Dr Simran Sidhu
Senior Lecturer
School of Biomedicine
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Simran Sidhu is a Senior Lecturer in the Discipline of Physiology and leader of the Integrative Human Neurophysiology Laboratory in the Adelaide Medical School, Faculty of Health and Medical Sciences.
Dr Sidhu was awarded her PhD in Neuroscience (School of Human Movement Studies, The University of Queensland, Australia) in 2012. She completed her postdoctoral fellowship in Integrative Physiology at The University of Utah, Salt Lake City, USA (2013-2015) and during this time was also awarded the American Heart Association Fellowship (2014-2015). Dr Sidhu was appointed Lecturer in the Discipline of Physiology at The University of Adelaide in June 2015.
Dr Sidhu's research bridges three disciplines: neuroscience, physiology, and exercise science – with a focus on elucidating neurophysiological mechanisms of exercise intolerance. Her research involves the application of non-invasive neurophysiological tools at the cutting edge of integrative neurophysiology, for e.g. Transcranial Magnetic Stimulation (TMS) and transcranial direct current stimulation (tDCS) in healthy, aged, and clinical populations.
- My Research
- Career
- Publications
- Grants and Funding
- Teaching
- Supervision
- Professional Activities
- Contact
Current projects available for research students in my laboratory:
Overarching background to the available projects:
A hallmark of people with neurological and cardiovascular conditions such as multiple sclerosis and heart failure is premature fatigue, which not only impairs their quality of life, but also depicts a major source of morbidity. In advancing age, exercise intolerance and disability remains high. We understand little about the brain areas involved in the development of fatigue, and the impact of centrally driven fatigue on movements that are vital for interaction with our environment. Having a detailed understanding of the neural mechanisms and interactions that occur between the components in the brain during physical activity is critical to establish the anatomical sites of intervention that will reduce the effects of fatigue and increase movement tolerance. Furthermore, in many social and economic contexts, including vehicle driving, manual industrial operations and defence, physical fatigue has important influence on cognitive performance during goal directed movements. To improve human work productivity in health and disease, both the neurophysiological and psychophysical aspects of fatigue need to be addressed.
The series of projects currently implemented in my lab (details below) allow us to address the overarching aim of gaining a deep understanding of the relationship between exercise-related fatigue and physical activity, neural correlates, and motor-cognitive performance in humans.
Project 1:
- Title: Brain mechanisms underlying effects of exercise-related fatigue on physical and motor-cognitive performance.
- Available for: Third-year research placement students/Honours/PhD/Masters
- Location: Helen Mayo South
- Research project availability: Semester 1/2
Project 2:
- Title: Neuromodulation, Neural fatigue and physical activity in multiple sclerosis.
- Available for: Honours/PhD/Masters
- Location: Helen Mayo South
- Research project availability: Semester 1/2
Project 3:
- Title: Age-related impact of physical activity on the brain.
- Available for: Honours/PhD/Masters
- Location: Helen Mayo South
- Research project availability: Semester 1/2
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Appointments
Date Position Institution name 2019 - ongoing Senior Lecturer University of Adelaide 2015 - 2018 Lecturer University of Adelaide 2012 - 2015 Postdoctoral Fellow University of Utah -
Awards and Achievements
Date Type Title Institution Name Country Amount 2022 Fellowship Fellow - Higher Education Academy (FHEA) Advance HE United Kingdom - 2018 Award 2018 Women's Research Excellence Award The University of Adelaide Australia 5000 2016 Recognition American Physiological Society (APS) select award for distinction in scholarship American Physiological Society (APS) United States - 2014 Award American Heart Association Fellowship Award The University of Utah United States - 2012 Honour Warren Walsh Memorial Award for outstanding academic performance during doctoral studies The University of Queensland Australia - 2007 Achievement Class I Honours In Physiology The University of New South Wales Australia - -
