Stuart Pitson

Research Interests

Biochemistry and Cell Biology Cancer Cell Biology Cancer Therapy Haematological Tumours Solid Tumours

Prof Stuart Pitson

Research Professor

Centre for Cancer Biology

College of Health

Stuart obtained his PhD at La Trobe University, and subsequently undertook research positions at Wageningen University, The Netherlands, and then the University of New South Wales. He moved to Adelaide in 1998 and began his current research interests in examining cell signalling pathways controlled by sphingolipids, and how they contribute to cancer, viral infections, wound healing and other conditions. His research has primarily focused on the molecular mechanisms governing the sphingosine kinases, the pivotal enzymes controlling sphingolipid metabolism, determining how these are altered in disease, and approaches to target these to improve human health. His laboratory has made a number of important contributions to the field, including the cloning of the first human sphingosine kinase, and identification of key phosphorylations and protein interactions relating to the sphingosine kinases that have (patho)physiological significance, as well as the development of novel inhibitors with potential clinical application.

Date Institution name Country Title
1991 - 1995 La Trobe University Australia PhD
1987 - 1989 La Trobe University Australia BAppSc

Year Citation
2025 Price, Z. K., Lokman, N. A., Morrison, J., Mhlanga, S. N., Sugiyama, M., Koya, Y., . . . Ricciardelli, C. (2025). Identification of Sphingosine Kinase 1 as a Novel Protein Regulated by High Molecular Weight Hyaluronan in Ovarian Cancer.. J Cell Mol Med, 29(9), e70574.
DOI
2025 Manning, J. A., Jesudason, S., Moretti, P. A. B., Pitson, S. M., Chou, A. S. Y., Shabbar, M., . . . Kumar, S. (2025). Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice. Cell Death and Disease, 16(496), 1-23.
DOI Scopus1 WoS1 Europe PMC1
2025 Mekonnen, L. B., Teo, T., Noll, B., Rahaman, M. H., Lenjisa, J., Basnet, S., . . . Wang, S. (2025). A brain-penetrant CDK4/6 inhibitor - AU3-14 shows robust anti-tumor efficacy against glioblastoma.. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 189(118340), 118340.
DOI Europe PMC1
2025 Subramaniam, S., Donnellan, L., Wignall, A., Woodcock, J., Coolen, C., Pitson, S., . . . Joyce, P. (2025). Polymeric-lipid nanoparticles that leverage cationic helper lipids and the protein corona for lung-targeted delivery of a novel anti-cancer drug. Journal of Controlled Release, 388(Pt 1), 15 pages.
DOI
2025 Powell, J. A., & Pitson, S. M. (2025). Sphingosine 1-phosphate signalling in cancer stem cells. Oncogenesis, 14(1), 1-10.
DOI
2024 Li, M., Bennett, M. K., Toubia, J., Pope, V. S., Tea, M. N., Tamang, S., . . . Pitson, S. M. (2024). An orthotopic syngeneic mouse model of bortezomib-resistant multiple myeloma. British Journal of Haematology, 204(2), 566-570.
DOI Scopus1 WoS1 Europe PMC1
2024 Calabrese, C., Nolte, H., Pitman, M. R., Ganesan, R., Lampe, P., Laboy, R., . . . Robinson, N. (2024). Mitochondrial translocation of TFEB regulates complex I and inflammation.. EMBO Reports, 25(2), 704-724.
DOI Scopus9 WoS8 Europe PMC8
2024 Johan, M. Z., Pyne, N. T., Kolesnikoff, N., Poltavets, V., Esmaeili, Z., Woodcock, J. M., . . . Samuel, M. S. (2024). Accelerated Closure of Diabetic Wounds by Efficient Recruitment of Fibroblasts upon Inhibiting a 14-3-3/ROCK Regulatory Axis. The Journal of Investigative Dermatology, 144(11), 2562-2573.e4.
DOI Scopus1 WoS1 Europe PMC1
2024 Nwosu, G. O., Ross, D. M., Powell, J. A., & Pitson, S. M. (2024). Venetoclax therapy and emerging resistance mechanisms in acute myeloid leukaemia. Cell Death and Disease, 15(6, article no. 413), 413-1-413-11.
DOI Scopus27 WoS24 Europe PMC24
2024 Yu, W., Truong, N. T. H., Polara, R., Gargett, T., Tea, M. N., Pitson, S. M., . . . Brown, M. P. (2024). Endogenous bystander killing mechanisms enhance the activity of novel FAP‐specific CAR‐T cells against glioblastoma. Clinical & Translational Immunology, 13(7), e1519-1-e1519-20.
DOI Scopus10 WoS11 Europe PMC7
2024 Polara, R., Ganesan, R., Pitson, S. M., & Robinson, N. (2024). Cell autonomous functions of CD47 in regulating cellular plasticity and metabolic plasticity. Cell Death Differ, 31(10), 1255-1266.
DOI Scopus19 WoS20 Europe PMC13
2023 Conn, V. M., Gabryelska, M., Toubia, J., Kirk, K., Gantley, L., Powell, J. A., . . . Conn, S. J. (2023). Circular RNAs drive oncogenic chromosomal translocations within the MLL recombinome in leukemia. Cancer Cell, 41(7), 1309-1326.e10.
DOI Scopus51 WoS50 Europe PMC47
2023 Lazniewska, J., Li, K. L., Johnson, I. R. D., Sorvina, A., Logan, J. M., Martini, C., . . . Brooks, D. A. (2023). Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression. Scientific reports, 13(1, article no. 13489), 1-18.
DOI Scopus13 WoS12 Europe PMC10
2023 Subramanian, S., Thoms, J. A. I., Huang, Y., Cornejo Paramo, C. P., Koch, F. C., Jacquelin, S., . . . Pimanda, J. E. (2023). Genome-wide transcription factor-binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs. Blood, 142(17), 1448-1462.
DOI Scopus30 WoS30 Europe PMC40
2023 Yip, K. H., Chao, J., Coolen, C., Pant, H., Kral, A., Smith, W., . . . Tumes, D. J. (2023). IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3ζ. Journal of Allergy and Clinical Immunology, 152(3), 725-735.
DOI Scopus5 WoS5 Europe PMC3
2022 Nwosu, G. O., Powell, J. A., & Pitson, S. M. (2022). Targeting the integrated stress response in hematologic malignancies.. Experimental Hematology & Oncology, 11(1), 94.
DOI Scopus12 WoS14 Europe PMC13
2022 Bassal, M. A., Samaraweera, S. E., Lim, K., Bernard, B. A., Bailey, S., Kaur, S., . . . D'Andrea, R. J. (2022). Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia. Nature Communications, 13(1), 1-12.
DOI Scopus18 WoS19 Europe PMC16
2022 Mahabaleshwar, H., Asharani, P. V., Loo, T. Y., Koh, S. Y., Pitman, M. R., Kwok, S., . . . Carney, T. J. (2022). Slit-Robo signalling establishes a Sphingosine-1-phosphate gradient to polarise fin mesenchyme. EMBO reports, 23(8), 1-14.
DOI Scopus3 WoS3 Europe PMC6
2022 Bassal, M. A., Samaraweera, S. E., Lim, K., Benard, B. A., Bailey, S., Kaur, S., . . . D'Andrea, R. J. (2022). Author Correction: Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia.. Nat Commun, 13(1), 4131.
DOI Scopus2 WoS2 Europe PMC1
2022 Gargett, T., Ebert, L. M., Truong, N. T. H., Kollis, P. M., Sedivakova, K., Yu, W., . . . Brown, M. P. (2022). GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma. Journal for ImmunoTherapy of Cancer, 10(9), 1-15.
DOI Scopus79 WoS79 Europe PMC75
2022 Ebert, L. M., Vandyke, K., Johan, M. Z., DeNichilo, M., Tan, L. Y., Myo Min, K. K., . . . Bonder, C. S. (2022). Desmoglein-2 expression is an independent predictor of poor prognosis patients with multiple myeloma. Molecular Oncology, 16(6), 1221-1240.
DOI Scopus11 WoS12 Europe PMC11
2022 Pitman, M. R., Lewis, A. C., Davies, L. T., Moretti, P. A. B., Anderson, D., Creek, D. J., . . . Pitson, S. M. (2022). The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism. Scientific Reports, 12(1), 454-1-454-12.
DOI Scopus15 WoS13 Europe PMC12
2022 Gomez-Brouchet, A., Illac, C., Ledoux, A., Fortin, P. Y., de Barros, S., Vabre, C., . . . Cuvillier, O. (2022). Sphingosine Kinase-1 is Overexpressed and Correlates with Hypoxia in Osteosarcoma: Relationship with Clinicopathological Parameters. Cancers, 14(3), 499-1-499-17.
DOI Scopus4 WoS3 Europe PMC2
2022 Tvorogov, D., Thompson-Peach, C. A. L., Foßelteder, J., Dottore, M., Stomski, F., Onnesha, S. A., . . . Lopez, A. F. (2022). Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody. EMBO Reports, 23(4), e52904-1-e52904-12.
DOI Scopus22 WoS22 Europe PMC21
2022 Lewis, A. C., Pope, V. S., Tea, M. N., Li, M., Nwosu, G. O., Nguyen, T. M., . . . Pitson, S. M. (2022). Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia.. Blood, 139(26), 3737-3751.
DOI Scopus37 WoS32 Europe PMC35
2022 Kollis, P. M., Ebert, L. M., Toubia, J., Bastow, C. R., Ormsby, R. J., Poonnoose, S. I., . . . Gargett, T. (2022). Characterising Distinct Migratory Profiles of Infiltrating T-Cell Subsets in Human Glioblastoma. Frontiers in immunology, 13, 850226-1-850226-19.
DOI Scopus23 WoS21 Europe PMC18
2021 Mahabaleshwar, H., Asharani, P. V., Yi Jun, T. L., Koh, S. Y., Pitman, M., Kwok, S., . . . Carney, T. (2021). Slit-Robo Signalling Establishes a Sphingosine-1-Phosphate Gradient to Polarise Fin Mesenchyme and Establish Fin Morphology.
DOI
2021 Lewis, A. C., Wallington-Beddoe, C. T., Powell, J. A., & Pitson, S. M. (2021). Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies (vol 4, 72, 2018). CELL DEATH DISCOVERY, 7(1), 2 pages.
DOI
2021 Savira, F., Magaye, R., Scullino, C. V., Flynn, B. L., Pitson, S. M., Anderson, D., . . . Wang, B. H. (2021). Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition. Toxicology Letters, 350, 133-142.
DOI Scopus10 WoS11 Europe PMC10
2021 Savira, F., Kompa, A. R., Kelly, D. J., Magaye, R., Xiong, X., Huang, L., . . . Wang, B. H. (2021). The effect of dihydroceramide desaturase 1 inhibition on endothelial impairment induced by indoxyl sulfate. Vascular Pharmacology, 141(141, article no. 106923), 106923-1-106923-9.
DOI Scopus4 WoS4 Europe PMC4
2021 Bennett, M. K., Li, M., Tea, M. N., Pitman, M. R., Toubia, J., Wang, P. P. -S., . . . Pitson, S. M. (2021). Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition.. Neoplasia, 24(1), 1-11.
DOI Scopus16 WoS16 Europe PMC13
2021 Pitman, M., Oehler, M. K., & Pitson, S. M. (2021). Sphingolipids as multifaceted mediators in ovarian cancer. Cellular Signalling, 81(109949), 1-18.
DOI Scopus15 WoS15 Europe PMC15
2021 Duszyc, K., Gomez, G. A., Lagendijk, A. K., Yau, M. K., Nanavati, B. N., Gliddon, B. L., . . . Yap, A. S. (2021). Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion. Current Biology, 31(6), 1326-1336.
DOI Scopus47 WoS46 Europe PMC47
2021 Oksdath Mansilla, M., Salazar-Hernandez, C., Perrin, S. L., Scheer, K. G., Cildir, G., Toubia, J., . . . Gomez, G. A. (2021). 3D-printed microplate inserts for long term high-resolution imaging of live brain organoids. BMC biomedical engineering, 3(6), 1-14.
DOI Europe PMC17
2021 Lenin, S., Ponthier, E., Scheer, K. G., Yeo, E. C. F., Tea, M. N., Ebert, L. M., . . . Gomez, G. A. (2021). A drug screening pipeline using 2D and 3D patient-derived in vitro models for pre-clinical analysis of therapy response in glioblastoma. International Journal of Molecular Sciences, 22(9), 4322-1-4322-27.
DOI Scopus38 WoS37 Europe PMC35
2021 Pham, D. H., Pitman, M. R., Sharma, R., Jolly, L., Schulz, R., Gardner, A., . . . Gecz, J. (2021). Integrated in silico and experimental assessment of disease relevance of PCDH19 missense variants. Hum Mutat, 42(8), 1030-1041.
DOI Scopus1 WoS1 Europe PMC1
2020 Morrish, E., Copeland, A., Moujalled, D. M., Powell, J. A., Silke, N., Lin, A., . . . Brumatti, G. (2020). Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models. Blood Advances, 4(20), 5062-5077.
DOI Scopus10 WoS9 Europe PMC9
2020 Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., . . . Samuel, M. S. (2020). ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism. Nature Cell Biology, 22(7), 882-895.
DOI Scopus60 WoS60 Europe PMC56
2020 Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., . . . Samuel, M. S. (2020). Publisher Correction: ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.. Nat Cell Biol, 22(7), 908.
DOI Scopus5 WoS4 Europe PMC6
2020 Ebert, L. M., Yu, W., Gargett, T., Toubia, J., Kollis, P. M., Tea, M. N., . . . Brown, M. P. (2020). Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy. Clinical and Translational Immunology, 9(10), 1-24.
DOI Scopus51 WoS48 Europe PMC47
2020 Tea, M. N., Poonnoose, S. I., & Pitson, S. M. (2020). Targeting the sphingolipid system as a therapeutic direction for glioblastoma. Cancers, 12(1), 111-1-111-25.
DOI Scopus41 WoS40 Europe PMC35
2019 Al-Shujairi, W. H., Clarke, J. N., Davies, L. T., Pitman, M. R., Calvert, J. K., Aloia, A. L., . . . Carr, J. M. (2019). In vitro and in vivo roles of sphingosine kinase 2 during dengue virus infection. Journal of General Virology, 100(4), 629-641.
DOI Scopus12 WoS11 Europe PMC9
2019 Jiang, Z. J., Delaney, T. L., Zanin, M. P., Haberberger, R. V., Pitson, S. M., Huang, J., . . . Gong, L. W. (2019). Extracellular and intracellular sphingosine-1-phosphate distinctly regulates exocytosis in chromaffin cells. Journal of Neurochemistry, 149(6), 729-746.
DOI Scopus12 WoS11 Europe PMC11
2019 Bennett, M. K., Wallington-Beddoe, C. T., & Pitson, S. M. (2019). Sphingolipids and the unfolded protein response. BBA - Molecular and Cell Biology of Lipids, 1864(10), 1483-1494.
DOI Scopus28 WoS27 Europe PMC21
2019 Gachechiladze, M., Tichy, T., Kolek, V., Grygárková, I., Klein, J., Mgebrishvili, G., . . . Škarda, J. (2019). Sphingosine kinase-1 predicts overall survival outcomes in non-small cell lung cancer patients treated with carboplatin and navelbine. Oncology Letters, 18(2), 1259-1266.
DOI Scopus28 WoS25 Europe PMC25
2019 Powell, J. A., Pitman, M. R., Zebol, J. R., Moretti, P. A., Neubauer, H. A., Davies, L. T., . . . Pitson, S. M. (2019). Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1. The Biochemical Journal, 476(21), 3211-3226.
DOI Scopus14 WoS14 Europe PMC12
2019 Neubauer, H. A., Tea, M. N., Zebol, J. R., Gliddon, B. L., Stefanidis, C., Moretti, P. A. B., . . . Pitson, S. M. (2019). Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma. Oncogene, 38(8), 1151-1165.
DOI Scopus26 WoS24 Europe PMC18
2019 Wallington-Beddoe, C., Xie, V., Tong, D., Powell, J., Lewis, A., Davies, L., . . . Bendall, L. (2019). Identification of sphingosine kinase 1 as a therapeutic target in B-lineage acute lymphoblastic leukaemia. British Journal of Haematology, 184(3), 443-447.
DOI Scopus13 WoS13 Europe PMC13
2018 Wallington-Beddoe, C. T., Sobieraj-Teague, M., Kuss, B. J., & Pitson, S. M. (2018). Resistance to proteasome inhibitors and other targeted therapies in myeloma. British Journal of Haematology, 182(1), 11-28.
DOI Scopus90 WoS87 Europe PMC86
2018 Pitson, S. M., & Powell, J. A. (2018). Modification of the tumour microenvironment via exosomal shedding of sphingosine 1-phosphate receptor 2 by breast cancer cells. OncoTarget, 9(57), 30938-30939.
DOI Scopus2 Europe PMC2
2018 Lidgerwood, G. E., Pitson, S. M., Bonder, C., & Pébay, A. (2018). Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology. Progress in Lipid Research, 72, 42-54.
DOI Scopus34 WoS33 Europe PMC30
2018 Lewis, A. C., Wallington-Beddoe, C. T., Powell, J. A., & Pitson, S. M. (2018). Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies. Cell Death Discovery, 5(1), 4.
DOI Scopus63 WoS66 Europe PMC56
2018 Poltavets, V., Kochetkova, M., Pitson, S. M., & Samuel, M. S. (2018). The role of the extracellular matrix and its molecular and cellular regulators in cancer cell plasticity. Frontiers in Oncology, 8(431), 431-1-431-19.
DOI Scopus311 WoS301 Europe PMC267
2018 Woodcock, J., Goodwin, K., Sandow, J., Coolen, C., Perugini, M., Webb, A., . . . Carver, J. (2018). Role of salt bridges in the dimer interface of 14-3-3ζ in dimer dynamics, N-terminal α-helical order, and molecular chaperone activity. Journal of Biological Chemistry, 293(1), 89-99.
DOI Scopus23 WoS23 Europe PMC20
2017 Wallington-Beddoe, C., Bennett, M., Vandyke, K., Davies, L., Zebol, J., Moretti, P., . . . Pitson, S. (2017). Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress. Oncotarget, 8(27), 43602-43616.
DOI Scopus42 WoS40 Europe PMC36
2017 Zhu, W., Jarman, K., Lokman, N., Neubauer, H., Davies, L., Gliddon, B., . . . Pitson, S. (2017). CIB2 negatively regulates oncogenic signaling in ovarian cancer via sphingosine kinase 1. Cancer Research, 77(18), 4823-4834.
DOI Scopus30 WoS26 Europe PMC25
2017 Wallington Beddoe, C. T., & Pitson, S. M. (2017). Enhancing ER stress in myeloma. Aging, 9(7), 1645-1646.
DOI Scopus5 WoS5 Europe PMC5
2017 Aloia, A. L., Calvert, J. K., Clarke, J. N., Davies, L. T., Helbig, K. J., Pitson, S. M., & Carr, J. M. (2017). Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection. Clinical and Translational Immunology, 6(7), e151-1-e151-9.
DOI Scopus11 WoS10 Europe PMC10
2017 Wallington Beddoe, C. T., & Pitson, S. M. (2017). Novel therapies for multiple myeloma. Aging, 9(8), 1857-1858.
DOI Scopus4 WoS5 Europe PMC5
2017 Tran, H., Jersmann, H., Truong, T., Hamon, R., Roscioli, E., Ween, M., . . . Hodge, S. (2017). Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD. PLoS ONE, 12(11), e0179577-1-e0179577-14.
