Dr Scott Penfold

Scott Penfold
Lecturer
School of Physical Sciences
Faculty of Sciences

I am a Certified Medical Physics Specialist within the field of Radiation Oncology. I completed my undergraduate studies at the University of Wollongong (UoW) and was awarded the University Medal in the Faculty of Engineering in 2006. I subsequently went on to complete my PhD in a joint project with UoW and Loma Linda University Medical Center in California.

In 2010, during the last year of my PhD, I began clinical medical physics training at the Royal Adelaide Hospital (RAH). In 2013 I sat my final certification exam and joined the ACPSEM register of certified medical physics specialists.

In September 2013, I joined the University of Adelaide (UoA) Department of Physics as a half-time academic, while also retaining half-time employment at the RAH. I am currently working as the postgraduate co-ordinator for Medical Physics at UoA. My roles include undergraduate practical demonstration and lecturing, and postgraduate lecturing and research supervision.

My research interests predominantly lie in proton therapy and quantitative imaging for image guided radiotherapy.

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Dr Scott Penfold

I am a Certified Medical Physics Specialist within the field of Radiation Oncology. I completed my undergraduate studies at the University of Wollongong (UoW) and was awarded the University Medal in the Faculty of Engineering in 2006. I subsequently went on to complete my PhD in a joint project with UoW and Loma Linda University Medical Center in California.

In 2010, during the last year of my PhD, I began clinical medical physics training at the Royal Adelaide Hospital (RAH). In 2013 I sat my final certification exam and joined the ACPSEM register of certified medical physics specialists.

In September 2013, I joined the University of Adelaide (UoA) Department of Physics as a half-time academic, while also retaining half-time employment at the RAH. I am currently working as the postgraduate co-ordinator for Medical Physics at UoA. My roles include undergraduate practical demonstration and lecturing, and postgraduate lecturing and research supervision.

My research interests predominantly lie in proton therapy and quantitative imaging for image guided radiotherapy.

Eligible to supervise Masters and PhD — email supervisor to discuss availability.

My PhD studies were focussed on image reconstruction algorithms for proton computed tomography (pCT). Proton CT differs from the common X-ray CT scanners by using energetic protons to traverse the body as opposed to kilovoltage X-rays. A measurement of the energy lost by protons as they traverse the body in pCT can be used to reconstruct a stopping power map of a patient. This information is useful in the emerging cancer treatment field of proton therapy.

Proton therapy is a highly conformal method of delivering therapeutic doses of radiation to treat cancer. Proton therapy has the advantage over the more common X-ray therapy that protons have a finite range in matter. Therefore, a beam of energetic protons can be directed at the cancer site, minimizing the dose to the surrounding healthy tissue. To be able to stop the proton beam at precisely the right location, an accurate map of proton stopping powers is required. This is the primary purpose of pCT.

The image reconstruction challenge in pCT stems from the fact that protons, as charged particles, interact with the electric fields of atomic electrons and nuclei in the patient tissues and undergo multiple scattering. Most image reconstruction algorithms assume the radiation travelled in a straight line between source and detector and when using this assumption in pCT, poor spatial resolution of the reconstructed image results. Special techniques are required to accurately account for the scattering of the protons in the patient.

In general, my research interests are focussed around proton therapy, including pCT and intensity modulated proton therapy optimization algorithms. I am also working to develop a toolkit that will provide clinicians with an estimate of the quality of life a patient can expext from multiple potential treatment options. This is of primary interest in proton therapy where the cose of treatment is significantly larger than X-ray therapy.

