Dr Scott Smid

• Appointments

  Date	Position	Institution name
  2015 - ongoing	Visiting Fellow	University of Western Australia, Perth
  2012 - ongoing	Deputy Head	University of Adelaide, Adelaide
  2006 - ongoing	Senior Lecturer	University of Adelaide, Adelaide

• Awards and Achievements

  Date	Type	Title	Institution Name	Country	Amount
  2012	Award	Faculty International Conference Award (FICA)

• Education

  Date	Institution name	Country	Title
  1991 - 1994	University of Adelaide, Adelaide	Australia	Doctor of Philosophy
  1990	University of Adelaide, Adelaide	Australia	Honours Degree of Bachelor of Science (Class 1 Honours)
  1979 - 1989	University of Adelaide, Adelaide	Australia	Bachelor of Science

• Research Interests

  Neuroscience, Behaviour and Brain Health Immunology and Infection Innovative Therapeutics

• Journals

  Year	Citation
  2022	Laws, J. S., Shrestha, S., & Smid, S. D. (2022). Cannabis terpenes display variable protective and anti-aggregatory actions against neurotoxic β amyloid in vitro: highlighting the protective bioactivity of α-bisabolol in motorneuronal-like NSC-34 cells. NeuroToxicology, 90, 81-87. DOI
  2022	Shrestha, S., Choi, J. S., Zhang, W., & Smid, S. D. (2022). Neuroprotective activity of macroalgal fucofuroeckols against amyloid β peptide-induced cell death and oxidative stress. International Journal of Food Science and Technology, 1-10. DOI
  2021	Shrestha, S., Zhang, W., & Smid, S. D. (2021). Phlorotannins: A review on biosynthesis, chemistry and bioactivity. Food Bioscience, 39, 100832-1-100832-11. DOI Scopus23 WoS20
  2021	Shrestha, S., Johnston, M. R., Zhang, W., & Smid, S. D. (2021). A phlorotannin isolated from Ecklonia radiata, Dibenzodioxin-fucodiphloroethol, inhibits neurotoxicity and aggregation of β-amyloid. Phytomedicine Plus, 1(4), 100125-1-100125-9. DOI Scopus2
  2021	Dos Reis Franco, G., Smid, S., & Viegas, C. (2021). Phytocannabinoids: General Aspects and Pharmacological Potential in Neurodegenerative Diseases.. Current neuropharmacology, 19(4), 449-464. DOI Scopus1 WoS1
  2020	Marsh, D. T., & Smid, S. D. (2020). Cannabis Phytochemicals: A Review of Phytocannabinoid Chemistry and Bioactivity as Neuroprotective Agents. AUSTRALIAN JOURNAL OF CHEMISTRY, 74(6), 388-404. DOI Scopus1 WoS1
  2020	Jovcevski, B., Das, S., Smid, S., & Pukala, T. L. (2020). Polyphenol honokiol and flavone 2′,3′,4′-trihydroxyflavone differentially interact with α-synuclein at distinct phases of aggregation. ACS Chemical Neuroscience, 11(24), 4469-4477. DOI Scopus3 WoS2
  2020	Alghazwi, M., Charoensiddhi, S., Smid, S., & Zhang, W. (2020). Impact of Ecklonia radiata extracts on the neuroprotective activities against amyloid beta (Aβ<inf>1-42</inf>) toxicity and aggregation. Journal of Functional Foods, 68, 9 pages. DOI Scopus5 WoS7
  2020	Gunasegaran, B., Neilsen, P. M., & Smid, S. D. (2020). P53 activation suppresses irinotecan metabolite SN-38-induced cell damage in non-malignant but not malignant epithelial colonic cells.. Toxicol In Vitro, 67, 104908. DOI Scopus2 WoS2 Europe PMC1
  2020	Shrestha, S., Zhang, W., Begbie, A. J., Pukala, T. L., & Smid, S. D. (2020). Ecklonia radiata extract containing eckol protects neuronal cells against Aβ1-42 evoked toxicity and reduces aggregate density.. Food Funct, 11(7), 6509-6516. DOI Scopus4 WoS4 Europe PMC1
  2019	Eggers, C., Fujitani, M., Kato, R., & Smid, S. (2019). Novel cannabis flavonoid, cannflavin A displays both a hormetic and neuroprotective profile against amyloid β-mediated neurotoxicity in PC12 cells: Comparison with geranylated flavonoids, mimulone and diplacone.. Biochemical pharmacology, 169, 113609. DOI Scopus15 WoS14 Europe PMC5
  2019	Das, S., & Smid, S. D. (2019). Small molecule diketone flavorants diacetyl and 2,3-pentanedione promote neurotoxicity but inhibit amyloid β aggregation. Toxicology Letters, 300, 67-72. DOI Scopus3 WoS3 Europe PMC1
