Sepideh Mehrpour Layeghi

Research Interests

Regenerative medicine (incl. stem cells) Oncology and Carcinogenesis Medical Genetics Cancer Cell Biology Cancer Genetics Bioinformatics and computational biology

Ms Sepideh Mehrpour Layeghi

Higher Degree by Research Candidate

School of Pharmacy and Biomedical Sciences

College of Health

PhD candidate at the The University of Adelaide in the Gene Regulation laboratory of Prof Greg Goodall. My research focuses on identifying molecular drivers of neuroblastoma using human iPSC-based differentiation models and functional genomics approaches, including shRNA and CRISPR-based gene perturbation systems. I am particularly interested in transcriptional regulation during sympathetic neuronal development and cancer progression. 
With a Bachelor of Science in Cellular and Molecular Biology and a Master of Science in Human Genetics, I also work as a university tutor and demonstrator, teaching human physiology, genetics, biology, and cancer biology across undergraduate courses.

Date Position Institution name
2025 - ongoing University Tutor Adelaide University
2024 - ongoing PhD Candidate Adelaide University

Language Competency
English Can read, write, speak, understand spoken and peer review
Persian Can read, write, speak, understand spoken and peer review

Date Institution name Country Title
2017 - 2020 Tehran University of Medical Sciences Iran M.Sc. in Human Genetics
2012 - 2016 Kharazmi University Iran B.Sc. in Cellular and Molecular Biology

Year Citation
2025 Al Kateb, A., Heidarzadehpilehrood, R., Pirhoushiaran, M., Abdollahzadeh, R., Saffari, M., Majidzadeh A, K., . . . Modarressi, M. H. (2025). Silencing of long non-coding RNAs MIR22HG, LNCTAM34A, and TP53TG1 triggers cell survival/proliferation and inhibits apoptosis in women's breast cancer. Advances in Cancer Biology - Metastasis, 13(100133), 1-9.
DOI
2023 Arabpour, M., Mehrpour Layeghi, S., Majidzadeh-A, K., Tavakkoly Bazzaz, J., Mamivand, A., Naghizadeh, M. M., & Shakoori, A. (2023). An insight into the potential role of LINC00968 in luminal breast cancer: Case-control study and bioinformatics analysis. Biochemistry and Biophysics Reports, 35, 101531.
DOI Scopus1 Europe PMC1
2023 Sadeghirad, H., Bahrami, T., Layeghi, S. M., Yousefi, H., Rezaei, M., Hosseini‐Fard, S. R., . . . Kulasinghe, A. (2023). Immunotherapeutic targets in non‐small cell lung cancer. Immunology, 168(2), 256-272.
DOI Europe PMC12
2021 Mehrpour Layeghi, S., Arabpour, M., Shakoori, A., Naghizadeh, M. M., Mansoori, Y., Tavakkoly Bazzaz, J., & Esmaeili, R. (2021). Expression profiles and functional prediction of long non-coding RNAs LINC01133, ZEB1-AS1 and ABHD11-AS1 in the luminal subtype of breast cancer. Journal of Translational Medicine, 19(1), 364.
DOI Scopus13 Europe PMC14
2021 Arabpour, M., Layeghi, S. M., Bazzaz, J. T., Naghizadeh, M. M., Majidzadeh-A, K., & Shakoori, A. (2021). The potential roles of lncRNAs DUXAP8, LINC00963, and FOXD2-AS1 in luminal breast cancer based on expression analysis and bioinformatic approaches. Human Cell, 34(4), 1227-1243.
DOI Scopus8 Europe PMC11
2020 Mehrpour Layeghi, S., Arabpour, M., Esmaeili, R., Naghizadeh, M. M., Tavakkoly Bazzaz, J., & Shakoori, A. (2020). Evaluation of the potential role of long non-coding RNA LINC00961 in luminal breast cancer: A case-control and systems biology study. Cancer Cell International, 20(1), 478.
DOI Scopus9 Europe PMC7
- Salmaninejad, A., Layeghi, S. M., Falakian, Z., Foroushani, P. S., Golestani, S., Pourghazi, F., . . . Yousefi, M. (2026). The role of tumor-associated macrophages in cancer development and their significance as prognostic markers. Clinical and Experimental Medicine, 26(1).
DOI
- Salmaninejad, A., Layeghi, S. M., Falakian, Z., Golestani, S., Kobravi, S., Talebi, S., & Yousefi, M. (2024). An update to experimental and clinical aspects of tumor-associated macrophages in cancer development: hopes and pitfalls. Clinical and Experimental Medicine, 24(1).
DOI

Year Citation
2020 Sajjadi, R. S., Ahmadi, S., Mantashloo, M., Layeghi, S. M., Asgari, Y., Ghorbani, M., . . . Saffari, M. (2020). Combination of arsenic trioxide epigallocatechin-3-gallate and Resveratrol synergistically suppresses the growth and invasion in Brain tumor cell lines.
DOI

Courses I teach

  • BIOL 1007 Biology A (2025)
  • BIOL 1049 Human Physiology 100 (2025)
  • BIOL 1050 Human Physiology 101 (2025)
  • BIOL 2016 Genetics (2025)
  • BIOL 2035 Physiology (2025)
  • HLTH 1070 Introduction to Human Physiology (2025)

Date Topic Location Name
2025 - 2026 Circular RNAs in neuroblastoma Adelaide University Baoguang Cong

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