Appointments

Date Position Institution name
2013 Lecturer and Medical Physics Program Coordinator University of Adelaide
2010 Medical Physics Specialist Royal Adelaide Hospital

Awards and Achievements

Date Type Title Institution Name Country Amount
2009 Award Cancer Institute NSW Research Scholars Award Cancer Institute NSW Australia 25,000
2006 Award University Medal (Faculty of Engineering) University of Wollongong Australia

Education

Date Institution name Country Title
2003 - 2006 University of Wollongong Australia B Medical Radiation Physics (1st Class Honours)
University of Wollongong Australia PhD

Certifications

Date Title Institution name Country
2013 Certified Medical Physics Specialist (Radiation On Australasian College of Physical Scientists and Engineers in Medicine

Journals

Year Citation
2017 Zhu, J., & Penfold, S. (2017). Europium-155 as a source for dual energy cone beam computed tomography in adaptive proton therapy: A simulation study. Medical Physics, 44(10), 5143-5152.
DOI
2017 Penfold, S., & Zhu, J. (2017). Reply to "comment on 'Dosimetric comparison of stopping power calibration with dual-energy CT and single-energy CT in proton therapy treatment planning' [Med. Phys. 43(6), 2845-2854 (2016)]". Medical Physics, 44(10), 5537-5538.
DOI
2017 Austin, A., Douglass, M., Nguyen, G., & Penfold, S. (2017). A radiobiological Markov simulation tool for aiding decision making in proton therapy referral. Physica Medica, 44, 72-82.
DOI
2017 Penfold, S., Zalas, R., Casiraghi, M., Brooke, M., Censor, Y., & Schulte, R. (2017). Sparsity constrained split feasibility for dose-volume constraints in inverse planning of intensity-modulated photon or proton therapy. Physics in Medicine and Biology, 62(9), 3599-3618.
DOI
2016 Zhu, J., & Penfold, S. (2016). Dosimetric comparison of stopping power calibration with dual-energy CT and single-energy CT in proton therapy treatment planning. Medical Physics, 43(6), 2845-2854.
DOI Scopus13 Europe PMC9
2016 Incerti, S., Douglass, M., Penfold, S., Guatelli, S., & Bezak, E. (2016). Review of Geant4-DNA applications for micro and nanoscale simulations. Physica Medica, 32(10), 1187-1200.
DOI Scopus8 WoS6 Europe PMC2
2016 Zhu, J., & Penfold, S. (2016). Review of 3D image data calibration for heterogeneity correction in proton therapy treatment planning. Australasian Physical and Engineering Sciences in Medicine, 39(2), 379-390.
DOI
2016 Poignant, F., Penfold, S., Asp, J., & Takhar, P. (2016). GEANT4 simulation of cyclotron radioisotope production in a solid target. Physica Medica, 32(5), 728-734.
DOI Scopus1 WoS1
2015 Penfold, S., & Censor, Y. (2015). Techniques in Iterative Proton CT Image Reconstruction. Sensing and Imaging, 16(1), 21 pages.
DOI
2014 Penfold, S., Brown, M., Staudacher, A., & Bezak, E. (2014). Monte Carlo simulations of dose distributions with necrotic tumor targeted radioimmunotherapy. Applied Radiation and Isotopes, 90, 40-45.
DOI Scopus2 WoS2 Europe PMC1
2013 Douglass, M., Bezak, E., & Penfold, S. (2013). Monte Carlo investigation of the increased radiation deposition due to gold nanoparticles using kilovoltage and megavoltage photons in a 3D randomized cell model. Medical Physics, 40(7), 1-9.
DOI Scopus36 WoS31 Europe PMC14
2012 Penfold, S., Marcu, L., Lawson, J., & Asp, J. (2012). Evaluation of physician eye lens doses during permanent seed implant brachytherapy for prostate cancer. Journal of Radiological Protection, 32(3), 339-347.
DOI Scopus1 WoS1 Europe PMC1
2012 Douglass, M., Bezak, E., & Penfold, S. (2012). Development of a randomized 3D cell model for Monte Carlo microdosimetry simulations. Medical Physics, 39(6), 3509-3519.
DOI Scopus14 WoS14 Europe PMC9
2012 Schulte, R., & Penfold, S. (2012). Proton CT for improved stopping power determination in proton therapy. Transactions of the American Nuclear Society, 106, 55-58.
Scopus1 Europe PMC1
2011 Penfold, S., Rosenfeld, A., Schulte, R., & Sadrozinski, H. (2011). Geometrical optimazation of a particle tracking system for proton computed tomography. Radiation Measurements, 46(12), 2069-2072.
DOI
2010 Penfold, S., Schulte, R., Censor, Y., & Rosenfeld, A. (2010). Total variation superiorization schemes in proton computed tomography image reconstruction. Medical Physics, 37(11), 5887-5895.
DOI
2009 Penfold, S., Rosenfeld, A., Schulte, R., & Schubert, K. (2009). A more accurate reconstruction system matrix for quantitative proton computed tomography. Medical Physics, 36(10), 4511-4518.
DOI
2008 Schulte, R., Penfold, S., Tafas, J., & Schubert, K. (2008). A maximum likelihood proton path formalism for application in proton computed tomography. Medical Physics, 35(11), 4849-4856.
DOI