  2019	Alghazwi, M., Smid, S., Karpiniec, S., & Zhang, W. (2019). Comparative study on neuroprotective activities of fucoidans from Fucus vesiculosus and Undaria pinnatifida. International Journal of Biological Macromolecules, 122, 255-264. DOI Scopus13 WoS17 Europe PMC8
  2019	Alghazwi, M., Smid, S., Musgrave, I., & Zhang, W. (2019). In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ₁−₄₂) toxicity and aggregation. Neurochemistry International, 124, 215-224. DOI Scopus43 WoS41 Europe PMC20
  2019	Li, X., Smid, S. D., Lin, J., Gong, Z., Chen, S., You, F., . . . Jin, X. (2019). Neuroprotective and anti-amyloid β effect and main chemical profiles of white tea: Comparison against green, oolong and Black tea. Molecules, 24(10), 1-15. DOI Scopus15 WoS10 Europe PMC5
  2018	Alghazwi, M., Smid, S., & Zhang, W. (2018). In vitro protective activity of South Australian marine sponge and macroalgae extracts against amyloid beta (Aβ₁−₄₂) induced neurotoxicity in PC-12 cells. Neurotoxicology and Teratology, 68, 72-83. DOI Scopus5 WoS5 Europe PMC2
  2018	Das, S., Pukala, T., & Smid, S. (2018). Exploring the structural diversity in inhibitors of α-Synuclein amyloidogenic folding, aggregation, and neurotoxicity. Frontiers in Chemistry, 6(MAY), 181-1-181-12. DOI Scopus11 WoS13 Europe PMC6
  2018	Hofma, B., Wardill, H., Mavrangelos, C., Campaniello, M., Dimasi, D., Bowen, J., . . . Hughes, P. (2018). Colonic migrating motor complexes are inhibited in acute tri-nitro benzene sulphonic acid colitis. PLoS ONE, 13(6), e0199394-1-e0199394-15. DOI Scopus11 WoS10 Europe PMC8
  2017	Das, S., & Smid, S. (2017). Identification of dibenzyl imidazolidine and triazole acetamide derivatives through virtual screening targeting amyloid beta aggregation and neurotoxicity in PC12 cells. European Journal of Medicinal Chemistry, 130, 354-364. DOI Scopus11 WoS11 Europe PMC3
  2017	Marsh, D., Das, S., Ridell, J., & Smid, S. (2017). Structure-activity relationships for flavone interactions with amyloid β reveal a novel anti-aggregatory and neuroprotective effect of 2′,3′,4′-trihydroxyflavone (2-D08). Bioorganic and Medicinal Chemistry, 25(14), 3827-3834. DOI Scopus27 WoS27 Europe PMC7
  2017	Campaniello, M. A., Mavrangelos, C., Eade, S., Harrington, A. M., Blackshaw, L. A., Brierley, S. M., . . . Hughes, P. A. (2017). Acute colitis chronically alters immune infiltration mechanisms and sensory neuro-immune interactions.. Brain, Behavior, and Immunity, 60, 319-332. DOI Scopus12 WoS11 Europe PMC6
  2016	Gibson, R., Coller, J., Wardill, H., Hutchinson, M., Smid, S., & Bowen, J. (2016). Chemotherapy-induced gut toxicity and pain: involvement of TLRs. Supportive Care in Cancer, 24(5), 2251-2258. DOI Scopus17 WoS16 Europe PMC6
  2016	Das, S., Stark, L., Musgrave, I., Pukala, T., & Smid, S. (2016). Bioactive polyphenol interactions with β amyloid: a comparison of binding modelling, effects on fibril and aggregate formation and neuroprotective capacity. Food & Function, 7(2), 1138-1146. DOI Scopus40 WoS38 Europe PMC14
  2016	Safdari, B., Sia, T., Wattchow, D., & Smid, S. (2016). Effects of pro-inflammatory cytokines, lipopolysaccharide and COX-2 mediators on human colonic neuromuscular function and epithelial permeability. Cytokine, 83, 231-238. DOI Scopus12 WoS10 Europe PMC6
  2016	Alghazwi, M., Kan, Y., Zhang, W., Gai, W., Garson, M., & Smid, S. (2016). Neuroprotective activities of natural products from marine macroalgae during 1999–2015. Journal of Applied Phycology, 28(6), 3599-3616. DOI Scopus32 WoS35
  2014	Janefjord, E., Maag, J., Harvey, B., & Smid, S. (2014). Cannabinoid effects on β amyloid fibril and aggregate formation, neuronal and microglial-activated neurotoxicity in vitro. Cellular and Molecular Neurobiology, 34(1), 31-42. DOI Scopus74 WoS68 Europe PMC40