DOI Scopus30 WoS28 Europe PMC22
2017 Powell, J., Lewis, A., Zhu, W., Toubia, J., Pitman, M., Wallington-Beddoe, C., . . . Pitson, S. (2017). Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia.. Blood, 129(6), 771-782.
DOI Scopus86 WoS80 Europe PMC74
2017 Zhu, W., Gliddon, B., Jarman, K., Moretti, P., Tin, T., Parise, L., . . . Pitson, S. (2017). CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1. Oncogene, 36(18), 2619-2627.
DOI Scopus29 WoS27 Europe PMC19
2017 Al-Shujairi, W., Clarke, J., Davies, L., Alsharifi, M., Pitson, S., & Carr, J. (2017). Intracranial injection of dengue virus induces interferon stimulated genes and CD8⁺ T cell infiltration by sphingosine kinase 1 independent pathways. PLoS One, 12(1), 0169814-1-0169814-12.
DOI Scopus11 WoS11 Europe PMC9
2017 Rojas-Canales, D., Penko, D., Min, K., Parham, K., Peiris, H., Haberberger, R., . . . Jessup, C. (2017). Local sphingosine kinase 1 activity improves islet transplantation. Diabetes, 66(5), 1301-1311.
DOI Scopus7 WoS7 Europe PMC4
2017 Hein, N., Cameron, D., Hannan, K., Nguyen, N., Fong, C., Sornkom, J., . . . Hannan, R. (2017). Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population. Blood, 129(21), 2882-2895.
DOI Scopus72 WoS73 Europe PMC67
2017 Powell, J. A., Wallington Beddoe, C. T., & Pitson, S. M. (2017). Targeting sphingosine kinase 1 in acute myeloid leukemia: translation to clinic. International journal of hematologic oncology, 6(2), 31-34.
DOI Europe PMC6
2017 Etemadi, N., Chopin, M., Anderton, H., Tanzer, M. C., Rickard, J. A., Abeysekera, W., . . . Silke, J. (2017). Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.. eLife, 6, e29849.
DOI Scopus6 Europe PMC5
2017 Schoenwaelder, S., Darbousset, R., Cranmer, S., Ramshaw, H., Orive, S., Sturgeon, S., . . . Jackson, S. (2017). Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nature communications, 8(1), 16125.
DOI Scopus1 WoS1
2017 Powell, J. A., Lewis, A. C., & Pitson, S. M. (2017). The MCL-1 inhibitor S63845: an exciting new addition to the armoury of anti-cancer agents. Journal of Xiangya Medicine, 2(6), 53.
DOI Scopus3
2016 McNaughton, M., Pitman, M., Pitson, S. M., Pyne, N. J., & Pyne, S. (2016). Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells. Oncotarget, 7(13), 16663-16675.
DOI Scopus67 WoS64 Europe PMC60
2016 Sun, W. Y., Dimasi, D. P., Pitman, M. R., Zhuang, Y., Heddle, R., Pitson, S. M., . . . Bonder, C. S. (2016). Topical application of fingolimod perturbs cutaneous inflammation. Journal of Immunology, 196(9), 3854-3864.
DOI Scopus14 WoS13 Europe PMC14
2016 Neubauer, H. A., & Pitson, S. M. (2016). Validation of commercially available sphingosine kinase 2 antibodies for use in immunoblotting, immunoprecipitation and immunofluorescence. F1000Research, 5(article no. 2825), 1-12.
DOI Scopus4 Europe PMC4
2016 Clarke, J., Davies, L., Calvert, J., Gliddon, B., Al Shujari, W., Aloia, A., . . . Carr, J. (2016). Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses. Journal of General Virology, 97(1), 95-109.
DOI Scopus20 WoS17 Europe PMC17
2016 Tran, H. B., Barnawi, J., Ween, M., Hamon, R., Roscioli, E., Hodge, G., . . . Hodge, S. (2016). Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720. Journal of Leukocyte Biology, 100(1), 195-202.
DOI Scopus29 WoS29 Europe PMC26
2016 Dimasi, D., Pitson, S., & Bonder, C. (2016). Examining the role of sphingosine kinase-2 in the regulation of endothelial cell barrier integrity. Microcirculation, 23(3), 248-265.
DOI Scopus11 WoS9 Europe PMC10
2016 Aurelio, L., Scullino, C. V., Pitman, M. R., Sexton, A., Oliver, V., Davies, L., . . . Flynn, B. L. (2016). From sphingosine kinase to dihydroceramide desaturase: a structure-activity relationship (SAR) study of the enzyme inhibitory and anticancer activity of 4-((4-(4-chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II). Journal of Medicinal Chemistry, 59(3), 965-984.
DOI Scopus58 WoS53 Europe PMC38
2016 Pitman, M. R., Costabile, M., & Pitson, S. M. (2016). Recent advances in the development of sphingosine kinase inhibitors. Cellular Signalling, 28(9), 1349-1363.
DOI Scopus84 WoS85 Europe PMC69
2016 Neubauer, H. A., Pham, D. H., Zebol, J. R., Moretti, P. A. B., Peterson, A. L., Leclercq, T. M., . . . Pitson, S. M. (2016). An oncogenic role for sphingosine kinase 2. Oncotarget, 7(40), 64886-64899.
DOI Scopus54 WoS50 Europe PMC52
2016 Schoenwaelder, S. M., Darbousset, R., Cranmer, S. L., Ramshaw, H. S., Orive, S. L., Sturgeon, S., . . . Jackson, S. P. (2016). 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nature Communications, 7(12862), 12862-1-12862-15.
DOI Scopus55 WoS53 Europe PMC47
2015 Kular, J., Scheer, K., Pyne, N., Allam, A., Pollard, A., Magenau, A., . . . Samuel, M. (2015). A negative regulatory mechanism involving 14-3-3ζ limits signaling downstream of ROCK to regulate tissue stiffness in epidermal homeostasis. Developmental Cell, 35(6), 759-774.
DOI Scopus30 WoS24 Europe PMC27
2015 Etemadi, N., Chopin, M., Anderton, H., Tanzer, M., Rickard, J., Abeysekera, W., . . . Silke, J. (2015). TRAF2 regulates TNF and NF-kB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. eLife, 4(e10592), e10592-1-e10592-27.
DOI Scopus89 WoS86 Europe PMC76
2015 Woodcock, J., Coolen, C., Goodwin, K., Baek, D., Bittman, R., Samuel, M., . . . Lopez, A. (2015). Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics. Oncotarget, 6(16), 14522-14536.
DOI Scopus34 WoS30 Europe PMC25
2015 Parham, K., Zebol, J., Tooley, K., Sun, W., Moldenhauer, L., Cockshell, M., . . . Bonder, C. (2015). Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis. The FASEB Journal, 29(9), 3638-3653.
DOI Scopus82 WoS77 Europe PMC70
2015 Bonder, C. S., & Pitson, S. M. (2015). Sphingolipids: who's controlling who in disease?. Immunology and Cell Biology, 93(9), 767-768.
DOI Scopus2 WoS2 Europe PMC2
2015 Canlas, J., Holt, P., Carroll, A., Rix, S., Ryan, P., Davies, L., . . . Haberberger, R. (2015). Sphingosine kinase 2-deficiency mediated changes in spinal pain processing. Frontiers in Molecular Neuroscience, 8(29), 1-13.
DOI Scopus17 WoS18 Europe PMC13
2015 Aloia, A., Abraham, A., Bonder, C., Pitson, S., & Carr, J. (2015). Dengue virus-induced inflammation of the endothelium and the potential roles of sphingosine kinase-1 and microRNAs. Mediators of Inflammation, 2015(509306), 509306-1-509306-13.
DOI Scopus23 WoS23 Europe PMC17
2015 Barnawi, J., Hai, T., Jersmann, H., Pitson, S., Roscioli, E., Hodge, G., . . . Hodge, S. (2015). Potential link between the Sphingosine-1-Phosphate (S1P) system and defective alveolar macrophage phagocytic function in Chronic Obstructive Pulmonary Disease (COPD). PLoS One, 10(10), e0122771-1-e0122771-21.
DOI Scopus50 WoS44 Europe PMC43
2015 Pitman, M., Powell, J., Coolen, C., Moretti, P., Zebol, J., Pham, D., . . . Pitson, S. (2015). A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget, 6(9), 7065-7083.
DOI Scopus65 WoS64 Europe PMC56
2015 Calvert, J., Helbig, K., Dimasi, D., Cockshell, M., Beard, M., Pitson, S., . . . Carr, J. (2015). Dengue virus infection of primary endothelial cells induces innate immune responses, changes in endothelial cells function and is restricted by interferon-stimulated responses. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 35(8), 654-665.
DOI Scopus32 WoS29 Europe PMC26
2015 Beroukas, D., Selhorst, M., Pitson, S. M., Matusica, D., Gibbins, I. L., Kress, M., & Haberberger, R. V. (2015). Sphingosine kinase 1 in murine dorsal root ganglia. AIMS Molecular Science, 2(1), 22-33.
DOI WoS1
2014 Dhagat, U., Woodcock, J., Tiong, C., Holien, J., Coolen, C., Broughton, S., . . . Parker, M. (2014). Structural studies on 14-3-3z: compounds that target the dimer interface. Acta Crystallographica Section A: Foundations and Advances, 70(C808), 808.
DOI
2014 Parham, K. A., Pitson, S. M., & Bonder, C. S. (2014). Regulation of EPCs: The Gateway to Blood Vessel Formation. New journal of science, 2014(972043), 1-16.
DOI
2014 Wallington-Beddoe, C., Powell, J., Tong, D., Pitson, S., Bradstock, K., & Bendall, L. (2014). Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression. Cancer Research, 74(10), 2803-2815.
DOI Scopus71 WoS65 Europe PMC63
2014 Yamane, D., McGivern, D., Wauthier, E., Yi, M., Madden, V., Welsch, C., . . . Lemon, S. (2014). Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation. Nature Medicine, 20(8), 927-935.
DOI Scopus134 WoS124 Europe PMC125
2014 Pham, D., Powell, J., Gliddon, B., Moretti, P., Tsykin, A., Van der Hoek, M., . . . Pitson, S. (2014). Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1. Oncogene, 33(48), 5559-5568.
DOI Scopus26 WoS25 Europe PMC23
2014 Holt, P., Barnawi, J., Hodge, G., Jermann, H., Reynolds, P., Pitson, S., . . . Hodge, S. (2014). IMPAIRMENT OF EFFEROCYTOSIS BY CIGARETTE SMOKE CAN BE REVERSED IN THP-1 MACROPHAGES BY STIMULATION WITH SPHINGOSINE-1-PHOSPHATE. RESPIROLOGY, 19, 47.
2014 Ceccom, J., Loukh, N., Lauwers, C. V., Touriol, C., Nicaise, Y., Gentil, C., . . . Delisle, M. B. (2014). Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease. Acta neuropathologica communications, 2(1), 1-10.
DOI Scopus116 WoS116 Europe PMC104
2013 Wallington Beddoe, C., Pitson, S., Bradstock, K., & Bendall, L. (2013). Targeting sphingosine kinase 2 suppresses MYC expression and kills acute lymphoblastic leukemia cells. Experimental Hematology, 41(8), 49.
DOI
2013 Neubauer, H., & Pitson, S. (2013). Roles, regulation and inhibitors of sphingosine kinase 2. FEBS Journal, 280(21), 5317-5336.
DOI Scopus146 WoS139 Europe PMC122
2013 Carr, J., Kua, T., Clarke, J., Calvert, J., Zebol, J., Beard, M., & Pitson, S. (2013). Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3' untranslated region of dengue virus type-2 RNA. Journal of General Virology, 94(11), 2437-2448.
DOI Scopus30 WoS30 Europe PMC29
2013 Thomas, D., Powell, J., Green, B., Barry, E., Ma, Y., Woodcock, J., . . . Guthridge, M. (2013). Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. PLoS Biology, 11(3), 1-14.
DOI Scopus20 WoS17 Europe PMC21
2013 Chan, H., & Pitson, S. (2013). Post-translational regulation of sphingosine kinases. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1831(1), 147-156.
DOI Scopus32 WoS33 Europe PMC28
2013 Powell, J., Pitman, M., Coolen, C., Zhu, W., Lewis, I., D'Andrea, R., . . . Lopez, A. (2013). Targeting sphingosine kinase as a therapy for acute myeloid leukaemia. Experimental Hematology, 41(8), S54.
DOI
2013 Carr, J., Mahalingam, S., Bonder, C., & Pitson, S. (2013). Sphingosine kinase 1 in viral infections. Reviews in Medical Virology, 23(2), 73-84.
DOI Scopus44 WoS42 Europe PMC37
2012 Pitman, M., Woodcock, J., Lopez, A., & Pitson, S. (2012). Molecular targets of FTY720 (Fingolimod). Current Molecular Medicine, 12(10), 1207-1219.
DOI Scopus62 WoS59 Europe PMC57
2012 Bruce, C., Risis, S., Babb, J., Yang, C., Kowalski, G., Selathurai, A., . . . Febbraio, M. (2012). Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice. Diabetes, 61(12), 3148-3155.
DOI Scopus128 WoS125 Europe PMC114
2012 Lim, K., Tonelli, F., Berdyshev, E., Gorshkova, I., Leclercq, T., Pitson, S., . . . Pyne, N. (2012). Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b. International Journal of Biochemistry & Cell Biology, 44(9), 1457-1464.
DOI Scopus33 WoS32 Europe PMC31
2012 Pitman, M., Pham, D., & Pitson, S. (2012). Isoform-selective assays for sphingosine kinase activity. Methods in molecular biology, 874, 21-31.
DOI Scopus32 Europe PMC26
2012 Sun, W., Abeynaike, L., Escarbe, S., Smith, C., Pitson, S., Hickey, M., & Bonder, C. (2012). Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent. American Journal of Pathology, 180(4), 1740-1750.
DOI Scopus23 WoS24 Europe PMC22
2012 Hercus, T., Broughton, S., Ekert, P., Ramshaw, H., Perugini, M., Grimbaldeston, M., . . . Lopez, A. (2012). The GM-CSF receptor family: mechanism of activation and implications for disease. Growth Factors, 30(2), 63-75.
DOI Scopus63 WoS59 Europe PMC54
2012 Juarez, J., Harun, N., Thien, M., Welschinger, R., Baraz, R., Dela Pena, A., . . . Bendall, L. (2012). Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. Blood, 119(3), 707-716.
DOI Scopus126 WoS115 Europe PMC113
2011 Jessup, C., Bonder, C., Pitson, S., & Coates, P. (2011). The sphingolipid rheostat: A potential target for improving pancreatic islet survival and function. Endocrine, Metabolic & Immune Disorders - Drug Targets, 11(4), 262-272.
DOI Scopus29 Europe PMC28
2011 Cordts, F., Pitson, S., Tabeling, C., Gibbins, I., Moffat, D., Jersmann, H., . . . Haberberger, R. (2011). Expression profile of the sphingosine kinase signalling system in the lung of patients with chronic obstructive pulmonary disease. Life Sciences, 89(21-22), 806-811.
DOI Scopus28 WoS25 Europe PMC26
2011 Barrett, J., Parham, K., Pippal, J., Cockshell, M., Moretti, P., Brice, S., . . . Bonder, C. (2011). Over-expression of sphingosine kinase-1 enhances a progenitor phenotype in human endothelial cells. Microcirculation, 18(7), 583-597.
DOI Scopus10 WoS10 Europe PMC9
2011 Pchejetski, D., Nunes, J., Coughlan, K., Lall, H., Pitson, S., Waxman, J., & Sumbayev, V. (2011). The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1a protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6. Immunology and Cell Biology, 89(2), 268-274.
DOI Scopus54 WoS55 Europe PMC50
2011 Siow, D., Anderson, C., Berdyshev, E., Skobeleva, A., Natarajan, V., Pitson, S., & Wattenberg, B. (2011). Sphingosine kinase localization in the control of sphingolipid metabolism. Advances in Enzyme Regulation, 51(1), 229-244.
DOI Scopus31 WoS27 Europe PMC29
2011 Leclercq, T., Moretti, P., & Pitson, S. (2011). Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis. Oncogene, 30(3), 372-378.
DOI Scopus47 WoS39 Europe PMC36
2011 Pitson, S., Powell, J., & Bonder, C. (2011). Regulation of sphingosine kinase in hematological malignancies and other cancers. Anti-Cancer Agents in Medicinal Chemistry, 11(9), 799-809.
DOI Scopus22 WoS22 Europe PMC19
2011 Wati, S., Rawlinson, S., Ivanov, R., Dorstyn, L., Beard, M., Jans, D., . . . Carr, J. (2011). Tumour necrosis factor alpha (TNF-α) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-α to activate nuclear factor κB and reduced sphingosine kinase-1 activity. Journal of General Virology, 92(4), 807-818.
DOI Scopus46 WoS46 Europe PMC43
2011 Pitman, M., Barr, R., Gliddon, B., Magarey, A., Moretti, P., & Pitson, S. (2011). A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1. International Journal of Biochemistry & Cell Biology, 43(3), 342-347.
DOI Scopus23 WoS18 Europe PMC20
2011 Pitson, S. (2011). Regulation of sphingosine kinase and sphingolipid signaling. Trends in Biochemical Sciences, 36(2), 97-107.
DOI Scopus276 WoS260 Europe PMC233
2011 Xia, P., Wang, L., Moretti, P. A. B., Albanese, N., Chai, F., Pitson, S. M., . . . Vadas, M. A. (2011). Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-α signaling. Journal of Biological Chemistry, 286(11), 9894.
DOI
2011 Xia, P., Wang, L., Moretti, P. A. B., Albanese, N., Chai, F., Pitson, S. M., . . . Vadas, M. A. (2011). Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-α signaling (Journal of Biological Chemistry (2002) 227, (7996-8003)). Journal of Biological Chemistry, 286(49), 42785.
DOI
2010 Malavaud, B., Pchejetski, D., Mazerolles, C., Silva Russano de Paiva, G., Clavet, C., Doumerc, N., . . . Cuvillier, O. (2010). 107 Increased sphingosine kinase-1 activity and expression in prostate cancer. Journal of Urology, 183(4), e44.
DOI
2010 Malavaud, B., Pchejetski, D., Mazerolles, C., de Paiva, G. R., Calvet, C., Doumerc, N., . . . Cuvillier, O. (2010). Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens. European Journal of Cancer, 46(18), 3417-3424.
DOI Scopus81 WoS76 Europe PMC67
2010 Tonelli, F., Loveridge, C., Leclercq, T., Lim, K., Long, J., Berdyshev, E., . . . Pyne, S. (2010). The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells. Journal of Biological Chemistry, 285(50), 38841-38852.
DOI Scopus108 WoS102 Europe PMC92
2010 Williams, S., Milne, I., Bagley, C., Gamble, J., Vadas, M., Pitson, S., & Khew-Goodall, Y. (2010). A proinflammatory role for proteolytically cleaved annexin A1 in neutrophil transendothelial migration. Journal of Immunology, 185(5), 3057-3063.
DOI Scopus77 WoS73 Europe PMC66
2010 Siow, D., Anderson, C., Berdyshev, E., Skobeleva, A., Pitson, S., & Wattenberg, B. (2010). Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate. Journal of Lipid Research, 51(9), 2546-2559.
