
Sharon Byers
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
I am Head of the Matrix Biology Unit, Genetics and Molecular Pathology, SA Pathology (WCH site). My overall area of research interest is the role of complex carbohydrates (glycosaminoglycans) in growth, development and disease. A major focus is the development and testing of novel therapies for the treatment of skeletal disease in the mucopolysaccharidoses, a group of genetic disorders arising from impaired glycosaminoglycan turnover.
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Appointments
Date Position Institution name 2007 Affiliate Senior Lecturer University of Adelaide, Adelaide 1999 Head, Matrix Biology Unit SA Pathology (WCH site) 1995 Affiliate Senior Lecturer University of Adelaide, Adelaide 1993 - 1999 Grant Funded Scientist Women's and Children's Hospital, Adelaide 1989 - 1992 Senior Research Officer Women's and Children's Hospital, Adelaide 1987 - 1988 Assistant Professor West Virginia University, Morgantown -
Education
Date Institution name Country Title 1980 - 1984 Monash University, Melbourne Australia PhD 1979 - 1979 Monash University, Melbourne Australia BSc (hons) 1976 - 1978 Monash University, Melbourne Australia BSc -
Postgraduate Training
Date Title Institution Country 1983 - 1987 Postdoctoral Fellow Rush University Medical Center, Chicago United States -
Research Interests
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Journals
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Book Chapters
Year Citation 2005 Byers, S., Lee, J., Fietz, M., & Thomas, B. (2005). Characterisation of human hyaluronidase 1.. In E. A. Balazs, & V. C. Hascall (Eds.), Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications (Vol. 1, 1 ed., pp. 225-228). 2005 Adams, J. R. J., & Byers, S. (2005). Hyaluronan metabolism in the MG63 osteoblast cell line.. In E. A. Balazs (Ed.), Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications (pp. 459-463). 1995 Byard, R. W., Fazzalari, N. L., Byers, S., Moore, A., Wisdon, C., Makrides, M., . . . Gibson, R. A. (1995). Studies of bone growth and cerebral lipid levels in SIDS.. In T. O. Rognum (Ed.), Sudden Infant Death Syndrome. New Trends in the Nineties (pp. 242-244). -
Conference Papers
Year Citation 2017 Byers, S., Jiang, Z., Reichstein, C., & Derrick-Roberts, A. L. K. (2017). Cell cycle progression is disrupted in murine MPS VII growth plate chondrocytes. In MOLECULAR GENETICS AND METABOLISM Vol. 120 (pp. S33). San Diego, CA: ACADEMIC PRESS INC ELSEVIER SCIENCE.
2016 Jiang, Z., Rossouw, C., Reichstein, C., Macsai, C. E., Jackson, M. R., Derrick-Roberts, A. L. K., & Byers, S. (2016). Reduced chondrocyte proliferation and hypertrophy contribute to delayed endochondral bone formation in murine mucopolysaccharidosis VII. In MOLECULAR GENETICS AND METABOLISM Vol. 117 (pp. S62-S63). San Diego, CA: ACADEMIC PRESS INC ELSEVIER SCIENCE.
2015 Byers, S., Pout-Pitt, N., Linard, H., Ainslie, L. K., & Roberts, S. A. D. (2015). MPS GAG modulate mesenchymal stem cell differentiation. In MOLECULAR GENETICS AND METABOLISM Vol. 114 (pp. S27-S28). Orlando, FL: ACADEMIC PRESS INC ELSEVIER SCIENCE.
2015 Jackson, M., Roberts, A. D., Gronthos, S., & Byers, S. (2015). IDURONIDASE TRANSDUCED MSCS IMPROVE THE BEHAVIOURAL DEFICITS IN MUCOPOLYSACCHARIDOSIS I MICE WITH LIMITED BIOCHEMICAL CORRECTIONS. In JOURNAL OF GENE MEDICINE Vol. 17 (pp. 197-198). Univ Melbourne, Univ Coll, Parkville, AUSTRALIA: WILEY-BLACKWELL. 2015 Jackson, M., Robertsa, A., Gronthos, S., & Byers, S. (2015). α-l-Iduronidase transduced mesenchymal stem cells improve the behavioral deficits in mucopolysaccharidosis type I mice. In Abstracts Molecular Genetics and Metabolism Vol. 114 (pp. S58). Orlando, FL: Elsevier.
2015 Byers, S., Pyragius, C., Panir, K., Anson, D., & Roberts, A. D. (2015). LENTIVIRAL-MEDIATED GENE THERAPY IN THE MUCOPOLYSACCHARIDOSIS TYPE VII MOUSE. In JOURNAL OF GENE MEDICINE Vol. 17 (pp. 198). Univ Melbourne, Univ Coll, Parkville, AUSTRALIA: WILEY-BLACKWELL. 2015 McIntyre, C., Byers, S., & Anson, D. (2015). REPORTER AND THERAPEUTIC GENE TRANSFER TO THE BRAINS OF NORMAL AND MUCOPOLYSACCHARIDOSIS IIIA MICE, RESPECTIVELY, FOLLOWING INTRACEREBROVENTRICULAR DELIVERY OF LENTIVIRUS. In JOURNAL OF GENE MEDICINE Vol. 17 (pp. 196). Univ Melbourne, Univ Coll, Parkville, AUSTRALIA: WILEY-BLACKWELL. 2009 Byers, S., Fazzalari, N. L., Hopwood, J. J., & Hein, L. K. (2009). Progression of skeletal disease in MPS disorders. In BONE Vol. 44 (pp. S122). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC.
