Dr Stephanie Begg
Dr Stephanie Begg is a researcher in the Research Centre for Infectious Diseases, where she is investigating the role of metal ions in the virulence and viability of bacterial pathogens.
Metal ions play an integral role in the cellular chemistry of all forms of life. During bacterial infection, the human host can use both metal ion intoxication and starvation in an attempt to kill invading bacteria. As a result, human bacterial pathogens such as Streptococcus pneumoniae have evolved an extensive repertoire of molecular mechanisms to survive and thrive in conditions of metal stress. My research investigates how bacterial pathogens steal essential metals, such as manganese and zinc, from the host during metal starvation, and conversely, how the bacteria resists metal toxicity during intoxication. By gaining a thorough understanding of the molecular mechanisms used by bacteria to survive and cause disease, we will discover novel opportunities for therapeutic exploitation, and help to combat the ever-increasing rates of antibiotic resistance.
|2018||NHMRC Peter Doherty Fellow||The University of Adelaide|
|2017 - 2017||Research Associate||The University of Adelaide|
|2016 - 2016||Research Associate||The University of South Australia|
|2012 - 2012||Research Assistant||University of Adelaide, Adelaide|
|2017||Award||University Doctoral Research Medal||—||—||—|
|2017||Award||ASBMB Collins Bursary||—||—||$915|
|2016||Achievement||Dean's Commendation for Doctoral Thesis Excellence||—||—||—|
|2015||Fellowship||Australian Federation of Graduate Women Barbara Hale Fellowship||—||—||—|
|2014||Award||Young Investigator Award||—||—||$750|
|2013||Scholarship||Australian Postgraduate Award||—||—||$84,000|
|—||University of Adelaide||Australia||Bachelor Science (Biomedical Science)|
|—||University of Adelaide||Australia||PhD|
|2016||McDevitt, C., Begg, S., & Paton, J. (2016). Metal ion Toxicity and Oxidative Stress in Streptococcus Pneumoniae. In F. de Burjin (Ed.), Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria (Vol. 2, pp. 1184-1193). Hoboken, NJ, USA: John Wiley & Sons, Inc..
|2016||Pederick, V. G., Eijkelkamp, B. A., Plumptre, C. D., Harvey, R. M., Hughes, C. E., Morey, J. R., . . . McDevitt, C. A. (2016). The role of Pht proteins in pneumococcal zinc acquisition. Poster session presented at the meeting of BioMetals 2016. Dresden, Germany.|
|2015||Pederick, V. G., Eijkelkamp, B. A., Begg, S. L., Ween, M. P., McAllister, L. J., Paton, J. C., & McDevitt, C. A. (2015). ZnuA and zinc homeostasis in Pseudomonas aeruginosa. Poster session presented at the meeting of Abstract of BacPath 13: Molecular Analysis of Bacterial Pathogens Conference 2015. Phillip Island, VIC: BacPath & ASN Events.|
|2015||Pederick, V. G., Begg, S. L., eijkelkamp, B. A., ween, M. P., Paton, J. C., & McDevitt, C. A. (2015). Metal uptake transporters – a microbial Achilles heel. Poster session presented at the meeting of An exchange workshop on antimicrobial resistance. UniSA.|
|2013||Pederick, V. G., Eijkelkamp, B. A., Ween, M. P., Begg, S. L., Paton, J. C., & McDevitt, C. A. (2013). The role of molybdenum in Pseudomonas aeruginosa persistence. Poster session presented at the meeting of School of Molecular and Biomedical Sciences 3-Minute Thesis competition.|
|—||Young, R., Begg, S., Sumby, C., & McDevitt, C. (n.d.). Silver Coordination Polymers: Relationships between structure and antibacterial activity. Poster session presented at the meeting of Unknown Conference.
NHMRC Peter Doherty Fellowship (2018-2021)
Australian Federation of Graduate Women Barbara Hale Fellowship (2015) $8000
Laboratory Demonstrator- Masters of Biotechnology (2016)
Laboratory Demonstrator- Bachelor of Medicine/ Bachelor of Surgery Clinical Skills (2016)
Laboratory Demonstrator- Infection and Immunity (2015)
|2015 - ongoing||Member||UK Biochemical Society||—|
|2014 - ongoing||Board Member||Adelaide Protein Group||—|
|2014 - ongoing||Member||Australian Society for Biochemistry and Molecular Biology||—|
|2013 - 2015||Member||Australian Society for Microbiology||—|