DOI Scopus39 WoS37 Europe PMC37
2010 Sun, W., Pitson, S., & Bonder, C. (2010). Tumor necrosis factor-induced neutrophil adhesion occurs via sphingosine kinase-1-dependent activation of endothelial α₅β₁ integrin. American Journal of Pathology, 177(1), 436-446.
DOI Scopus32 WoS30 Europe PMC28
2010 Jarman, K., Moretti, P., Zebol, J., & Pitson, S. (2010). Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1. Journal of Biological Chemistry, 285(1), 483-492.
DOI Scopus127 WoS115 Europe PMC106
2010 Woodcock, J., Ma, Y., Coolen, C., Pham, D., Jones, C., Lopez, A., & Pitson, S. (2010). Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function. Cellular Signalling, 22(9), 1291-1299.
DOI Scopus65 WoS63 Europe PMC61
2010 Pitman, M., & Pitson, S. (2010). Inhibitors of the sphingosine kinase pathway as potential therapeutics. Current Cancer Drug Targets, 10(4), 354-367.
DOI Scopus71 WoS69 Europe PMC56
2010 Tonelli, F., Lim, K., Loveridge, C., Long, J., Pitson, S., Tigyi, G., . . . Pyne, N. (2010). FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cellular Signalling, 22(10), 1536-1542.
DOI Scopus168 WoS159 Europe PMC152
2010 Song, J., Kim, M., Park, S., Chen, S., Pitson, S., & Lee, H. (2010). Isoflurane via TGF-β1 release increases caveolae formation and organizes sphingosine kinase signaling in renal proximal tubules. American Journal of Physiology: Renal Physiology, 298(4), F1041-F1050.
DOI Scopus25 WoS24 Europe PMC22
2010 Kim, M., Kim, M., Park, S., Pitson, S., & Lee, H. (2010). Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation. American Journal of Nephrology, 31(4), 353-362.
DOI Scopus50 WoS49 Europe PMC45
2010 Pitman, M. R., & Pitson, S. M. (2010). Inhibitors of the Sphingosine Kinase Pathway as Potential Therapeutics. Current Cancer Drug Targets, 999(999), 1-14.
DOI
2009 Gamble, J., Sun, W., Li, X., Hahn, C., Pitson, S., Vadas, M., & Bonder, C. (2009). Sphingosine kinase-1 associates with Integrin alpha(V)beta(3) to mediate endothelial cell survival. American Journal of Pathology, 175(5), 2217-2225.
DOI Scopus17 WoS14 Europe PMC14
2009 Pitson, S., & Pebay, A. (2009). Regulation of stem cell pluripotency and neural differentiation by lysophospholipids. NeuroSignals (Print), 17(4), 242-254.
DOI Scopus56 WoS44 Europe PMC41
2009 Lidington, D., Peter, B., Meissner, A., Kroetsch, J., Pitson, S., Pohl, U., & Bolz, S. (2009). The Phosphorylation Motif at Serine 225 Governs the Localization and Function of Sphingosine Kinase 1 in Resistance Arteries. Arteriosclerosis Thrombosis and Vascular Biology, 29(11), 1916-1928.
DOI Scopus27 WoS26 Europe PMC24
2009 Limaye, V., Vadas, M., Pitson, S., & Gamble, J. (2009). The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells. Cellular & Molecular Biology Letters, 14(3), 411-423.
DOI Scopus7 WoS7 Europe PMC6
2009 Limaye, V., Xia, P., Hahn, C., Smith, M., Vadas, M., Pitson, S., & Gamble, J. (2009). Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells. Cellular & Molecular Biology Letters, 14(3), 424-441.
DOI Scopus35 WoS25 Europe PMC20
2009 ter Braak, M., Danneberg, K., Lichte, K., Liphardt, K., Ktistakis, N., Pitson, S., . . . Meyer zu Heringdorf, D. (2009). G alpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1791(5), 357-370.
DOI Scopus30 WoS30 Europe PMC29
2009 Bonder, C., Sun, W., Matthews, T., Cassano, C., Li, X., Ramshaw, H., . . . Gamble, J. (2009). Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood, 113(9), 2108-2117.
DOI Scopus39 WoS37 Europe PMC34
2009 Zebol, J., Hewitt, N., Moretti, P., Lynn, H., Lake, J., Li, P., . . . Pitson, S. (2009). The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1. International Journal of Biochemistry & Cell Biology, 41(4), 822-827.
DOI Scopus18 WoS16 Europe PMC15
2008 Pitson, S., Goodall, G., & Guthridge, M. (2008). Science amongst the vines - Meeting on signalling systems. EMBO Reports, 9(5), 425-428.
DOI
2008 Leclercq, T., Moretti, P., Vadas, M., & Pitson, S. (2008). Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity. Journal of Biological Chemistry, 283(15), 9606-9614.
DOI Scopus48 WoS46 Europe PMC45
2008 Li, X., Stankovic, M., Bonder, C., Hahn, C., Parsons, M., Pitson, S., . . . Gamble, J. (2008). Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. Blood, 111(7), 3489-3497.
DOI Scopus77 WoS70 Europe PMC61
2008 Pham, D., Moretti, P., Goodall, G., & Pitson, S. (2008). Attenuation of leakiness in doxycycline-inducible expression via incorporation of 3 ' AU-rich mRNA destabilizing elements. Biotechniques, 45(2), 155-162.
DOI Scopus20 WoS18 Europe PMC19
2008 Barr, R., Lynn, H., Moretti, P., Khew-Goodall, Y., & Pitson, S. (2008). Deactivation of Sphingosine Kinase 1 by Protein Phosphatase 2A. Journal of Biological Chemistry, 283(50), 34994-35002.
DOI Scopus51 WoS43 Europe PMC42
2008 Kusner, D. J., Thompson, C. R., Melrose, N. A., Pitson, S. M., Obeid, L. M., & Iyer, S. S. (2008). The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages (Journal of Biological Chemistry (2007) 282, (23147-23162)). Journal of Biological Chemistry, 283(9), 5972.
Scopus1
2008 Kusner, D. J., Thompson, C. R., Melrose, N. A., Pitson, S. M., Obeid, L. M., & Iyer, S. S. (2008). The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages (vol 282, pg 23147, 2007). JOURNAL OF BIOLOGICAL CHEMISTRY, 283(9), 5972.
WoS1
2008 Pham, D., Moretti, P., Goodall, G., & Pitson, S. (2008). Attenuation of leakiness in doxycycline-inducible expression via incorporation of 3' AU-rich mRNA destabilizing elements. BioTechniques: the journal of laboratory technology for bioresearch, 155(2), 45-162.
2007 Pebay, A., Bonder, C., & Pitson, S. (2007). Stem cell regulation by lysophospholipids. Prostaglandins & Other Lipid Mediators, 84(3-4), 83-97.
DOI Scopus96 WoS89 Europe PMC70
2007 Kusner, D., Thompson, C., Melrose, N., Pitson, S., Obeid, L., & Iyer, S. (2007). The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages. Journal of Biological Chemistry, 282(32), 23147-23162.
DOI Scopus28 WoS24 Europe PMC26
2007 Soldi, R., Mandinova, A., Venkataraman, K., Hla, T., Vadas, M., Pitson, S., . . . Prudovsky, I. (2007). Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Experimental Cell Research, 313(15), 3308-3318.
DOI Scopus24 WoS22 Europe PMC22
2006 Leclercq, T., & Pitson, S. (2006). Cellular signalling by sphingosine kinase and sphingosine 1-phosphate. IUBMB Life, 58(8), 467-472.
DOI Scopus56 WoS51 Europe PMC41
2006 Pitson, S. (2006). Lipids as central mediators of cellular signalling. IUBMB Life, 58(8), 449.
DOI Scopus1 WoS1
2006 Wattenberg, B., Pitson, S., & Raben, D. (2006). The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function. Journal of Lipid Research, 47(6), 1128-1139.
DOI Scopus116 WoS114 Europe PMC95
2006 Keller, M., Lidington, D., Vogel, L., Peter, B., Sohn, H., Pagano, P., . . . Bolz, S. (2006). Sphingosine kinase functionally links elevated transmural pressure and increased reactive oxygen species formation in resistance arteries. FASEB Journal, 20(6), 1-20.
DOI Scopus51 WoS52 Europe PMC45
2006 O'Halloran, C., Moretti, P., Hewitt, N., Bagley, C., Vadas, M., & Pitson, S. (2006). The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane. Journal of Biological Chemistry, 281(17), 11693-11701.
DOI Scopus66 WoS62 Europe PMC52
2005 Pitson, S., Xia, P., Leclercq, T., Moretti, P., Zebol, J., Lynn, H., . . . Vadas, M. (2005). Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling. Journal of Experimental Medicine, 201(1), 49-54.
DOI Scopus239 WoS229 Europe PMC214
2005 Pebay, A., Wong, R., Pitson, S., Wolvetang, E., Peh, G., Filipczyk, A., . . . Pera, M. (2005). Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells. Stem Cells, 23(10), 1541-1548.
DOI Scopus169 WoS139 Europe PMC126
2005 Ma, Y., Pitson, S., Hercus, T., Murphy, J., Lopez, A., & Woodcock, J. (2005). Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. Journal of Biological Chemistry, 280(28), 26011-26017.
DOI Scopus66 WoS61 Europe PMC51
2005 Blom, T., Slotte, J., Pitson, S., & Tornquist, K. (2005). Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilisation in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response. Cellular Signalling, 17(7), 827-836.
DOI Scopus36 WoS34 Europe PMC32
2005 Thompson, C., Iyer, S., Melrose, N., VanOosten, R., Johnson, K., Pitson, S., . . . Kusner, D. (2005). Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: Inhibition of SK1 translocation by Mycobacterium tuberculosis. Journal of Immunology, 174(6), 3551-3561.
DOI Scopus95 WoS83 Europe PMC71
2004 Roberts, J., Moretti, P., Darrow, A., Derian, C., Vadas, M., & Pitson, S. (2004). An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes. Analytical Biochemistry, 331(1), 122-129.
DOI Scopus37 WoS34 Europe PMC29
2004 Roberts, J. L., Moretti, P. A. B., Darrow, A. L., Derian, C. K., Vadas, M. A., & Pitson, S. M. (2004). An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes. Analytical Biochemistry, 331(1), 122-129.
DOI
2003 Waters, C., Sambi, B., Kong, K., Thompson, D., Pitson, S., Pyne, S., & Pyne, N. (2003). Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGFb receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells. Journal of Biological Chemistry, 278(8), 6282-6290.
DOI Scopus124 WoS120 Europe PMC107
2003 Stein, B., Gamble, J., Pitson, S., Vadas, M., & Khew-Goodall, Y. (2003). Activation of endothelial extracellular signal-regulated kinase is essential for neutrophil transmigration: Potential involvement of a soluble neutrophil factor in endothelial activation. Journal of Immunology, 171(11), 6097-6104.
DOI Scopus27 WoS25 Europe PMC21
2003 Pitson, S., Moretti, P., Zebol, J., Lynn, H., Xia, P., Vadas, M., & Wattenberg, B. (2003). Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. EMBO Journal, 22(20), 5491-5500.
DOI Scopus496 WoS476 Europe PMC428
2003 Sukocheva, O., Wang, L., Albanese, N., Pitson, S., Vadas, M., & Xia, P. (2003). Sphingosine kinase transmits estrogen signaling in human breast cancer cells. Molecular Endocrinology, 17(10), 2002-2012.
DOI Scopus142 WoS135 Europe PMC118
2003 Bolz, S. S., Vogel, L., Sollinger, D., Derwand, R., Boer, C., Pitson, S. M., . . . Pohl, U. (2003). Sphingosine kinase modulates microvascular tone and myogenic responses through activation of Rhoa/Rho kinase. Circulation, 108(3), 342-347.
DOI Scopus126 WoS117 Europe PMC108
2002 Pitson, S., Moretti, P., Zebol, J., Zareie, R., Derian, C., Darrow, A., . . . Wattenberg, B. (2002). The nucleotide-binding site of human sphingosine kinase 1. Journal of Biological Chemistry, 277(51), 49545-49553.
DOI Scopus98 WoS94 Europe PMC81
2002 Xia, P., Wang, L., Moretti, P., Albanese, N., Chai, F., Pitson, S., . . . Vadas, M. (2002). Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-a signaling. Journal of Biological Chemistry, 277(10), 7996-8003.
DOI Scopus282 WoS261 Europe PMC237
2001 Pitson, S., Moretti, P., Zebol, J., Vadas, M., D'Andrea, R., & Wattenberg, B. (2001). A point mutant of human sphingosine kinase 1 with increased catalytic activity. FEBS Letters, 509(2), 169-173.
DOI Scopus16 WoS16 Europe PMC15
2000 Xia, P., Gamble, J., Wang, L., Pitson, S., Moretti, P., Wattenberg, B., . . . Vadas, M. (2000). An oncogenic role of sphingosine kinase. Current Biology, 10(23), 1527-1530.
DOI Scopus364 WoS337 Europe PMC307
2000 Pitson, S., D'Andrea, R., Vandeleur, L., Moretti, P., Xia, P., Gamble, J., . . . Wattenberg, B. (2000). Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes. Biochemical Journal, 350(2), 429-441.
DOI Scopus166 WoS158 Europe PMC146
2000 Pitson, S., Moretti, P., Zebol, J., Xia, P., Gamble, J., Vadas, M., . . . Wattenberg, B. (2000). Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. Journal of Biological Chemistry, 275(43), 33945-33950.
DOI Scopus173 WoS172 Europe PMC149
2000 PITSON, S. M., D’ANDREA, R. J., VANDELEUR, L., MORETTI, P. A. B., XIA, P., GAMBLE, J. R., . . . WATTENBERG, B. W. (2000). Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes. Biochemical Journal, 350(2), 429.
DOI
1999 Van Laere, K. M. J., Hartemink, R., Beldman, G., Pitson, S., Dijkema, C., Schols, H. A., & Voragen, A. G. J. (1999). Transglycosidase activity of Bifidobacterium adolescentis DSM 20083 α- galactosidase. Applied Microbiology and Biotechnology, 52(5), 681-688.
DOI Scopus55 WoS51 Europe PMC32
1999 Pitson, S. M., Seviour, R. J., & McDougall, B. M. (1999). Induction and carbon source control of extracellular β-glucosidase production in Acremonium persicinum. Mycological Research, 103(2), 161-167.
DOI Scopus6 WoS5 Europe PMC2
1999 Pitson, S. M., Seviour, R. J., & McDougall, B. M. (1999). Intracellular and cell wall associated β-glucanases and β-glucosidases of Acremonium persicinum. Mycological Research, 103(10), 1217-1224.
DOI Scopus1 WoS1 Europe PMC1
1999 Pitson, S. M., Mendz, G. L., Srinivasan, S., & Hazell, S. L. (1999). The tricarboxylic acid cycle of Helicobacter pylori. European Journal of Biochemistry, 260(1), 258-267.
DOI Scopus76 WoS74 Europe PMC62
1998 Mutter, M., Beldman, G., Pitson, S. M., Schols, H. A., & Voragen, A. G. J. (1998). Rhamnogalacturonan α-D-galactopyranosyluronohydrolase: An enzyme that specifically removes the terminal nonreducing galacturonosyl residue in rhamnogalacturonan regions of pectin. Plant Physiology, 117(1), 153-163.
DOI Scopus53 WoS40 Europe PMC28
1998 Pitson, S. M., Mutter, M., Van Den Broek, L. A. M., Voragen, A. G. J., & Beldman, G. (1998). Stereochemical course of hydrolysis catalysed by α-L-rhamnosyl and α-D-galacturonosyl hydrolases from Aspergillus aculeatus. Biochemical and Biophysical Research Communications, 242(3), 552-559.
DOI Scopus25 WoS23 Europe PMC20
1997 Pitson, S. M., Seviour, R. J., & McDougall, B. M. (1997). Purification and characterization of an extracellular β-glucosidase from the filamentous fungus Acremonium persicinum and its probable role in β-glucan degradation. Enzyme and Microbial Technology, 21(3), 182-190.
DOI Scopus53 WoS43 Europe PMC27
1997 Pitson, S. M., Voragen, A. G. J., Vincken, J. P., & Beldman, G. (1997). Action patterns and mapping of the substrate-binding regions of endo-(1 → 5)-α-L-arabinanases from Aspergillus niger and Aspergillus aculeatus. Carbohydrate Research, 303(2), 207-218.
DOI Scopus21 WoS20 Europe PMC18
1997 Pitson, S. M., Seviour, R. J., & McDougall, B. M. (1997). Effect of carbon source on extracellular and (1→3)- and (1→6)-β- glucanase production by Acremonium persicinum. Canadian Journal of Microbiology, 43(5), 432-439.
DOI Scopus24 WoS21
1997 Pitson, S. M., Seviour, R. J., & McDougall, B. M. (1997). Production of β-glucan degrading enzymes by Acremonium and Cephalosporium species. Mycological Research, 101(2), 153-158.
DOI Scopus13 WoS13 Europe PMC8
1996 Pitson, S. M., Seviour, R. J., & McDougall, B. M. (1996). Proteolytic inactivation of an extracellular (1→3)-β-glucanase from the fungus Acremonium persicinum is associated with growth at neutral or alkaline medium pH. FEMS Microbiology Letters, 145(2), 287-293.
DOI Scopus9 WoS7 Europe PMC4
1996 Pitson, S. M., Voragen, A. G. J., & Beldman, G. (1996). Stereochemical course of hydrolysis catalyzed by arabinofuranosyl hydrolases. FEBS Letters, 398(1), 7-11.
DOI Scopus57 WoS56 Europe PMC45
1996 Pitson, S. M., Seviour, R. J., McDougall, B. M., Stone, B. A., & Sadek, M. (1996). Purification and characterization of an extracellular (1 → 6)-β-glucanase from the filamentous fungus Acremonium persicinum. Biochemical Journal, 316(3), 841-846.
DOI Scopus37 WoS33 Europe PMC24
1995 Pitson, S. M., Seviour, R. J., McDougall, B. M., Woodward, J. R., & Stone, B. A. (1995). Purification and characterization of three extracellular (1→3)-β-D-glucan glucohydrolases from the filamentous fungus Acremonium persicinum. Biochemical Journal, 308(3), 733-741.
DOI Scopus31 WoS31 Europe PMC20
1993 Pitson, S. M., Seviour, R. J., & McDougall, B. M. (1993). Noncellulolytic fungal β-glucanases: Their physiology and regulation. Enzyme and Microbial Technology, 15(3), 178-192.
DOI Scopus155 WoS147 Europe PMC88
1991 Pitson, S., Seviour, R. J., Bott, J., & Stasinopoulos, S. J. (1991). Production and regulation of β-glucanases in Acremonium and Cephalosporium isolates. Mycological Research, 95(3), 352-356.
DOI Scopus28 WoS27 Europe PMC12
- Neubauer, H. A., & Pitson, S. M. (2017). Validation of commercially available sphingosine kinase 2 antibodies for use in immunoblotting, immunoprecipitation and immunofluorescence. F1000Research, 5, 2825.
DOI

