Stuart Brierley

Research Interests

Neuroscience, Behaviour and Brain Health Innovative Therapeutics

Prof Stuart Brierley

School of Pharmacy and Biomedical Science

College of Health

Professor Stuart Brierley is Director of the Visceral Pain Research Group, Director of the Hopwood Centre for Neurobiology, and Co-Theme Leader of Lifelong Health at the South Australian Health and Medical Research Institute (SAHMRI). He is an NHMRC Investigator L1 recipient (2022-2026), and received an NHMRC Research Excellence Award for being the top-ranked NHMRC CDF-II Fellow in the 2016 round.
 
Since 2020 he has been named in the Stanford University / Elsevier World Top 2% Scientist Rankings. He was also a South Australian Tall Poppy Science Awardee in 2011.
 
Professor Brierley is an international expert on the 'gut-brain axis' and chronic visceral pain mechanisms. His research comprises discovery and translational science investigating the nerve pathways innervating visceral organs to determine the causes of, and treatments for, Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD), bladder pain syndrome, and endometriosis. His research focuses on the role of different nerve pathways innervating the viscera, the channels and receptors underlying their function, the influence of microbiome and the immune system, and how these mechanisms are changed during acute and chronic visceral pain.
 
Professor Brierley has a proven track record of publishing innovative, technically demanding research in the fields of gastroenterology, pain, neuroscience and pharmacology. He has published 132 papers in high impact journals, such as Nature (x5), Science, Cell, Nature Communications, Gastroenterology (x6), Gut (x11), PNAS (x2), JCI Insight (x3), Pain (x13), J Neuroscience (x2). He also has invited reviews inNature Reviews Gastroenterology Hepatology (x2), Annual Reviews of Physiology. Since 2020 he has been named in the Stanford University / Elsevier Top 2% World Scientist Rankings.
 
Professor Brierley has been awarded >$43.5M in research funding (since 2004) including NHMRC fellowships (x4), NHMRC Project grants (x13), NHMRC Development grant (x1), NHMRC Synergy grant (x1), NIH RO1 grant (x1), NIH HEAL/SPARC grants (x2), MRFF (x1), ARC Discovery (x2) and ARC LIEF (x3).
 
Professor Brierley has a strong track record of industry collaboration. His collaborations with industry partners Ironwood Pharmaceuticals identified the mechanism of pain relief of a new drug (Linaclotide) in treating patients with IBS with constipation (IBS-C). Linaclotide, a guanylate cyclase-C agonist is effective in relieving abdominal pain associated with IBS-C and is available and registered for use by IBS-C patients in the USA, Europe, Asia, and Australia.
 
Professor Brierley has active collaborations with AusHealth, GSK, Nxera, Thetis, and Escient Pharmaceuticals for testing and developing novel visceral pain treatments. Over the last 10 years he has worked with Ironwood, Takeda, Ferring, Allergan, Arena, Sosei Heptares, Nocion, Zealand, and Tioga Pharmaceuticals.
 
For a current list of publications see:
https://www.ncbi.nlm.nih.gov/pubmed/?term=brierley-sm.
 
Key Positions:
 
NHMRC Investigator Fellow (2022-2026)
Member, ROME V International Committee for Disorders of Brain-Gut Interaction (2022- )
President, Australasian Neurogastroenterology and Motility Association (ANGMA, 2020-2022)
Co-Chair, 2021 Federation of Neurogastroenterology and Motility (FNM), Adelaide
NHMRC RD Wright Biomedical Fellow (CDF-II 2017-2020)
NHMRC RD Wright Biomedical Fellow (CDF-I 2013-2016)
NHMRC Australian Biomedical Fellow (2008-2012)
 
Key Awards:
Senior Researcher of 2021, Flinders University College of Medicine and Public Health
Mid-Career Researcher of 2018, Flinders University College of Medicine and Public Health
2017 NHMRC Research Excellence Award for being the top-ranked CDF-II Fellow
2011 South Australian Tall Poppy

Research Interests

MOLECULAR MECHANISMS OF ABDOMINAL PAIN: CAUSES AND CURES.

For most people pain normally serves as an alarm that is activated in response to tissue damage. However, for people who suffer from chronic or long term pain, it does not subside and can in fact worsen over time. Clinically, chronic pain is a major unresolved worldwide problem.

A/Prof Brierley's research focuses on pain arising from the gut with particular emphasis on Irritable Bowel Syndrome (IBS). In Australia IBS effects up to 15% of the population and although chronic pain is debilitating and significantly reduces a patient's quality of life there is no effective treatment. This research determines the mechanisms responsible for detecting painful events in the gut and how they change during acute and chronic conditions. It is clear that certain mechanisms are reprogrammed during chronic pain, which fail to "reset" back to normal. Overall, understanding how these mechanisms are changed is the first step in finding new therapeutic treatments for gut based pain.

Key aspects of gut based pain are discussed in Prof Brierley’s talk at the “Research Tuesday” free public seminar series at the University of Adelaide. Please see link below.

http://blogs.adelaide.edu.au/researchtuesdays/2012/01/19/get-your-stomach-in-mint-condition/

https://www.youtube.com/watch?v=D6_jjEPLKe4

https://www.youtube.com/watch?v=wqvjPAR4Xhc

 

Teaching Interests

RESEARCH OPPORTUNITIES ARE CURRENTLY AVAILABLE FOR MOTIVATED, OUTSTANDING APPLICANTS FOR HONOURS, MSC AND PHD POSITIONS:

1) TRP channels: Critical targets for the treatment of chronic visceral pain.

This project will investigate TRP channels in colonic sensory neurons, determine their mechano and chemosensory properties, and how their function changes across acute and chronic pain models. We will determine how TRP expression is altered in tissue from human patients with chronic visceral, thereby linking TRP levels with symptoms. Project funded by NHMRC Australia.

2) Other Projects:
 Several additional projects are available that we are happy to discuss with potential HDR students. These projects focus on other pain targets and are also funded by NHMRC Australia. Contact: stuart.brierley@adelaide.edu.au for details.

Techniques that students will perform include: electrophysiological afferent fibre recordings, patch clamp recordings, neuronal labeling, laser capture microdissection, QRT-PCR, tissue collection.

Date Position Institution name
2023 - ongoing Co-Theme leader of the Lifelong Health theme SAHMRI
2023 - ongoing Director of the Visceral Pain Research Group SAHMRI
2022 - ongoing NHMRC Investigator Leadership Fellow SAHMRI
2020 - ongoing Director of the Hopwood Centre for Neurobiology SAHMRI
2019 - 2023 Professor Flinders University
2017 - 2021 NHMRC R.D. Wright Biomedical Fellow (CDF II) Flinders University
2015 - ongoing Associate Professor University of Adelaide
2013 - 2016 NHMRC R.D. Wright Biomedical Fellow (CDF 1) University of Adelaide
2008 - 2012 NHMRC Australian Biomedical “Peter Doherty” Fellowship University of Adelaide

Date Type Title Institution Name Country Amount
2020 Distinction President Australasian Neurogastroenterology and Motility Association (ANGMA). Australia -