Education
Date Institution name Country Title 2009 - 2012 University of Queensland Australia PhD (Neuroscience/Neurophysiology) 2007 University of New South Wales Australia BSc Hons 1 (Exercise Neurophysiology) 2003 - 2006 National University of Singapore Singapore BSc (Biomedical Science) -
Postgraduate Training
Date Title Institution Country 2012 - 2015 Postdoctoral Fellowship (American Heart Association Fellowship) University of Utah United States -
Research Interests
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Journals
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Conference Papers
Year Citation 2020 Sidhu, S. (2020). Role of group III/IV muscle afferents on central nervous system responses to exhaustive cycling exercise. In Proceedings of the 25th European Congress of Sports Science. Virtual online: ECSS. 2019 Otieno, L. A., Semmler, J., & Sidhu, S. (2019). Age-related changed in GABA-mediated inhibition with fatiguing single joint exercise.. In Proceedings of the ANS Sensorimotor Control Satellite Meeting. Adelaide. 2018 Sidhu, S. K. (2018). Preconditioning tDCS facilitates effects of subsequent tDCS applied during cycling exercise on corticospinal excitability and working memory in young adults. In Proceedings of the European College of Sports Science. Dublin. 2017 Sidhu, S., Weavil, J., Thurston, T., Wang, E., Rosenberger, D., Jessop, J., . . . Amann, M. (2017). Fatigue modulates the effect of group III/IV muscle afferents On Gabab mediated inhibition and corticospinal excitability. In Medicine and Science in Sports and Exercise Vol. 49 (pp. 695). Denver, Colorado: Lippincott Williams & Wilkins Ltd.. 2017 Lauber, B., Lichtwark, G., Sidhu, S. K., & Gollhofer, A. (2017). Effect of cadence on intracortical inhibition and facilitation during submaximal cycling. In European College of Sports Science. Ruhr University Bochum. 2017 Sidhu, S. K. (2017). Increasing motor cortex plasticity with spaced paired associative stimulation at different intervals in older adults. In Australasian Cognitive Neuroscience Conference. Adelaide. 2016 Mangum, T. S., Hureau, T. J., Weavil, J. C., Sidhu, S. K., Thurston, T. S., Nelson, A. D., . . . Amann, M. (2016). Ascorbate Attenuates the Development of Fatigue During Exercise in Patients with Chronic Obstructive Pulmonary Disease: 990 Board #306 June 1, 2: 00 PM - 3: 30 PM.. In Medicine and science in sports and exercise Vol. 48 (pp. 284). United States: Ovid Technologies (Wolters Kluwer Health).
2016 Hoeppli, M. E., Thurston, T. S., Sidhu, S. K., Mangum, T. S., Weavil, J. C., Hureau, T. J., . . . Schweinhardt, P. (2016). Differences in psychophysical responses to muscle stimulation in young and old healthy adults.. In The journal of pain : official journal of the American Pain Society Vol. 17 (pp. S63). United States: Elsevier BV.
2016 Weavil, J. C., Sidhu, S. K., Mangum, T. S., Thurston, T. S., Garten, R. S., Richardson, R. S., & Amann, M. (2016). Impact of Aging on Fatigue and Corticomotoneuronal Excitability during Small Muscle Mass Exercise. In FASEB JOURNAL Vol. 30 (pp. 2 pages). San Diego, CA: FEDERATION AMER SOC EXP BIOL. 2016 Mangum, T. S., Hureau, T. J., Weavil, J. C., Sidhu, S. K., Thurston, T. S., Nelson, A. D., . . . Amann, M. (2016). Ascorbate Attenuates the Development of Fatigue During Exercise in Patients with Chronic Obstructive Pulmonary Disease. In MEDICINE AND SCIENCE IN SPORTS AND EXERCISE Vol. 48 (pp. 284). Denver, CO: LIPPINCOTT WILLIAMS & WILKINS.
2015 Sidhu, S. K., Weavil, J. C., Mangum, T. S., Rossman, M. J., Jessop, J. E., Richardson, R. S., . . . Amann, M. (2015). Group III IV mediated muscle reflexes restrain vascular conductance during exercise in patients with hypertension. In Medicine and Science in Sports and Exercise. San Diego, USA: American College of Sports Medicine (ACSM). 2015 Blain, G. M., Mangum, T. S., Sidhu, S. K., Weavil, J. C., Richardson, R. S., Hureau, T. J., . . . Amann, M. (2015). Group III/IV muscle afferents restrict intramuscular metabolic perturbation in exercising humans. In Medicine and Science in Sports and Exercise. San Diego USA: American College of Sports Medicine (ACSM). 2015 Mangum, T. S., Sidhu, S. K., Weavil, J. C., Hureau, T. J., Richardson, R. S., & Amann, M. (2015). The development of peripheral and central fatigue during self- paced endurance exercise.. In Medicine and Science in Sports and Exercise. San Diego: American College of Sports Medicine (ACSM). 