Associate Professor Sarah Vreugde
Grant-Funded Researcher (E)
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Associate Professor Sarah Vreugde
Senior Scientist Group: ENT Surgery
The Department of Otolaryngology, Head and Neck Surgery at The Queen Elizabeth Hospital is committed to excellence in translational research and education. Research in our department is focused mainly on understanding the pathogenesis of chronic rhinosinusitis (CRS), using a multidisciplinary approach, aimed at identifying new diagnostic/prognostic markers and treatment strategies to the benefit of our patients. Research projects cover all aspects of rhinological research from pathophysiological aspects of CRS to the identification and validation of new treatment strategies in vitro and in vivo, bringing research from bench to bedside.
Our Department of ENT has an excellent track record of Honours and Higher degree supervision with a 100% completion rate. Professor PJ Wormald was recognized for “Excellence in Research Supervision” by The University of Adelaide in 2013. We are always interested in students that have exceptional motivation and are passionate about research and in return we provide them with full support in terms of research supervision direction.
Projects in my laboratory are focused on diseases of the ear, nose and throat. In particular, my research is focused on pathophysiological aspects of chronic rhinosinusitis, aimed at the identification and validation of new diagnostic and treatment strategies in vitro and in vivo. Projects range from defining molecular mechanisms and microbial determinants of chronic inflammation to the validation of anti-bacterial and wound-healing compounds in vitro and in vivo.
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Appointments
Date Position Institution name 2017 - ongoing Associate Professor The University of Adelaide 2013 - 2016 Senior Scientist The University of Adelaide 2008 - 2011 Patent Examiner European Patent Office 2003 - 2006 Post-doctoral research scientist Istituto Scientifico San Raffaele (IRCCS), Milan 2003 - 2006 Consultant San Raffaele Hospital, Milan -
Language Competencies
Language Competency Dutch; Flemish Can read, write, speak, understand spoken and peer review English Can read, write, speak, understand spoken and peer review French Can read, write, speak, understand spoken and peer review German Can read, speak and understand spoken Hebrew Can speak and understand spoken Italian Can read, write, speak, understand spoken and peer review -
Education
Date Institution name Country Title 1998 - 2002 Tel Aviv University Israel PhD 1994 - 2000 Free University Brussels Belgium ENT Specialisation 1994 Free University Brussels Belgium MD -
Research Interests
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Journals
Year Citation 2023 Farnoud, A., Tofighian, H., Baumann, I., Ahookhosh, K., Pourmehran, O., Cui, X., . . . Schmid, O. (2023). Numerical and Machine Learning Analysis of the Parameters Affecting the Regionally Delivered Nasal Dose of Nano- and Micro-Sized Aerosolized Drugs. Pharmaceuticals, 16(1), 14 pages.
Scopus12023 Feizi, S., Cooksley, C. M., Ramezanpour, M., Nepal, R., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2023). Colloidal silver against macrophage infections and biofilms of atypical mycobacteria. BioMetals, 36(4), 913-925.
Scopus1 WoS12023 Dhakal, B., Li, C. M. Y., Ramezanpour, M., Houtak, G., Li, R., Bouras, G., . . . Fenix, K. (2023). Proteomic characterisation of perhexiline treatment on THP-1 M1 macrophage differentiation. Frontiers in Immunology, 14, 13 pages.
Scopus1 WoS1 Europe PMC12023 Shaghayegh, G., Cooksley, C., Bouras, G., Nepal, R., Houtak, G., Panchatcharam, B. S., . . . Vreugde, S. (2023). Staphylococcus aureus biofilm properties and chronic rhinosinusitis severity scores correlate positively with total CD4+ T-cell frequencies and inversely with its Th1, Th17 and regulatory cell frequencies. Immunology, 170(1), 120-133.
2023 Lee, J., Mashayamombe, M., Walsh, T. P., Kuang, B. K. P., Pena, G. N., Vreugde, S., . . . Kidd, S. P. (2023). The bacteriology of diabetic foot ulcers and infections and incidence of Staphylococcus aureus Small Colony Variants. Journal of Medical Microbiology, 72(6), 11 pages.
2023 Mascarenhas, A. R., Vediappan, R. S., Jukes, A. K., Bouras, G., Kaukas, L. M., Chryssidis, S., . . . Wormald, P. -J. (2023). Haemostatic efficacy and inflammatory response of a novel beta-chitin patch in a cerebral small vessel injury model - A pilot study.. J Clin Neurosci, 114, 70-76.
2023 Bouras, G., Sheppard, A. E., Mallawaarachchi, V., & Vreugde, S. (2023). Plassembler: an automated bacterial plasmid assembly tool. Bioinformatics, 39(7), 6 pages.
2023 Cherian, L. M., Liu, S., Hon, K., Ramezanpour, M., Hu, H., Javadiyan, S., . . . Vreugde, S. (2023). Hydrocortisone metabolism by Staphylococcus: Effects on anti-inflammatory and antimicrobial action. International Forum of Allergy and Rhinology, 5 pages.
2023 Pourmehran, O., Zarei, K., Pourchez, J., Vreugde, S., Psaltis, A., & Wormald, P. J. (2023). Advancements in acoustic drug delivery for paranasal sinuses: A comprehensive review. International Journal of Pharmaceutics, 644, 123277.
2023 Feizi, S., Awad, M., Nepal, R., Cooksley, C. M., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2023). Deferiprone-gallium-protoporphyrin (IX): A promising treatment modality against Mycobacterium abscessus. Tuberculosis, 142, 7 pages.
2023 Shaghayegh, G., Cooksley, C., Bouras, G., Houtak, G., Nepal, R., Psaltis, A. J., . . . Vreugde, S. (2023). S. aureus biofilm metabolic activity correlates positively with patients’ eosinophil frequencies and disease severity in chronic rhinosinusitis. Microbes and Infection, 105213--105213.
2023 Huang, S., Hon, K., Bennett, C., Hu, H., Menberu, M., Wormald, P. J., . . . Liu, S. (2023). Corrigendum: Corynebacterium accolens inhibits Staphylococcus aureus induced mucosal barrier disruption(Front. Microbiol., (2022), 13, (984741), 10.3389/fmicb.2022.984741). Frontiers in Microbiology, 14, 1279422.
2023 Vediappan, R. S., Bennett, C., Cooksley, C., Bassiouni, A., Scott, J. R., Al Suliman, Y. A., . . . Wormald, P. J. (2023). Wound healing in endoscopic sinus surgery: Phase 1 clinical trial evaluating the role of Chitogel with adjuvants. Clinical Otolaryngology, 48(2), 158-166.
Scopus1 WoS1 Europe PMC12023 Bouras, G., Nepal, R., Houtak, G., Psaltis, A. J., Wormald, P. -J., & Vreugde, S. (2023). Pharokka: a fast scalable bacteriophage annotation tool. Bioinformatics, 39(1), 1-4.
Scopus7 Europe PMC62023 Shaghayegh, G., Cooksley, C., Bouras, G. S., Panchatcharam, B. S., Idrizi, R., Jana, M., . . . Vreugde, S. (2023). Chronic rhinosinusitis patients display an aberrant immune cell localization with enhanced S aureus biofilm metabolic activity and biomass. Journal of Allergy and Clinical Immunology, 151(3), 723-736.e16.
2022 Hu, H., Liu, S., Hon, K., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2022). Staphylococcal protein A modulates inflammation by inducing interferon signaling in human nasal epithelial cells. Inflammation Research, 72(2), 1-12.
Scopus1 WoS1 Europe PMC12022 Mahnaz, R., Harrison, B., Hon, K., Gohar, S., Hadi, R., Aaron, F. K., . . . Sarah, V. (2022). Characterization of human nasal organoids from chronic rhinosinusitis patients.. Biology open, 11(8), 1-8.
Scopus1 WoS12022 Sabab, A., Vediappan, R. S., Finnie, J., McAdam, C. J., Jukes, A., Vreugde, S., & Wormald, P. J. (2022). Efficacy and Safety of Novel Beta-Chitin Patches as Haemostat in Rat Vascular and Neurosurgical Model. Frontiers in Surgery, 9, 1-9.
Scopus12022 Nepal, R., Houtak, G., Karki, S., Dhungana, G., Vreugde, S., & Malla, R. (2022). Genomic characterization of three bacteriophages targeting multidrug resistant clinical isolates of Escherichia, Klebsiella and Salmonella. Archives of Microbiology, 204(6), 1-9.
Scopus3 WoS2 Europe PMC22022 Liu, S., Hon, K., Bouras, G. S., Psaltis, A. J., Shearwin, K., Wormald, P. -J., & Vreugde, S. (2022). APTC-C-SA01: A Novel Bacteriophage Cocktail Targeting Staphylococcus aureus and MRSA Biofilms. International Journal of Molecular Sciences, 23(11), 1-18.