Date Institution name Country Title
University of Adelaide Australia PhD

Year Citation
2025 Touhara, K. K., Rossen, N. D., Deng, F., Castro, J., Harrington, A. M., Chu, T., . . . Julius, D. (2025). Topological segregation of stress sensors along the gut crypt-villus axis. Nature, 640(8059), 732-742.
DOI Scopus14 WoS12 Europe PMC12
2025 Decraecker, L., Cuende Estévez, M., Van Remoortel, S., Quan, R., Stakenborg, N., Wang, Z., . . . Boeckxstaens, G. (2025). Characterisation of MRGPRX2 + mast cells in irritable bowel syndrome. Gut, 74(7), 1068-1077.
DOI Scopus1 WoS1 Europe PMC1
2025 Rossen, N. D., Touhara, K. K., Castro, J., Harrington, A. M., Caraballo, S. G., Deng, F., . . . Julius, D. (2025). Population imaging of enterochromaffin cell activity reveals regulation by somatostatin. Proceedings of the National Academy of Sciences of the United States of America, 122(19), e2501525122-1-e2501525122-10.
DOI Scopus1 WoS1 Europe PMC3
2025 Brizuela, M., Bony, A. R., Garcia-Caraballo, S., Adams, D. J., & Brierley, S. M. (2025). GABAB receptor-mediated modulation of sensory neuron excitability: Roles of CaV2.2, G-protein-coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels in human and mouse nociception. Experimental Physiology, 18 pages.
DOI
2025 Venkataraman, A., Figueroa, E. E., Castro, J., Navarro, F. C., Soota, D., Brierley, S. M., . . . Ingraham, H. A. (2025). A cellular basis for heightened gut sensitivity in females.. Science (New York, N.Y.), 390(6779), 1285-1291.
DOI
2025 Wu, K., Jiang, H., Hicks, D. R., Liu, C., Muratspahić, E., Ramelot, T. A., . . . Baker, D. (2025). Design of intrinsically disordered region binding proteins. Science, 389(6757), 10 pages.
DOI Scopus12 WoS9 Europe PMC13
2025 Wang, Q., McGovern, A. E., Kyloh, M., Rychkov, G., Spencer, N. J., Mazzone, S. B., . . . Harrington, A. M. (2025). Splanchnic and Pelvic Spinal Afferent Pathways Relay Sensory Information From the Mouse Colorectum Into Distinct Brainstem Circuits. Journal of Neurochemistry, 169(9), e70211.
DOI Scopus1 WoS2 Europe PMC2
2024 Castro, J., Maddern, J., Erickson, A., Harrington, A. M., & Brierley, S. M. (2024). Peripheral and central neuroplasticity in a mouse model of endometriosis. Journal of Neurochemistry, 168(11), 3777-3800.
DOI Scopus12 WoS10 Europe PMC7
2024 Kremsmayr, T., Schober, G., Kaltenböck, M., Hoare, B. L., Brierley, S. M., & Muttenthaler, M. (2024). Oxytocin Analogues for the Oral Treatment of Abdominal Pain. Angewandte Chemie International Edition, 63(52), e202415333-1-e202415333-13.
DOI Scopus5 WoS5 Europe PMC2
2024 Touhara, K. K., Rossen, N. D., Deng, F., Chu, T., Harrington, A. M., Garcia Caraballo, S., . . . Julius, D. (2024). Crypt and Villus Enterochromaffin Cells are Distinct Stress Sensors in the Gut.. bioRxiv.
DOI
2024 Castro, J., Maddern, J., Chow, C. Y., Tran, P., Vetter, I., King, G. F., & Brierley, S. M. (2024). The voltage-gated sodium channel NaV1.7 underlies endometriosis-associated chronic pelvic pain. Journal of Neurochemistry, 168(11), 3760-3776.
DOI Scopus6 WoS6 Europe PMC5
2023 Grundy, L., Tay, C., Christie, S., Harrington, A. M., Castro, J., Cardoso, F. C., . . . Brierley, S. M. (2023). The T-type calcium channel Ca V 3.2 regulates bladder afferent responses to mechanical stimuli. Pain, 164(5), 1012-1026.
DOI Scopus5 WoS4 Europe PMC4
2023 Wang, Q. Q., Caraballo, S. G., Rychkov, G., McGovern, A. E., Mazzone, S. B., Brierley, S. M., & Harrington, A. M. (2023). Comparative localization of colorectal sensory afferent central projections in the mouse spinal cord dorsal horn and caudal medulla dorsal vagal complex. Journal of Comparative Neurology, 532(2), e25546-1-e25546-32.
DOI Scopus7 WoS6 Europe PMC5
2023 Brierley, S. M., & Spencer, N. J. (2023). Preface. Visceral Pain, v-vi.
2023 Bayrer, J. R., Castro, J., Venkataraman, A., Touhara, K. K., Rossen, N. D., Morrie, R. D., . . . Julius, D. (2023). Gut enterochromaffin cells drive visceral pain and anxiety. Nature, 616(7955), 137-142.
DOI Scopus103 WoS100 Europe PMC94
2022 Kyloh, M. A., Hibberd, T. J., Castro, J., Harrington, A. M., Travis, L., Dodds, K. N., . . . Spencer, N. J. (2022). Disengaging spinal afferent nerve communication with the brain in live mice. Communications Biology, 5(1), 915-1-915-15.
DOI Scopus13 WoS12 Europe PMC12
2022 Brierley, S. M., Greenwood-Van Meerveld, B., Sarnelli, G., Sharkey, K. A., Storr, M., & Tack, J. (2022). Targeting the endocannabinoid system for the treatment of abdominal pain in irritable bowel syndrome. Nature Reviews Gastroenterology and Hepatology, 20(1), 5-25.
DOI Scopus27 WoS25 Europe PMC21
2022 Castro, J., Garcia-Caraballo, S., Maddern, J., Schober, G., Lumsden, A., Harrington, A., . . . Brierley, S. M. (2022). Olorinab (APD371), a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2, reduces colitis-induced acute and chronic visceral hypersensitivity in rodents. Pain, 163(1), e72-e86.
DOI Scopus24 WoS24 Europe PMC20
2022 Maddern, J., Grundy, L., Harrington, A., Schober, G., Castro, J., & Brierley, S. M. (2022). A syngeneic inoculation mouse model of endometriosis that develops multiple comorbid visceral and cutaneous pain like behaviours. Pain, 163(8), 1622-1635.
DOI Scopus10 WoS9 Europe PMC7
2022 Castro, J., Harrington, A. M., Chegini, F., Matusica, D., Spencer, N. J., Brierley, S. M., . . . Barry, C. M. (2022). Clodronate Treatment Prevents Vaginal Hypersensitivity in a Mouse Model of Vestibulodynia.. Frontiers in Cellular and Infection Microbiology, 11, 784972-1-784972-11.
DOI Scopus9 WoS10 Europe PMC9
2022 Caldwell, A., Grundy, L., Harrington, A. M., Garcia-Caraballo, S., Castro, J., Bunnett, N. W., & Brierley, S. M. (2022). TGR5 agonists induce peripheral and central hypersensitivity to bladder distension. Scientific Reports, 12(1), 9920-1-9920-19.
DOI Scopus5 WoS3 Europe PMC2
2021 Brierley, S. M., Grundy, L., Castro, J., Harrington, A. M., Hannig, G., & Camilleri, M. (2021). Guanylate cyclase-C agonists as peripherally acting treatments of chronic visceral pain. Trends in Pharmacological Sciences, 43(2), 110-122.
DOI Scopus21 WoS20 Europe PMC18
2021 Rychkov, G. Y., Zhou, F. H., Adams, M. K., Brierley, S. M., Ma, L., & Barritt, G. J. (2021). Orai1- and Orai2-, but not Orai3-mediated ⁄CRAC is regulated by intracellular pH. The Journal of Physiology, 600(3), 1-12.
DOI Scopus7 WoS5 Europe PMC8
2021 Grundy, L., Caldwell, A., Garcia-Caraballo, S., Grundy, D., Spencer, N. J., Dong, X., . . . Brierley, S. M. (2021). Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension. The Journal of Neuroscience, 14(17), 3900-3916.
DOI Scopus14 WoS12 Europe PMC11
2021 Castro, J., Maddern, J., Grundy, L., Manavis, J., Harrington, A. M., Schober, G., & Brierley, S. M. (2021). A mouse model of endometriosis that displays vaginal, colon, cutaneous, and bladder sensory comorbidities. The FASEB Journal, 35(4), 1-20.
DOI Scopus17 WoS16 Europe PMC14
2021 Brizuela, M., Castro, J., Harrington, A. M., & Brierley, S. M. (2021). Pruritogenic mechanisms and gut sensation: putting the "irritant" into irritable bowel syndrome. American Journal of Physiology: Gastrointestinal and Liver Physiology, 320(6), G1131-G1141.
DOI Scopus9 WoS9 Europe PMC6
2021 Brierley, S. M. (2021). Food for thought about the immune drivers of gut pain. Nature, 590(7844), 41-43.
DOI Scopus2 WoS2 Europe PMC1
2021 Jiang, Y., Castro, J., Blomster, L. V., Agwa, A. J., Maddern, J., Schober, G., . . . King, G. F. (2021). Pharmacological Inhibition of the Voltage-Gated Sodium Channel Naν1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome. ACS Pharmacology and Translational Science, 4(4), 1362-1378.
DOI Scopus15 WoS16 Europe PMC16
2021 Muratspahić, E., Tomašević, N., Koehbach, J., Duerrauer, L., Hadžić, S., Castro, J., . . . Gruber, C. W. (2021). Design of a stable cyclic peptide analgesic derived from sunflower seeds that targets the κ-opioid receptor for the treatment of chronic abdominal pain. Journal of Medicinal Chemistry, 64(13), 9042-9055.
DOI Scopus25 WoS25 Europe PMC21
2021 Castro, J., Maddern, J., Erickson, A., Caldwell, A., Grundy, L., Harrington, A. M., & Brierley, S. M. (2021). Pharmacological modulation of voltage-gated sodium (Na(V)) channels alters nociception arising from the female reproductive tract. Pain, 162(1), 227-242.
DOI Scopus11 WoS12 Europe PMC9
2020 Braga Emidio, N., Brierley, S. M., Schroeder, C. I., & Muttenthaler, M. (2020). Structure, Function, and Therapeutic Potential of the Trefoil Factor Family in the Gastrointestinal Tract. ACS Pharmacology and Translational Science, 3(4), 583-597.
DOI Scopus32 WoS28 Europe PMC30
2020 Maddern, J., Grundy, L., Castro, J., & Brierley, S. M. (2020). Pain in endometriosis. Frontiers in Cellular Neuroscience, 14, 590823-1-590823-16.
DOI Scopus176 WoS154 Europe PMC126
2020 Uhlig, F., Grundy, L., Garcia-Caraballo, S., Brierley, S. M., Foster, S. J., & Grundy, D. (2020). Identification of a quorum sensing-dependent communication pathway mediating bacteria-gut-brain cross talk. iScience, 23(11), 101695-1-101695-16.
DOI Scopus22 WoS19 Europe PMC15
2020 Grundy, L., Caldwell, A., Lumsden, A., Mohammadi, E., Hannig, G., Greenwood Van-Meervald, B., & Brierley, S. M. (2020). Experimentally induced bladder permeability evokes bladder afferent hypersensitivity in the absence of inflammation. Frontiers in Neuroscience, 14(590871), 1-10.
DOI Scopus15 WoS13 Europe PMC13
2020 Dusan, M., Jastrow, C., Alyce, M. M., Yingkai, W., Shashikanth, M., Andelain, E., . . . Haberberger, R. (2020). Differentiation of the 50B11 dorsal root ganglion cells into NGF and GDNF responsive nociceptor subtypes. Molecular Pain, 16, 1-19.
DOI Scopus4 WoS4 Europe PMC5
2020 Harrington, A., Garcia-Caraballo, S., Grundy, L., Castro, J., Hannig, G., & Brierley, S. (2020). Mo1146 CHRONIC INTRA-COLONIC LINACLOTIDE ADMINISTRATION ALTERS GLIAL ACTIVATION IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY. Gastroenterology, 158(6), S-803.
DOI
2020 Morrie, R., Bayrer, J., Brierley, S., Ingraham, H., & Julius, D. (2020). SPARC - Mapping Gut-Spinal Cord Connections in Visceral Pain. FASEB JOURNAL, 34(S1), 1 page.
DOI
2020 Brierley, S. M., Goh, K. G. K., Sullivan, M. J., Moore, K. H., Ulett, G. C., & Grundy, L. (2020). Innate immune response to bacterial urinary tract infection sensitises high-threshold bladder afferents and recruits silent nociceptors. Pain, 161(1), 202-210.
DOI Scopus29 WoS25 Europe PMC25
2020 Cardoso, F. C., Castro, J., Grundy, L., Schober, G., Garcia-Caraballo, S., Zhao, T., . . . Lewis, R. J. (2020). A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. Pain, 162(2), 569-581.
DOI Scopus35 WoS34 Europe PMC27
2020 Grundy, L., Caldwell, A., Garcia Caraballo, S., Erickson, A., Schober, G., Castro Kraftchenko, J., . . . Brierley, S. M. (2020). Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H₁ receptor and TRPV1. American journal of physiology. Renal physiology, 318(2), F298-F314.
DOI Scopus58 WoS58 Europe PMC45
2020 Brierley, S. M. (2020). Gut nociceptors: sentinels promoting host defense. Cell Research, 30(4), 279-280.
DOI Scopus2 WoS2 Europe PMC2
2020 Tsukimi, Y., Pustovit, R. V., Harrington, A. M., Garcia-Caraballo, S., Brierley, S. M., Di Natale, M., . . . Furness, J. B. (2020). Effects and sites of action of a M1 receptor positive allosteric modulator on colonic motility in rats and dogs compared with 5-HT4 agonism and cholinesterase inhibition. Neurogastroenterology and Motility, 32(8), e13866-1-e13866-10.
DOI Scopus6 WoS6 Europe PMC5
2019 Konthapakdee, N., Grundy, L., O'Donnell, T., Garcia-Caraballo, S., Brierley, S. M., Grundy, D., & Daly, D. M. (2019). Serotonin exerts a direct modulatory role on bladder afferent firing in mice. The Journal of Physiology, 597(21), 5247-5264.
