Associate Professor Sarah Vreugde
Senior Scientist
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD, but is currently at capacity - email supervisor to discuss availability.
Associate Professor Sarah Vreugde
Senior Scientist Group: ENT Surgery
The Department of Otolaryngology, Head and Neck Surgery at The Queen Elizabeth Hospital is committed to excellence in translational research and education. Research in our department is focused mainly on understanding the pathogenesis of chronic rhinosinusitis (CRS), using a multidisciplinary approach, aimed at identifying new diagnostic/prognostic markers and treatment strategies to the benefit of our patients. Research projects cover all aspects of rhinological research from pathophysiological aspects of CRS to the identification and validation of new treatment strategies in vitro and in vivo, bringing research from bench to bedside.
Our Department of ENT has an excellent track record of Honours and Higher degree supervision with a 100% completion rate. Professor PJ Wormald was recognized for “Excellence in Research Supervision” by The University of Adelaide in 2013. We are always interested in students that have exceptional motivation and are passionate about research and in return we provide them with full support in terms of research supervision direction.
Projects in my laboratory are focused on diseases of the ear, nose and throat. In particular, my research is focused on pathophysiological aspects of chronic rhinosinusitis, aimed at the identification and validation of new diagnostic and treatment strategies in vitro and in vivo. Projects range from defining molecular mechanisms and microbial determinants of chronic inflammation to the validation of anti-bacterial and wound-healing compounds in vitro and in vivo.
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Appointments
Date Position Institution name 2017 Associate Professor The University of Adelaide 2013 - 2016 Senior Scientist The University of Adelaide 2008 - 2011 Patent Examiner European Patent Office 2003 - 2006 Post-doctoral research scientist Istituto Scientifico San Raffaele (IRCCS), Milan 2003 - 2006 Consultant San Raffaele Hospital, Milan -
Language Competencies
Language Competency Dutch; Flemish Can read, write, speak, understand spoken and peer review English Can read, write, speak, understand spoken and peer review French Can read, write, speak, understand spoken and peer review German Can read, speak and understand spoken Hebrew Can speak and understand spoken Italian Can read, write, speak, understand spoken and peer review -
Education
Date Institution name Country Title 1998 - 2002 Tel Aviv University Israel PhD 1994 - 2000 Free University Brussels Belgium ENT Specialisation 1994 Free University Brussels Belgium MD -
Research Interests
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Journals
Year Citation 2019 Murphy, J., Ramezanpour, M., Drilling, A., Roscioli, E., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2019). In vitro characteristics of an airway barrier-disrupting factor secreted by Staphylococcus aureus. International Forum of Allergy and Rhinology, 9(2), 187-196.
Scopus1 WoS12019 Fong, S., Drilling, A., Ooi, M., Paramasivan, S., Finnie, J., Morales, S., . . . Wormald, P. (2019). Safety and efficacy of a bacteriophage cocktail in an in vivo model of Pseudomonas aeruginosa sinusitis. Translational Research, 206, 41-56.
Scopus1 WoS12019 Ramezanpour, M., Bolt, H., Psaltis, A., Wormald, P., & Vreugde, S. (2019). Inducing a Mucosal Barrier–Sparing Inflammatory Response in Laboratory-Grown Primary Human Nasal Epithelial Cells. Current Protocols in Toxicology, 80(1), e69.
Scopus12019 Cherian, L., Cooksley, C., Richter, K., Ramezanpour, M., Paramasivan, S., Wormald, P., . . . Psaltis, A. (2019). Effect of commercial nasal steroid preparation on bacterial growth. International Forum of Allergy and Rhinology, 9(7), 766-775.
2019 Ramezanpour, M., Smith, J., Ooi, M., Gouzos, M., Psaltis, A., Wormald, P., & Vreugde, S. (2019). Deferiprone has anti-inflammatory properties and reduces fibroblast migration in vitro. Scientific Reports, 9(1), 9 pages.
2019 Li, J., Ramezanpour, M., Fong, S., Cooksley, C., Murphy, J., Suzuki, M., . . . Vreugde, S. (2019). Pseudomonas aeruginosa exoprotein-induced barrier disruption correlates with elastase activity and marks Chronic Rhinosinusitis severity. Frontiers in Cellular and Infection Microbiology, 9, 38.
Scopus2 WoS22019 Goggin, R., Bennett, C., Bialasiewicz, S., Vediappan, R., Vreugde, S., Wormald, P., & Psaltis, A. (2019). The presence of virus significantly associates with chronic rhinosinusitis disease severity. Allergy: European Journal of Allergy and Clinical Immunology, 74(8), 1569-1572.
Scopus12019 Bennett, C., Ramezanpour, M., Cooksley, C., Vreugde, S., & Psaltis, A. (2019). Kappa-carrageenan sinus rinses reduce inflammation and intracellular Staphylococcus aureus infection in airway epithelial cells. International Forum of Allergy and Rhinology, 9(8), 918-925.
