Thanh Nguyen

Thanh Nguyen
Adelaide Medical School
Faculty of Health and Medical Sciences

With a background of training in Medicine (MD, Hanoi Medical University) and Medical Science (PhD, University of Adelaide), I am a basic and translation cardiovascular/imaging researcher, mastering a wide range of clinical and basic science techniques, and undertaking an overseas research fellowship in Oxford and Norwich, UK, in 2016.
My current research relates to three areas:- (i) pathogenesis and treatment of aortic valve disease, (ii) diagnosis, natural history and pathogenesis of Takotsubo (“stress”) cardiomyopathy, and (iii) mechanistic interactions with inflammatory activation and glycocalyx shedding in cardiovascular disease.

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Thanh Nguyen

With a background of training in Medicine (MD, Hanoi Medical University) and Medical Science (PhD, University of Adelaide), I am a basic and translation cardiovascular/imaging researcher, mastering a wide range of clinical and basic science techniques, and undertaking an overseas research fellowship in Oxford and Norwich, UK, in 2016.
My current research relates to three areas:- (i) pathogenesis and treatment of aortic valve disease, (ii) diagnosis, natural history and pathogenesis of Takotsubo (“stress”) cardiomyopathy, and (iii) mechanistic interactions with inflammatory activation and glycocalyx shedding in cardiovascular disease.

Contributions to the field of Research:

As regards aortic valve disease, my research has focus on

(a) The roles of inflammatory activation and impaired nitric oxide signalling in valve degeneration in  patients with Bicuspid Aortic Valve (BAV), a condition which is the most common congenital heart defect and affects approximately 1–2% adults (Figure 1). 

(b) The potential for therapeutic retardation of valve disease progression, both in the context to BAV and in anatomically normal valve.

Takotsubo cardiomyopathy: The LV ventriculography (left) resembles an octopus trap (right).
Figure 2: The left ventricle ventriculography of a patient presenting with Takotsubo cardiomyopathy (left), which resembles an octopus trap (right).
Bicuspid Aortic Valve Disease: The aortic valve has two leaflets instead of three leaflets.
Figure 1: In patients with Bicuspid Aortic Valve Disease, the aortic valve has two leaflets instead of three leaflets.

 

 

 

 

 

 

 

 

Within the area of Takotsubo cardiomyopathy (TTC) (Takotsubo means octopus trap in Japanese, see Figure 2), I have identified the utility of measuring inflammatory release of brain natriuretic peptide (BNP) and N-terminal proBNP as accessories to expedite diagnosis. I have also contributed to the concept that nitrosative stress may underlie the condition (patent arising: University of Adelaide, 2013) and have established that prolonged inflammation results in slow recovery in such patients.

I have recently investigated the potential involvement of glycocalyx shedding in a number of acute and chronic cardiovascular disorders, utilizing serial measurement of plasma concentrations of SD-1.  In acute myocardial infarction, out lab has demonstrated that  syndecan-1 (SD-1) levels, which is which is the most prevalent proteoglycan component of glycocalyx, are elevated relatively soon after the onset of symptoms, but rise sharply post reperfusion. SD-1 release also occurs in severe chronic congestive heart failure (CHF), in new onset atrial fibrillation (AF), and acute episode of TTC.  

Quality of research output:

Main contributions from publications including 2 reviews and 1 editorial on TTC are related to

(i) BNP/NT-proBNP release

(ii) Its relationship to myocardial oedema

And (iii) Its relationship to slow echographic recovery (and impaired quality of life).

The studies on NO signaling in TTC led to my being awarded a plenary presentation on this subject at recent international ADMA meeting, one of 11 international presentations to date and one oral presentation at the European Society of Cardiology meeting. 

The studies on glycocalyx shedding in TTC have recently presented at the American Heart Association Scientific meeting and published in International Journal of Cardiology in 2017.

As regards AS, a recently published case-control analysis of BAV revealed a potential role for myeloperoxidase in disease progression, as well as demonstrating the presence of endothelial dysfunction in BAV.

Appointments

Date Position Institution name
2012 Post doctoral Research Fellow University of Adelaide, Adelaide
2007 - 2008 Physician Friendship Hospital, Hanoi, Vietnam
1997 - 2004 Physician Friendship Hospital, Hanoi, Vietnam
1996 - 1997 Physician Friendship Hospital, Hanoi, Vietnam

Awards and Achievements

Date Type Title Institution Name Amount
2013 Award Heart Foundation “Tom Simpson Trust Fund”
2012 Scholarship Heart Foundation SA “E.O Myers Trust Fund”, Travelling Grant
2012 Award Cardiac Society of Australia and New Zealand: European Society of Cardiology, Travelling Grant
2010 Research Award The SA Heart Education and Research Foundation, PhD research prize
2008 - 2012 Scholarship The University of Adelaide Endeavour International Postgraduate Research Scholarship