Scopus4 WoS2 Europe PMC22022 Shaghayegh, G., Cooksley, C., Ramezanpour, M., Wormald, P. J., Psaltis, A. J., & Vreugde, S. (2022). Chronic Rhinosinusitis, S. aureus Biofilm and Secreted Products, Inflammatory Responses, and Disease Severity. Biomedicines, 10(6), 28 pages.
Scopus5 WoS5 Europe PMC12022 Goggin, R. K., Bennett, C. A., Cooksley, C. M., Bassiouni, A., Bialasiewicz, S., Wormald, P. J., . . . Psaltis, A. J. (2022). Viral presence and the bacterial microbiome in chronic rhinosinusitis. Australian Journal of Otolaryngology, 5, 11.
2022 Huang, S., Hon, K., Bennett, C., Hu, H., Menberu, M., Wormald, P. J., . . . Liu, S. (2022). Corynebacterium accolens inhibits Staphylococcus aureus induced mucosal barrier disruption. Frontiers in Microbiology, 13, 11 pages.
Scopus3 Europe PMC22022 Lee, J., Carda-Diéguez, M., Žiemytė, M., Vreugde, S., Cooksley, C., Crosby, H. A., . . . Kidd, S. P. (2022). Functional
<i>mgrA</i>
Influences Genetic Changes within a Staphylococcus aureus Cell Population over Time. Journal of Bacteriology, 204(10), 21 pages.
Scopus1 WoS1 Europe PMC12022 Hon, K., Liu, S., Cooksley, C., Vreugde, S., & Psaltis, A. J. (2022). Low pH nasal rinse solution enhances mupirocin antimicrobial efficacy. Rhinology, 60(3), 218-228.
2022 Javadiyan, S., Cooksley, C. M., Bouras, G. S., Kao, S. S. T., Bennett, C. A., Wormald, P. J., . . . Psaltis, A. J. (2022). Investigation of Kappa Carrageenan's muco-adhesive, antibacterial, and anti-biofilm properties. International Forum of Allergy and Rhinology, 12(3), 302-305.
Scopus1 WoS12022 Menberu, M. A., Cooksley, C., Ramezanpour, M., Bouras, G., Wormald, P. -J., Psaltis, A. J., & Vreugde, S. (2022). In vitro and in vivo evaluation of probiotic properties of Corynebacterium accolens isolated from the human nasal cavity. Microbiological Research, 255, 10 pages.
Scopus2 WoS12022 Feizi, S., Cooksley, C. M., Nepal, R., Psaltis, A. J., Wormald, P. -J., & Vreugde, S. (2022). Silver nanoparticles as a bioadjuvant of antibiotics against biofilm-mediated infections with methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa in chronic rhinosinusitis patients. Pathology, 54(4), 453-459.
Scopus6 WoS6 Europe PMC42022 Shrestha, K., Van Strien, J., Shang, Y., Fletcher, D. F., Petersen, P., Vreugde, S., . . . Inthavong, K. (2022). Effect of breathing profiles on nebuliser drug delivery targeting the paranasal sinuses in a post-operative nasal cavity. Journal of Aerosol Science, 161, 1-19.
Scopus6 WoS52022 Hon, K., Liu, S., Camens, S., Bouras, G. S., Psaltis, A. J., Wormald, P. -J., & Vreugde, S. (2022). APTC-EC-2A: A Lytic Phage Targeting Multidrug Resistant E. coli Planktonic Cells and Biofilms. Microorganisms, 10(1), 1-18.
Scopus4 WoS4 Europe PMC22022 Nepal, R., Houtak, G., Wormald, P. -J., Psaltis, A. J., & Vreugde, S. (2022). Prophage: a crucial catalyst in infectious disease modulation. The Lancet Microbe, 3(3), e162-e163.
Scopus2 WoS1 Europe PMC12022 Hon, K., Liu, S., Cooksley, C., Vreugde, S., & Psaltis, A. J. (2022). Low pH nasal rinse solution enhances mupirocin antimicrobial efficacy.. Rhinology, 60(3), 218-228.
2022 Megow, A., Alsuliman, Y., Bouras, G., Menberu, M., Vyskocil, E., Vreugde, S., & Wormald, P. -J. (2022). Chitogel following endoscopic sinus surgery promotes a healthy microbiome and reduces post-operative infections.. International forum of allergy & rhinology, 12(11), 1362-1376.
Scopus2 WoS2 Europe PMC22022 Javadiyan, S., Germein, K. C., Cooksley, C. M., Ramezanpour, M., Singh, N., Wormald, P. -J., . . . Psaltis, A. J. (2022). In Vitro safety and anti-bacterial efficacy assessment of Acriflavine.. Allergy, 77(6), 1917-1920.
2021 Suzuki, M., Cooksley, C., Suzuki, T., Ramezanpour, M., Nakazono, A., Nakamaru, Y., . . . Vreugde, S. (2021). TLR Signals in Epithelial Cells in the Nasal Cavity and Paranasal Sinuses. Frontiers in Allergy, 2, 780425-1-780425-11.
Scopus3 Europe PMC12021 Vahaji, S., Shang, Y., Zhang, Y., Wong, E., Rezk, A., Yeo, L., . . . Inthavong, K. (2021). Optimising Aerosol Delivery for Maxillary Sinus Deposition in a Post-FESS Sinonasal Cavities. AEROSOL AND AIR QUALITY RESEARCH, 21(12), 16 pages.
Scopus2 WoS22021 Nepal, R., Houtak, G., Shaghayegh, G., Bouras, G., Shearwin, K., Psaltis, A. J., . . . Vreugde, S. (2021). Prophages encoding human immune evasion cluster genes are enriched in Staphylococcus aureus isolated from chronic rhinosinusitis patients with nasal polyps. Microbial Genomics, 7(12), 1-19.
Scopus9 WoS8 Europe PMC82021 Ogi, K., Liu, S., Ramezanpour, M., Cooksley, C., Javadiyan, S., Fujieda, S., . . . Psaltis, A. J. (2021). Trimellitic anhydride facilitates transepithelial permeability disrupting tight junctions in sinonasal epithelial cells. Toxicology Letters, 353, 27-33.
Scopus2 WoS2 Europe PMC22021 Feizi, S., Javadiyan, S., Cooksley, C. M., Shaghayegh, G., Psaltis, A. J., Wormald, P., & Vreugde, S. (2021). Green synthesized colloidal silver is devoid of toxic effects on primary human nasal epithelial cells in vitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 157, 112606-1-112606-10.
Scopus2 WoS2 Europe PMC12021 Sabab, A., Vreugde, S., Jukes, A., & Wormald, P. J. (2021). The potential of chitosan-based haemostats for use in neurosurgical setting – Literature review. Journal of Clinical Neuroscience, 94, 128-134.
Scopus4 Europe PMC12021 Ramezanpour, M., Bolt, H., Hon, K., Bouras, G. S., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2021). Cytokine-induced modulation of sars-cov2 receptor expression in primary human nasal epithelial cells. Pathogens, 10(7), 18 pages.
Scopus2 Europe PMC22021 Ramezanpour, M., Ogi, K., Liu, S., Tuli, J. F., Bennett, C., Masanobu, S., . . . Vreugde, S. (2021). Der p 1 disrupts the epithelial barrier and induces IL-6 production in patients with house dust mite allergic rhinitis. Frontiers in Allergy, 2, 1-9.
Scopus7 Europe PMC22021 Rastin, H., Mansouri, N., Tung, T. T., Hassan, K., Mazinani, A., Ramezanpour, M., . . . Losic, D. (2021). Converging 2D nanomaterials and 3D bioprinting technology: state-of-the-art, challenges, and potential outlook in biomedical applications. Advanced Healthcare Materials, 10(22), e2101439-1-e2101439-50.
Scopus7 WoS8 Europe PMC22021 Sabab, A., Liu, S., Javadiyan, S., McAdam, C. J., Hanton, L. R., Jukes, A., . . . Wormald, P. -J. (2021). The effect of chemical and structural modifiers on the haemostatic process and cytotoxicity of the beta-chitin patch. Scientific Reports, 11(1), 1-15.
Scopus2 WoS2 Europe PMC12021 Camens, S., Hon, K., Liu, S., Bouras, G. S., Psaltis, A. J., Wormald, P., & Vreugde, S. (2021). Preclinical Development of a Bacteriophage Cocktail for Treating Multidrug Resistant Pseudomonas aeruginosa Infections. Microorganisms, 9(9), 2001-1-2001-16.