2019 Kao, S., Ramezanpour, M., Bassiouni, A., Finnie, J., Wormald, P., Vreugde, S., & Psaltis, A. (2019). Barrier disruptive effects of mucus isolated from chronic rhinosinusitis patients. Allergy: European Journal of Allergy and Clinical Immunology, 3 pages.
2019 Ooi, M., Drilling, A., Morales, S., Fong, S., Moraitis, S., MacIas-Valle, L., . . . Wormald, P. (2019). Safety and tolerability of bacteriophage therapy for chronic rhinosinusitis due to staphylococcus aureus. JAMA Otolaryngology - Head and Neck Surgery, 145(8), 723-729.
Scopus2 WoS12019 Govindaraju, R., Cherian, L., Macias-Valle, L., Murphy, J., Gouzos, M., Vreugde, S., . . . Psaltis, A. J. (2019). Extent of maxillary sinus surgery and its effect on instrument access, irrigation penetration, and disease clearance. INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY, 9(10), 1097-1104.
2019 Kao, S., Ramezanpour, M., Bassiouni, A., Wormald, P., Psaltis, A., & Vreugde, S. (2019). The effect of neutrophil serine proteases on human nasal epithelial cell barrier function. International Forum of Allergy and Rhinology, 9(10), 7 pages.
Scopus1 WoS12019 Ooi, M., Jothin, A., Bennett, C., Ooi, E., Vreugde, S., Psaltis, A., & Wormald, P. (2019). Manuka honey sinus irrigations in recalcitrant chronic rhinosinusitis: phase 1 randomized, single-blinded, placebo-controlled trial. International Forum of Allergy and Rhinology, 8 pages.
2019 Hu, H., Ramezanpour, M., Hayes, A. J., Liu, S., Psaltis, A. J., Wormald, P., & Vreugde, S. (2019). Sub-Inhibitory Clindamycin and Azithromycin reduce S. aureus Exoprotein Induced Toxicity, Inflammation, Barrier Disruption and Invasion.. Journal of clinical medicine, 8(10).
2018 Murphy, J., Ramezanpour, M., Stach, N., Dubin, G., Psaltis, A., Wormald, P., & Vreugde, S. (2018). Staphylococcus Aureus V8 protease disrupts the integrity of the airway epithelial barrier and impairs IL-6 production in vitro. Laryngoscope, 128(1), 8-15.
Scopus10 WoS9 Europe PMC42018 Zhang, G., Zhao, Y., Paramasivan, S., Richter, K., Morales, S., Wormald, P., & Vreugde, S. (2018). Bacteriophage effectively kills multidrug resistant Staphylococcus aureus clinical isolates from chronic rhinosinusitis patients. International Forum of Allergy and Rhinology, 8(3), 406-414.
Scopus9 WoS7 Europe PMC42018 Ooi, M., Richter, K., Bennett, C., Macias-Valle, L., Vreugde, S., Psaltis, A., & Wormald, P. (2018). Topical colloidal silver for the treatment of recalcitrant chronic rhinosinusitis. Frontiers in Microbiology, 9(APR), 1-7.
Scopus2 WoS2 Europe PMC12018 Ooi, M., Richter, K., Drilling, A., Thomas, N., Prestidge, C., James, C., . . . Wormald, P. (2018). Safety and efficacy of topical chitogel- deferiprone- gallium protoporphyrin in a sheep sinusitis model. Frontiers in Microbiology, 9(MAY), 9 pages.
Scopus3 WoS3 Europe PMC12018 Suzuki, M., Ramezanpour, M., Cooksley, C., Li, J., Nakamaru, Y., Homma, A., . . . Vreugde, S. (2018). Sirtuin-1 Controls Poly (I:C)-Dependent Matrix Metalloproteinase 9 Activation in Primary Human Nasal Epithelial Cells. American journal of respiratory cell and molecular biology, 59(4), 500-510.
Scopus1 WoS1 Europe PMC12018 Murphy, J., Ramezanpour, M., Roscioli, E., Psaltis, A., Wormald, P., & Vreugde, S. (2018). Mucosal zinc deficiency in chronic rhinosinusitis with nasal polyposis contributes to barrier disruption and decreases ZO-1. Allergy: European Journal of Allergy and Clinical Immunology, 73(10), 2095-2097.
Scopus4 WoS32018 Zhao, Y., Bassiouni, A., Tanjararak, K., Vreugde, S., Wormald, P., & Psaltis, A. (2018). Role of fungi in chronic rhinosinusitis through ITS sequencing. Laryngoscope, 128(1), 16-22.
Scopus6 WoS6 Europe PMC62018 Ramezanpour, M., Bolt, H., Psaltis, A., Wormald, P., & Vreugde, S. (2018). Primary human nasal epithelial cells: a source of poly (I:C) LMW-induced IL-6 production. Scientific Reports, 8(1), 8 pages.
Scopus5 WoS2 Europe PMC12018 Zhang, G., Zhao, Y., Hayes, A., Psaltis, A., Wormald, P., & Vreugde, S. (2018). Staphylococcus aureus small colony variants: Prevalence in chronic rhinosinusitis and induction by antibiotics. Allergy: European Journal of Allergy and Clinical Immunology, 73(12), 2403-2405.
