Thao Nguyen

Research Interests

Biochemistry and Cell Biology Cancer Cell Biology Cancer Genetics Cancer Therapy Cardiovascular Medicine and Haematology Cell Biology Haematological Tumours Haematology Cancer Biology and Clinical Oncology Translational Health Outcomes Genomics Oral Medicine and Pathology Genetics Translational and applied bioinformatics

Dr Thao Nguyen

Senior Lecturer

School of Dentistry

College of Health

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Available For Media Comment.

Dr Thao Nguyen is a cancer and precision medicine researcher whose work seeks to understand and target the biological mechanisms driving disease relapse. As a former NHMRC Peter Doherty Early Career Research Fellow and current Research Fellow at the Centre for Pharmaceutical Innovation, she leads research at the interface of stem cell biology, molecular diagnostics, cancer genomics, and therapeutic innovation.
Her research combines laboratory, translational, and clinical approaches to develop novel strategies for targeting cancer stem cells, overcoming treatment resistance, and improving outcomes for patients with acute myeloid leukaemia and other cancers. Current interests include nanomedicine, oral cancer, host-microbiome interactions, periodontal disease, and antimicrobial resistance.
With more than $2.2 million in competitive funding and over two decades of research experience, Dr Nguyen is committed to translating scientific discovery into meaningful clinical impact.

Cancer Biology

Date Position Institution name
2017 - 2017 Post-Doctoral Researcher Mesenchymal Stem Cell Laboratory, The University of Adelaide
2016 - ongoing Guest lecturer University of South Australia
2016 - 2017 Post-Doctoral Researcher Mesenchymal Stem Cell Laboratory, The University of Adelaide
2014 - 2015 Research Officer Mesenchymal Stem Cell Laboratory, The University of Adelaide
2008 - 2010 Research Officer University of Adelaide
2004 - 2008 Resarch Officer University of Adelaide
2003 - 2004 Research Officer Numico Research Australia
2003 - 2003 Research Officer Queensland Institute of Medical Research
2002 - 2002 Technical Officer (0.5FTE) Institute of Medical and Veterinary Science

Language Competency
Vietnamese Can read, write, speak, understand spoken and peer review

Date Institution name Country Title
2015 University of South Australia Australia Doctor of Philosophy
2003 University of South Australia Australia Bachelor of Medical and Pharmaceutical Biotechnology

Date Title Institution name Country
1999 Ethnic Accreditation for Teaching South Australia Ethnic School Board Australia

