School of Biological Sciences
Faculty of Sciences
Dr Stephanie Begg is a researcher in the Research Centre for Infectious Diseases, where she is investigating the role of metal ions in the virulence and viability of bacterial pathogens.
Metal ions play an integral role in the cellular chemistry of all forms of life. During bacterial infection, the human host can use both metal ion intoxication and starvation in an attempt to kill invading bacteria. As a result, human bacterial pathogens such as Streptococcus pneumoniae have evolved an extensive repertoire of molecular mechanisms to survive and thrive in conditions of metal stress. My research investigates how bacterial pathogens steal essential metals, such as manganese and zinc, from the host during metal starvation, and conversely, how the bacteria resists metal toxicity during intoxication. By gaining a thorough understanding of the molecular mechanisms used by bacteria to survive and cause disease, we will discover novel opportunities for therapeutic exploitation, and help to combat the ever-increasing rates of antibiotic resistance.
Date Position Institution name 2018 NHMRC Peter Doherty Fellow The University of Adelaide 2017 - 2017 Research Associate The University of Adelaide 2016 - 2016 Research Associate The University of South Australia 2012 - 2012 Research Assistant University of Adelaide, Adelaide
Awards and Achievements
Date Type Title Institution Name Country Amount 2017 Fellowship ASBMB Fellowship — — $2500 2017 Award University Doctoral Research Medal — — — 2017 Award ASBMB Collins Bursary — — $915 2016 Achievement Dean's Commendation for Doctoral Thesis Excellence — — — 2015 Fellowship Australian Federation of Graduate Women Barbara Hale Fellowship — — — 2014 Award Young Investigator Award — — $750 2013 Scholarship Australian Postgraduate Award — — $84,000
Date Institution name Country Title — University of Adelaide Australia Bachelor Science (Biomedical Science) — University of Adelaide Australia PhD
Year Citation 2016 McDevitt, C., Begg, S., & Paton, J. (2016). Metal ion Toxicity and Oxidative Stress in Streptococcus Pneumoniae. In F. de Burjin (Ed.), Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria (Vol. 2, pp. 1184-1193). Hoboken, NJ, USA: John Wiley & Sons, Inc..
Year Citation 2016 Pederick, V. G., Eijkelkamp, B. A., Plumptre, C. D., Harvey, R. M., Hughes, C. E., Morey, J. R., . . . McDevitt, C. A. (2016). The role of Pht proteins in pneumococcal zinc acquisition. Poster session presented at the meeting of BioMetals 2016. Dresden, Germany. 2015 Pederick, V. G., Eijkelkamp, B. A., Begg, S. L., Ween, M. P., McAllister, L. J., Paton, J. C., & McDevitt, C. A. (2015). ZnuA and zinc homeostasis in Pseudomonas aeruginosa. Poster session presented at the meeting of Abstract of BacPath 13: Molecular Analysis of Bacterial Pathogens Conference 2015. Phillip Island, VIC: BacPath & ASN Events. 2015 Pederick, V. G., Begg, S. L., eijkelkamp, B. A., ween, M. P., Paton, J. C., & McDevitt, C. A. (2015). Metal uptake transporters – a microbial Achilles heel. Poster session presented at the meeting of An exchange workshop on antimicrobial resistance. UniSA. 2013 Pederick, V. G., Eijkelkamp, B. A., Ween, M. P., Begg, S. L., Paton, J. C., & McDevitt, C. A. (2013). The role of molybdenum in Pseudomonas aeruginosa persistence. Poster session presented at the meeting of School of Molecular and Biomedical Sciences 3-Minute Thesis competition. — Young, R., Begg, S., Sumby, C., & McDevitt, C. (n.d.). Silver Coordination Polymers: Relationships between structure and antibacterial activity. Poster session presented at the meeting of Unknown Conference.
NHMRC Peter Doherty Fellowship (2018-2021)
Australian Federation of Graduate Women Barbara Hale Fellowship (2015) $8000
Laboratory Demonstrator- Masters of Biotechnology (2016)
Laboratory Demonstrator- Bachelor of Medicine/ Bachelor of Surgery Clinical Skills (2016)
Laboratory Demonstrator- Infection and Immunity (2015)
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