Sharon Byers

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

I am Head of the Matrix Biology Unit, Genetics and Molecular Pathology, SA Pathology (WCH site). My overall area of research interest is the role of complex carbohydrates (glycosaminoglycans) in growth, development and disease. A major focus is the development and testing of novel therapies for the treatment of skeletal disease in the mucopolysaccharidoses, a group of genetic disorders arising from impaired glycosaminoglycan turnover.

Career
Publications
Supervision
Professional Activities
Contact

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Appointments

Date	Position	Institution name
2007	Affiliate Senior Lecturer	University of Adelaide, Adelaide
1999	Head, Matrix Biology Unit	SA Pathology (WCH site)
1995	Affiliate Senior Lecturer	University of Adelaide, Adelaide
1993 - 1999	Grant Funded Scientist	Women's and Children's Hospital, Adelaide
1989 - 1992	Senior Research Officer	Women's and Children's Hospital, Adelaide
1987 - 1988	Assistant Professor	West Virginia University, Morgantown

Education

Date	Institution name	Country	Title
1980 - 1984	Monash University, Melbourne	Australia	PhD
1979 - 1979	Monash University, Melbourne	Australia	BSc (hons)
1976 - 1978	Monash University, Melbourne	Australia	BSc

Postgraduate Training

Date Title Institution Country
1983 - 1987 Postdoctoral Fellow Rush University Medical Center, Chicago United States
Research Interests

Biochemistry and Cell Biology Bone and Bones Gene and Molecular Therapy Genetics Medical Biochemistry: Carbohydrates Orthopaedics Child and Adolescent Health Early Origins of Health Musculoskeletal Health

Date	Title	Institution	Country
1983 - 1987	Postdoctoral Fellow	Rush University Medical Center, Chicago	United States

