Dr Sue Heatley
Project Manager
School of Public Health
College of Health
Dr Sue Heatley Environmental Change & Health OutcomesSchool of Public HealthPrevious:Postdoctoral Research Fellow, South Australian Health & Medical Research InstituteThe Kids Cancer Project Postdoctoral Fellow (2016-2022)Centre for Cancer Biology, Australian Red Cross Blood Service, St Jude Children's Research Hospital Education:University of Melbourne Experience:Post-doctoral FellowSouth Australian Health & Medical Research InstituteJuly 2013 - March 2025Genomics Research Team LeaderSouth Australian Health & Medical Research InstituteJuly 2013 – Dec 2016|AdelaidePostdoctoral ScientistCentre for Cancer BiologyAugust 2011 – June 2013 (1 year 11 months)|AdelaideMedical Education Project OfficerAustralian Red Cross Blood ServiceJuly 2009 – August 2011 (2 years 2 months)|AdelaideVisiting Postdoctoral FellowSt Jude Children's Research HospitalJune 2010 – February 2011 (9 months)|Memphis, TN, USAMedical Scientist, Research & DevelopmentAustralian Red Cross Blood ServiceJanuary 1998 – June 2009 (11 years 6 months)|AdelaideMedical Scientist/Technical Officer/Nurse attendantAustralian Red Cross Blood ServiceOctober 1984 – December 1997 (13 years 3 months)|Adelaide
Dr Sue Heatley gained her PhD in Transplant Immunology from the University of Melbourne in 2011. She also has a Masters in Education (Educational Leadership). In 2010 she was awarded a New Investigator Scholarship by the Haematology Society of Australia & New Zealand (HSANZ) to undertake a visiting fellow position in the laboratory of Prof Charles Mullighan at the St Jude’s Children’s Research Hospital, Memphis, TN, USA. In 2013, Sue accepted her current position at SAHMRI in the Leukaemia Research group of Prof Deb White and Prof Tim Hughes in the Cancer Theme. She is a member of several professional societies including HSANZ and the Australian & New Zealand Children’s Haematology and Oncology Group.
Sue has extensive laboratory experience having worked at the Australian Red Cross Blood Service for over 25 years including over 12 years in the Research Department and 2 years in Medical Education. She has presented her research at both national and international meetings, being awarded the prestigious Albert Baikie Memorial Medal in 2015 for best presentation by a new investigator. Sue has authored over 30 publications with over 3000 career citations and is the current Kids Cancer Project Postdoctoral Fellow. Her current research interests are focussed on the genomic landscape of ALL and improving patient outcome through personalised medicine.
| Date | Position | Institution name |
|---|---|---|
| 2025 - ongoing | Project Manager | University of Adelaide |
| 2013 - ongoing | Affiliate Senior Lecturer | University of Adelaide |
| Date | Type | Title | Institution Name | Country | Amount |
|---|---|---|---|---|---|
| 2016 | Award | HSANZ Travel Award | Haematology Society of Australia and New Zealand | Australia | $1000 |
| 2016 | Fellowship | The Kids Cancer Project Postdoctoral Fellow | - | Australia | $170,932 |
| 2015 | Award | Albert Baikie Memorial Award | Haematology Society of Australia and New Zealand | Australia | $3000 |
| 2009 | Award | ASHI International Scholar | American Society for Histocompatability and Immunogenetics | United States | - |
| 2009 | Achievement | Presidential Symposium | Haematology Society of Australia and New Zealand | Australia | - |
| 2009 | Scholarship | New Investigator Scholarship | Haematology Society of Australia and New Zealand | Australia | $30,000 |
| Date | Institution name | Country | Title |
|---|---|---|---|
| 2011 - 2012 | Charles Sturt University | Australia | Master of Education |
| 2004 - 2011 | University of Melbourne | Australia | PhD |
| 2002 - 2004 | Charles Sturt University | Australia | Bachelor of Medical Science (Honours) |
| 1996 - 1999 | Charles Sturt University | Australia | Bachelor of Medical Science (Pathology) |
| Date | Title | Institution | Country |
|---|---|---|---|