2015 Weavil, J. C., Sidhu, S. K., Venturelli, M., Rossman, M. J., Jessop, J. E., Richardson, R. S., . . . Amann, M. (2015). Muscle Reflex Effects on the Autonomic Hemodynamic Response to Passive Leg Movement in an Aged Population. In The FASEB Journal. San Diego, USA: Federation of American Society of Experimental Biology (FASEB). 2014 Sidhu, S. K., Weavil, J. C., Venturelli, M., Rossman, M. J., Gmelch, B. S., Bledsoe, A. D., . . . Amann, M. (2014). Aging alters muscle reflex control of autonomic cardiovascular responses to rhythmic contractions in humans. In FASEB. San Diego, USA. 2014 Sidhu, S. K. (2014). Spinal µ-opioid receptor sensitive locomotor muscle afferents decrease responsiveness of motor cortical cells and diminish cortical voluntary activation.. In J. C. Weavil, T. S. Mangum, D. E. Morgan, J. E. Jessop, R. S. Richardson, & M. Amann (Eds.), The FASEB Journal. San Diego, USA: Federation of American Society of Experimental Biology (FASEB). 2014 Weavil, J. C., Sidhu, S. K., Mangum, T. S., Rossman, M. J., Garten, R. S., Richardson, R. S., & Amann, M. (2014). Influence of locomotor muscle fatigue on modulating the responsiveness of the corticospinal pathway.. In Medicine and Science in Sports and Exercise. Florida, USA: American College of Sports Medicine (ACSM). 2014 Weavil, J. C., Sidhu, S. K., Mangum, T. S., Rossman, M. J., Garten, R. S., Richardson, R. S., & Amann, M. (2014). Influence Of Peripheral Fatigue And Descending Drive On The Responsiveness Of The Corticospinal Pathway During Cycling Exercise. In MEDICINE AND SCIENCE IN SPORTS AND EXERCISE Vol. 46 (pp. 858). Atlanta, GA: LIPPINCOTT WILLIAMS & WILKINS.
2013 Sidhu, S. K., Weavil, J. C., Venturelli, M., Richardson, R. S., Rossman, M. J., Garten, R. S., & Amann, M. (2013). Cortical voluntary activation and responsiveness of corticospinal tract to a remote muscle during cycling exercise sustained to task failure. In Proceedings of the 43rd Annual Society for Neuroscience Meeting. San Diego, USA. 2013 Marinovic, W., Tresilian, J., de Rugy, A., Sidhu, S. K., & Riek, S. (2013). The effects of loud auditory stimuli on corticospinal excitability during movement preparation. In Society for Neuroscience. San Diego, USA. 2013 Marinovic, W., Tresilian, J., de Rugy, A., Sidhu, S. K., & Riek, S. (2013). Corticospinal excitability and the early release of prepared responses by sound. In Proceedings of the Motor Control and Human Skill Conference. Melbourne, Australia. 2012 Sidhu, S. K., Lauber, B., Cresswell, A. G., & Carroll, T. J. (2012). Increased Intracortical Inhibition during 30 mins of sustained cycling exercise. In Proceedings of the "XIX Congress of the International Society of Electrophysiology and Kinesiology. Brisbane, Australia. 2011 Sidhu, S. K., Cresswell, A. G., & Carroll, T. J. (2011). Excitability of motor cortical neurons decreases during fatiguing cycling exercise. In Proceedings of "The future of Fatigue- Defining the Problem" Symposium.. Charles Stuart University, Bathurst, Australia. 2011 Sidhu, S. K., Cresswell, A. G., & Carroll, T. J. (2011). Modulation of corticospinal tract excitability in the knee extensor and flexor muscles during bicycling. In Proceedings of the Australian Society of Medical Research Conference. Princess Alexandra Hospital, Brisbane, Australia. 2010 Sidhu, S. K., Cresswell, A. G., & Carroll, T. J. (2010). Modulation of corticospinal tract excitability in the knee extensor and flexor muscles during bicycling. In Proceedings of the 40th Annual Society for Neuroscience Meeting. San Diego, USA. 2009 Cresswell, A. G., Hoffman, B. W., Sidhu, S. K., Oya, T., & Carroll, T. J. (2009). Central Fatigue and Changes in Corticospinal Responsiveness Induced by Submaximal Lower Limb Exercise. In ANS Sensorimotor Control Satellite Meeting: “The Jaw and More”. ANU, Canberra, Australia. 2008 Sidhu, S. K., Bentley, D. J., & Carroll, T. J. (2008). Long Lasting Impairments in the Capacity of the Human Motor Cortex to Voluntarily Activate Knee Extensor Muscles Following Cycling Exercise. In Proceedings of the 26th International Australasian Winter Conference on Brain Research, Volume 26, Abstract 10.5. Queenstown, New Zealand. -
Conference Items
Year Citation 2017 Sidhu, S. K., Weavil, J. C., Thurston, T. S., Wang, E., Rosenberger, D. S., Jessop, J. E., . . . Amann, M. (2017). Fatigue Modulates The Effect Of Group III/IV Muscle Afferents On GABAB-Mediated Inhibition And Corticospinal Excitability. Poster session presented at the meeting of MEDICINE AND SCIENCE IN SPORTS AND EXERCISE. Denver, CO: LIPPINCOTT WILLIAMS & WILKINS.
