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Sharon Byers

Sharon Byers
Adelaide Medical School
Faculty of Health and Medical Sciences

I am Head of the Matrix Biology Unit, Genetics and Molecular Pathology, SA Pathology (WCH site). My overall area of research interest is the role of complex carbohydrates (glycosaminoglycans) in growth, development and disease. A major focus is the development and testing of novel therapies for the treatment of skeletal disease in the mucopolysaccharidoses, a group of genetic disorders arising from impaired glycosaminoglycan turnover.

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Sharon Byers

I am Head of the Matrix Biology Unit, Genetics and Molecular Pathology, SA Pathology (WCH site). My overall area of research interest is the role of complex carbohydrates (glycosaminoglycans) in growth, development and disease. A major focus is the development and testing of novel therapies for the treatment of skeletal disease in the mucopolysaccharidoses, a group of genetic disorders arising from impaired glycosaminoglycan turnover.

Eligible to supervise Masters and PhD — email supervisor to discuss availability.

Appointments

Date Position Institution name
2007 Affiliate Senior Lecturer University of Adelaide, Adelaide
1999 Head, Matrix Biology Unit SA Pathology (WCH site)
1995 Affiliate Senior Lecturer University of Adelaide, Adelaide
1993 - 1999 Grant Funded Scientist Women's and Children's Hospital, Adelaide
1989 - 1992 Senior Research Officer Women's and Children's Hospital, Adelaide
1987 - 1988 Assistant Professor West Virginia University, Morgantown

Education

Date Institution name Country Title
1980 - 1984 Monash University, Melbourne Australia PhD
1979 - 1979 Monash University, Melbourne Australia BSc (hons)
1976 - 1978 Monash University, Melbourne Australia BSc

Postgraduate Training

Date Title Institution Country
1983 - 1987 Postdoctoral Fellow Rush University Medical Center, Chicago United States

