Dr Tamsin Lannagan
Postdoctoral Researcher
South Australian Immunogenomics Cancer Institute
Faculty of Health and Medical Sciences
Senior Postdoctoral Researcher in T Cell Immunotherapy Laboratory (SAiGENCI).
Dr Lannagan completed her PhD at the University of Edinburgh in Scotland in 2009 and has spent the last 13 years working with mouse models of cancer in Australia at CSIRO and SAHMRI (with Dan Worthley and Susan Woods) and in Scotland at the CRUK Scotland Institute (with Owen Sansom). Her areas of expertise have been in characterising KRAS genetically engineered mouse models (GEMMS) of early and metastatic colorectal cancer using sequencing technologies, looking at the tumour microenvironment as well as investigating stem cell plasticity. She has used complex GEMMS, generated in vitro tumour organoids and has used these to develop surgical and transplant models of metastatic cancer. These models were aligned to patient disease subtypes and she ran trials using mouse cancer models to test novel therapeutics. Dr Lannagan returned to Adelaide in 2024 to work under Dr Mara Zeissig in the T Cell Immunotherapy Lab at SAiGENCI.
Dr Lannagan is working on improving responses to T-cell based immunotherapies in solid cancers, with a focus on lung and pancreatic cancers. The lab uses a range of approaches, including genetically engineered mouse models and sophisticated CRISPR-Cas9 genetic screening techniques to understand how tumours evade the immune system and identify immune modulators to increase the efficacy of immunotherapy in solid tumours.
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Appointments
Date Position Institution name 2024 - ongoing Senior Postdoctoral Researcher University of Adelaide 2021 - 2024 Principal Scientific Officer Cancer Research UK Beatson Institute 2019 - 2021 Postdoctoral Researcher Cancer Research UK Beatson Institute 2015 - 2018 Postdoctoral Researcher University of Adelaide 2011 - 2014 Office of the Chief Executive Postdoctoral Fellow Commonwealth Scientific and Industrial Research Organisation 2009 - 2011 Career Development Fellow Medical Research Council -
Education
Date Institution name Country Title 2004 - 2009 University of Edinburgh United Kingdom PhD 1999 - 2003 University of Edinburgh United Kingdom BSc -
Research Interests
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Journals
Year Citation 2025 Mzoughi, S., Schwarz, M., Wang, X., Demircioglu, D., Ulukaya, G., Mohammed, K., . . . Guccione, E. (2025). Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer. Nature Genetics, 57(2), 402-412.
Europe PMC12025 Torang, A., Kirov, A. B., Lammers, V., Cameron, K., Wouters, V. M., Jackstadt, R. F., . . . Medema, J. P. (2025). Enterocyte-like differentiation defines metabolic gene signatures of CMS3 colorectal cancers and provides therapeutic vulnerability. Nature Communications, 16(1), 16 pages.
Europe PMC12024 Fetit, R., McLaren, A. S., White, M., Mills, M. L., Falconer, J., Cortes-Lavaud, X., . . . Steele, C. W. (2024). Characterizing Neutrophil Subtypes in Cancer Using scRNA Sequencing Demonstrates the Importance of IL1β/CXCR2 Axis in Generation of Metastasis-specific Neutrophils. Cancer research communications, 4(2), 588-606.
Scopus1 Europe PMC12024 Loi, P., Schade, A. E., Rodriguez, C. L., Krishnan, A., Perurena, N., Nguyen, V. T. M., . . . Cichowski, K. (2024). Epigenetic and Oncogenic Inhibitors Cooperatively Drive Differentiation and Kill KRAS-Mutant Colorectal Cancers. Cancer Discovery, 14(12), 2430-2449.
Europe PMC12024 Malviya, G., Lannagan, T., Johnson, E., Mackintosh, A., Bielik, R., Peters, A., . . . Lewis, D. (2024). Noninvasive Stratification of Colon Cancer by Multiplex PET Imaging. CLINICAL CANCER RESEARCH, 30(8), 1518-1529.