DOI Scopus22 WoS23 Europe PMC20
2019 Castro, J., Harrington, A. M., Lieu, T., Garcia Caraballo, S., Maddern, J., Schober, G., . . . Brierley, S. M. (2019). Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity. JCI insight, 4(20), e131712-1-e131712-24.
DOI Scopus62 WoS62 Europe PMC56
2019 Chess-Williams, R., Sellers, D. J., Brierley, S. M., Grundy, D., & Grundy, L. (2019). Purinergic receptor mediated calcium signalling in urothelial cells. Scientific Reports, 9(1), 16101-1-16101-10.
DOI Scopus13 WoS14 Europe PMC10
2019 Braga Emidio, N., Hoffmann, W., Brierley, S. M., & Muttenthaler, M. (2019). Trefoil factor family: unresolved questions and clinical perspectives. Trends in Biochemical Sciences, 44(5), 387-390.
DOI Scopus56 WoS54 Europe PMC45
2019 Israel, M. R., Tanaka, B. S., Castro Kraftchenko, J., Thongyoo, P., Robinson, S. D., Zhao, P., . . . Vetter, I. (2019). Nav1.6 regulates excitability of mechanosensitive sensory neurons. The Journal of Physiology, 597(14), 1-18.
DOI Scopus36 WoS37 Europe PMC31
2019 Harrington, A. M., Caraballo, S. G., Maddern, J. E., Grundy, L., Castro, J., & Brierley, S. M. (2019). Colonic afferent input and dorsal horn neuron activation differs between the thoracolumbar and lumbosacral spinal cord. American journal of physiology. Gastrointestinal and liver physiology, 317(3), G285-G303.
DOI Scopus34 WoS31 Europe PMC30
2019 Ge, P., Ren, J., Harrington, A. M., Grundy, L., Castro, J., Brierley, S. M., & Hannig, G. (2019). Linaclotide treatment reduces endometriosis-associated vaginal hyperalgesia and mechanical allodynia through viscerovisceral cross-talk.. Pain, 160(11), 2566-2579.
DOI Scopus32 WoS27 Europe PMC28
2019 Grundy, L., Erickson, A., & Brierley, S. M. (2019). Visceral Pain.. Annual review of physiology, 81(1), 261-284.
DOI Scopus203 WoS177 Europe PMC169
2019 Grundy, L., Harrington, A. M., Caldwell, A., Castro, J., Staikopoulos, V., Zagorodnyuk, V. P., . . . Brierley, S. M. (2019). Translating peripheral bladder afferent mechanosensitivity to neuronal activation within the lumbosacral spinal cord of mice. Pain, 160(4), 793-804.
DOI Scopus30 WoS29 Europe PMC26
2018 Brierley, S. M., Hibberd, T. J., & Spencer, N. J. (2018). Spinal afferent innervation of the colon and rectum. Frontiers in Cellular Neuroscience, 12, 467-1-467-14.
DOI Scopus88 WoS78 Europe PMC74
2018 Grundy, L., Caldwell, A., & Brierley, S. M. (2018). Mechanisms underlying overactive bladder and interstitial cystitis/painful bladder syndrome. Frontiers in Neuroscience, 12, 1-11.
DOI Scopus115 WoS109 Europe PMC90
2018 Grundy, L., Erickson, A., Caldwell, A., Garcia-Caraballo, S., Rychkov, G., Harrington, A., & Brierley, S. (2018). Tetrodotoxin-sensitive voltage-gated sodium channels regulate bladder afferent responses to distension. Pain, 159(12), 2573-2584.
DOI Scopus26 WoS29 Europe PMC23
2018 Grundy, L., Harrington, A. M., Castro, J., Garcia-Caraballo, S., Deiteren, A., Maddern, J., . . . Brierley, S. M. (2018). Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction. JCI Insight, 3(19), e121841-1-e121841-20.
DOI Scopus63 WoS60 Europe PMC58
2018 Grundy, L., & Brierley, S. (2018). Cross-organ sensitization between the colon and bladder: to pee or not to pee?. American Journal of Physiology - Gastrointestinal and Liver Physiology, 314(3), 301-308.
DOI Scopus56 WoS51 Europe PMC37
2018 Spencer, N., Greenheigh, S., Kyloh, M., Hibberd, T., Sharma, H., Grundy, L., . . . Zagorodnyuk, V. (2018). Identifying unique subtypes of spinal afferent nerve endings within the urinary bladder of mice. Journal of Comparative Neurology, 526(4), 707-720.
DOI Scopus40 WoS37 Europe PMC30
2018 Castro, J., Grundy, L., Deiteren, A., Harrington, A., O'Donnell, T., Maddern, J., . . . Brierley, S. (2018). Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain. British Journal of Pharmacology, 175(12), 2384-2398.
DOI Scopus40 WoS34 Europe PMC31
2018 Jami, S., Erickson, A., Brierley, S., & Vetter, I. (2018). Pain-causing venom peptides: insights into sensory neuron pharmacology. Toxins, 10(1), 1-15.
DOI Scopus34 WoS33 Europe PMC30
2018 Erickson, A., Deiteren, A., Harrington, A., Garcia-Caraballo, S., Castro, J., Caldwell, A., . . . Brierley, S. (2018). Voltage-gated sodium channels: (NaV)igating the field to determine their contribution to visceral nociception. The Journal of Physiology, 596(5), 785-807.
DOI Scopus35 WoS35 Europe PMC32
2018 Sadeghi, M., Erickson, A., Castro, J., Deiteren, A., Harrington, A., Grundy, L., . . . Brierley, S. (2018). Contribution of membrane receptor signalling to chronic visceral pain. International Journal of Biochemistry and Cell Biology, 98, 10-23.
DOI Scopus32 WoS27 Europe PMC25
2018 Guerrero-Alba, R., Valdez-Morales, E. E., Jiménez-Vargas, N. N., Bron, R., Poole, D., Reed, D., . . . Vanner, S. (2018). Co-expression of μ and ∂ opioid receptors by mouse colonic nociceptors. British Journal of Pharmacology, 175(13), 2622-2634.
DOI Scopus24 WoS21 Europe PMC21
2018 Desormeaux, C., Bautzova, T., Garcia Caraballo, S., Rolland, C., Barbaro, M. R., Brierley, S. M., . . . Cenac, N. (2018). Protease-activated receptor 1 is implicated in irritable bowel syndrome mediators-induced signaling to thoracic human sensory neurons. PAIN, 159(7), 1257-1267.
DOI Scopus37 WoS34 Europe PMC29
2018 Sadeghi, M., Carstens, B., Callaghan, B., Daniel, J., Tae, H., O'Donnell, T., . . . Clark, R. (2018). Structure-activity studies reveal the molecular basis for GABAB-receptor mediated inhibition of high voltage-activated calcium channels by α-conotoxin Vc1.1. ACS Chemical Biology, 13(6), 1577-1587.
DOI Scopus29 WoS31 Europe PMC24
2018 Salvatierra, J., Castro, J., Erickson, A., Li, Q., Braz, J., Gilchrist, J., . . . Bosmans, F. (2018). NaV1.1 inhibition can reduce visceral hypersensitivity. JCI insight, 3(11), e121000-1-e121000-13.
DOI Scopus32 WoS33 Europe PMC30
2018 Grundy, L., Chess-Williams, R., Brierley, S. M., Mills, K., Moore, K. H., Mansfield, K., . . . Grundy, D. (2018). NKA enhances bladder-afferent mechanosensitivity via urothelial and detrusor activation. American Journal of Physiology: Renal Physiology, 315(4), F1174-F1185.
DOI Scopus30 WoS29 Europe PMC25
2018 Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T. M., Latorre, R., Jensen, D. D., . . . Bunnett, N. W. (2018). Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome. Proceedings of the National Academy of Sciences of the United States of America, 115(31), E7438-E7447.
DOI Scopus144 WoS141 Europe PMC139
2017 Lee, M., McCubbin, J., Christensen, A., Poole, D., Rajasekhar, P., Lieu, T., . . . Cook, A. (2017). G-CSF receptor blockade ameliorates arthritic pain and disease. Journal of Immunology, 198(9), 3565-3575.
DOI Scopus33 WoS30 Europe PMC32
2017 Wan, J., Mobli, M., Brust, A., Muttenthaler, M., Andersson, Å., Ragnarsson, L., . . . Alewood, P. (2017). Synthesis of multivalent [Lys⁸]-oxytocin dendrimers that inhibit visceral nociceptive responses. Australian Journal of Chemistry, 70(2), 162-171.
DOI Scopus11 WoS10
2017 Inserra, M., Israel, M., Caldwell, A., Castro, J., Deuis, J., Harrington, A., . . . Vetter, I. (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports, 7(1), 42810-1-42810-19.
DOI Scopus63 WoS62 Europe PMC57
2017 Bellono, N., Bayrer, J., Leitch, D., Castro, J., Zhang, C., O'Donnell, T., . . . Julius, D. (2017). Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways. Cell, 170(1), 185-198.e16.
DOI Scopus712 WoS654 Europe PMC635
2017 Campaniello, M. A., Mavrangelos, C., Eade, S., Harrington, A. M., Blackshaw, L. A., Brierley, S. M., . . . Hughes, P. A. (2017). Acute colitis chronically alters immune infiltration mechanisms and sensory neuro-immune interactions.. Brain, Behavior, and Immunity, 60, 319-332.
DOI Scopus19 WoS16 Europe PMC14
2017 Fournel, A., Drougard, A., Duparc, T., Marlin, A., Brierley, S., Castro, J., . . . Knauf, C. (2017). Apelin targets gut contraction to control glucose metabolism via the brain.. Gut, 66(2), 258-269.
DOI Scopus84 WoS81 Europe PMC72
2017 Castro, J., Harrington, A., Garcia-Caraballo, S., Maddern, J., Grundy, L., Zhang, J., . . . Brierley, S. (2017). α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors. Gut, 66(6), 1083-1094.
DOI Scopus82 WoS77 Europe PMC72
2016 Brust, A., Croker, D., Colless, B., Ragnarsson, L., Andersson, Å., Jain, K., . . . Lewis, R. (2016). Conopeptide-derived κ-opioid agonists (conorphins): potent, selective, and metabolic stable dynorphin A mimetics with antinociceptive properties. Journal of Medicinal Chemistry, 59(6), 2381-2395.
DOI Scopus32 WoS32 Europe PMC28
2016 Carstens, B., Berecki, G., Daniel, J., Lee, H., Jackson, K., Tae, H., . . . Clark, R. (2016). Structure-activity studies of cysteine-Rich α-conotoxins that inhibit high-voltage-activated calcium channels via GABAB receptor activation reveal a minimal functional motif. Angewandte Chemie - International Edition, 55(15), 4692-4696.
DOI Scopus48 WoS46 Europe PMC36
2016 Osteen, J., Herzig, V., Gilchrist, J., Emrick, J., Zhang, C., Wang, X., . . . Julius, D. (2016). Selective spider toxins reveal a role for the Naᵥ1.1 channel in mechanical pain. Nature, 534(7608), 494-499.
DOI Scopus255 WoS242 Europe PMC218
2016 Grundy, L., Garcia-Caraballo, S., Maddern, J., Rychkov, G., Hannig, G., Kurtz, C., . . . Brierley, S. M. (2016). Chronic oral administration of the guanylate cyclase-C agonist linaclotide attenuates colitis induced bladder afferent hyperactivity. NEUROGASTROENTEROLOGY AND MOTILITY, 28, 29.
2016 Deiteren, A., Castro, J., O'Donnell, T., Craik, D. J., Adams, D. J., & Brierley, S. M. (2016). Modulation of colonic sensory signaling by novel α-conotoxin Vc1.1 analogues in mice. NEUROGASTROENTEROLOGY AND MOTILITY, 28, 103.
2016 Campaniello, M., Harrington, A., Martin, C., Ashley Blackshaw, L., Brierley, S., & Hughes, P. (2016). Activation of colo-rectal high-threshold afferent nerves by Interleukin-2 is tetrodotoxin-sensitive and upregulated in a mouse model of chronic visceral hypersensitivity. Neurogastroenterology and Motility, 28(1), 54-63.
DOI Scopus14 WoS13 Europe PMC12
2016 Grundy, L., Garcia-Caraballo, S., Maddern, J., Rychkov, G., Hannig, G., Kurtz, C., . . . Brierley, S. M. (2016). COLITIS INDUCES LONG-TERM BLADDER AFFERENT HYPERACTIVITY, WHICH IS ATTENUATED BY CHRONIC ORAL ADMINISTRATION OF THE GUANYLATE CYCLASE-C AGONIST LINACLOTIDE. JOURNAL OF UROLOGY, 195(4), E373.
DOI
2016 Grundy, L. A., Garcia-Carraballo, S., Maddern, J., Rychkov, G., Hannig, G., Kurtz, C. B., . . . Brierley, S. (2016). Chronic Oral Administration of the Guanylate Cyclase-C Agonist Linaclotide Attenuates Colitis Induced Bladder Afferent Hyperactivity. GASTROENTEROLOGY, 150(4), S118-S119.
DOI WoS3
2015 Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., . . . Brierley, S. M. (2015). Mo1876 A Visceral Representation of Itch: Identification ‘Itch-Specific’ Pruritogenic Mechanisms Within Colonic Sensory Pathways. Gastroenterology, 148(4), S-733.
DOI
2014 Hughes, P., Moretta, M., Lim, A., Grasby, D., Bird, D., Brierley, S., . . . Krumbiegel, D. (2014). Immune derived opioidergic inhibition of viscerosensory afferents is decreased in Irritable Bowel Syndrome patients. Brain, Behavior, and Immunity, 42, 191-203.
DOI Scopus48 WoS44 Europe PMC41
2014 de Araujo, A., Mobli, M., Castro, J., Harrington, A., Vetter, I., Dekan, Z., . . . Alewood, P. (2014). Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Coomunications, 5(1), 3165-1-3165-12.
DOI Scopus116 WoS115 Europe PMC82