Scopus1 WoS12018 Paramasivan, S., Lester, S., Lau, A., Ou, J., Psaltis, A., Wormald, P., & Vreugde, S. (2018). Tertiary lymphoid organs: A novel target in patients with chronic rhinosinusitis. Journal of Allergy and Clinical Immunology, 142(5), 1673-1676.
2018 Goggin, R., Bennett, C., Bassiouni, A., Bialasiewicz, S., Vreugde, S., Wormald, P., & Psaltis, A. (2018). Comparative viral sampling in the sinonasal passages; Different viruses at different sites. Frontiers in Cellular and Infection Microbiology, 8(SEP), 8 pages.
Scopus1 WoS12018 Bardy, J., Sarovich, D., Price, E., Steinig, E., Tong, S., Drilling, A., . . . Psaltis, A. (2018). Staphylococcus aureus from patients with chronic rhinosinusitis show minimal genetic association between polyp and non-polyp phenotypes 06 Biological Sciences 0604 Genetics. BMC Ear, Nose and Throat Disorders, 18(1).
2018 Miljkovic, D., Psaltis, A., Wormald, P., & Vreugde, S. (2018). Naive and effector B-cell subtypes are increased in chronic rhinosinusitis with polyps. American Journal of Rhinology and Allergy, 32(1), 3-6.
2017 Ou, J., Bassiouni, A., Drilling, A., Psaltis, A., Vreugde, S., & Wormald, P. (2017). The persistence of intracellular Staphylococcus aureus in the sinuses: a longitudinal study.. Rhinology, 55(4), 305-311.
Scopus4 WoS4 Europe PMC22017 Ramezanpour, M., Rayan, A., Smith, J., & Vreugde, S. (2017). The effect of topical treatments for CRS on the sinonasal epithelial barrier. Rhinology, 55(2), 161-169.
Scopus5 Europe PMC22017 Chan, C., Richter, K., Wormald, P., Psaltis, A., & Vreugde, S. (2017). Alloiococcus otitidis forms multispecies biofilm with Haemophilus influenzae: effects on antibiotic susceptibility and Growth in Adverse Conditions. Frontiers in Cellular and Infection Microbiology, 7(AUG), 344-1-344-9.
Scopus5 WoS5 Europe PMC32017 Oue, S., Ramezanpour, M., Paramasivan, S., Miljkovic, D., Cooksley, C., Bassiouni, A., . . . Vreugde, S. (2017). Increased IL-13 expression is independently associated with neo-osteogenesis in patients with chronic rhinosinusitis. Journal of Allergy and Clinical Immunology, 140(5), 1444-1448.e11.
Scopus2 WoS2 Europe PMC22017 Richter, K., Facal, P., Thomas, N., Vandecandelaere, I., Ramezanpour, M., Cooksley, C., . . . Vreugde, S. (2017). Taking the silver bullet colloidal silver particles for the topical treatment of biofilm-related infections. ACS Applied Materials and Interfaces, 9(26), 21631-21638.
Scopus10 WoS9 Europe PMC32017 Richter, K., Thomas, N., Zhang, G., Prestidge, C., Coenye, T., Wormald, P. -J., & Vreugde, S. (2017). Deferiprone and gallium-protoporphyrin have the capacity to potentiate the activity of antibiotics in Staphylococcus aureus small colony variants. Frontiers in Cellular and Infection Microbiology, 7(JUN), 280-1-280-10.
Scopus8 WoS9 Europe PMC72017 Jukes, A., Murphy, J., Vreugde, S., Psaltis, A., & Wormald, P. (2017). Nano-hemostats and a Pilot Study of Their Use in a Large Animal Model of Major Vessel Hemorrhage in Endoscopic Skull Base Surgery. Journal of Neurological Surgery, Part B: Skull Base, 78(3), 215-221.
Europe PMC12017 Miljkovic, D., Ou, J., Kirana, C., Hulse, K., Hauben, E., Psaltis, A., . . . Vreugde, S. (2017). Discordant frequencies of tissue-resident and circulating CD180-negative B cells in chronic rhinosinusitis. International Forum of Allergy and Rhinology, 7(6), 609-614.
Scopus2 WoS2 Europe PMC12017 Drilling, A., Ooi, M., Miljkovic, D., James, C., Speck, P., Vreugde, S., . . . Wormald, P. (2017). Long-term safety of topical bacteriophage application to the frontal sinus region. Frontiers in Cellular and Infection Microbiology, 7(FEB), 1-8.
Scopus13 WoS12 Europe PMC72017 Chan, C., Wabnitz, D., Bassiouni, A., Wormald, P., Vreugde, S., & Psaltis, A. (2017). Identification of the bacterial reservoirs for the middle ear using phylogenic analysis. JAMA Otolaryngology - Head and Neck Surgery, 143(2), 155-161.