| 2010 - 2011 | Visting Postdoctoral Fellow | St Jude Children's Research Hospital | United States |
| Year | Citation |
|---|---|
| 2020 | Tavakoli, P. S., Eadie, L., Heatley, S. L., Yeung, D. T., & White, D. L. (2020). The MYB-TYK2 gene fusion induces B-cell acute lymphoblastic leukaemia in in vitro and in vivo models and can be effectively targeted by the dual SYK/JAK inhibitor, cerdulatinib (Vol. 4). Lippincott, Williams & Wilkins. DOI |
| Year | Citation |
|---|---|
| 2023 | White, D. L., Rehn, J. A., Schutz, C. E., Heatley, S. L., Eadie, L. N., Thomson, A., . . . Greenwood, M. (2023). Improved MRD Negativity Rates in Adverse Genomic Risk B-ALL Patients with Chemotherapy / Blinatumomab Induction: Experience from the Australasian Leukaemia Lymphoma Group (ALLG) ALL06/09 Studies. In BLOOD Vol. 142 (pp. 6 pages). CA, San Diego: AMER SOC HEMATOLOGY. DOI |
| 2023 | Eadie, L. N., Schutz, C. E., Page, E. C., Conlin, T. S., Heatley, S. L., Lagonik, E., . . . White, D. L. (2023). Asciminib Is Effective Against ABL1 Gene Fusions in Acute Lymphoblastic Leukemia but Only When the ABL1 SH3 Domain Is Present. In BLOOD Vol. 142 (pp. 4 pages). CA, San Diego: AMER SOC HEMATOLOGY. DOI WoS4 |
| 2021 | Page, E. C., Heatley, S. L., Rehn, J., Yeung, D. T., Thomas, P. Q., & White, D. L. (2021). <i>HMGN1</i> expression Predisposes Down Syndrome Patients to Develop <i>P2RY8-CRLF2</i> acute Lymphoblastic Leukemia. In BLOOD Vol. 138 (pp. 4 pages). GA, Atlanta: ELSEVIER. DOI |
| 2019 | Dean, M. M., Lopez, G. H., Liley, H. G., Heatley, S. L., & Minchinton, R. M. (2019). Development of functional mannose binding lectin is delayed in extremely low birth weight infants. In JOURNAL OF IMMUNOLOGY Vol. 202 (pp. 3 pages). San Diego, CA: AMER ASSOC IMMUNOLOGISTS. |
| 2016 | Asari, K., Heatley, S. L., Sadras, T., Leclercq, T. M., Fitter, S., Kok, C. H., . . . White, D. L. (2016). <i>In Vitro</i> Modeling of Ph-like ALL Fusions Identifies Novel Kinase-Domain Mutations As Mode of TKI-Resistance Implications for Targeted Therapy. In BLOOD Vol. 128 (pp. 5 pages). San Diego, CA: AMER SOC HEMATOLOGY. DOI WoS1 |
| 2016 | Pagani, I. S., Kok, C. H., Saunders, V., Goyne, J., McLean, J., VanderHoek, M., . . . Ross, D. M. (2016). The genomic landscape of mitochondrial DNA mutations in chronic myeloid leukaemia.. In European Journal of Human Genetics. Barcelona: Natue Publishing Group. |
| 2016 | Pagani, I. S., Kok, C. H., Wang, J., Saunders, V., Goyne, J., McLean, J., . . . Ross, D. M. (2016). MITOCHONDRIAL DNA MUTATIONS IDENTIFY CLONAL HETEROGENEITY IN CHRONIC MYELOID LEUKAEMIA. In HAEMATOLOGICA Vol. 101 (pp. 234). Copenhagen, DENMARK: FERRATA STORTI FOUNDATION. |
| 2016 | Zaliova, M., Moorman, A. V., Cazzaniga, G., Stanulla, M., Harvey, R. C., Roberts, K. G., . . . Zuna, J. (2016). Characterization of leukemias with ETV6-ABL1 fusion. In Proceedings of the 57th Annual Meeting of the American-Society-of-Hematology, as published in Haematologica Vol. 101 (pp. 1082-1093). Orlando, FL: Ferrata Storti Foundation. DOI Scopus81 WoS74 Europe PMC65 |
| 2015 | Hiwase, D., Hahn, C., Babic, M., Moore, S., Singhal, D., Kutyna, M., . . . Scott, H. (2015). MULTIPLE MUTATIONS IN THE SAME GENE SUGGEST CLONAL DIVERSITY AND IS ASSOCIATED WITH POOR PROGNOSIS IN MDS. In LEUKEMIA RESEARCH Vol. 39 (pp. S77-S78). Washington, DC: PERGAMON-ELSEVIER SCIENCE LTD. DOI |
| 2011 | Zhang, J., Ding, L., Holmfeldt, L., Wu, G., Heatley, S. L., Payne-Turner, D., . . . Mullighan, C. G. (2011). Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project. In BLOOD Vol. 118 (pp. 32-33). San Diego, CA: AMER SOC HEMATOLOGY. |
| 2010 | Mullighan, C., Zhang, J., Kasper, L. H., Lerach, S., Payne-Turner, D., Phillips, L. A., . . . Downing, J. R. (2010). <i>CREBBP</i> Mutations In Relapsed Acute Lymphoblastic Leukemia. In BLOOD Vol. 116 (pp. 184). Orlando, FL: AMER SOC HEMATOLOGY. WoS1 |
| 2010 | Heatley, S. L., Mullighan, C. G., Sullivan, L. C., Brooks, A. G., Szer, J., Bradstock, K., . . . Bardy, P. G. (2010). KIR HAPLOTYPE MAY INFLUENCE CLINICAL OUTCOME FOLLOWING HLA-MATCHED SIBLING HAEMOPOIETIC STEM CELL TRANSPLANTATION. In BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION Vol. 16 (pp. S270). ELSEVIER SCIENCE INC. DOI |
