Dr Scott Smid

Scott Smid
Senior Lecturer
Adelaide Medical School
Faculty of Health and Medical Sciences

Dr Scott Smid is a pharmacologist specializing in drug discovery and development research both in industry and academia. He maintains a strong research interest in experimental therapeutics applied towards novel treatments for gastrointestinal and neurodegenerative diseases. This includes investigating the biological actions of phytocannabinoids, synthetic cannabinoids and endocannabinoids in areas as diverse as gut function, inflammation and neurodegeneration. Current interests include novel ligand development for binding and inhibiting pathological aggregating proteins such as beta-amyloid and alpha-synuclein, which are associated with Alzheimer's and Parkinson's disease.

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Dr Scott Smid

Dr Scott Smid is a pharmacologist specializing in drug discovery and development research both in industry and academia. He maintains a strong research interest in experimental therapeutics applied towards novel treatments for gastrointestinal and neurodegenerative diseases. This includes investigating the biological actions of phytocannabinoids, synthetic cannabinoids and endocannabinoids in areas as diverse as gut function, inflammation and neurodegeneration. Current interests include novel ligand development for binding and inhibiting pathological aggregating proteins such as beta-amyloid and alpha-synuclein, which are associated with Alzheimer's and Parkinson's disease.

Dr Scott Smid is a pharmacologist specializing in drug discovery and development research both in industry and academia. He maintains a strong research interest in experimental therapeutics applied towards novel treatments for gastrointestinal and neurodegenerative diseases. This includes investigating the biological actions of phytocannabinoids, synthetic cannabinoids and endocannabinoids in areas as diverse as gut function, inflammation and neurodegeneration. Current interests include novel ligand development for binding and inhibiting pathological aggregating proteins such as beta-amyloid and alpha-synuclein, which are associated with Alzheimer's and Parkinson's disease.

Appointments

Date Position Institution name
2015 Visiting Fellow University of Western Australia, Perth
2012 Deputy Head University of Adelaide, Adelaide
2010 - 2014 Postgraduate Coordinator University of Adelaide, Adelaide
2006 Senior Lecturer University of Adelaide, Adelaide

Awards and Achievements

Date Type Title Institution Name Amount
2012 Award Faculty International Conference Award (FICA)

Education

Date Institution name Country Title
1991 - 1994 University of Adelaide, Adelaide Australia Doctor of Philosophy
1990 University of Adelaide, Adelaide Australia Honours Degree of Bachelor of Science (Class 1 Honours)
1979 - 1989 University of Adelaide, Adelaide Australia Bachelor of Science

Research Interests

Neuroscience, Behaviour and Brain Health, Immunology and Infection, Innovative Therapeutics