Scopus10 WoS10 Europe PMC52017 Richter, K., Thomas, N., Claeys, J., McGuane, J., Prestidge, C., Coenye, T., . . . Vreugde, S. (2017). A topical hydrogel with deferiprone and gallium-protoporphyrin targets bacterial iron metabolism and has antibiofilm activity. Antimicrobial Agents and Chemotherapy, 61(6), e00481-17-1-e00481-17-11.
Scopus12 WoS14 Europe PMC52017 Miljkovic, D., Psaltis, A., Wormald, P., & Vreugde, S. (2017). Chronic rhinosinusitis with polyps is characterized by increased mucosal and blood Th17 effector cytokine producing cells. Frontiers in Physiology, 8(DEC), 7 pages.
Scopus3 WoS3 Europe PMC32017 Fong, S., Drilling, A., Morales, S., Cornet, M., Woodworth, B., Fokkens, W., . . . Wormald, P. (2017). Activity of bacteriophages in removing biofilms of pseudomonas aeruginosa isolates from chronic rhinosinusitis patients. Frontiers in Cellular and Infection Microbiology, 7(SEP), 1-11.
Scopus25 Europe PMC142017 Ramezanpour, M., Murphy, J., Smith, J., Vreugde, S., & Psaltis, A. (2017). In vitro safety evaluation of human nasal epithelial cell monolayers exposed to carrageenan sinus wash. International Forum of Allergy and Rhinology, 7(12), 1170-1177.
Scopus7 WoS5 Europe PMC12017 Lau, A., Lester, S., Moraitis, S., Ou, J., Psaltis, A., McColl, S., . . . Vreugde, S. (2017). Tertiary lymphoid organs in recalcitrant chronic rhinosinusitis. Journal of Allergy and Clinical Immunology, 139(4), 1371-1373.
Scopus5 WoS4 Europe PMC22016 Ou, J., Drilling, A., Cooksley, C., Bassiouni, A., Kidd, S., Psaltis, A., . . . Vreugde, S. (2016). Reduced innate immune response to a Staphylococcus aureus small colony variant compared to its wild-type parent strain. Frontiers in Cellular and Infection Microbiology, 6(DEC), 187-1-187-9.
Scopus9 WoS9 Europe PMC72016 Ou, J., Drilling, A., Singhal, D., Tan, N., Wallis-Hill, D., Vreugde, S., . . . Wormald, P. (2016). Association of intracellular Staphylococcus aureus with prognosis in chronic rhinosinusitis. International Forum of Allergy and Rhinology, 6(8), 792-799.
Scopus12 WoS12 Europe PMC72016 Chan, C., Wabnitz, D., Bardy, J., Bassiouni, A., Wormald, P., Vreugde, S., & Psaltis, A. (2016). The microbiome of otitis media with effusion. Laryngoscope, 126(12), 2844-2851.
Scopus20 WoS19 Europe PMC132016 Bassiouni, A., Ou, J., Rajiv, S., Cantero, D., Vreugde, S., & Wormald, P. (2016). Subepithelial inflammatory load and basement membrane thickening in refractory chronic rhinosinusitis with nasal polyposis: A histopathological study. International Forum of Allergy and Rhinology, 6(3), 248-255.
Scopus12 WoS11 Europe PMC82016 Vreugde, S., & Wormald, P. (2016). Innate lymphoid type 2 cells in chronic rhinosinusitis. Current Opinion in Allergy and Clinical Immunology, 16(1), 7-12.
Scopus4 WoS3 Europe PMC22016 Cleland, E., Bassiouni, A., Vreugde, S., & Wormald, P. (2016). The bacterial microbiome in chronic rhinosinusitis: Richness, diversity, postoperative changes, and patient outcomes. American Journal of Rhinology and Allergy, 30(1), 37-43.
Scopus19 WoS20 Europe PMC172016 Miljkovic, D., Psaltis, A., Wormald, P., & Vreugde, S. (2016). T regulatory and Th17 cells in chronic rhinosinusitis with polyps. International Forum of Allergy and Rhinology, 6(8), 826-834.
Scopus8 WoS6 Europe PMC52016 Ramezanpour, M., Moraitis, S., Smith, J., Wormald, P., & Vreugde, S. (2016). Th17 cytokines disrupt the airway mucosal barrier in chronic rhinosinusitis. Mediators of Inflammation, 2016, 9798206-1-9798206-7.
Scopus24 WoS22 Europe PMC122016 Richter, K., Ramezanpour, M., Thomas, N., Prestidge, C., Wormald, P., & Vreugde, S. (2016). Mind “De GaPP”: in vitro efficacy of deferiprone and gallium-protoporphyrin against Staphylococcus aureus biofilms. International Forum of Allergy and Rhinology, 6(7), 737-743.
Scopus15 WoS13 Europe PMC72016 Drilling, A., Cooksley, C., Chan, C., Wormald, P., & Vreugde, S. (2016). Fighting sinus-derived Staphylococcus aureus biofilms in vitro with a bacteriophage-derived muralytic enzyme. International Forum of Allergy and Rhinology, 6(4), 349-355.
