Sandra Orgeig

Prof Sandra Orgeig

Dean of Graduate Studies

School of Pharmacy and Biomedical Science

College of Health

I am the Dean of Graduate Studies, with responsibility for overseeing the University's research degree programs and supporting the training of our research degree candidates. I am also Professor in Pulmonary Biology in UniSA: Clinical & Health Sciences.
After completing my initial schooling in Biochemistry at the University of Cape Town, South Africa, I moved to Adelaide in 1990 and completed my PhD (1994) in Evolutionary Respiratory Physiology at Flinders University. Following a move to the University of Adelaide, I held consecutive ARC Postdoctoral and mid-career Research Fellowships first in Physiology and then in Environmental Biology. Thereafter in 2007 I took on an academic position at the University of South Australia, where I headed the Molecular & Evolutionary Physiology of the Lung Laboratory and was also the inaugural Program Director for the Bachelor of Medical Science, which I developed together with a joint degree with the Australian National University.
Throughout my research career I have taken a broad multidisciplinary approach including evolutionary, physiological, developmental and biomedical disciplinary tools to understand the evolution, development, function and regulation of pulmonary surfactant in health and disease across a range of animal models. My current research interests include understanding the role of surfactant and lung dysfunction in a group of devastating metabolic genetic diseases known as lysosomal storage disorders, as well as understanding the disease mechanisms in the initiation and development of lung cancer.
Awards and Fellowships:

National Citation for Outstanding Contributions to Student Learning (UniSA LT Elearning Team), Australian Awards for University Teaching, 2019 (for creating innovative resources for delivering a digitally-enriched curriculum in the Health Sciences)
Citation for Outstanding Contributions to Digital Learning, UniSA 2018 (for creating innovative resources for delivering a digitally-enriched curriculum in the Health Sciences)
Citation for Outstanding Contributions to Student Learning, UniSA 2016 (for promoting the teaching-research nexus)
Young Tall Poppy Award for South Australia 2002
Fenner Medal, Australian Academy Science 2002
ARC Research Fellowship 1999
ARC Postdoctoral Research Fellowship 1996

Pulmonary Surfactant

Surfactant is a complex mixture of lipids and proteins produced by alveolar epithelial cells and secreted into the fluid lining of the lung, where it forms a film at the air-liquid interface. The surfactant film dynamically regulates interfacial surface tension with lung volume to prevent alveolar collapse and reduce the work of breathing. As this critical system develops late during gestation, prematurely-born babies are at risk of developing respiratory distress, a condition often successfully treated with a combination of positive pressure ventilation and/or artificial surfactants. Within the area of pulmonary surfactant, we are interested in environmental and genetic effects on the development of the system as well as on the effect of temperature on the biophysical function of the system.

Environmental effects on lung and surfactant development

We are interested in the development of the surfactant system prior to birth/hatching in a variety of animal models, demonstrating different birthing strategies. We are particularly interested in the differences in the timing of development between species that experience different selection pressures (e.g. hypoxia or variable temperatures). We also examine the interplay between genetics and the environment in shaping the development of the fetus and the outcome for the newborn/hatchling. We are also collaborating with the Early Origins of Adult Health Research Group to determine the effects of intrauterine growth restriction (IUGR) on surfactant maturation. Infants that are subjected to IUGR are small at birth and are at an increased risk of developing respiratory distress. We wish to establish the mechanisms and timing of surfactant maturation during late gestation in relation to environmental factors that lead to IUGR, using placentally restricted sheep and undernourished or hypoxia-exposed guinea pigs. We are also examining the effect of under- and overnourishment on the regulation of development of the surfactant system.

Lung and surfactant alterations in mucopolysaccharidosis type IIIA mice

This project represents a collaboration with the Mechanisms in Cell Biology and Diseases Research Group. We are investigating the mechanisms leading to respiratory disease in mucopolysaccharidosis type IIIA (MPS IIIA). We have recently described the presence of storage material in the lung of MPS IIIA mice and suggest that this may impair the cellular processing of pulmonary surfactant, which may affect the mechanical function of the lung as well as impair innate pulmonary immunity. In addition, we have for the first time observed lipid droplets and abnormal lamellar bodies, as well as altered lung structure with increased collagen deposition in lung parenchyma. We are continuing to investigate surfactant dysfunction in MPSIIIA mice from a biochemical, molecular, subcellular, structural and biophysical perspective.