Year Citation
2017 Pitman, M., Davies, L., & Pitson, S. (2017). An improved isoform-selective assay for sphingosine kinase 1 activity. In Source details - Title: Sphingosine-1-Phosphate (Vol. 1697, pp. 9-20). US: Humana Press, Inc..
DOI Scopus3 Europe PMC3
2017 Lewis, A. C., Powell, J. A., & Pitson, S. M. (2017). The Emerging Role of Sphingolipids in Cancer Stem Cell Biology. In Stem Cell Biology and Regenerative Medicine (Vol. Part F4899, pp. 151-170). Springer International Publishing.
DOI Scopus1
2013 Pitman, M., Jarman, K., Leclercq, T., Pham, D., & Pitson, S. (2013). Sphingosine Kinases: Biochemistry, Regulation, and Roles. In J. Chun, T. Hla, W. Moolenaar, & S. Spiegel (Eds.), Lysophospholipid Receptors: Signaling and Biochemistry (pp. 153-183). Hoboken, New Jersey; USA: Wiley.
DOI Scopus1
1997 Beldman, G., Schols, H. A., Pitson, S. M., Searle-van Leeuwen, M. J. F., & Voragen, A. G. J. (1997). Arabinans and arabinan degrading enzymes. In Advances in Macromolecular Carbohydrate Research (pp. 1-64). Elsevier.
DOI