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Journals

Year	Citation
2020	Jiang, Z., Derrick-Roberts, A., Reichstein, C., & Byers, S. (2020). Cell cycle progression is disrupted in murine MPS VII growth plate leading to reduced chondrocyte proliferation and transition to hypertrophy. Bone, 132, 10 pages. DOI Scopus4 WoS2
2020	Derrick-Roberts, A., Kaidonis, X., Jackson, M. R., Liaw, W. C., Ding, X. D., Ong, C., . . . Byers, S. (2020). Comparative analysis of brain pathology in heparan sulphate storing mucopolysaccharidoses. Molecular Genetics and Metabolism. DOI
2020	Jiang, Z., Byers, S., Casal, M. L., & Smith, L. J. (2020). Failures of Endochondral Ossification in the Mucopolysaccharidoses. Current Osteoporosis Reports. DOI
2020	Jiang, Z., Derrick-Roberts, A. L. K., & Byers, S. (2020). Altered IHH signaling contributes to reduced chondrocyte proliferation in the growth plate of MPS VII mice. Molecular Genetics and Metabolism Reports, 25, 100668. DOI
2018	Jiang, Z., Derrick-Roberts, A., Jackson, M., Rossouw, C., Pyragius, C., Xian, C., . . . Byers, S. (2018). Delayed development of ossification centers in the tibia of prenatal and early postnatal MPS VII mice. Molecular Genetics and Metabolism, 124(2), 135-142. DOI Scopus7 WoS6 Europe PMC3
2017	Derrick Roberts, A., Jackson, M., Pyragius, C., & Byers, S. (2017). Substrate deprivation therapy to reduce glycosaminoglycan synthesis improves aspects of neurological and skeletal pathology in MPS I mice. Diseases, 5(1), 5-1-5-16. DOI Europe PMC3
2016	Kaidonis, X., Byers, S., Ranieri, E., Sharp, P., Fletcher, J., & Derrick-Roberts, A. (2016). N-butyldeoxynojirimycin treatment restores the innate fear response and improves learning in mucopolysaccharidosis IIIA mice. Molecular Genetics and Metabolism, 118(2), 100-110. DOI Scopus4 WoS3 Europe PMC3
2016	Derrick-Roberts, A., Panir, K., Pyragius, C., Zarrinkalam, K., Atkins, G., & Byers, S. (2016). Reversal of established bone pathology in MPS VII mice following lentiviral-mediated gene therapy. Molecular Genetics and Metabolism, 119(3), 249-257. DOI Scopus9 WoS6 Europe PMC4
2015	Jackson, M., Derrick Roberts, A., Martin, E., Rout-Pitt, N., Gronthos, S., & Byers, S. (2015). Mucopolysaccharidosis enzyme production by bone marrow and dental pulp derived human mesenchymal stem cells. Molecular Genetics and Metabolism, 114(4), 584-593. DOI Scopus4 WoS4 Europe PMC2
2014	Mcintyre, C., Derrick-Roberts, A., Byers, S., & Anson, D. (2014). Correction of murine mucopolysaccharidosis type IIIA central nervous system pathology by intracerebroventricular lentiviral-mediated gene delivery. Journal of Gene Medicine, 16(11-12), 374-387. DOI Scopus11 WoS8 Europe PMC6
2014	Derrick-Roberts, A., Pyragius, C., Kaidonis, X., Jackson, M., Anson, D., & Byers, S. (2014). Lentiviral-mediated gene therapy results in sustained expression of β-Glucuronidase for up to 12 Months in the Gus mps/mps and up to 18 Months in the Gus tm(L175F)Sly mouse models of mucopolysaccharidosis type VII. Human Gene Therapy, 25(9), 798-810. DOI Scopus16 WoS14 Europe PMC8
2012	Derrick Roberts, A., Marais, W., & Byers, S. (2012). Rhodamine B and 2-acetamido-1,3,6-tri-O-acetyl-4-deoxy-4-fluoro-D-glucopyranose(F-GlcNAc) inhibit chondroitin/dermatan and keratan sulphate synthesis by different mechanisms in bovine chondrocytes. Molecular Genetics and Metabolism, 106(2), 214-220. DOI Scopus8 WoS8 Europe PMC3