2007 Smith, L. J., Byers, S., Costi, J. J., & Fazzalari, N. L. (2007). The roles of elastic fibres and glycosaminoglycans in the radial tensile mechanics of the human lumbar anulus fibrosus. In Proceedings of the ASME Summer Bioengineering Conference 2007, SBC 2007 (pp. 875-876). Keystone, CO: AMER SOC MECHANICAL ENGINEERS.
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Conference Items
Year Citation 2018 Byers, S., Rout-Pitt, N., Linard, H., Vaidyanathan, S., & Derrick-Roberts, A. L. (2018). MESENCHYMAL STEM CELL DIFFERENTIATION IS MODULATED BY COMPLEX SUGARS IN MPS DISEASE. Poster session presented at the meeting of JOURNAL OF GENE MEDICINE. Univ Technol Sydney, Sydney, AUSTRALIA: WILEY.
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Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2015 - 2019 Principal Supervisor The Neurogenic Potential of Stem Cells is Altered in Mucopolysaccharidosis Type IIIA Doctor of Philosophy Doctorate Full Time Rebecca Jayne Lehmann 2014 - 2018 Principal Supervisor Mechanisms of Growth Failure in Mucopolysaccharidosis VII Mice Doctor of Philosophy Doctorate Full Time Miss Zhirui Jiang 2011 - 2015 Principal Supervisor The Effects of Undergraded Glycosaminoglycans from Mucopolysaccharidoses on Osteoblast Differentiation and Mineralisation In Vitro Doctor of Philosophy Doctorate Full Time Dr Nathan Bradley Rout-Pitt 2010 - 2015 Principal Supervisor ALPHA-L-IDURONIDASE TRANSDUCED MESENCHYMAL STEM CELLS AS A THERAPY FOR THE TREATMENT OF CNS DEGENERATION IN MUCOPOLYSACCHARIDOSIS TYPE I MICE Doctor of Philosophy Doctorate Full Time Dr Matilda Jackson 2008 - 2014 Principal Supervisor Development of neuropathology in murine MPS IIIA and MPS VII and the effect of N-butyldeoxynojirimycin treatment on MPS IIIA mice Doctor of Philosophy Doctorate Full Time Miss Xenia Kaidonis 2006 - 2014 Co-Supervisor Lentiviral-mediated Gene Therapy for Mucopolysaccharidosis Type IIIA Doctor of Philosophy Doctorate Full Time Dr Chantelle McIntyre 2005 - 2008 Co-Supervisor Structure and Function of the Elastic Fibre Network of the Human Lumbar Anulus Fibrosus Doctor of Philosophy Doctorate Full Time Mr Lachlan Smith 2003 - 2007 Principal Supervisor Substrate Deprivation as a Novel Therapy for the Mucopolysaccharidoses Doctor of Philosophy Doctorate Full Time Miss Ainslie Derrick Roberts 2002 - 2005 Co-Supervisor Formation of Ovarian Follicular Fluid Doctor of Philosophy Doctorate Part Time Ms Hannah Clarke 2001 - 2007 Principal Supervisor Characterisation of Recombinant Hyaluronidase-1 and -3, and of Hyaluronan turnover in Mineralising Osteoblasts Doctor of Philosophy Doctorate Full Time Mr Julian Adams 1999 - 2004 Co-Supervisor The Effect of Recombinant Human Osteogenic Protein-1 on Growth Plate Repair in a Sheep Model Doctor of Philosophy Doctorate Full Time Ms Belinda Thomas -
Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2018 - ongoing Principal Supervisor An in vitro model to study growth plate function. The University of Adelaide — Honours — Daniel Deverson 2017 - 2017 Principal Supervisor Does GH or iGF1 promote bone growth in MPS VII mice ? The University of Adelaide — Honours — Niemal Usmani 2016 - 2016 Principal Supervisor Development of human in vitro models of MPS IVA skeletal pathology. The University of Adelaide — Honours — Srimayee Viadanathan 1998 - 2003 Principal Supervisor Characterisation of osteoblast function in a feline model of MPS VI. The University of Adelaide — Higher Doctorate — Krystyne Zarrinkalam
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Committee Memberships
Date Role Committee Institution Country 2016 - ongoing Member IBC Womens and Children's Health Network Australia 2013 - ongoing Member SPDF funding committee SA Pathology Australia 2010 - ongoing Member Radiation Safety Committee SA Pathology Australia
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