Year Citation
2023 Hamon, R., Jiang, X., Coolen, C., Lopez, A., Reynolds, P., Pitson, S., & Woodcock, J. (2023). Dysregulated 14-3-3 expression in lung adenocarcinoma supports oncogenic signalling. In RESPIROLOGY Vol. 28 (pp. 56). WILEY.
2022 Hamon, R., Jiang, X., Toubia, J., Coolen, C., Lopez, A., Reynolds, P. N., . . . Woodcock, J. (2022). Dysregulation of 14-3-3 Signaling Adapters in Lung Adenocarcinoma, New Insights Into the Impact on Cancer Cell Biology. In JOURNAL OF THORACIC ONCOLOGY Vol. 17 (pp. S618-S619). ELSEVIER SCIENCE INC.
2020 Hamon, R., Coolen, C., Reynolds, P., Pitson, S., & Woodcock, J. (2020). PROFILING OF 14-3-3 PROTEIN ISOFORM EXPRESSION IN NON-SMALL CELL LUNG CANCER. In RESPIROLOGY Vol. 25 (pp. 174). WILEY.
2019 Hamon, R., Coolen, C., Reynolds, P., Pitson, S., & Woodcock, J. (2019). Effect of 14-3-3 protein induction on oncogenic potential of BEAS-2B bronchial epithelial cells. In EUROPEAN RESPIRATORY JOURNAL Vol. 54 (pp. 2 pages). Madrid, SPAIN: EUROPEAN RESPIRATORY SOC JOURNALS LTD.
DOI
2018 Yip, K. H., Woodcock, J., Pitson, S., & Lopez, A. (2018). Establishing the potential of a sphingosine mimetic, RB-011, as an inhibitor of allergic diseases. In ALLERGY Vol. 73 (pp. 163). Munich, GERMANY: WILEY.
2017 Lewis, A. C., D'Andrea, R., Powell, J. A., & Pitson, S. M. (2017). Dual Sphingosine Kinase and Bcl-2 Inhibition Exhibits Synergistic Cell Death in Acute Myeloid Leukemia. In BLOOD Vol. 130 (pp. 2 pages). Atlanta, GA: AMER SOC HEMATOLOGY.
2016 Wang, B., Aurelio, L., Wang, I., Scullino, C., Hua, Y., Pitson, S. M., . . . Flynn, B. L. (2016). Sphingolipid targeting agent MIPS247 attenuates collagen synthesis by cardiac and kidney cells via stabilization of PPM1A. In EUROPEAN HEART JOURNAL Vol. 37 (pp. 912). Rome, ITALY: OXFORD UNIV PRESS.
2016 Pham, D., Kolc, K. L., Schulz, R., Corbett, M., Gardner, A., Pitson, S., . . . Gecz, J. (2016). In vitro and in silico assessment of PCDH19 variation. In Human Epilepsy - Understanding biology to improve outcomes. Vibe Hotel, Marysville VIC.
2015 Rojas-Canales, D., Penko, D., Peiris, H., Keating, D., Pitson, S., Drogemuller, C. J., . . . Jessup, C. J. (2015). SPHINGOSINE KINASE 1 IS VITAL FOR THE FUNCTION OF ISLETS POST TRANSPLANTATION.. In TRANSPLANTATION Vol. 99 (pp. S225). Melbourne, AUSTRALIA: LIPPINCOTT WILLIAMS & WILKINS.
2015 Rojas-Canales, D., Penko, D., Peiris, H., Keating, D., Pitson, S., Drogemuller, C. J., . . . Jessup, C. J. (2015). Sphingosine kinase 1 is vital for the function of islets post transplantation. In XENOTRANSPLANTATION Vol. 22 (pp. S136). Melbourne, AUSTRALIA: WILEY-BLACKWELL.
2014 Delisle, M. B., Ceccom, J., Loukh, N., Lauwers-Cances, V., Touriol, C., Nicaise, Y., . . . Cuvillier, O. (2014). Sphingolipids deregulation in Alzheimer's disease. In BRAIN PATHOLOGY Vol. 24 (pp. 43). Rio de Janeiro, BRAZIL: WILEY-BLACKWELL.
2013 Axcrona, U., Vlatkovic, L., Saeter, T., Servoll, E., Waaler, G., Mazerolles, C., . . . Cuvillier, O. (2013). Sphingosine kinase-1 expression is associated with prostate cancer specific mortality: A potential new prognostic biomarker?. In VIRCHOWS ARCHIV Vol. 463 (pp. 345-346). SPRINGER.
2012 Sun, W. Y., Abeynaik, L., Pitson, S., Hickey, M., & Bonder, C. (2012). SPHINGOSINE KINASE-1 REGULATES P-SELECTIN EXPRESSION AND NEUTROPHIL RECRUITMENT DURING ALLERGIC INFLAMMATION. In INTERNAL MEDICINE JOURNAL Vol. 42 (pp. 12-13). WILEY-BLACKWELL.
2010 Lidington, D., Peter, B. F., Meissner, A., Kroetsch, J., Pitson, S., Pohl, U., & Bolz, S. -S. (2010). Serine 225 phosphorylation governs the localization and function of sphingosine kinase 1 in resistance arteries. In FASEB JOURNAL Vol. 24 (pp. 1 page). FEDERATION AMER SOC EXP BIOL.
2010 Wattenberg, B., Siow, D., Berdyshev, E., Pitson, S., & Anderson, C. (2010). Sphingosine kinase-1 compartmentalization drives downstream metabolism of sphingosine-1-phosphate and upstream metabolism of ceramide biosynthesis. In FASEB JOURNAL Vol. 24 (pp. 1 page). FEDERATION AMER SOC EXP BIOL.
2010 Malavaud, B., Pchejetski, D., Mazerolles, C., Silva, R. D. P. G., Calvet, C., Doumerc, D., . . . Cuvillier, O. (2010). INCREASED SPHINGOSINE KINASE-1 ACTIVITY AND EXPRESSION IN PROSTATE CANCER. In EUROPEAN UROLOGY SUPPLEMENTS Vol. 9 (pp. 277). ELSEVIER SCIENCE BV.
DOI
2008 Malavaud, B., Pchejetski, D., mazerolles, C., Calvet, C., Doumerc, N., Pitson, S., . . . Cuvillier, O. (2008). Correlation between sphingosine kinase-1 oncogene activity and the tumoral grade of prostatic tissues removed from radical prostatectomy. In BULLETIN DU CANCER Vol. 95 (pp. S20-S21). JOHN LIBBEY EUROTEXT LTD.
2006 Lidington, D., Peter, B. F., Pitson, S., Pohl, U., & Bolz, S. S. (2006). The microvascular effects of sphingosine kinase 1 are regulated by its subcellular localization. In FASEB JOURNAL Vol. 20 (pp. A301). San Francisco, CA: FEDERATION AMER SOC EXP BIOL.
2006 Scherer, E. Q., Lidington, D., Peter, B. F., Pitson, S., Arnold, W., Pohl, U., & Bolz, S. S. (2006). TNFα modulates spiral modiolar artery tone via regulation of the endogenous sphingosine kinase 1. In FASEB JOURNAL Vol. 20 (pp. A269). San Francisco, CA: FEDERATION AMER SOC EXP BIOL.
2006 Lidington, D., Peter, B. F., Pitson, S., Pohl, U., & Bolz, S. S. (2006). Forced localization of sphingosine kinase to the plasma membrane is not sufficient to impart regulatory function. In JOURNAL OF VASCULAR RESEARCH Vol. 43 (pp. 48). Rostock, GERMANY: KARGER.
2006 Guthridge, M. A., Goodall, G. J., & Pitson, S. M. (2006). Meeting report: Barossa 2005--Signaling Networks.. In Science S Stke Signal Transduction Knowledge Environment Vol. 2006 (pp. pe9). United States: American Association for the Advancement of Science (AAAS).
DOI Scopus1 Europe PMC2
2004 Bolz, S. S., Pitson, S., Spiegel, S., & Pohl, U. (2004). Sphingosine kinase (Sphk1) modulates tone and myogenic responses (MR) in isolated resistance arteries (RA) via activation of RhoA/Rho kinase. In FASEB JOURNAL Vol. 18 (pp. A307-A308). Washington, DC: FEDERATION AMER SOC EXP BIOL.
WoS1
2002 Bolz, S. S., Vogel, L., Sollinger, D., Derwand, R., Maximilians, L., Boer, C., . . . Pohl, U. (2002). Transfection of sphingosine kinase into vascular smooth muscle cells of isolated resistance arteries increases myogenic tone via activation of the RhoA/Rho kinase pathway. In CIRCULATION Vol. 106 (pp. 271). CHICAGO, ILLINOIS: LIPPINCOTT WILLIAMS & WILKINS.
2002 Bolz, S. S., Vogel, L., Sollinger, D., Derwand, R., Pitson, S., & Pohl, U. (2002). Transfection of sphingosine kinase in resistance arteries (RA) increases myogenic tone via activation of the RhoA/Rho kinase pathway. In FASEB JOURNAL Vol. 16 (pp. A1119). FEDERATION AMER SOC EXP BIOL.
2002 Limaye, V. S., Xia, P., Moretti, P., Pitson, S., Parsons, M., Vadas, M., & Gamble, J. (2002). Sphingosine kinase: A novel mediator of inflammatory arthritis. In ARTHRITIS AND RHEUMATISM Vol. 46 (pp. S33). LA, NEW ORLEANS: WILEY.