Scopus14 WoS13 Europe PMC92016 Hasan, S., Thomas, N., Thierry, B., Vreugde, S., Wormald, P., & Prestidge, C. (2016). Recent trends on the use of nanoparticles for nitric oxide delivery in antimicrobial applications. Drug Delivery Letters, 6(1), 3-10.
Scopus22015 Jardeleza, C., Thierry, B., Rao, S., Rajiv, S., Drilling, A., Miljkovic, D., . . . Wormald, P. (2015). An in vivo safety and efficacy demonstration of a topical liposomal nitric oxide donor treatment for Staphylococcus aureus biofilm-associated rhinosinusitis. Translational Research, 166(6), 683-692.
Scopus8 WoS9 Europe PMC72015 Rajiv, S., Drilling, A., Bassiouni, A., James, C., Vreugde, S., & Wormald, P. (2015). Topical colloidal silver as an anti-biofilm agent in a Staphylococcus aureus chronic rhinosinusitis sheep model. International Forum of Allergy and Rhinology, 5(4), 283-288.
Scopus10 WoS11 Europe PMC92015 Rajiv, S., Rodgers, S., Bassiouni, A., Vreugde, S., & Wormald, P. (2015). Role of crushed skeletal muscle extract in hemostasis. International Forum of Allergy & Rhinology, 5(5), 431-434.
Scopus2 WoS2 Europe PMC22015 Malik, Z., Roscioli, E., Murphy, J., Ou, J., Bassiouni, A., Wormald, P., & Vreugde, S. (2015). Staphylococcus aureus impairs the airway epithelial barrier in vitro. International Forum of Allergy and Rhinology, 5(6), 551-556.
Scopus25 WoS26 Europe PMC162015 Cooksley, C., Roscioli, E., Wormald, P., & Vreugde, S. (2015). TLR response pathways in NuLi-1 cells and primary human nasal epithelial cells. Molecular Immunology, 68(2 part B), 476-483.
Scopus8 WoS7 Europe PMC62015 Bassiouni, A., Cleland, E., Psaltis, A., Vreugde, S., & Wormald, P. (2015). Sinonasal microbiome sampling: a comparison of techniques. PLoS One, 10(4), e0123216-1-e0123216-13.
Scopus23 WoS28 Europe PMC232015 Cantero, D., Cooksley, C., Bassiouni, A., Tran, H., Roscioli, E., Wormald, P., & Vreugde, S. (2015). Staphylococcus aureus biofilms induce apoptosis and expression of interferon-γ, interleukin-10, and interleukin-17A on human sinonasal explants. American Journal of Rhinology and Allergy, 29(1), 23-28.
Scopus8 WoS8 Europe PMC52015 Dong, D., Thomas, N., Thierry, B., Vreugde, S., Prestidge, C., & Wormald, P. (2015). Distribution and Inhibition of liposomes on Staphylococcus aureus and Pseudomonas aeruginosa biofilm. PLoS One, 10(6), e0131806.
Scopus21 WoS21 Europe PMC112015 Thomas, N., Dong, D., Richter, K., Ramezanpour, M., Vreugde, S., Thierry, B., . . . Prestidge, C. (2015). Quatsomes for the treatment of Staphylococcus aureus biofilm. Journal of Materials Chemistry B, 3(14), 2770-2777.
Scopus12 WoS112014 Miljkovic, D., Bassiouni, A., Cooksley, C., Ou, J., Hauben, E., Wormald, P., & Vreugde, S. (2014). Association between group 2 innate lymphoid cells enrichment, nasal polyps and allergy in chronic rhinosinusitis. Allergy, 69(9), 1154-1161.
Scopus92 WoS86 Europe PMC712014 Cleland, E., Drilling, A., Bassiouni, A., James, C., Vreugde, S., & Wormald, P. (2014). Probiotic manipulation of the chronic rhinosinusitis microbiome. International Forum of Allergy and Rhinology, 4(4), 309-314.
Scopus19 WoS21 Europe PMC182014 Padhye, V., Valentine, R., Paramasivan, S., Jardeleza, C., Bassiouni, A., Vreugde, S., & Wormald, P. (2014). Early and late complications of endoscopic hemostatic techniques following different carotid artery injury characteristics. International Forum of Allergy and Rhinology, 4(8), 651-657.
Scopus17 WoS16 Europe PMC122014 Cleland, E., Bassioni, A., Boase, S., Dowd, S., Vreugde, S., & Wormald, P. (2014). The fungal microbiome in chronic rhinosinusitis: richness, diversity, postoperative changes and patient outcomes. International Forum of Allergy and Rhinology, 4(4), 259-265.
Scopus31 WoS31 Europe PMC262014 Drilling, A., Coombs, G., Tan, H., Pearson, J., Boase, S., Psaltis, A., . . . Wormald, P. (2014). Cousins, siblings, or copies: the genomics of recurrent Staphylococcus aureus infections in chronic rhinosinusitis. International Forum of Allergy and Rhinology, 4(12), 953-960.