Research Interests

Journals

Year Citation
2018 Jiang, Z., Derrick-Roberts, A., Jackson, M., Rossouw, C., Pyragius, C., Xian, C., . . . Byers, S. (2018). Delayed development of ossification centers in the tibia of prenatal and early postnatal MPS VII mice. Molecular Genetics and Metabolism, 124(2), 135-142.
DOI
2017 Derrick Roberts, A., Jackson, M., Pyragius, C., & Byers, S. (2017). Substrate deprivation therapy to reduce glycosaminoglycan synthesis improves aspects of neurological and skeletal pathology in MPS I mice. Diseases, 5(1), 5-1-5-16.
DOI
2016 Kaidonis, X., Byers, S., Ranieri, E., Sharp, P., Fletcher, J., & Derrick-Roberts, A. (2016). N-butyldeoxynojirimycin treatment restores the innate fear response and improves learning in mucopolysaccharidosis IIIA mice. Molecular Genetics and Metabolism, 118(2), 100-110.
DOI Europe PMC1
2016 Derrick-Roberts, A., Panir, K., Pyragius, C., Zarrinkalam, K., Atkins, G., & Byers, S. (2016). Reversal of established bone pathology in MPS VII mice following lentiviral-mediated gene therapy. Molecular Genetics and Metabolism, 119(3), 249-257.
DOI Scopus2 WoS1 Europe PMC1
2015 Jackson, M., Derrick Roberts, A., Martin, E., Rout-Pitt, N., Gronthos, S., & Byers, S. (2015). Mucopolysaccharidosis enzyme production by bone marrow and dental pulp derived human mesenchymal stem cells. Molecular Genetics and Metabolism, 114(4), 584-593.
DOI Scopus3 WoS3 Europe PMC1
2014 Mcintyre, C., Derrick-Roberts, A., Byers, S., & Anson, D. (2014). Correction of murine mucopolysaccharidosis type IIIA central nervous system pathology by intracerebroventricular lentiviral-mediated gene delivery. Journal of Gene Medicine, 16(11-12), 374-387.
DOI Scopus7 WoS5 Europe PMC3
2014 Derrick-Roberts, A., Pyragius, C., Kaidonis, X., Jackson, M., Anson, D., & Byers, S. (2014). Lentiviral-mediated gene therapy results in sustained expression of β-Glucuronidase for up to 12 Months in the Gus mps/mps and up to 18 Months in the Gus tm(L175F)Sly mouse models of mucopolysaccharidosis type VII. Human Gene Therapy, 25(9), 798-810.
DOI Scopus8 WoS7 Europe PMC3
2012 Derrick Roberts, A., Marais, W., & Byers, S. (2012). Rhodamine B and 2-acetamido-1,3,6-tri-O-acetyl-4-deoxy-4-fluoro-D-glucopyranose(F-GlcNAc) inhibit chondroitin/dermatan and keratan sulphate synthesis by different mechanisms in bovine chondrocytes. Molecular Genetics and Metabolism, 106(2), 214-220.
DOI Scopus4 WoS3 Europe PMC1
2012 Pyragius, C., Derrick Roberts, A., Ding, X., Zarrinkalam, K., McIntyre, C., Anderson, P., . . . Byers, S. (2012). Skeletal response to lentiviral mediated gene therapy in a mouse model of MPS VII. Molecular Genetics and Metabolism, 106(2), 202-213.
DOI Scopus15 WoS14 Europe PMC11
2011 Anson, D., McIntyre, C., & Byers, S. (2011). Therapies for neurological disease in the mucopolysaccharidoses. Current Gene Therapy, 11(2), 132-143.
DOI Scopus9 WoS9 Europe PMC5
2010 McIntyre, C., Byers, S., & Anson, D. (2010). Correction of mucopolysaccharidosis type IIIA somatic and central nervous system pathology by lentiviral-mediated gene transfer. Journal of Gene Medicine, 12(9), 717-728.
DOI Scopus27 WoS24 Europe PMC13
2010 Derrick Roberts, A., Fletcher, J., Moore, L., & Byers, S. (2010). Trans-generational exposure to low levels of rhodamine B does not adversely affect litter size or liver function in murine mucopolysaccharidosis type IIIA. Molecular Genetics and Metabolism, 101(2-3), 208-213.
DOI Scopus12 WoS12 Europe PMC8
2010 Kaidonis, X., Liaw, W., Derrick Roberts, A., Ly, M., Anson, D., & Byers, S. (2010). Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses. European Journal of Human Genetics, 18(2), 194-199.
DOI Scopus25 WoS21 Europe PMC15
2010 Auclair, D., Ketteridge, D., Oates, S., Hopwood, J. J., & Byers, S. (2010). An overview of intra-articular therapy for mucopolysaccharidosis VI.. Journal of pediatric rehabilitation medicine, 3(1), 3-6.
DOI Europe PMC2
