
Dr Thao Nguyen
Post Doctoral - Researcher
Adelaide Medical School
Faculty of Health and Medical Sciences
Dr Thao M Nguyen
NHMRC Early Career Research Fellow
Thao Nguyen’s research focuses in understanding the fundamental mechanisms involved in controlling how bone marrow derived mesenchymal stem cells (BMSC) support the process of blood cell formation and modulate immune cell responses. Of major interests are the role of Eph receptor tyrosine kinases and ephrin ligands in these processes. Her PhD work investigated the role of Eph/ephrin interactions in BMSC-mediated bone regeneration, support of haematopoiesis and immune cell regulation. The study demonstrated that EphB4, expressed by BMSC, enhances haematopoietic reconstitution following bone marrow transplantation. In addition, EphB2 and ephrin-B2, expressed by ex-vivo expanded human BMSC, mediate the suppression of activated human T-cells by interacting with their cognate binding partners expressed on the T-cells.
The role of Eph/ephrin interactions in mesenchymal stem cell-mediated support of haematopoiesis and immune cell regulation
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Appointments
Date Position Institution name 2017 - 2017 Post-Doctoral Researcher Mesenchymal Stem Cell Laboratory, The University of Adelaide 2016 - ongoing Guest lecturer University of South Australia 2016 - 2017 Post-Doctoral Researcher Mesenchymal Stem Cell Laboratory, The University of Adelaide 2014 - 2015 Research Officer Mesenchymal Stem Cell Laboratory, The University of Adelaide 2008 - 2010 Research Officer University of Adelaide 2004 - 2008 Resarch Officer University of Adelaide 2003 - 2004 Research Officer Numico Research Australia 2003 - 2003 Research Officer Queensland Institute of Medical Research 2002 - 2002 Technical Officer (0.5FTE) Institute of Medical and Veterinary Science -
Awards and Achievements
Date Type Title Institution Name Country Amount 2018 Award Travel Grant The National Stem Cell Foundation of Australia Australia 850 2018 Fellowship NHMRC Early Career Fellowship NHMRC Australia 2018 Fellowship Heart Foundation Early Career Fellowship (Unable to accept) Heart Foundation Australia 2016 Award Travel grant School of Medicine, The University of Adelaide Australia $3000 2015 Award Travel Grant National Stem Cell Foundation of Australia Australia $1000 2015 Award Travel grant Haematology Society of Australia and New Zealand Australia $1000 2015 Award Educational Grant Haematology Society of Australia and New Zealand Australia 2015 Recognition Finalist of the Albert Baikie Memorial Award HAA Annual Scientific Meeting Australia 2015 Recognition Finalist of the Ross Wishart Memorial Award ASMR Annual Scientific Meeting Australia 2014 Award Travel Grant National Stem Cell Foundation of Australia Australia $1000 2014 Award Best PhD Oral Presentation Award ASSCR and Cellular Therapy meeting Australia 2013 Award Travel Grant National Stem Cell Foundation of Australia Australia 2013 Award Travel Grant International Society for Hematology and Stem Cell United States 2013 Award Best PhD Poster Award ASMR Annual Scientific Meeting Australia 2010 Award Post Graduate Award The University of Adelaide Australia $22,000 per year for three years 2010 Scholarship Top-up PhD scholarship University of South Australia Australia 2010 Award Post-Graduate Award University of South Australia Australia 1999 Scholarship Equity HECS Exemption University of South Australia Australia -
Language Competencies
Language Competency Vietnamese Can read, write, speak, understand spoken and peer review -
Education
Date Institution name Country Title 2015 University of South Australia Australia Doctor of Philosophy 2003 University of South Australia Australia Bachelor of Medical and Pharmaceutical Biotechnology -
Certifications
Date Title Institution name Country 1999 Ethnic Accreditation for Teaching South Australia Ethnic School Board Australia -
Research Interests
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Journals
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Conference Papers
Year Citation 2018 Nguyen, T. M., Arthur, A., & Gronthos, S. (2018). EPHA FORWARD SIGNALLINGS ENHANCE HUMAN HAEMATOPOIETIC PROGENITOR CELL MIGRATION AND ADHESION VIA RAC1 ACTIVATION. In JOURNAL OF GENE MEDICINE Vol. 20 (pp. 1 page). Univ Technol Sydney, Sydney, AUSTRALIA: WILEY. 2016 Nguyen, T., Arthur, A., Purton, L., Hayball, J., Zannettino, A., Paton, S., . . . Gronthos, S. (2016). EphB4 enhances bone marrow stromal stem cell-mediated support of haematopoiesis. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 173 (pp. 30). British Soc Haematol, Glasgow, SCOTLAND: WILEY-BLACKWELL. 2016 Nguyen, T., Arthur, A., Paton, S., Purton, L., & Gronthos, S. (2016). EphrinB1 expressing stromal cells exhibit an enhanced capacity for haematopoietic stem cell maintenance. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 173 (pp. 30). British Soc Haematol, Glasgow, SCOTLAND: WILEY-BLACKWELL. 2009 Sasseville, M., Nguyen, T. M., Ritter, L. J., Russell, D. L., & Gilchrist, R. B. (2009). Oocyte/GDF9 Regulation of Granulosa/Cumulus Cell Functions Requires EGF Receptor/MAPK3/1 Signaling.. In BIOLOGY OF REPRODUCTION (pp. 72). Pittsburgh, PA: SOC STUDY REPRODUCTION.