Scopus8 WoS6 Europe PMC72021 Menberu, M. A., Hayes, A. J., Liu, S., Psaltis, A. J., Wormald, P. -J., & Vreugde, S. (2021). Tween 80 and its derivative oleic acid promote the growth of Corynebacterium accolens and inhibit Staphylococcus aureus clinical isolates. Int Forum Allergy Rhinol, 11(4), 810-813.
Scopus4 WoS4 Europe PMC32021 Vediappan, R. S., Bennett, C., Cooksley, C., Finnie, J., Trochsler, M., Quarrington, R. D., . . . Wormald, P. J. (2021). Prevention of adhesions post-abdominal surgery: Assessing the safety and efficacy of Chitogel with Deferiprone in a rat model. PLoS One, 16(1), e0244503-1-e0244503-17.
Scopus4 WoS4 Europe PMC12021 Suzuki, M., Ramezanpour, M., Cooksley, C., Ogi, K., Psaltis, A. J., Nakamaru, Y., . . . Vreugde, S. (2021). Metallothionein-3 is a clinical biomarker for tissue zinc levels in nasal mucosa. Auris Nasus Larynx, 48(5), 890-897.
Scopus1 WoS1 Europe PMC12021 Menberu, M. A., Liu, S., Cooksley, C., Hayes, A. J., Psaltis, A. J., Wormald, P. -J., & Vreugde, S. (2021). Corynebacterium accolens Has Antimicrobial Activity against Staphylococcus aureus and Methicillin-Resistant S. aureus Pathogens Isolated from the Sinonasal Niche of Chronic Rhinosinusitis Patients. Pathogens, 10(2), 1-19.
Scopus24 WoS20 Europe PMC132021 Feizi, S., Cooksley, C. M., Bouras, G. S., Prestidge, C. A., Coenye, T., Psaltis, A. J., . . . Vreugde, S. (2021). Colloidal silver combating pathogenic Pseudomonas aeruginosa and MRSA in chronic rhinosinusitis.. Colloids and surfaces. B, Biointerfaces, 202, 1-10.
Scopus11 WoS13 Europe PMC52021 Rastin, H., Ramezanpour, M., Hassan, K., Mazinani, A., Tung, T. T., Vreugde, S., & Losic, D. (2021). 3D bioprinting of a cell-laden antibacterial polysaccharide hydrogel composite. Carbohydrate Polymers, 264, 117989-1-117989-12.
Scopus45 WoS40 Europe PMC182021 Liu, S., Zhao, Y., Hayes, A., Hon, K., Zhang, G., Bennett, C., . . . Vreugde, S. (2021). Overcoming bacteriophage insensitivity in Staphylococcus aureus using clindamycin and azithromycinat sub-inhibitory concentrations. Allergy, 76(11), 3446-3458.
Scopus6 WoS5 Europe PMC42021 Nakazono, A., Nakamaru, Y., Ramezanpour, M., Kondo, T., Watanabe, M., Hatakeyama, S., . . . Homma, A. (2021). Fluticasone Propionate Suppresses Poly(I:C)-Induced ACE2 in Primary Human Nasal Epithelial Cells. Frontiers in Cellular and Infection Microbiology, 11, 1-10.
Scopus10 WoS9 Europe PMC82021 Tuli, J. F., Ramezanpour, M., Cooksley, C., Psaltis, A. J., Wormald, P. -J., & Vreugde, S. (2021). Association between mucosal barrier disruption by Pseudomonas aeruginosa exoproteins and asthma in patients with chronic rhinosinusitis.. Allergy, 76(11), 3459-3469.
Scopus13 WoS11 Europe PMC82021 Cherian, L. M., Bassiouni, A., Cooksley, C. M., Vreugde, S., Wormald, P., & Psaltis, A. J. (2021). The clinical outcomes of medical therapies in chronic rhinosinusitis is independent of microbiomic outcomes: a double-blinded, randomised placebo-controlled trial.. Rhinology, 58(3), 386-390.
Scopus8 WoS9 Europe PMC32021 Kao, S., Bassiouni, A., Ramezanpour, M., Finnie, J., Chegeni, N., Colella, A. D., . . . Psaltis, A. J. (2021). Proteomic analysis of nasal mucus samples of healthy and chronic rhinosinusitis patients. J Allergy Clin Immunol, 147(1), 168-178.
Scopus23 WoS21 Europe PMC142021 Connell, J., Bassiouni, A., Wormald, P., Vreugde, S., & Psaltis, A. (2021). Optimal primer selection for sinus microbiome profiling: A comparative analysis of the V1‐V3 and V3‐4 16S target regions. International Forum of Allergy & Rhinology, 11(12), 1698-1702.
2021 Mazinani, A., Rastin, H., Nine, M. J., Lee, J., Tikhomirova, A., Tung, T. T., . . . Losic, D. (2021). Comparative antibacterial activity of 2D materials coated on the porous-titania. Journal of Materials Chemistry B, 32(32), 6412-6424.
Scopus9 WoS8 Europe PMC42021 Pourmehran, O., Arjomandi, M., Cazzolato, B., Tian, Z., Vreugde, S., Javadiyan, S., . . . Wormald, P. -J. (2021). Acoustic drug delivery to the maxillary sinus.. Int J Pharm, 606, 1-15.
Scopus14 WoS12 Europe PMC62020 Ooi, M. L., Drilling, A. J., James, C., Moratti, S., Vreugde, S., Psaltis, A. J., & Wormald, P. J. (2020). Efficacy of anti-biofilm gel, chitogel-mupirocin-budesonide in a sheep sinusitis model. Australian Journal of Otolaryngology(Hong Kong), 3(May), 8 pages.
Scopus12020 Ramezanpour, M., Hu, H., Lau, A., Liu, S., De Silva, A., Bolt, H., . . . Vreugde, S. (2020). Increased serum IgG4 associates with asthma and tissue eosinophilia in chronic rhinosinusitis patients. Pathogens, 9(10), 1-6.
Scopus1 WoS12020 Suzuki, M., Suzuki, T., Watanabe, M., Hatakeyama, S., Kimura, S., Nakazono, A., . . . Homma, A. (2020). Role of intracellular zinc in molecular and cellular function in allergic inflammatory diseases. Allergology International, 70(2), 190-200.
Scopus12 Europe PMC72020 Paramasivan, S., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2020). Tertiary Lymphoid Organs: A Primer for Otolaryngologists.. Laryngoscope, 131(8), 1697-1703.
Scopus1 WoS12020 Suzuki, M., Ramezanpour, M., Cooksley, C., Lee, T. J., Jeong, B., Kao, S., . . . Vreugde, S. (2020). Zinc-depletion associates with tissue eosinophilia and collagen depletion in chronic rhinosinusitis. Rhinology, 58(5), 451-459.
Scopus8 WoS3 Europe PMC12020 Kao, S. S. T., Ramezanpour, M., Bassiouni, A., Finnie, J., Wormald, P. J., Vreugde, S., & Psaltis, A. J. (2020). Barrier disruptive effects of mucus isolated from chronic rhinosinusitis patients. Allergy: European Journal of Allergy and Clinical Immunology, 75(1), 3 pages.
Scopus11 WoS12 Europe PMC42020 Curragh, D. S., Bassiouni, A., Macias-Valle, L., Vreugde, S., Wormald, P. -J., Selva, D., & Psaltis, A. J. (2020). The Microbiome of the Nasolacrimal System and Its Role in Nasolacrimal Duct Obstruction. Ophthalmic plastic and reconstructive surgery, 36(1), 80-85.
Scopus6 WoS4 Europe PMC22020 Dong, D., Thomas, N., Ramezanpour, M., Alkis, P., Huang, S., Zhao, Y., . . . Vreudge, S. (2020). Inhibition of Staphylococcus aureus and Pseudomonas aeruginosa biofilms by quatsomes in low concentrations. Experimental Biology and Medicine, 245(1), 34-41.
Scopus13 WoS14 Europe PMC52020 Vediappan, R. S., Mascarenhas, A., Nguyen-Hoang, A., Fong, S. A., Jukes, A., Richter, K., . . . Wormald, P. (2020). Prevention of peridural adhesions in spinal surgery: assessing safety and efficacy of Chitogel with Deferiprone in a sheep model. Journal of Clinical Neuroscience, 72, 378-385.
Scopus6 WoS5 Europe PMC22020 Bassiouni, A., Ou, J., Schreiber, A., Geoghegan, J., Tsykin, A., Psaltis, A. J., . . . Vreugde, S. (2020). The global transcriptomic signature in sinonasal tissues reveals roles for tissue type and chronic rhinosinusitis disease phenotype. Rhinology, 58(3), 273-283.