| 2009 | Heatley, S., Sullivan, L., Pietra, G., Lin, J., Jordan, J., Mingari, M. C., . . . Brooks, A. (2009). RECOGNITION OF HLA-E BY NATURAL KILLER CELLS IS IMPACTED BY VARIATION IN CYTOMEGALOVIRUS UL40 SEQUENCES IN HAEMOPOIETIC STEM CELL TRANSPLANTATION. In HUMAN IMMUNOLOGY Vol. 70 (pp. S167). CA, San Francisco: ELSEVIER SCIENCE INC. DOI |
| 2009 | Heatley, S., Mullighan, C., Sullivan, L., Brooks, A., & Bardy, P. (2009). THE EFFECT OF KIR HAPLOTYPE ON CLINICAL OUTCOME FOLLOWING HLA-MATCHED SIBLING HAEMOPOIETIC STEM CELL TRANSPLANTATION. In HUMAN IMMUNOLOGY Vol. 70 (pp. S169). San Francisco, CA: ELSEVIER SCIENCE INC. DOI |
| 2007 | Hurst, N., Mullighan, C. G., Heatley, S. L., Robinson, K., Danner, S., Hahn, U., . . . Bardy, P. G. (2007). Risk factors for blood product usage following sibling allogeneic haemopoietic stem cell transplantation (allo-HCT). In BLOOD Vol. 110 (pp. 856A). Atlanta, GA: AMER SOC HEMATOLOGY. DOI |
| 2007 | Worthley, D. L., Mullighan, C. G., Dean, M. M., Gordon, D. L., Phillips, P., Heatley, S., . . . Bardy, P. G. (2007). Mannose-binding lectin deficiency does not predispose to <i>Helicobacter pylori</i> infection. In GASTROENTEROLOGY Vol. 132 (pp. A709). DC, Washington: W B SAUNDERS CO-ELSEVIER INC. |
| 2006 | Mullighan, C., Heatley, S. L., Villalta, N. R., Doherty, K. V., Danner, S., Hahn, U., . . . Bardy, P. G. (2006). Extended <i>TNF</i> genotyping identifies <i>TNF</i>-857T as a risk factor for acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.. In BLOOD Vol. 108 (pp. 16A). Orlando, FL: AMER SOC HEMATOLOGY. DOI |
| 2006 | Mullighan, C. G., Heatley, S. E., Danner, S., Dean, M., Doherty, K. V., Hahn, U., . . . Bardy, P. G. (2006). Mannose-binding lectin status is associated with risk of major infection following myeloalblative sibling allogeneic hematopoietic stem cell transplantation.. In BLOOD Vol. 108 (pp. 829A). Orlando, FL: AMER SOC HEMATOLOGY. DOI |
| 2003 | Eisen, D., Dean, M., Heatley, S., O'Sullivan, M., & Minchinton, R. (2003). Mannose binding lectin insufficiency predisposes to cryptococcal infection in HIV negative patients. In TRENDS IN MEDICAL MYCOLOGY (pp. 17-20). NETHERLANDS, AMSTERDAM: MEDIMOND S R L. |
| 2002 | Heatley, S., Humphreys, I., & Doherty, K. (2002). Polymorphisms in <i>HFE</i> and <i>DMT1</i>:: Their frequency and effect on iron stores in blood donors.. In TRANSFUSION Vol. 42 (pp. 69S-70S). FLORIDA, ORLANDO: AMER ASSOC BLOOD BANKS. |
| 2000 | Bardy, P., Grigg, A. P., Szer, J., Roberts, A., Schwarer, A. P., Spencer, A., . . . Hughes, T. P. (2000). Successful engraftment with disease response following sibling allograft with reduced conditioning, T-cell depletion and delayed incremental DLI in CML and MM.. In BLOOD Vol. 96 (pp. 783A). AMER SOC HEMATOLOGY. |
| Year | Citation |
|---|---|
| 2024 | Rehn, J., Heatley, S., Page, E., Eadie, L., Schutz, C., Thomson, A., . . . White, D. (2024). Acquired copy number variants are highly correlated with Ph+ALL subgroups identified by transcriptomic analysis. Poster session presented at the meeting of Blood Annual Scientific Meeting. |
| 2024 | Rehn, J., Page, E., Heatley, S., Eadie, L., Schutz, C., Thomson, A., . . . White, D. (2024). Genomic characterisation of PAX5alt B-cell acute lymphoblastic leukaemia reveals novel PAX5 fusions. Poster session presented at the meeting of Australian and New Zealand Children’s Haematology/Oncology Group (ANZCHOG) Scientific Meeting. |
| 2023 | Rehn, J., Schutz, C., Page, E., Heatley, S., Eadie, L., McClure, B., . . . White, D. (2023). High expression of DUX4 mRNA is a reliable indicator of DUX4-rearranged acute lymphoblastic leukaemia. Poster session presented at the meeting of Australian and New Zealand Children’s Haematology/Oncology group (ANZCHOG) Scientific Meeting. |