Journals

Year Citation
2017 Campaniello, M., Mavrangelos, C., Eade, S., Harrington, A., Blackshaw, L., Brierley, S. ... Hughes, P. (2017). Acute colitis chronically alters immune infiltration mechanisms and sensory neuro-immune interactions.. Brain, Behavior, and Immunity, 60, 319-332.
10.1016/j.bbi.2016.11.015
2017 Das, S. & Smid, S. (2017). Identification of dibenzyl imidazolidine and triazole acetamide derivatives through virtual screening targeting amyloid beta aggregation and neurotoxicity in PC12 cells. European Journal of Medicinal Chemistry, 130, 354-364.
10.1016/j.ejmech.2017.02.057
2017 Marsh, D., Das, S., Ridell, J. & Smid, S. (2017). Structure-activity relationships for flavone interactions with amyloid β reveal a novel anti-aggregatory and neuroprotective effect of 2′,3′,4′-trihydroxyflavone (2-D08). Bioorganic and Medicinal Chemistry, 25, 14, 3827-3834.
10.1016/j.bmc.2017.05.041
2016 Safdari, B., Sia, T., Wattchow, D. & Smid, S. (2016). Effects of pro-inflammatory cytokines, lipopolysaccharide and COX-2 mediators on human colonic neuromuscular function and epithelial permeability. Cytokine, 83, 231-238.
10.1016/j.cyto.2016.04.017
2016 Gibson, R., Coller, J., Wardill, H., Hutchinson, M., Smid, S. & Bowen, J. (2016). Chemotherapy-induced gut toxicity and pain: involvement of TLRs. Supportive Care in Cancer, 24, 5, 2251-2258.
10.1007/s00520-015-3020-2
2016 Alghazwi, M., Kan, Y., Zhang, W., Gai, W., Garson, M. & Smid, S. (2016). Neuroprotective activities of natural products from marine macroalgae during 1999–2015. Journal of Applied Phycology, 28, 6, 3599-3616.
10.1007/s10811-016-0908-2
2016 Das, S., Stark, L., Musgrave, I., Pukala, T. & Smid, S. (2016). Bioactive polyphenol interactions with β amyloid: a comparison of binding modelling, effects on fibril and aggregate formation and neuroprotective capacity. Food & Function, 7, 2, 1138-1146.
10.1039/c5fo01281c
2014 Janefjord, E., Maag, J., Harvey, B. & Smid, S. (2014). Cannabinoid effects on β amyloid fibril and aggregate formation, neuronal and microglial-activated neurotoxicity in vitro. Cellular and Molecular Neurobiology, 34, 1, 31-42.
10.1007/s10571-013-9984-x
2014 Harvey, B., Sia, T., Wattchow, D. & Smid, S. (2014). Interleukin 17A evoked mucosal damage is attenuated by cannabidiol and anandamide in a human colonic explant model. Cytokine, 65, 2, 236-244.
10.1016/j.cyto.2013.10.006
2013 Wong, D., Musgrave, I., Harvey, B. & Smid, S. (2013). Açaí (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against β-amyloid exposure in vitro. Neuroscience Letters, 556, 221-226.
10.1016/j.neulet.2013.10.027
2013 Harvey, B., Nicotra, L., Vu, M. & Smid, S. (2013). Cannabinoid CB2 receptor activation attenuates cytokine-evoked mucosal damage in a human colonic explant model without changing epithelial permeability. Cytokine (Online), 63, 2, 209-217.
10.1016/j.cyto.2013.04.032
2013 Nicotra, L., Vu, M., Harvey, B. & Smid, S. (2013). Prostaglandin ethanolamides attenuate damage in a human explant colitis model. Prostaglandins & Other Lipid Mediators, 100, 1, 22-29.
10.1016/j.prostaglandins.2013.01.003
2012 Smid, S., Maag, J. & Musgrave, I. (2012). Dietary polyphenol-derived protection against neurotoxic β-amyloid protein: from molecular to clinical. Food & Function: linking the chemistry and physics of food with health and nutrition, 3, 12, 1242-1250.
10.1039/c2fo30075c
2012 Harvey, B., Ohlsson, K., Maag, J., Musgrave, I. & Smid, S. (2012). Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. Neurotoxicology, 33, 1, 138-146.
10.1016/j.neuro.2011.12.015
2012 Harvey, B. & Smid, S. (2012). The gastrointestinal endocannabinoid system in health and inflammation. Current Topics in Pharmacology, 16, 1, 107-118.
2011 Harvey, B., Musgrave, I., Ohlsson, K., Fransson, A. & Smid, S. (2011). The green tea polyphenol (−)-epigallocatechin-3-gallate inhibits amyloid-β evoked fibril formation and neuronal cell death in vitro. Food Chemistry, 129, 4, 1729-1736.