Year Citation
2025 Kunchala, S. R., van Dijk, A., Veldhuizen, E. J. A., Haagsman, H. P., & Orgeig, S. (2025). Adaptation and conservation of CL-10/11 in avian lungs: implications for their role in pulmonary innate immune protection. Philosophical Transactions of the Royal Society B: Biological Sciences, 380(1920), 1-12.
DOI
2025 Mcgillick, E. V., Orgeig, S., Allison, B. J., Brain, K. L., Niu, Y., Itani, N., . . . Morrison, J. L. (2025). Antenatal Vitamin C differentially affects lung development in normally grown and growth restricted sheep. Pediatric Research, online(1), 1-12.
DOI
2025 Ngai, Y. T., Young, C., Parkinson-Lawrence, E. J., Wimmer-Kleikamp, S., Mittal, P., Beard, H., . . . Hoffmann, P. (2025). Defining lung pathogenesis in a murine model of mucopolysaccharidosis Type I by proteomic analysis. Molecular Genetics and Metabolism, 146(1-2), 109231.
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2024 Paget, T. L., Larcombe, A. N., Pinniger, G. J., Tsioutsias, I., Schneider, J. P., Parkinson-Lawrence, E. J., & Orgeig, S. (2024). Mucopolysaccharidosis (MPS IIIA) mice have increased lung compliance and airway resistance, decreased diaphragm strength, and no change in alveolar structure. American Journal of Physiology Lung Cellular and Molecular Physiology, 326(6), L713-L726.
DOI Scopus2 WoS2 Europe PMC1
2024 Edwards, H., Buisman-Pijlman, F. T., Esterman, A., Phillips, C., Orgeig, S., & Gordon, A. (2024). Exogenous oxytocin administered to induce or augment labour is positively associated with quality of observed mother-infant bonding. Comprehensive Psychoneuroendocrinology, 20, 100262-1-100262-9.
DOI WoS1
2024 Ngai, Y. T., Briggs, M. T., Mittal, P., Young, C., Parkinson-Lawrence, E., Klingler-Hoffmann, M., . . . Hoffmann, P. (2024). Mass spectrometry imaging protocol for spatial mapping of lipids, N-glycans and peptides in murine lung tissue. Rapid Communications in Mass Spectrometry, 38(9), e9721.
DOI Scopus6 WoS4 Europe PMC3
2024 McGillick, E. V., Orgeig, S., Allison, B. J., Brain, K. L., Bertossa, M. R., Holman, S. L., . . . Giussani, D. A. (2024). Chronic fetal hypoxia and antenatal Vitamin C exposure differentially regulate molecular signalling in the lung of female lambs in early adulthood. Frontiers in Physiology, 15, 14 pages.
DOI Scopus2 WoS1 Europe PMC1
2023 Lock, M. C., Botting, K. J., Allison, B. J., Niu, Y., Ford, S. G., Murphy, M. P., . . . Morrison, J. L. (2023). MitoQ as an antenatal antioxidant treatment improves markers of lung maturation in healthy and hypoxic pregnancy. Journal of Physiology, 601(16), 3647-3665.
DOI Scopus13 WoS14 Europe PMC11
2023 Kunchala, S. R., van Dijk, A., Veldhuizen, E. J. A., Donnellan, S. C., Haagsman, H. P., & Orgeig, S. (2023). Avian surfactant protein (SP)-A2 first arose in an early tetrapod before the divergence of amphibians and gradually lost the collagen domain. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 139(104582), 14 pages.
DOI Scopus3 WoS3 Europe PMC3
2022 Edwards, H., Buisman-Pijlman, F. T., Esterman, A., Phillips, C., Smart, L., Orgeig, S., & Gordon, A. (2022). Assessing mother-infant bonding: reliability of the recorded interaction task.. Journal of reproductive and infant psychology, 42(3), 1-11.
