Stuart Brierley
School of Biomedicine
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Prof Stuart Brierley is Director of the Visceral Pain Research Group, Director of the Hopwood Centre for Neurobiology, and Co-Theme leader of the Lifelong Health theme at the South Australian Health and Medical Research Institute (SAHMRI). He is an NHMRC Investigator L1 recipient (2022-26) and received an NHMRC Research Excellence Award for being the top ranked NHMRC CDFII fellow in the 2016 round. He is an international expert in the ‘gut-brain axis’ and chronic visceral pain mechanisms. His research comprises discovery and translational science investigating the nerve pathways innervating visceral organs to determine the causes of, and treatments for, Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD), bladder pain syndrome and endometriosis. His research focuses on the role of different nerve pathways innervating the viscera, the channels and receptors underlying their function, the influence of the immune system, and how these mechanisms are changed during acute and chronic visceral pain.
Prof Brierley has a strong track record in coordinating and working in multi-faceted research programs for high-impact publications in journals such as Nature (x3), Cell, Nature Communications, Gastroenterology (x6), Gut (x10), PNAS, JCI Insight (x3), Pain (x10), J Neuroscience (x2), and has invited reviews in Nature Reviews Gastroenterology Hepatology (x2), Annual Reviews of Physiology, Trends in Pharmacological Sciences, and Trends in Biomedical Sciences.
Prof Brierley has been awarded 4 NHMRC Fellowships (Investigator, CDF II; CDF I; Peter Doherty ECF), is CIA on an NHMRC Development Grant (2022-24). He has been CI on 13 NHMRC Project grants (since 2004), two recently completed NIH grants (as part of the HEAL/SPARC scheme) and two ARC Discovery grants.
He also has a strong track record of industry collaboration. His recent collaborations with Industry partners identified the mechanism of pain relief of a new drug, linaclotide, in treating patient with Irritable Bowel Syndrome with Constipation (IBS-C). Linaclotide, a guanylate cyclase-C (GC-C) agonist is effective in relieving abdominal pain associated with IBS-C and is already available and registered for use by IBS-C patients in the USA and Europe.
Email: stuart.brierley@sahmri.com
Research Interests
MOLECULAR MECHANISMS OF ABDOMINAL PAIN: CAUSES AND CURES.
For most people pain normally serves as an alarm that is activated in response to tissue damage. However, for people who suffer from chronic or long term pain, it does not subside and can in fact worsen over time. Clinically, chronic pain is a major unresolved worldwide problem.
A/Prof Brierley's research focuses on pain arising from the gut with particular emphasis on Irritable Bowel Syndrome (IBS). In Australia IBS effects up to 15% of the population and although chronic pain is debilitating and significantly reduces a patient's quality of life there is no effective treatment. This research determines the mechanisms responsible for detecting painful events in the gut and how they change during acute and chronic conditions. It is clear that certain mechanisms are reprogrammed during chronic pain, which fail to "reset" back to normal. Overall, understanding how these mechanisms are changed is the first step in finding new therapeutic treatments for gut based pain.
Key aspects of gut based pain are discussed in Prof Brierley’s talk at the “Research Tuesday” free public seminar series at the University of Adelaide. Please see link below.
http://blogs.adelaide.edu.au/researchtuesdays/2012/01/19/get-your-stomach-in-mint-condition/
https://www.youtube.com/watch?v=D6_jjEPLKe4
https://www.youtube.com/watch?v=wqvjPAR4Xhc
Teaching Interests
RESEARCH OPPORTUNITIES ARE CURRENTLY AVAILABLE FOR MOTIVATED, OUTSTANDING APPLICANTS FOR HONOURS, MSC AND PHD POSITIONS:
1) TRP channels: Critical targets for the treatment of chronic visceral pain.
This project will investigate TRP channels in colonic sensory neurons, determine their mechano and chemosensory properties, and how their function changes across acute and chronic pain models. We will determine how TRP expression is altered in tissue from human patients with chronic visceral, thereby linking TRP levels with symptoms. Project funded by NHMRC Australia.
2) Other Projects: Several additional projects are available that we are happy to discuss with potential HDR students. These projects focus on other pain targets and are also funded by NHMRC Australia. Contact: stuart.brierley@adelaide.edu.au for details.
Techniques that students will perform include: electrophysiological afferent fibre recordings, patch clamp recordings, neuronal labeling, laser capture microdissection, QRT-PCR, tissue collection.