  2014	Harvey, B., Sia, T., Wattchow, D., & Smid, S. (2014). Interleukin 17A evoked mucosal damage is attenuated by cannabidiol and anandamide in a human colonic explant model. Cytokine, 65(2), 236-244. DOI Scopus20 WoS18 Europe PMC11
  2013	Wong, D., Musgrave, I., Harvey, B., & Smid, S. (2013). Açaí (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against β-amyloid exposure in vitro. Neuroscience Letters, 556, 221-226. DOI Scopus34 WoS29 Europe PMC17
  2013	Harvey, B., Nicotra, L., Vu, M., & Smid, S. (2013). Cannabinoid CB2 receptor activation attenuates cytokine-evoked mucosal damage in a human colonic explant model without changing epithelial permeability. Cytokine (Online), 63(2), 209-217. DOI Scopus24 WoS22 Europe PMC19
  2013	Nicotra, L., Vu, M., Harvey, B., & Smid, S. (2013). Prostaglandin ethanolamides attenuate damage in a human explant colitis model. Prostaglandins & Other Lipid Mediators, 100(1), 22-29. DOI Scopus16 WoS16 Europe PMC10
  2012	Smid, S., Maag, J., & Musgrave, I. (2012). Dietary polyphenol-derived protection against neurotoxic β-amyloid protein: from molecular to clinical. Food & Function: linking the chemistry and physics of food with health and nutrition, 3(12), 1242-1250. DOI Scopus47 WoS44 Europe PMC19
  2012	Harvey, B., Ohlsson, K., Maag, J., Musgrave, I., & Smid, S. (2012). Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. Neurotoxicology, 33(1), 138-146. DOI Scopus55 WoS51 Europe PMC34
  2012	Harvey, B., & Smid, S. (2012). The gastrointestinal endocannabinoid system in health and inflammation. Current Topics in Pharmacology, 16(1), 107-118. Scopus1
  2011	Harvey, B., Musgrave, I., Ohlsson, K., Fransson, A., & Smid, S. (2011). The green tea polyphenol (−)-epigallocatechin-3-gallate inhibits amyloid-β evoked fibril formation and neuronal cell death in vitro. Food Chemistry, 129(4), 1729-1736. DOI Scopus37 WoS33 Europe PMC17
  2009	Smid, S. (2009). Role of prostaglandins and specific place in therapy of bimatoprost in the treatment of elevated intraocular pressure and ocular hypertension: A closer look at the agonist properties of bimatoprost and the prostamides. Clinical Ophthalmology (online), 3(1), 663-670. DOI Scopus14 Europe PMC7
  2009	Smid, S., & Svensson, K. (2009). Inhibition of cyclooxygenase-2 and EP₁ receptor antagonism reduces human colonic longitudinal muscle contractility in vitro. Prostaglandins & Other Lipid Mediators, 88(3-4), 117-121. DOI Scopus12 WoS11 Europe PMC8
  2008	Smid, S. (2008). Gastrointestinal endocannabinoid system: Multifaceted roles in the healthy and inflamed intestine. Clinical and Experimental Pharmacology and Physiology, 35(11), 1383-1387. DOI Scopus14 WoS12 Europe PMC8
  2007	Smid, S., Bjorklund, C., Svensson, K., Heigis, S., & Revesz, A. (2007). The endocannabinoids anandamide and 2-arachidonoylglycerol inhibit cholinergic contractility in the human colon. European Journal of Pharmacology, 575(1-3), 168-176. DOI Scopus24 WoS22 Europe PMC13
  2006	Hinds, N., Ullrich, K., & Smid, S. (2006). Cannabinoid 1 (CB1) receptors coupled to cholinergic motorneurones inhibit neurogenic circular muscle contractility in the human colon. British Journal of Pharmacology, 148(2), 191-199. DOI Scopus49 WoS46 Europe PMC40
  2005	Smith, A., & Smid, S. (2005). Impaired capsaicin and neurokinin-evoked colonic motility in inflammatory bowel disease. Journal of Gastroenterology and Hepatology, 20(5), 697-704. DOI Scopus28 WoS26 Europe PMC23
  2002	Lehmann, A., Blackshaw, L., Branden, L., Carlsson, A., Jensen, J., Nygren, E., & Smid, S. (2002). Cannabinoid receptor agonism inhibits transient lower esophageal sphincter relaxations and reflux in dogs. Gastroenterology, 123(4), 1129-1134. DOI Scopus87 WoS64 Europe PMC49
