Sue Heatley
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Sue Heatley
Postdoctoral Research Fellow
South Australian Health & Medical Research Institute
Previous:
The Kids Cancer Project Postdoctoral Fellow (2016-2022)
Centre for Cancer Biology,
Australian Red Cross Blood Service,
St Jude Children's Research Hospital
Education:
University of Melbourne
Experience:
Genomics Research Team Leader
South Australian Health & Medical Research Institute
July 2013 – Dec 2016|Adelaide
Postdoctoral Scientist
Centre for Cancer Biology
August 2011 – June 2013 (1 year 11 months)|Adelaide
Medical Education Project Officer
Australian Red Cross Blood Service
July 2009 – August 2011 (2 years 2 months)|Adelaide
Visiting Postdoctoral Fellow
St Jude Children's Research Hospital
June 2010 – February 2011 (9 months)|Memphis, TN, USA
Medical Scientist, Research & Development
Australian Red Cross Blood Service
January 1998 – June 2009 (11 years 6 months)|Adelaide
Medical Scientist/Technical Officer/Nurse attendant
Australian Red Cross Blood Service
October 1984 – December 1997 (13 years 3 months)|Adelaide
Dr Sue Heatley gained her PhD in Transplant Immunology from the University of Melbourne in 2011. She also has a Masters in Education (Educational Leadership). In 2010 she was awarded a New Investigator Scholarship by the Haematology Society of Australia & New Zealand (HSANZ) to undertake a visiting fellow position in the laboratory of Prof Charles Mullighan at the St Jude’s Children’s Research Hospital, Memphis, TN, USA. In 2013, Sue accepted her current position at SAHMRI in the Leukaemia Research group of Prof Deb White and Prof Tim Hughes in the Cancer Theme. She is a member of several professional societies including HSANZ and the Australian & New Zealand Children’s Haematology and Oncology Group.
Sue has extensive laboratory experience having worked at the Australian Red Cross Blood Service for over 25 years including over 12 years in the Research Department and 2 years in Medical Education. She has presented her research at both national and international meetings, being awarded the prestigious Albert Baikie Memorial Medal in 2015 for best presentation by a new investigator. Sue has authored over 30 publications with over 3000 career citations and is the current Kids Cancer Project Postdoctoral Fellow. Her current research interests are focussed on the genomic landscape of ALL and improving patient outcome through personalised medicine.
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Appointments
Date Position Institution name 2013 - ongoing Affiliate Senior Lecturer University of Adelaide -
Awards and Achievements
Date Type Title Institution Name Country Amount 2016 Award HSANZ Travel Award Haematology Society of Australia and New Zealand Australia $1000 2016 Fellowship The Kids Cancer Project Postdoctoral Fellow - Australia $170,932 2015 Award Albert Baikie Memorial Award Haematology Society of Australia and New Zealand Australia $3000 2009 Award ASHI International Scholar American Society for Histocompatability and Immunogenetics United States - 2009 Achievement Presidential Symposium Haematology Society of Australia and New Zealand Australia - 2009 Scholarship New Investigator Scholarship Haematology Society of Australia and New Zealand Australia $30,000 -
Education
Date Institution name Country Title 2011 - 2012 Charles Sturt University Australia Master of Education 2004 - 2011 University of Melbourne Australia PhD 2002 - 2004 Charles Sturt University Australia Bachelor of Medical Science (Honours) 1996 - 1999 Charles Sturt University Australia Bachelor of Medical Science (Pathology) -
Postgraduate Training
Date Title Institution Country 2010 - 2011 Visting Postdoctoral Fellow St Jude Children's Research Hospital United States -
Research Interests
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Journals
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Books
Year Citation 2020 Tavakoli, P. S., Eadie, L., Heatley, S. L., Yeung, D. T., & White, D. L. (2020). The MYB-TYK2 gene fusion induces B-cell acute lymphoblastic leukaemia in in vitro and in vivo models and can be effectively targeted by the dual SYK/JAK inhibitor, cerdulatinib (Vol. 4). Lippincott, Williams & Wilkins.
