD in Medicine by the University of Adelaide in December 2006 for research on androgen receptor (AR) signalling in polycystic ovary syndrome (PCOS), receiving the Vice Chancellor’s special commendation for contribution to field of study. Her work in the Research Centre for Reproductive Health at the University of Adelaide spanned more than 10 years, evolving through the positions of Senior Research Officer, PhD Student and early Post-Doctoral Scientist. During this time, Dr Hickey performed internationally recognized research on AR signalling in human ovarian tissues, with 4 highly cited (~300) publications arising from her PhD and a land-mark paper as senior author on PCOS published in the Lancet (2007; 410 citations; marked as a Highly Cited paper in Web of Science). Upon receipt of an NHMRC postdoctoral award in 2007, Dr Hickey transferred to the DRMCRL, where she continued work on ovarian biology and began work in human breast tissues. Dr Hickey’s current research focuses on AR signalling in human breast biology and breast cancer, funded up to 2020 by various awards including a highly competitive fellowship from the US DOD (achieving the highest score that year) and research grants from the NHMRC, Cancer Australia and National Breast Cancer Foundation, with continuous funding as a CI from 2007-2020. Dr Hickey’s innovative work in this area has attracted substantial national and international interest as evidenced by invited lectures, publications, and professional activities. From July 2012-Dec 2014, Dr Hickey was a visiting academic at Cancer Research UK, Cambridge Institute, performing collaborative work with A/Prof Jason Carroll, a world leader in molecular determinants of estrogen signalling in breast cancer. During this time, she developed expertise in contemporary techniques for whole genome interrogation of transcription factor chromatin binding (ChIPseq, Chipexo) and novel proteomic techniques to interrogate protein interactions (RIME; SILAC-RIME). To date, Dr Hickey has published 42 peer-reviewed manuscripts and 4 book chapters in her fields of research. Her ongoing collaboration with A/Prof Carroll’s laboratory in Cambridge has resulted in a recent Nature paper (2015), and co-authorship of a paper in Nature Genetics (2016) with another Cambridge colleague, Dr. Kerstin Meyer, both of which received extensive media coverage both nationally and internationally.
A major contribution to the field of breast cancer in the past 5 years has been application of a novel ex vivo culture technique that sustains architecture and functionality of clinical human breast tissues to (a) demonstrate the technique is a valuable preclinical model for evaluating new drugs (Cell Cycle, 2012); (b) demonstrate that the androgen receptor (AR) can inhibit estrogen receptor (ER)-mediated growth (Menopause, 2014); (c) show that AR target therapy upregulates AR variants involved in therapy resistance (Oncotarget, 2015); (d) show that progestin inhibits estrogen-stimulated proliferation of primary ER+ breast tumours (Nature, 2015; considered the key evidence for clinical relevance of the study); (e) define an androgen-regulated transcriptome in normal and malignant breast tissues to identify AR biomarkers of response to AR target therapies (Nature; pending submission). This work has led to considerable interest in using the ex vivo culture technique as a pre-clinical model in several different tumour types and invitations to speak worldwide.
|2015 - 2018||Royal Adelaide Hospital (RAH) Research Foundation 2015 Florey Fellow||University of Adelaide|
|2011 - 2015||US Department of Defence Breast Cancer Early Career Research Fellow||University of Adelaide|
|2007 - 2010||Peter Doherty NHMRC Post-doctoral Research Fellow (Academic Level B; Step 2)||Interdisciplinary project between the Research Centre for Reproductive Healthy and the Department of Medicine, Hanson Institute/IMVS/University of Adelaide|
|2006 - 2006||Postdoctoral Research Scientist||University of Adelaide|
|1998 - 2006||Senior Research Officer||University of Adelaide|
|1997 - 1997||Research Officer||University of Adelaide|
|1991 - 1996||NHMRC Research Assistant||Flinders University|
|2017||Paltoglou, S., Das, R., Townley, S., Hickey, T., Tarulli, G., Coutinho, I. ... Selth, L. (2017). Novel androgen receptor coregulator GRHL2 exerts both oncogenic and antimetastatic functions in prostate cancer. Cancer Research, 77, 13, 3417-3430.