2009 Byers, S., Rothe, M., Lalic, J., Koldej, R., & Anson, D. (2009). Lentiviral-mediated correction of MPS VI cells and gene transfer to joint tissues. Molecular Genetics and Metabolism, 97(2), 102-108.
DOI Scopus16 WoS14 Europe PMC8
2009 Derrick Roberts, A., Howarth, G., Liaw, W., Moretta, S., Kritas, S., Lymn, K., . . . Byers, S. (2009). Gastrointestinal Pathology in a Mouse Model of Mucopolysaccharidosis Type IIIA. Journal of Cellular Physiology, 219(2), 259-264.
DOI Scopus6 WoS5 Europe PMC3
2008 Atmuri, V., Martin, D., Hemming, R., Gutsol, A., Byers, S., Sahebjam, S., . . . Triggs-Raine, B. (2008). Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of hyaluronan accumulation. Matrix Biology, 27(8), 653-660.
DOI Scopus38 WoS32 Europe PMC31
2008 Sakko, A., Butler, M., Byers, S., Reinboth, B., Stahl, C., Kench, J., . . . Ricciardelli, C. (2008). Immunohistochemical level of unsulfated chondroitin disaccharides in the cancer stroma is an independent predictor of prostate cancer relapse. Cancer Epidemiology Biomarkers & Prevention, 17(9), 2488-2497.
DOI Scopus19 WoS18 Europe PMC6
2008 Martin, D., Atmuri, V., Hemming, R., Farley, J., Mort, J., Byers, S., . . . Triggs-Raine, B. (2008). A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis. Human Molecular Genetics, 17(13), 1904-1915.
DOI Scopus45 WoS42 Europe PMC35
2008 McIntyre, C., Derrick Roberts, A., Ranieri, E., Clements, P., Byers, S., & Anson, D. (2008). Lentiviral-mediated gene therapy for murine mucopolysaccharidosis type IIIA. Molecular Genetics and Metabolism, 93(4), 411-418.
DOI Scopus24 WoS25 Europe PMC14
2008 Bastow, E., Byers, S., Golub, S., Clarkin, C., Pitsillides, A., & Fosang, A. (2008). Hyaluronan synthesis and degradation in cartilage and bone. Cellular and Molecular Life Sciences, 65(3), 395-413.
DOI Scopus93 WoS86 Europe PMC58
2008 Smith, L., Byers, S., Costi, J., & Fazzalari, N. (2008). Elastic fibers enhance the mechanical integrity of the human lumbar anulus fibrosus in the radial direction. Annals of Biomedical Engineering, 36(2), 214-223.
DOI Scopus40 WoS40 Europe PMC30
2007 Anson, D., McIntyre, C., Thomas, B., Koldej, R., Ranieri, E., Derrick Roberts, A., . . . Byers, S. (2007). Lentiviral-mediated gene correction of mucopolysaccharidosis type IIIA. Genetic Vaccines and Therapy, 5(6), WWW 1-WWW 8.
DOI Scopus16 Europe PMC17
2007 Derrick Roberts, A., Rees, M., Klebe, S., Fletcher, J., & Byers, S. (2007). Improvement in behaviour after substrate deprivation therapy with rhodamine B in a mouse model of NIPSIIIA. Molecular Genetics and Metabolism, 92(1-2), 115-121.
DOI Scopus47 Europe PMC32
2007 Auclair, D., Hopwood, J., Lemontt, J., Chen, L., & Byers, S. (2007). Long-term intra-articular administration of recombinant human N-acetylgalactosamine-4-sulfatase in feline mucopolysaccharidosis VI. Molecular Genetics and Metabolism, 91(4), 352-361.
DOI Scopus22 WoS17 Europe PMC11
2007 Ricciardelli, C., Russell, D., Ween, M., Mayne, K., Suwiwat, S., Byers, S., . . . Horsfall, D. (2007). Formation of hyaluronan- and versican-rich pericellular matrix by prostate cancer cells promotes cell motility. Journal of Biological Chemistry, 282(14), 10814-10825.
DOI Scopus95 WoS94 Europe PMC70
2006 Derrick Roberts, A., Thomas, B., Wilkinson, A., Fletcher, J., & Byers, S. (2006). Inhibition of glycosaminoglycan synthesis using rhodamine B in a mouse model of mucopolysaccharidosis type IIIA. Pediatric Research, 60(3), 309-314.
DOI Scopus58 Europe PMC36
2006 Clarke, H., Hope, S., Byers, S., & Rodgers, R. (2006). Formation of ovarian follicular fluid may be due to the osmotic potential of large glycosaminoglycans and proteoglycans. Reproduction, 132(1), 119-131.
DOI Scopus34 WoS34 Europe PMC23
2006 Auclair, D., Hein, L., Hopwood, J., & Byers, S. (2006). Intra-articular enzyme administration for joint disease in feline mucopolysaccharidosis VI: Enzyme dose and interval. Pediatric Research, 59(4 Part 1), 538-543.