Language Competencies

Language Competency
Vietnamese Can peer review

Education

Date Institution name Country Title
2008 - 2012 University of Adelaide, Adelaide Australia PhD
2004 - 2007 University of Adelaide, Adelaide Australia Master of Medical Science
1992 - 1996 Hanoi University, Hanoi Vietnam Bachelor of Foreign Language (English)
1990 - 1996 Hanoi Medical University, Hanoi Vietnam Doctor of Medicine

Postgraduate Training

Date Title Institution Country
2012 Postdoctoral Research University of Adelaide, Adelaide Australia

Research Interests

Cardiology, Cardiovascular Medicine and Haematology

Journals

Year Citation
2017 Nguyen, T., Liu, S., Ong, G., Stafford, I., Frenneaux, M. & Horowitz, J. (2017). Glycocalyx shedding is markedly increased during the acute phase of Takotsubo cardiomyopathy. International Journal of Cardiology, 243, 296-299.
10.1016/j.ijcard.2017.04.085
2016 Assadi-Khansari, B., Chua, S., Chapman, M., Ali, O., Nguyen, H., Horowitz, J. ... Ngo, D. (2016). Follistatin-like 3 Predicts Aortic Root Enlargement in Patients with Bicuspid Aortic Valve. Heart, Lung and Circulation, 25, S77-S78.
10.1016/j.hlc.2016.06.179
2015 Singh, K., Chong, C., Nguyen, T., Stansborough, J. & Horowitz, J. (2015). Reply: Takotsubo syndrome is a systemic, rather than merely a cardiac, disease: Possible effects on the systemic and pulmonary vasculature. Heart Lung and Circulation, 24, 4, 417-418.
10.1016/j.hlc.2014.10.010
2015 Neil, C., Nguyen, T., Singh, K., Raman, B., Stansborough, J., Dawson, D. ... Horowitz, J. (2015). Relation of delayed recovery of myocardial function after takotsubo cardiomyopathy to subsequent quality of life. American Journal of Cardiology, 115, 8, 1085-1089.
10.1016/j.amjcard.2015.01.541
2015 Surikow, S., Raman, B., Licari, J., Singh, K., Nguyen, T. & Horowitz, J. (2015). Evidence of nitrosative stress within hearts of patients dying of Tako-tsubo cardiomyopathy. International Journal of Cardiology, 189, 1, 112-114.
10.1016/j.ijcard.2015.03.416
2014 Horowitz, J. & Nguyen, T. (2014). Role of echocardiography in tako-tsubo cardiomyopathy: Beyond diagnosis?. JACC: Cardiovascular Imaging, 7, 2, 130-132.
10.1016/j.jcmg.2013.09.021
2014 Singh, K., Neil, C., Nguyen, T., Stansborough, J., Chong, C., Dawson, D. ... Horowitz, J. (2014). Dissociation of early shock in Takotsubo cardiomyopathy from either right or left ventricular systolic dysfunction. Heart, Lung and Circulation, 23, 12, 1141-1148.
10.1016/j.hlc.2014.06.010
2014 Ali, O., Chapman, M., Thanh, H., Chirkov, Y., Heresztyn, T., Mundisugih, J. & Horowitz, J. (2014). Interactions between inflammatory activation and endothelial dysfunction selectively modulate valve disease progression in patients with bicuspid aortic valve. Heart, 100, 10, 800-805.
10.1136/heartjnl-2014-305509
2014 Nguyen, T. H., Chong, C. -. R., Chan, W. P. & Horowitz, J. D. (2014). New Developments in Anti-Anginal Therapy: Roles of Ivabradine, Allopurinol and of Agents Modifying Myocardial Metabolism. World Journal of Cardiovascular Diseases, 04, 07, 368-376.
10.4236/wjcd.2014.47046
2014 Mahadavan, G., Nguyen, T. & Horowitz, J. (2014). Brain natriuretic peptide: a biomarker for all cardiac disease?. Current Opinion in Cardiology, 29, 2, 160-166.
10.1097/HCO.0000000000000036
2014 Kayacelebi, A., Nguyen, T., Neil, C., Horowitz, J., Jordan, J. & Tsikas, D. (2014). Homoarginine and 3-nitrotyrosine in patients with takotsubo cardiomyopathy. International Journal of Cardiology, 173, 3, 546-547.
10.1016/j.ijcard.2014.03.080
2014 Chong, C., Chan, W., Nguyen, T., Liu, S., Procter, N., Ngo, D. ... Horowitz, J. (2014). Thioredoxin-interacting protein: pathophysiology and emerging pharmacotherapeutics in cardiovascular disease and diabetes. Cardiovascular Drugs and Therapy, 28, 4, 347-360.
10.1007/s10557-014-6538-5
2013 Nguyen, T., Neil, C., Sverdlov, A., Ngo, D., Chan, W., Heresztyn, T. ... Horowitz, J. (2013). Enhanced NO signaling in patients with Takotsubo cardiomyopathy: short-term pain, long-term gain?. Cardiovascular Drugs and Therapy, 27, 6, 541-547.
10.1007/s10557-013-6481
2013 Chong, C., Neil, C., Nguyen, T., Stansborough, J., Law, G., Singh, K. & Horowitz, J. (2013). Dissociation between severity of takotsubo cardiomyopathy and presentation with shock or hypotension. Clinical Cardiology, 36, 7, 401-406.
10.1002/clc.22129
2013 Chong, C., Neil, C., Nguyen, T., Singh, K. & Horowitz, J. (2013). Reply. Clinical Cardiology, 36, 10, 33-.
10.1002/clc.22186
2012 Neil, C., Chong, C., Nguyen, T. & Horowitz, J. (2012). Occurrence of Tako-Tsubo cardiomyopathy in association with ingestion of serotonin/noradrenaline reuptake inhibitors. Heart, Lung & Circulation (Print Edition), 21, 4, 203-205.
10.1016/j.hlc.2011.12.004
2012 Neil, C., Nguyen, T., Sverdlov, A., Chirkov, Y., Chong, C., Stansborough, J. ... Horowitz, J. (2012). Can we make sense of takotsubo cardiomyopathy? An update on pathogenesis, diagnosis and natural history. Expert Review of Cardiovascular Therapy, 10, 2, 215-221.
10.1586/erc.11.190
2012 Nguyen, T., Horowitz, J. & Unger, S. (2012). Tachycardic vs. pharmacologic stress myocardial perfusion imaging: differential implications in multi-vessel ischemia. American Journal of Cardiovascular Disease, 2, 1, 34-42.
2012 Neil, C., Nguyen, T., Kucia, A., Crouch, B., Sverdlov, A., Chirkov, Y. ... Horowitz, J. (2012). Slowly resolving global myocardial inflammation/oedema in Tako-Tsubo cardiomyopathy: evidence from T2-weighted cardiac MRI. Heart, 98, 17, 1278-1284.
10.1136/heartjnl-2011-301481
2011 Nguyen, T., Neil, C., Sverdlov, A., Mahadevan, G., Chirkov, Y., Kucia, A. ... Horowitz, J. (2011). N-terminal pro-brain natriuretic protein levels in takotsubo cardiomyopathy. American Journal of Cardiology, 108, 9, 1316-1321.
10.1016/j.amjcard.2011.06.047
2010 Neil, C. J., Nguyen, T. H., Collings, S., Mahadavan, D., Kucia, A. M., Sverdlov, A. ... Horowitz, J. D. (2010). Tako-Tsubo Cardiomyopathy: a Slowly Resolving Pancarditis. CIRCULATION, 122, 21, -.