|2017||Carroll, J., Hickey, T., Tarulli, G., Williams, M. & Tilley, W. (2017). Deciphering the divergent roles of progestogens in breast cancer. Nature Reviews Cancer, 17, 1, 54-64.
|2016||Hu, D., Selth, L., Tarulli, G., Meech, R., Wijayakumara, D., Chanawong, A. ... Hickey, T. (2016). Androgen and estrogen receptors in breast cancer coregulate human UDP-glucuronosyltransferases 2B15 and 2B17. Cancer Research, 76, 19, 5881-5893.
|2016||Philp, L., Day, T., Butler, M., Laven-Law, G., Jindal, S., Hickey, T. ... Tilley, W. (2016). Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) ablation limits offspring viability and growth in mice. Scientific Reports, 6, 1, 28950-1-28950-14.
|2016||Lim, E., Tarulli, G., Portman, N., Hickey, T., Tilley, W. & Palmieri, C. (2016). Pushing estrogen receptor around in breast cancer. Endocrine-Related Cancer, 23, 12, T227-T241.
|2016||Singhal, H., Greene, M., Tarulli, G., Zarnke, A., Bourgo, R., Laine, M. ... Greene, G. (2016). Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer. Science Advances, 2, 6, e1501924-e1501924.
|2015||Mohammed, H., Russell, I., Stark, R., Rueda, O., Hickey, T., Tarulli, G. ... Carroll, J. (2015). Progesterone receptor modulates ERα action in breast cancer. Nature, 523, 7560, 313-317.
|2015||Tarulli, G., Laven-Law, G., Shakya, R., Tilley, W. & Hickey, T. (2015). Hormone-sensing mammary epithelial progenitors: emerging identity and hormonal regulation. Journal of Mammary Gland Biology and Neoplasia, 20, 1-2, 75-91.
|2015||Mohammed, H., Russell, I., Stark, R., Rueda, O., Hickey, T., Tarulli, G. ... Carroll, J. (2015). Erratum: Progesterone receptor modulates ERα action in breast cancer (Nature (2015) 523 313-317 DOI:10.1038/nature14583). Nature, 526, 7571, 144-.
|2015||Hickey, T., Irvine, C., Dvinge, H., Tarulli, G., Hanson, A., Ryan, N. ... Selth, L. (2015). Expression of androgen receptor splice variants in clinical breast cancers. Oncotarget, 6, 42, 44728-44744.
|2015||Castro, M., De Santiago, I., Campbell, T., Vaughn, C., Hickey, T., Ross, E. ... Meyer, K. (2015). Regulators of genetic risk of breast cancer identified by integrative network analysis. Nature Genetics, 48, 1, 12-21.
|2015||Tuck, A., Robker, R., Norman, R., Tilley, W. & Hickey, T. (2015). Expression and localisation of c-kit and KITL in the adult human ovary. Journal of Ovarian Research, 8, 1, 31-1-31-12.
|2014||Robinson, J., Hickey, T., Warren, A., Vowler, S., Carroll, T., Lamb, D. ... Carroll, J. (2014). Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype. Oncogene, 33, 50, 5666-5674.
|2014||Tuck, A. R., Mottershead, D. G., Fernandes, H. A., Norman, R. J., Tilley, W. D., Robker, R. L. & Hickey, T. E. (2014). Mouse GDF9 decreases KITL gene expression in human granulosa cells. Endocrine, 2014, 2, 1-10.
|2014||Ochnik, A., Moore, N., Jankovic-Karasoulos, T., Bianco-Miotto, T., Ryan, N., Thomas, M. ... Hickey, T. (2014). Antiandrogenic actions of medroxyprogesterone acetate on epithelial cells within normal human breast tissues cultured ex vivo. Menopause, 21, 1, 79-88.
|2014||Hu, D., Hickey, T., Irvine, C., Wijayakumara, D., Lu, L., Tilley, W. ... MacKenzie, P. (2014). Identification of androgen receptor splice variant transcripts in breast cancer cell lines and human tissues. Hormones and Cancer, 5, 2, 61-71.