10.1016/j.foodchem.2011.06.040
2009 Smid, S. (2009). Role of prostaglandins and specific place in therapy of bimatoprost in the treatment of elevated intraocular pressure and ocular hypertension: A closer look at the agonist properties of bimatoprost and the prostamides. Clinical Ophthalmology (online), 3, 1, 663-670.
10.2147/opth.s6337
2009 Smid, S. & Svensson, K. (2009). Inhibition of cyclooxygenase-2 and EP₁ receptor antagonism reduces human colonic longitudinal muscle contractility in vitro. Prostaglandins & Other Lipid Mediators, 88, 3-4, 117-121.
10.1016/j.prostaglandins.2008.12.004
2008 Smid, S. (2008). Gastrointestinal endocannabinoid system: Multifaceted roles in the healthy and inflamed intestine. Clinical and Experimental Pharmacology and Physiology, 35, 11, 1383-1387.
10.1111/j.1440-1681.2008.05016.x
2007 Smid, S., Bjorklund, C., Svensson, K., Heigis, S. & Revesz, A. (2007). The endocannabinoids anandamide and 2-arachidonoylglycerol inhibit cholinergic contractility in the human colon. European Journal of Pharmacology, 575, 1-3, 168-176.
10.1016/j.ejphar.2007.07.036
2006 Hinds, N., Ullrich, K. & Smid, S. (2006). Cannabinoid 1 (CB1) receptors coupled to cholinergic motorneurones inhibit neurogenic circular muscle contractility in the human colon. British Journal of Pharmacology, 148, 2, 191-199.
10.1038/sj.bjp.0706710
2005 Smith, A. & Smid, S. (2005). Impaired capsaicin and neurokinin-evoked colonic motility in inflammatory bowel disease. Journal of Gastroenterology and Hepatology, 20, 5, 697-704.
10.1111/j.1440-1746.2005.03759.x
2002 Lehmann, A., Blackshaw, L., Branden, L., Carlsson, A., Jensen, J., Nygren, E. & Smid, S. (2002). Cannabinoid receptor agonism inhibits transient lower esophageal sphincter relaxations and reflux in dogs. Gastroenterology, 123, 4, 1129-1134.
10.1053/gast.2002.36025
2001 Smid, S. & Blackshaw, L. (2001). GABA(B) receptors inhibit vagal afferent mechanoreceptor responses to gastric distension.. GASTROENTEROLOGY, 120, 5, A5-A6.
2001 Smid, S., Young, R., Isaacs, N. & Blackshaw, L. (2001). GABABR expressed on vagal afferent neurones inhibit gastric mechanosensitivity in ferret proximal stomach. American Journal of Physiology - Gastrointestinal and Liver Physiology, 281, 6, G1494-G1501.
2000 Smid, S. & Blackshaw, L. (2000). Vagal neurotransmission to the ferret lower oesophageal sphincter: inhibition via GABAB receptors. British Journal of Pharmacology, 131, 3, 624-630.
10.1038/sj.bjp.0703602
2000 Blackshaw, L., Page, A., Smid, S., Dent, J. & Lehmann, A. (2000). GABAB receptors - peripheral and central targets for controlling gastroesophageal reflux. Current Opinion in Central & Peripheral Nervous System Investigational Drugs, 2, 3, 333-343.
2000 Smid, S. & Blackshaw, L. (2000). Neuromuscular function of the human lower oesophageal sphincter in reflux disease and Barrett's oesophagus. Gut, 46, 6, 756-761.
10.1136/gut.46.6.756
2000 Staunton, E., Smid, S., Dent, J. & Blackshaw, L. (2000). Triggering of transient LES relaxations in ferrets: role of sympathetic pathways and effects of baclofen. American Journal of Physiology-Gastrointestinal and Liver Physiology, 279, 1 42-1, G157-G162.
2000 Smid, S. & Blackshaw, L. (2000). Vagal ganglionic and nonadrenergic noncholinergic neurotransmission to the ferret lower oesophageal sphincter. Autonomic Neuroscience-Basic & Clinical, 86, 1-2, 30-36.
10.1016/S1566-0702(00)00210-1
2000 Blackshaw, L., Smid, S., Dent, J. & O'Donnell, T. (2000). GABAB receptor-mediated effects on vagal pathways to the lower oesophageal sphincter and heart. British Journal of Pharmacology, 130, 2, 279-288.
10.1038/sj.bjp.0703244
1995 Smid, S., Frewin, D., Wyartt, C. & Head, R. (1995). Functional tolerance to a-adrenergic receptor blockade in the spontaneously hypertensive rat highlights the multi-functional role of vascular angiotensin II in the development of hypertension. Journal of Vascular Research, 32, 4, 247-253.
10.1159/000159099