Scopus8 WoS8 Europe PMC42020 Paramasivan, S., Bassiouni, A., Shiffer, A., Dillon, M. R., Cope, E. K., Cooksley, C., . . . Psaltis, A. J. (2020). The international sinonasal microbiome study (ISMS): a multi-centre, multi-national characterization of sinonasal bacterial ecology. Allergy, 75(8), 2033-2045.
Scopus35 WoS35 Europe PMC172020 Gouzos, M., Ramezanpour, M., Bassiouni, A., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2020). Antibiotics affect ROS production and fibroblast migration in an in-vitro model of sinonasal wound healing. Frontiers in Cellular and Infection Microbiology, 10, 110-1-110-12.
Scopus12 WoS8 Europe PMC62020 Bassiouni, A., Paramasivan, S., Shiffer, A., Dillon, M. R., Cope, E. K., Cooksley, C., . . . Psaltis, A. J. (2020). Microbiotyping the Sinonasal Microbiome.. Frontiers in Cellular and Infection Microbiology, 10, 137.
Scopus14 WoS12 Europe PMC62020 Vediappan, R. S., Bennett, C., Bassiouni, A., Smith, M., Finnie, J., Trochsler, M., . . . Wormald, P. J. (2020). A novel rat model to test intra-abdominal anti-adhesive therapy. Frontiers in Surgery, 7, 12.
Scopus7 WoS5 Europe PMC22020 Goggin, R., Bennett, C., Ramezanpour, M., Hu, H., Fenix, K., Bassiouni, A., . . . Vreugde, S. (2020). Association between viral infection and increased mucosal eosinophils and CD8<sup>+</sup>CD103<sup>+</sup> T cells in chronic rhinosinusitis. International Forum of Allergy and Rhinology, 10(8), 978-980.
2020 Ramezanpour, M., Smith, J. P., Pstaltis, A. J., Wormald, P. J., & Vreugde, S. (2020). In vitro safety evaluation of a povidone‐iodine solution applied to human nasal epithelial cells. International Forum of Allergy and Rhinology, 10(10), 1141-1148.
Scopus27 WoS23 Europe PMC112020 Ramezanpour, M., Kao, S., Bassiouni, A., Chegeni, N., Colella, A., Chataway, K., . . . Psaltis, A. (2020). Scoping review of chronic rhinosinusitis proteomicsc rhinosinusitis proteomics. Rhinology, 58(5), 418-470.
2020 Panchatcharam, B. S., Cooksley, C. M., Ramezanpour, M., Vediappan, R. S., Bassiouni, A., Wormald, P. J., . . . Vreugde, S. (2020). Staphylococcus aureus biofilm exoproteins are cytotoxic to human nasal epithelial barrier in Chronic Rhinosinusitis. International Forum of Allergy and Rhinology, 10(7), 871-883.
Scopus14 WoS14 Europe PMC72020 Kao, S. S. -T., Bassiouni, A., Ramezanpour, M., Chegeni, N., Colella, A. D., Chataway, T. K., . . . Psaltis, A. J. (2020). Scoping review of chronic rhinosinusitis proteomics.. Rhinology, 58(5), 418-470.
Scopus8 WoS8 Europe PMC32019 Ooi, M., Drilling, A., Morales, S., Fong, S., Moraitis, S., MacIas-Valle, L., . . . Wormald, P. (2019). Safety and tolerability of bacteriophage therapy for chronic rhinosinusitis due to staphylococcus aureus. JAMA Otolaryngology-Head and Neck Surgery, 145(8), 723-729.
Scopus87 WoS68 Europe PMC582019 Govindaraju, R., Cherian, L., Macias-Valle, L., Murphy, J., Gouzos, M., Vreugde, S., . . . Psaltis, A. J. (2019). Extent of maxillary sinus surgery and its effect on instrument access, irrigation penetration, and disease clearance. International Forum of Allergy and Rhinology, 9(10), 1097-1104.
Scopus14 WoS13 Europe PMC62019 Kao, S. S. T., Ramezanpour, M., Bassiouni, A., Wormald, P. J., Psaltis, A. J., & Vreugde, S. (2019). The effect of neutrophil serine proteases on human nasal epithelial cell barrier function. International Forum of Allergy and Rhinology, 9(10), 7 pages.
Scopus21 WoS20 Europe PMC132019 Ooi, M. L., Jothin, A., Bennett, C., Ooi, E. H., Vreugde, S., Psaltis, A. J., & Wormald, P. J. (2019). Manuka honey sinus irrigations in recalcitrant chronic rhinosinusitis: phase 1 randomized, single-blinded, placebo-controlled trial. International Forum of Allergy and Rhinology, 9(12), 1470-1477.
Scopus15 WoS16 Europe PMC72019 Hu, H., Ramezanpour, M., Hayes, A. J., Liu, S., Psaltis, A. J., Wormald, P., & Vreugde, S. (2019). Sub-Inhibitory Clindamycin and Azithromycin reduce S. aureus Exoprotein Induced Toxicity, Inflammation, Barrier Disruption and Invasion.. Journal of clinical medicine, 8(10), 16 pages.
Scopus14 WoS14 Europe PMC102019 Murphy, J., Ramezanpour, M., Drilling, A., Roscioli, E., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2019). In vitro characteristics of an airway barrier-disrupting factor secreted by Staphylococcus aureus. International Forum of Allergy and Rhinology, 9(2), 187-196.
Scopus8 WoS9 Europe PMC62019 Fong, S. A., Drilling, A. J., Ooi, M. L., Paramasivan, S., Finnie, J. W., Morales, S., . . . Wormald, P. J. (2019). Safety and efficacy of a bacteriophage cocktail in an in vivo model of Pseudomonas aeruginosa sinusitis. Translational Research, 206, 41-56.
Scopus22 WoS22 Europe PMC122019 Ramezanpour, M., Bolt, H., Psaltis, A., Wormald, P. J., & Vreugde, S. (2019). Inducing a Mucosal Barrier–Sparing Inflammatory Response in Laboratory-Grown Primary Human Nasal Epithelial Cells. Current Protocols in Toxicology, 80(1), e69.
Scopus14 Europe PMC52019 Cherian, L. M., Cooksley, C., Richter, K., Ramezanpour, M., Paramasivan, S., Wormald, P. J., . . . Psaltis, A. J. (2019). Effect of commercial nasal steroid preparation on bacterial growth. International Forum of Allergy and Rhinology, 9(7), 766-775.
Scopus7 WoS7 Europe PMC12019 Ramezanpour, M., Smith, J. L. P., Ooi, M. L., Gouzos, M., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2019). Deferiprone has anti-inflammatory properties and reduces fibroblast migration in vitro. Scientific Reports, 9(1), 9 pages.
Scopus13 WoS12 Europe PMC102019 Li, J., Ramezanpour, M., Fong, S. A., Cooksley, C., Murphy, J., Suzuki, M., . . . Vreugde, S. (2019). Pseudomonas aeruginosa exoprotein-induced barrier disruption correlates with elastase activity and marks Chronic Rhinosinusitis severity. Frontiers in Cellular and Infection Microbiology, 9, 9 pages.
Scopus23 WoS20 Europe PMC142019 Goggin, R. K., Bennett, C. A., Bialasiewicz, S., Vediappan, R. S., Vreugde, S., Wormald, P. J., & Psaltis, A. J. (2019). The presence of virus significantly associates with chronic rhinosinusitis disease severity. Allergy: European Journal of Allergy and Clinical Immunology, 74(8), 1569-1572.
Scopus13 WoS10 Europe PMC52019 Bennett, C., Ramezanpour, M., Cooksley, C., Vreugde, S., & Psaltis, A. J. (2019). Kappa-carrageenan sinus rinses reduce inflammation and intracellular Staphylococcus aureus infection in airway epithelial cells. International Forum of Allergy and Rhinology, 9(8), 918-925.
Scopus8 WoS7 Europe PMC32018 Ooi, M., Richter, K., Bennett, C., Macias-Valle, L., Vreugde, S., Psaltis, A., & Wormald, P. (2018). Topical colloidal silver for the treatment of recalcitrant chronic rhinosinusitis. Frontiers in Microbiology, 9(APR), 1-7.
Scopus14 WoS14 Europe PMC72018 Ooi, M., Richter, K., Drilling, A., Thomas, N., Prestidge, C. A., James, C., . . . Wormald, P. J. (2018). Safety and efficacy of topical chitogel- deferiprone- gallium protoporphyrin in a sheep sinusitis model. Frontiers in Microbiology, 9(MAY), 9 pages.