|2014||McNamara, K., Moore, N., Hickey, T., Sasano, H. & Tilley, W. (2014). Complexities of androgen receptor signalling in breast cancer. Endocrine-Related Cancer, 21, 4, T161-T181.
|2014||Tarulli, G., Butler, L., Tilley, W. & Hickey, T. (2014). Bringing androgens up a NOTCH in breast cancer. Endocrine-Related Cancer, 21, 4, T183-T202.
|2013||Butler, M., Yang, X., Ricciardelli, C., Liang, X., Norman, R., Tilley, W. & Hickey, T. (2013). Small glutamine-rich tetratricopeptide repeat-containing protein alpha is present in human ovaries but may not be differentially expressed in relation to polycystic ovary syndrome. Fertility and Sterility, 99, 7, 2076-2083.
|2013||Butler, M., Ricciardelli, C., Tilley, W. & Hickey, T. (2013). Androgen receptor protein levels are significantly reduced in serous ovarian carcinomas compared with benign or borderline disease but are not altered by cancer stage or metastatic progression. Hormones and Cancer, 4, 3, 154-164.
|2013||Philp, L., Butler, M., Hickey, T., Butler, L., Tilley, W. & Day, T. (2013). SGTA: A new player in the molecular co-chaperone game. Hormones and Cancer, 4, 6, 343-357.
|2012||Dean, J., McClendon, A., Hickey, T., Butler, L., Tilley, W., Witkiewicz, A. & Knudsen, E. (2012). Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors. Cell Cycle, 11, 14, 2756-2761.
|2012||Moore, N., Hickey, T., Butler, L. & Tilley, W. (2012). Multiple nuclear receptor signaling pathways mediate the actions of synthetic progestins in target cells. Molecular and Cellular Endocrinology, 357, 1-2, 60-70.
|2012||Moore, N., Buchanan, G., Harris, J., Selth, L., Bianco-Miotto, T., Hanson, A. ... Tilley, W. (2012). An androgen receptor mutation in the MDA-MB-453 cell line model of molecular apocrine breast cancer compromises receptor activity. Endocrine-Related Cancer, 19, 4, 599-613.
|2012||Hickey, T., Robinson, J., Carroll, J. & Tilley, W. (2012). Minireview: the androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?. Molecular Endocrinology, 26, 8, 1252-1267.
|2011||Pasquali, R., Stener-Victorin, E., Yildiz, B., Duleba, A., Hoeger, K., Mason, H. ... Legro, R. (2011). PCOS Forum: Research in polycystic ovary syndrome today and tomorrow. Clinical Endocrinology, 74, 4, 424-433.
|2011||Janse, F., Eijkemans, M., Goverde, A., Lentjes, E., Hoek, A., Lambalk, C. ... Norman, R. (2011). Assessment of androgen concentration in women: liquid chromatography-tandem mass spectrometry and extraction RIA show comparable results. European Journal of Endocrinology, 165, 6, 925-933.
|2011||Augello, M., Hickey, T. & Knudsen, K. (2011). FOXA1: Master of steroid receptor function in cancer. EMBO Journal, 30, 19, 3885-3894.
|2010||Ochnik, A. M., Jankovic-Karasoulos, T., Cops, E. J., Birrell, S. N., Butler, L. M., Jindall, S. ... Hickey, T. E. (2010). Medroxyprogesterone acetate impedes 5 alpha-dihydrotesterone induced androgen receptor signaling in normal and malignant human breast epithelial cells. CANCER RESEARCH, 70, 8 Supplement, -.
|2010||Yang, X., Dunning, K., Linyan Wu, L., Hickey, T., Norman, R., Russell, D. ... Robker, R. (2010). Identification of Perilipin-2 as a lipid droplet protein regulated in oocytes during maturation. Reproduction Fertility and Development, 22, 8, 1262-1271.
|2010||Hickey, T. & Norman, R. (2010). Biomarkers: Polycystic ovary syndrome: steroid assessment for diagnosis. Nature Reviews Endocrinology, 6, 6, 305-307.