2012	Pyragius, C., Derrick Roberts, A., Ding, X., Zarrinkalam, K., McIntyre, C., Anderson, P., . . . Byers, S. (2012). Skeletal response to lentiviral mediated gene therapy in a mouse model of MPS VII. Molecular Genetics and Metabolism, 106(2), 202-213. DOI Scopus24 WoS22 Europe PMC14
2011	Anson, D., McIntyre, C., & Byers, S. (2011). Therapies for neurological disease in the mucopolysaccharidoses. Current Gene Therapy, 11(2), 132-143. DOI Scopus14 WoS14 Europe PMC9
2010	McIntyre, C., Byers, S., & Anson, D. (2010). Correction of mucopolysaccharidosis type IIIA somatic and central nervous system pathology by lentiviral-mediated gene transfer. Journal of Gene Medicine, 12(9), 717-728. DOI Scopus31 WoS28 Europe PMC16
2010	Derrick Roberts, A., Fletcher, J., Moore, L., & Byers, S. (2010). Trans-generational exposure to low levels of rhodamine B does not adversely affect litter size or liver function in murine mucopolysaccharidosis type IIIA. Molecular Genetics and Metabolism, 101(2-3), 208-213. DOI Scopus18 WoS19 Europe PMC10
2010	Kaidonis, X., Liaw, W., Derrick Roberts, A., Ly, M., Anson, D., & Byers, S. (2010). Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses. European Journal of Human Genetics, 18(2), 194-199. DOI Scopus31 WoS27 Europe PMC19
2010	Auclair, D., Ketteridge, D., Oates, S., Hopwood, J. J., & Byers, S. (2010). An overview of intra-articular therapy for mucopolysaccharidosis VI. Journal of Pediatric Rehabilitation Medicine, 3(1), 3-6. DOI Scopus5 Europe PMC3
2009	Byers, S., Rothe, M., Lalic, J., Koldej, R., & Anson, D. (2009). Lentiviral-mediated correction of MPS VI cells and gene transfer to joint tissues. Molecular Genetics and Metabolism, 97(2), 102-108. DOI Scopus19 WoS16 Europe PMC8
2009	Derrick Roberts, A., Howarth, G., Liaw, W., Moretta, S., Kritas, S., Lymn, K., . . . Byers, S. (2009). Gastrointestinal Pathology in a Mouse Model of Mucopolysaccharidosis Type IIIA. Journal of Cellular Physiology, 219(2), 259-264. DOI Scopus10 WoS7 Europe PMC4
2008	Atmuri, V., Martin, D., Hemming, R., Gutsol, A., Byers, S., Sahebjam, S., . . . Triggs-Raine, B. (2008). Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of hyaluronan accumulation. Matrix Biology, 27(8), 653-660. DOI Scopus45 WoS37 Europe PMC33
2008	Sakko, A., Butler, M., Byers, S., Reinboth, B., Stahl, C., Kench, J., . . . Ricciardelli, C. (2008). Immunohistochemical level of unsulfated chondroitin disaccharides in the cancer stroma is an independent predictor of prostate cancer relapse. Cancer Epidemiology Biomarkers & Prevention, 17(9), 2488-2497. DOI Scopus23 WoS23 Europe PMC12
2008	Martin, D., Atmuri, V., Hemming, R., Farley, J., Mort, J., Byers, S., . . . Triggs-Raine, B. (2008). A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis. Human Molecular Genetics, 17(13), 1904-1915. DOI Scopus59 WoS55 Europe PMC42
2008	McIntyre, C., Derrick Roberts, A., Ranieri, E., Clements, P., Byers, S., & Anson, D. (2008). Lentiviral-mediated gene therapy for murine mucopolysaccharidosis type IIIA. Molecular Genetics and Metabolism, 93(4), 411-418. DOI Scopus27 WoS28 Europe PMC17
2008	Bastow, E., Byers, S., Golub, S., Clarkin, C., Pitsillides, A., & Fosang, A. (2008). Hyaluronan synthesis and degradation in cartilage and bone. Cellular and Molecular Life Sciences, 65(3), 395-413. DOI Scopus113 WoS106 Europe PMC64