DOI -
Conference Papers
Year Citation 2023 White, D. L., Rehn, J. A., Schutz, C. E., Heatley, S. L., Eadie, L. N., Thomson, A., . . . Greenwood, M. (2023). Improved MRD Negativity Rates in Adverse Genomic Risk B-ALL Patients with Chemotherapy / Blinatumomab Induction: Experience from the Australasian Leukaemia Lymphoma Group (ALLG) ALL06/09 Studies. In BLOOD Vol. 142 (pp. 6 pages). CA, San Diego: AMER SOC HEMATOLOGY.
DOI2023 Eadie, L. N., Schutz, C. E., Page, E. C., Conlin, T. S., Heatley, S. L., Lagonik, E., . . . White, D. L. (2023). Asciminib Is Effective Against ABL1 Gene Fusions in Acute Lymphoblastic Leukemia but Only When the ABL1 SH3 Domain Is Present. In BLOOD Vol. 142 (pp. 4 pages). CA, San Diego: AMER SOC HEMATOLOGY.
DOI2021 Page, E. C., Heatley, S. L., Rehn, J., Yeung, D. T., Thomas, P. Q., & White, D. L. (2021). <i>HMGN1</i> expression Predisposes Down Syndrome Patients to Develop <i>P2RY8-CRLF2</i> acute Lymphoblastic Leukemia. In BLOOD Vol. 138 (pp. 4 pages). Atlanta, GA: AMER SOC HEMATOLOGY.
DOI2019 Dean, M. M., Lopez, G. H., Liley, H. G., Heatley, S. L., & Minchinton, R. M. (2019). Development of functional mannose binding lectin is delayed in extremely low birth weight infants. In JOURNAL OF IMMUNOLOGY Vol. 202 (pp. 3 pages). San Diego, CA: AMER ASSOC IMMUNOLOGISTS. 2016 Pagani, I. S., Kok, C. H., Saunders, V., Goyne, J., McLean, J., VanderHoek, M., . . . Ross, D. M. (2016). The genomic landscape of mitochondrial DNA mutations in chronic myeloid leukaemia.. In European Journal of Human Genetics. Barcelona: Natue Publishing Group. 2016 Asari, K., Heatley, S. L., Sadras, T., Leclercq, T. M., Fitter, S., Kok, C. H., . . . White, D. L. (2016). <i>In Vitro</i> Modeling of Ph-like ALL Fusions Identifies Novel Kinase-Domain Mutations As Mode of TKI-Resistance Implications for Targeted Therapy. In BLOOD Vol. 128 (pp. 5 pages). San Diego, CA: AMER SOC HEMATOLOGY.
DOI2016 Pagani, I. S., Kok, C. H., Wang, J., Saunders, V., Goyne, J., McLean, J., . . . Ross, D. M. (2016). MITOCHONDRIAL DNA MUTATIONS IDENTIFY CLONAL HETEROGENEITY IN CHRONIC MYELOID LEUKAEMIA. In HAEMATOLOGICA Vol. 101 (pp. 234). Copenhagen, DENMARK: FERRATA STORTI FOUNDATION. 2016 Zaliova, M., Moorman, A. V., Cazzaniga, G., Stanulla, M., Harvey, R. C., Roberts, K. G., . . . Zuna, J. (2016). Characterization of leukemias with ETV6-ABL1 fusion. In Proceedings of the 57th Annual Meeting of the American-Society-of-Hematology, as published in Haematologica Vol. 101 (pp. 1082-1093). Orlando, FL: Ferrata Storti Foundation.
DOI Scopus70 WoS44 Europe PMC452015 Hiwase, D., Hahn, C., Babic, M., Moore, S., Singhal, D., Kutyna, M., . . . Scott, H. (2015). MULTIPLE MUTATIONS IN THE SAME GENE SUGGEST CLONAL DIVERSITY AND IS ASSOCIATED WITH POOR PROGNOSIS IN MDS. In LEUKEMIA RESEARCH Vol. 39 (pp. S77-S78). Washington, DC: PERGAMON-ELSEVIER SCIENCE LTD.