Year Citation
2024 Nguyen, T. M., Joyce, P., Ross, D. M., Bremmell, K., Jambhrunkar, M., Wong, S. S., & Prestidge, C. A. (2024). Combating Acute Myeloid Leukemia via Sphingosine Kinase 1 Inhibitor-Nanomedicine Combination Therapy with Cytarabine or Venetoclax. Pharmaceutics, 16(2), 209-1-209-16.
DOI Scopus9 WoS6 Europe PMC3
2023 Nguyen, T. M., Jambhrunkar, M., Wong, S. S., Ross, D. M., Joyce, P., Finnie, J. W., . . . Prestidge, C. A. (2023). Targeting Acute Myeloid Leukemia Using Sphingosine Kinase 1 Inhibitor-Loaded Liposomes.. Molecular pharmaceutics, 20(8), 3937-3946.
DOI Scopus10 WoS8 Europe PMC6
2022 Lewis, A. C., Pope, V. S., Tea, M. N., Li, M., Nwosu, G. O., Nguyen, T. M., . . . Pitson, S. M. (2022). Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia.. Blood, 139(26), 3737-3751.
DOI Scopus48 WoS42 Europe PMC46
2019 Arthur, A., Nguyen, T. M., Paton, S., Zannettino, A. C. W., & Gronthos, S. (2019). Loss of EfnB1 in the osteogenic lineage compromises their capacity to support hematopoietic stem/progenitor cell maintenance. Experimental Hematology, 69, 43-53.
DOI Scopus16 WoS15 Europe PMC15
2019 Toledo-Flores, D., Williamson, A., Schwarz, N., Fernando, S., Dimasi, C., Witt, T. A., . . . Psaltis, P. J. (2019). Vasculogenic properties of adventitial Sca-1⁺CD45⁺ progenitor cells in mice: a potential source of vasa vasorum in atherosclerosis. Scientific Reports, 9(1), 7286-1-7286-15.
DOI Scopus22 WoS22 Europe PMC22
2018 Arthur, A., Nguyen, T., Paton, S., Klisuric, A., Zannettino, A., & Gronthos, S. (2018). The osteoprogenitor-specific loss of ephrinB1 results in an osteoporotic phenotype affecting the balance between bone formation and resorption. Scientific Reports, 8(1), 12756-1-12756-12.
DOI Scopus17 WoS15 Europe PMC14
2017 Nguyen, T., Arthur, A., Zannettino, A., & Gronthos, S. (2017). EphA5 and EphA7 forward signaling enhances human hematopoietic stem and progenitor cell maintenance, migration, and adhesion via Rac1 activation. Experimental Hematology, 48, 72-78.
DOI Scopus23 WoS21 Europe PMC22
2016 Nguyen, T., Arthur, A., & Gronthos, S. (2016). The role of Eph/ephrin molecules in stromal–hematopoietic interactions. International Journal of Hematology, 103(2), 145-154.
DOI Scopus22 WoS21 Europe PMC17
2016 Arthur, A., Cakouros, D., Cooper, L., Nguyen, T., Isenmann, S., Zannettino, A., . . . Gronthos, S. (2016). Twist-1 enhances bone marrow mesenchymal stromal cell support of hematopoiesis by modulating CXCL12 expression. Stem Cells, 34(2), 504-509.
DOI Scopus21 WoS21 Europe PMC23
2016 Nguyen, T., Arthur, A., Purton, L., Hayball, J., Zannettino, A., Paton, S., . . . Gronthos, S. (2016). EphB4 enhances bone marrow stromal stem cell-mediated support of haematopoiesis. British journal of haematology, 173(30, S1,S1), 30.
2016 Nguyen, T., Arthur, A., Paton, S., Hemming, S., Panagopoulos, R., Codrington, J., . . . Gronthos, S. (2016). Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during skeletal development. Bone, 93, 12-21.
DOI Scopus20 WoS20 Europe PMC16
2016 M Nguyen, T., Arthur, A., & Gronthos, S. (2016). Eph/ephrin-mediated mesenchymal stem cell regulation of T-cell activation and function. Journal of Clinical and Cellular Immunology, 7(3), 418-1-418-7.
DOI
2015 Nguyen, T., Arthur, A., Panagopoulos, R., Paton, S., Hayball, J., Zannettino, A., . . . Gronthos, S. (2015). EphB4 expressing stromal cells exhibit an enhanced capacity for hematopoietic stem cell maintenance. Stem Cells, 33(9), 2838-2849.
DOI Scopus31 WoS31 Europe PMC27
2013 Nguyen, T., Arthur, A., Hayball, J., & Gronthos, S. (2013). Ephb and Ephrin-B interactions mediate human mesenchymal stem cell suppression of activated T-cells. Stem Cells and Development, 22(20), 2751-2764.
DOI Scopus66 WoS65 Europe PMC61
2010 Sasseville, M., Ritter, L., Nguyen, T., Liu, F., Mottershead, D., Russell, D., & Gilchrist, R. (2010). Growth differentiation factor 9 signaling requires ERK1/2 activity in mouse granulosa and cumulus cells. Journal of Cell Science, 123(18), 3166-3176.
DOI Scopus62 WoS56 Europe PMC54
2010 Hayden, M., Tabone, T., Nguyen, T., Coventry, S., Keiper, F., Fox, R., . . . Eglinton, J. (2010). An informative set of SNP markers for molecular characterisation of Australian barley germplasm. Crop and Pasture Science, 61(1), 70-83.
DOI Scopus24 WoS15
2008 Hayden, M., Nguyen, T., Waterman, A., & Chalmers, K. (2008). Multiplex-ready PCR: A new method for multiplexed SSR and SNP genotyping. BMC Genomics, 9(1), WWW 1-WWW 12.
DOI Scopus152 WoS133 Europe PMC75
2008 Hayden, M., Nguyen, T., Waterman, A., McMichael, G., & Chalmers, K. (2008). Application of multiplex-ready PCR for fluorescence-based SSR genotyping in barley and wheat. Molecular Breeding, 21(3), 271-281.
DOI Scopus104 WoS100 Europe PMC46
2007 Hayden, M. J., Nguyen, T. M., & Chalmers, K. J. (2007). Development of a set of sequence tagged microsatellites (STMs) for high throughput, marker assisted selection of the stem rust resistance gene Sr2 in bread wheat. Electronic Journal of Plant Breeding.