2014 Malsch, P., Andratsch, M., Vogl, C., Link, A. S., Alzheimer, C., Brierley, S. M., . . . Kress, M. (2014). Deletion of interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression. Journal of Neuroscience, 34(30), 9845-9856.
DOI Scopus71 WoS65 Europe PMC65
2014 Brierley, S., & Linden, D. (2014). Neuroplasticity and dysfunction after gastrointestinal inflammation. Nature Reviews Gastroenterology and Hepatology, 11(10), 611-627.
DOI Scopus271 WoS254 Europe PMC225
2013 Blackshaw, L., Brierley, S., Harrington, A., & Hughes, P. (2013). TRP channels in visceral pain. The Open Pain Journal, 6(SPEC.ISSUE.1), 23-30.
DOI Scopus2
2013 Kentish, S., O'Donnell, T., Isaacs, N., Young, R., Li, H., Harrington, A., . . . Page, A. (2013). Gastric vagal afferent modulation by leptin is influenced by food intake status. Journal of Physiology-London, 591(7), 1921-1934.
DOI Scopus76 WoS71 Europe PMC61
2013 Hughes, P., Castro Kraftchenko, J., Harrington, A., Isaacs, N., Moretta, M., Hicks, G., . . . Brierley, S. (2013). Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity. Gut, Online(7), 1-2.
DOI Scopus38 WoS35 Europe PMC33
2013 Castro, J., Harrington, A., Hughes, P., Martin, C., Ge, P., Shea, C., . . . Brierley, S. (2013). Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-c and extracellular cyclic guanosine 3′,5′-monophosphate. Gastroenterology, 145(6), 1334-1346.
DOI Scopus252 WoS227 Europe PMC220
2013 Harrington, A., Brierley, S., Isaacs, N., Young, R., & Blackshaw, L. (2013). Identifying spinal sensory pathways activated by noxious esophageal acid. Neurogastroenterology and Motility, 25(10), 660-668.
DOI Scopus20 WoS16 Europe PMC15
2013 Hughes, P., Harrington, A., Castro Kraftchenko, J., Liebregts, T., Adam, B., Grasby, D., . . . Brierley, S. (2013). Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes. Gut, 62(10), 1456-1465.
DOI Scopus183 WoS166 Europe PMC149
2013 Blackshaw, L., & Brierley, S. (2013). Emerging receptor target in the pharmacotherapy of irritable bowel syndrome with constipation. Expert Review of Gastroenterology and Hepatology, 7(5), 15-19.
DOI Scopus17 WoS16 Europe PMC16
2012 Brierley, S. (2012). Guanylate cyclase-C receptor activation: unexpected biology. Current Opinion in Pharmacology, 12(6), 632-640.
DOI Scopus63 WoS57 Europe PMC50
2012 Harrington, A., Brierley, S., Isaacs, N., Hughes, P., Castro Kraftchenko, J., & Blackshaw, L. (2012). Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity. Journal of Comparative Neurology, 520(10), 2241-2255.
DOI Scopus62 WoS57 Europe PMC52
2012 Boakye, P., Stenkamp-Strahm, C., Bhattarai, Y., Heckman, M., Brierley, S., Pasilis, S., & Balemba, O. (2012). 5-HT₃ and 5-HT₄ receptors contribute to the anti-motility effects of Garcinia buchananii bark extract in the guinea-pig distal colon. Neurogastroenterology and Motility, 24(1), E27-E40.
DOI Scopus17 WoS12 Europe PMC12
2012 Boakye, P., Brierley, S., Pasilis, S., & Balemba, O. (2012). Garcinia buchananii bark extract is an effective anti-diarrheal remedy for lactose-induced diarrhea. Journal of Ethnopharmacology, 142(2), 539-547.
DOI Scopus27 WoS22 Europe PMC19
2012 Brierley, S., Castro, J., Harrington, A., Hughes, P., Martin, C., Silos-Santiago, A., . . . Blackshaw, A. (2012). Guanylate cyclase C receptor agonists, linaclotide and uroguanylin, modulate intestinal nociception. NEUROGASTROENTEROLOGY AND MOTILITY, 24, 26.
2011 Hughes, P. A., Brierley, S. M., & Martin, C. M. (2011). Post-inflammatory colonic afferent sensitisation: Different subtypes, different pathways and different time courses (Gut (2009) 58, (1333-1341)). Gut, 60(1), 140.
DOI Scopus1
2011 Harrington, A., Hughes, P., Martin, C., Yang, J., Castro, J., Isaacs, N., . . . Brierley, S. (2011). A novel role for TRPM8 in visceral afferent function. PAIN®, 152(7), 1459-1468.
DOI Scopus135 WoS122 Europe PMC117
2011 Liebregts, T., Adam, B., Bredack, C., Gururatsakul, M., Pilkington, K., Brierley, S., . . . Holtmann, G. (2011). Small bowel homing T cells are associated with symptoms and delayed gastric emptying in functional dyspepsia. American Journal of Gastroenterology, 106(6), 1089-1098.
DOI Scopus165 WoS153 Europe PMC139
2011 Brierley, S., & Kelber, O. (2011). Use of natural products in gastrointestinal therapies. Current Opinion in Pharmacology, 11(6), 604-611.
DOI Scopus47 WoS46 Europe PMC32
2011 Blackshaw, L., Brierley, S., Hughes, P., & Harrington, A. (2011). The Hot Mustard Receptor's Role in Gut Motor Function. Gastroenterology, 141(2), 423-427.
DOI Scopus9 WoS10 Europe PMC9
2011 Brierley, S., Castro Kraftchenko, J., Harrington, A., Hughes, P., Page, A., Rychkov, G., & Blackshaw, L. (2011). TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. Journal of Physiology-London, 589(14), 3575-3593.
DOI Scopus120 WoS109 Europe PMC110
2011 Harrington, A., Brierley, S. M., Castro, J., Hughes, P. A., & Blackshaw, L. A. (2011). Identification of Colonic Afferent Central Terminals and Changes Following Colonic Inflammation. Gastroenterology, 140(5), S-131.
DOI
2011 Castro, J., Harrington, A., Hughes, P. A., Martin, C., Page, A. J., Blackshaw, L. A., & Brierley, S. M. (2011). Nitric Oxide Mechanism of Action on Visceral Nociceptors. Gastroenterology, 140(5), S-536.
DOI
2011 Castro, J., Martin, C., Hughes, P. A., Silos-Santiago, A., Kurtz, C. B., Blackshaw, L. A., & Brierley, S. M. (2011). A Novel Role of Cyclic GMP in Colonic Sensory Neurotransmission in Healthy and TNBS-Treated Mice. Gastroenterology, 140(5), S-538.
DOI
2010 Brierley, S. (2010). Visualising vagal afferent neurons and their terminals whilst silencing TRPV1. Journal of Physiology-London, 588(21), 4069-4070.
DOI Scopus1 WoS1 Europe PMC1
2010 Brierley, S. (2010). Molecular basis of mechanosensitivity. Autonomic Neuroscience-Basic & Clinical, 153(1-2 Sp Iss), 58-68.
DOI Scopus44 WoS38 Europe PMC35
2010 Brierley, S. (2010). All ahead stop! How intestinal motility adapts to cope with inflammation induced ulceration. Journal of Physiology-London, 588(5), 753-754.
DOI
2010 Blackshaw, L., Brierley, S., & Hughes, P. (2010). TRP channels: new targets for visceral pain. Gut, 59(1), 126-135.
DOI Scopus71 WoS64 Europe PMC63
2010 Brierley, S., Hughes, P., Harrington, A., Rychkov, G., & Blackshaw, L. (2010). Identifying the ion channels responsible for signaling gastro-intestinal based pain. Pharmaceuticals, 3(9), 2768-2798.
DOI Scopus14 WoS11 Europe PMC10
2009 Blackshaw, L., & Brierley, S. (2009). Highlights in basic autonomic neurosciences. Autonomic Neuroscience-Basic & Clinical, 152(1), 1-3.
DOI
2009 Brierley, S., Hughes, P., Page, A., Kwan, K., Martin, C., O'Donnell, T., . . . Blackshaw, L. (2009). The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology, 137(6), 2084-2095.
DOI Scopus242 WoS218 Europe PMC199
2009 Hughes, P., Brierley, S., & Blackshaw, L. (2009). Post-inflammatory modification of colonic afferent mechanosensitivity. Clinical and Experimental Pharmacology and Physiology, 36(10), 1034-1040.
DOI Scopus61 WoS49 Europe PMC47
2009 Hughes, P., Brierley, S., Martin, C., Brookes, S., Linden, D., & Blackshaw, L. (2009). Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses. Gut, 58(10), 1333-1341.
DOI Scopus159 WoS144 Europe PMC147
2009 Hughes, P., Brierley, S., Martin, C., Liebregts, T., Persson, J., Adam, B., . . . Blackshaw, L. (2009). TRPV1-expressing sensory fibres and IBS: links with immune function. Gut, 58(3), 465-466.
DOI Scopus40 WoS34 Europe PMC25
2009 Young, R., Sutherland, K., Pezos, N., Brierley, S., Horowitz, M., Rayner, C., & Blackshaw, L. (2009). Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes. Gut, 2008(3), 337-346.
DOI Scopus159 WoS155 Europe PMC138
2009 Galán-Puchades, M. T., & Fuentes, M. V. (2009). The usefulness of ultrasound diagnosis specifically in taeniasis.. Gut, 58(3), 465.
DOI Europe PMC13
2008 Lindstrom, E., Brusberg, M., Hughes, P., Martin, C., Brierley, S., Phillis, B., . . . Blackshaw, L. (2008). Involvement of metabotropic glutamate 5 receptor in visceral pain. Pain, 137(2), 295-305.
DOI Scopus67 WoS55 Europe PMC51
2008 Brierley, S., Page, A., Hughes, P., Adam, B., Liebregts, T., Isaacs, N., . . . Blackshaw, L. (2008). Selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology, 134(7), 2059-2069.
DOI Scopus230 WoS198 Europe PMC194
2008 Sipe, W., Brierley, S., Martin, C., Phillis, B., Cruz, F., Grady, E., . . . Bunnett, N. (2008). Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia. American Journal of Physiology-Gastrointestinal and Liver Physiology, 294(5), G1288-G1298.
DOI Scopus128 WoS108 Europe PMC103
2007 Page, A., Brierley, S., Martin, C., Hughes, P., & Blackshaw, L. (2007). Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil. Pain, 133(1-3), 150-160.
DOI Scopus59 WoS44 Europe PMC43
2007 Page, A., Slattery, J., Brierley, S., Jacoby, A., & Blackshaw, L. (2007). Involvement of galanin receptors 1 and 2 in the modulation of mouse vagal afferent mechanosensitivity. Journal of Physiology-London, 583(2), 675-684.
DOI Scopus19 WoS12 Europe PMC14
2007 Page, A., Slattery, J., Milte, C., Laker, R., O'Donnell, T., Dorian, C., . . . Blackshaw, L. (2007). Ghrelin selectively reduces mechanosensitivity of upper gastrointestinal vagal afferents. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(5), G1376-G1384.
DOI Scopus104 WoS79 Europe PMC64
2007 Hughes, P., Brierley, S., Young, R., & Blackshaw, L. (2007). Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia. Journal of Comparative Neurology, 500(5), 863-875.
DOI Scopus88 WoS78 Europe PMC75
2007 Hughes, P., Brierley, S., Page, A., Kwan, K., Corey, D., & Blackshaw, L. A. (2007). The ion channel TRPA1 is expressed in extrinsic colonic afferents and contributes to their mechanosensitivity. NEUROGASTROENTEROLOGY AND MOTILITY, 19, 19.
2006 Slattery, J., Page, A., Dorian, C., Brierley, S., & Blackshaw, L. (2006). Potentiation of mouse vagal afferent mechanosensitivity by ionotropic and metabotropic glutamate receptors. Journal of Physiology-London, 577(1), 295-306.
DOI Scopus41 WoS36 Europe PMC34
2005 Brierley, S., Jones, C., Xu, L., Gebhart, G., & Blackshaw, L. (2005). Activation of splanchnic and pelvic colonic afferents by bradykinin in mice. Neurogastroenterology and Motility, 17(6), 854-862.
DOI Scopus75 WoS63 Europe PMC60
2005 Brierley, S., Carter, R., Jones III, W., Xu, L., Robinson, D., Hicks, G., . . . Blackshaw, L. (2005). Differential chemosensory function and receptor expression of splanchnic and pelvic colonic afferents in mice. Journal of Physiology-London, 567(1), 267-281.
DOI Scopus137 WoS120 Europe PMC116
2005 Page, A., Brierley, S., Martin, C., Price, M., Symonds, E., Butler, R., . . . Blackshaw, L. (2005). Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function. Gut, 54(10), 1408-1415.
DOI Scopus260 WoS229 Europe PMC221
2004 Page, A., Brierley, S., Martin, C., Martinez-Salgado, C., Wemmie, J., Brennan, T., . . . Blackshaw, L. (2004). The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function. Gastroenterology, 127(6), 1739-1747.
DOI Scopus139 WoS119 Europe PMC111
2004 Brierley, S., Jones, C., Gebhart, G., & Blackshaw, L. (2004). Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice. Gastroenterology, 127(1), 166-178.
DOI Scopus279 WoS252 Europe PMC244
2001 Brierley, S. M., Cooper, N. J., Lynn, P. A., & Blackshaw, L. A. (2001). Pelvic vs splanchnic colonic primary afferents. GASTROENTEROLOGY, 120(5), A178.
2001 Brierley, S., Nichols, K., Grasby, D., & Waterman, S. (2001). Neural mechanisms underlying migrating motor complex formation in mouse isolated colon. British Journal of Pharmacology, 132(2), 507-517.
DOI Scopus66 WoS64 Europe PMC58