Book Chapters

Conference Papers

Year Citation
2009 Penfold, S., Rosenfeld, A., Schulte, R., & Sadrozinski, H. (2009). Fast and accurate proton computed tomography image reconstruction for applications in proton therapy. In World Congress on Medical Physics and Biomedical Engineering - Radiation Oncology; IFMBE Proceedings, vol. 25, no. 1 Vol. 25 (pp. 213-216). Germany: Springer.
DOI
2009 Wong, K., Erdelyi, B., Schulte, R., Bashkirov, V., Coutrakon, G., Sadrozinski, H., . . . Rosenfeld, A. (2009). The effect of tissue inhomogeneities on the accuracy of proton path reconstruction for proton computed tomography. In American Institute of Physics Proceedings: 20th International conference, application of accelerators in research and industry (pp. 476-480). Online: AIP Publishing.
2009 Bashkirov, V., Schulte, R., Coutrakon, G., Erdelyi, B., Wong, K., Sadrozinski, H., . . . Schubert, K. (2009). Development of proton computed tomography for applications in proton therapy. In AIP Proceedings: Application of Accelerators in Research and Industry: Twentieth International Conference (pp. 460-463). Online: AIP Publishing.

Theses

Year Citation
2014 Douglass, M. J. (2014). Development of an Integrated Stochastic Radiobiological Model for Electromagnetic Particle Interactions in a 4D Cellular Geometry. (PhD Thesis, University of Adelaide).

Current Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2017 Principal Supervisor Machine Learning in External Beam Radiotherapy Doctor of Philosophy Doctorate Full Time Mr James Alan Keal
2016 Principal Supervisor The Clinical Impact of Election Monte Carlo dose prescriptions in terms of dose to medium & dose to water Master of Philosophy Master Part Time Miss Hilary Frances Todd
2016 Principal Supervisor A radiobiology markov simulation tool for aiding decision making in proton therapy referral Doctor of Philosophy Doctorate Full Time Miss Annabelle Mary Austin
2015 Principal Supervisor Optical CT Scanner for In-Air Scanning of Radiochromic Gels in Radiotherapy 3D Dose Verification Doctor of Philosophy Doctorate Part Time Mr Daniel Paul Norman Ramm
2015 Principal Supervisor Investigating the Feasibility of Monte Carlo Simulation for Independent Photon Mu Verification Master of Philosophy Master Part Time Mr Stephen James Gibson
2013 Co-Supervisor Validation & Limitation of The Xio Mdo Electron Monte Carlo Module Master of Philosophy Master Part Time Mr Robert John Crane

Past Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2013 - 2015 Co-Supervisor Monte Carlo Conversion for the Australian Primary Standard of Absorbed Dose to Water in High Energy Photon Beams Master of Science (Medical Physics) Master Part Time Ms Tracy Elizabeth Wright
2012 - 2017 Principal Supervisor Dual Energy Image Reconstruction and Systems for Application in Proton Therapy Treatment Planning Doctor of Philosophy Doctorate Full Time Mr Jiahua Zhu
2011 - 2014 Co-Supervisor Development of an Integrated Stochastic Radiobiological Model for Electromagnetic Particle Interactions in a 4D Cellular Geometry Doctor of Philosophy Doctorate Part Time Mr Michael John James Douglass
Position
Lecturer
Phone
83133544
Fax
8313 4380
Campus
North Terrace
Building
Physics Building, floor G
Room Number
G 27
Org Unit
Physics

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