2008	Smith, L., Byers, S., Costi, J., & Fazzalari, N. (2008). Elastic fibers enhance the mechanical integrity of the human lumbar anulus fibrosus in the radial direction. Annals of Biomedical Engineering, 36(2), 214-223. DOI Scopus49 WoS49 Europe PMC32
2008	Martin, D. C., Atmuri, V., Hemming, R. J., Farley, J., Mort, J. S., Byers, S., . . . Triggs-Raine, B. L. (2008). Erratum: A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis (Human Molecular Genetics (2008) vol. 17 (13) (1904-1915) 10.1093/hmg/ddn088). Human Molecular Genetics, 17(18), 2919. DOI
2007	Anson, D., McIntyre, C., Thomas, B., Koldej, R., Ranieri, E., Derrick Roberts, A., . . . Byers, S. (2007). Lentiviral-mediated gene correction of mucopolysaccharidosis type IIIA. Genetic Vaccines and Therapy, 5(6), WWW 1-WWW 8. DOI Scopus16 Europe PMC16
2007	Derrick Roberts, A., Rees, M., Klebe, S., Fletcher, J., & Byers, S. (2007). Improvement in behaviour after substrate deprivation therapy with rhodamine B in a mouse model of NIPSIIIA. Molecular Genetics and Metabolism, 92(1-2), 115-121. DOI Scopus58 WoS54 Europe PMC37
2007	Auclair, D., Hopwood, J., Lemontt, J., Chen, L., & Byers, S. (2007). Long-term intra-articular administration of recombinant human N-acetylgalactosamine-4-sulfatase in feline mucopolysaccharidosis VI. Molecular Genetics and Metabolism, 91(4), 352-361. DOI Scopus25 WoS22 Europe PMC13
2007	Ricciardelli, C., Russell, D., Ween, M., Mayne, K., Suwiwat, S., Byers, S., . . . Horsfall, D. (2007). Formation of hyaluronan- and versican-rich pericellular matrix by prostate cancer cells promotes cell motility. Journal of Biological Chemistry, 282(14), 10814-10825. DOI Scopus112 WoS111 Europe PMC83
2006	Derrick Roberts, A., Thomas, B., Wilkinson, A., Fletcher, J., & Byers, S. (2006). Inhibition of glycosaminoglycan synthesis using rhodamine B in a mouse model of mucopolysaccharidosis type IIIA. Pediatric Research, 60(3), 309-314. DOI Scopus67 WoS60 Europe PMC39
2006	Clarke, H., Hope, S., Byers, S., & Rodgers, R. (2006). Formation of ovarian follicular fluid may be due to the osmotic potential of large glycosaminoglycans and proteoglycans. Reproduction, 132(1), 119-131. DOI Scopus41 WoS39 Europe PMC24
2006	Auclair, D., Hein, L., Hopwood, J., & Byers, S. (2006). Intra-articular enzyme administration for joint disease in feline mucopolysaccharidosis VI: Enzyme dose and interval. Pediatric Research, 59(4 Part 1), 538-543. DOI Scopus28 WoS28 Europe PMC10
2006	Adams, J., Sander, G., & Byers, S. (2006). Expression of hyaluronan synthases and hyaluronidases in the MG63 osteoblast cell line. Matrix Biology, 25(1), 40-46. DOI Scopus7 WoS9 Europe PMC5
2005	Thomas, B., Byers, S., Johnstone, E., & Foster, B. (2005). The effect of recombinant human osteogenic protein-1 on growth plate repair in a sheep model. Journal of Orthopaedic Research, 23(6), 1336-1344. DOI Scopus5 WoS5 Europe PMC4
2004	Crawley, A., Ramsay, S., Byers, S., Hopwood, J., & Meikle, P. (2004). Monitoring dose response of enzyme replacement therapy in feline mucopolysaccharidosis type VI by tandem mass spectrometry. Pediatric Research, 55(4), 585-591. DOI Scopus24 WoS20 Europe PMC10
2002	Johnstone, E., McArthur, M., Solly, P., Higginson, K., Byers, S., & Foster, B. (2002). The effect of osteogenic protein-1 in an in vivo physeal injury model. Clinical Orthopaedics and Related Research, 395(395), 234-240. DOI Scopus13 WoS9 Europe PMC5