DOI2011 Zhang, J., Ding, L., Holmfeldt, L., Wu, G., Heatley, S. L., Payne-Turner, D., . . . Mullighan, C. G. (2011). Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project. In BLOOD Vol. 118 (pp. 32-33). San Diego, CA: AMER SOC HEMATOLOGY. 2010 Mullighan, C., Zhang, J., Kasper, L. H., Lerach, S., Payne-Turner, D., Phillips, L. A., . . . Downing, J. R. (2010). <i>CREBBP</i> Mutations In Relapsed Acute Lymphoblastic Leukemia. In BLOOD Vol. 116 (pp. 184). Orlando, FL: AMER SOC HEMATOLOGY.
WoS12010 Heatley, S. L., Mullighan, C. G., Sullivan, L. C., Brooks, A. G., Szer, J., Bradstock, K., . . . Bardy, P. G. (2010). KIR HAPLOTYPE MAY INFLUENCE CLINICAL OUTCOME FOLLOWING HLA-MATCHED SIBLING HAEMOPOIETIC STEM CELL TRANSPLANTATION. In BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION Vol. 16 (pp. S270). ELSEVIER SCIENCE INC.
DOI2009 Heatley, S., Mullighan, C., Sullivan, L., Brooks, A., & Bardy, P. (2009). THE EFFECT OF KIR HAPLOTYPE ON CLINICAL OUTCOME FOLLOWING HLA-MATCHED SIBLING HAEMOPOIETIC STEM CELL TRANSPLANTATION. In HUMAN IMMUNOLOGY Vol. 70 (pp. S169). San Francisco, CA: ELSEVIER SCIENCE INC.
DOI2007 Hurst, N., Mullighan, C. G., Heatley, S. L., Robinson, K., Danner, S., Hahn, U., . . . Bardy, P. G. (2007). Risk factors for blood product usage following sibling allogeneic haemopoietic stem cell transplantation (allo-HCT). In BLOOD Vol. 110 (pp. 856A). Atlanta, GA: AMER SOC HEMATOLOGY.
DOI2006 Mullighan, C., Heatley, S. L., Villalta, N. R., Doherty, K. V., Danner, S., Hahn, U., . . . Bardy, P. G. (2006). Extended <i>TNF</i> genotyping identifies <i>TNF</i>-857T as a risk factor for acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.. In BLOOD Vol. 108 (pp. 16A). Orlando, FL: AMER SOC HEMATOLOGY.
DOI2000 Bardy, P., Grigg, A. P., Szer, J., Roberts, A., Schwarer, A. P., Spencer, A., . . . Hughes, T. P. (2000). Successful engraftment with disease response following sibling allograft with reduced conditioning, T-cell depletion and delayed incremental DLI in CML and MM.. In BLOOD Vol. 96 (pp. 783A). AMER SOC HEMATOLOGY. -
Conference Items
Year Citation 2022 Thomson, A., Rehn, J., Heatley, S., Eadie, L., McClure, B., Page, E., . . . White, D. (2022). Benchmarking the detection rate of IGH gene fusions in B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Australian Bioinformatics and Computational Biology Society (ABACBS) Conference. 2021 Heatley, S. L., Page, E. C., Eadie, L. N., McClure, B. J., Rehn, J., Yeung, D. T., . . . White, D. L. (2021). Modeling Relapsed, Refractory Acute Lymphoblastic Leukemia from a Child with Neurofibromatosis. Poster session presented at the meeting of BLOOD. Atlanta, GA: AMER SOC HEMATOLOGY.