Scopus12 WoS12 Europe PMC72018 Suzuki, M., Ramezanpour, M., Cooksley, C., Li, J., Nakamaru, Y., Homma, A., . . . Vreugde, S. (2018). Sirtuin-1 Controls Poly (I:C)-Dependent Matrix Metalloproteinase 9 Activation in Primary Human Nasal Epithelial Cells. American journal of respiratory cell and molecular biology, 59(4), 500-510.
Scopus16 WoS16 Europe PMC102018 Murphy, J., Ramezanpour, M., Roscioli, E., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2018). Mucosal zinc deficiency in chronic rhinosinusitis with nasal polyposis contributes to barrier disruption and decreases ZO-1. Allergy: European Journal of Allergy and Clinical Immunology, 73(10), 2095-2097.
Scopus20 WoS18 Europe PMC52018 Ramezanpour, M., Bolt, H., Psaltis, A., Wormald, P., & Vreugde, S. (2018). Primary human nasal epithelial cells: a source of poly (I:C) LMW-induced IL-6 production. Scientific Reports, 8(1), 8 pages.
Scopus20 WoS19 Europe PMC122018 Zhang, G., Zhao, Y., Hayes, A. J., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2018). Staphylococcus aureus small colony variants: Prevalence in chronic rhinosinusitis and induction by antibiotics. Allergy: European Journal of Allergy and Clinical Immunology, 73(12), 2403-2405.
Scopus4 WoS4 Europe PMC22018 Paramasivan, S., Lester, S., Lau, A., Ou, J., Psaltis, A., Wormald, P., & Vreugde, S. (2018). Tertiary lymphoid organs: A novel target in patients with chronic rhinosinusitis. Journal of Allergy and Clinical Immunology, 142(5), 1673-1676.
Scopus8 WoS8 Europe PMC22018 Goggin, R., Bennett, C., Bassiouni, A., Bialasiewicz, S., Vreugde, S., Wormald, P., & Psaltis, A. (2018). Comparative viral sampling in the sinonasal passages; Different viruses at different sites. Frontiers in Cellular and Infection Microbiology, 8(SEP), 8 pages.
Scopus8 WoS7 Europe PMC22018 Bardy, J., Sarovich, D., Price, E., Steinig, E., Tong, S., Drilling, A., . . . Psaltis, A. (2018). Staphylococcus aureus from patients with chronic rhinosinusitis show minimal genetic association between polyp and non-polyp phenotypes 06 Biological Sciences 0604 Genetics. BMC Ear, Nose and Throat Disorders, 18(1), 16.
Scopus5 Europe PMC52018 Zhao, Y., Bassiouni, A., Tanjararak, K., Vreugde, S., Wormald, P., & Psaltis, A. (2018). Role of fungi in chronic rhinosinusitis through ITS sequencing. Laryngoscope, 128(1), 16-22.
Scopus25 WoS22 Europe PMC162018 Murphy, J., Ramezanpour, M., Stach, N., Dubin, G., Psaltis, A., Wormald, P., & Vreugde, S. (2018). Staphylococcus Aureus V8 protease disrupts the integrity of the airway epithelial barrier and impairs IL-6 production in vitro. Laryngoscope, 128(1), 8-15.
Scopus37 WoS30 Europe PMC172018 Zhang, G., Zhao, Y., Paramasivan, S., Richter, K., Morales, S., Wormald, P., & Vreugde, S. (2018). Bacteriophage effectively kills multidrug resistant Staphylococcus aureus clinical isolates from chronic rhinosinusitis patients. International Forum of Allergy and Rhinology, 8(3), 406-414.
Scopus32 WoS31 Europe PMC212018 Miljkovic, D., Psaltis, A., Wormald, P., & Vreugde, S. (2018). Naive and effector B-cell subtypes are increased in chronic rhinosinusitis with polyps. American Journal of Rhinology and Allergy, 32(1), 3-6.
Scopus8 WoS7 Europe PMC42017 Miljkovic, D., Psaltis, A., Wormald, P., & Vreugde, S. (2017). Chronic rhinosinusitis with polyps is characterized by increased mucosal and blood Th17 effector cytokine producing cells. Frontiers in Physiology, 8(DEC), 7 pages.
Scopus9 WoS8 Europe PMC62017 Fong, S., Drilling, A., Morales, S., Cornet, M., Woodworth, B., Fokkens, W., . . . Wormald, P. (2017). Activity of bacteriophages in removing biofilms of pseudomonas aeruginosa isolates from chronic rhinosinusitis patients. Frontiers in Cellular and Infection Microbiology, 7(SEP), 1-11.
Scopus96 WoS93 Europe PMC532017 Ramezanpour, M., Murphy, J., Smith, J., Vreugde, S., & Psaltis, A. (2017). In vitro safety evaluation of human nasal epithelial cell monolayers exposed to carrageenan sinus wash. International Forum of Allergy and Rhinology, 7(12), 1170-1177.
Scopus23 WoS19 Europe PMC62017 Oue, S., Ramezanpour, M., Paramasivan, S., Miljkovic, D., Cooksley, C. M., Bassiouni, A., . . . Vreugde, S. (2017). Increased IL-13 expression is independently associated with neo-osteogenesis in patients with chronic rhinosinusitis. Journal of Allergy and Clinical Immunology, 140(5), 1444-1448.e11.
Scopus11 WoS11 Europe PMC62017 Richter, K., Facal, P., Thomas, N., Vandecandelaere, I., Ramezanpour, M., Cooksley, C., . . . Vreugde, S. (2017). Taking the silver bullet colloidal silver particles for the topical treatment of biofilm-related infections. ACS Applied Materials and Interfaces, 9(26), 21631-21638.
Scopus41 WoS38 Europe PMC152017 Richter, K., Thomas, N., Zhang, G., Prestidge, C., Coenye, T., Wormald, P. -J., & Vreugde, S. (2017). Deferiprone and gallium-protoporphyrin have the capacity to potentiate the activity of antibiotics in Staphylococcus aureus small colony variants. Frontiers in Cellular and Infection Microbiology, 7(JUN), 280-1-280-10.
Scopus44 WoS36 Europe PMC192017 Ou, J., Bassiouni, A., Drilling, A., Psaltis, A., Vreugde, S., & Wormald, P. (2017). The persistence of intracellular Staphylococcus aureus in the sinuses: a longitudinal study.. Rhinology, 55(4), 305-311.
Scopus14 WoS14 Europe PMC82017 Ramezanpour, M., Rayan, A., Smith, J., & Vreugde, S. (2017). The effect of topical treatments for CRS on the sinonasal epithelial barrier. Rhinology, 55(2), 161-169.
Scopus12 WoS11 Europe PMC52017 Chan, C., Richter, K., Wormald, P., Psaltis, A., & Vreugde, S. (2017). Alloiococcus otitidis forms multispecies biofilm with Haemophilus influenzae: effects on antibiotic susceptibility and Growth in Adverse Conditions. Frontiers in Cellular and Infection Microbiology, 7(AUG), 344-1-344-9.
Scopus20 WoS17 Europe PMC102017 Jukes, A., Murphy, J., Vreugde, S., Psaltis, A., & Wormald, P. (2017). Nano-hemostats and a Pilot Study of Their Use in a Large Animal Model of Major Vessel Hemorrhage in Endoscopic Skull Base Surgery. Journal of Neurological Surgery, Part B: Skull Base, 78(3), 215-221.
Scopus2 WoS2 Europe PMC12017 Lau, A., Lester, S., Moraitis, S., Ou, J., Psaltis, A., McColl, S., . . . Vreugde, S. (2017). Tertiary lymphoid organs in recalcitrant chronic rhinosinusitis. Journal of Allergy and Clinical Immunology, 139(4), 1371-1373.
Scopus18 WoS18 Europe PMC52017 Miljkovic, D., Ou, J., Kirana, C., Hulse, K., Hauben, E., Psaltis, A., . . . Vreugde, S. (2017). Discordant frequencies of tissue-resident and circulating CD180-negative B cells in chronic rhinosinusitis. International Forum of Allergy and Rhinology, 7(6), 609-614.
Scopus4 WoS4 Europe PMC12017 Drilling, A., Ooi, M., Miljkovic, D., James, C., Speck, P., Vreugde, S., . . . Wormald, P. (2017). Long-term safety of topical bacteriophage application to the frontal sinus region. Frontiers in Cellular and Infection Microbiology, 7(FEB), 1-8.
Scopus33 WoS30 Europe PMC212017 Chan, C., Wabnitz, D., Bassiouni, A., Wormald, P., Vreugde, S., & Psaltis, A. (2017). Identification of the bacterial reservoirs for the middle ear using phylogenic analysis. JAMA Otolaryngology - Head and Neck Surgery, 143(2), 155-161.