Scopus12 WoS10 Europe PMC92014 Tan, N., Cooksley, C., Paramasivan, S., Vreugde, S., & Wormald, P. (2014). Safety evaluation of a sinus surfactant in an explant-based cytotoxicity assay. The Laryngoscope, 124(2), 369-372.
Scopus6 WoS5 Europe PMC32014 Tan, N., Cooksley, C., Roscioli, E., Drilling, A., Douglas, R., Wormald, P., & Vreugde, S. (2014). Small-colony variants and phenotype switching of intracellular Staphylococcus aureus in chronic rhinosinusitis. Allergy, 69(10), 1364-1371.
Scopus23 WoS23 Europe PMC192014 Drilling, A., Morales, S., Jardeleza, C., Vreugde, S., Speck, P., & Wormald, P. (2014). Bacteriophage reduces biofilm of Staphylococcus aureus ex vivo isolates from chronic rhinosinusitis patients. American Journal of Rhinology and Allergy, 28(1), 3-11.
Scopus28 WoS27 Europe PMC192014 Jardeleza, C., Rao, S., Thierry, B., Gajjar, P., Vreugde, S., Prestidge, C., & Wormald, P. (2014). Liposome-encapsulated ISMN: a novel nitric oxide-based therapeutic agent against Staphylococcus aureus biofilms. PLoS One, 9(3), 1-9.
Scopus23 WoS20 Europe PMC82014 Drilling, A., Morales, S., Boase, S., Jervis-Bardy, J., James, C., Jardeleza, C., . . . Wormald, P. (2014). Safety and efficacy of topical bacteriophage and ethylenediaminetetraacetic acid treatment of Staphylococcus aureus infection in a sheep model of sinusitis. International Forum of Allergy & Rhinology, 4(3), 176-186.
Scopus24 WoS25 Europe PMC182014 Paramasivan, S., Drilling, A., Jardeleza, C., Jervis-Bardy, J., Vreugde, S., & Wormald, P. (2014). Methylglyoxal-augmented manuka honey as a topical anti-Staphylococcus aureus biofilm agent: safety and efficacy in an in vivo model. International Forum of Allergy & Rhinology, 4(3), 187-195.
Scopus25 WoS26 Europe PMC192014 Goggin, R., Jardeleza, C., Wormald, P., & Vreugde, S. (2014). Colloidal silver: a novel treatment for Staphylococcus aureus biofilms?. International Forum of Allergy & Rhinology, 4(3), 171-175.
Scopus15 WoS16 Europe PMC102014 Goggin, R., Jardeleza, C., Wormald, P., & Vreugde, S. (2014). Corticosteroids directly reduce Staphylococcus aureus biofilm growth: an in vitro study. The Laryngoscope, 124(3), 602-607.
Scopus12 WoS13 Europe PMC122013 Jardeleza, C., Miljkovic, D., Baker, L., Boase, S., Tan, N., Koblar, S., . . . Vreugde, S. (2013). Inflammasome gene expression alterations in Staphylococcus aureus biofilm-associated chronic rhinosinusitis. Rhinology, 51(4), 315-322.
Scopus7 WoS7 Europe PMC52013 Cantero Cajas, D., Cooksley, C., Bassiouni, A., Wormald, P., & Vreugde, S. (2013). Staphylococcus aureus biofilm activates the nucleotide-binding oligomerization domain containing 2 (Nod2) pathway and proinflammatory factors on a human sinonasal explant model. International Forum of Allergy & Rhinology, 3(11), 877-884.
Scopus9 WoS9 Europe PMC82013 Cantero Cajas, D., Cooksley, C., Jardeleza, C., Bassiouni, A., Jones, D., Wormald, P., & Vreugde, S. (2013). A human nasal explant model to study Staphylococcus aureus biofilm in vitro. International Forum of Allergy & Rhinology, 3(7), 556-562.
Scopus12 WoS11 Europe PMC72013 Tan, N., Foreman, A., Jardeleza, C., Douglas, R., Vreugde, S., & Wormald, P. (2013). Intracellular Staphylococcus aureus: the Trojan horse of recalcitrant chronic rhinosinusitis?. International Forum of Allergy & Rhinology, 3(4), 261-266.
Scopus36 WoS34 Europe PMC272013 Jardeleza, C., Jones, D., Baker, L., Miljkovic, D., Boase, S., Tan, N., . . . Wormald, P. (2013). Gene expression differences in nitric oxide and reactive oxygen species regulation point to an altered innate immune response in chronic rhinosinusitis. International Forum of Allergy & Rhinology, 3(3), 193-198.
Scopus7 WoS7 Europe PMC32012 Tan, N., Tran, H., Foreman, A., Jardeleza, C., Vreugde, S., & Wormald, P. (2012). Identifying intracellular Staphylococcus aureus in chronic rhinosinusitis: A direct comparison of techniques. American Journal of Rhinology & Allergy, 26(6), 444-449.
Scopus15 WoS15 Europe PMC122012 Tan, N., Tran, H., Roscioli, E., Wormald, P., & Vreugde, S. (2012). Prevention of false positive binding during immunofluorescence of Staphylococcus aureus infected tissue biopsies. Journal of Immunological Methods, 384(1-2), 111-117.