| 2022 | Thomson, A., Rehn, J., Heatley, S., Eadie, L., McClure, B., Page, E., . . . White, D. (2022). Benchmarking the detection rate of IGH gene fusions in B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Australian Bioinformatics and Computational Biology Society (ABACBS) Conference. |
| 2021 | Heatley, S. L., Page, E. C., Eadie, L. N., McClure, B. J., Rehn, J., Yeung, D. T., . . . White, D. L. (2021). Modeling Relapsed, Refractory Acute Lymphoblastic Leukemia from a Child with Neurofibromatosis. Poster session presented at the meeting of BLOOD. GA, Atlanta: AMER SOC HEMATOLOGY. DOI WoS1 |
| 2021 | Eadie, L., Heatley, S., McClure, B., Rehn, J., Schutz, C., Breen, J., . . . White, D. (2021). Next Generation Genomic Analyses Inform Druggable Targets In T-All Patients. Poster session presented at the meeting of 4th International T-ALL/T-NHL conference: T-ALL2020: Omics, genetics and therapy. |
| 2021 | McClure, B., Heatley, S., Grose, R., & White, D. (2021). Activation of the immune cell repertoire in B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of 12th Biennial Childhood Leukemia and Lymphoma Symposium (CLLS). |
| 2021 | Eadie, L., Heatley, S., McClure, B., Rehn, J., Schutz, C., Breen, J., . . . White, D. (2021). Next Generation Genomic Analyses Inform Druggable Targets In T-All Patients. Poster session presented at the meeting of 12th Biennial Childhood Leukemia and Lymphoma Symposium (CLLS). |
| 2021 | Heatley, S., Rehn, J., Breen, J., Moore, A., Sutton, R., Osborn, M., & White, D. (2021). Using single cell mRNAseq to interrogate the genomic consequences of Ph-like acute lymphoblastic leukaemia in adolescents. Poster session presented at the meeting of 12th Biennial Childhood Leukemia and Lymphoma Symposium (CLLS). |
| 2020 | Page, E., Heatley, S., Thomas, P., & White, D. (2020). HMGN1 is necessary for Down Syndrome leukaemic cell proliferation and cooperates with CRLF2 for leukaemic transformation. Poster session presented at the meeting of The 59th ASMR National Scientific Conference. |
| 2020 | Eadie, L. N., Rehn, J., Heatley, S. L., McClure, B. J., Schutz, C. S., Breen, J., . . . White, D. L. (2020). Next Generation Genomic Analyses in T-ALL Patients Identify Recurrent and Novel Genomic Abnormalities. Poster session presented at the meeting of BLOOD. ELECTR NETWORK: ELSEVIER. DOI WoS1 |
| 2020 | Tavakoli, P., Eadie, L. N., Heatley, S. L., Bruning, J. B., & White, D. L. (2020). Persistent Activation of JAK/STAT Signaling Plays an Important Role in<i>in Vitro</i>Jaki Resistance in <i>TYK2</i>-rearranged B-Cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of BLOOD. ELECTR NETWORK: ELSEVIER. DOI |
| 2020 | Tavakoli, P. S., Eadie, L. N., Heatley, S. L., Yeung, D. T., & White, D. L. (2020). The MYB-TYK2 gene fusion induces B-cell acute lymphoblastic leukaemia in in vitro and in vivo models and can be effectively targeted by the dual SYK/JAK inhibitor, cerdulatinib. Poster session presented at the meeting of 25th Congress of The European Hematology Association. Frankfurt, Germany (virtual meeting). |
| 2020 | Rehn, J. A., Breen, J., Heatley, S. L., McClure, B. J., Eadie, L. N., Schutz, C. E., . . . White, D. L. (2020). Targeted pseudo-alignment technique for rapid and accurate identification of disease-causing variants in acute lymphoblastic leukaemia. Poster session presented at the meeting of 14th Annual Florey Postgraduate Conference. Adelaide, South Australia. |
| 2020 | Rehn, J. A., Breen, J., Heatley, S. L., McClure, B. J., Eadie, L. N., Schutz, C. E., . . . White, D. L. (2020). Pseudo-alignment technique for accurate detection of disease-causing variants in acute lymphoblastic leukaemia. Poster session presented at the meeting of Australian Bioinformatics and Computational Biology Society (ABACBS) 2020 National Conference. Canberra, ACT. |
| 2020 | Tavakoli, P. S., Eadie, L. N., Heatley, S. L., Yeung, D. T., & White, D. L. (2020). Vorinostat treatment demonstrated efficacy against MYB-TYK2 altered B-cell acute lymphoblastic leukaemia in in vitro and in vivo models. Poster session presented at the meeting of ASMR Annual Scientific Meeting. Adelaide, South Australia. |