2000	Johnstone, E., Leane, P., Byers, S., Hopwood, J., & Foster, B. (2000). Metaphyseal factors promote calcium incorporation in physeal chondrocyte cultures. Journal of Orthopaedic Science, 5(6), 593-599. DOI Scopus1 Europe PMC1
2000	Johnstone, E., Leane, P., Kolesik, P., Byers, S., & Foster, B. (2000). Spatial arrangement of physeal cartilage chondrocytes and the structure of the primary spongiosa. Journal of Orthopaedic Science, 5(3), 294-301. DOI Scopus10 Europe PMC5
2000	Byers, S., Crawley, A., Brumfield, L., Nuttall, J., & Hopwood, J. (2000). Enzyme replacement therapy in a feline model of MPS VI: Modification of enzyme structure and dose frequency. Pediatric Research, 47(6), 743-749. DOI Scopus31 WoS29 Europe PMC17
2000	Byers, S., Moore, A., Byard, R., & Fazzalari, N. (2000). Quantative histomorphometric analysis of the human growth plate from birth to adolescence. Bone, 27(4), 495-501. DOI Scopus69 WoS58 Europe PMC41
2000	McArthur, M., Irving-Rodgers, H., Byers, S., & Rodgers, R. (2000). Identification and immunolocalization of decorin, versican, perlecan, nidogen, and chondroitin sulfate proteoglycans in bovine small-antral ovarian follicles. Biology of Reproduction, 63(3), 913-924. DOI Scopus60 WoS58 Europe PMC39
1999	Perkins, K., Byers, S., Yogalingam, G., Weber, B., & Hopwood, J. (1999). Expression and characterization of wild type and mutant recombinant human sulfamidase - Implications for Sanfilippo (mucopolysaccharidosis IIIA) syndrome. Journal of Biological Chemistry, 274(52), 37193-37199. DOI Scopus35 WoS31 Europe PMC23
1999	Nuttall, J., Brumfield, L., Fazzalari, N., Hopwood, J., & Byers, S. (1999). Histomorphometric analysis of the tibial growth plate in a feline model of mucopolysaccharidosis type VI. Calcified Tissue International, 65(1), 47-52. DOI Scopus38 WoS37 Europe PMC27
1998	Bunge, S., Clements, P., Byers, S., Kleijer, W., Brooks, D., & Hopwood, J. (1998). Genotype-phenotype correlations in mucopolysaccharidosis type I using enzyme kinetics, immunoquantification and in vitro turnover studies. Biochimica et Biophysica Acta, 1407(3), 249-256. DOI Scopus58 WoS53 Europe PMC44
1998	Byard, R., Byers, S., Moore, A., Leppard, P., & Fazzalari, N. (1998). Morphometric assessment of bone and growth plate in sudden infant death syndrome. Journal of Sudden Infant Death Syndrome and Infant Mortality, 2(3), 151-160. Scopus2
1998	Jones, M., Brumfield, L., King, B., Hopwood, J., & Byers, S. (1998). Recombinant caprine <sup>3</sup>H-[N-acetylglucosamine-6-sulfatase] and human <sup>3</sup>H- [N-acetylgalactosamine-4-sulfatase]: Plasma clearance, tissue distribution, and cellular uptake in the rat. Journal of Molecular Neuroscience, 11(3), 223-232. DOI Scopus6 WoS6 Europe PMC4
1998	Byers, S., Rozaklis, T., Brumfield, L., Ranieri, E., & Hopwood, J. (1998). Glycosaminoglycan accumulation and excretion in the mucopolysaccharidoses: Characterization and basis of a diagnostic test for MPS. Molecular Genetics and Metabolism, 65(4), 282-290. DOI Scopus59 WoS55 Europe PMC44
1997	Byers, S., Nuttall, J., Crawley, A., Hopwood, J., Smith, K., & Fazzalari, N. (1997). Effect of enzyme replacement therapy on bone formation in a feline model of mucopolysaccharidosis Type VI. Bone, 21(5), 425-431. DOI Scopus51 WoS49 Europe PMC31