Year Citation
2019 Powell, J., Lewis, A., Tea, M., Nguyen, T., Wallington-Beddoe, C., Anderson, D., . . . Pitson, S. (2019). CERAMIDE EVOKES AN APOPTOTIC INTEGRATED STRESS RESPONSE IN ACUTE MYELOID LEUKEMIA. In EXPERIMENTAL HEMATOLOGY Vol. 76 (pp. S83). ELSEVIER SCIENCE INC.
2018 Nguyen, T. M., Arthur, A., & Gronthos, S. (2018). EPHA FORWARD SIGNALLINGS ENHANCE HUMAN HAEMATOPOIETIC PROGENITOR CELL MIGRATION AND ADHESION VIA RAC1 ACTIVATION. In JOURNAL OF GENE MEDICINE Vol. 20 (pp. 1 page). Univ Technol Sydney, Sydney, AUSTRALIA: WILEY.
2016 Nguyen, T. M., Arthur, A., Paton, S., Purton, L. E., & Gronthos, S. (2016). EphrinB1 expressing stromal cells exhibit an enhanced capacity for haematopoietic stem cell maintenance. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 173 (pp. 30). British Soc Haematol, Glasgow, SCOTLAND: WILEY-BLACKWELL.
2009 Sasseville, M., Nguyen, T. M., Ritter, L. J., Russell, D. L., & Gilchrist, R. B. (2009). Oocyte/GDF9 Regulation of Granulosa/Cumulus Cell Functions Requires EGF Receptor/MAPK3/1 Signaling.. In BIOLOGY OF REPRODUCTION (pp. 72). Pittsburgh, PA: SOC STUDY REPRODUCTION.
WoS2
2005 Hayden, M., Nguyen, T., & Chalmers, K. (2005). Multiplex-ready markers: A technique for high-throughput, low-cost genotyping on a semi-automated DNA fragment analyser. In 12th Australian Barley Technical Symposium Conference Proceedings, 11-14 September 2005: [CD-ROM] (pp. 9 pages). Hobart, Tasmania: Australian Barley Association.
  • Understanding the biological mechanisms involved in treatment free remission of chronic myeloid leukaemia, NHMRC - Early Career Fellowship, 01/01/2018 - 28/02/2022

Courses I teach

  • BIOL 1051 Physiology Essentials 100 (2025)
  • BIOL 1056 Biomedical Research Training (2025)
  • BIOL 2056 Fetal and Maternal Pathophysiology (2025)
  • BIOL 1007 Biology A (2024)
  • BIOL 1049 Human Physiology 100 (2024)
  • BIOL 1050 Human Physiology 101 (2024)
  • BIOL 1051 Physiology Essentials 100 (2024)
  • BIOL 2016 Genetics (2024)
  • BIOL 2058 Scientific Basis of Clinical Practice (2024)
  • HLTH 2055 UO Fundamentals of Pharmacology (2024)
  • MEDI 2008 UO Pathophysiology (2024)

Programs I'm associated with

  • IBMS - Bachelor of Medical Science

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