| 2020 | Tavakoli, P. S., Eadie, L. N., Heatley, S. L., Bruning, J. B., & White, D. L. (2020). Persistent activation of JAK/STAT signaling plays an important role in in vitro Jaki resistance in TYK2-rearranged B-Cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of 62nd Annual Meeting of the American Society of Hematology. San Diego, California (virtual conference). |
| 2020 | Eadie, L., Heatley, S., McClure, B., Schutz, C., Breen, J., Hughes, T., . . . White, D. (2020). Next Generation Genomic Analyses Inform Druggable Targets In T-All Patients. Poster session presented at the meeting of Australian & New Zealand Children’s Haematology/Oncology Group. |
| 2020 | McClure, B., Heatley, S., Grose, R., Yeung, D., & White, D. (2020). Activation of the immune cell repertoire in B-cell acute lymphoblastic leukaemia.. Poster session presented at the meeting of Australian & New Zealand Children’s Haematology/Oncology Group. |
| 2020 | Page, E. C., Heatley, S. L., Thomas, P. Q., & White, D. L. (2020). Inducible Knockout of <i>HMGN1</i> in an <i>In Vivo</i> xenograft Model Reduces Down Syndrome Leukemic Burden and Increases Survival Outcomes. Poster session presented at the meeting of BLOOD. ELECTR NETWORK: ELSEVIER. DOI |
| 2019 | Yeung, D., Greenwood, M., Rehn, J., Heatley, S., McClure, B., Eadie, L., . . . White, D. (2019). High risk genomic alterations identified at the time of diagnosis are strongly associated with MRD and subsequent poor outcomes in AYA ALL patients treated on a pediatric inspired chemotherapy regimen. Poster session presented at the meeting of Blood. Orlando, CA: American Society of Hematology. DOI |
| 2019 | Page, E. C., Heatley, S. L., Yeung, D. T., Thomas, P. Q., & White, D. L. (2019). A Novel Role for <i>HMGN1</i> in Down Syndrome Acute Lymphoblastic Leukemia. Poster session presented at the meeting of BLOOD. FL, Orlando: ELSEVIER. DOI |
| 2019 | Tavakoli, P. S., Eadie, L., Heatley, S. L., & White, D. L. (2019). The dual SYK/JAK inhibitor cerdulatinib demonstrates in vitro efficacy against a novel MYB-TYK2 fusion protein in acute lymphoblastic leukaemia cells. Poster session presented at the meeting of Australian and New Zealand Children’s Haematology/Oncology Group (ANZCHOG) Scientific Meeting 2019. Christchurch, New Zealand. |
| 2019 | Eadie, L., Heatley, S. L., McClure, B. J., Rehn, J. A., Breen, J., Hughes, T. P., . . . White, D. L. (2019). Exploration of the Genomic Diversity in T-ALL Patients Using mRNA Sequencing. Poster session presented at the meeting of 1st European Society of Haematology (ESH) Translational Conference on ALL. Berlin, Germany. |
| 2019 | Eadie, L., Heatley, S. L., McClure, B. J., Rehn, J. A., Breen, J., Hughes, T. P., . . . White, D. L. (2019). Exploration of the Genomic Diversity in T-ALL Patients Using mRNA Sequencing. Poster session presented at the meeting of ASMR Annual Scientific Meeting. Adelaide, South Australia. |
| 2019 | Rehn, J. A., Breen, J., Heatley, S. L., McClure, B. J., Eadie, L., Schutz, C. E., . . . White, D. L. (2019). Investigating “alignment-free” computational techniques for the accurate identification of Acute Lymphoblastic Leukaemia (ALL) gene fusion events. Poster session presented at the meeting of SAHMRI Annual Scientific Meeting. Adelaide, South Australia. |
| 2019 | Heatley, S. L., McClure, B. J., Eadie, L. N., Rehn, J. A., Breen, J., Hughes, T. P., . . . White, D. L. (2019). Exploring the genomic diversity of AYA and adult high-risk B-ALL cases by mRNA sequencing. Poster session presented at the meeting of SAHMRI Annual Scientific Meeting. Adelaide, South Australia. |
| 2019 | Toomes, C., McClure, B., Mayne, B., Bruning, J., Heatley, S., Kok, C., . . . White, D. (2019). Identification and characterisation of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster, Australian Society for Medical Research (ASMR) SA Meeting. |
| 2018 | Asari, K., Leclercq, T., Srihari, S., Fitter, S., Yeung, D., Hughes, T., . . . White, D. L. (2018). in vitro modelling of Ph-like ALL uncovers novel genomic alterations associated with TKI-resistance as a consequence of targeted therapy. Poster session presented at the meeting of Childhood Leukaemia and Lymphoma Symposium. Helsinki, Finland. |