DOI2021 Eadie, L., Heatley, S., McClure, B., Rehn, J., Schutz, C., Breen, J., . . . White, D. (2021). Next Generation Genomic Analyses Inform Druggable Targets In T-All Patients. Poster session presented at the meeting of 4th International T-ALL/T-NHL conference: T-ALL2020: Omics, genetics and therapy. 2021 McClure, B., Heatley, S., Grose, R., & White, D. (2021). Activation of the immune cell repertoire in B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of 12th Biennial Childhood Leukemia and Lymphoma Symposium (CLLS). 2021 Eadie, L., Heatley, S., McClure, B., Rehn, J., Schutz, C., Breen, J., . . . White, D. (2021). Next Generation Genomic Analyses Inform Druggable Targets In T-All Patients. Poster session presented at the meeting of 12th Biennial Childhood Leukemia and Lymphoma Symposium (CLLS). 2021 Heatley, S., Rehn, J., Breen, J., Moore, A., Sutton, R., Osborn, M., & White, D. (2021). Using single cell mRNAseq to interrogate the genomic consequences of Ph-like acute lymphoblastic leukaemia in adolescents. Poster session presented at the meeting of 12th Biennial Childhood Leukemia and Lymphoma Symposium (CLLS). 2020 Page, E., Heatley, S., Thomas, P., & White, D. (2020). HMGN1 is necessary for Down Syndrome leukaemic cell proliferation and cooperates with CRLF2 for leukaemic transformation. Poster session presented at the meeting of The 59th ASMR National Scientific Conference. 2020 Tavakoli, P. S., Eadie, L. N., Heatley, S. L., Yeung, D. T., & White, D. L. (2020). The MYB-TYK2 gene fusion induces B-cell acute lymphoblastic leukaemia in in vitro and in vivo models and can be effectively targeted by the dual SYK/JAK inhibitor, cerdulatinib. Poster session presented at the meeting of 25th Congress of The European Hematology Association. Frankfurt, Germany (virtual meeting). 2020 Rehn, J. A., Breen, J., Heatley, S. L., McClure, B. J., Eadie, L. N., Schutz, C. E., . . . White, D. L. (2020). Targeted pseudo-alignment technique for rapid and accurate identification of disease-causing variants in acute lymphoblastic leukaemia. Poster session presented at the meeting of 14th Annual Florey Postgraduate Conference. Adelaide, South Australia. 2020 Rehn, J. A., Breen, J., Heatley, S. L., McClure, B. J., Eadie, L. N., Schutz, C. E., . . . White, D. L. (2020). Pseudo-alignment technique for accurate detection of disease-causing variants in acute lymphoblastic leukaemia. Poster session presented at the meeting of Australian Bioinformatics and Computational Biology Society (ABACBS) 2020 National Conference. Canberra, ACT. 2020 Tavakoli, P. S., Eadie, L. N., Heatley, S. L., Yeung, D. T., & White, D. L. (2020). Vorinostat treatment demonstrated efficacy against MYB-TYK2 altered B-cell acute lymphoblastic leukaemia in in vitro and in vivo models. Poster session presented at the meeting of ASMR Annual Scientific Meeting. Adelaide, South Australia. 2020 Tavakoli, P. S., Eadie, L. N., Heatley, S. L., Bruning, J. B., & White, D. L. (2020). Persistent activation of JAK/STAT signaling plays an important role in in vitro Jaki resistance in TYK2-rearranged B-Cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of 62nd Annual Meeting of the American Society of Hematology. San Diego, California (virtual conference). 2020 Eadie, L. N., Rehn, J., Heatley, S. L., McClure, B. J., Schutz, C. S., Breen, J., . . . White, D. L. (2020). Next Generation Genomic Analyses in T-ALL Patients Identify Recurrent and Novel Genomic Abnormalities. Poster session presented at the meeting of BLOOD. ELECTR NETWORK: AMER SOC HEMATOLOGY.
DOI WoS12020 Tavakoli, P., Eadie, L. N., Heatley, S. L., Bruning, J. B., & White, D. L. (2020). Persistent Activation of JAK/STAT Signaling Plays an Important Role in<i>in Vitro</i>Jaki Resistance in <i>TYK2</i>-rearranged B-Cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of BLOOD. ELECTR NETWORK: AMER SOC HEMATOLOGY.