Year Citation
2022 Subramanian, S., Thoms, J. A. I., Huang, Y., Jacquelin, S., Powell, J., Pitson, S. M., & Pimanda, J. E. (2022). Comparative analysis of genome-scale gene regulatory networks in human hematopoietic stem and myeloid progenitor fractions. Poster session presented at the meeting of Blood. US: American Society of Hematology.
DOI
2019 Hamon, R., Coolen, C., Reynolds, P. N., Pitson, S. M., & Woodcock, J. (2019). Increased Expression of 14-3-3 Proteins in Lung Epithelial Cells: A Potential Role in the Development of Lung Cancer. Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. TX, Dallas: AMER THORACIC SOC.
2019 Hamon, R., Coolen, C., Reynolds, P., Pitson, S., & Woodcock, J. (2019). POTENTIAL ONCOGENIC ROLE FOR 14-3-3 PROTEINS IN LUNG CANCER INITIATION. Poster session presented at the meeting of RESPIROLOGY. WILEY.
2017 Hodge, S., Tran, H. B., Jersmann, H., Tung, T. T., Hamon, R., Roscioli, E., . . . Reynolds, P. N. (2017). Differential expression of the S1P transporter, Spinster homologue 2 (Spns2), in airway epithelial cells and macrophages may drive defective macrophage function in COPD. Poster session presented at the meeting of EUROPEAN RESPIRATORY JOURNAL. Milan, ITALY: EUROPEAN RESPIRATORY SOC JOURNALS LTD.
DOI
2016 Tran, H., Rhys, H., Ween, M., Hodge, G., Barnawi, J., Reynolds, P., . . . Hodge, S. (2016). SPNS2 IN THE AIRWAY EPITHELIAL CELLS AND ALVEOLAR MACROPHAGES CONTRIBUTES DIFFERENTLY INTO CIGARETTE-NDUCED DEREGULATED S1P SIGNALING: A TRANSLATION TO THE MECHANISM OF COPD. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL.
2016 Tran, H., Barnawi, J., Ween, M., Hamon, R., Roscioli, E., Hodge, G., . . . Hodge, S. (2016). CHANGED INTRACELLULAR LOCALIZATION OF SPHINGOSINE KINASES BY CIGARETTE SMOKE IN MACROPHAGES MAY CONTRIBUTE TO DEFECTIVE PHAGOCYTIC FUNCTION. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL.
2016 Tran, H., Hamon, R., Ween, M., Hodge, G., Roscioli, E., Barnawi, J., . . . Hodge, S. (2016). DIFFERENTIAL SUBCELLULAR LOCALIZATION AND EXPRESSION OF SPINSTER HOMOLOG 2 (DROSOPHILA) IN AIRWAY EPITHELIAL CELLS AND MACROPHAGES IN RESPONSE TO CIGARETTE SMOKE AND IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE MAY CONTRIBUTE TO MACROPHAGE PHAGOCYTIC DYSFUNCTION. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL.
2016 Rojas-Canales, D., Penko, D., Peiris, H., Pitson, S., Drogemuller, C., Keating, D., . . . Jessup, C. F. (2016). Sphingosine-1-phosphate promotes the migration of intraislet vascular cells: implications for post-transplant islet function. Poster session presented at the meeting of TRANSPLANTATION. LIPPINCOTT WILLIAMS & WILKINS.
2015 Carroll, A., Rix, S., Tran, H., Barnawi, J., Hodge, G., Pitson, S., . . . Hodge, S. (2015). PULMONARY MACROPHAGE EFFEROCYTOSIS IN COPD IS SUPPRESSED BY DISTURBANCES TO FEEDBACK MECHANISMS IN SPHINGOSINE 1 PHOSPHATE SIGNALLING AND REVERSED WITH FTY720. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL.
2015 Barnawi, J., Jersmann, H., Tran, H., Pitson, S., Haberberger, R., Meech, R., & Hodge, S. (2015). DIFFERENTIAL DNA METHYLATION PATTERN OF SPHINGOSINE-1 PHOSPHATE RECEPTOR 5 IN ALVEOLAR MACROPHAGES IN COPD - POTENTIAL LINK TO FAILED EFFEROCYTOSIS?. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL.
2014 Barnawi, J., Holt, P., Hodge, G., Jersmann, H., Pitson, S., Haberberger, R., & Hodge, S. (2014). THERAPEUTIC MODULATION OF THE SPHINGOSINE SIGNALLING SYSTEM WITH THYMOQUININE AS A NOVEL MACROPHAGE-TARGETED TREATMENT FOR COPD. Poster session presented at the meeting of Respirology. WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: Wiley.
DOI
2014 Sun, W. Y., Zhuang, Y., Dimasi, D., Pitson, S., Grimbaldeston, M., Heddle, R., & Bonder, C. (2014). EPICUTANEOUS APPLICATION OF FINGOLIMOD ATTENUATES ALLERGIC INFLAMMATION. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL.
2013 Wallington-Beddoe, C. T., Pitson, S. M., Powell, J. A., Bradstock, K. F., & Bendall, L. J. (2013). Evaluation Of Sphingosine Kinase 1 As a Therapeutic Target In B-Lineage Acute Lymphoblastic Leukemia. Poster session presented at the meeting of BLOOD. New Orleans, LA: AMER SOC HEMATOLOGY.
DOI
2012 Wallington-Beddoe, C. T., Bradstock, K. F., & Bendall, L. J. (2012). Identification of Sphingosine Kinases As Therapeutic Targets in B-Lineage Acute Lymphoblastic Leukemia. Poster session presented at the meeting of BLOOD. GA, Atlanta: AMER SOC HEMATOLOGY.
DOI WoS2
2012 Gliddon, B. L., Chan, H., & Pitson, S. M. (2012). SPHINGOSINE KINASE, SPHINGOSINE-1-PHOSPHATE, AND WOUND CONTRACTION. Poster session presented at the meeting of WOUND REPAIR AND REGENERATION. WILEY-BLACKWELL.