1997	Fazzalari, N., Moore, A., Byers, S., & Byard, R. (1997). Quantitative analysis of trabecular morphogenesis in the human costochondral junction during the postnatal period in normal subjects. The Anatomical Record, 248(1), 1-12. DOI Scopus36 WoS32 Europe PMC28
1997	Brooks, D., King, B., Crawley, A., Byers, S., & Hopwood, J. (1997). Enzyme replacement therapy in Mucopolysaccharidosis VI: evidence for immune responses and altered efficacy of treatment in animal models. Biochimica et Biophysica Acta, 1361(2), 203-216. DOI Scopus35 WoS34 Europe PMC20
1997	Byers, S., van Rooden, J., & Foster, B. (1997). Structural changes in the large proteoglycan, aggrecan, in different zones of the ovine growth plate. Calcified Tissue International, 60(1), 71-78. DOI Scopus26 WoS23 Europe PMC16
1997	Crawley, A., Niedzielski, K., Isaac, E., Davey, R., Byers, S., & Hopwood, J. (1997). Enzyme replacement therapy from birth in a feline model of mucopolysaccharidosis type VI. Journal of Clinical Investigation, 99(4), 651-662. DOI Scopus101 WoS101 Europe PMC66
1997	Fazzalari, N., Moore, A., Byers, S., & Byard, R. (1997). Quantitative analysis of trabecular morphogenesis in the human costochondral junction during the postnatal period in normal subjects. The Anatomical Record, 248(1), 1-12. DOI
1996	Crawley, A., Brooks, D., Muller, V., Petersen, B., Isaac, E., Bielicki, J., . . . Hopwood, J. (1996). Enzyme replacement therapy in a feline model of Maroteaux-Lamy syndrome. Journal of Clinical Investigation, 97(8), 1864-1873. DOI Scopus119 WoS115 Europe PMC78
1995	Byard, R., Fazzalari, N., Moore, A., & Byers, S. (1995). Morphometric analysis of the bone growth plate in sudden infant death syndrome. Pathology, 27, S6.
1995	Clarke, J., Byers, S., Moore, A., Fazzalari, N., & Hopwood, J. (1995). Quantitative morphometric analysis of trabecular bone architecture in feline mucopolysaccharidosis VI. Immunology and Cell Biology, A13, A13.
1994	Wirth, T., Byers, S., Byard, R., Hopwood, J., & Foster, B. (1994). The implantation of cartilaginous and periosteal tissue into growth plate defects. International Orthopaedics, 18(4), 220-228. DOI Scopus26 WoS21 Europe PMC14
1993	Byard, R., Foster, B., & Byers, S. (1993). Immunohistochemical characterisation of the costochondral junction in SIDS. Journal of Clinical Pathology, 46(2), 108-112. DOI Scopus4 WoS2 Europe PMC2
1992	Byers, S., Caterson, B., Hopwood, J. J., & Foster, B. K. (1992). Immunolocation analysis of glycosaminoglycans in the human growth plate. Journal of Histochemistry and Cytochemistry, 40(2), 275-282. DOI Scopus46 WoS44 Europe PMC28
1987	BYERS, S., HOPKINS, T. J., KUETTNER, K. E., & KIMURA, J. H. (1987). THE EFFECT OF ZWITTERIONIC DETERGENTS ON THE EXTRACTION AND FUNCTIONAL-PROPERTIES OF CARTILAGE PROTEOGLYCANS. JOURNAL OF BIOLOGICAL CHEMISTRY, 262(19), 9166-9174. WoS12 Europe PMC6
1985	BYERS, S., HANDLEY, C. J., LOWTHER, D. A., & SRIRATANA, A. (1985). CARRAGEENIN-INDUCED ARTHRITIS .6. ALTERATIONS IN AMINO-ACID TRANSPORT BY ARTICULAR-CARTILAGE IN ACUTE INFLAMMATORY ARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES, 44(7), 477-484. DOI WoS3 Europe PMC3
1983	BYERS, S., HANDLEY, C. J., & LOWTHER, D. A. (1983). TRANSPORT OF NEUTRAL AMINO-ACIDS BY ADULT ARTICULAR-CARTILAGE. CONNECTIVE TISSUE RESEARCH, 11(4), 321-330. DOI WoS6 Europe PMC2