Scopus7 WoS5 Europe PMC42006 Vreugde, S., Ferrai, C., Miluzio, A., Hauben, E., Marchisio, P., Crippa, M., . . . Biffo, S. (2006). Nuclear myosin VI enhances RNA polymerase II-dependent transcription. Molecular Cell, 23(5), 749-755.
Scopus90 WoS81 Europe PMC702006 Friedmann, E., Hauben, E., Maylandt, K., Schleeger, S., Vreugde, S., Lichtenthaler, S., . . . Martoglio, B. (2006). SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. Nature Cell Biology, 8(8), 849-854.
2006 Friedmann, E., Hauben, E., Maylandt, K., Schleeger, S., Vreugde, S., Lichtenthaler, S., . . . Martoglio, B. (2006). SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production. Nature Cell Biology, 8(8), 843-848.
Scopus137 WoS135 Europe PMC1082002 Vreugde, S., Erven, A., Kros, C., Marcotti, W., Fuchs, H., Kurima, K., . . . Steel, K. (2002). Beethoven, a mouse model for dominant, progressive hearing loss DFNA36. Nature Genetics, 30(3), 257-258.
Scopus161 WoS155 Europe PMC1242002 Walsh, T., Walsh, V., Vreugde, S., Hertzano, R., Shahin, H., Haika, S., . . . Avraham, K. (2002). From flies' eyes to our ears: Mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30. Proceedings of the National Academy of Sciences of the United States of America, 99(11), 7518-7523.
Scopus154 WoS141 Europe PMC1152002 Adato, A., Vreugde, S., Joensuu, T., Avidan, N., Hamalainen, R., Belenkiy, O., . . . Lancet, D. (2002). USH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses. European Journal of Human Genetics, 10(6), 339-350.
Scopus111 WoS102 Europe PMC822000 Frydman, M., Vreugde, S., Nageris, B., Weiss, S., Vahava, O., & Avraham, K. (2000). Clinical characterization of genetic hearing loss caused by a mutation in the POU4F3 transcription factor. Archives of Otolaryngology - Head and Neck Surgery, 126(5), 633-637.
Scopus22 WoS17 Europe PMC112000 Sobe, T., Vreugde, S., Shahin, H., Berlin, M., Davis, N., Kanaan, M., . . . Avraham, K. (2000). The prevalence and expression of inherited connexin 26 mutations associated with nonsyndromic hearing loss in the Israeli population. Human Genetics, 106(1), 50-57.
Scopus135 WoS118 Europe PMC941999 Sobe, T., Erlich, P., Berry, A., Korostichevsky, M., Vreugde, S., Avraham, K., . . . Shohat, M. (1999). High frequency of the deafness-associated 167delT mutation in the connexin 26 (GJB2) gene in Israeli Ashkenazim [2]. American Journal of Medical Genetics, 86(5), 499-500.
Scopus57 Europe PMC341999 Vreugde, S., Duttmann, R., Halama, A., & Deron, P. (1999). Metastasis of a renal cell carcinoma to the nose and paranasal sinuses. Acta Oto-Rhino-Laryngologica Belgica, 53(2), 129-131.
Scopus8 Europe PMC61999 Sobe, T., Erlich, P., Berry, A., Korostichevsky, M., Vreugde, S., Avraham, K., . . . Shohat, M. (1999). High frequency of the deafness-associated 167delT mutation in the connexin 26 (GJB2) gene in Israeli Ashkenazim. AMERICAN JOURNAL OF MEDICAL GENETICS, 86(5), 499-500.
WoS521999 Sobe, T., Erlich, P., Berry, A., Korostichevsky, M., Vreugde, S., Avraham, K. B., . . . Shohat, M. (1999). High frequency of the deafness‐associated 167delT mutation in the connexin 26 (GJB2) gene in Israeli Ashkenazim. American Journal of Medical Genetics, 86(5), 499-500.
1997 De Maeseneer, M., Vreugde, S., Laureys, S., Sartoris, D., De Ridder, F., & Osteaux, M. (1997). Calcific tendinitis of the longus colli muscle. Head and Neck, 19(6), 545-548.
Scopus41 WoS32 Europe PMC231994 Vreugde, S. (1994). Nutritional aspects of dysphagia.. Acta oto-rhino-laryngologica Belgica, 48(2), 229-234.
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Conference Items
Year Citation 2016 Lau, A. H. Y., Lester, S., Moraitis, S., Ou, J., Rischmueller, M., Wormald, P. J., & Vreugde, S. (2016). Tertiary Lymphoid Organ in Chronic Rhinosinusitis. Poster session presented at the meeting of 2016 ASMR South Australian Scientific Meeting. Convention Centre, Adelaide, South Australia, Australia.