Year Citation
2016 Woodcock, J., Lopez, A., Pitson, S., Samuel, M., & Coolen, C. (2016). WO2016054680, Modulators of 14-3-3 functionality and uses thereof.

Year Citation
2025 Hein, N., Poh, P., Núñez Villacís, L., Sant’Anna Maranhão, S., Evers, M., Sornkom, J., . . . Ferreira, R. (2025). Novel RNA Polymerase I and Cyclin Dependent Kinase combination therapy for the treatment of aggressive Acute Myeloid Leukemia.
DOI
2025 Gardam, B., Nam, E., Kollis, P. M., Kilyen-Coles, J., Lenin, S., Gliddon, B. L., . . . Gargett, T. (2025). A Characterization of the Immune Cells in Immunocompetent and Immunodeficient Mice with Orthotopic Brain Tumors.
DOI Europe PMC1
2023 Subramanian, S., Subramanian, S., Thoms, J. A. I., Huang, Y., Cornejo, P., Koch, F., . . . Pimanda, J. (2023). Cell Type-Specific Regulation by a Heptad of Transcription Factors in Human Hematopoietic Stem and Progenitor Cells.
DOI
2023 Lazniewska, J., Li, K. L., Johnson, I., Sorvina, A., Logan, J., Martini, C., . . . Brooks, D. (2023). Dynamic interplay between sortilin and syndecan-1 drives a metabolic switch during prostate cancer progression.
DOI
2023 Calabrese, C., Nolte, H., Pitman, M., Ganesan, R., Lampe, P., Laboy, R., . . . Robinson, N. (2023). Mitochondrial translocation of TFEB regulates complex I and inflammation.
DOI
2023 Yu, W., Truong, N. T. H., Polara, R., Gargett, T., Tea, M., Pitson, S., . . . Brown, M. (2023). Endogenous bystander killing mechanisms enhance the activity of novel FAP-specific CAR-T cells against glioblastoma.
DOI
2022 Gargett, T., Ebert, L., Truong, N. T. H., Kollis, P., Sedivakova, K., Yu, W., . . . Brown, M. (2022). GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma.
DOI

