Sarah Boyle

Dr Sarah Boyle

Research Fellow

Centre for Cancer Biology

College of Health

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Dr. Sarah Boyle leads the Cancer Matrix and Mechanics Group within the Tumour Microenvironment Laboratory at the Centre for Cancer Biology.
A current ARC DECRA Research Fellow, Sarah's interdisciplinary research program focusses on understanding how mechanical stresses and inputs, the extracellular matrix, and mechanotransduction signalling contribute to cancer growth, metastasis, and the generation of a pro-tumourigenic microenvironment in breast and other solid cancers.

Year Citation
2024 Pittar, A., Buckley, E. J., Boyle, S. T., Ibbetson, S. J., & Samuel, M. S. (2024). Enhanced RHO-ROCK signaling is associated with CRELD2 production and fibroblast recruitment in cutaneous squamous cell carcinoma. Cytoskeleton, 81(12), 864-871.
DOI Scopus3 WoS3 Europe PMC4
2023 Boyle, S. T. (2023). RISING STARS: Hormonal regulation of the breast cancer microenvironment. Journal of molecular endocrinology, 70(3, article no. e220174), 1-16.
DOI Scopus7 Europe PMC7
2023 Orang, A., Dredge, B. K., Liu, C. Y., Bracken, J. M., Chen, C. -H., Sourdin, L., . . . Bracken, C. P. (2023). Basonuclin-2 regulates extracellular matrix production and degradation. Life Science Alliance, 6(10), e202301984-1-e202301984-17.
DOI Scopus3 WoS3 Europe PMC7
2022 Law, A. M. K., Chen, J., Colino-Sanguino, Y., Fuente, L. R. D. L., Fang, G., Grimes, S. M., . . . Gallego-Ortega, D. (2022). ALTEN: A High-Fidelity Primary Tissue-Engineering Platform to Assess Cellular Responses Ex Vivo. Advanced Science, 9(21), 2103332-1-2103332-19.
DOI Scopus5 WoS5 Europe PMC9
2022 Le Cerf, B. A., Pyne, N., Kular, J., Boyle, S. T., Beattie, D. A., Krasowska, M., & Samuel, M. S. (2022). Nano-mechanical analyses of native and cross-linked collagen I matrices reveal the mechanical complexity of homogenous samples. Frontiers in Physics, 10(835038), 1-11.
DOI Scopus2 WoS2
2020 Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., . . . Samuel, M. S. (2020). ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism. Nature Cell Biology, 22(7), 882-895.
DOI Scopus60 WoS60 Europe PMC56
2020 Whyte, C. E., Osman, M., Kara, E. E., Abbott, C., Foeng, J., McKenzie, D. R., . . . McColl, S. R. (2020). ACKR4 restrains antitumor immunity by regulating CCL21. Journal of Experimental Medicine, 217(6), 1-S4.
DOI Scopus29 WoS29 Europe PMC29
2020 Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., . . . Samuel, M. S. (2020). Publisher Correction: ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.. Nat Cell Biol, 22(7), 908.
DOI Scopus5 WoS4 Europe PMC6
2020 Boyle, S. T., Mittal, P., Kaur, G., Hoffmann, P., Samuel, M. S., & Klingler-Hoffmann, M. (2020). Uncovering tumor−stroma inter-relationships using MALDI Mass spectrometry imaging. Journal of Proteome Research, 19(10), 4093-4103.
DOI Scopus16 WoS15 Europe PMC13
2020 Boyle, S. T., Johan, M. Z., & Samuel, M. S. (2020). Tumour-directed microenvironment remodelling at a glance. Journal of Cell Science, 133(24), jcs247783-1-jcs247783-9.
DOI Scopus14 WoS13 Europe PMC8
2018 Boyle, S. T., Kular, J., Nobis, M., Ruszkiewicz, A., Timpson, P., & Samuel, M. S. (2018). Acute compressive stress activates RHO/ROCK-mediated cellular processes. Small GTPases, 11(5), 1-17.
DOI Scopus46 Europe PMC43
2017 Boyle, S., Gieniec, K., Gregor, C., Faulkner, J., McColl, S., & Kochetkova, M. (2017). Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells. Molecular Cancer, 16(1), 19-1-19-8.
DOI Scopus26 WoS27 Europe PMC22
2016 Boyle, S., Ingman, W., Poltavets, V., Faulkner, J., Whitfield, R., McColl, S., & Kochetkova, M. (2016). The chemokine receptor CCR7 promotes mammary tumorigenesis through amplification of stem-like cells. Oncogene, 35(1), 105-115.
DOI Scopus33 WoS33 Europe PMC30
2016 Boyle, S. T., & Samuel, M. S. (2016). Mechano-reciprocity is maintained between physiological boundaries by tuning signal flux through the Rho-associated protein kinase. Small GTPases, 7(3), 139-146.
DOI Scopus26 Europe PMC22
2016 Samuel, M., Rath, N., Masre, S., Boyle, S., Greenhalgh, D., Kochetkova, M., . . . Olson, M. (2016). Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein. Genesis, 54(12), 636-646.
DOI Scopus10 WoS9 Europe PMC9
2015 Boyle, S., Faulkner, J., McColl, S., & Kochetkova, M. (2015). The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages. Molecular Cancer, 14(1), 115-1-115-14.
DOI Scopus51 WoS50 Europe PMC54
2014 Boyle, S. T., & Kochetkova, M. (2014). Breast cancer stem cells and the immune system: promotion, evasion and therapy. Journal of Mammary Gland Biology and Neoplasia, 19(2), 203-211.
DOI Scopus29 WoS29 Europe PMC21

  • Defining the casual relationships between the tumour ECM and cancer outcomes, NHMRC - Ideas Grants, 01/01/2025 - 31/12/2028

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Co-Supervisor Understanding how the Epigenetic Field Effect Exerted by Cancers upon their Microenvironment Promotes Tumour Progression Doctor of Philosophy Doctorate Full Time Moganalaxmi Reckdharajkumar
2025 Co-Supervisor Understanding how the Epigenetic Field Effect Exerted by Cancers upon their Microenvironment Promotes Tumour Progression Doctor of Philosophy Doctorate Full Time Moganalaxmi Reckdharajkumar

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