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Appointments
Date Position Institution name 2023 - ongoing Co-Theme leader of the Lifelong Health theme SAHMRI 2023 - ongoing Director of the Visceral Pain Research Group SAHMRI 2022 - ongoing NHMRC Investigator Leadership Fellow SAHMRI 2020 - ongoing Director of the Hopwood Centre for Neurobiology SAHMRI 2019 - 2023 Professor Flinders University 2017 - 2021 NHMRC R.D. Wright Biomedical Fellow (CDF II) Flinders University 2015 - ongoing Associate Professor University of Adelaide 2013 - 2016 NHMRC R.D. Wright Biomedical Fellow (CDF 1) University of Adelaide 2008 - 2012 NHMRC Australian Biomedical “Peter Doherty” Fellowship University of Adelaide -
Awards and Achievements
Date Type Title Institution Name Country Amount 2020 Distinction President Australasian Neurogastroenterology and Motility Association (ANGMA). Australia - -
Education
Date Institution name Country Title University of Adelaide Australia PhD
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Journals
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Books
Year Citation 2023 Brierley, S. M., & Spencer, N. J. (2023). Visceral Pain. S. M. Brierley, & N. J. Spencer (Eds.), Springer International Publishing.
DOI2022 Spencer, N. J., Costa, M., & Brierley, S. M. (Eds.) (2022). The Enteric Nervous System II. Springer International Publishing.
DOI2022 Spencer, N. J., Costa, M., & Brierley, S. M. (2022). Preface (Vol. 1383). 2016 Costa, M., & Brierley, S. (Eds.) (2016). The Enteric Nervous System. Springer International Publishing.
DOI2016 Costa, M., & Brierley, S. (Eds.) (2016). The Enteric Nervous System. Springer International Publishing.
DOI2016 Brierley, S., & Costa, M. (Eds.) (2016). Introduction to the ENS II 2014, 30 years later (Vol. 891). SPRINGER INT PUBLISHING AG. 2016 Brierley, S., & Costa, M. (Eds.) (2016). Introduction to the ENS II 2014, 30 years later (Vol. 891). SPRINGER INT PUBLISHING AG. -
Book Chapters
Year Citation 2023 Maddern, J., Brierley, S. M., & Castro, J. (2023). Pre-clinical Models of Endometriosis: A Focus on Chronic Pain. In Visceral Pain (pp. 209-222). Springer International Publishing.
DOI2019 Brierley, S. M., Grundy, D., & Grundy, L. (2019). Gastrointestinal Sensation; General Principles. In Encyclopedia of Gastroenterology, Second Edition (pp. 701-710). Elsevier.
DOI2018 Harrington, A. M., Castro, J., Erickson, A., Grundy, L., & Brierley, S. M. (2018). Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract in Health and Disease. In H. M. Said (Ed.), Physiology of the Gastrointestinal Tract: Sixth Edition (Vol. 1-2, pp. 387-418). United Kingdom: Academic Press.
DOI Scopus212016 Brierley, S. (2016). Altered ion channel/receptor expression and function in extrinsic sensory neurons: The cause of and solution to chronic visceral pain?. In S. Brierley, & M. Costa (Eds.), The Enteric Nervous System 30 Years Later (Vol. 891, pp. 75-90). Switzerland AG: SPRINGER INTERNATIONAL PUBLISHING AG.
DOI Scopus10 WoS9 Europe PMC72012 Brierley, S., Hughes, P., Harrington, A., & Blackshaw, L. (2012). Innervation of the gastrointestinal tract by spinal and vagal afferent nerves. In L. Johnson, F. Ghishan, J. Kaunitz, J. Merchant, H. Said, & J. Wood (Eds.), Physiology of the Gastrointestinal Tract, Volume 1, Fifth Edition (Vol. 1, 5 ed., pp. 703-729). United Kingdom: Elsevier.
DOI Scopus162012 Hughes, P., Brierley, S., Castro Kraftchenko, J., Harrington, A., & Blackshaw, L. (2012). Experimental colitis models. In A. Szallasi, & T. Biro (Eds.), Methods in Pharmacology and Toxicology: TRP Channels in Drug Discovery, Volume II (Vol. 2, 1 ed., pp. 379-390). USA: Springer.
DOI Scopus12012 Brierley, S. M., Hughes, P., Harrington, A., & Blackshaw, L. A. (2012). Innervation of the Gastrointestinal Tract by Spinal and Vagal Afferent Nerves. In Physiology of the Gastrointestinal Tract, Two Volume Set (pp. 703-731).
DOI Scopus22007 Brierley, S., & Blackshaw, L. (2007). The neurobiology of visceral nociceptors. In P. Pasricha, W. Willis, & G. Gebhart (Eds.), Chronic abdominal and visceral pain: theory and practice (pp. 45-66). New York: Informa.