| 2018 | Heatley, S. L., Mayne, B. T., McClure, B. J., Kok, C., Sadras, T., Dang, P., . . . White, D. L. (2018). Exploring the genomic diversity of AYA and adult high-risk B-ALL cases by mRNA sequencing. Poster session presented at the meeting of 23rd Congress of European Hematology Association. Stockholm, Sweden. |
| 2018 | Downes, C. E., McClure, B. J., Heatley, S. L., Yeung, D. T., & White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk B-ALL JAK2-fusion. Poster session presented at the meeting of Poster, New Directions in Leukaemia Research (NDLR). |
| 2018 | Heatley, S. L., McClure, B. J., Kok, C., Sadras, T., Dang, P., Galbraith, K., . . . White, D. L. (2018). Exploring the genomic diversity of adult and AYA cases with high-risk B-ALL by mRNA sequencing. Poster session presented at the meeting of NDLR. |
| 2018 | Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster, Adelaide Protein Group (APG) Student Awards. |
| 2018 | Page, E. C., Heatley, S. L., Thomas, P., & White, D. L. (2018). Precision medicine approaches may be the future for CRLF2 rearranged Down Syndrome Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of ASMR. |
| 2018 | Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk JAK2 fusion in B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of Oral, Australian Society for Medical Research (ASMR) SA Meeting. |
| 2018 | Tavakoli Shiraz, P., Eadie, L. N., Heatley, S. L., & White, D. L. (2018). The dual SYK/JAK inhibitor cerdulatinib demonstrates in vitro efficacy against a novel MYB-TYK2 fusion protein in acute lymphoblastic leukaemia cells. Poster session presented at the meeting of ASMR. |
| 2018 | Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and Characterisation of Ruxolitinib Resistant Mutations in JAK2-rearranged B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Poster, Australasian Genomic Technologies Association (AGTA) Annual Conference. |
| 2018 | Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk B-ALL JAK2-fusion. Poster session presented at the meeting of Poster, Australian and New Zealand Children's Haematology/Oncology Group (ANZCHOG) Annual Scientific Meeting. |
| 2018 | Tavakoli Shiraz, P., Eadie, L. N., Heatley, S. L., & White, D. L. (2018). The dual SYK/JAK inhibitor cerdulatinib demonstrates in vitro efficacy against a novel MYB-TYK2 fusion protein in acute lymphoblastic leukaemia cells. Poster session presented at the meeting of SAHMRI Scientific Seminar. |
| 2018 | Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster, South Australian Health and Medical Research Institute (SAHMRI) Annual Scientific Meeting. |
| 2018 | Tavakoli Shiraz, P., Eadie, L. N., Heatley, S. L., & White, D. L. (2018). The dual SYK/JAK inhibitor cerdulatinib demonstrates in vitro efficacy against a novel MYB-TYK2 fusion protein in acute lymphoblastic leukaemia cells. Poster session presented at the meeting of 12th Annual Florey postgraduate Conference. |
| 2018 | Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster, European Molecular Biology Laboratory (EMBL) Australia Postgraduate Symposium. |
| 2018 | Tavakoli Shiraz, P., Eadie, L. N., Heatley, S. L., & White, D. L. (2018). The dual SYK/JAK inhibitor cerdulatinib demonstrates in vitro efficacy against a novel MYB-TYK2 fusion protein in acute lymphoblastic leukaemia cells. Poster session presented at the meeting of EMBL Australia Postgraduate Symposium. |
| 2017 | McClure, B. J., Heatley, S. L., Kok, C., Sadras, T., An, J., Quek, K., . . . White, D. L. (2017). EP300-ZNF384 is a recurrent fusion gene with distinct gene expression in adolescent/young adult pre-B-ALL patients. Poster session presented at the meeting of ANZCHOG. |
| 2017 | Heatley, S. L., Sadras, T., Kok, C., Nievergall, E., Quek, K., Dang, P., . . . White, D. L. (2017). High Prevalence of Relapse in Australian Children with Ph-like Acute Lymphoblastic Leukemia Despite Risk-Adapted Treatment. Poster session presented at the meeting of ANZCHOG. |