DOI Scopus24 WoS22 Europe PMC10
2006 Adams, J., Sander, G., & Byers, S. (2006). Expression of hyaluronan synthases and hyaluronidases in the MG63 osteoblast cell line. Matrix Biology, 25(1), 40-46.
DOI Europe PMC5
2005 Thomas, B., Byers, S., Johnstone, E., & Foster, B. (2005). The effect of recombinant human osteogenic protein-1 on growth plate repair in a sheep model. Journal of Orthopaedic Research, 23(6), 1336-1344.
DOI
2005 Thomas, B., Byers, S., Johnstone, E., & Foster, B. (2005). The effect of recombinant human osteogenic protein-1 on growth plate repair in a sheep model.. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 23(6), 1336-1344.
DOI Europe PMC4
2004 Crawley, A., Ramsay, S., Byers, S., Hopwood, J., & Meikle, P. (2004). Monitoring dose response of enzyme replacement therapy in feline mucopolysaccharidosis type VI by tandem mass spectrometry. Pediatric Research, 55(4), 585-591.
DOI Scopus21 WoS17 Europe PMC9
2002 Johnstone, E., McArthur, M., Solly, P., Higginson, K., Byers, S., & Foster, B. (2002). The effect of osteogenic protein-1 in an in vivo physeal injury model. Clinical Orthopaedics and Related Research, (395), 234-240.
Europe PMC2
2000 Johnstone, E., Leane, P., Byers, S., Hopwood, J., & Foster, B. (2000). Metaphyseal factors promote calcium incorporation in physeal chondrocyte cultures. Journal of Orthopaedic Science, 5(6), 593-599.
DOI Europe PMC1
2000 Johnstone, E., Leane, P., Kolesik, P., Byers, S., & Foster, B. (2000). Spatial arrangement of physeal cartilage chondrocytes and the structure of the primary spongiosa. Journal of Orthopaedic Science, 5(3), 294-301.
DOI
2000 Byers, S., Crawley, A., Brumfield, L., Nuttall, J., & Hopwood, J. (2000). Enzyme replacement therapy in a feline model of MPS VI: Modification of enzyme structure and dose frequency. Pediatric Research, 47(6), 743-749.
DOI WoS27 Europe PMC15
2000 Byers, S., Moore, A., Byard, R., & Fazzalari, N. (2000). Quantative histomorphometric analysis of the human growth plate from birth to adolescence. Bone, 27(4), 495-501.
DOI Scopus58 WoS52 Europe PMC38
2000 McArthur, M., Irving-Rodgers, H., Byers, S., & Rodgers, R. (2000). Identification and immunolocalization of decorin, versican, perlecan, nidogen, and chondroitin sulfate proteoglycans in bovine small-antral ovarian follicles. Biology of Reproduction, 63(3), 913-924.
DOI Scopus53 WoS47 Europe PMC33
2000 Johnstone, E., Leane, P., Kolesik, P., Byers, S., & Foster, B. (2000). Spatial arrangement of physeal cartilage chondrocytes and the structure of the primary spongiosa.. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 5(3), 294-301.
DOI Europe PMC5
1999 Perkins, K., Byers, S., Yogalingam, G., Weber, B., & Hopwood, J. (1999). Expression and characterization of wild type and mutant recombinant human sulfamidase - Implications for Sanfilippo (mucopolysaccharidosis IIIA) syndrome. Journal of Biological Chemistry, 274(52), 37193-37199.
DOI WoS29 Europe PMC20
1999 Nuttall, J., Brumfield, L., Fazzalari, N., Hopwood, J., & Byers, S. (1999). Histomorphometric analysis of the tibial growth plate in a feline model of mucopolysaccharidosis type VI. Calcified Tissue International, 65(1), 47-52.
DOI WoS24 Europe PMC22
1998 Bunge, S., Clements, P., Byers, S., Kleijer, W., Brooks, D., & Hopwood, J. (1998). Genotype-phenotype correlations in mucopolysaccharidosis type I using enzyme kinetics, immunoquantification and in vitro turnover studies. Biochimica et Biophysica Acta, 1407(3), 249-256.
DOI WoS50 Europe PMC37
1998 Jones, M., Brumfield, L., King, B., Hopwood, J., & Byers, S. (1998). Recombinant caprine H-3-[N-acetylglucosamine-6-sulfatase] and human H-3-[N-acetylgalactosamine-4-sulfatase] - Plasma clearance, tissue distribution, and cellular uptake in the rat. JOURNAL OF MOLECULAR NEUROSCIENCE, 11(3), 223-232.
DOI WoS4 Europe PMC3