WoS22005 Hayden, M., Nguyen, T., & Chalmers, K. (2005). Multiplex-ready markers: A technique for high-throughput, low-cost genotyping on a semi-automated DNA fragment analyser. In 12th Australian Barley Technical Symposium Conference Proceedings, 11-14 September 2005: [CD-ROM] (pp. 9 pages). Hobart, Tasmania: Australian Barley Association. -
Conference Items
Competitive Research Funding
National Competitive Schemes
Date | Project/No. | Investigators | Funding Body | Amount |
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2016 | Travel grant - to present at the ISSCR Meeting, San Francisco, USA | School of Medicine, the University of Adelaide | ||
2015 | Travel grant - to present at the HAA Meeting, Adelaide, Australia | Haematology Society of Australia and New Zealand (HSANZ) | ||
2015 | HSANZ Educational grant | Haematology Society of Australia and New Zealand (HSANZ) | ||
2015 | Travel grant to present at the Australian Society for Stem Cell Research (ASSCR) 8th Annual Meeting, New South Wales, Australia | The National Stem Cell Foundation of Australia (NSCFA) | ||
2014 | Travel grant - to present at the ASSCR 7th Annual Meeting, Victoria, Australia | The National Stem Cell Foundation of Australia (NSCFA) | ||
2013 | Travel grant - to present at the 42nd ISEH annual scientific meeting, Vienna, Austria | International Society for Hematology and Stem Cells (ISEH) | ||
2013 | Travel grant - to present at the ASSCR 6th Annual Meeting, Brisbane, Australia | The National Stem Cell Foundation of Australia (NSCFA) |
Guest Lecturer: Cancer Biology (third year undergraduate course of the Bachelor of Biomedical Research Program – University of South Australia).
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Committee Memberships
Date Role Committee Institution Country 2016 - ongoing Member Conference Convenor The Australian Society for Medical Research Australia 2016 - ongoing Member Conference organising committee Australian Society for Medical Research Australia 2016 - ongoing Member Communication Committee The Australasian Society for Stem Cell Research (ASSCR) Australia 2016 - ongoing Member Marketing Task Force Committee International Society of Hematology and Stem Cells 2015 - ongoing Member The Haematology Society of Australia and New Zealand Australia 2015 - ongoing Member International Society for Stem Cell Research (ISSCR) 2013 - ongoing Member The International Society of Hematology and Stem Cells (ISEH) 2012 - ongoing Member The Australasian Society for Stem Cell Research (ASSCR) Australia 2011 - ongoing Member The Australian Society for Medical Research (ASMR) Australia -
Memberships
Date Role Membership Country 2016 - ongoing Member The International Society for Stem Cell Research United States 2015 - ongoing Member The Haematology Society of Australia and New Zealand Australia 2013 - ongoing Member The International Society of Hematology and Stem Cells United States 2012 - ongoing Member The Australasian Society for Stem Cell Research Australia 2011 - ongoing Member The Australian Society for Medical Research Australia -
Community Engagement
Date Title Engagement Type Institution Country 2018 - ongoing The International Society for Stem Cell Research Junior Investigators Committee Scientific Community Engagement The International Society for Stem Cell Research United States -
Editorial Boards
Date Role Editorial Board Name Institution Country 2016 - ongoing Member PLoS One 2016 - ongoing Member Hematology 2016 - ongoing Member Biology of Blood and Marrow Transplantation 2016 - ongoing Member Blood
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