Scopus25 WoS22 Europe PMC162017 Richter, K., Thomas, N., Claeys, J., McGuane, J., Prestidge, C., Coenye, T., . . . Vreugde, S. (2017). A topical hydrogel with deferiprone and gallium-protoporphyrin targets bacterial iron metabolism and has antibiofilm activity. Antimicrobial Agents and Chemotherapy, 61(6), e00481-17-1-e00481-17-11.
Scopus54 WoS51 Europe PMC262016 Chan, C., Wabnitz, D., Bardy, J., Bassiouni, A., Wormald, P., Vreugde, S., & Psaltis, A. (2016). The microbiome of otitis media with effusion. Laryngoscope, 126(12), 2844-2851.
Scopus50 WoS48 Europe PMC322016 Vreugde, S., & Wormald, P. (2016). Innate lymphoid type 2 cells in chronic rhinosinusitis. Current Opinion in Allergy and Clinical Immunology, 16(1), 7-12.
Scopus5 WoS4 Europe PMC22016 Bassiouni, A., Ou, J., Rajiv, S., Cantero, D., Vreugde, S., & Wormald, P. (2016). Subepithelial inflammatory load and basement membrane thickening in refractory chronic rhinosinusitis with nasal polyposis: A histopathological study. International Forum of Allergy and Rhinology, 6(3), 248-255.
Scopus32 WoS29 Europe PMC162016 Drilling, A., Cooksley, C., Chan, C., Wormald, P., & Vreugde, S. (2016). Fighting sinus-derived Staphylococcus aureus biofilms in vitro with a bacteriophage-derived muralytic enzyme. International Forum of Allergy and Rhinology, 6(4), 349-355.
Scopus20 WoS21 Europe PMC132016 Cleland, E., Bassiouni, A., Vreugde, S., & Wormald, P. (2016). The bacterial microbiome in chronic rhinosinusitis: Richness, diversity, postoperative changes, and patient outcomes. American Journal of Rhinology and Allergy, 30(1), 37-43.
Scopus47 WoS45 Europe PMC312016 Richter, K., Ramezanpour, M., Thomas, N., Prestidge, C., Wormald, P., & Vreugde, S. (2016). Mind “De GaPP”: in vitro efficacy of deferiprone and gallium-protoporphyrin against Staphylococcus aureus biofilms. International Forum of Allergy and Rhinology, 6(7), 737-743.
Scopus40 WoS37 Europe PMC232016 Ramezanpour, M., Moraitis, S., Smith, J., Wormald, P., & Vreugde, S. (2016). Th17 cytokines disrupt the airway mucosal barrier in chronic rhinosinusitis. Mediators of Inflammation, 2016, 9798206-1-9798206-7.
Scopus58 WoS49 Europe PMC262016 Miljkovic, D., Psaltis, A., Wormald, P., & Vreugde, S. (2016). T regulatory and Th17 cells in chronic rhinosinusitis with polyps. International Forum of Allergy and Rhinology, 6(8), 826-834.
Scopus17 WoS13 Europe PMC82016 Ou, J., Drilling, A., Singhal, D., Tan, N., Wallis-Hill, D., Vreugde, S., . . . Wormald, P. (2016). Association of intracellular Staphylococcus aureus with prognosis in chronic rhinosinusitis. International Forum of Allergy and Rhinology, 6(8), 792-799.
Scopus23 WoS22 Europe PMC172016 Ou, J., Drilling, A., Cooksley, C., Bassiouni, A., Kidd, S., Psaltis, A., . . . Vreugde, S. (2016). Reduced innate immune response to a Staphylococcus aureus small colony variant compared to its wild-type parent strain. Frontiers in Cellular and Infection Microbiology, 6(DEC), 187-1-187-9.
Scopus20 WoS21 Europe PMC142016 Hasan, S., Thomas, N., Thierry, B., Vreugde, S., Wormald, P., & Prestidge, C. (2016). Recent trends on the use of nanoparticles for nitric oxide delivery in antimicrobial applications. Drug Delivery Letters, 6(1), 3-10.
Scopus22015 Cantero, D., Cooksley, C., Bassiouni, A., Tran, H., Roscioli, E., Wormald, P., & Vreugde, S. (2015). Staphylococcus aureus biofilms induce apoptosis and expression of interferon-γ, interleukin-10, and interleukin-17A on human sinonasal explants. American Journal of Rhinology and Allergy, 29(1), 23-28.
Scopus14 WoS14 Europe PMC82015 Rajiv, S., Drilling, A., Bassiouni, A., James, C., Vreugde, S., & Wormald, P. (2015). Topical colloidal silver as an anti-biofilm agent in a Staphylococcus aureus chronic rhinosinusitis sheep model. International Forum of Allergy and Rhinology, 5(4), 283-288.
Scopus20 WoS18 Europe PMC112015 Malik, Z., Roscioli, E., Murphy, J., Ou, J., Bassiouni, A., Wormald, P., & Vreugde, S. (2015). Staphylococcus aureus impairs the airway epithelial barrier in vitro. International Forum of Allergy and Rhinology, 5(6), 551-556.
Scopus50 WoS45 Europe PMC292015 Bassiouni, A., Cleland, E., Psaltis, A., Vreugde, S., & Wormald, P. (2015). Sinonasal microbiome sampling: a comparison of techniques. PLoS One, 10(4), e0123216-1-e0123216-13.
Scopus42 WoS48 Europe PMC342015 Rajiv, S., Rodgers, S., Bassiouni, A., Vreugde, S., & Wormald, P. (2015). Role of crushed skeletal muscle extract in hemostasis. International Forum of Allergy & Rhinology, 5(5), 431-434.
Scopus4 WoS4 Europe PMC22015 Jardeleza, C., Thierry, B., Rao, S., Rajiv, S., Drilling, A., Miljkovic, D., . . . Wormald, P. (2015). An in vivo safety and efficacy demonstration of a topical liposomal nitric oxide donor treatment for Staphylococcus aureus biofilm-associated rhinosinusitis. Translational Research, 166(6), 683-692.
Scopus23 WoS22 Europe PMC122015 Dong, D., Thomas, N., Thierry, B., Vreugde, S., Prestidge, C., & Wormald, P. (2015). Distribution and Inhibition of liposomes on Staphylococcus aureus and Pseudomonas aeruginosa biofilm. PLoS One, 10(6), e0131806.
Scopus61 WoS59 Europe PMC292015 Thomas, N., Dong, D., Richter, K., Ramezanpour, M., Vreugde, S., Thierry, B., . . . Prestidge, C. (2015). Quatsomes for the treatment of Staphylococcus aureus biofilm. Journal of Materials Chemistry B, 3(14), 2770-2777.
Scopus24 WoS23 Europe PMC52015 Cooksley, C., Roscioli, E., Wormald, P., & Vreugde, S. (2015). TLR response pathways in NuLi-1 cells and primary human nasal epithelial cells. Molecular Immunology, 68(2 part B), 476-483.
Scopus19 WoS16 Europe PMC122014 Tan, N., Cooksley, C., Roscioli, E., Drilling, A., Douglas, R., Wormald, P., & Vreugde, S. (2014). Small-colony variants and phenotype switching of intracellular Staphylococcus aureus in chronic rhinosinusitis. Allergy, 69(10), 1364-1371.
Scopus34 WoS36 Europe PMC252014 Miljkovic, D., Bassiouni, A., Cooksley, C., Ou, J., Hauben, E., Wormald, P., & Vreugde, S. (2014). Association between group 2 innate lymphoid cells enrichment, nasal polyps and allergy in chronic rhinosinusitis. Allergy, 69(9), 1154-1161.
Scopus136 WoS126 Europe PMC962014 Padhye, V., Valentine, R., Paramasivan, S., Jardeleza, C., Bassiouni, A., Vreugde, S., & Wormald, P. (2014). Early and late complications of endoscopic hemostatic techniques following different carotid artery injury characteristics. International Forum of Allergy and Rhinology, 4(8), 651-657.
Scopus31 WoS29 Europe PMC192014 Cleland, E., Drilling, A., Bassiouni, A., James, C., Vreugde, S., & Wormald, P. (2014). Probiotic manipulation of the chronic rhinosinusitis microbiome. International Forum of Allergy and Rhinology, 4(4), 309-314.
Scopus42 WoS37 Europe PMC312014 Cleland, E., Bassioni, A., Boase, S., Dowd, S., Vreugde, S., & Wormald, P. (2014). The fungal microbiome in chronic rhinosinusitis: richness, diversity, postoperative changes and patient outcomes. International Forum of Allergy and Rhinology, 4(4), 259-265.
Scopus54 WoS51 Europe PMC382014 Drilling, A., Morales, S., Jardeleza, C., Vreugde, S., Speck, P., & Wormald, P. (2014). Bacteriophage reduces biofilm of Staphylococcus aureus ex vivo isolates from chronic rhinosinusitis patients. American Journal of Rhinology and Allergy, 28(1), 3-11.
