Thanh Loc Nguyen

Dr Thanh Loc Nguyen

Grant-Funded Researcher, TI&I Program

South Australian Immunogenomics Cancer Institute

Faculty of Health and Medical Sciences

Dr. Thanh Loc Nguyen completed his doctoral studies in 2021 at Sungkyunkwan University (Seoul, Republic of Korea) under the supervision of Prof. Jaeyun Kim. His research focuses on micro and nanoparticles for drug delivery and immunotherapy. Afterward, he was appointed as a Brain Korea 21 postdoctoral research fellow in the same group, where he worked on developing vaccines for the treatment of cancer, multiple sclerosis, and asthma. His research resulted in 2 US patents and was published in high-impact journals, including Nature Communications, Advanced Materials, ACS Nano, and Biomaterials. From 2021 to 2023, he was awarded the Creative Challenge Research funding grants from the National Research Foundation of Korea for his postdoctoral studies.

Dr. Nguyen has a keen interest in understanding the fundamental chemistry of materials that govern their characteristics and interactions with the immune system, particularly with dendritic cells and T cells. Dendritic cells act as sentinels of our immunity, capable of initiating or suppressing immune responses through their interactions with T cells. Dr. Nguyen has joined the Yang lab at SAiGENCI as a Grant-Funded Researcher (Level B) with the aim of developing biomaterials for enhanced cancer immunotherapy.

Research interests

- Cancer Immunotherapy

- Immune-biomaterials interactions

- Immunoengineering

- Tissue engineering and regenerative medicine

 