Scopus72003 Brierley, S., Coldwell, J., Isaacs, N., Howarth, G., & Blackshaw, L. (2003). Colonic spinal primary afferents: mechanosensory and chemosensory subtypes and effects of inflammation. In G. Holtmann, & N. Talley (Eds.), Falk Symposium 130 - Gastrointestinal inflammation and disturbed gut function - the challenge of new concepts (Vol. 130, pp. 120-125). PO Box 17, 3300AA Dordrecht, The Netherlands: Kluwer Academic Publishers. -
Conference Papers
Year Citation 2021 Harrington, A., Wang, Q., Hannig, G., & Brierley, S. (2021). COLORECTAL NOCICEPTIVE PROCESSING IN THE ROSTRAL VENTROMEDIAL AND CAUDAL VENTROLATERAL MEDULLA IS INCREASED IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY AND IS REVERSED BY CHRONIC LINACLOTIDE TREATMENT. In GASTROENTEROLOGY Vol. 160 (pp. S630). ELECTR NETWORK: W B SAUNDERS CO-ELSEVIER INC. 2021 Castro, J., Maddern, J., Garcia-Caraballo, S., Schober, G., Lindstrom, B., Schmiel, S., & Brierley, S. (2021). CANNABINOID RECEPTOR 2 (CB<sub>2</sub>) LOCALIZATION IN COLONIC TISSUE AND PRIMARY SENSORY DORSAL ROOT GANGLIA (DRG) NEURONS ISOLATED FROM RODENTS WITH COLITIS AND CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 160 (pp. S503-S504). ELECTR NETWORK: W B SAUNDERS CO-ELSEVIER INC. 2020 Castro, J., Maddern, J., Garcia-Caraballo, S., Schober, G., Lindstrom, B., Schmiel, S., & Brierley, S. (2020). CANNABINOID RECEPTOR EXPRESSION AND THE EFFECT OF OLORINAB, A PERIPHERALLY ACTING, HIGHLY SELECTIVE, FULL AGONIST OF THE CANNABINOID RECEPTOR 2 (CB<sub>2</sub>), IN RODENTS WITH COLITIS AND CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 158 (pp. S269). Austin, TX: W B SAUNDERS CO-ELSEVIER INC. 2020 Castro, J., Maddern, J., Erickson, A., & Brierley, S. (2020). Co-morbidities of IBS: Role of voltage-gated sodium channels in mouse vaginal afferent mechanosensation and pain. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 32 (pp. 1 page). WILEY. 2020 Harrington, A., Garcia-Caraballo, S., Grundy, L., Castro, J., Hannig, G., & Brierley, S. (2020). CHRONIC INTRA-COLONIC LINACLOTIDE ADMINISTRATION ALTERS GLIAL ACTIVATION IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 158 (pp. S803). Austin, TX: W B SAUNDERS CO-ELSEVIER INC.
WoS12019 Castro, J., Maddern, J., Garcia-Caraballo, S., Lumsden, A. L., Lindstrom, B., Adams, J., & Brierley, S. (2019). OLORINAB (FORMERLY APD371), A PERIPHERALLY RESTRICTED, HIGHLY SELECTIVE, FULL AGONIST OF THE CANNABINOID RECEPTOR 2 (CB<sub>2</sub>), REDUCES VISCERAL HYPERSENSITIVITY IN ANIMAL MODELS. In GASTROENTEROLOGY Vol. 156 (pp. S382). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
WoS42019 Castro, J., Maddern, J., Garcia-Caraballo, S., Lumsden, A., Lindstrom, B., Adams, J., & Brierley, S. M. (2019). Olorinab (APD371), a peripherally restricted, highly selective, full agonist of the cannabinoid receptor type 2 (CB<sub>2</sub>), reduces visceral hypersensitivity in animal models. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 31 (pp. 2 pages). WILEY. 2019 Castro, J., Harrington, A., Maddern, J., Schober, G., Grundy, L. A., Ge, P., . . . Brierley, S. (2019). CHRONIC INTRACOLONIC ADMINISTRATION OF LINACLOTIDE INHIBITS NOCICEPTIVE SIGNALING IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 156 (pp. S570). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
WoS22019 Grundy, L., Castro, J., Maddern, J., Harrington, A., Hannig, G., Ge, P., & Brierley, S. (2019). CHRONIC COLONIC ADMINISTRATION OF THE GUANYLATE CYCLASE-C AGONIST LINACLOTIDE ATTENUATES COLITIS INDUCED BLADDER AFFERENT HYPERACTIVITY. In GASTROENTEROLOGY Vol. 156 (pp. S363). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
WoS12018 Brierley, S., Castro, J., Maddern, J., Garcia-Caraballo, S., Lindstrom, B., & Adams, J. (2018). APD371, a peripherally restricted, highly selective, full agonist of the Cannabinoid Receptor 2 (CB2), reduces colitis-induced visceral hypersensitivity in rats. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 2 pages). WILEY. 2018 Uhlig, F., Grundy, L., Castro, J., Brierley, S. M., Foster, S. J., & Grundy, D. (2018). Identification of modulators of intestinal nerve activity from <i>Staphylococcus aureus</i>. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY. 2018 Erickson, A., Garcia-Caraballo, S., Castro, J., Grundy, L., Rychkov, G., Vetter, I., . . . Brierley, S. (2018). Role of voltage-gated sodium channel isoforms in colon-innervating neurons in mice. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY. 2018 Grundy, L., Castro, J., Harrington, A., Garcia-Caraballo, S., Maddern, J., Rychkov, G., & Brierley, S. (2018). Colitis-induced chronic colonic hypersensitivity induces cross organ sensitisation of bladder afferent pathways. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY.