2024 Gurbatri, C. R., Radford, G. A., Vrbanac, L., Im, J., Thomas, E. M., Coker, C., . . . Danino, T. (2024). Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia. Nature Communications, 15(1), 646-1-646-13.
Scopus39 Europe PMC282024 Malla, S. B., Byrne, R. M., Lafarge, M. W., Corry, S. M., Fisher, N. C., Tsantoulis, P. K., . . . Dunne, P. D. (2024). Correction to: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer (Nature Genetics, (2024), 56, 3, (458-472), 10.1038/s41588-024-01654-5). Nature Genetics, 56(6), 1321.
Scopus12024 Malviya, G., Lannagan, T. R. M., Johnson, E., Mackintosh, A., Bielik, R., Peters, A., . . . Lewis, D. Y. (2024). Noninvasive Stratification of Colon Cancer by Multiplex PET Imaging. Clinical Cancer Research, 30(8), 1518-1529.
2024 Nair, R., Lannagan, T. R. M., Jackstadt, R., Andrusaite, A., Cole, J., Boyne, C., . . . Milling, S. (2024). Co-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance. OncoImmunology, 13(1).
Scopus22024 Pennel, K. A. F., Hatthakarnkul, P., Wood, C. S., Lian, G. Y., Al-Badran, S. S. F., Quinn, J. A., . . . Edwards, J. (2024). JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43(1).
Scopus132024 Malla, S. B., Byrne, R. M., Lafarge, M. W., Corry, S. M., Fisher, N. C., Tsantoulis, P. K., . . . Dunne, P. D. (2024). Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56(3), 458-472.
Scopus162023 Vande Voorde, J., Steven, R. T., Najumudeen, A. K., Ford, C. A., Dexter, A., Gonzalez-Fernandez, A., . . . Sansom, O. J. (2023). Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature Metabolism, 5(8), 1303-1318.
Scopus212023 Amirkhah, R., Gilroy, K., Malla, S. B., Lannagan, T. R. M., Byrne, R. M., Fisher, N. C., . . . Dunne, P. D. (2023). MmCMS: mouse models’ consensus molecular subtypes of colorectal cancer. British Journal of Cancer, 128(7), 1333-1343.
Scopus102023 Ng, J. Q., Jafarov, T. H., Little, C. B., Wang, T., Ali, A. M., Ma, Y., . . . Mukherjee, S. (2023). Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis. Nature Communications, 14(1), 6909-1-6909-14.
Scopus10 Europe PMC132022 Kobayashi, H., Gieniec, K. A., Lannagan, T. R., Wang, T., Asai, N., Mizutani, Y., . . . Worthley, D. L. (2022). The origin and contribution of cancer-associated fibroblasts in colorectal carcinogenesis. Gastroenterology, 162(3), 890-906.
Scopus113 WoS37 Europe PMC992022 Gil Vazquez, E., Nasreddin, N., Valbuena, G. N., Mulholland, E. J., Belnoue-Davis, H. L., Eggington, H. R., . . . Leedham, S. J. (2022). Erratum: Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia (Cell Stem Cell (2022) 29(8) (1213–1228.e8), (S1934590922003034), (10.1016/j.stem.2022.07.008)). Cell Stem Cell, 29(11), 1612.
Scopus32022 Freckmann, E. C., Sandilands, E., Cumming, E., Neilson, M., Román-Fernández, A., Nikolatou, K., . . . Bryant, D. M. (2022). Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13(1).
Scopus132022 Vasquez, E. G., Nasreddin, N., Valbuena, G. N., Mulholland, E. J., Belnoue-Davis, H. L., Eggington, H. R., . . . Leedham, S. J. (2022). Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia. Cell Stem Cell, 29(8), 1213-1228.e8.
Scopus47 Europe PMC472022 Corry, S. M., Mccorry, A. M. B., Lannagan, T. R. M., Leonard, N. A., Fisher, N. C., Byrne, R. M., . . . Dunne, P. D. (2022). Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer. Gut, 71(12), 2502-2517.