1998 Byard, R., Byers, S., Moore, A., Leppard, P., & Fazzalari, N. (1998). Morphometric assessment of bone and growth plate in sudden infant death syndrome. Journal of Sudden Infant Death Syndrome and Infant Mortality, 2(3), 151-160.
Scopus2
1998 Byers, S., Rozaklis, T., Brumfield, L., Ranieri, E., & Hopwood, J. (1998). Glycosaminoglycan accumulation and excretion in the mucopolysaccharidoses: Characterization and basis of a diagnostic test for MPS. Molecular Genetics and Metabolism, 65(4), 282-290.
DOI WoS47 Europe PMC39
1997 Fazzalari, N., Moore, A., Byers, S., & Byard, R. (1997). Quantitative analysis of trabecular morphogenesis in the human costochondral junction during the postnatal period in normal subjects. The Anatomical Record, 248(1), 1-12.
DOI
1997 Byers, S., Nuttall, J., Crawley, A., Hopwood, J., Smith, K., & Fazzalari, N. (1997). Effect of enzyme replacement therapy on bone formation in a feline model of mucopolysaccharidosis Type VI. Bone, 21(5), 425-431.
DOI WoS40 Europe PMC25
1997 Fazzalari, N., Moore, A., Byers, S., & Byard, R. (1997). Quantitative analysis of trabecular morphogenesis in the human costochondral junction during the postnatal period in normal subjects. The Anatomical Record, 248(1), 1-12.
DOI Scopus35 WoS32 Europe PMC25
1997 Brooks, D., King, B., Crawley, A., Byers, S., & Hopwood, J. (1997). Enzyme replacement therapy in Mucopolysaccharidosis VI: evidence for immune responses and altered efficacy of treatment in animal models. Biochimica et Biophysica Acta, 1361(2), 203-216.
DOI WoS32 Europe PMC17
1997 Byers, S., van Rooden, J., & Foster, B. (1997). Structural changes in the large proteoglycan, aggrecan, in different zones of the ovine growth plate. Calcified Tissue International, 60(1), 71-78.
DOI Europe PMC14
1997 Crawley, A., Niedzielski, K., Isaac, E., Davey, R., Byers, S., & Hopwood, J. (1997). Enzyme replacement therapy from birth in a feline model of mucopolysaccharidosis type VI. Journal of Clinical Investigation, 99(4), 651-662.
DOI WoS91 Europe PMC63
1996 Crawley, A., Brooks, D., Muller, V., Petersen, B., Isaac, E., Bielicki, J., . . . Hopwood, J. (1996). Enzyme replacement therapy in a feline model of Maroteaux-Lamy syndrome. Journal of Clinical Investigation, 97(8), 1864-1873.
DOI WoS110 Europe PMC70
1995 Byard, R., Fazzalari, N., Moore, A., & Byers, S. (1995). Morphometric analysis of the bone growth plate in sudden infant death syndrome. Pathology, 27, S6.
1995 Clarke, J., Byers, S., Moore, A., Fazzalari, N., & Hopwood, J. (1995). Quantitative morphometric analysis of trabecular bone architecture in feline mucopolysaccharidosis VI. Immunology and Cell Biology, A13, A13.
1994 Wirth, T., Byers, S., Byard, R., Hopwood, J., & Foster, B. (1994). The implantation of cartilaginous and periosteal tissue into growth plate defects. International Orthopaedics, 18(4), 220-228.
DOI Scopus24 Europe PMC12
1993 Byard, R., Foster, B., & Byers, S. (1993). Immunohistochemical characterisation of the costochondral junction in SIDS. Journal of Clinical Pathology, 46(2), 108-112.
DOI Scopus4 WoS2 Europe PMC2
1992 Byers, S., Caterson, B., Hopwood, J., & Foster, B. (1992). Immunolocation analysis of glycosaminoglycans in the human growth plate. Journal of Histochemistry and Cytochemistry, 40(2), 275-282.
DOI Scopus45 WoS43 Europe PMC25
1987 Byers, S., Hopkins, T., Kuettner, K., & Kimura, J. (1987). The effect of zwitterionic detergents on the extraction and functional properties of cartilage proteoglycans.. The Journal of biological chemistry, 262(19), 9166-9174.
Europe PMC6
1985 Byers, S., Handley, C., Lowther, D., & Sriratana, A. (1985). Carrageenin-induced arthritis. VI. Alterations in amino acid transport by articular cartilage in acute inflammatory arthritis.. Annals of the rheumatic diseases, 44(7), 477-484.
DOI Europe PMC3
1983 Byers, S., Handley, C., & Lowther, D. (1983). Transport of neutral amino acids by adult articular cartilage.. Connective tissue research, 11(4), 321-330.
DOI Europe PMC2