DOI2020 Eadie, L., Heatley, S., McClure, B., Schutz, C., Breen, J., Hughes, T., . . . White, D. (2020). Next Generation Genomic Analyses Inform Druggable Targets In T-All Patients. Poster session presented at the meeting of Australian & New Zealand Children’s Haematology/Oncology Group. 2020 McClure, B., Heatley, S., Grose, R., Yeung, D., & White, D. (2020). Activation of the immune cell repertoire in B-cell acute lymphoblastic leukaemia.. Poster session presented at the meeting of Australian & New Zealand Children’s Haematology/Oncology Group. 2020 Page, E., Heatley, S., Thomas, P., & White, D. (2020). Inducible Knockout of HMGN1 in an In Vivo xenograft Model Reduces Down Syndrome Leukemic Burden and Increases Survival Outcomes. Poster session presented at the meeting of 62nd ASH ANNUAL MEETING AND EXPOSITION. 2019 Tavakoli, P. S., Eadie, L., Heatley, S. L., & White, D. L. (2019). The dual SYK/JAK inhibitor cerdulatinib demonstrates in vitro efficacy against a novel MYB-TYK2 fusion protein in acute lymphoblastic leukaemia cells. Poster session presented at the meeting of Australian and New Zealand Children’s Haematology/Oncology Group (ANZCHOG) Scientific Meeting 2019. Christchurch, New Zealand. 2019 Eadie, L., Heatley, S. L., McClure, B. J., Rehn, J. A., Breen, J., Hughes, T. P., . . . White, D. L. (2019). Exploration of the Genomic Diversity in T-ALL Patients Using mRNA Sequencing. Poster session presented at the meeting of 1st European Society of Haematology (ESH) Translational Conference on ALL. Berlin, Germany. 2019 Eadie, L., Heatley, S. L., McClure, B. J., Rehn, J. A., Breen, J., Hughes, T. P., . . . White, D. L. (2019). Exploration of the Genomic Diversity in T-ALL Patients Using mRNA Sequencing. Poster session presented at the meeting of ASMR Annual Scientific Meeting. Adelaide, South Australia. 2019 Rehn, J. A., Breen, J., Heatley, S. L., McClure, B. J., Eadie, L., Schutz, C. E., . . . White, D. L. (2019). Investigating “alignment-free” computational techniques for the accurate identification of Acute Lymphoblastic Leukaemia (ALL) gene fusion events. Poster session presented at the meeting of SAHMRI Annual Scientific Meeting. Adelaide, South Australia. 2019 Heatley, S. L., McClure, B. J., Eadie, L. N., Rehn, J. A., Breen, J., Hughes, T. P., . . . White, D. L. (2019). Exploring the genomic diversity of AYA and adult high-risk B-ALL cases by mRNA sequencing. Poster session presented at the meeting of SAHMRI Annual Scientific Meeting. Adelaide, South Australia. 2019 Page, E. C., Heatley, S. L., Yeung, D. T., Thomas, P. Q., & White, D. L. (2019). A Novel Role for <i>HMGN1</i> in Down Syndrome Acute Lymphoblastic Leukemia. Poster session presented at the meeting of BLOOD. Orlando, FL: AMER SOC HEMATOLOGY.
DOI2019 Yeung, D., Greenwood, M., Rehn, J., Heatley, S., McClure, B., Eadie, L., . . . White, D. (2019). High risk genomic alterations identified at the time of diagnosis are strongly associated with MRD and subsequent poor outcomes in AYA ALL patients treated on a pediatric inspired chemotherapy regimen. Poster session presented at the meeting of Blood. Orlando, CA: American Society of Hematology.