Scopus112022 Ahmaderaghi, B., Amirkhah, R., Jackson, J., Lannagan, T. R. M., Gilroy, K., Malla, S. B., . . . Dunne, P. D. (2022). Molecular Subtyping Resource: a user-friendly tool for rapid biological discovery from transcriptional data. DMM Disease Models and Mechanisms, 15(3).
Scopus32021 Gillespie, M. A., Steele, C. W., Lannagan, T. R. M., Sansom, O. J., & Roxburgh, C. S. D. (2021). Pre-clinical modelling of rectal cancer to develop novel radiotherapy-based treatment strategies. Oncology Reviews, 15(1), 8 pages.
Scopus5 Europe PMC32021 Krotenberg Garcia, A., Fumagalli, A., Le, H. Q., Jackstadt, R., Lannagan, T. R. M., Sansom, O. J., . . . Suijkerbuijk, S. J. E. (2021). Active elimination of intestinal cells drives oncogenic growth in organoids. Cell Reports, 36(1), 18 pages.
Scopus232021 Ramesh, P., Lannagan, T. R. M., Jackstadt, R., Atencia Taboada, L., Lansu, N., Wirapati, P., . . . Medema, J. P. (2021). BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer. Cell Death and Differentiation, 28(12), 3282-3296.
Scopus362021 Lannagan, T. R., Jackstadt, R., Leedham, S. J., & Sansom, O. J. (2021). Advances in colon cancer research: in vitro and animal models. Current Opinion in Genetics and Development, 66, 50-56.
Scopus512021 Ichinose, M., Suzuki, N., Wang, T., Wright, J. A., Lannagan, T. R. M., Vrbanac, L., . . . Woods, S. L. (2021). Delineating proinflammatory microenvironmental signals by ex vivo modeling of the immature intestinal stroma. Scientific Reports, 11(1), 7200-1-7200-11.
Scopus1 WoS1 Europe PMC12021 Suzuki, M., Suzuki, N., Wang, T., Kobayashi, H., Vrbanac, L., Ng, J. Q., . . . Woods, S. L. (2021). The BMP antagonist Gremlin1 contributes to the development of cortical excitatory neurons, motor balance and fear responses. Development, 148(14), dev195883-1-dev195883-15.
Scopus7 WoS4 Europe PMC62021 Kobayashi, H., Gieniec, K. A., Ng, J. Q., Goyne, J., Lannagan, T. R. M., Thomas, E. M., . . . Woods, S. L. (2021). Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma. Journal of Visualized Experiments, 2021(175), e62630-1-e62630-21.
Scopus1 Europe PMC12021 Suzuki, M. I., Suzuki, N., Wang, T., Wright, J. A., Lannagan, T. R., Vrbanac, L., . . . Woods, S. L. (2021). Stromal DLK1 promotes proliferation and inhibits differentiation of the intestinal epithelium during development. American Journal of Physiology: Gastrointestinal and Liver Physiology, 320(4), G506-G520.
Scopus5 WoS3 Europe PMC32020 Narasimhan, V., Wright, J. A., Churchill, M., Wang, T., Rosati, R., Lannagan, T. R., . . . Woods, S. L. (2020). Medium-throughput drug screening of patient-derived organoids from colorectal peritoneal metastases to direct personalized therapy. Clinical Cancer Research, 26(14), 1-26.
Scopus138 WoS79 Europe PMC1062020 Kobayashi, H., Gieniec, K. A., Wright, J. A., Wang, T., Asai, N., Mizutani, Y., . . . Woods, S. L. (2020). The Balance of stromal BMP signaling mediated by GREM1 and ISLR drives colorectal carcinogenesis. Gastroenterology, 160(4), 1224-1239.
Scopus95 WoS60 Europe PMC822019 Lannagan, T. R. M., Lee, Y. K., Wang, T., Roper, J., Bettington, M. L., Fennell, L., . . . Woods, S. L. (2019). Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis. Gut, 68(4), 684-692.
Scopus90 WoS63 Europe PMC762019 Kleeman, S. O., Koelzer, V. H., Jones, H. J., Vazquez, E. G., Davis, H., East, J. E., . . . Leedham, S. J. (2019). Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification. Gut, 69(6), 1092-1103.