Book Chapters

Year Citation
2014 Das, S. & Smid, S. D. (2014). The Antiaggregative, Antiamyloid Properties of Bioactive Polyphenols in the Treatment of Alzheimer's Disease. In R. R. Watson (Ed.), Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease: Prevention and Therapy (pp. 73-76). United Kingdom: Academic Press.
10.1016/B978-0-12-411462-3.00008-4
2013 Smid, S. & Musgrave, I. (2013). Dietary polyphenols as inhibitors of Β-amyloid-evoked neurotoxicity: implications for the treatment of Alzheimer's disease. In J. Sun, K. N. Prasad, A. Ismail, B. Yang, X. You & L. Li (Eds.), Polyphenols: Chemistry, Dietary Sources and Health Benefits (pp. 521-538). United States: Nova Science Publishers.
2009 Smid, S. (2009). Neuronal mechanosensitivity in the gastrointestinal tract. In A. Kamkin, I. Kiseleva, N. Tavernarakis & P. Persson (Eds.), Mechanosensitivity of the nervous system (pp. 87-106). Russia: Springer.
10.1007/978-1-4020-8716-5_5

Conference Items

Year Citation
2015 Smid, S., Das, S., Musgrave, I. & Pukala, T. (2015). Bioactive polyphenol interactions with beta amyloid: a comparison of binding, fibril inhibition and neuroprotection. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society. Cairns, AUSTRALIA.
2011 Smid, S., Salem, A. & Musgrave, I. (2011). Blended learning approaches to practical teaching in pharmacology: the best of both worlds?. ERGA Conference. Adelaide, Australia.
2010 Salem, A., Smid, S., Musgrave, I. & Carrington, A. (2010). Development and integration of web-based pharmacology e-resources designed to provide immediate feedback and interactive help. ERGA Conference. Adelaide, Australia.
Grants and Funding
Development Initiatives and Funding: Teaching and Internationalisation
2015 Priority Partner Funding Grant, Nagoya University. Linkage facilitation. $3000
2014-15 BEACON Set-Up Grants for New Study Tours. Establishing a program of study abroad electives for Bachelor of Health Sciences students to Sweden. $5,000
2013 International Office, University of Gothenburg. G. Tobin, M Winder, P. Aronsson and S Smid. "International mobility: Extended bilateral cooperation with the University of Adelaide". 30,000 SEK
2011-12

Seminar: Blended learning approaches to practical teaching in pharmacology: the best of both worlds? 6th ERGA Conference, University of Adelaide, Sep. 28-30.

Seminar: Development of discipline specific teaching tools based on LabTutor to improve practicum delivery. ASCEPT Education Workshop, Perth, Dec.4. 2011.

Seminar: e-learning in an online environment in pharmacokinetics. e-learning forum, School of Medical Sciences, Sep. 3, 2012.

 

 

Research Support and Scholarship
2013-15 Co-Investigator (with Ian Musgrave, Louise O’Keefe and Tara Pukala). 'Structure function relationships of anti-amyloid drugs: verification in an in-vivo model.' lnterdisciplinary Research Fund Grant, The University of Adelaide. AUD $21,000.
2011-13 Principal Investigator. (Associate Investigator: Dr Rachel Gibson). Validation of an ex vivo human colonic mucosal explant colitis model. MAWA Trust Research Grant. AUD $28,122.
2013 Principal Investigator (with Drs A. Humpage and L. Fabbro). Characterisation of cyanobacterial Limnothrix muco- and neurotoxicity. School of Medical Sciences SRE project funding. AUD $3000.
2010-12 Principal Investigator Broad Medical Research Program, (IBD-0268R). Functional Expression of the Endocannabinoid System in Inflammatory Bowel Disease. USD $130,000
Teaching and Course Coordination
2006-present The University of Adelaide: Course Coordinator - Pharmacology 3010/3011 (Level 3 B.Sc., B.Hlth.Sci). Pharmacology 2100/2200 (Level 2 B.Hlth.Sci, B. Pharm. Eng.). Pharmacology for Nursing (Level 1&2, Bachelor of Nursing). Higher Degree by Research: Discipline Coordinator (2007-2014).
Supervision
Research Supervision – postgraduate
2013- Sukanya Das. Computational predictive analysis of β amyloid aggregation inhibitors as novel treatments for Alzheimer’s disease. PhD candidate. FHS Divisional Scholar.
2010-2014 Benjamin Harvey. Role of Endocannabinoid System and Prostamides in the Development of Colitis and Inflammatory Bowel Disease. PhD conferred July 31, 2014. Awarded Dean’s Commendation for Doctoral Thesis Excellence. APA Scholar.
2015- Adjunct co-supervisor, Mr Mousa Alghazwi. PhD candidate, CMBD and Department of Medical Biotechnology, Flinders University. Characterization of neuroprotective compounds in from marine sponges and macroalgae in South Australia.
2016- Co-supervisor, Ms Nicole Dmochowska, PhD candidate. Characterising the immune profile in Inflammatory Bowel Disease using novel in-vivo imaging technologies. APA and Southcott Memorial Scholarship holder in nuclear medicine.
2016- Co-supervisor, Mr Chen Gao. PhD candidate. Development of a novel transgenic drosophila model for studying bioactive based neuroprotection against Alzheimer’s disease. FHS Divisional Scholar. 3
2017