|2009||Prodoehl, M., Hatzirodos, N., Irving-Rodgers, H., Zhao, Z., Painter, J., Hickey, T. ... Rodgers, R. (2009). Genetic and gene expression analyses of the polycystic ovary syndrome candidate gene fibrillin-3 and other fibrillin family members in human ovaries. Molecular Human Reproduction, 15, 12, 829-841.
|2007||Norman, R., Dewailly, D., Legro, R. & Hickey, T. (2007). Polycystic ovary syndrome. Lancet, 370, 9588, 685-697.
|2006||Hickey, T., Legro, R. & Norman, R. (2006). Epigenetic modification of the X chromosome influences susceptibility to polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 91, 7, 2789-2791.
|2006||Gilchrist, R., Ritter, L., Myllymaa, S., Kaivo-Oja, N., Dragovic, R., Hickey, T. ... Mottershead, D. (2006). Molecular basis of oocyte-paracrine signalling that promotes granulosa cell proliferation. Journal of Cell Science, 119, 18, 3811-3821.
|2005||Hickey, T., Marrocco, D., Amato, F., Ritter, L., Norman, R., Gilchrist, R. & Armstrong, D. (2005). Androgens augment the mitogenic effects of oocyte-secreted factors and growth differentiation factor 9 on procine granulosa cells. Biology of Reproduction, 73, 4, 825-832.
|2004||Hickey, T., Marrocco, D., Gilchrist, R., Norman, R. & Armstrong, D. (2004). Interactions between androgen and growth factors in granulosa cell subtypes of porcine antral follicles. Biology of Reproduction, 71, 1, 45-52.
|2004||Norman, R., Hickey, T., Moran, L., Boyle, J., Wang, J. & Davies, M. (2004). Polycystic ovary syndrome - diagnosis and etiology. International Congress Series, 1266, C, 225-232.
|2002||Hickey, T., Chandy, A. & Norman, R. (2002). The androgen-receptor CAG repeat polymorphism and X-chromosome inactivation in Australian Caucasian women with infertility related to polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 87, 1, 161-165.
|1996||Tilley, W. D., Buchanan, G., Hickey, T. E. & Bentel, J. M. (1996). Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence. Clinical Cancer Research, 2, 2, 277-285.|
|1995||Birrell, S., Bentel, J., Hickey, T., Ricciardelli, C., Weger, M., Horsfall, D. & Tilley, W. (1995). Androgens induce divergent proliferative responses in human breast cancer cell lines. Journal of Steroid Biochemistry and Molecular Biology, 52, 5, 459-467.
|2014||Moore, N. L., Centenera, M. M., Butler, L. M., Hickey, T. E. & Tilley, W. D. (2014). Androgens and the Androgen Receptor (AR). In E. Gelmann, C. Sawyers & F. Rauscher (Eds.), Molecular oncology: Causes of cancer and targets for treatment (pp. 378-391). United States: Cambridge University Press.
|1985||Kochhar, D. & Hickey, T. (1985). Goals and potential value of alternative teratogenicity tests. In In vitro embryotoxicity and teratogenicity tests : Joint American-Swiss Seminar on Alternative Embryotoxicity and Teratogenicity Tests, Zürich, November 12, 1984 (pp. 6-15). Karger.|
|2016||Tarulli, G. A., Laven-Law, G., Tilley, W. D. & Hickey, T. E. (2016). Unraveling an identity for the androgen receptor-expressing mammary epithelial cell. Annual Scientific Meeting of the Endocrine-Society-of-Australia. Adelaide, AUSTRALIA.|
|2012||Ochnik, A. M., Moore, N. L., Birrell, S. N., Butler, L. M., Jindal, S., Selth, L. ... Hickey, T. E. (2012). The combined actions of DHT and MPA lead to altered AR signaling in normal and malignant post-menopausal breast epithelial cells.
|2009||Jankovic-Karasoulos, T., Birrell, S., Cops, E., Jindal, S., Ochnik, A., Thomas, M. ... Hickey, T. (2009). Evaluation of Testosterone Supplementation during Anastrozole Therapy in a Breast Explant Model. 32nd Annual San Antonio Breast Cancer Symposium. San Antonio, TX.|
|2008||Hickey, T., Ocknik, A., Bianco-Miotto, T., Birrell, S., Butler, L. & Tilley, W. (2008). Functional androgen signaling in an explant model of normal human breast tissue. 41st Annual Meeting of the Society-for-the-Study-of-Reproduction. Kona, HI.