  2002	Lehmann, A., Blackshaw, L., Branden, L., Carlsson, A., Jensen, J., Nygren, E., & Smid, S. (2002). Cannabinoid receptor agonism inhibits transient lower esophageal sphincter relaxations and reflux in dogs (vol 123, pg 1129, 2002). GASTROENTEROLOGY, 123(6), 2162-2163.
  2002	Lehmann, A., Blackshaw, L. A., Branden, L., Carlsson, A., Jensen, J., Nygren, E., & Smid, S. D. (2002). Erratum: Cannabinoid receptor agonism inhibits transient lower esophageal sphincter relaxations and reflux in dogs (Gastroenterology (2002) 123 (1129-1134)). Gastroenterology, 123(6), 2162-2163. DOI
  2001	Smid, S., Young, R., Isaacs, N., & Blackshaw, L. (2001). GABABR expressed on vagal afferent neurones inhibit gastric mechanosensitivity in ferret proximal stomach. American Journal of Physiology - Gastrointestinal and Liver Physiology, 281(6), G1494-G1501. DOI Scopus62 WoS46 Europe PMC33
  2001	Smid, S. D., & Blackshaw, L. A. (2001). GABA(B) receptors inhibit vagal afferent mechanoreceptor responses to gastric distension.. GASTROENTEROLOGY, 120(5), A5-A6.
  2000	Smid, S. D., & Blackshaw, L. A. (2000). Ganglionic and neuroeffector transmission to the ferret lower esophageal sphincter in a novel in vitro oesophagogastric preparation.. GASTROENTEROLOGY, 118(4), A155. DOI
  2000	Blackshaw, L., Smid, S., Dent, J., & O'Donnell, T. (2000). GABAB receptor-mediated effects on vagal pathways to the lower oesophageal sphincter and heart. British Journal of Pharmacology, 130(2), 279-288. DOI Scopus43 WoS35 Europe PMC30
  2000	Staunton, E., Smid, S., Dent, J., & Blackshaw, L. (2000). Triggering of transient LES relaxations in ferrets: role of sympathetic pathways and effects of baclofen. American Journal of Physiology-Gastrointestinal and Liver Physiology, 279(1 42-1), G157-G162. DOI Scopus44 WoS33 Europe PMC26
  2000	Blackshaw, L., Page, A., Smid, S., Dent, J., & Lehmann, A. (2000). GABAB receptors - peripheral and central targets for controlling gastroesophageal reflux. Current Opinion in Central & Peripheral Nervous System Investigational Drugs, 2(3), 333-343. Scopus7
  2000	Smid, S., & Blackshaw, L. (2000). Neuromuscular function of the human lower oesophageal sphincter in reflux disease and Barrett's oesophagus. Gut, 46(6), 756-761. DOI Scopus19 WoS16 Europe PMC10
  2000	Smid, S., & Blackshaw, L. (2000). Vagal neurotransmission to the ferret lower oesophageal sphincter: inhibition via GABAB receptors. British Journal of Pharmacology, 131(3), 624-630. DOI Scopus25 WoS21 Europe PMC16
  2000	Smid, S., & Blackshaw, L. (2000). Vagal ganglionic and nonadrenergic noncholinergic neurotransmission to the ferret lower oesophageal sphincter. Autonomic Neuroscience-Basic & Clinical, 86(1-2), 30-36. DOI Scopus6 WoS5 Europe PMC5
  1998	Smid, S. D., Page, A. J., O'Donnell, T., Langman, J., Rowland, R., & Blackshaw, L. A. (1998). Oesophagitis-induced changes in capsaicin-sensitive tachykininergic pathways in the ferret lower oesophageal sphincter. Neurogastroenterology and Motility, 10(5), 403-411. DOI Scopus15 WoS11 Europe PMC11
  1998	Smid, S. D., Lynn, P. A., Templeman, R., & Blackshaw, L. A. (1998). Activation of non-adrenergic non-cholinergic inhibitory pathways by endogenous and exogenous tachykinins in the ferret lower oesophageal sphincter. Neurogastroenterology and Motility, 10(2), 149-156. DOI Scopus16 WoS15 Europe PMC10
  1995	Smid, S., Frewin, D., Wyartt, C., & Head, R. (1995). Functional tolerance to a-adrenergic receptor blockade in the spontaneously hypertensive rat highlights the multi-functional role of vascular angiotensin II in the development of hypertension. Journal of Vascular Research, 32(4), 247-253. DOI Scopus4 WoS4 Europe PMC2
  1993	Jonsson, J., Smid, S., Frewin, D., & Head, R. (1993). Angiotensin II-mediated facilitation of sympathetic neurotransmission in the spontaneously hypertensive rat is not associated with neuronal uptake of the peptide. Journal of Cardiovascular Pharmacology, 22(5), 750-753. DOI Scopus16 WoS14 Europe PMC10