| 2017 | Asari, K., Sadras, T., Srihari, S., Fitter, S., An, J., Zannettino, A. C., . . . White, D. L. (2017). in vitro Modelling of Ph-like ALL Fusions Uncovers Novel Kinase-domain Mutations as a Mode of TKI-resistance and Potential Consequence of Targeted TKI Therapy. Poster session presented at the meeting of ANZCHOG. |
| 2017 | McClure, B. J., Heatley, S. L., Sadras, T., Sutton, R., & White, D. L. (2017). EP300-ZNF384 is a recurrent fusion gene with distinct gene expression in adolescent/young adult Australian pre-B-acute lymphoblastic leukaemia. Poster session presented at the meeting of IBFM. |
| 2017 | Heatley, S., Sadras, T., Kok, C., Nievergall, E., Quek, K., Dang, P., . . . White, D. (2017). High prevalence of relapse in children with Philadelphia-like acute lymphoblastic leukemia despite risk-adapted treatment. Poster session presented at the meeting of Abstracts of the 57th Annual Meeting of the American Society of Hematology, as published in Blood. Orlando, FL: American Society of Hematology. DOI WoS2 |
| 2017 | Downes, C. E., McClure, B. M., Heatley, S. H., Sadras, T. S., Hughes, T. H., Kok, C. K., . . . White, D. W. (2017). Identification and cloning of a novel GOLGA4-JAK2 fusion from an adult patient with B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Poster, Australian Society for Medical Research (ASMR) SA Meeting. Adelaide. |
| 2016 | Heatley, S., Sadras, T., kok, C., Venn, N., Revesz, T., Osborn, M., . . . White, D. L. (2016). Australian Children with Ph-like ALL enrolled to ANZCHOG ALL8 had a high prevalence of relapse despite risk adapted treatment. Poster session presented at the meeting of CLS SCIENTIFIC PROGRAMME, Refractory Leukemia and Miscellaneous. Athens. |
| 2016 | Sadras, T., Heatley, S., Dang, P., Kok, C., Quek, K., Nievergall, E., . . . White, D. L. (2016). A nine-gene signature defines 2 groups of CRLF2 rearranged B-ALL patients with distinctive genetic features. Poster session presented at the meeting of .. Athens. |
| 2016 | Pagani, I. S., Kok, C., Saunders, V., Goyne, J., McLean, J., Vanderhoek, M., . . . Ross, D. (2016). The genomic landscape of mitochondrial DNA mutations in chronic myeloid leukaemia. Poster session presented at the meeting of .. Barcelona, Spain. |
| 2016 | Sadras, T., Heatley, S., Kok, C., Quek, K., Dang, P., Nievergall, E., . . . White, D. L. (2016). CRLF2 rearranged B-ALL cases with a Ph-like gene signature are enriched for JAK2 mutations. Poster session presented at the meeting of .. Noosa, QLD. |
| 2016 | McClure, B., Heatley, S., Sadras, T., Nievergall, E., Kok, C., Dang, P., . . . White, D. L. (2016). Identification of a significantly high prevalence of relapse in Australian children with Ph-like ALL. Poster session presented at the meeting of .. Noosa, QLD. |
| 2016 | Asari, K., Heatley, S., Leclercq, T., Fitter, S., Zannettino, A., Hughes, T., & White, D. L. (2016). In vitro Modelling of Therapeutic Resistance to Elucidate Mechanisms of TKI-Resistant High-Risk ALL. Poster session presented at the meeting of .. Noosa, QLD. |
| 2016 | Pagani, I., Kok, C., Saunders, V., Goyne, J., McLean, J., Vanderhoek, M., . . . White, D. L. (2016). Do mitochondrial mutations in chronic myeloid leukaemia identify a pre-leukemic clone?. Poster session presented at the meeting of .. Noosa, QLD. |
| 2016 | White, D. L., McClure, B., Heatley, S., Sadras, T., Quek, K., & Hughes, T. (2016). Investigation of the transforming capacity of a recently identified EP300-ZNF384 fusion gene in adult acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA. |
| 2016 | Asari, K., Heatley, S., Leclercq, T., Fitter, S., Kok, C. H., Zannettino, A., . . . White, D. L. (2016). Investigating Modes of Therapeutic Resistance via In Vitro Modelling of TKI-resistant High-Risk Philadelphia-chromosome-positive and Philadelphia-chromosome-like Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA. |
