Scott Smid

Dr Scott Smid

Senior Lecturer

School of Biomedicine

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Dr Scott Smid is a pharmacologist specializing in drug discovery and development research both in industry and academia. He maintains a strong research interest in experimental therapeutics applied towards novel treatments for gastrointestinal and neurodegenerative diseases. This includes investigating the biological actions of phytocannabinoids, synthetic cannabinoids and endocannabinoids in areas as diverse as gut function, inflammation and neurodegeneration. Current interests include novel ligand development for binding and inhibiting pathological aggregating proteins such as beta-amyloid and alpha-synuclein, which are associated with Alzheimer's and Parkinson's disease.

Current projects for Honours, Masters, M.Phil or PhD candidates include:

1. Identifying novel cannabis phytochemicals with neuroprotective properties. This includes using neural stem cells and other neuronal cell populations to model neurotoxicity to dementia associated misfolding proteins such as amyloid beta and alpha-synuclein, related to Alzheimer's and Parkinson's disease. We recently identified a novel cannabis flavonoid with neuroprotective activity that could be used as a nutritional or nutraceutical supplement in ageing. We have also identified select terpenes found in cannabis that also share these neuroportective properties.

2. Identifying novel cannabis phytochemicals with gastroprotective properties. This project looks at identifying novel cannabis phytochemicals with mucoprotective properties in the gut lining, related to inflammatory and other injurious conditions such as Crohn's disease and chemotherapy-induced mucositis. Co-investigators at SAHMRI and I are currently funded by MRFF to investigate benefits of medicinal cannabis in chemotherapy-induced intestinal damage in a clinical trial together with a medical cannabis industry partner, LeafCann.

3. Understanding cannabis-herb and cannabis-drug interactions. This is a molecular toxicology project aimed at understanding how cannabis and its components can influence metabolic pathways that may affect conventional medications or complementary medicines. With increasing medicinal cannabis use in Australia this has implications for dosing and individualised medicine.

4. Identifying novel cannabis phytochemicals with antibiotic properties. The non-psychotropic component of cannabis, cannabidiol (CBD) has recently been identified as having potential antibiotic properties. Derivatives of CBD and other novel phytocannabinoids may be obtained to test this in a collaboration with Dr Katharina Richter at BHI with scholarships available. See for more information.

5. Identifying and characterising novel marine-derived polyphenols with gastro- and neuro-protective properties. This is a collaboration with the Centre for Marine Bioproducts Development at Flinders University. For example, we have identified phlorotannins from brown macroalgae (seaweed) found along coastal regions in South Australia that have neuroprotective and mucoprotective bioactivity.

  • Appointments

    Date Position Institution name
    2015 - ongoing Visiting Fellow University of Western Australia, Perth
    2012 - ongoing Deputy Head University of Adelaide, Adelaide
    2006 - ongoing Senior Lecturer University of Adelaide, Adelaide
  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2012 Award Faculty International Conference Award (FICA)
  • Education

    Date Institution name Country Title
    1991 - 1994 University of Adelaide, Adelaide Australia Doctor of Philosophy
    1990 University of Adelaide, Adelaide Australia Honours Degree of Bachelor of Science (Class 1 Honours)
    1979 - 1989 University of Adelaide, Adelaide Australia Bachelor of Science
  • Research Interests

Grants and Funding
Research Support and Scholarship
2022 Principal Investigator. Marine-derived bioactives and nutraceuticals: Sustainable use of marine products for health and wellbeing. AC21 Special Project Funding $USD 15,000
2021 Co-Investigator. Exploring the use of personalised CBD/THC dosing to prevent common and impactful symptoms of treatment in advanced cancer. The CANnabinoids for CANcer Therapy (CANCAN) Clinical Trial: Medical Research Futures Fund, Department of Health, Australian Goverment. $AUD $1.5M


Principal Investigator. Australia Japan Foundation Award, Dept Foreign Affairs and Trade. Enabling technologies in Personalised and Precision Medicine.

$AUD 38,600

2018 JSPS Invitational Fellowship, Nagoya University. Development of Super-efficient Screening Technologies for Neural Cell Regulatory Products.



2018 Principal Investigator. Faculty Research Infrastructure Award. The University of Adelaide. AUD $17,000
2017-18 Principal Investigator. Faculty Research Development Award (with Prof Kato, Nagoya University and Dr Ian Musgrave). Novel neuroprotective agents targeting beta amyloid. The University of Adelaide. AUD $15,500
2013-15 Co-Investigator (with Ian Musgrave, Louise O’Keefe and Tara Pukala). 'Structure function relationships of anti-amyloid drugs: verification in an in-vivo model.' lnterdisciplinary Research Fund Grant, The University of Adelaide. AUD $21,000
2011-13 Principal Investigator. (Associate Investigator: Dr Rachel Gibson). Validation of an ex vivo human colonic mucosal explant colitis model. MAWA Trust Research Grant. AUD $28,122
2010-12 Principal Investigator Broad Medical Research Program, United States (IBD-0268R). Functional Expression of the Endocannabinoid System in Inflammatory Bowel Disease. USD $130,000
Teaching and Course Coordination
2006-present The University of Adelaide: Course Coordinator - PHARM 3102 Drug Discovery & Development; HLTH SC 2100 Fundamentals of Human Nutrition. Courses taught: Pharmacology 2100/2200 (Level 2 B.Hlth.Sci, B. Pharm. Eng.). Pharmacology for Nursing (Level 1&2, Bachelor of Nursing). PHARM 3101, 3102, 3103, HLTH SC 2100, 2103, 2104, 3100. Higher Degree by Research: Discipline Coordinator
  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2022 Co-Supervisor Structure-Based Discovery of Multi-Target Anti-Aggregatory Drugs in Alzheimer’s Disease Doctor of Philosophy Doctorate Full Time Mr Zohaib Raza
    2022 Principal Supervisor The bioprotective properties of cannabis phytochemicals on mammalian cells Doctor of Philosophy Doctorate Full Time Mr Luke Thomas Wooley
    2021 Principal Supervisor Bioactivity characterization of novel cannabis phytochemicals Master of Philosophy (Medical Science) Master Full Time Mr John Laws III
    2019 Principal Supervisor Neuroprotective Bioactivity of Marine and Plant Based Polyphenols Doctor of Philosophy Doctorate Full Time Mr Srijan Shrestha
    2017 Principal Supervisor Bioactivity of Phytochemicals in Neurodegenerative and Inflammatory Diseases Doctor of Philosophy Doctorate Full Time Mr Dylan Thomas Marsh
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2016 - 2020 Co-Supervisor Visualising Intestinal Inflammation and Fibrosis using Zirconium-89 Labelled Antibodies in a Preclinical Model of Inflammatory Bowel Disease Doctor of Philosophy Doctorate Full Time Miss Nicole Dmochowska
    2015 - 2018 Principal Supervisor Small molecular inhibitors of Amyloid beta and alpha Synuclein amyloidogenic aggregation, toxicity and in silico design of amyloid-binding ligands Doctor of Philosophy Doctorate Full Time Mrs Sukanya Das
    2010 - 2014 Principal Supervisor The Effect of Cannabinoids on Cytokine Evoked Human Colonic Mucosal Damage and Caco-2 Epithelial Permeability Doctor of Philosophy Doctorate Full Time Mr Benjamin Harvey
  • Position: Senior Lecturer
  • Phone: 83135287
  • Email:
  • Fax: 82240685
  • Campus: North Terrace
  • Building: Helen Mayo North, floor 3
  • Org Unit: Medical Sciences

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