Dylan Marsh (PhD). Enteric neurons as a model system to investigate protein amyloidosis and drug interventions

2017 Dylan Whan (PhD) Marine Bioproducts drug discovery related to inflammation and neuroprotection

 

Research – Other
2016 Contract research, CSIRO Materials, Parkville, Victoria. Bioavailability assays of small molecule herbal formulation extracts in Caco-2 monolayers
2010-11 Ms Megan Vu, Research Officer (contract employee on IBD-0268R)
2004- Research thesis students, MSc (Pharm): Gothenburg (16), Uppsala (1). Vacation scholars (3)

 

Honours Supervision (Primary)
2016 Mr Dylan Whan, Mr Dylan Marsh (Norman Weir Scholarship for Parkinson’s Disease research), Ms Samantha Dama. Neuroprotection and medicinal chemistry projects.
2015 Ms Nicole Dmochowska (Class I), Mr Benjamin Hofma (Class I), Mr Samuel Eade (Class IIA). Various GI projects – colitis, cytokine/ motility and barrier function.
2013-14 Ms Bavani Gunasegaran (International). Cyclotherapy project. Class IIA
2012 Ms Baz Safdari (Class I). Cytokine effects on GI function. MAWA Honours Scholarship award, $10,000. Ms Daphne Wong (Class IIA.); β-amyloid and bioactive project.
2009 Ms Lauren Nicotra. Cannabinoids and colitis project (Class I). Mr Benjamin Harvey. (Class I). Natural products and neuroprotection project.
2004 Nick Hinds (CQU): Class I. Poster of merit AGW 2004 (Brisbane)
2001 Ms Alicia Smith (Class IIA). Dept of Physiology (affiliate), University of Adelaide

Memberships

Date Role Membership Country
2017 - ongoing Member Australia New Zealand Marine Biotechnology Society Australia
2016 - ongoing Member International Cannabinoid Research Society
2014 - ongoing Member International Society for Neurochemistry
2014 - ongoing International Society for Neurochemistry
2006 - ongoing International Cannabinoid Research Society
1991 - ongoing Member Australasian Society for Clinical and Experimental Pharmacology and Toxicology
1991 - ongoing Australasian Society of Clinical and Experimental Pharmacology and Toxicology (ASCEPT).

Committee Memberships

Date Role Committee Institution Country
2009 - ongoing Member Scientific Organising Committee, Annual National Symposia: Urogenital and Gastrointestinal Research

Board Memberships

Date Role Board name Institution name Country
2015 - ongoing Advisory Board Member Scientific Advisory Board LeafCann Pty Ltd Australia

Editorial Boards

Date Role Editorial Board Name Country
2013 - ongoing Board Member Clinical and Experimental Physiology and Pharmacology Journal
2012 - ongoing Editor CEPP journal

Industry Partnerships

Date Engagement Type Partner Name
2016 - ongoing Consultant CSIRO Materials Division

Consulting/Advisories

Date Institution Department Organisation Type Country
2015 - ongoing LeafCann Australia Pty Ltd
Position
Senior Lecturer
Phone
83135287
Fax
8224 0685
Campus
North Terrace
Building
Medical School North
Room Number
5 31
Org Unit
Medical Sciences

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