WoS12017 Grundy, L. A., Castro, J., Harrington, A., Peters, S., Feil, R., Miller, P., . . . Brierley, S. (2017). EXTRACELLULAR CGMP REDUCES THE EXCITABILITY OF SENSORY DORSAL ROOT GANGLION NEURONS VIA AN EXTRACELLULAR MECHANISM. In GASTROENTEROLOGY Vol. 152 (pp. S156). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
DOI WoS12015 Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., . . . Brierley, S. M. (2015). A Visceral Representation of Itch: Identification 'Itch-Specific' Pruritogenic Mechanisms Within Colonic Sensory Pathways. In GASTROENTEROLOGY Vol. 148 (pp. S733). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. 2015 Harrington, A. M., Castro, J., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., Grundy, L., . . . Brierley, S. M. (2015). GC-C Agonists As Regulators of Visceral Sensation: Modulation of Mucosal Sensitivity via the Epithelial GC-C/cGMP Pathway. In GASTROENTEROLOGY Vol. 148 (pp. S732-S733). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. 2015 Castro, J., Harrington, A. M., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., Grundy, L., . . . Brierley, S. M. (2015). Chronic Activation of the GC-C/cGMP Pathway by Linaclotide Inhibits Ascending Nociceptive Pathways and Restores Aberrant Spinal Cord Signaling. In GASTROENTEROLOGY Vol. 148 (pp. S194). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. 2014 Castro, J., Rychkov, G. Y., Ghetti, A., Harrington, A. M., Kurtz, C. B., Silos-Santiago, I., & Brierley, S. M. (2014). Extracellular Cyclic GMP (cGMP), the Downstream Mediator Released in Response to Linaclotide-Induced Activation of Guanylate Cyclase-C (GC-C), Reduces Excitability of Murine and Human Dorsal Root Ganglion (DRG) Neurons. In GASTROENTEROLOGY Vol. 146 (pp. S722). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. 2014 Harrington, A. M., Castro, J., Garcia-Caraballo, S., Maddern, J., Craik, D., Adams, D. J., & Brierley, S. M. (2014). α-Conotoxin Vc1.1 Targets GABAB Receptors Modulating CaV2.2 and CaV2.3 Calcium Channels in Sensory Pathways Mediating Chronic Visceral Pain. In GASTROENTEROLOGY Vol. 146 (pp. S156). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. 2013 Castro, J., Harrington, A. M., Mann, E. A., Cohen, M. B., Kurtz, C. B., Silos-Santiago, A., & Brierley, S. M. (2013). Mechanisms Underlying Linaclotide Induced Inhibition of Colonic Nociception. In GASTROENTEROLOGY Vol. 144 (pp. S134). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC. 2013 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C. B., Silos-Santiago, A., Nguyen, N. Q., . . . Brierley, S. M. (2013). Alterations in the Guanylate Cyclase-C/cGMP Pathway in Patients With Irritable Bowel Syndrome With Constipation. In GASTROENTEROLOGY Vol. 144 (pp. S59-S60). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC. 2013 Hughes, P. A., Harrington, A. M., Castro, J., Isaacs, N. J., Moretta, M., Hicks, G. A., . . . Brierley, S. M. (2013). Increased Efficacy of the Peripherally-Restricted Selective Kappa-Opioid Receptor Agonist, Asimadoline, in Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 144 (pp. S934-S935). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC. 2012 Hughes, P. A., Isaacs, N. J., Moretta, M., Hicks, G. A., Urso, D. M., Blackshaw, L. A., & Brierley, S. M. (2012). Identification of Kappa Opioid Receptors on Colonic Sensory Nerves and Their Up-Regulation in a Mouse Model of Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S702). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. 2012 Castro, J., Harrington, A. M., Hughes, P. A., Martin, C., Silos-Santiago, A., Kurtz, C. B., . . . Brierley, S. M. (2012). Mechanism of Action for Linaclotide Induced Abdominal Pain Relief. In GASTROENTEROLOGY Vol. 142 (pp. S699). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
