Dr Seyyed Moussavi Nik

Seyyed Moussavi Nik
Postdoctoral Research Fellow
School of Biological Sciences
Faculty of Sciences

We are using the latest genome engineering techiques to introduce human Alzheimer's disease mutations into our experimental model, the zebrafish. We then study these mutant zebrafish using "deep sequencing" analysis of gene expression to observe how the mutations change the molecular state of cells in their brains.

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Dr Seyyed Moussavi Nik

We are using the latest genome engineering techiques to introduce human Alzheimer's disease mutations into our experimental model, the zebrafish. We then study these mutant zebrafish using "deep sequencing" analysis of gene expression to observe how the mutations change the molecular state of cells in their brains.

Zebrafish models of familial Alzheimer’s disease for understanding molecular mechanisms and drug discovery.

Goal: We are using the latest genome engineering techiques to introduce human Alzheimer's disease mutations into our experimental model, the zebrafish. We then study these mutant zebrafish using "deep sequencing" analysis of gene expression to observe how the mutations change the molecular state of cells in their brains.
 

 

Appointments

Date Position Institution name
2015 Postdoctoral Research Fellow The Univeristy of Adelaide

Awards and Achievements

Date Type Title Institution Name Amount
2017 Research Award Alzheimer’s Australia Dementia Research Foundation Project Grant Alzheimer’s Australia Dementia Research Foundation
2015 Award Dean’s Commendation for Doctoral Thesis Excellence The Univeriaty of Adelaide
2015 Award The School of Biological Sciences Postgraduate Academic Achievement Award The Univeristy of Adelaide
2015 Award The School of Biological Sciences Postgraduate Writing-up Award The Univeristy of Adelaide
2011 Scholarship University of Adelaide Graduate Research Scholarship The University of Adelaide

Education

Date Institution name Country Title
2011 - 2014 University of Adelaide, Adelaide Australia PhD
2009 - 2011 University of Adelaide, Adelaide Australia M.Sc
2002 - 2006 Ferdowsi University of Mashhad, Mashhad Iran B.Sc

Research Interests

Developmental Genetics, Medical Genetics, Neurogenetics, Neurosciences

Journals

Year Citation
2017 Ebrahimie, , Fruzangohar, , Moussavi Nik, S. & Newman, (2017). Gene Ontology-based analysis of zebrafish’ omics data using the web tool Comparative. Zebrafish, 14, 5, 492-494.
10.1089/zeb.2016.1290
2016 Ebrahimie, E., Moussavi Nik, S., Newman, M., Van Der Hoek, M. & Lardelli, M. (2016). The Zebrafish equivalent of Alzheimer's disease-associated PRESENILIN Isoform PS2V regulates inflammatory and other responses to hypoxic stress. F. Amenta (Ed.). Journal of Alzheimer's Disease, 52, 2, 581-608.
10.3233/JAD-150678
2016 Jayne, T., Newman, M., Verdile, G., Sutherland, G., Münch, G., Musgrave, I. ... Lardelli, M. (2016). Evidence for and against a pathogenic role of reduced γ-secretase activity in familial Alzheimer's disease. M. Murphy (Ed.). Journal of Alzheimer's Disease, 52, 3, 781-799.
10.3233/JAD-151186
2015 Moussavi Nik, S., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I. ... Lardelli, M. (2015). Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity. Human Molecular Genetics, 24, 13, 3662-3678.
10.1093/hmg/ddv110
2015 Lim, A., Moussavi Nik, S., Ebrahimie, E. & Lardelli, M. (2015). Analysis of nicastrin gene phylogeny and expression in zebrafish. Development Genes and Evolution, 225, 3, 171-178.
10.1007/s00427-015-0500-9
2014 Newman, M., Wilson, L., Verdile, G., Lim, A., Khan, I., Nik, S. ... Lardelli, M. (2014). Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease. Human Molecular Genetics, 23, 3, 602-617.
10.1093/hmg/ddt448
2014 Ganesan, S., Moussavi Nik, S., Newman, M. & Lardelli, M. (2014). Identification and expression analysis of the zebrafish orthologues of the mammalian MAP1LC3 gene family. Experimental Cell Research, 328, 1, 228-237.
10.1016/j.yexcr.2014.07.014
2014 Nik, S., Croft, K., Mori, T. & Lardelli, M. (2014). The comparison of methods for measuring oxidative stress in zebrafish brains. Zebrafish, 11, 3, 248-254.
10.1089/zeb.2013.0958
2014 Moussavi Nik, S., Newman, M., Ganesan, S., Chen, M., Martins, R., Verdile, G. & Lardelli, M. (2014). Hypoxia alters expression of Zebrafish Microtubule-associated protein Tau (mapta, maptb) gene transcripts. BMC Research Notes, 7, 1, 767-775.
10.1186/1756-0500-7-767
2013 Sharman, M., Moussavi Nik, S., Chen, M., Ong, D., Wijaya, L., Laws, S. ... Verdile, G. (2013). The Guinea Pig as a model for sporadic Alzheimer's Disease (AD): the impact of cholesterol intake on expression of AD-related genes. PLoS One, 8, 6, 1-12.
10.1371/journal.pone.0066235
2012 Moussavi Nik, S., Wilson, L., Newman, M., Croft, K., Mori, T., Musgrave, I. & Lardelli, M. (2012). The BACE1-PSEN-AβPP regulatory axis has an ancient role in response to low oxygen/oxidative stress. Journal of Alzheimer's Disease, 28, 3, 515-530.
10.3233/JAD-2011-110533
2011 Moussavi Nik, S., Newman, M. & Lardelli, M. (2011). The response of HMGA1 to changes in oxygen availability is evolutionarily conserved. Experimental Cell Research, 317, 11, 1503-1512.
10.1016/j.yexcr.2011.04.004

Conference Papers

Year Citation
2015 Lardelli, M., Ebrahimie, E., Newman, M., Nik, S. & Hoek, M. (2015). Transcriptome analyses using human and zebrafish brain data reveal hypoxia as an important element in Alzheimer's disease. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society. Cairns, AUSTRALIA.
2012 Verdile, G., Sharman, M., Chen, M., Nik, S. M., Ong, D., Wijaya, L. ... Martins, R. (2012). The impact of cholesterol intake on expression of Alzheimer's disease–related genes in the guinea pig brain.
10.1016/j.jalz.2012.05.1278
  • Alzheimer’s Australia Dementia Research Foundation Project Grant (2017) (AUD $50,000)

Project Title: Identifying early molecular changes underlying familial Alzheimer’s disease.

  • The University of Adelaide International Graduate Research Scholarship (2011-2014) (AUD $165,000).

Project Title: Analyzing the biological function of PS2V: An aberrant splicing phenomenon or evolutionary conserved mechanism in Alzheimer’s disease.

Position
Postdoctoral Research Fellow
Phone
83134863
Campus
North Terrace
Org Unit
Genetics & Evolution

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