Lymphatic vessels represent a critical but underappreciated component of the circulatory system. They regulate tissue and organ function via numerous mechanisms, most notably, through the maintenance of fluid balance and the trafficking of immune cells. Impaired lymphatic function results in lymphoedema; a debilitating condition characterised by chronic fluid accumulation and swelling of the extremities. There is also a growing appreciation for the involvement of lymphatic vessel remodelling in other diseases, such as cancers and cardiovascular pathologies. My research seeks to uncover the fundamental mechanisms that control how lymphatic vessels develop. In particular, I am interested in identifying how transcription factors activate gene expression programs that regulate lymphatic endothelial cell identity and function.