Year Citation
2023 Brierley, S. M., & Spencer, N. J. (2023). Visceral Pain. S. M. Brierley, & N. J. Spencer (Eds.), Springer International Publishing.
DOI
2022 Spencer, N. J., Costa, M., & Brierley, S. M. (Eds.) (2022). The Enteric Nervous System II. Springer International Publishing.
DOI
2022 Spencer, N. J., Costa, M., & Brierley, S. M. (2022). Preface (Vol. 1383).
2016 Costa, M., & Brierley, S. (Eds.) (2016). The Enteric Nervous System. Springer International Publishing.
DOI
2016 Costa, M., & Brierley, S. (Eds.) (2016). The Enteric Nervous System. Springer International Publishing.
DOI
2016 Brierley, S., & Costa, M. (Eds.) (2016). Introduction to the ENS II 2014, 30 years later (Vol. 891). SPRINGER INT PUBLISHING AG.
2016 Brierley, S., & Costa, M. (Eds.) (2016). Introduction to the ENS II 2014, 30 years later (Vol. 891). SPRINGER INT PUBLISHING AG.

Year Citation
2023 Maddern, J., Brierley, S. M., & Castro, J. (2023). Pre-clinical Models of Endometriosis: A Focus on Chronic Pain. In Visceral Pain (pp. 209-222). Springer International Publishing.
DOI
2019 Brierley, S. M., Grundy, D., & Grundy, L. (2019). Gastrointestinal Sensation; General Principles. In Encyclopedia of Gastroenterology Second Edition (pp. 701-710). Elsevier.
DOI
2018 Harrington, A. M., Castro, J., Erickson, A., Grundy, L., & Brierley, S. M. (2018). Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract in Health and Disease. In H. M. Said (Ed.), Physiology of the Gastrointestinal Tract: Sixth Edition (Vol. 1-2, pp. 387-418). United Kingdom: Academic Press.
DOI Scopus22
2016 Brierley, S. (2016). Altered ion channel/receptor expression and function in extrinsic sensory neurons: The cause of and solution to chronic visceral pain?. In S. Brierley, & M. Costa (Eds.), The Enteric Nervous System 30 Years Later (Vol. 891, pp. 75-90). Switzerland AG: SPRINGER INTERNATIONAL PUBLISHING AG.
DOI Scopus10 WoS10 Europe PMC8
2016 Foong, J. P. P. (2016). Postnatal Development of the Mouse Enteric Nervous System. In S. Brierley, & M. Costa (Eds.), ENTERIC NERVOUS SYSTEM: 30 YEARS LATER (Vol. 891, pp. 135-143). SPRINGER INT PUBLISHING AG.
DOI WoS25
2012 Brierley, S. M., Hughes, P., Harrington, A., & Blackshaw, L. A. (2012). Innervation of the Gastrointestinal Tract by Spinal and Vagal Afferent Nerves. In Physiology of the Gastrointestinal Tract Two Volume Set (pp. 703-731).
DOI Scopus3
2012 Brierley, S., Hughes, P., Harrington, A., & Blackshaw, L. (2012). Innervation of the gastrointestinal tract by spinal and vagal afferent nerves. In L. Johnson, F. Ghishan, J. Kaunitz, J. Merchant, H. Said, & J. Wood (Eds.), Physiology of the Gastrointestinal Tract, Volume 1, Fifth Edition (Vol. 1, 5 ed., pp. 703-729). United Kingdom: Elsevier.
DOI Scopus17
2012 Hughes, P., Brierley, S., Castro Kraftchenko, J., Harrington, A., & Blackshaw, L. (2012). Experimental colitis models. In A. Szallasi, & T. Biro (Eds.), Methods in Pharmacology and Toxicology: TRP Channels in Drug Discovery, Volume II (Vol. 2, 1 ed., pp. 379-390). USA: Springer.
DOI Scopus1
2007 Brierley, S., & Blackshaw, L. (2007). The neurobiology of visceral nociceptors. In P. Pasricha, W. Willis, & G. Gebhart (Eds.), Chronic abdominal and visceral pain: theory and practice (pp. 45-66). New York: Informa.
Scopus8
2003 Brierley, S., Coldwell, J., Isaacs, N., Howarth, G., & Blackshaw, L. (2003). Colonic spinal primary afferents: mechanosensory and chemosensory subtypes and effects of inflammation. In G. Holtmann, & N. Talley (Eds.), Falk Symposium 130 - Gastrointestinal inflammation and disturbed gut function - the challenge of new concepts (Vol. 130, pp. 120-125). PO Box 17, 3300AA Dordrecht, The Netherlands: Kluwer Academic Publishers.