Book Chapters

Year	Citation
2005	Byers, S., Lee, J., Fietz, M., & Thomas, B. (2005). Characterisation of human hyaluronidase 1.. In E. A. Balazs, & V. C. Hascall (Eds.), Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications (Vol. 1, 1 ed., pp. 225-228).
2005	Adams, J. R. J., & Byers, S. (2005). Hyaluronan metabolism in the MG63 osteoblast cell line.. In E. A. Balazs (Ed.), Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications (pp. 459-463).
1995	Byard, R. W., Fazzalari, N. L., Byers, S., Moore, A., Wisdon, C., Makrides, M., . . . Gibson, R. A. (1995). Studies of bone growth and cerebral lipid levels in SIDS.. In T. O. Rognum (Ed.), Sudden Infant Death Syndrome. New Trends in the Nineties (pp. 242-244).

Conference Papers

Year	Citation
2017	Byers, S., Jiang, Z., Reichstein, C., & Derrick-Roberts, A. L. K. (2017). Cell cycle progression is disrupted in murine MPS VII growth plate chondrocytes. In MOLECULAR GENETICS AND METABOLISM Vol. 120 (pp. S33). San Diego, CA: ACADEMIC PRESS INC ELSEVIER SCIENCE. DOI
2016	Jiang, Z., Rossouw, C., Reichstein, C., Macsai, C. E., Jackson, M. R., Derrick-Roberts, A. L. K., & Byers, S. (2016). Reduced chondrocyte proliferation and hypertrophy contribute to delayed endochondral bone formation in murine mucopolysaccharidosis VII. In MOLECULAR GENETICS AND METABOLISM Vol. 117 (pp. S62-S63). San Diego, CA: ACADEMIC PRESS INC ELSEVIER SCIENCE. DOI
2015	Byers, S., Pout-Pitt, N., Linard, H., Ainslie, L. K., & Roberts, S. A. D. (2015). MPS GAG modulate mesenchymal stem cell differentiation. In MOLECULAR GENETICS AND METABOLISM Vol. 114 (pp. S27-S28). Orlando, FL: ACADEMIC PRESS INC ELSEVIER SCIENCE. DOI
2015	Jackson, M., Roberts, A. D., Gronthos, S., & Byers, S. (2015). IDURONIDASE TRANSDUCED MSCS IMPROVE THE BEHAVIOURAL DEFICITS IN MUCOPOLYSACCHARIDOSIS I MICE WITH LIMITED BIOCHEMICAL CORRECTIONS. In JOURNAL OF GENE MEDICINE Vol. 17 (pp. 197-198). Univ Melbourne, Univ Coll, Parkville, AUSTRALIA: WILEY-BLACKWELL.
2015	Jackson, M., Robertsa, A., Gronthos, S., & Byers, S. (2015). α-l-Iduronidase transduced mesenchymal stem cells improve the behavioral deficits in mucopolysaccharidosis type I mice. In Abstracts Molecular Genetics and Metabolism Vol. 114 (pp. S58). Orlando, FL: Elsevier. DOI
2015	Byers, S., Pyragius, C., Panir, K., Anson, D., & Roberts, A. D. (2015). LENTIVIRAL-MEDIATED GENE THERAPY IN THE MUCOPOLYSACCHARIDOSIS TYPE VII MOUSE. In JOURNAL OF GENE MEDICINE Vol. 17 (pp. 198). Univ Melbourne, Univ Coll, Parkville, AUSTRALIA: WILEY-BLACKWELL.
2015	McIntyre, C., Byers, S., & Anson, D. (2015). REPORTER AND THERAPEUTIC GENE TRANSFER TO THE BRAINS OF NORMAL AND MUCOPOLYSACCHARIDOSIS IIIA MICE, RESPECTIVELY, FOLLOWING INTRACEREBROVENTRICULAR DELIVERY OF LENTIVIRUS. In JOURNAL OF GENE MEDICINE Vol. 17 (pp. 196). Univ Melbourne, Univ Coll, Parkville, AUSTRALIA: WILEY-BLACKWELL.
2009	Byers, S., Fazzalari, N. L., Hopwood, J. J., & Hein, L. K. (2009). Progression of skeletal disease in MPS disorders. In BONE Vol. 44 (pp. S122). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC. DOI
2007	Smith, L. J., Byers, S., Costi, J. J., & Fazzalari, N. L. (2007). The roles of elastic fibres and glycosaminoglycans in the radial tensile mechanics of the human lumbar anulus fibrosus. In Proceedings of the ASME Summer Bioengineering Conference 2007, SBC 2007 (pp. 875-876). Keystone, CO: AMER SOC MECHANICAL ENGINEERS. DOI

Conference Items

Year	Citation
2018	Byers, S., Rout-Pitt, N., Linard, H., Vaidyanathan, S., & Derrick-Roberts, A. L. (2018). MESENCHYMAL STEM CELL DIFFERENTIATION IS MODULATED BY COMPLEX SUGARS IN MPS DISEASE. Poster session presented at the meeting of JOURNAL OF GENE MEDICINE. Univ Technol Sydney, Sydney, AUSTRALIA: WILEY.