WoS52012 Harrington, A. M., Brierley, S. M., Castro, J., Isaacs, N. J., & Blackshaw, L. A. (2012). Characterization of Dorsal Horn Neurons Activated by Noxious Colorectal Distension in Health and Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S699). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. 2012 Castro, J., Harrington, A. M., Page, A. J., & Brierley, S. M. (2012). Downstream Signaling Pathways of Nitric Oxide Induced Modulation of Colonic Afferent Mechanosensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S697). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. 2011 Castro, J., Martin, C., Hughes, P. A., Silos-Santiago, A., Kurtz, C. B., Blackshaw, L. A., & Brierley, S. M. (2011). A Novel Role of Cyclic GMP in Colonic Sensory Neurotransmission in Healthy and TNBS-Treated Mice. In GASTROENTEROLOGY Vol. 140 (pp. S538). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
WoS182011 Castro, J., Harrington, A., Hughes, P. A., Martin, C., Page, A. J., Blackshaw, L. A., & Brierley, S. M. (2011). Nitric Oxide Mechanism of Action on Visceral Nociceptors. In GASTROENTEROLOGY Vol. 140 (pp. S536). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. 2011 Adam, B., Liebregts, T., Bredack, C., Brierley, S. M., Hughes, P. A., Blackshaw, L. A., . . . Holtmann, G. (2011). Small Bowel Homing T Cells Are Associated With Symptoms and Delayed Gastric Emptying in Functional Dyspepsia. In GASTROENTEROLOGY Vol. 140 (pp. S139). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. 2011 Harrington, A., Brierley, S. M., Castro, J., Hughes, P. A., & Blackshaw, L. A. (2011). Identification of Colonic Afferent Central Terminals and Changes Following Colonic Inflammation. In GASTROENTEROLOGY Vol. 140 (pp. S131). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. 2011 Castro, J., Balemba, O. B., Blackshaw, L. A., & Brierley, S. M. (2011). Garcinia Buchananii Bark Extract Inhibits Nociceptors, With Greater Efficacy During Inflammation. In GASTROENTEROLOGY Vol. 140 (pp. S866). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
WoS72011 Balemba, O. B., Boakye, P. A., Brierley, S. M., & Pasilis, S. P. (2011). Garcinia Buchananii Bark Extract is an Effective Anti-Diarrheal Remedy. In GASTROENTEROLOGY Vol. 140 (pp. S284). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
WoS12010 Hughes, P., Brierley, S., Harrington, A., Castro, J., Martin, C., & Blackshaw, L. (2010). Differential coupling of cytokine receptors to sensory neurons in health and post inflammation. In Proceedings Vol. 138 (pp. 136-137). W B SAUNDERS CO-ELSEVIER INC.
DOI2010 Harrington, A., Young, R., Brierley, S., & Blackshaw, L. (2010). TRPV1 mediates acid activation of esophageal sensory pathways. In Proceedings of 2010 Joint International Neurogastroenterology and Motility Meeting, NGM 2010 Vol. 22 (pp. 55). UK: Wiley-Blackwell Publishing Ltd. 2009 Harrington, A., Hughes, P., Martin, C., Isaacs, N., Brierley, S., & Blackshaw, L. (2009). Localisation and function of transient receptor potential ion channel melastatin subtype 8 (TRPM8) in mouse colonic primary afferent nerve fibers. In Autonomic neuroscience Vol. 149 (pp. 29). United States: Elsevier B.V..