• Book Chapters

  Year	Citation
  2014	Das, S., & Smid, S. (2014). The Antiaggregative, Antiamyloid Properties of Bioactive Polyphenols in the Treatment of Alzheimer's Disease. In R. Watson (Ed.), Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease: Prevention and Therapy (pp. 73-76). United Kingdom: Academic Press. DOI Scopus1
  2013	Smid, S., & Musgrave, I. (2013). Dietary polyphenols as inhibitors of Β-amyloid-evoked neurotoxicity: implications for the treatment of Alzheimer's disease. In J. Sun, K. Prasad, A. Ismail, B. Yang, X. You, & L. Li (Eds.), Polyphenols: Chemistry, Dietary Sources and Health Benefits (1 ed., pp. 521-538). United States: Nova Science Publishers.
  2009	Smid, S. (2009). Neuronal mechanosensitivity in the gastrointestinal tract. In A. Kamkin, I. Kiseleva, N. Tavernarakis, & P. Persson (Eds.), Mechanosensitivity of the nervous system (pp. 87-106). Russia: Springer. DOI

• Conference Papers

  Year	Citation
  2015	Smid, S., Das, S., Musgrave, I., & Pukala, T. (2015). Bioactive polyphenol interactions with beta amyloid: a comparison of binding, fibril inhibition and neuroprotection. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 363-364). Cairns, AUSTRALIA: WILEY-BLACKWELL.