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Theses
Year Citation 2012 Sidhu, S. K. (2012). Effects of sustained cycling exercise on corticospinal responsiveness. (The University of Queensland, Australia).
My research has been funded by the following schemes and/or funding bodies:
- The Hospital Research Foundation (2024-2026)
- MS Research Australia (2020-21)
- The University of Adelaide Women’s Research Excellence Award, The University of Adelaide, Australia (2019)
- Faculty of Health and Medical Sciences Research Infrastructure Funding Awards, The University of Adelaide, Australia (2017-2023)
- Faculty of Health and Medical Sciences Research Committee Early Career Researcher Mentored Project Development Program, The University of Adelaide, Australia (2017-18)
- Faculty of Health and Medical Sciences Research Travel Awards, The University of Adelaide, Australia (2017-2023)
- German Research Foundation (DFG) International Collaboration Grant (2017)
- Adelaide Medical School Equipment Grant, The University of Adelaide, Australia (2016)
- Priority Partner Grant, The University of Adelaide, Australia (2015)
- School of Medical Sciences Kick-Start Funding, The University of Adelaide, Australia (2015)
- American Heart Association Fellowship Grant, American Heart Association, USA (2014-2015)
- The University of Utah Postdoctoral Travel Grant (2013)
- Technische Universität München, Germany. Research Opportunity Week Grant (2013)
- Sports Medicine Australia Research Foundation Grant, Sports Medicine Australia, Australia (2011)
- School of Human Movement Studies, University of Queensland Postgraduate Travel Grant (2008)
- The University of Queensland Postgraduate Research Scholarship, The University of Queensland, Australia (2008-2012)
- Endeavour International Postgraduate Research Scholarship, Department of Education, Australia (2008-2012)
Teaching Interests: Neurophysiology, Human Motor Control and Learning, Exercise Science, Integrative Human Physiology
Bachelor of Health and Medical Sciences Program Honours Coordinator (Biomedicine Cluster)
Course Coordination & Teaching:
- Human Motor Behaviour and Learning (Semester 2)
- Research Placement Part 1 (Semester 1 & 2)
- Research Placement Part 2 (Semester 1 & 2)
- Research Integrated Learning (Semester 1 & 2)
Teaching contribution in other courses:
- Exercise, Nutrition and Metabolism (HLTH SC 3100; Semester 1)
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 Principal Supervisor The interaction between diet, physical activity and neuroplasticity in multiple sclerosis Doctor of Philosophy Doctorate Full Time Miss Madison Boda -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2018 - 2022 Co-Supervisor Impact of Fatiguing Exercise on Corticospinal Excitability and Motor Performance in Young and Older Adults Doctor of Philosophy Doctorate Full Time Miss Lavender Achieng Otieno 2018 - 2022 Co-Supervisor Motor Cortex Plasticity and Skill Acquisition in Endurance-Trained Athletes Doctor of Philosophy Doctorate Full Time Mr Brodie Hand -
Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2020 - ongoing External Supervisor Neural contributions to motor impairment in people with painful knee osteoarthritis University of South Australia MPhil Master Part Time Johanna Paddick 2019 - 2020 External Supervisor The interaction between neuromodulation and fatigue in Multiple Sclerosis The University of Verona, Italy MSc Master Full Time Chiara Barbi
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Committee Memberships
Date Role Committee Institution Country 2018 - ongoing Member Faculty of Health and Medical Sciences - Health Safety and Wellbeing Committee The University of Adelaide Australia 2017 - ongoing Member Big Science Adelaide (Sub Committee of NSW Committee) - Australia 2017 - ongoing Member Low-Risk Human Research Ethics Committee The University of Adelaide Australia 2017 - ongoing Member National Science Week Committee (South Australia) - Australia 2013 - 2015 Board Member The University of Utah Postdoctoral Association The University of Utah United States 2010 - 2011 Chair School of Human Movement Studies Postgraduate Students Executive Committee The University of Queensland Australia -
Memberships
Date Role Membership Country 2017 - ongoing Member Australasian Cognitive Neuroscience Society Australia 2017 - ongoing Member Exercise and Sports Science Australia Australia 2015 - ongoing Member American College of Sports Medicine United States 2013 - ongoing Member Society for Neuroscience United States 2013 - ongoing Member American Heart Association United States -
Review, Assessment, Editorial and Advice
Date Title Type Institution Country 2020 - ongoing Review Editor for Frontiers in Physiology (Exercise Physiology) Editorial Frontiers - 2019 - ongoing Brain Sciences - Special Issue Guest Editor Editorial MDPI Switzerland
Connect With Me
External Profiles