DOI2009 Brierley, S., Harrington, A., Hughes, P., Page, A., Corey, D., Kwan, K., . . . Blackshaw, L. (2009). TRPA1 contributes to specific mechanotransduction currents in isolated DRG neurons. In TRP Channels: From Sensory Signaling to Human Disease (pp. 76). Stockholm, Sweden. 2009 Hughes, P. A., Brierley, S. M., Persson, J., Liebregts, T., Adam, B., Holtmann, G., & Blackshaw, L. A. (2009). Immune Cell Supernatants from IBS Patient Subtypes Differentially Affect Visceral Afferent Mechanosensitivity. In GASTROENTEROLOGY Vol. 136 (pp. A75). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. 2008 Hughes, P. A., Brierley, S. M., Liebregts, T., Adam, B., Holtmann, G. J., & Blackshaw, L. A. (2008). Sensitization of visceral afferents by immune cell supernatants from IBS patients. In GASTROENTEROLOGY Vol. 134 (pp. A553). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. 2008 Hughes, P. A., Brierley, S. M., & Blackshaw, L. A. (2008). Delayed post-inflammatory hypersensitivity in sub-populations of colonic afferents. In GASTROENTEROLOGY Vol. 134 (pp. A553). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. 2008 Brierley, S. M., Hughes, P. A., Page, A. J., O'Donnell, T. A., Martin, C. M., Kwan, K. Y., . . . Blackshaw, L. A. (2008). Novel and specific roles for the ion channel TRPA1 in visceral sensory transduction. In GASTROENTEROLOGY Vol. 134 (pp. A8). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
WoS42008 Liebregts, T., Junne, J. G., Adam, B., Brierley, S. M., Blackshaw, L. A., Gerken, G., & Holtmann, G. J. (2008). Impaired steroid sensitivity of peripheral blood mononuclear cells in patients with irritable bowel syndrome. In GASTROENTEROLOGY Vol. 134 (pp. A689). W B SAUNDERS CO-ELSEVIER INC. 2008 Adam, B., Liebregts, T., Brierley, S. M., Blackshaw, L. A., & Holtmann, G. J. (2008). Small bowel homing T lymphocytes and symptom severity in patients with functional dyspepsia. In GASTROENTEROLOGY Vol. 134 (pp. A690). W B SAUNDERS CO-ELSEVIER INC. 2008 Page, A. J., O'Donnell, T. A., Koch, L., Brierley, S. M., & Blackshaw, L. A. (2008). Switching of leptin effects on peripheral vagal afferent mechanosensitivity with feeding and fasting. In GASTROENTEROLOGY Vol. 134 (pp. A97). W B SAUNDERS CO-ELSEVIER INC. 2008 Sutherland, K., Brierley, S. M., Rayner, C., Horowitz, M., Blackshaw, L. A., & Young, R. L. (2008). Altered duodenal sweet taste receptor expression in diabetic hyperglycemia. In GASTROENTEROLOGY Vol. 134 (pp. A44). W B SAUNDERS CO-ELSEVIER INC. 2007 Sutherland, K., Brierley, S. M., Horowitz, M., Rayner, C., Blackshaw, L. A., & Young, R. L. (2007). Sweet taste transduction molecules are expressed in the upper gastrointestinal tract in humans. In GASTROENTEROLOGY Vol. 132 (pp. A587). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
WoS32007 Sipe, W. E., Vergnolle, N., Phillis, B. D., Brierley, S. M., Martin, C. M., Blackshaw, L. A., & Bunnett, N. W. (2007). Transient receptor potential vanilloid 4 (TRPV4) mediates inflammation-induced sensitization of colonic afferent nerves and mechanical hyperalgesia. In GASTROENTEROLOGY Vol. 132 (pp. A599). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. 2007 Adam, B., Liebregts, T., Bredack, C., Brierley, S. M., Pilkington, K. R., Junne, J. G., . . . Holtmann, G. (2007). Gut homing properties of circulating T cells in patients with irritable bowel syndrome (IBS). In GASTROENTEROLOGY Vol. 132 (pp. A388). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. 2007 Liebregts, T., Adam, B., Bredack, C., Lester, S., Dowme-doyle, S., Brierley, S. M., . . . Holtmann, G. (2007). CTLA-4 haplotypes and Cd4+Cd25+Foxp3+ regulatory T cells in irritable bowel syndrome. In GASTROENTEROLOGY Vol. 132 (pp. A137). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. 2007 Brierley, S. M., Hughes, P. A., Page, A. J., & Blackshaw, L. A. (2007). Mechanical hypersensitivity of mouse colonic afferents after activation of the ion channel Trpa1. In GASTROENTEROLOGY Vol. 132 (pp. A600). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. 2007 Brierley, S. M., Hughes, P. A., Page, A. J., Adam, B., Liebregts, T., Holtmann, G., . . . Blackshaw, L. (2007). Mice lacking the TRPV4 ion channel display major deficits in spinal colonic but not vagal gastroesophageal mechanosensory function. In GASTROENTEROLOGY Vol. 132 (pp. A156). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