Conference Papers

Year Citation
2017 Nguyen, T. H. (2017). Adenylate cyclase signaling is an important post-receptor determinant of response to all P2Y12 receptor antagonists. European Society of Cardiology. Barcelona.
2017 Nguyen, T. H. (2017). Impaired activity of platelet soluble guanylate cyclase and adenylate cyclase signaling in patients with coronary vasospasm: changes during acute crises.. European Society of Cardiology. Barcelona.
2017 Nguyen, T. H. (2017). Hypotension at admission and extent of release of NT-proBNP and catecholamines are associated with increased medium-term mortality rate in Takotsubo cardiomyopathy.. European Society of Cardiology. Bardelona.
2010 Kucia, A., Neil, C., Nguyen, T., Beltrame, J., Arstall, M. & Horowitz, J. (2010). Evolution of ECG changes in Tako Tsubo Cardiomyopathy: Arrhythmias first, QT Prolongation later?. Cardiac Society of Australia and New Zealand and the International Society for Heart Research Australasian Section Annual Scientific meeting.
10.1016/j.hlc.2010.06.911
2010 Kucia, A., Neil, C., Nguyen, T., Beltrame, J., Arstall, M. & Horowitz, J. (2010). Evolution of ECG changes in tako tsubo cardiomyopathy: arrhythmias first, QT prolongation later?. ESC Congress. Stockholm, SWEDEN.
2007 Nguyen, T. H. (2007). Does induction of myocardial ischaemia by dipyridamole mimic physiological stress?. the Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand. Christchurch.