Year Citation
2021 Harrington, A., Wang, Q., Hannig, G., & Brierley, S. (2021). COLORECTAL NOCICEPTIVE PROCESSING IN THE ROSTRAL VENTROMEDIAL AND CAUDAL VENTROLATERAL MEDULLA IS INCREASED IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY AND IS REVERSED BY CHRONIC LINACLOTIDE TREATMENT. In GASTROENTEROLOGY Vol. 160 (pp. S630). ELECTR NETWORK: W B SAUNDERS CO-ELSEVIER INC.
2021 Castro, J., Maddern, J., Garcia-Caraballo, S., Schober, G., Lindstrom, B., Schmiel, S., & Brierley, S. (2021). CANNABINOID RECEPTOR 2 (CB<sub>2</sub>) LOCALIZATION IN COLONIC TISSUE AND PRIMARY SENSORY DORSAL ROOT GANGLIA (DRG) NEURONS ISOLATED FROM RODENTS WITH COLITIS AND CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 160 (pp. S503-S504). ELECTR NETWORK: W B SAUNDERS CO-ELSEVIER INC.
2020 Castro, J., Maddern, J., Garcia-Caraballo, S., Schober, G., Lindstrom, B., Schmiel, S., & Brierley, S. (2020). CANNABINOID RECEPTOR EXPRESSION AND THE EFFECT OF OLORINAB, A PERIPHERALLY ACTING, HIGHLY SELECTIVE, FULL AGONIST OF THE CANNABINOID RECEPTOR 2 (CB<sub>2</sub>), IN RODENTS WITH COLITIS AND CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 158 (pp. S269). Austin, TX: W B SAUNDERS CO-ELSEVIER INC.
2020 Castro, J., Maddern, J., Erickson, A., & Brierley, S. (2020). Co-morbidities of IBS: Role of voltage-gated sodium channels in mouse vaginal afferent mechanosensation and pain. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 32 (pp. 1 page). WILEY.
2020 Harrington, A., Garcia-Caraballo, S., Grundy, L., Castro, J., Hannig, G., & Brierley, S. (2020). CHRONIC INTRA-COLONIC LINACLOTIDE ADMINISTRATION ALTERS GLIAL ACTIVATION IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 158 (pp. S803). Austin, TX: W B SAUNDERS CO-ELSEVIER INC.
WoS1
2019 Castro, J., Maddern, J., Garcia-Caraballo, S., Lumsden, A. L., Lindstrom, B., Adams, J., & Brierley, S. (2019). OLORINAB (FORMERLY APD371), A PERIPHERALLY RESTRICTED, HIGHLY SELECTIVE, FULL AGONIST OF THE CANNABINOID RECEPTOR 2 (CB<sub>2</sub>), REDUCES VISCERAL HYPERSENSITIVITY IN ANIMAL MODELS. In GASTROENTEROLOGY Vol. 156 (pp. S382). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
WoS4
2019 Castro, J., Maddern, J., Garcia-Caraballo, S., Lumsden, A., Lindstrom, B., Adams, J., & Brierley, S. M. (2019). Olorinab (APD371), a peripherally restricted, highly selective, full agonist of the cannabinoid receptor type 2 (CB<sub>2</sub>), reduces visceral hypersensitivity in animal models. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 31 (pp. 2 pages). WILEY.
2019 Castro, J., Harrington, A., Maddern, J., Schober, G., Grundy, L. A., Ge, P., . . . Brierley, S. (2019). CHRONIC INTRACOLONIC ADMINISTRATION OF LINACLOTIDE INHIBITS NOCICEPTIVE SIGNALING IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 156 (pp. S570). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
WoS2
2019 Grundy, L., Castro, J., Maddern, J., Harrington, A., Hannig, G., Ge, P., & Brierley, S. (2019). CHRONIC COLONIC ADMINISTRATION OF THE GUANYLATE CYCLASE-C AGONIST LINACLOTIDE ATTENUATES COLITIS INDUCED BLADDER AFFERENT HYPERACTIVITY. In GASTROENTEROLOGY Vol. 156 (pp. S363). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
WoS1
2018 Brierley, S., Castro, J., Maddern, J., Garcia-Caraballo, S., Lindstrom, B., & Adams, J. (2018). APD371, a peripherally restricted, highly selective, full agonist of the Cannabinoid Receptor 2 (CB2), reduces colitis-induced visceral hypersensitivity in rats. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 2 pages). WILEY.
2018 Uhlig, F., Grundy, L., Castro, J., Brierley, S. M., Foster, S. J., & Grundy, D. (2018). Identification of modulators of intestinal nerve activity from <i>Staphylococcus aureus</i>. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY.
2018 Erickson, A., Garcia-Caraballo, S., Castro, J., Grundy, L., Rychkov, G., Vetter, I., . . . Brierley, S. (2018). Role of voltage-gated sodium channel isoforms in colon-innervating neurons in mice. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY.
2018 Grundy, L., Castro, J., Harrington, A., Garcia-Caraballo, S., Maddern, J., Rychkov, G., & Brierley, S. (2018). Colitis-induced chronic colonic hypersensitivity induces cross organ sensitisation of bladder afferent pathways. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY.
WoS1
2017 Grundy, L. A., Castro, J., Harrington, A., Peters, S., Feil, R., Miller, P., . . . Brierley, S. (2017). EXTRACELLULAR CGMP REDUCES THE EXCITABILITY OF SENSORY DORSAL ROOT GANGLION NEURONS VIA AN EXTRACELLULAR MECHANISM. In GASTROENTEROLOGY Vol. 152 (pp. S156). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
DOI WoS1
2015 Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., . . . Brierley, S. M. (2015). A Visceral Representation of Itch: Identification 'Itch-Specific' Pruritogenic Mechanisms Within Colonic Sensory Pathways. In GASTROENTEROLOGY Vol. 148 (pp. S733). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2015 Harrington, A. M., Castro, J., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., Grundy, L., . . . Brierley, S. M. (2015). GC-C Agonists As Regulators of Visceral Sensation: Modulation of Mucosal Sensitivity via the Epithelial GC-C/cGMP Pathway. In GASTROENTEROLOGY Vol. 148 (pp. S732-S733). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2015 Castro, J., Harrington, A. M., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., Grundy, L., . . . Brierley, S. M. (2015). Chronic Activation of the GC-C/cGMP Pathway by Linaclotide Inhibits Ascending Nociceptive Pathways and Restores Aberrant Spinal Cord Signaling. In GASTROENTEROLOGY Vol. 148 (pp. S194). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2014 Castro, J., Rychkov, G. Y., Ghetti, A., Harrington, A. M., Kurtz, C. B., Silos-Santiago, I., & Brierley, S. M. (2014). Extracellular Cyclic GMP (cGMP), the Downstream Mediator Released in Response to Linaclotide-Induced Activation of Guanylate Cyclase-C (GC-C), Reduces Excitability of Murine and Human Dorsal Root Ganglion (DRG) Neurons. In GASTROENTEROLOGY Vol. 146 (pp. S722). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
2014 Harrington, A. M., Castro, J., Garcia-Caraballo, S., Maddern, J., Craik, D., Adams, D. J., & Brierley, S. M. (2014). α-Conotoxin Vc1.1 Targets GABAB Receptors Modulating CaV2.2 and CaV2.3 Calcium Channels in Sensory Pathways Mediating Chronic Visceral Pain. In GASTROENTEROLOGY Vol. 146 (pp. S156). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
2013 Castro, J., Harrington, A. M., Mann, E. A., Cohen, M. B., Kurtz, C. B., Silos-Santiago, A., & Brierley, S. M. (2013). Mechanisms Underlying Linaclotide Induced Inhibition of Colonic Nociception. In GASTROENTEROLOGY Vol. 144 (pp. S134). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
2013 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C. B., Silos-Santiago, A., Nguyen, N. Q., . . . Brierley, S. M. (2013). Alterations in the Guanylate Cyclase-C/cGMP Pathway in Patients With Irritable Bowel Syndrome With Constipation. In GASTROENTEROLOGY Vol. 144 (pp. S59-S60). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
2013 Hughes, P. A., Harrington, A. M., Castro, J., Isaacs, N. J., Moretta, M., Hicks, G. A., . . . Brierley, S. M. (2013). Increased Efficacy of the Peripherally-Restricted Selective Kappa-Opioid Receptor Agonist, Asimadoline, in Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 144 (pp. S934-S935). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
2012 Hughes, P. A., Isaacs, N. J., Moretta, M., Hicks, G. A., Urso, D. M., Blackshaw, L. A., & Brierley, S. M. (2012). Identification of Kappa Opioid Receptors on Colonic Sensory Nerves and Their Up-Regulation in a Mouse Model of Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S702). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
2012 Castro, J., Harrington, A. M., Hughes, P. A., Martin, C., Silos-Santiago, A., Kurtz, C. B., . . . Brierley, S. M. (2012). Mechanism of Action for Linaclotide Induced Abdominal Pain Relief. In GASTROENTEROLOGY Vol. 142 (pp. S699). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
WoS5
2012 Harrington, A. M., Brierley, S. M., Castro, J., Isaacs, N. J., & Blackshaw, L. A. (2012). Characterization of Dorsal Horn Neurons Activated by Noxious Colorectal Distension in Health and Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S699). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
2012 Castro, J., Harrington, A. M., Page, A. J., & Brierley, S. M. (2012). Downstream Signaling Pathways of Nitric Oxide Induced Modulation of Colonic Afferent Mechanosensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S697). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
2011 Castro, J., Martin, C., Hughes, P. A., Silos-Santiago, A., Kurtz, C. B., Blackshaw, L. A., & Brierley, S. M. (2011). A Novel Role of Cyclic GMP in Colonic Sensory Neurotransmission in Healthy and TNBS-Treated Mice. In GASTROENTEROLOGY Vol. 140 (pp. S538). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
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2011 Castro, J., Harrington, A., Hughes, P. A., Martin, C., Page, A. J., Blackshaw, L. A., & Brierley, S. M. (2011). Nitric Oxide Mechanism of Action on Visceral Nociceptors. In GASTROENTEROLOGY Vol. 140 (pp. S536). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
2011 Adam, B., Liebregts, T., Bredack, C., Brierley, S. M., Hughes, P. A., Blackshaw, L. A., . . . Holtmann, G. (2011). Small Bowel Homing T Cells Are Associated With Symptoms and Delayed Gastric Emptying in Functional Dyspepsia. In GASTROENTEROLOGY Vol. 140 (pp. S139). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
2011 Harrington, A., Brierley, S. M., Castro, J., Hughes, P. A., & Blackshaw, L. A. (2011). Identification of Colonic Afferent Central Terminals and Changes Following Colonic Inflammation. In GASTROENTEROLOGY Vol. 140 (pp. S131). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
2011 Castro, J., Balemba, O. B., Blackshaw, L. A., & Brierley, S. M. (2011). Garcinia Buchananii Bark Extract Inhibits Nociceptors, With Greater Efficacy During Inflammation. In GASTROENTEROLOGY Vol. 140 (pp. S866). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
WoS7
2011 Balemba, O. B., Boakye, P. A., Brierley, S. M., & Pasilis, S. P. (2011). Garcinia Buchananii Bark Extract is an Effective Anti-Diarrheal Remedy. In GASTROENTEROLOGY Vol. 140 (pp. S284). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
WoS1
2010 Hughes, P., Brierley, S., Harrington, A., Castro, J., Martin, C., & Blackshaw, L. (2010). Differential coupling of cytokine receptors to sensory neurons in health and post inflammation. In Proceedings Vol. 138 (pp. 136-137). W B SAUNDERS CO-ELSEVIER INC.
DOI
2010 Harrington, A., Young, R., Brierley, S., & Blackshaw, L. (2010). TRPV1 mediates acid activation of esophageal sensory pathways. In Proceedings of 2010 Joint International Neurogastroenterology and Motility Meeting, NGM 2010 Vol. 22 (pp. 55). UK: Wiley-Blackwell Publishing Ltd.
2009 Harrington, A., Hughes, P., Martin, C., Isaacs, N., Brierley, S., & Blackshaw, L. (2009). Localisation and function of transient receptor potential ion channel melastatin subtype 8 (TRPM8) in mouse colonic primary afferent nerve fibers. In Autonomic neuroscience Vol. 149 (pp. 29). United States: Elsevier B.V..
DOI
2009 Brierley, S., Harrington, A., Hughes, P., Page, A., Corey, D., Kwan, K., . . . Blackshaw, L. (2009). TRPA1 contributes to specific mechanotransduction currents in isolated DRG neurons. In TRP Channels: From Sensory Signaling to Human Disease (pp. 76). Stockholm, Sweden.
2009 Hughes, P. A., Brierley, S. M., Persson, J., Liebregts, T., Adam, B., Holtmann, G., & Blackshaw, L. A. (2009). Immune Cell Supernatants from IBS Patient Subtypes Differentially Affect Visceral Afferent Mechanosensitivity. In GASTROENTEROLOGY Vol. 136 (pp. A75). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
2008 Hughes, P. A., Brierley, S. M., Liebregts, T., Adam, B., Holtmann, G. J., & Blackshaw, L. A. (2008). Sensitization of visceral afferents by immune cell supernatants from IBS patients. In GASTROENTEROLOGY Vol. 134 (pp. A553). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
2008 Hughes, P. A., Brierley, S. M., & Blackshaw, L. A. (2008). Delayed post-inflammatory hypersensitivity in sub-populations of colonic afferents. In GASTROENTEROLOGY Vol. 134 (pp. A553). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
2008 Brierley, S. M., Hughes, P. A., Page, A. J., O'Donnell, T. A., Martin, C. M., Kwan, K. Y., . . . Blackshaw, L. A. (2008). Novel and specific roles for the ion channel TRPA1 in visceral sensory transduction. In GASTROENTEROLOGY Vol. 134 (pp. A8). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
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2008 Liebregts, T., Junne, J. G., Adam, B., Brierley, S. M., Blackshaw, L. A., Gerken, G., & Holtmann, G. J. (2008). Impaired steroid sensitivity of peripheral blood mononuclear cells in patients with irritable bowel syndrome. In GASTROENTEROLOGY Vol. 134 (pp. A689). W B SAUNDERS CO-ELSEVIER INC.
2008 Adam, B., Liebregts, T., Brierley, S. M., Blackshaw, L. A., & Holtmann, G. J. (2008). Small bowel homing T lymphocytes and symptom severity in patients with functional dyspepsia. In GASTROENTEROLOGY Vol. 134 (pp. A690). W B SAUNDERS CO-ELSEVIER INC.
2008 Page, A. J., O'Donnell, T. A., Koch, L., Brierley, S. M., & Blackshaw, L. A. (2008). Switching of leptin effects on peripheral vagal afferent mechanosensitivity with feeding and fasting. In GASTROENTEROLOGY Vol. 134 (pp. A97). W B SAUNDERS CO-ELSEVIER INC.
2008 Sutherland, K., Brierley, S. M., Rayner, C., Horowitz, M., Blackshaw, L. A., & Young, R. L. (2008). Altered duodenal sweet taste receptor expression in diabetic hyperglycemia. In GASTROENTEROLOGY Vol. 134 (pp. A44). W B SAUNDERS CO-ELSEVIER INC.
2007 Sutherland, K., Brierley, S. M., Horowitz, M., Rayner, C., Blackshaw, L. A., & Young, R. L. (2007). Sweet taste transduction molecules are expressed in the upper gastrointestinal tract in humans. In GASTROENTEROLOGY Vol. 132 (pp. A587). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
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2007 Sipe, W. E., Vergnolle, N., Phillis, B. D., Brierley, S. M., Martin, C. M., Blackshaw, L. A., & Bunnett, N. W. (2007). Transient receptor potential vanilloid 4 (TRPV4) mediates inflammation-induced sensitization of colonic afferent nerves and mechanical hyperalgesia. In GASTROENTEROLOGY Vol. 132 (pp. A599). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2007 Adam, B., Liebregts, T., Bredack, C., Brierley, S. M., Pilkington, K. R., Junne, J. G., . . . Holtmann, G. (2007). Gut homing properties of circulating T cells in patients with irritable bowel syndrome (IBS). In GASTROENTEROLOGY Vol. 132 (pp. A388). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2007 Liebregts, T., Adam, B., Bredack, C., Lester, S., Dowme-doyle, S., Brierley, S. M., . . . Holtmann, G. (2007). CTLA-4 haplotypes and Cd4+Cd25+Foxp3+ regulatory T cells in irritable bowel syndrome. In GASTROENTEROLOGY Vol. 132 (pp. A137). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2007 Brierley, S. M., Hughes, P. A., Page, A. J., & Blackshaw, L. A. (2007). Mechanical hypersensitivity of mouse colonic afferents after activation of the ion channel Trpa1. In GASTROENTEROLOGY Vol. 132 (pp. A600). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2007 Brierley, S. M., Hughes, P. A., Page, A. J., Adam, B., Liebregts, T., Holtmann, G., . . . Blackshaw, L. (2007). Mice lacking the TRPV4 ion channel display major deficits in spinal colonic but not vagal gastroesophageal mechanosensory function. In GASTROENTEROLOGY Vol. 132 (pp. A156). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
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2007 Pezos, N., Sutherland, K., Brierley, S. M., Horowitz, M., Blackshaw, L. A., & Young, R. L. (2007). Vagal afferents do not directly detect intestinal glucose via a sweet-taste mechanism. In GASTROENTEROLOGY Vol. 132 (pp. A587). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2007 Jensen, J., Branden, L., Brierley, S. M., Cooper, N. J., Green, M., Ahlefelt, M., . . . Blackshaw, L. A. (2007). Modulation of visceral afferents by large conductance KCA channels. In GASTROENTEROLOGY Vol. 132 (pp. A126). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2006 Page, A. J., Slattery, J., O'Donnell, T. A., Brierley, S., Milte, C., Laker, R., & Blackshaw, L. A. (2006). Ghrelin reduces mechanical sensitivity of gastroesophageal vagal afferents in ferrets and mice. In GASTROENTEROLOGY Vol. 130 (pp. A228). Los Angeles, CA: W B SAUNDERS CO-ELSEVIER INC.
2005 Brierley, S. M., Price, M. P., Wemmie, J. A., Welsh, M. J., & Blackshaw, L. A. (2005). ASIC1, 2 & 3 contribute differently to colonic serosal & mesenteric mechanoreceptor function. In GASTROENTEROLOGY Vol. 128 (pp. A124-A125). Chicago, IL: W B SAUNDERS CO.
2003 Brierley, S. M., Wemmie, J. A., Welsh, M. J., & Blackshaw, L. A. (2003). ASIC ion channels contribute to colonic mechanosensory function in mice. In GASTROENTEROLOGY Vol. 124 (pp. A39). ORLANDO, FLORIDA: W B SAUNDERS CO.
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2002 Brierley, S., Cooper, N., & Blackshaw, L. A. (2002). Pelvic colonic primary afferents: Mechanosensory and pharmacological subtypes. In GASTROENTEROLOGY Vol. 122 (pp. A527). W B SAUNDERS CO.
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2002 Coldwell, J. R., Brierley, S. M., Cooper, N. J., & Blackshaw, L. A. (2002). Structural and functional aspects of mechanoreceptor endings in rat colon. In JOURNAL OF PHYSIOLOGY-LONDON Vol. 543 (pp. 4P-5P). UNIV LIVERPOOL, LIVERPOOL, ENGLAND: CAMBRIDGE UNIV PRESS.