Scopus54 WoS42 Europe PMC472018 Bond, C., Liu, C., Kawamata, F., McKeone, D., Fernando, W., Jamieson, S., . . . Whitehall, V. (2018). Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia. Epigenetics, 13(1), 40-48.
Scopus49 WoS37 Europe PMC352017 Lannagan, T., Lee, Y., Somashekar, R., Wang, T., Vrbanac, L., Ng, J., . . . Woods, S. (2017). GENETIC EDITING OF COLONIC ORGANOIDS PROVIDES A MOLECULARLY DISTINCT AND ORTHOTOPIC MOUSE MODEL OF SERRATED CARCINOGENESIS. GASTROENTEROLOGY, 152(5), S103.
2016 Li, J., Woods, S., Healey, S., Beesley, J., Chen, X., Lee, J., . . . Schrader, K. (2016). Point mutations in Exon 1B of APC reveal gastric adenocarcinoma and proximal polyposis of the stomach as a familial adenomatous polyposis variant. American Journal of Human Genetics, 98(5), 830-842.
Scopus187 WoS122 Europe PMC1032016 Le Leu, R., Scherer, B., Mano, M., Winter, J., Lannagan, T., Head, R., . . . Clarke, J. (2016). Dietary butyrylated high-amylose starch reduces azoxymethane-induced colonic O⁶ -methylguanine adducts in rats as measured by immunohistochemistry and high-pressure liquid chromatography. Nutrition Research, 36(9), 982-988.
Scopus9 WoS6 Europe PMC62013 Lannagan, T., Wilson, M., Denison, F., Norman, J., Catalano, R., & Jabbour, H. (2013). Prokineticin 1 induces a pro-inflammatory response in murine fetal membranes but does not induce preterm delivery. Reproduction, 146(6), 581-591.
Scopus5 WoS3 Europe PMC42010 Catalano, R. D., Lannagan, T. R. M., Gorowiec, M., Denison, F. C., Norman, J. E., & Jabbour, H. N. (2010). Prokineticins: novel mediators of inflammatory and contractile pathways at parturition?. Molecular Human Reproduction, 16(5), 311-319.
Scopus33 Europe PMC232009 Filis, P., Lannagan, T., Thomson, A., Murray, A. A., Kind, P. C., & Spears, N. (2009). Phospholipase C-β1 signaling affects reproductive behavior, ovulation, and implantation. Endocrinology, 150(7), 3259-3266.
Scopus7 Europe PMC4- Kobayashi, H., Gieniec, K. A., Ng, J. Q., Goyne, J., Lannagan, T. R. M., Thomas, E. M., . . . Woods, S. L. (n.d.). Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma. Journal of Visualized Experiments, (175).
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Conference Papers
Year Citation 2024 Melissourgou-Syka, L., Gillespie, M. A., Stevenson, K., Lannagan, T. R. M., O'Cathail, S. M., Steele, C. W., . . . Roxburgh, C. S. D. (2024). The Role of the Tumour Niche on Radiation Response in a Murine Model of Rectal Cancer. In RADIOTHERAPY AND ONCOLOGY Vol. 194 (pp. S5341-S5342). ENGLAND, Glasgow: ELSEVIER IRELAND LTD. 2020 Kobayashi, H., Gieniec, K., Lannagan, T., Wang, T., Asfaha, S., Hayakawa, Y., . . . Worthley, D. (2020). THE ORIGIN AND FUNCTION OF CANCER-ASSOCIATED FIBROBLASTS IN COLORECTAL CARCINOGENESIS. In GASTROENTEROLOGY Vol. 158 (pp. S160). TX, Austin: W B SAUNDERS CO-ELSEVIER INC. 2020 Suzuki, N., Wright, J., Kobayashi, H., Wang, T., Ichinose, M., Vrbanac, L., . . . Worthley, D. (2020). GENERATION OF A GASTRIC ADENOCARCINOMA AND PROXIMAL POLYPOSIS OF THE STOMACH (GAPPS) MOUSE THAT PHENOCOPIES HUMAN DISEASE. In GASTROENTEROLOGY Vol. 158 (pp. S160). TX, Austin: W B SAUNDERS CO-ELSEVIER INC. 2020 Ichinose, M., Suzuki, N., Wang, T., Wright, J., Vrbanac, L., Lannagan, T., . . . Worthley, D. (2020). STROMAL DLK1 PROMOTES EPITHELIAL PROLIFERATION AND INHIBITS DIFFERENTIATION IN SMALL INTESTINE DEVELOPMENT. In GASTROENTEROLOGY Vol. 158 (pp. S87). Austin, TX: W B SAUNDERS CO-ELSEVIER INC. 2017 Whitehall, V., Bond, C., Liu, C., Kawamata, F., McKeone, D., Jamieson, S., . . . Leggett, B. (2017). Oncogenic <i>BRAF</i> mutation induces widespread DNA hypermethylation in a murine model for human serrated colorectal neoplasia. In CANCER RESEARCH Vol. 77 (pp. 2 pages). DC, Washington: AMER ASSOC CANCER RESEARCH.