Book Chapters

Year Citation
2005 Byers, S., Lee, J., Fietz, M., & Thomas, B. (2005). Characterisation of human hyaluronidase 1.. In E. A. Balazs, & V. C. Hascall (Eds.), Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications (Vol. 1, 1 ed., pp. 225-228).
2005 Adams, J. R. J., & Byers, S. (2005). Hyaluronan metabolism in the MG63 osteoblast cell line.. In E. A. Balazs (Ed.), Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications (pp. 459-463).
1995 Byard, R. W., Fazzalari, N. L., Byers, S., Moore, A., Wisdon, C., Makrides, M., . . . Gibson, R. A. (1995). Studies of bone growth and cerebral lipid levels in SIDS.. In T. O. Rognum (Ed.), Sudden Infant Death Syndrome. New Trends in the Nineties (pp. 242-244).

Conference Papers

Year Citation
2017 Byers, S., Jiang, Z., Reichstein, C., & Derrick-Roberts, A. L. (2017). Cell cycle progression is disrupted in murine MPS VII growth plate chondrocytes. In MOLECULAR GENETICS AND METABOLISM Vol. 120 (pp. S33). San Diego, CA: ACADEMIC PRESS INC ELSEVIER SCIENCE.
DOI
2016 Jiang, Z., Rossouw, C., Reichstein, C., Macsai, C. E., Jackson, M. R., Derrick-Roberts, A. L., & Byers, S. (2016). Reduced chondrocyte proliferation and hypertrophy contribute to delayed endochondral bone formation in murine mucopolysaccharidosis VII. In MOLECULAR GENETICS AND METABOLISM Vol. 117 (pp. S62-S63). San Diego, CA: ACADEMIC PRESS INC ELSEVIER SCIENCE.
DOI
2015 Byers, S., Pout-Pitt, N., Linard, H., Ainslie, L., & Roberts, S. D. (2015). MPS GAG modulate mesenchymal stem cell differentiation. In MOLECULAR GENETICS AND METABOLISM Vol. 114 (pp. S27-S28). Orlando, FL: ACADEMIC PRESS INC ELSEVIER SCIENCE.
DOI
2015 Jackson, M., Roberts, A. D., Gronthos, S., & Byers, S. (2015). IDURONIDASE TRANSDUCED MSCS IMPROVE THE BEHAVIOURAL DEFICITS IN MUCOPOLYSACCHARIDOSIS I MICE WITH LIMITED BIOCHEMICAL CORRECTIONS. In JOURNAL OF GENE MEDICINE Vol. 17 (pp. 197-198). Univ Melbourne, Univ Coll, Parkville, AUSTRALIA: WILEY-BLACKWELL.
2015 Jackson, M., Robertsa, A., Gronthos, S., & Byers, S. (2015). α-l-Iduronidase transduced mesenchymal stem cells improve the behavioral deficits in mucopolysaccharidosis type I mice. In Abstracts Molecular Genetics and Metabolism Vol. 114 (pp. S58). Orlando, FL: Elsevier.
DOI
2009 Byers, S., Fazzalari, N., Hopwood, J., & Hein, L. (2009). Progression of skeletal disease in MPS disorders. In BONE Vol. 44 (pp. S122). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC.
DOI