Year Citation
2022 Harrington, A., Schober, G., Maddern, J., Wang, Q., Hannig, G., & Brierley, S. (2022). Descending pain modulation of colorectal nociceptive processing in the spinal cord is imbalanced in a mouse model of post-colitis chronic visceral hypersensitivity and is reduced by chronic oral linaclotide treatment. Poster session presented at the meeting of Abstracts of Digestive Disease Week (DDW 2022), as published in Gastroenterology. San Diego, CA: Elsevier.
DOI
2022 Harrington, A., Wang, Q., Hannig, G., & Brierley, S. (2022). Colorectal nociceptive processing in the caudal ventrolateral medulla and the lateral parabrachial nuclei is increased in a mouse model of chronic visceral hypersensitivity and is reversed by chronic linaclotide treatment. Poster session presented at the meeting of Abstracts of Digestive Disease Week (DDW 2022), as published in Gastroenterology. San Diego, CA: Elsevier.
DOI
2020 Castro, J., Maddern, J., Garcia-Caraballo, S., Schober, G., Lindstrom, B., Schmiel, S., & Brierley, S. M. (2020). Olorinab, a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2 (CB2), reduces visceral hypersensitivity in mice. Poster session presented at the meeting of Abstracts of the 4th Meeting of the Federation of Neurogastroenterology and Motility (FNM 2020), as published in Neurogastroenterology & Motility. Adelaide Convention Centre, Adelaide, Australia: Wiley.
DOI
2019 Lindstrom, B. F., Ruckle, J. L., Turner, S. A., Stauber, K., Brierley, S. M., English, B. A., & Yacyshyn, B. (2019). P139 OLORINAB, A PERIPHERALLY RESTRICTED, HIGHLY SELECTIVE AGONIST OF THE CANNABINOID RECEPTOR TYPE 2 FOR THE MANAGEMENT OF VISCERAL PAIN IN INFLAMMATORY BOWEL DISEASE (IBD) – PRECLINICAL AND EARLY CLINICAL DEVELOPMENT. Poster session presented at the meeting of Gastroenterology. Las Vegas, NV: Elsevier BV.
DOI WoS3
2019 Lindstrom, B. F., Ruckle, J. L., Turner, S. A., Stauber, K., Brierley, S. M., English, B. A., & Yacyshyn, B. (2019). P139 OLORINAB, A PERIPHERALLY RESTRICTED, HIGHLY SELECTIVE AGONIST OF THE CANNABINOID RECEPTOR TYPE 2 FOR THE MANAGEMENT OF VISCERAL PAIN IN INFLAMMATORY BOWEL DISEASE (IBD) – PRECLINICAL AND EARLY CLINICAL DEVELOPMENT. Poster session presented at the meeting of Inflammatory Bowel Diseases. Las Vegas, NV: Oxford University Press (OUP).
DOI WoS2
2019 Grundy, L., Ulett, G., & Brierley, S. (2019). Supernatant from acute uropathogenic e-coli infection exclusively sensitises high threshold bladder afferents and recruits 'silent nociceptors'. Poster session presented at the meeting of Abstracts of the 114th Annual Meeting of the American Urological Association (AUA), as published in Journal of Urology. Chicago, IL: Wolters Kluwer Health.
DOI
2019 Grundy, L., Harrington, A., Caldwell, A., Castro, J., Zagorodnyuk, V., Brookes, S., . . . Brierley, S. (2019). Low and high threshold mechanosensitive bladder afferent pathways converge to a similar distribution of lumbosacral spinal neurons. Poster session presented at the meeting of Abstracts of the 114th Annual Meeting of the American Urological Association (AUA), as published in Journal of Urology. Chicago, IL: Wolters Kluwer Health.
DOI
2017 Grundy, L., Garcia-Caraballo, S., Maddern, J., Rychkov, G., Ge, P., Hannig, G., . . . Brierley, S. (2017). Chronic oral administration of the guanylate cyclase-c agonist linaclotide attenuates colitis induced bladder afferent and dorsal root ganglion hyperactivity. Poster session presented at the meeting of Abstracts of the 112th Annual Meeting of the American Urological Association (AUA2017), as published in Journal of Urology. MA, Boston: Wolters Kluwer Health.
DOI
2017 Grundy, L., Caldwell, A., Garcia-Caraballo, S., Rychkov, G., & Brierley, S. (2017). Identification of novel irritant sensing mechanisms in the bladder. Poster session presented at the meeting of Abstracts of the 112th Annual Meeting of the American Urological Association (AUA2017), as published in Journal of Urology. Boston, MA: Wolters Kluwer Health.
DOI
2017 Castro, J., Deiteren, A., Harrington, A., Maddern, J., Moore, J., Garcia-Caraballo, S., . . . Brierley, S. (2017). Chronic oral administration of linaclotide inhibits nociceptive signalling in response to noxious colorectal distension in a model of chronic visceral hypersensitivity. Poster session presented at the meeting of Abstracts of the Digestive Disease Week (DDW) 2017, as published in Gastroenterology. Chicago, IL: Elsevier.
DOI WoS1
2017 Deiteren, A., Doms, S., Castro, J., Garcia-Caraballo, S., Ostertag, D., & Brierley, S. (2017). The histamine receptor H4 is functionally expressed on murine colonic sensory neurons and contributes to chronic visceral hypersensitivity. Poster session presented at the meeting of Abstracts of the NeuroGASTRO 2017 Congress, as published in Neurogastroenterology and Motility. Cork, Ireland: Wiley.
DOI
2016 Garcia-Caraballo, S., Harrington, A. M., Castro, J., Hannig, G., Kurtz, C., Silos-Santiago, A., . . . Brierley, S. M. (2016). Guanylate cyclase-C expression is down-regulated in colonic biopsies from female irritable bowel syndrome patients with constipation. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
2016 Carstens, B., Berecki, G., Daniel, J., Lee, H. S., Jackson, K., Tae, H. -S., . . . Clark, R. (2016). MINIATURISED ALPHA-CONOTOXINS FOR THE TREATMENT OF PAIN. Poster session presented at the meeting of JOURNAL OF PEPTIDE SCIENCE. WILEY.
2016 Garcia-Carraballo, S., Harrington, A., Castro, J., Hannig, G., Kurtz, C. B., Silos-Santiago, A., . . . Brierley, S. (2016). Guanylate Cyclase-C Expression Is Down-Regulated in Colonic Biopsies From Female Irritable Bowel Syndrome Patients With Constipation. Poster session presented at the meeting of GASTROENTEROLOGY. San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
DOI WoS2
2014 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C. B., Silos-Santiago, I., Nguyen, N. Q., . . . Brierley, S. M. (2014). Distinct Alterations in the Guanylate Cyclase-C (GC-C)/Cyclic GMP (cGMP) Pathway Are Evident Across Different Subtypes of Irritable Bowel Syndrome (IBS) Patients. Poster session presented at the meeting of GASTROENTEROLOGY. Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
WoS3
2014 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C., Silos-Santiago, A., Nguyen, N., . . . Brierley, S. M. (2014). Distinct alterations in the guanylate cyclase-C/cGMP pathway are evident across different subtypes of irritable bowel syndrome patients. Poster session presented at the meeting of Neurogastroenterology and Motility. Guangzhou, China: John Wiley and Sons.
DOI
2014 Kentish, S. J., O'Donnell, T. A., Brierley, S. M., Kurtz, C., Silos-Santiago, A., & Page, A. J. (2014). Differential effects of extracellular cyclic GMP (cGMP) and the guanylate cyclase-C (GC-C) agonist, linaclotide, on mouse gastric vagal afferent mechanosensitivity. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
2014 Castro, J., Rychkov, G. Y., Ghetti, A., Harrington, A. M., Kurtz, C., Silos-Santiago, A., & Brierley, S. M. (2014). Extracellular cGMP, the downstream effector released in response to linaclotide-induced activation of guanylate cyclase-C, reduces excitability of murine and human dorsal root ganglion neurons. Poster session presented at the meeting of Neurogastroenterology and Motility. Guangzhou, China: John Wiley and Sons.
DOI WoS1
2013 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C., Silos-Santiago, A., Nguyen, N., . . . Brierley, S. M. (2013). The guanylatecyclase-c/CGMP pathway is altered in patients with irritable bowel syndrome with constipation. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
DOI
2013 Hughes, P. A., Moretta, M., Bird, D., Grasby, D., Lim, A., Brierley, S. M., . . . Krumbiegel, D. (2013). Beta-endorphin secretion by monocyte/macrophages is deficient in irritable bowel syndrome: a contributor to visceral hypersensitivity?. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
2013 Hannig, G., Castro, J., Harrington, A., Ge, P., Jin, H., Kessler, M. M., . . . Silos-Santiago, I. (2013). Activation of the guanylate cyclase-C/cGMP pathway decreases gastrointestinal pain. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Shanghai, China: Wiley.
DOI
2013 Harrington, A. M., Castro, J., & Brierley, S. M. (2013). Peripheral modulation of TRPA1 alters dorsal horn neuron activation to colorectal distension. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY.
2013 Castro, J., Harrington, A. M., & Brierley, S. M. (2013). TRPV3 contributes to chronic visceral mechanical hypersensitivity. Poster session presented at the meeting of Abstracts of the 17th American Neurogastroenterology and Motility Society Annual Scientific Meeting, as published in Neurogastroenterology & Motility. Huntington Beach, California: Wiley-Blackwell.
DOI
2013 Castro, J., Harrington, A. M., Mann, E., Cohen, M. B., Kurtz, C., Silos-Santiago, A., & Brierley, S. M. (2013). Mechanisms of linaclotide-induced inhibition of colonic nociception. Poster session presented at the meeting of Abstracts of the 17th American Neurogastroenterology and Motility Society Annual Scientific Meeting, as published in Neurogastroenterology & Motility. Huntington Beach, CA: Wiley-Blackwell.
DOI
2013 Brierley, S. M., Castro, J., Harrington, A., Hughes, P., Martin, C., Silos-Santiago, A., . . . Blackshaw, A. (2013). MECHANISM OF ACTION FOR LINACLOTIDE-INDUCED ABDOMINAL PAIN RELIEF. Poster session presented at the meeting of GUT. Glasgow, SCOTLAND: BMJ PUBLISHING GROUP.
DOI
2012 Hughes, P., Nicholson, I., Bird, D., To, S., Isaacs, N., Grasby, D., . . . Krumbiegel, D. (2012). C-IBS patients lack monocyte derived β-endorphin which results in disinhibition of colonic afferent mechanosensitivity. Poster session presented at the meeting of Gastroenterology. USA: WB Saunders.
DOI
2012 Hughes, P. A., Bird, D., Brierley, S. M., Persson, J., Moretta, M., Blackshaw, L. A., . . . Andrews, J. M. (2012). TNF-alpha from gut homing memory T cells and monocytes sensitises colonic sensory afferents in IBS-D. Poster session presented at the meeting of Neurogastroenterology and Motility: Supplement. Bologna, Italy: WILEY-BLACKWELL.
2011 Hughes, P., Harrington, A., Brierley, S., Maldeniya, M., Martin, C., Persson, J., . . . Blackshaw, L. (2011). Cytokine modulation of visceral afferents via cation channels is switched in chronic visceral hypersensitivity. Poster session presented at the meeting of Gastroenterology. Chicago, IL: W B Saunders Co.
DOI
2011 Castro, J., Hughes, P. A., Martin, C. M., Silos-Santiago, A., Kurtz, C., Black-Shaw, L. A., & Brierley, S. M. (2011). Extracellular cGMP has contrasting effects on colonic afferent mechanosensitivity in control and tnbs-treated mice. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
2010 Young, R., Sutherland, K., Pezos, N., Brierley, S., Ma, J., Rayner, C., . . . Blackshaw, L. (2010). Control of intestinal sweet taste receptor expression is impaired in type 2 diabetes. Poster session presented at the meeting of Proceedings of 2010 Joint International Neurogastroenterology and Motility Meeting (NGM), as published in Neurogastroenterology & Motility. Boston, MA, USA: Wiley-Blackwell Publishing.
DOI WoS2
2010 Brierley, S., Castro Kraftchenko, J., Martin, C., Harrington, A., Hughes, P., & Blackshaw, L. (2010). Differential regulation of TRP channel function in acute and chronic mechanical hypersensitivity. Poster session presented at the meeting of Abstract of theJoint International Neurogastroenterology and Motility Meeting, as published in Neurogastroenterology and Motility. Boston, MA, USA: Wiley-Blackwell Publishing.
DOI