|2008||Hickey, T., Butler, M., Ricciardelli, C., Norman, R. & Tilley, W. (2008). Expression of small glutamine-rich tetratricopeptide repeat-containing protein alpha (alpha SGT), a novel regulator of androgen receptor (AR) activity, in the human ovary and fallopian tube. World Congress on Reproductive Biology. Kailua Kona, HI.
|2014||Hickey, T. E., Robinson, J. L., Moore, N. L., Russell, R., Selth, L., Rueda, O. ... Tilley, W. D. (2014). The Androgen Receptor Restricts Estrogen Receptor Alpha DNA Binding in Breast Cancer Cells.|
|2013||Tilley, W. & Hickey, T. (2013). Androgen-receptor: A two-edge sword?. European Cancer Congress 2013 - 17th ECCO / 38th ESMO / 32nd ESTRO. Amsterdam, NETHERLANDS.|
|2011||Boyle, J., Brennan, L., Brinkworth, G., Brown, W., Burger, H., Clarke, I. ... Noakes, M.; (2011); Evidence-based guideline for the assessment and management of polycystic ovary syndrome. The Jean Hailes Foundation, ISBN Print: 978-0-646-55470-9;|
CIC: NHMRC Project Grant (2017-2020); CIC: Cancer Australia Project Grant (2016-2018); Royal Adelaide Hospital Research Foundation Career Development Fellowship (2015-2017); CIB: NHMRC Project Grant (2015-2017); CIB: Cancer Australia project grant (2013-2015) CIA: US Department of Defence Breast Cancer Research Program Fellowship (2010-2014)
Supervision of Staff and Students
|2016||Principal supervisor to 3 post-doctoral researchers, one Research Associate and one Honour’s Student||Co-supervisor to two 2nd year University of Adelaide Summer Students|
Supervision of Staff and Students:
- 2016: Principal supervisor to 3 post-doctoral researchers, one Research Associate and one Honour’s Student. Co-supervisor to two 2nd year University of Adelaide Summer Students.
- 2015: Principal supervisor to 2 post-doctoral researchers and one Research Associate.
- 2014: Principal supervisor to 1 PhD student who submitted her thesis and acquired a national postdoctoral position. Overseeing 3 junior post-doctoral projects and one Research Associate.
- 2013: Principal supervisor to 1 PhD student who completed her thesis and acquired a national postdoctoral position and 1 PhD student in her final year of study. Overseeing 2 junior post-doctoral projects and one Research Assistant.
- 2012: Co-supervisor to 1 Hounour’s student who received a first class qualification. Prinicipal supervisor to 1 PhD who completed her thesis and acquired an international post-doctoral position and 2 PhD students in mid-final years of study.
- 2011: Principal supervisor to 1 PhD student who completed her thesis and acquired an international post-doctoral position and 3 PhD students still in progress.
- 2008: Principal supervisor to one Masters student, 4 PhD students (including one on a collaborative program from China), 2 Research Assistants, and 2 casual staff. One of the PhD students won the Adelaide Research & Innovation Award and another received a special commendation for her presentation at the University of Adelaide, Faculty of Health Sciences’ Postgraduate Research Day (July 2008).
- 2007 Principal supervisor to one Master’s student, two Honour’s students, and 2 Research Assistants commencing work in 2007. One of the Honour’s students had the highest marks and won the Honours Student Award from the School of Paediatrics & Reproductive Health, University of Adelaide.
- 2004-2005 Co-supervisor to two Honour’s students who are currently engaged in PhD studies at the University of Adelaide
- 2003-2006 Primary supervisor for 4 work experience students, two of whom proceeded to do an Honour’s year, one of whom became employed as a Research Assistant at the University of Adelaide, and one of whom is continuing work experience in 2007.
2003 Primary supervisor for two 3rd year Physiology students from the University of Adelaide