Conference Items

Year Citation
2016 Nguyen, T., Liu, S., Ong, G., Stafford, I., Frenneaux, M. & Horowitz, J. (2016). Glycocalyx shedding is markedly increased during the acute phase of Takotsubo cardiomyopathy. American Heart Association Scientific Sessions and Resuscitation Science Symposium 2016. New Orleans, LA.
2016 Assadi-Khansari, B., Chua, S., Chapman, M., Ali, O., Nguyen, H., Horowitz, J. ... Ngo, D. (2016). Follistatin-like 3 predicts aortic root enlargement in patients with bicuspid aortic valve. Congress of the European-Society-of-Cardiology (ESC). Rome, ITALY.
2015 Nguyen, T. (2015). Nitric oxide plays a janus role in the pathogenesis of stress (Tako-tsubo) cardiomyopathy.. American Heart Association Scientific meeting. Orlando.
2014 Nguyen, T. (2014). Heterogeneity of disease progression rates in patients with bicuspid aortic valve: is there a suitable bio-marker?. American Heart Association Scientific meeting. Orlando.
2014 Nguyen, T. (2014). Systemic inflammatory activation and endothelial dysfunction predict development of aortic valve stenosis in bicuspid aortic valve. World Congress of Cardiology. Melbourne.
2013 Nguyen, T. (2013). ncreased myocardial expression of thioredoxin-interacting protein, and evidence of nitrosative stress in a rat model of Tako-Tsubo cardiomyopathy.. American Heart Association Scientific meeting. Dallas.
2013 Nguyen, T. (2013). Interaction Between Left and Right Ventricular Dysfunction in Tako-Tsubo Cardiomyopathy: Impact on Haemodynamics and Morbidity. the Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand. the Gold Coast.
2013 Horowitz, J., Nguyen, T., Neil, C., Singh, K., Chong, C., Licari, J. & Raman, B. (2013). Stress cardiomyopathy: new clinical and pathogenetic insights. 10th International Congress on Coronary Artery Disease (ICCAD). Florence, Italy.
10.1159/000355890
2013 Nguyen, T., Neil, C., Singh, K., Heresztyn, T., Chirkov, Y. & Horowitz, J. (2013). Determinants of prolonged impairment of global longitudinal strain post Takotsubo cardiomyopathy. European Society of Cardiology Congress 2013 (ESC 2013). Amsterdam, NETHERLANDS.
10.1093/eurheartj/eht309.P4247
2013 Nguyen, T. (2013). Can Recurrence of Takotsubo Cardiomyopathy be Predicted?. Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand. the Gold Coast.
2013 Nguyen, T. (2013). Not such a rarity: takotsubo cardiomyopathy as a mimic of ST elevation myocardial infarction.. the European Society of Cardiology. Amsterdam.
2012 Nguyen, T. H., Neil, A., Sverdlov, A., Ngo, D., Chan, W., Chirkov, Y. ... Horowitz, J. (2012). Paradoxical preservation of NO signalling in Takotsubo cardiomyopathy. Congress of the European-Society-of-Cardiology (ESC). Munchen, GERMANY.
2012 Nguyen, T. (2012). Residual LV Systolic Dysfunction Post-Tako-Tsubo Cardiomyopathy. the Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand. Brisbane.
2012 Nguyen, T. H. (2012). Takotsubo Cardiomyopathy is associated with “paradoxically” low ADMA concentrations. the ADMA meeting. London.
2012 Nguyen, T. (2012). Paradoxical preservation of NO signalling in Takotsubo cardiomyopathy.. the European Society of Cardiology. Munich.
2012 Nguyen, T. (2012). Cardiac denervation in chronic heart failure: relationship to changes in LV function and to arrhythmogenesis. the Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand. Brisbane.
2012 Nguyen, T. (2012). LV functional recovery from Tako-Tsubo cardiomyopathy is incomplete after 3 months: evidence from 2D speckle-tracking echocardiography.. the European Society of Cardiology. Munich.
2012 Neil, C., Nguyen, T., Mahadavan, G., Chapman, M., Kucia, A., Stansborough, J. ... Horowitz, J. (2012). LV functional recovery from Tako-Tsubo cardiomyopathy is incomplete after 3 months: evidence from 2D speckle-tracking echocardiography. Congress of the European-Society-of-Cardiology (ESC). Munchen, GERMANY.

 AUSiMED Foundation, Grant (2016): Limitation of myocardial injury by recently synthesised inhibitors of necrosis (total value A$240,000)

I have been a co-supervisor of 2 ongoing PhD students at the University of Adelaide. I also served as co-supervisor of 1 Master’s student (awarded 2016).

Memberships

Date Role Membership Country
2012 - ongoing Member Cardiac Society of Australia and New Zealand Australia
2011 - ongoing Member European Society of Cardiology
2010 - ongoing Member American Heart Association United States

Committee Memberships

Date Role Committee Institution Country
2015 - ongoing Member Scientific Review Subcommittee of the Human Research Ethics Committee (TQEH/LMH/MH) Australia

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