Current Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2015 Principal Supervisor The Effect of Glycosaminoglycans from Mucopolysaccharidosis on Neurogenesis Doctor of Philosophy Doctorate Full Time Rebecca Jayne Lehmann
2014 Principal Supervisor The Mechanism of Growth Failure in MPS Doctor of Philosophy Doctorate Full Time Miss Zhirui Jiang

Past Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2011 - 2015 Principal Supervisor The Effects of Undergraded Glycosaminoglycans from Mucopolysaccharidoses on Osteoblast Differentiation and Mineralisation In Vitro Doctor of Philosophy Doctorate Full Time Dr Nathan Bradley Rout-Pitt
2010 - 2015 Principal Supervisor ALPHA-L-IDURONIDASE TRANSDUCED MESENCHYMAL STEM CELLS AS A THERAPY FOR THE TREATMENT OF CNS DEGENERATION IN MUCOPOLYSACCHARIDOSIS TYPE I MICE Doctor of Philosophy Doctorate Full Time Dr Matilda Jackson
2008 - 2014 Principal Supervisor Development of neuropathology in murine MPS IIIA and MPS VII and the effect of N-butyldeoxynojirimycin treatment on MPS IIIA mice Doctor of Philosophy Doctorate Full Time Miss Xenia Kaidonis
2006 - 2014 Co-Supervisor Lentiviral-mediated Gene Therapy for Mucopolysaccharidosis Type IIIA Doctor of Philosophy Doctorate Full Time Ms Chantelle McIntyre
2005 - 2008 Co-Supervisor Structure and Function of the Elastic Fibre Network of the Human Lumbar Anulus Fibrosus Doctor of Philosophy Doctorate Full Time Mr Lachlan Smith
2003 - 2007 Principal Supervisor Substrate Deprivation as a Novel Therapy for the Mucopolysaccharidoses Doctor of Philosophy Doctorate Full Time Miss Ainslie Derrick Roberts
2002 - 2005 Co-Supervisor Formation of Ovarian Follicular Fluid Doctor of Philosophy Doctorate Part Time Ms Hannah Clarke
2001 - 2007 Principal Supervisor Characterisation of Recombinant Hyaluronidase-1 and -3, and of Hyaluronan turnover in Mineralising Osteoblasts Doctor of Philosophy Doctorate Full Time Mr Julian Adams
1999 - 2004 Co-Supervisor The Effect of Recombinant Human Osteogenic Protein-1 on Growth Plate Repair in a Sheep Model Doctor of Philosophy Doctorate Full Time Ms Belinda Thomas

Other Supervision Activities

Date Role Research Topic Location Program Supervision Type Student Load Student Name
2018 - ongoing Principal Supervisor An in vitro model to study growth plate function. The University of Adelaide Honours Daniel Deverson
2017 - 2017 Principal Supervisor Does GH or iGF1 promote bone growth in MPS VII mice ? The University of Adelaide Honours Niemal Usmani
2016 - 2016 Principal Supervisor Development of human in vitro models of MPS IVA skeletal pathology. The University of Adelaide Honours Srimayee Viadanathan
1998 - 2003 Principal Supervisor Characterisation of osteoblast function in a feline model of MPS VI. The University of Adelaide Higher Doctorate Krystyne Zarrinkalam

Committee Memberships

Date Role Committee Institution Country
2016 - ongoing Member IBC Womens and Children's Health Network Australia
2013 - ongoing Member SPDF funding committee SA Pathology Australia
2010 - ongoing Member Radiation Safety Committee SA Pathology Australia
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