WoS22007 Pezos, N., Sutherland, K., Brierley, S. M., Horowitz, M., Blackshaw, L. A., & Young, R. L. (2007). Vagal afferents do not directly detect intestinal glucose via a sweet-taste mechanism. In GASTROENTEROLOGY Vol. 132 (pp. A587). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. 2007 Jensen, J., Branden, L., Brierley, S. M., Cooper, N. J., Green, M., Ahlefelt, M., . . . Blackshaw, L. A. (2007). Modulation of visceral afferents by large conductance KCA channels. In GASTROENTEROLOGY Vol. 132 (pp. A126). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. 2006 Page, A. J., Slattery, J., O'Donnell, T. A., Brierley, S., Milte, C., Laker, R., & Blackshaw, L. A. (2006). Ghrelin reduces mechanical sensitivity of gastroesophageal vagal afferents in ferrets and mice. In GASTROENTEROLOGY Vol. 130 (pp. A228). Los Angeles, CA: W B SAUNDERS CO-ELSEVIER INC. 2005 Brierley, S. M., Price, M. P., Wemmie, J. A., Welsh, M. J., & Blackshaw, L. A. (2005). ASIC1, 2 & 3 contribute differently to colonic serosal & mesenteric mechanoreceptor function. In GASTROENTEROLOGY Vol. 128 (pp. A124-A125). Chicago, IL: W B SAUNDERS CO. 2003 Brierley, S. M., Wemmie, J. A., Welsh, M. J., & Blackshaw, L. A. (2003). ASIC ion channels contribute to colonic mechanosensory function in mice. In GASTROENTEROLOGY Vol. 124 (pp. A39). ORLANDO, FLORIDA: W B SAUNDERS CO.
DOI2002 Brierley, S., Cooper, N., & Blackshaw, L. A. (2002). Pelvic colonic primary afferents: Mechanosensory and pharmacological subtypes. In GASTROENTEROLOGY Vol. 122 (pp. A527). W B SAUNDERS CO.
WoS32002 Coldwell, J. R., Brierley, S. M., Cooper, N. J., & Blackshaw, L. A. (2002). Structural and functional aspects of mechanoreceptor endings in rat colon. In JOURNAL OF PHYSIOLOGY-LONDON Vol. 543 (pp. 4P-5P). UNIV LIVERPOOL, LIVERPOOL, ENGLAND: CAMBRIDGE UNIV PRESS. -
Conference Items
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Preprint
Year Citation 2022 Karnon, J., Afzali, H., & Bonevski, B. (2022). Should rapid antigen tests be government funded in Australia? An economic evaluation.
DOI2020 Grundy, L., Caldwell, A., Garcia-Caraballo, S., Grundy, D., Spencer, N., Dong, X., . . . Brierley, S. (2020). Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension.
DOI
Research Funding
NHMRC AUSTRALIA:
i) Current:
2022-2026: Prof Stuart M. Brierley. NHMRC Investigator (L1) Grant. “Identifying the underlying causes and discovering novel therapeutic treatments for chronic visceral pain (CVP)”. APP2008727. AUD $2,173,555.00
2022-2024: NHMRC Development Grant (APP2014250). (AUD $998,858.88). Chief Investigators: Prof Stuart M Brierley, Prof Glenn King. “Developing a first-in-class therapeutic for chronic visceral pain using venom derived peptides”
ii) Previous:
2020-2023: U01 NS113869 (SPARC/HEAL) (USD$ 2,536,899). CIs: Prof David Julius, Prof Holly Ingraham, Dr James Bayrer, Prof Stuart Brierley “Mapping gut-spinal cord connections in visceral pain”
2020-2023: U01 NS113871 (SPARC/HEAL) (USD$ 2,159,613) CIs: Prof Million Mulugeta, Prof Stuart Brierley, Prof Evgeniy Kreydin, Dr Muriel Larauche, Dr Lixin Wang, Prof Reggie Edgerton, “Structural and functional mapping of visceral pain afferent neurocircuitries of the colorectum and bladder in preclinical models”
2019-2022: NHMRC Project grant. APP1156427 (AUD $988,243). Chief Investigators: N.J. Spencer, Prof Stuart M Brierley, V. Zagorodnyuk & A Harrington. “Silencing visceral pain pathways using novel optogenetic techniques in vivo”
2018-2020: ARC Discovery Project: DP180101395. (AUS$331,000). Chief Investigators: Dr Andrea Harrington, A/Prof Stuart M. Brierley, A/Prof Stuart Mazzone, A/Prof Grigori Rychkov. “Central pathways regulating visceral pain”
2017-2020: A/Prof Stuart M. Brierley, NHMRC R.D Wright Fellowship (Level 2). APP1126378 (AUD $470,144).