DOI2018 Asari, K., Leclercq, T., Srihari, S., Fitter, S., Yeung, D., Hughes, T., . . . White, D. L. (2018). in vitro modelling of Ph-like ALL uncovers novel genomic alterations associated with TKI-resistance as a consequence of targeted therapy. Poster session presented at the meeting of Childhood Leukaemia and Lymphoma Symposium. Helsinki, Finland. 2018 Heatley, S. L., Mayne, B. T., McClure, B. J., Kok, C., Sadras, T., Dang, P., . . . White, D. L. (2018). Exploring the genomic diversity of AYA and adult high-risk B-ALL cases by mRNA sequencing. Poster session presented at the meeting of 23rd Congress of European Hematology Association. Stockholm, Sweden. 2018 Downes, C. E., McClure, B. J., Heatley, S. L., Yeung, D. T., & White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk B-ALL JAK2-fusion. Poster session presented at the meeting of NDLR. 2018 Heatley, S. L., McClure, B. J., Kok, C., Sadras, T., Dang, P., Galbraith, K., . . . White, D. L. (2018). Exploring the genomic diversity of adult and AYA cases with high-risk B-ALL by mRNA sequencing. Poster session presented at the meeting of NDLR. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of APG Student Awards. 2018 Page, E. C., Heatley, S. L., Thomas, P., & White, D. L. (2018). Precision medicine approaches may be the future for CRLF2 rearranged Down Syndrome Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of ASMR. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk JAK2 fusion in B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of ASMR. 2018 Tavakoli Shiraz, P., Eadie, L. N., Heatley, S. L., & White, D. L. (2018). The dual SYK/JAK inhibitor cerdulatinib demonstrates in vitro efficacy against a novel MYB-TYK2 fusion protein in acute lymphoblastic leukaemia cells. Poster session presented at the meeting of ASMR. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and Characterisation of Ruxolitinib Resistant Mutations in JAK2-rearranged B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of AGTA. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification of mutations that cause ruxolitinib resistance in Pro-B cells driven by a high-risk B-ALL JAK2-fusion.. Poster session presented at the meeting of ANZCHOG. 2018 Tavakoli Shiraz, P., Eadie, L. N., Heatley, S. L., & White, D. L. (2018). The dual SYK/JAK inhibitor cerdulatinib demonstrates in vitro efficacy against a novel MYB-TYK2 fusion protein in acute lymphoblastic leukaemia cells. Poster session presented at the meeting of SAHMRI Scientific Seminar. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of SAHMRI Scientific Seminar. 2018 Tavakoli Shiraz, P., Eadie, L. N., Heatley, S. L., & White, D. L. (2018). The dual SYK/JAK inhibitor cerdulatinib demonstrates in vitro efficacy against a novel MYB-TYK2 fusion protein in acute lymphoblastic leukaemia cells. Poster session presented at the meeting of 12th Annual Florey postgraduate Conference. 2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of EMBL Australia Postgraduate Symposium. 2018 Tavakoli Shiraz, P., Eadie, L. N., Heatley, S. L., & White, D. L. (2018). The dual SYK/JAK inhibitor cerdulatinib demonstrates in vitro efficacy against a novel MYB-TYK2 fusion protein in acute lymphoblastic leukaemia cells. Poster session presented at the meeting of EMBL Australia Postgraduate Symposium. 2017 McClure, B. J., Heatley, S. L., Kok, C., Sadras, T., An, J., Quek, K., . . . White, D. L. (2017). EP300-ZNF384 is a recurrent fusion gene with distinct gene expression in adolescent/young adult pre-B-ALL patients. Poster session presented at the meeting of ANZCHOG. 2017 Heatley, S. L., Sadras, T., Kok, C., Nievergall, E., Quek, K., Dang, P., . . . White, D. L. (2017). High Prevalence of Relapse in Australian Children with Ph-like Acute Lymphoblastic Leukemia Despite Risk-Adapted Treatment. Poster session presented at the meeting of ANZCHOG. 2017 Asari, K., Sadras, T., Srihari, S., Fitter, S., An, J., Zannettino, A. C., . . . White, D. L. (2017). in vitro Modelling of Ph-like ALL Fusions Uncovers Novel Kinase-domain Mutations as a Mode of TKI-resistance and Potential Consequence of Targeted TKI Therapy. Poster session presented at the meeting of ANZCHOG. 2017 McClure, B. J., Heatley, S. L., Sadras, T., Sutton, R., & White, D. L. (2017). EP300-ZNF384 is a recurrent fusion gene with distinct gene expression in adolescent/young adult Australian pre-B-acute lymphoblastic leukaemia. Poster session presented at the meeting of IBFM. 2017 Heatley, S., Sadras, T., Kok, C., Nievergall, E., Quek, K., Dang, P., . . . White, D. (2017). High prevalence of relapse in children with Philadelphia-like acute lymphoblastic leukemia despite risk-adapted treatment. Poster session presented at the meeting of Abstracts of the 57th Annual Meeting of the American Society of Hematology, as published in Blood. Orlando, FL: American Society of Hematology.