Scopus50 WoS49 Europe PMC332014 Drilling, A., Coombs, G., Tan, H., Pearson, J., Boase, S., Psaltis, A., . . . Wormald, P. (2014). Cousins, siblings, or copies: the genomics of recurrent Staphylococcus aureus infections in chronic rhinosinusitis. International Forum of Allergy and Rhinology, 4(12), 953-960.
Scopus22 WoS19 Europe PMC142014 Jardeleza, C., Rao, S., Thierry, B., Gajjar, P., Vreugde, S., Prestidge, C., & Wormald, P. (2014). Liposome-encapsulated ISMN: a novel nitric oxide-based therapeutic agent against Staphylococcus aureus biofilms. PLoS One, 9(3), 1-9.
Scopus35 WoS31 Europe PMC132014 Drilling, A., Morales, S., Boase, S., Jervis-Bardy, J., James, C., Jardeleza, C., . . . Wormald, P. (2014). Safety and efficacy of topical bacteriophage and ethylenediaminetetraacetic acid treatment of Staphylococcus aureus infection in a sheep model of sinusitis. International Forum of Allergy & Rhinology, 4(3), 176-186.
Scopus52 WoS49 Europe PMC312014 Paramasivan, S., Drilling, A., Jardeleza, C., Jervis-Bardy, J., Vreugde, S., & Wormald, P. (2014). Methylglyoxal-augmented manuka honey as a topical anti-Staphylococcus aureus biofilm agent: safety and efficacy in an in vivo model. International Forum of Allergy & Rhinology, 4(3), 187-195.
Scopus50 WoS45 Europe PMC282014 Goggin, R., Jardeleza, C., Wormald, P., & Vreugde, S. (2014). Colloidal silver: a novel treatment for Staphylococcus aureus biofilms?. International Forum of Allergy & Rhinology, 4(3), 171-175.
Scopus27 WoS25 Europe PMC162014 Goggin, R., Jardeleza, C., Wormald, P., & Vreugde, S. (2014). Corticosteroids directly reduce Staphylococcus aureus biofilm growth: an in vitro study. The Laryngoscope, 124(3), 602-607.
Scopus22 WoS21 Europe PMC162014 Tan, N., Cooksley, C., Paramasivan, S., Vreugde, S., & Wormald, P. (2014). Safety evaluation of a sinus surfactant in an explant-based cytotoxicity assay. The Laryngoscope, 124(2), 369-372.
Scopus8 WoS6 Europe PMC32013 Jardeleza, C., Miljkovic, D., Baker, L., Boase, S., Tan, N., Koblar, S., . . . Vreugde, S. (2013). Inflammasome gene expression alterations in Staphylococcus aureus biofilm-associated chronic rhinosinusitis. Rhinology, 51(4), 315-322.
Scopus11 WoS11 Europe PMC82013 Cantero Cajas, D., Cooksley, C., Bassiouni, A., Wormald, P., & Vreugde, S. (2013). Staphylococcus aureus biofilm activates the nucleotide-binding oligomerization domain containing 2 (Nod2) pathway and proinflammatory factors on a human sinonasal explant model. International Forum of Allergy & Rhinology, 3(11), 877-884.
Scopus11 WoS10 Europe PMC82013 Cantero Cajas, D., Cooksley, C., Jardeleza, C., Bassiouni, A., Jones, D., Wormald, P., & Vreugde, S. (2013). A human nasal explant model to study Staphylococcus aureus biofilm in vitro. International Forum of Allergy & Rhinology, 3(7), 556-562.
Scopus14 WoS14 Europe PMC102013 Tan, N., Foreman, A., Jardeleza, C., Douglas, R., Vreugde, S., & Wormald, P. (2013). Intracellular Staphylococcus aureus: the Trojan horse of recalcitrant chronic rhinosinusitis?. International Forum of Allergy & Rhinology, 3(4), 261-266.
Scopus54 WoS49 Europe PMC382013 Jardeleza, C., Jones, D., Baker, L., Miljkovic, D., Boase, S., Tan, N., . . . Wormald, P. (2013). Gene expression differences in nitric oxide and reactive oxygen species regulation point to an altered innate immune response in chronic rhinosinusitis. International Forum of Allergy & Rhinology, 3(3), 193-198.
Scopus14 WoS13 Europe PMC102013 Jardeleza, C., Miljkovic, D., Baker, L., Boase, S., Tan, N. C. W., Koblar, S. A., . . . Vreugde, S. (2013). Inflammasome gene expression alterations in Staphylococcus aureus biofilm-associated chronic rhinosinusitis. Rhinology journal, 51(4), 315-322.
2012 Tan, N. W., Tran, H., Foreman, A., Jardeleza, C., Vreugde, S., & Wormald, P. J. (2012). Identifying intracellular Staphylococcus aureus in chronic rhinosinusitis: A direct comparison of techniques. American Journal of Rhinology & Allergy, 26(6), 444-449.
Scopus16 WoS16 Europe PMC122012 Tan, N. W., Tran, H., Roscioli, E., Wormald, P. J., & Vreugde, S. (2012). Prevention of false positive binding during immunofluorescence of Staphylococcus aureus infected tissue biopsies. Journal of Immunological Methods, 384(1-2), 111-117.
Scopus8 WoS8 Europe PMC52006 Vreugde, S., Ferrai, C., Miluzio, A., Hauben, E., Marchisio, P., Crippa, M., . . . Biffo, S. (2006). Nuclear myosin VI enhances RNA polymerase II-dependent transcription. Molecular Cell, 23(5), 749-755.
Scopus112 WoS104 Europe PMC852006 Friedmann, E., Hauben, E., Maylandt, K., Schleeger, S., Vreugde, S., Lichtenthaler, S., . . . Martoglio, B. (2006). SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. Nature Cell Biology, 8(8), 849-854.
2006 Friedmann, E., Hauben, E., Maylandt, K., Schleeger, S., Vreugde, S., Lichtenthaler, S. F., . . . Martoglio, B. (2006). SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production. Nature Cell Biology, 8(8), 843-848.
Scopus166 WoS160 Europe PMC1262002 Vreugde, S., Erven, A., Kros, C. J., Marcotti, W., Fuchs, H., Kurima, K., . . . Steel, K. P. (2002). Beethoven, a mouse model for dominant, progressive hearing loss DFNA36. Nature Genetics, 30(3), 257-258.
Scopus211 WoS199 Europe PMC1642002 Walsh, T., Walsh, V., Vreugde, S., Hertzano, R., Shahin, H., Haika, S., . . . Avraham, K. B. (2002). From flies' eyes to our ears: Mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30. Proceedings of the National Academy of Sciences of the United States of America, 99(11), 7518-7523.
Scopus188 WoS172 Europe PMC1412002 Adato, A., Vreugde, S., Joensuu, T., Avidan, N., Hamalainen, R., Belenkiy, O., . . . Lancet, D. (2002). USH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses. European Journal of Human Genetics, 10(6), 339-350.
Scopus139 WoS128 Europe PMC1062000 Frydman, M., Vreugde, S., Nageris, B. I., Weiss, S., Vahava, O., & Avraham, K. B. (2000). Clinical characterization of genetic hearing loss caused by a mutation in the POU4F3 transcription factor. Archives of Otolaryngology - Head and Neck Surgery, 126(5), 633-637.
Scopus24 WoS20 Europe PMC152000 Sobe, T., Vreugde, S., Shahin, H., Berlin, M., Davis, N., Kanaan, M., . . . Avraham, K. (2000). The prevalence and expression of inherited connexin 26 mutations associated with nonsyndromic hearing loss in the Israeli population. Human Genetics, 106(1), 50-57.
Scopus139 WoS122 Europe PMC991999 Sobe, T., Erlich, P., Berry, A., Korostichevsky, M., Vreugde, S., Avraham, K. B., . . . Shohat, M. (1999). High frequency of the deafness-associated 167delT mutation in the connexin 26 (GJB2) gene in Israeli Ashkenazim [2]. American Journal of Medical Genetics, 86(5), 499-500.
Scopus59 WoS55 Europe PMC381999 Vreugde, S., Duttmann, R., Halama, A., & Deron, P. (1999). Metastasis of a renal cell carcinoma to the nose and paranasal sinuses. Acta Oto-Rhino-Laryngologica Belgica, 53(2), 129-131.
Scopus9 Europe PMC71997 De Maeseneer, M., Vreugde, S., Laureys, S., Sartoris, D. J., De Ridder, F., & Osteaux, M. (1997). Calcific tendinitis of the longus colli muscle. Head and Neck, 19(6), 545-548.