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Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2015 - 2019	Principal Supervisor	The Neurogenic Potential of Stem Cells is Altered in Mucopolysaccharidosis Type IIIA	Doctor of Philosophy	Doctorate	Full Time	Rebecca Jayne Lehmann
2014 - 2018	Principal Supervisor	Mechanisms of Growth Failure in Mucopolysaccharidosis VII Mice	Doctor of Philosophy	Doctorate	Full Time	Miss Zhirui Jiang
2011 - 2015	Principal Supervisor	The Effects of Undergraded Glycosaminoglycans from Mucopolysaccharidoses on Osteoblast Differentiation and Mineralisation In Vitro	Doctor of Philosophy	Doctorate	Full Time	Dr Nathan Bradley Rout-Pitt
2010 - 2015	Principal Supervisor	ALPHA-L-IDURONIDASE TRANSDUCED MESENCHYMAL STEM CELLS AS A THERAPY FOR THE TREATMENT OF CNS DEGENERATION IN MUCOPOLYSACCHARIDOSIS TYPE I MICE	Doctor of Philosophy	Doctorate	Full Time	Dr Matilda Jackson
2008 - 2014	Principal Supervisor	Development of neuropathology in murine MPS IIIA and MPS VII and the effect of N-butyldeoxynojirimycin treatment on MPS IIIA mice	Doctor of Philosophy	Doctorate	Full Time	Miss Xenia Kaidonis
2006 - 2014	Co-Supervisor	Lentiviral-mediated Gene Therapy for Mucopolysaccharidosis Type IIIA	Doctor of Philosophy	Doctorate	Full Time	Dr Chantelle McIntyre
2005 - 2008	Co-Supervisor	Structure and Function of the Elastic Fibre Network of the Human Lumbar Anulus Fibrosus	Doctor of Philosophy	Doctorate	Full Time	Mr Lachlan Smith
2003 - 2007	Principal Supervisor	Substrate Deprivation as a Novel Therapy for the Mucopolysaccharidoses	Doctor of Philosophy	Doctorate	Full Time	Miss Ainslie Derrick Roberts
2002 - 2005	Co-Supervisor	Formation of Ovarian Follicular Fluid	Doctor of Philosophy	Doctorate	Part Time	Ms Hannah Clarke
2001 - 2007	Principal Supervisor	Characterisation of Recombinant Hyaluronidase-1 and -3, and of Hyaluronan turnover in Mineralising Osteoblasts	Doctor of Philosophy	Doctorate	Full Time	Mr Julian Adams
1999 - 2004	Co-Supervisor	The Effect of Recombinant Human Osteogenic Protein-1 on Growth Plate Repair in a Sheep Model	Doctor of Philosophy	Doctorate	Full Time	Ms Belinda Thomas

Other Supervision Activities

Date	Role	Research Topic	Location	Program	Supervision Type	Student Load	Student Name
2018 - ongoing	Principal Supervisor	An in vitro model to study growth plate function.	The University of Adelaide	—	Honours	—	Daniel Deverson
2017 - 2017	Principal Supervisor	Does GH or iGF1 promote bone growth in MPS VII mice ?	The University of Adelaide	—	Honours	—	Niemal Usmani
2016 - 2016	Principal Supervisor	Development of human in vitro models of MPS IVA skeletal pathology.	The University of Adelaide	—	Honours	—	Srimayee Viadanathan
1998 - 2003	Principal Supervisor	Characterisation of osteoblast function in a feline model of MPS VI.	The University of Adelaide	—	Higher Doctorate	—	Krystyne Zarrinkalam

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Committee Memberships

Date	Role	Committee	Institution	Country
2016 - ongoing	Member	IBC	Womens and Children's Health Network	Australia
2013 - ongoing	Member	SPDF funding committee	SA Pathology	Australia
2010 - ongoing	Member	Radiation Safety Committee	SA Pathology	Australia

Email: sharon.byers@adelaide.edu.au

Sharon Byers

Appointments

Education

Postgraduate Training

Research Interests

Journals

Book Chapters

Conference Papers

Conference Items

Past Higher Degree by Research Supervision (University of Adelaide)

Other Supervision Activities

Committee Memberships

Connect With Me

External Profiles