| 2016 | Galbraith, K., Sadras, T., McClure, B., Heatley, S., & White, D. L. (2016). Identification of novel therapeutic targets in CRLF2 rearranged acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA. |
| 2016 | Heatley, S., Sadras, T., McClure, B., Kok, C. H., Dang, P., Nievergall, E., . . . White, D. L. (2016). The Incidence of Ph-like Acute Lymphoblastic Leukaemia (ALL) Increases with Age and is Characterised by Poor Outcome. Poster session presented at the meeting of Poster Session. Melbourne, VIC. |
| 2016 | Pagani, I. S., Kok, C. H., Wang, J., Saunders, V., Van der Hoek, M., Heatley, S., . . . Ross, D. (2016). Mitochondrial DNA Mutations at Diagnosis are Linked to Response in TKI treated Chronic Myeloid Leukaemia Patients. Poster session presented at the meeting of Poster Session. Melbourne, VIC. |
| 2015 | Zaliova, M., Moorman, A., Cazzaniga, G., Stanulla, M., Harvey, R., Roberts, K., . . . Zuna, J. (2015). Characterization of Leukemias with ETV6-ABL1 Fusion. Poster session presented at the meeting of BLOOD. Orlando, FL: AMER SOC HEMATOLOGY. |
| 2015 | Sadras, T., Heatley, S., Nievergall, E., Kok, C., Dang, P., Yeung, D., . . . White, D. (2015). JAK2 MUTATIONS ARE HIGHLY ENRICHED IN CRLF2-REARRANGED B-ALL CASES WITH A PH-LIKE GENE SIGNATURE. Poster session presented at the meeting of HAEMATOLOGICA. Vienna, AUSTRIA: FERRATA STORTI FOUNDATION. WoS1 |
| 2014 | Nievergall, E., Heatley, S., Kok, C., Dang, P., Frede, A., Moore, S., . . . White, D. (2014). THE INCIDENCE OF THE HIGH-RISK PH-LIKE ALL SUBTYPE MAY ACCOUNT FOR THE MAJORITY OF NON BCR-ABL1+B ALL CASES IN ADULTS. Poster session presented at the meeting of HAEMATOLOGICA. Milan, ITALY: FERRATA STORTI FOUNDATION. |
Grant Funding:
2024 Channel 7 Children’s Research Foundation $100,000: Using Single Cell Sequencing to Elucidate the Clonal Evolution of Acute Lymphoblastic Leukaemia to Prevent Relapse in Children and Improve Outcomes.
July 1 2016- June 30 2018 & July 1 2019- Dec 2022 The Kids Cancer Project $436,015 Elucidating drug sensitivity and clonal evolution of Ph-like ALL in adolescents.
Fellowship: Susan Heatley
2015 Channel 7 Children’s Research Foundation $75,000
Developing a robust screening tool to identify children with high risk “Ph-like” Acute Lymphoblastic Leukaemia (ALL) that will lead to improved outcomes through the use of targeted therapies.
CIA Susan Heatley, CIB Deborah White, CIC Charles Mullighan
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2024 | External Supervisor | Identifying Predictors of CNS involvement in Acute Lymphoblastic Leukaemia | Doctor of Philosophy | Doctorate | Full Time | Mr Luke Jacob Quinlan |
| 2024 | External Supervisor | Identifying Predictors of CNS involvement in Acute Lymphoblastic Leukaemia | Doctor of Philosophy | Doctorate | Full Time | Mr Luke Jacob Quinlan |
| 2023 | External Supervisor | Interrogating the DUX4 rearranged subtype of B cell Acute Lymphoblastic Leukaemia | Doctor of Philosophy | Doctorate | Full Time | Mr Thomas Oliver McGovern |
| 2023 | External Supervisor | Interrogating the DUX4 rearranged subtype of B cell Acute Lymphoblastic Leukaemia | Doctor of Philosophy | Doctorate | Full Time | Mr Thomas Oliver McGovern |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2018 - 2021 | Co-Supervisor | Exploring the cooperation and targetability of CRLF2 and HMGN1 in Down Syndrome Acute Lymphoblastic Leukaemia | Doctor of Philosophy | Doctorate | Full Time | Miss Elyse Chenae Page |
| 2017 - 2021 | Co-Supervisor | Characterising the novel MYB-TYK2 fusion gene in high-risk acute lymphoblastic leukaemia: oncogenic potential, effective therapeutic strategies and In vitro modelling of drug resistance mechanisms | Doctor of Philosophy | Doctorate | Full Time | Miss Paniz Tavakoli Shirazi |
| 2015 - 2018 | Co-Supervisor | In vitro Modelling of High-risk ALL Fusions Uncovers Genomic Alterations and Non-canonical Signalling Pathways as a Mode of TKI-Resistance - Implications for Targeted Therapy | Doctor of Philosophy | Doctorate | Full Time | Miss Kartini Asari |
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