DOI2016 Lannagan, T., Woods, S., Vrbanac, L., Yang, M., Ng, J., Wang, T., . . . Worthley, D. L. (2016). Desmoplasia stem and progenitor cells within the tumor microenvironment. In CANCER RESEARCH Vol. 76 (pp. 3 pages). LA, New Orleans: AMER ASSOC CANCER RESEARCH.
DOI2016 Lannagan, T. R. M., Mano, M. T., Head, R. J., Lockett, T., Ernst, M., & Cosgrove, L. J. (2016). DNA damage and tumour burden in mouse colon is increased in response to carcinogen exposure after induction of chronic inflammation - a more disease relevant model of colitis-associated colorectal cancer. In CANCER RESEARCH Vol. 76 (pp. 3 pages). New Orleans, LA: AMER ASSOC CANCER RESEARCH.
DOI WoS12011 Lannagan, T. R. M., Wilson, M. R., Battersby, S., Denison, F. C., Norman, J. E., Bennett, P. R., . . . Jabbour, H. N. (2011). The Mouse and the Membranes: A Role for Prokineticins in Infection-Induced Preterm Labor. In REPRODUCTIVE SCIENCES Vol. 18 (pp. 265A). SAGE PUBLICATIONS INC. 2007 Lannagan, T., Price, D., & Spears, N. (2007). Immune-like response in the developing mouse ovary.. In BIOLOGY OF REPRODUCTION (pp. 123). TX, San Antonio: SOC STUDY REPRODUCTION. 2004 Murray, A., Lannagan, T., Kind, P., & Spears, N. (2004). Investigation of the effect of PLC-β1 in mouse reproduction. In BIOLOGY OF REPRODUCTION (pp. 146). CANADA, Univ British Columbia, Vancouver: SOC STUDY REPRODUCTION. -
Conference Items
Year Citation 2017 Woods, S. L., Lannagan, T. R. M., Suzuki, N., Yang, M., Lee, Y. K., Wang, T., . . . Worthley, D. L. (2017). Bridging the GAPP between the laboratory and clinic to prevent gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). Poster session presented at the meeting of JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. WILEY. 2017 Lannagan, T. R. M., Woods, S. L., Wang, T., Somashekar, R., Yang, M., Ng, J. Q., . . . Worthley, D. L. (2017). Gremlin 1-expressing intestinal reticular stem cells give rise to cancer-associated fibroblasts in a mouse model of colorectal cancer. Poster session presented at the meeting of JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. WILEY. 2017 Lannagan, T. R. M., Lee, Y. K., Gieniec, K., Wang, T., Somashekar, R., Yang, M., . . . Woods, S. L. (2017). The development of a state-of the art, high-sensitivity stool DNA test to improve screening for serrated polyps and early lesions. Poster session presented at the meeting of JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. WILEY.
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Committee Memberships
Date Role Committee Institution Country 2025 - ongoing Member SAiGENCI Postdoctoral Committee SAiGENCI Australia
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