DOI WoS22017 Downes, C. E., McClure, B. M., Heatley, S. H., Sadras, T. S., Hughes, T. H., Kok, C. K., . . . White, D. W. (2017). Identification and cloning of a novel GOLGA4-JAK2 fusion from an adult patient with B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Poster session presented at the ASMR SA Scientific Meeting. Adelaide. 2016 Heatley, S., Sadras, T., kok, C., Venn, N., Revesz, T., Osborn, M., . . . White, D. L. (2016). Australian Children with Ph-like ALL enrolled to ANZCHOG ALL8 had a high prevalence of relapse despite risk adapted treatment. Poster session presented at the meeting of CLS SCIENTIFIC PROGRAMME, Refractory Leukemia and Miscellaneous. Athens. 2016 Sadras, T., Heatley, S., Dang, P., Kok, C., Quek, K., Nievergall, E., . . . White, D. L. (2016). A nine-gene signature defines 2 groups of CRLF2 rearranged B-ALL patients with distinctive genetic features. Poster session presented at the meeting of .. Athens. 2016 Pagani, I. S., Kok, C., Saunders, V., Goyne, J., McLean, J., Vanderhoek, M., . . . Ross, D. (2016). The genomic landscape of mitochondrial DNA mutations in chronic myeloid leukaemia. Poster session presented at the meeting of .. Barcelona, Spain. 2016 Sadras, T., Heatley, S., Kok, C., Quek, K., Dang, P., Nievergall, E., . . . White, D. L. (2016). CRLF2 rearranged B-ALL cases with a Ph-like gene signature are enriched for JAK2 mutations. Poster session presented at the meeting of .. Noosa, QLD. 2016 McClure, B., Heatley, S., Sadras, T., Nievergall, E., Kok, C., Dang, P., . . . White, D. L. (2016). Identification of a significantly high prevalence of relapse in Australian children with Ph-like ALL. Poster session presented at the meeting of .. Noosa, QLD. 2016 Asari, K., Heatley, S., Leclercq, T., Fitter, S., Zannettino, A., Hughes, T., & White, D. L. (2016). In vitro Modelling of Therapeutic Resistance to Elucidate Mechanisms of TKI-Resistant High-Risk ALL. Poster session presented at the meeting of .. Noosa, QLD. 2016 Pagani, I., Kok, C., Saunders, V., Goyne, J., McLean, J., Vanderhoek, M., . . . White, D. L. (2016). Do mitochondrial mutations in chronic myeloid leukaemia identify a pre-leukemic clone?. Poster session presented at the meeting of .. Noosa, QLD. 2016 White, D. L., McClure, B., Heatley, S., Sadras, T., Quek, K., & Hughes, T. (2016). Investigation of the transforming capacity of a recently identified EP300-ZNF384 fusion gene in adult acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA. 2016 Asari, K., Heatley, S., Leclercq, T., Fitter, S., Kok, C. H., Zannettino, A., . . . White, D. L. (2016). Investigating Modes of Therapeutic Resistance via In Vitro Modelling of TKI-resistant High-Risk Philadelphia-chromosome-positive and Philadelphia-chromosome-like Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA. 2016 Galbraith, K., Sadras, T., McClure, B., Heatley, S., & White, D. L. (2016). Identification of novel therapeutic targets in CRLF2 rearranged acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA. 2016 Heatley, S., Sadras, T., McClure, B., Kok, C. H., Dang, P., Nievergall, E., . . . White, D. L. (2016). The