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 Principal Supervisor Synthetic Phage and Phage Lysins as Antibacterial Agents Against Multi-Drug Resistant Pathogens Doctor of Philosophy Doctorate Full Time Mr Roshan Nepal 2019 Principal Supervisor Tertiary Lymphoid Organs in Recalcitrant Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Mr Ghais Houtak 2018 Principal Supervisor The host-microbe interface in chronic rhinosinusitis Doctor of Philosophy Doctorate Full Time Mr Sathish Paramasivan 2018 Co-Supervisor New Treatments for Chronic Rhinosinusitis: Exploring the Role of Viruses Master of Philosophy (Surgery) Master Full Time Dr Anna Katharina Megow 2018 Co-Supervisor Chitosan-Dextran Gel with and without Deferiporone and Gallium Protoporphyrin: wound healing and post operative outcomes in Surgery Doctor of Philosophy Doctorate Full Time Rajan Vediappan 2018 Principal Supervisor The Role of Viruses in Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Dr Rachel Katherine Goggin 2018 Principal Supervisor Novel treatments of airway infections Doctor of Philosophy Doctorate Full Time Miss Sholeh Feizi 2018 Principal Supervisor Investigation Potential Microbiome Therapy for Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Mrs Martha Menberu 2017 Co-Supervisor Effect of Staphylococcus aureus toxins on the nasal epithelial barrier in Chronic Rhino-sinusitis Doctor of Philosophy Doctorate Full Time Dr Beula Subashini Panchatcharam 2017 Co-Supervisor Development of an animal model of endoscopic small vessel haemorrhage control, Brain Manipulation and Dural closure Master of Philosophy (Surgery) Master Full Time Dr Annika Reann Mascarenhas 2017 Co-Supervisor Bacteriophage Therapy for Chronic Rhinosinusitis: Targeting Pseudomonas Aeruginosa Biofilms Doctor of Philosophy Doctorate Full Time Miss Stephanie Anne Fong -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2016 - 2019 Co-Supervisor Corticosteroids and the Sinonasal Microbiome Doctor of Philosophy Doctorate Full Time Dr Lisa Mary Cherian 2016 - 2017 Co-Supervisor The microbiome of otitis media with effusion and the influence of Alloicoccus otitidis on Haemophilus influenzae in polymicrobial biofilm Doctor of Philosophy Doctorate Full Time Dr Chun Chan 2015 - 2018 Principal Supervisor An Immunological Perspective of the Mucosal Inflammation in Chronic Rhinosinusitis – Lymphoid Neo-organogenesis and Humoral Immunity Doctor of Philosophy Doctorate Full Time Mr Aden Lau 2015 - 2018 Co-Supervisor The Mucosal Barrier in Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Mr Jae Viktor Murphy 2014 - 2017 Co-Supervisor The Role of Immune Cells in Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Ms Dijana Miljkovic 2014 - 2017 Principal Supervisor Towards Novel Antibiofilm Strategies Doctor of Philosophy Doctorate Full Time Dr Katharina Richter 2013 - 2015 Co-Supervisor Management of Major Vessel Haemorrhage in Endonasal Surgery Doctor of Philosophy Doctorate Full Time Vikram Padhye 2012 - 2014 Co-Supervisor Nitric Oxide and Staphylococcus aureus Biofilms: Defining their Intricate Relationship in Chronic Rhinosinusitis Doctor of Philosophy Doctorate Part Time Dr Camille Jardeleza 2012 - 2014 Co-Supervisor The innate immune response to Staphylococcus aureus biofilms on human sinonasal explants Doctor of Philosophy Doctorate Full Time Mr Daniel Anibal Cantero Cajas 2012 - 2013 Co-Supervisor Intracellular Staphylococcus aureus in chronic rhinosinusitis Doctor of Philosophy Doctorate Full Time Dr Neil Cheng-Wen Tan 2012 - 2015 Co-Supervisor The Role of Surgery and Disease Load in Refractory Chronic Rhinosinusitis Doctor of Philosophy Doctorate Full Time Mr Ahmed Bassiouni 2012 - 2015 Co-Supervisor The Effect of Chitosan Dextran Gel as a Haemostatic and Anti Adhesion Agent in the Central Nervous System and Evaluation of Haemostatic Mechanism of Skeletal Muscle Tissue Doctor of Philosophy Doctorate Full Time Dr Sukanya Rajiv 2012 - 2014 Co-Supervisor The Chronic Rhinosinusitis Microbiome Doctor of Philosophy Doctorate Full Time Dr Edward John Cleland
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Committee Memberships
Date Role Committee Institution Country 2019 - ongoing Chair BHI Strategic Research Directions Committee Basil Hetzel Institute Australia 2016 - ongoing Member TQEH Human Research Ethics Committee — — 2014 - ongoing Member The Basil Hetzel Institute Management Committee The Bsil Hetzel Institute Australia 2011 - ongoing Chair Selection committee for scientist positions — — -
Memberships
Date Role Membership Country 2017 - ongoing Member American Society of Microbiology — -
Editorial Boards
Date Role Editorial Board Name Institution Country 2018 - ongoing Associate Editor Frontiers in Cellular and Infection Microbiology Frontiers Journals United Kingdom 2016 - ongoing Associate Editor Sinusitis — —
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