  • Journals
    Year Citation
    2024 Nguyen, T. L., Phan, N. M., & Kim, J. (2024). Administration of ROS-Scavenging Cerium Oxide Nanoparticles Simply Mixed with Autoantigenic Peptides Induce Antigen-Specific Immune Tolerance against Autoimmune Encephalomyelitis. ACS Applied Materials and Interfaces, 16(26), 33106-33120.
    DOI Scopus1 Europe PMC1
    2024 Trinh, T. A., Nguyen, T. L., & Kim, J. (2024). Lignin-Based Antioxidant Hydrogel Patch for the Management of Atopic Dermatitis by Mitigating Oxidative Stress in the Skin. ACS Applied Materials and Interfaces, 16(26), 33135-33148.
    DOI
    2024 Im, J., Choi, Y., Nguyen, T. L., Kim, M. K., & Kim, J. (2024). Injectable Mesocellular Foam Silica Microparticles with a Dual Role of Cell-Recruiting Scaffolds and Intracellular Delivery Vehicles for Enhanced Cancer Vaccine. Advanced Functional Materials, 34(25), 11 pages.
    DOI
    2024 Phan, N. M., Nguyen, T. L., Choi, Y., Mo, X. W., Trinh, T. A., Yi, G. R., & Kim, J. (2024). High Cellular Internalization of Virus-Like Mesoporous Silica Nanoparticles Enhances Adaptive Antigen-Specific Immune Responses against Cancer. ACS Applied Materials and Interfaces, 16(35), 45917-45928.
    DOI
    2024 Mo, X. W., Phan, N. M., Nguyen, T. L., & Kim, J. (2024). H<inf>2</inf>O<inf>2</inf> Self-Supplying CaO<inf>2</inf> Nanoplatform Induces Ca<sup>2+</sup> Overload Combined with Chemodynamic Therapy to Enhance Cancer Immunotherapy. ACS Applied Materials and Interfaces, 16(43), 58337-58345.
    DOI
    2023 Phan, N. M., Nguyen, T. L., Shin, H., Trinh, T. A., & Kim, J. (2023). ROS-Scavenging Lignin-Based Tolerogenic Nanoparticle Vaccine for Treatment of Multiple Sclerosis. ACS Nano, 17(24), 24696-24709.
    DOI Scopus5 Europe PMC1
    2023 Trinh, T. A., Le, T. M. D., Nguyen, H. T. T., Nguyen, T. L., Kim, J., Huynh, D. P., & Lee, D. S. (2023). pH-temperature Responsive Hydrogel-Mediated Delivery of Exendin-4 Encapsulated Chitosan Nanospheres for Sustained Therapeutic Efficacy in Type 2 Diabetes Mellitus. Macromolecular Bioscience, 23(11), 12 pages.
    DOI Scopus2
    2022 Nguyen, T. L., & Kim, J. (2022). Nanoparticle-Based Tolerogenic Vaccines for the Treatment of Autoimmune Diseases: A Review. ACS Applied Nano Materials, 5(5), 6013-6028.
    DOI Scopus6
    2022 Phan, V. H. G., Murugesan, M., Manivasagan, P., Nguyen, T. L., Phan, T. H., Luu, C. H., . . . Thambi, T. (2022). Injectable Hydrogel Based on Protein-Polyester Microporous Network as an Implantable Niche for Active Cell Recruitment. Pharmaceutics, 14(4), 17 pages.
    DOI Scopus12 Europe PMC6
    2022 Kim, Y. E., Choi, S. W., Kim, M. K., Nguyen, T. L., & Kim, J. (2022). Therapeutic Hydrogel Patch to Treat Atopic Dermatitis by Regulating Oxidative Stress. Nano Letters, 22(5), 2038-2047.
    DOI Scopus49 Europe PMC14
    2022 Nguyen, T. L., Choi, Y., Im, J., Shin, H., Phan, N. M., Kim, M. K., . . . Kim, J. (2022). Immunosuppressive biomaterial-based therapeutic vaccine to treat multiple sclerosis via re-establishing immune tolerance. Nature Communications, 13(1), 15 pages.
    DOI Scopus20 Europe PMC8
    2022 Phan, N. M., Nguyen, T. L., & Kim, J. (2022). Nanozyme-Based Enhanced Cancer Immunotherapy. Tissue Engineering and Regenerative Medicine, 19(2), 237-252.
    DOI Scopus30 Europe PMC11
    2022 Ji, D., Park, J. M., Oh, M. S., Nguyen, T. L., Shin, H., Kim, J. S., . . . Kim, J. (2022). Superstrong, superstiff, and conductive alginate hydrogels. Nature Communications, 13(1), 10 pages.
    DOI Scopus198 Europe PMC29
    2021 Ji, D., Nguyen, T. L., & Kim, J. (2021). Bioinspired Structural Composite Hydrogels with a Combination of High Strength, Stiffness, and Toughness. Advanced Functional Materials, 31(28), 8 pages.
    DOI Scopus30
    2020 Nguyen, T. L., Cha, B. G., Choi, Y., Im, J., & Kim, J. (2020). Injectable dual-scale mesoporous silica cancer vaccine enabling efficient delivery of antigen/adjuvant-loaded nanoparticles to dendritic cells recruited in local macroporous scaffold. Biomaterials, 239, 11 pages.
    DOI Scopus95 Europe PMC34
    2020 Duong, H. T. T., Thambi, T., Yin, Y., Kim, S. H., Nguyen, T. L., Phan, V. H. G., . . . Lee, D. S. (2020). Degradation-regulated architecture of injectable smart hydrogels enhances humoral immune response and potentiates antitumor activity in human lung carcinoma. Biomaterials, 230, 12 pages.
    DOI Scopus83 Europe PMC32
    2020 Nguyen, T. L., Yin, Y., Choi, Y., Jeong, J. H., & Kim, J. (2020). Enhanced Cancer DNA Vaccine via Direct Transfection to Host Dendritic Cells Recruited in Injectable Scaffolds. ACS Nano, 14(9), 11623-11636.
    DOI Scopus45 Europe PMC16
    2020 Lee, J. Y., Kim, M. K., Nguyen, T. L., & Kim, J. (2020). Hollow Mesoporous Silica Nanoparticles with Extra-Large Mesopores for Enhanced Cancer Vaccine. ACS Applied Materials and Interfaces, 12(31), 34658-34666.
    DOI Scopus79 Europe PMC24
    2019 Giang Phan, V. H., Duong, H. T. T., Thambi, T., Nguyen, T. L., Turabee, M. H., Yin, Y., . . . Lee, D. S. (2019). Modularly engineered injectable hybrid hydrogels based on protein-polymer network as potent immunologic adjuvant in vivo. Biomaterials, 195, 100-110.
    DOI Scopus49 Europe PMC15
    2019 Le, T. M. D., Jung, B. K., Li, Y., Duong, H. T. T., Nguyen, T. L., Hong, J. W., . . . Lee, D. S. (2019). Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment. Biomaterials Science, 7(10), 4195-4207.
    DOI Scopus37 Europe PMC16
    2019 Nguyen, T. L., Choi, Y., & Kim, J. (2019). Mesoporous Silica as a Versatile Platform for Cancer Immunotherapy. Advanced Materials, 31(34), 17 pages.
    DOI Scopus183 Europe PMC57
    2019 Sinha, A., Choi, Y., Nguyen, M. H., Nguyen, T. L., Choi, S. W., & Kim, J. (2019). A 3D Macroporous Alginate Graphene Scaffold with an Extremely Slow Release of a Loaded Cargo for In Situ Long-Term Activation of Dendritic Cells. Advanced Healthcare Materials, 8(5), 10 pages.
    DOI Scopus33 Europe PMC14
    2019 Yin, Y., Nguyen, T. L., Wang, B., Duong, H. T. T., Lee, D. S., Kim, J. H., . . . Jeong, J. H. (2019). Simultaneous delivery of DNA vaccine and hydrophobic adjuvant using reducible polyethylenimine-functionalized graphene oxide for activation of dendritic cells. Journal of Industrial and Engineering Chemistry, 80, 870-876.
    DOI Scopus16
    2018 Duong, H. T. T., Yin, Y., Thambi, T., Nguyen, T. L., Giang Phan, V. H., Lee, M. S., . . . Lee, D. S. (2018). Smart vaccine delivery based on microneedle arrays decorated with ultra-pH-responsive copolymers for cancer immunotherapy. Biomaterials, 185, 13-24.
    DOI Scopus156 Europe PMC44
    2017 Sinha, A., Cha, B. G., Choi, Y., Nguyen, T. L., Yoo, P. J., Jeong, J. H., & Kim, J. (2017). Carbohydrate-Functionalized rGO as an Effective Cancer Vaccine for Stimulating Antigen-Specific Cytotoxic T Cells and Inhibiting Tumor Growth. Chemistry of Materials, 29(16), 6883-6892.
    DOI Scopus29