  • Supporting Australian Brain Cancer Research with an integrated network of platforms, Medical Research Future Fund, 01/07/2023 - 30/06/2028

  • Drug Target Identification Platform, Medical Research Future Fund, 30/06/2023 - 29/06/2028

  • Overcoming the blood-brain barrier for improved brain tumour therapy, Fay Fuller Foundation, 01/07/2024 - 30/06/2027

  • Uncovering mutations predisposing children to brain cancer, Neurosurgical Research Foundation, 01/04/2025 - 30/06/2027

  • Developing personalised medicine approaches for glioblastoma therapy, Neurosurgical Research Foundation, 03/02/2025 - 03/03/2027

  • South Australian Paediatric Brain Cancer Bank, Neurosurgical Research Foundation, 01/01/2024 - 31/12/2026

  • Understanding therapy-induced glioblastoma evolution to overcome treatment resistance, Neurosurgical Research Foundation, 01/01/2026 - 31/12/2026

  • Examining sphingosine kinase 2 as a therapeutic target in diffuse midline glioma, Neurosurgical Research Foundation, 08/10/2025 - 31/12/2026

  • Targeting a common genetic alteration in glioblastoma, Neurosurgical Research Foundation, 16/09/2024 - 15/09/2026

  • Novel Drug Treatment for Fibrotic Disease, Australia's Economic Accelerator Ignite Grant, 20/06/2025 - 19/06/2026

  • Combined targeting of CD47 and cysteine metabolism to treat glioblastoma, Neurosurgical Research Foundation, 01/10/2024 - 31/03/2026

  • Bioengineering a Superior Humanized Haematopoietic Niche Derived from Mesenchymal Stem Cells for Pre-Clinical Avatar Cancer Trials, MRFF-Stem Cell Therapies Mission, 01/08/2023 - 31/01/2026

  • Understanding the biology of treatment resistant brain tumours so that new therapeutic approaches can be developed, Neurosurgical Research Foundation, 04/07/2024 - 31/12/2025

  • A new therapeutic approach for glioblastoma, Brain Foundation - Annual Research Awards, 01/01/2025 - 31/12/2025

  • Targeting sphingosine kinase 1 as a novel therapeutic strategy in childhood medulloblastoma, Neurosurgical Research Foundation, 01/10/2024 - 30/09/2025

  • Pre-clinical evaluation of sphingosine kinase 2 inhibitors as new glioblastoma therapeutics, Neurosurgical Research Foundation, 01/10/2024 - 30/09/2025

  • Targeting genetic defects in glioblastoma, Neurosurgical Research Foundation, 15/09/2024 - 12/09/2025

  • Targeting sphingolipid metabolism in disease, NHMRC - Senior Principal Research Fellowship, 01/01/2019 - 31/12/2023

  • A new therapeutic target for proteasome inhibitor resistant multiple myeloma, NHMRC - Project Grant, 01/01/2019 - 31/12/2022

  • Developing clinically relevant models of recurrent glioblastoma, Neurosurgical Research Foundation, 30/08/2021 - 31/08/2022

  • Inhibiting ER-stress induced CD47 to treat Glioblastoma, Neurosurgical Research Foundation, 30/08/2021 - 31/08/2022

  • Dihydroceramide Desaturase-1 (Des1) Inhibitors for the Treatment of Fibrotic Disease, NHMRC - Development Grant, 01/01/2019 - 12/12/2021

  • Targeting cyclin-dependent kinase 4 in glioblastoma, Neurosurgical Research Foundation, 24/08/2020 - 21/08/2021

  • Identification and targeting of the master regulators of glioma cancer cell plasticity to overcome therapy resistance in glioblastoma., Neurosurgical Research Foundation, 24/08/2020 - 21/08/2021

  • Targeting Sphingolipid Metabolism in Acute Myeloid Leukaemia Project, The Hospital Research Foundation, 01/04/2018 - 31/03/2021

  • Targeting sphingosine kinase 1 to sensitise acute myeloid leukaemia to BH3 mimetic therapy, NHMRC - Project Grant, 01/01/2018 - 31/12/2020

  • Central Adelaide Local Health Network Incorporated Scholarship, Central Adelaide Local Health Network Incorporated, 01/01/2016 - 02/03/2020

  • Modulating sphingolipid signalling to enhance wound healing, NHMRC - Project Grant, 01/01/2017 - 31/12/2019

  • Investigating the role of 14-3-3ζ in medulloblastoma, Neurosurgical Research Foundation, 01/01/2018 - 31/03/2019

  • Stereotactic alignment and injection system for the generation of xenografts of human brain tumours into the brains of mice for pre-clinical testing of new and existing therapeutics, Neurosurgical Research Foundation, 01/01/2018 - 31/12/2018

  • Defining the mechanisms regulating tissue mechano-reciprocity in wound healing, NHMRC - Project Grant, 01/01/2016 - 31/12/2018

  • Sphingosine kinase as a target for anti-cancer therapy, NHMRC - Research Fellowship, 01/01/2014 - 31/12/2018

  • Cancer Discovery Accelerator, Australian Cancer Research Foundation, 01/06/2016 - 31/07/2018

  • Central Adelaide Local Health Network Incorporated Scholarship, Central Adelaide Local Health Network Incorporated, 01/01/2016 - 31/03/2018

  • Defining the role of a palmitoylated variant of sphingosine kinase 1 in cancer, NHMRC - Project Grant, 01/01/2015 - 31/12/2017

  • Targeting sphingosine kinases to improve glioblastoma therapy, Neurosurgical Research Foundation, 21/06/2016 - 30/09/2017

  • Targeting Sphingosine Kinase 1C Degradation to Enhance Chemosensitivity', Central Adelaide Local Health Network Incorporated, 01/01/2016 - 30/06/2017

  • Cancer Discovery Accelerator, Cancer Council SA - Beat Cancer, 08/06/2016 - 08/06/2017

  • Liquid handling robot and cell analysis systems, Neurosurgical Research Foundation, 17/10/2016 - 30/05/2017

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Principal Supervisor A new therapeutic approach for the childhood brain tumour diffuse midline glioma Master of Philosophy Master Full Time Mr Ca Dat Pham
2025 Co-Supervisor Investigating the role of dihydroceramide desaturase in the brain using zebrafish Doctor of Philosophy Doctorate Full Time Mr Anqi Wang
2025 Co-Supervisor Validating sphingolipid pathway targets in ovarian cancer for therapeutic intervention Doctor of Philosophy Doctorate Full Time Mr Thomas Andrew Lymburn
2025 Co-Supervisor Investigating the role of dihydroceramide desaturase in the brain using zebrafish Doctor of Philosophy Doctorate Full Time Mr Anqi Wang
2025 Principal Supervisor - Doctor of Philosophy Doctorate Full Time Sarmad Khan
2025 Co-Supervisor - Doctor of Philosophy Doctorate Full Time Mr Ming Phong
2025 Co-Supervisor Validating sphingolipid pathway targets in ovarian cancer for therapeutic intervention Doctor of Philosophy Doctorate Full Time Mr Thomas Andrew Lymburn
2025 Principal Supervisor A new therapeutic approach for the childhood brain tumour diffuse midline glioma Master of Philosophy Master Full Time Mr Ca Dat Pham
2025 Co-Supervisor - Doctor of Philosophy Doctorate Full Time Ms Saumya Bansal
2025 Co-Supervisor - Doctor of Philosophy Doctorate Full Time Mr Rafaqat Hussain Haidari
2023 Principal Supervisor - Doctor of Philosophy Doctorate Full Time Ms Leeann Nicole Desouza
2022 Co-Supervisor - Doctor of Philosophy Doctorate Full Time Mr Chris Nam
2018 Principal Supervisor - Doctor of Philosophy Doctorate Full Time Mr Rhys Hamon

Date Role Research Topic Program Degree Type Student Load Student Name
2022 - 2025 Co-Supervisor Investigating Lipid Metabolism and Gene Expression in High Grade Serous Ovarian Cancer (HGSOC) Disease Progression and Chemoresistance Master of Philosophy Master Full Time Miss Nicola Sian Louisa Jones
2012 - 2017 Principal Supervisor Roles and Regulation of Sphingosine Kinase 2 in Cancer Doctor of Philosophy Doctorate Part Time Heidi Anne Neubauer
2012 - 2018 Principal Supervisor Regulation of Sphingosine Kinase 1 Oncogenic Signalling by Calcium and Integrin Binding Proteins Doctor of Philosophy Doctorate Part Time Ms Wenying Zhu
2010 - 2015 Co-Supervisor Sphingosine Kinase-1 Regulates Neutrophil Recruitment During Allergic Inflammation Doctor of Philosophy Doctorate Full Time Miss Wai Yan Sun
2010 - 2015 Principal Supervisor The Role of Sphingosine Kinases and SKAM1 in Cutaneous Wound Healing Doctor of Philosophy Doctorate Full Time Mr Huasheng Chan
2006 - 2010 Principal Supervisor Regulation of Sphingosine Kinase 1 Signalling by Calcium- and Integrin-binding Proteins Doctor of Philosophy Doctorate Full Time Ms Kate Jarman
2006 - 2012 Principal Supervisor Gene Regulation by Sphingosine Kinase Doctor of Philosophy Doctorate Full Time Dr Duyen Pham
2005 - 2010 Principal Supervisor Regulation of Sphingosine Kinase by Interacting Proteins Doctor of Philosophy Doctorate Full Time Dr Tamara Leclercq
2004 - 2009 Co-Supervisor A Novel Proinflammatory Role for Annexin A1 in Neutrophil Transendothelial Migration Doctor of Philosophy Doctorate Full Time Ms Samantha Louise Williams

Date Role Board name Institution name Country
2020 - ongoing Member NeuroSurgical Research Foundation NeuroSurgical Research Foundation Australia

Date Role Committee Institution Country
2025 - ongoing Member Cure Brain Cancer Foundation Scientific Advisory Committee Cure Brain Cancer Foundation Australia
2021 - ongoing Director Brain Tumour Research SA Executive Committee Brain Tumour Research SA Australia
2014 - ongoing Treasurer National Association of Research Fellows Executive Committee National Association of Research Fellows Australia

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