Year Citation
2025 Venkataraman, A., Figueroa, E. E., Castro, J., Navarro, F. M. C., Soota, D., Brierley, S. M., . . . Ingraham, H. A. (2025). A Cellular Basis for Heightened Gut Sensitivity in Females..
DOI
2020 Grundy, L., Caldwell, A., Garcia-Caraballo, S., Grundy, D., Spencer, N., Dong, X., . . . Brierley, S. (2020). Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension.
DOI

Research Funding

NHMRC AUSTRALIA:

i) Current:

2022-2026: Prof Stuart M. Brierley. NHMRC Investigator (L1) Grant. “Identifying the underlying causes and discovering novel therapeutic treatments for chronic visceral pain (CVP)”. APP2008727. AUD $2,173,555.00

2022-2024: NHMRC Development Grant (APP2014250). (AUD $998,858.88). Chief Investigators: Prof Stuart M Brierley, Prof Glenn King. “Developing a first-in-class therapeutic for chronic visceral pain using venom derived peptides”

 

ii) Previous:

2020-2023: U01 NS113869 (SPARC/HEAL) (USD$ 2,536,899). CIs: Prof David Julius, Prof Holly Ingraham, Dr James Bayrer, Prof Stuart Brierley “Mapping gut-spinal cord connections in visceral pain”

2020-2023: U01 NS113871 (SPARC/HEAL) (USD$ 2,159,613) CIs: Prof Million Mulugeta, Prof Stuart Brierley, Prof Evgeniy Kreydin, Dr Muriel Larauche, Dr Lixin Wang, Prof Reggie Edgerton, “Structural and functional mapping of visceral pain afferent neurocircuitries of the colorectum and bladder in preclinical models”

2019-2022: NHMRC Project grant. APP1156427 (AUD $988,243). Chief Investigators: N.J. Spencer, Prof Stuart M Brierley, V. Zagorodnyuk & A Harrington. “Silencing visceral pain pathways using novel optogenetic techniques in vivo” 

2018-2020: ARC Discovery Project: DP180101395. (AUS$331,000). Chief Investigators: Dr Andrea Harrington, A/Prof Stuart M. Brierley, A/Prof Stuart Mazzone, A/Prof Grigori Rychkov. “Central pathways regulating visceral pain”

2017-2020: A/Prof Stuart M. Brierley, NHMRC R.D Wright Fellowship (Level 2). APP1126378 (AUD $470,144).

“Identifying the underlying causes of chronic visceral pain and discovering novel therapeutic treatments”.  Top ranked CDF II in the 2016 round.

2018-2020: NHMRC Project Grant APP1139366.  (AUD $696,808.50). Chief Investigators: A/Prof Stuart M Brierley, Prof Richard Lewis, A/Prof Irina Vetter, A/Prof Grigori Rychkov. “Silencing visceral nociceptors by targeting NaV1.1: A novel therapeutic approach for treating Irritable Bowel Syndrome”

2018-2020:  NHMRC Project Grant #APP1140297.  (AUD $720,585.00). Chief Investigators: A/Prof Stuart M Brierley, Prof David Grundy, Prof Nick Spencer. “Is overactive bladder a 'Bladder itch'? Identification of itch specific pathways within the bladder?”

2015-2018: NHMRC Project Grant APP#1083480. (AUS$873,233). Chief Investigators. A/Prof Stuart M Brierley, Dr Daniel Poole, Prof Martin Steinhoff. "Is abdominal discomfort a colonic itch?"

2014-2017: NHMRC Project Grant APP#1063803 (AUS$660,558). Chief Investigators: Prof Paul Alewood, Dr Stuart M Brierley. "Stable oxytocin analogues - potential treatment for irritable bowel syndrome"

2013-2016: Dr Stuart M. Brierley, NHMRC R.D Wright Fellowship (Level 1). APP1052340 (AUD $397,724). “Determining mechanisms and treatments for chronic visceral pain”. 

2013-2015: NHMRC Project Grant #APP1049928. (AUS $665,267.85). Chief Investigators: Prof David Adams, Dr Stuart M Brierley, Prof David Craik. "GABA(B) Receptor Modulation of Gastrointestinal Function in Health and Disease by Alpha-Conotoxins"

2013-2015: NHMRC Project Grant #APP1049682. (AUS $351,173.55). Chief Investigators: Prof Nigel Bunnett, Dr Graeme Cottrell, Dr Stuart M Brierley. "Mechanisms of protease-driven visceral pain"

2012-2014: NHMRC Project Grant #APP1023972. (AUS $603,375). Chief Investigators: A/Prof Amanda Page, Prof L. Ashley Blackshaw, Prof Gary Wittert, Dr Stuart M. Brierley. "The role of adipokines in modulation of gastric vagal afferent satiety signals".

2011-2013: NHMRC Project Grant #APP1008100. (AUS $436,299). Chief Investigators: Dr Stuart M. Brierley, Prof L. Ashley Blackshaw, A/Prof Grigori Y. Rychkov. "Ion channels underlying inflammatory and post-inflammatory visceral mechanical hypersensitivity"

2010-2012: NHMRC Project Grant #626960. (AUS $548,026). Chief Investigators: Dr Stuart M. Brierley, Prof L. Ashley Blackshaw, Prof Gerald Holtmann. "Viscerosensory neuroimmune interactions".

2008-2012: Dr Stuart M. Brierley, NHMRC Australian Biomedical “Peter Doherty” Fellowship.  (APP497803) “Interaction of TRP channels and inflammatory mediators: A critical role in visceral pain”. (AUD $274,000).

2008-2010: NHMRC Project Grant #508103. (AUS $641,000). Chief Investigators: Prof L. Ashley Blackshaw, Dr Stuart M. Brierley, Dr Grigori Y. Rychkov, Prof Gerald Holtmann. "Transient receptor potential channels (TRPs) as transducers and targets in primary visceral afferents".

2006-2008: NHMRC Project Grant #399324. (AUS $602,250). Chief Investigators: Prof L. Ashley Blackshaw, Prof Simon Brookes, Dr Stuart M. Brierley, Dr Amanda J Page. "How does inflammation of the gut change its sensory innervation?"

2004-2006: NHMRC Project Grant #298942. (AUS $249,750). Chief Investigators: A/Prof L. Ashley Blackshaw, Dr Amanda J Page, Dr Stuart M. Brierley. "Mechanisms of mechanotransduction in primary visceral afferents".

Date Role Research Topic Program Degree Type Student Load Student Name
2016 - 2022 Principal Supervisor The Role of Itch-Mediating Receptors and Channels in the Mouse Urinary Bladder Doctor of Philosophy Doctorate Full Time Ashlee Megan Caldwell
2015 - 2019 Principal Supervisor Role of Voltage-gated Sodium Channel Isoforms in Electrophysiological Properties of Neurons Innervating the Viscera in Mice Doctor of Philosophy Doctorate Full Time Ms Andelain Erickson

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