  • Patents
    Year Citation
    2024 Nguyen, T. L., & Jaeyun, K. (2024). US 11,890,332 B2, Dual-scale porous silica particle-based composition for preventing or treating cancer. United States.
    2023 Nguyen, T. L., & Jaeyun, K. (2023). US 2023/0241190 A1, Vaccine for treating multiple sclerosis. United States.
  • 2021.03 - 2024.02: Brain Korea 21 Postdoctoral Fellowship
  • 2021.06 - 2022.05: National Research Foundation of Korea (NRF, 2021R1I1A1A01059165), Role: PI, Grant amount: 70M KRW
  • 2022.06 - 2023.05: National Research Foundation of Korea (NRF, 2022R1I1A1A01073332), Role: PI, Grant amount: 70M KRW

2024 Spring semester: Advanced Engineering of Biomaterials (4420_BIOPRENG_7109), The University of Adelaide

  • Review, Assessment, Editorial and Advice
    Date Title Type Institution Country
    2024 - ongoing Nature Nanotechnology Peer Review N/A -
    2023 - ongoing Journal of Nanobiotechnology Peer Review N/A -
    2023 - ongoing Cancer Immunology, Immunotherapy Peer Review N/A -
  • Position: Grant-Funded Researcher, TI&I Program
  • Phone: 83134426
  • Email: thanhloc.nguyen@adelaide.edu.au
  • Campus: North Terrace
  • Org Unit: South Australian Immunogenomics Cancer Institute
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