Higher Degree by Research Candidate
School of Biomedicine
Faculty of Health and Medical Sciences
Endometrial cancer is the most common gynaecological malignancy and sixth most common cancer in women. The disease has distinctive symptoms of post menopausal bleeding and can be diagnosed early. Despite early diagnosis and good prognosis, the treatment options are quite limited. Standard treatment is bilateral removal of uterus and ovaries while advanced cases are managed by chemotherapy or hormonal therapy. Each treatment modality is associated with compromised fertility and high rates of recurrences. Finding new treatment options is a need in research. One of the therapeutic target is aquaporins which are transmembrane transport channels, responsible for transport of solutes across the membrane. There are 13 classes of mammalian aquaporins (aqp0-12) distributed all over the body. They mediate physiological functions and are found to be involved in cancer progression and metastasis. Over expression of aquaporins had been found in colorectal cancer, breast cancer, glioblastoma, prostate cancer and ovarian cancer. pharmacological blockade or knock down of aquaporins has been found promising in various cancers. The expression of aqp-2, -3, -5 have been found in endometrial cancer and knock down of aqp-2 and -5 has inhibited invasion of endometrial cancer cells. However, gap exists as to role of other aquaporins in endometrial cancer. My research deals with analysing expression of aquaporins in endometrial cancer cells and looking for new therapeutic strategies for endometrial cancer, that makes the basis of drug discovery for endometrial cancer.
Language Competency English Can read, write, speak, understand spoken and peer review Urdu Can read, write, speak, understand spoken and peer review
Date Institution name Country Title 2020 Adelaide medical school, univeristy of adelaide Australia PhD 2017 - 2019 Adelaide medical school, univeristy of adelaide Australia honours of health sciences 2003 - 2009 university of health sciences Pakistan MBBS
Date Title Institution name Country 2009 MBBS University of health sciences Pakistan
Year Citation 2023 Khan, S., Lokman, N. A., Oehler, M. K., Ricciardelli, C., & Yool, A. J. (2023). Reducing the Invasiveness of Low- and High-Grade Endometrial Cancers in Both Primary Human Cancer Biopsies and Cell Lines by the Inhibition of Aquaporin-1 Channels. Cancers, 15(18), 1-27.
2023 Varricchio, A., Khan, S., Price, Z. K., Davis, R. A., Ramesh, S. A., & Yool, A. J. (2023). Pharmacological Inhibition of Membrane Signaling Mechanisms Reduces the Invasiveness of U87-MG and U251-MG Glioblastoma Cells In Vitro. Cancers, 15(4), 1027.
DOI Scopus4 WoS4 Europe PMC3
2022 Khan, S., Varricchio, A., Ricciardelli, C., & Yool, A. J. (2022). Invasiveness of endometrial cancer cell lines is potentiated by estradiol and blocked by a traditional medicine Guizhi Fuling at clinically relevant doses.. Frontiers in Oncology, 12, 15 pages.
DOI Scopus2 WoS2 Europe PMC2
2021 Khan, S., Ricciardelli, C., & Yool, A. J. (2021). Targeting aquaporins in novel therapies for male and female breast and reproductive cancers. Cells, 10(2), 1-18.
DOI Scopus15 WoS13 Europe PMC10
2018 Khan, S., Wardill, H. R., & Bowen, J. M. (2018). Role of toll-like receptor 4 (TLR4)-mediated interleukin-6 (IL-6) production in chemotherapy-induced mucositis. Cancer Chemotherapy and Pharmacology, 82(1), 31-37.
DOI Scopus16 WoS15 Europe PMC7
Year Citation 2021 Khan, S., Ricciardelli, C., & Yool, A. (2021). EPV114/# 325 Expression of aquaporins in human endometrial cancer: identification and regulation by ovarian hormones in carcinogenesis of endometrial cancer. Poster session presented at the meeting of International gynaecological cancer society. 2021 Khan, S., Ricciardelli, C., & Yool, A. (2021). Fuling inhibits invasion in endometrial cancer cells.. Poster session presented at the meeting of EMBL Australia. 2021 Khan, S., Ricciardelli, C., & Yool, A. (2021). Fuling inhibits invasion in endometrial cancer cells. Poster session presented at the meeting of Australian Metastasis Research Society (OzMRS). 2021 Khan, S., Ricciardelli, C., & Yool, A. (2021). Fuling inhibits invasion in endometrial cancer cells. Poster session presented at the meeting of Australian Physiological society (AuPS) (oral presentation). 2021 Khan, S., Ricciardelli, C., & Yool, A. (2021). Identification of Aquaporins in human endometrial cancer and regulation by ovarian hormones in carcinogenesis.. Poster session presented at the meeting of The Australian Society for Medical Research National Scientific Conference, Adelaide, Australia..
Facilitator to coordinator create communicate connect (CCC); 2020 semester 1
Tutoring BfNP ; 2021 semester 1
Anatomy demonstrator MBBS I, II, III ; 2021 semester 1,2
Anatomy demonstrator MBBS II ; 2022 semester 1
Scenario based learning MBBS I; 2022 Semester 1,2
Demonstrator physiology IIA, IIB practicals; 2021
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