Scopus51 WoS37 Europe PMC261994 Vreugde, S. (1994). Nutritional aspects of dysphagia.. Acta oto-rhino-laryngologica Belgica, 48(2), 229-234.
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Conference Items
Year Citation 2016 Lau, A. H. Y., Lester, S., Moraitis, S., Ou, J., Rischmueller, M., Wormald, P. J., & Vreugde, S. (2016). Tertiary Lymphoid Organ in Chronic Rhinosinusitis. Poster session presented at the meeting of 2016 ASMR South Australian Scientific Meeting. Convention Centre, Adelaide, South Australia, Australia.
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 Co-Supervisor Target the tumour microbiome to improve head & neck cancer treatment outcomes Doctor of Philosophy Doctorate Full Time Mrs Lee Mai 2023 Co-Supervisor Microbiological and immunological interactions in the pathogenesis of fungal chronic rhinosinustis Doctor of Philosophy Doctorate Full Time Dr James Thomas Connell 2023 Co-Supervisor Non-steroid based novel treatment options for chronic rhinosinusitis Doctor of Philosophy Doctorate Full Time Mr William Mark Murphy 2023 Principal Supervisor Direct Interaction between Virus and Bacteria Facilitating Chronic bacterial Rhinosinusitis Doctor of Philosophy Doctorate Full Time Ms Urmi Bhattacharjee 2023 Principal Supervisor Exploring The Efficacy Of Bacteriophage Therapy In Disrupting Poly-Microbial Biofilms In Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Mr Xiaohan Sun 2023 Co-Supervisor Eradicating S. Aureus infection with a novel bacteriophage cocktail in chronic rhinosinusitis and exploring its impact on the sinonasal microbiome: a double-blinded, randomised controlled trial. Master of Philosophy (Surgery) Master Full Time Miss Isabella Amy Burdon 2023 Principal Supervisor Potential use of essential oils from ethno-medicinal plants in clinical research Doctor of Philosophy Doctorate Full Time Miss Sumeena Karki 2023 Principal Supervisor Investigating Phage, Microbe and Host Interactions by Integrating Systems Multiomics Doctor of Philosophy Doctorate Full Time Mr George Spyro Bouras 2023 Co-Supervisor Investigating the potential synergistic activity between bacteriophage loaded hydrogels and blue light as a treatment paradigm for infected chronic wounds Doctor of Philosophy Doctorate Full Time Mr Abdul Ali Abbas 2022 Principal Supervisor The role of various Staphylococcus species in eliciting inflammation in Chronic rhinosinusitis Doctor of Philosophy Doctorate Full Time Mr Sintayehu Ambachew Wondemagegn 2021 Principal Supervisor The Interplay Between Tumour-associated Microbiota, Tertiary Lymphoid Organ Development and Oral Cancer Carcinogenesis Doctor of Philosophy Doctorate Full Time Mr Kenny Ker Li Yeo 2021 Co-Supervisor Determining the safety and efficacy of novel beta-chitin patch in managing cerebral (low-flow, low-pressure) and carotid (high-flow, high-pressure) bleeding Doctor of Philosophy Doctorate Full Time Dr Annika Reann Mascarenhas 2019 Principal Supervisor ROLE OF PROPHAGES IN Staphylococcus aureus VIRULENCE AND PATHOGENICITY Doctor of Philosophy Doctorate Full Time Mr Roshan Nepal -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2021 - 2023 Co-Supervisor Investigating Transcription Factors in the Human Airway Mucosal Immunoepigenetics of Chronic Inflammatory Disease Master of Philosophy (Surgery) Master Full Time Mr Harrison Burchill Bolt 2020 - 2023 Co-Supervisor Topical Therapies for The Management of Recalcitrant Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Dr Anna Katharina Megow 2020 - 2022 Co-Supervisor The Relationship Between S. Aureus Biofilm Properties, Inflammation, and Disease Severity in Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Mrs Gohar Shaghayegh 2019 - 2023 Principal Supervisor The Adaption and Inflammation-Inducing Capacity of Staphylococcus Aureus in Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Mr Ghais Houtak 2018 - 2022 Principal Supervisor Investigating Microbiome - Targeted Treatments for Chronic Rhinosinusitis: A novel approach to combat dysbiosis in the nasal microbiome Doctor of Philosophy Doctorate Full Time Mrs Martha Menberu 2018 - 2022 Principal Supervisor The Role of Colloidal Silver Synthesized from Corymbia Maculata in Eradicating Infection in Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Miss Sholeh Feizi 2018 - 2020 Principal Supervisor The role of viruses in chronic rhinosinusitis Doctor of Philosophy Doctorate Full Time Dr Rachel Katherine Goggin 2018 - 2021 Co-Supervisor Modifying Post-Surgical Wound Healing Doctor of Philosophy Doctorate Full Time Rajan Vediappan 2018 - 2020 Principal Supervisor The Host-Microbe Interface in Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Mr Sathish Paramasivan 2017 - 2020 Co-Supervisor Bacteriophage Therapy for Chronic Rhinosinusitis: Targeting Pseudomonas Aeruginosa Biofilms Doctor of Philosophy Doctorate Full Time Miss Stephanie Anne Fong 2017 - 2020 Co-Supervisor Staphylococcus aureus Exoproteins on Nasal Epithelial Barrier in Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Dr Beula Subashini Panchatcharam 2017 - 2020 Co-Supervisor Novel Topical Anti-biofilm Agents in the Treatment of Recalcitrant Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Miss Mian Li Ooi 2016 - 2017 Co-Supervisor The microbiome of otitis media with effusion and the influence of Alloicoccus otitidis on Haemophilus influenzae in polymicrobial biofilm Doctor of Philosophy Doctorate Full Time Dr Chun Chan 2016 - 2019 Co-Supervisor Corticosteroids and the Sinonasal Microbiome Doctor of Philosophy Doctorate Full Time Dr Lisa Mary Cherian 2015 - 2018 Co-Supervisor The Mucosal Barrier in Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Mr Jae Viktor Murphy 2015 - 2018 Principal Supervisor An Immunological Perspective of the Mucosal Inflammation in Chronic Rhinosinusitis – Lymphoid Neo-organogenesis and Humoral Immunity Doctor of Philosophy Doctorate Full Time Mr Aden Lau 2014 - 2017 Principal Supervisor Towards Novel Antibiofilm Strategies Doctor of Philosophy Doctorate Full Time Dr Katharina Richter 2014 - 2017 Co-Supervisor The Role of Immune Cells in Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Ms Dijana Miljkovic 2013 - 2015 Co-Supervisor Management of Major Vessel Haemorrhage in Endonasal Surgery Doctor of Philosophy Doctorate Full Time Vikram Padhye 2012 - 2014 Co-Supervisor The Chronic Rhinosinusitis Microbiome Doctor of Philosophy Doctorate Full Time Dr Edward John Cleland 2012 - 2015 Co-Supervisor The Effect of Chitosan Dextran Gel as a Haemostatic and Anti Adhesion Agent in the Central Nervous System and Evaluation of Haemostatic Mechanism of Skeletal Muscle Tissue Doctor of Philosophy Doctorate Full Time Dr Sukanya Rajiv 2012 - 2015 Co-Supervisor The Role of Surgery and Disease Load in Refractory Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Mr Ahmed Bassiouni 2012 - 2013 Co-Supervisor Intracellular Staphylococcus aureus in chronic rhinosinusitis Doctor of Philosophy Doctorate Full Time Dr Neil Cheng-Wen Tan 2012 - 2014 Co-Supervisor The innate immune response to Staphylococcus aureus biofilms on human sinonasal explants Doctor of Philosophy Doctorate Full Time Mr Daniel Anibal Cantero Cajas 2012 - 2014 Co-Supervisor Nitric Oxide and Staphylococcus aureus Biofilms: Defining their Intricate Relationship in Chronic Rhinosinusitis Doctor of Philosophy Doctorate Part Time Dr Camille Jardeleza
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Committee Memberships
Date Role Committee Institution Country 2019 - ongoing Chair BHI Strategic Research Directions Committee Basil Hetzel Institute Australia 2016 - ongoing Member TQEH Human Research Ethics Committee - - 2014 - ongoing Member The Basil Hetzel Institute Management Committee The Bsil Hetzel Institute Australia 2011 - ongoing Chair Selection committee for scientist positions - - -
Memberships
Date Role Membership Country 2017 - ongoing Member American Society of Microbiology - -
Editorial Boards
Date Role Editorial Board Name Institution Country 2018 - ongoing Associate Editor Frontiers in Cellular and Infection Microbiology Frontiers Journals United Kingdom 2016 - ongoing Associate Editor Sinusitis - -
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