• Conference Items

  Year	Citation
  2016	Campaniello, M., Mavrangelos, C., Dimasi, D., Hofma, B., Eade, S., Smid, S., . . . Hughes, P. A. (2016). Innate cell infiltration during acute TNBS colitis alters enteric nerve activity. Poster session presented at the meeting of Gastroenterology. San Diego, CA: Elsevier Inc.. DOI
  2011	Smid, S., Salem, A., & Musgrave, I. (2011). Blended learning approaches to practical teaching in pharmacology: the best of both worlds?. Poster session presented at the meeting of Transformation. Adelaide, Australia.
  2010	Salem, A., Smid, S., Musgrave, I., & Carrington, A. (2010). Development and integration of web-based pharmacology e-resources designed to provide immediate feedback and interactive help. Poster session presented at the meeting of The Education Research Group of Adelaid. Adelaide, Australia: The University of Adelaide.

Teaching and Course Coordination

• Current Higher Degree by Research Supervision (University of Adelaide)

  Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
  2022	Co-Supervisor	Structure-Based Discovery of Multi-Target Anti-Aggregatory Drugs in Alzheimer’s Disease	Doctor of Philosophy	Doctorate	Full Time	Mr Zohaib Raza
  2022	Principal Supervisor	The bioprotective properties of cannabis phytochemicals on mammalian cells	Doctor of Philosophy	Doctorate	Full Time	Mr Luke Thomas Wooley
  2021	Principal Supervisor	Bioactivity characterization of novel cannabis phytochemicals	Master of Philosophy (Medical Science)	Master	Full Time	Mr John Laws III
  2019	Principal Supervisor	Neuroprotective Bioactivity of Marine and Plant Based Polyphenols	Doctor of Philosophy	Doctorate	Full Time	Mr Srijan Shrestha
  2017	Principal Supervisor	Bioactivity of Phytochemicals in Neurodegenerative and Inflammatory Diseases	Doctor of Philosophy	Doctorate	Full Time	Mr Dylan Thomas Marsh

• Past Higher Degree by Research Supervision (University of Adelaide)

  Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
  2016 - 2020	Co-Supervisor	Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease	Doctor of Philosophy	Doctorate	Full Time	Miss Nicole Dmochowska
  2015 - 2018	Principal Supervisor	Small molecular inhibitors of Amyloid beta and alpha Synuclein amyloidogenic aggregation, toxicity and in silico design of amyloid-binding ligands	Doctor of Philosophy	Doctorate	Full Time	Mrs Sukanya Das
  2010 - 2014	Principal Supervisor	The Effect of Cannabinoids on Cytokine Evoked Human Colonic Mucosal Damage and Caco-2 Epithelial Permeability	Doctor of Philosophy	Doctorate	Full Time	Mr Benjamin Harvey

• Board Memberships

  Date	Role	Board name	Institution name	Country
  2015 - ongoing	Advisory Board Member	Scientific Advisory Board	LeafCann Pty Ltd	Australia

• Committee Memberships

  Date	Role	Committee	Institution	Country
  2009 - ongoing	Member	Scientific Organising Committee, Annual National Symposia: Urogenital and Gastrointestinal Research

• Memberships

  Date	Role	Membership	Country
  2017 - ongoing	Member	Australia New Zealand Marine Biotechnology Society	Australia
  2016 - ongoing	Member	International Cannabinoid Research Society
  2014 - ongoing	Member	International Society for Neurochemistry
  2014 - ongoing		International Society for Neurochemistry
  2006 - ongoing		International Cannabinoid Research Society
  1991 - ongoing	Member	Australasian Society for Clinical and Experimental Pharmacology and Toxicology
  1991 - ongoing		Australasian Society of Clinical and Experimental Pharmacology and Toxicology (ASCEPT).

• Consulting/Advisories

  Date	Institution	Department	Organisation Type	Country
  2015 - ongoing	LeafCann Australia Pty Ltd

• Editorial Boards

  Date	Role	Editorial Board Name	Institution	Country
  2013 - ongoing	Board Member	Clinical and Experimental Physiology and Pharmacology Journal
  2012 - ongoing	Editor	CEPP journal

• Industry Partnerships

  Date	Engagement Type	Partner Name
  2016 - ongoing	Consultant	CSIRO Materials Division

• Position: Senior Lecturer
• Phone: 83135287
• Email: scott.smid@adelaide.edu.au
• Fax: 82240685
• Campus: North Terrace
• Building: Helen Mayo North, floor 3
• Org Unit: Medical Sciences