Tan Dai Nguyen

Tan Dai Nguyen

School of Biological Sciences

Faculty of Sciences, Engineering and Technology

Dr. Tan Dai Nguyen is an ARC-funded researcher with the Reproductive Success Group, led by Prof. Kylie Dunning, and the Centre of Light for Life under Prof. Kishan Dholakia. His work focuses on developing advanced biomedical devices, microfluidic systems, and surface acoustic waves for reproductive applications. He aims to leverage these technologies to create culture systems for long-term follicle and oocyte culture using sound waves, with the goal of advancing reproductive technologies and cell culture methods.

Dr. Nguyen earned his PhD in Mechanical Engineering from Nanyang Technological University, where he developed acoustic-based microfluidic devices for patterning and manipulating microparticles and cells on a chip, laying the foundation for tissue engineering and biostructure fabrication.

During his postdoctoral work at the Singapore-MIT Alliance for Research and Technology (SMART) - a partnership between MIT and Singapore's National Research Foundation - he led projects on high-throughput, label-free cell sorting and the detection of residual undifferentiated stem cells in progenitor cells, improving the quality control of stem cell-derived products. His research efforts resulted in two international patents. Before his current role, Dr. Nguyen was a scientist at the Agency for Science, Technology and Research (A*STAR), Bioprocessing Technology Institute (BTI) in Singapore, where he developed technologies for cell therapy manufacturing, optimizing production processes and cell culture environments to enhance the scalability of therapeutic cell production.

  • Journals
    Year Citation
    2024 Chen, S., Nguyen, T. D., Lee, K. -Z., & Liu, D. (2024). Ex vivo T cell differentiation in adoptive immunotherapy manufacturing: Critical process parameters and analytical technologies. Biotechnology Advances, 77, 108434.
    DOI
    2024 Nguyen, T. D., Chooi, W. H., Jeon, H., Chen, J., Tan, J., Roxby, D. N., . . . Han, J. (2024). Label-Free and High-Throughput Removal of Residual Undifferentiated Cells From iPSC-Derived Spinal Cord Progenitor Cells. Stem Cells Translational Medicine, 13(4), 387-398.
    DOI Scopus2 Europe PMC1
    2021 Nguyen, T. D., Tran, V. T., & Du, H. (2021). Manipulation of self-assembled three-dimensional architecture in reusable acoustofluidic device. Electrophoresis, 42(21-22), 2375-2382.
    DOI Scopus1
    2021 Nguyen, T. D., Tran, V. T., Pudasaini, S., Gautam, A., Lee, J. M., Fu, Y. Q., & Du, H. (2021). Large-Scale Fabrication of 3D Scaffold-Based Patterns of Microparticles and Breast Cancer Cells using Reusable Acoustofluidic Device. Advanced Engineering Materials, 23(6), 8 pages.
    DOI Scopus11
    2020 Nguyen, T. D., Fu, Y. Q., Tran, V. T., Gautam, A., Pudasaini, S., & Du, H. (2020). Acoustofluidic closed-loop control of microparticles and cells using standing surface acoustic waves. Sensors and Actuators, B: Chemical, 318, 9 pages.
    DOI Scopus30
    2019 Tao, X., Nguyen, T. D., Jin, H., Tao, R., Luo, J., Yang, X., . . . Fu, Y. Q. (2019). 3D patterning/manipulating microparticles and yeast cells using ZnO/Si thin film surface acoustic waves. Sensors and Actuators, B: Chemical, 299, 9 pages.
    DOI Scopus38
    2018 Nguyen, T. D., Tran, V. T., Fu, Y. Q., & Du, H. (2018). Patterning and manipulating microparticles into a three-dimensional matrix using standing surface acoustic waves. Applied Physics Letters, 112(21), 5 pages.
    DOI Scopus42

  • Conference Papers
    Year Citation
    2022 Nguyen, T. D., Chen, J., Liu, Q., Chew, S. Y., & Han, J. (2022). Label-free detection of residual undifferentiated iPSCs from their differentiated progenitor cells by microfluidic raman spectroscopy. In TISSUE ENGINEERING PART A Vol. 28 (pp. 567). SOUTH KOREA, Jeju: MARY ANN LIEBERT, INC.
    2022 Roxby, D., Chen, J., Yao, J. T. Z., Nguyen, T. D., Chew, S. Y., & Han, J. (2022). Magnetic resonance relaxometry as a tool for tracking induced pluripotent stem cell variability. In TISSUE ENGINEERING PART A Vol. 28 (pp. 563). SOUTH KOREA, Jeju: MARY ANN LIEBERT, INC.

  • Preprint
    Year Citation
    2022 Nguyen, T. D., Chooi, W. H., Jeon, H., Chen, J., Roxby, D. N., Zu Yao, J. T., . . . Han, J. (2022). Label-free and high-throughput removal of residual undifferentiated cells from iPSC-derived spinal-cord progenitor cells.
    DOI

Career Development Fund - Pitchfest for Early Career Researchers, Agency for Science, Technology and Research (A*STAR), Singapore, $70,000 SGD

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