“Identifying the underlying causes of chronic visceral pain and discovering novel therapeutic treatments”. Top ranked CDF II in the 2016 round.
2018-2020: NHMRC Project Grant APP1139366. (AUD $696,808.50). Chief Investigators: A/Prof Stuart M Brierley, Prof Richard Lewis, A/Prof Irina Vetter, A/Prof Grigori Rychkov. “Silencing visceral nociceptors by targeting NaV1.1: A novel therapeutic approach for treating Irritable Bowel Syndrome”
2018-2020: NHMRC Project Grant #APP1140297. (AUD $720,585.00). Chief Investigators: A/Prof Stuart M Brierley, Prof David Grundy, Prof Nick Spencer. “Is overactive bladder a 'Bladder itch'? Identification of itch specific pathways within the bladder?”
2015-2018: NHMRC Project Grant APP#1083480. (AUS$873,233). Chief Investigators. A/Prof Stuart M Brierley, Dr Daniel Poole, Prof Martin Steinhoff. "Is abdominal discomfort a colonic itch?"
2014-2017: NHMRC Project Grant APP#1063803 (AUS$660,558). Chief Investigators: Prof Paul Alewood, Dr Stuart M Brierley. "Stable oxytocin analogues - potential treatment for irritable bowel syndrome"
2013-2016: Dr Stuart M. Brierley, NHMRC R.D Wright Fellowship (Level 1). APP1052340 (AUD $397,724). “Determining mechanisms and treatments for chronic visceral pain”.
2013-2015: NHMRC Project Grant #APP1049928. (AUS $665,267.85). Chief Investigators: Prof David Adams, Dr Stuart M Brierley, Prof David Craik. "GABA(B) Receptor Modulation of Gastrointestinal Function in Health and Disease by Alpha-Conotoxins"
2013-2015: NHMRC Project Grant #APP1049682. (AUS $351,173.55). Chief Investigators: Prof Nigel Bunnett, Dr Graeme Cottrell, Dr Stuart M Brierley. "Mechanisms of protease-driven visceral pain"
2012-2014: NHMRC Project Grant #APP1023972. (AUS $603,375). Chief Investigators: A/Prof Amanda Page, Prof L. Ashley Blackshaw, Prof Gary Wittert, Dr Stuart M. Brierley. "The role of adipokines in modulation of gastric vagal afferent satiety signals".
2011-2013: NHMRC Project Grant #APP1008100. (AUS $436,299). Chief Investigators: Dr Stuart M. Brierley, Prof L. Ashley Blackshaw, A/Prof Grigori Y. Rychkov. "Ion channels underlying inflammatory and post-inflammatory visceral mechanical hypersensitivity"
2010-2012: NHMRC Project Grant #626960. (AUS $548,026). Chief Investigators: Dr Stuart M. Brierley, Prof L. Ashley Blackshaw, Prof Gerald Holtmann. "Viscerosensory neuroimmune interactions".
2008-2012: Dr Stuart M. Brierley, NHMRC Australian Biomedical “Peter Doherty” Fellowship. (APP497803) “Interaction of TRP channels and inflammatory mediators: A critical role in visceral pain”. (AUD $274,000).
2008-2010: NHMRC Project Grant #508103. (AUS $641,000). Chief Investigators: Prof L. Ashley Blackshaw, Dr Stuart M. Brierley, Dr Grigori Y. Rychkov, Prof Gerald Holtmann. "Transient receptor potential channels (TRPs) as transducers and targets in primary visceral afferents".
2006-2008: NHMRC Project Grant #399324. (AUS $602,250). Chief Investigators: Prof L. Ashley Blackshaw, Prof Simon Brookes, Dr Stuart M. Brierley, Dr Amanda J Page. "How does inflammation of the gut change its sensory innervation?"
2004-2006: NHMRC Project Grant #298942. (AUS $249,750). Chief Investigators: A/Prof L. Ashley Blackshaw, Dr Amanda J Page, Dr Stuart M. Brierley. "Mechanisms of mechanotransduction in primary visceral afferents".
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Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2016 - 2022 Principal Supervisor The Role of Itch-Mediating Receptors and Channels in the Mouse Urinary Bladder Doctor of Philosophy Doctorate Full Time Ashlee Megan Caldwell 2015 - 2019 Principal Supervisor Role of Voltage-gated Sodium Channel Isoforms in Electrophysiological Properties of Neurons Innervating the Viscera in Mice Doctor of Philosophy Doctorate Full Time Ms Andelain Erickson
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