Incidence of Ph-like Acute Lymphoblastic Leukaemia (ALL) Increases with Age and is Characterised by Poor Outcome. Poster session presented at the meeting of Poster Session. Melbourne, VIC. 2016 Pagani, I. S., Kok, C. H., Wang, J., Saunders, V., Van der Hoek, M., Heatley, S., . . . Ross, D. (2016). Mitochondrial DNA Mutations at Diagnosis are Linked to Response in TKI treated Chronic Myeloid Leukaemia Patients. Poster session presented at the meeting of Poster Session. Melbourne, VIC. 2015 Zaliova, M., Moorman, A., Cazzaniga, G., Stanulla, M., Harvey, R., Roberts, K., . . . Zuna, J. (2015). Characterization of Leukemias with ETV6-ABL1 Fusion. Poster session presented at the meeting of BLOOD. Orlando, FL: AMER SOC HEMATOLOGY. 2015 Sadras, T., Heatley, S., Nievergall, E., Kok, C., Dang, P., Yeung, D., . . . White, D. (2015). JAK2 MUTATIONS ARE HIGHLY ENRICHED IN CRLF2-REARRANGED B-ALL CASES WITH A PH-LIKE GENE SIGNATURE. Poster session presented at the meeting of HAEMATOLOGICA. Vienna, AUSTRIA: FERRATA STORTI FOUNDATION.
WoS12014 Nievergall, E., Heatley, S., Kok, C., Dang, P., Frede, A., Moore, S., . . . White, D. (2014). THE INCIDENCE OF THE HIGH-RISK PH-LIKE ALL SUBTYPE MAY ACCOUNT FOR THE MAJORITY OF NON BCR-ABL1+B ALL CASES IN ADULTS. Poster session presented at the meeting of HAEMATOLOGICA. Milan, ITALY: FERRATA STORTI FOUNDATION.
Grant Funding:
July 1 2016- June 30 2017 The Kids Cancer Project $170,932
Elucidating drug sensitivity and clonal evolution of Ph-like ALL in adolescents.
Fellowship: Susan Heatley
2015 Channel 7 Children’s Research Foundation $75,000
Developing a robust screening tool to identify children with high risk “Ph-like” Acute Lymphoblastic Leukaemia (ALL) that will lead to improved outcomes through the use of targeted therapies.
CIA Susan Heatley, CIB Deborah White, CIC Charles Mullighan
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2024 Co-Supervisor Identifying Predictors of CNS involvement in Acute Lymphoblastic Leukaemia Doctor of Philosophy Doctorate Full Time Mr Luke Jacob Quinlan 2023 Co-Supervisor Interrogating the DUX4 rearranged subtype of B cell Acute Lymphoblastic Leukaemia Doctor of Philosophy Doctorate Full Time Mr Thomas Oliver McGovern -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2018 - 2021 Co-Supervisor Exploring the cooperation and targetability of CRLF2 and HMGN1 in Down Syndrome Acute Lymphoblastic Leukaemia Doctor of Philosophy Doctorate Full Time Miss Elyse Chenae Page 2017 - 2021 Co-Supervisor Characterising the novel MYB-TYK2 fusion gene in high-risk acute lymphoblastic leukaemia: oncogenic potential, effective therapeutic strategies and In vitro modelling of drug resistance mechanisms Doctor of Philosophy Doctorate Full Time Miss Paniz Tavakoli Shirazi 2015 - 2018 Co-Supervisor In vitro Modelling of High-risk ALL Fusions Uncovers Genomic Alterations and Non-canonical Signalling Pathways as a Mode of TKI-Resistance - Implications for Targeted Therapy Doctor of Philosophy Doctorate Full Time Miss Kartini Asari
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