DOI Scopus1 WoS1 Europe PMC1
2022 McGillick, E. V., Orgeig, S., Allison, B. J., Brain, K. L., Niu, Y., Itani, N., . . . Giussani, D. A. (2022). Molecular regulation of lung maturation in near-term fetal sheep by maternal daily vitamin C treatment in late gestation. Pediatric Research, 91(4), 828-838.
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2021 Lock, M. C., Botting, K. J., Niu, Y., Ford, S. G., Orgeig, S., Giussani, D. A., & Morrison, J. L. (2021). Dexamethasone reduces 11b-hydroxysteroid dehydrogenase 1 expression the fetal lung following hypoxic pregnancy. Reproductive Sciences, 28(S1), 260.
2021 Ren, J., Darby, J. R. T., Lock, M. C., Holman, S. L., Saini, B. S., Bradshaw, E. L., . . . Morrison, J. L. (2021). Impact of maternal late gestation undernutrition on surfactant maturation, pulmonary blood flow and oxygen delivery measured by magnetic resonance imaging in the sheep fetus. Journal of Physiology, 599(20), 4705-4724.
DOI Scopus11 WoS8 Europe PMC8
2021 Ren, J., Lock, M. C., Darby, J. R. T., Orgeig, S., Holman, S. L., Quinn, M., . . . Morrison, J. L. (2021). PPARγ activation in late gestation does not promote surfactant maturation in the fetal sheep lung. Journal of Developmental Origins of Health and Disease, 12(6), 963-974.
DOI Scopus4 WoS12 Europe PMC3
2021 Edwards, H., Buisman-Pijlman, F. T. A., Esterman, A., Phillips, C., Orgeig, S., & Gordon, A. (2021). The Recorded Interaction Task: A Validation Study of a New Observational Tool to Assess Mother-Infant Bonding. Journal of Midwifery and Women's Health, 66(2), 249-255.
DOI Scopus4 WoS4 Europe PMC3
2021 Paget, T. L., Parkinson-Lawrence, E. J., Trim, P. J., Autilio, C., Panchal, M. H., Koster, G., . . . Orgeig, S. (2021). Increased Alveolar Heparan Sulphate and Reduced Pulmonary Surfactant Amount and Function in the Mucopolysaccharidosis IIIA Mouse.. Cells, 10(4), 849.
DOI Scopus8 WoS7 Europe PMC5
2021 Paget, T. L., Parkinson Lawrence, E. J., & Orgeig, S. (2021). The role of surfactant and distal lung dysfunction in the pathology of lysosomal storage diseases. Current Opinion in Physiology, 23(article no. 100467), 1-8.
DOI Scopus2 WoS1
2020 Darby, J. R. T., Varcoe, T. J., Orgeig, S., & Morrison, J. L. (2020). Cardiorespiratory consequences of intrauterine growth restriction: influence of timing, severity and duration of hypoxaemia. Theriogenology, 150, 84-95.
DOI Scopus54 WoS49 Europe PMC40
2019 Paget, T. L., Parkinson Lawrence, E. J., & Orgeig, S. (2019). Interstitial lung disease and surfactant dysfunction as a secondary manifestation of disease: insights from lysosomal storage disorders. Drug discovery today: disease models, 29, 35-42.
DOI Scopus8
2018 Orgeig, S., Autilio, C., Echaide, M., Paget, T., Perez Gil, J., & Parkinson Lawrence, E. (2018). Pulmonary surfactant activity is reduced in mucopolysaccharidosis type IIIa mice. Respirology, 23(S1), 116.
2018 Orgeig, S., Paget, T., Panchal, M., Postle, A., & Parkinson Lawrence, E. (2018). Alveolar surfactant phospholipid content is reduced in mucopolysaccharidosis type IIA lungs. Respirology, 23(S1), 183.
2017 Lock, M., McGillick, E., Orgeig, S., McMillen, I., Mühlhäusler, B., Zhang, S., & Morrison, J. (2017). Differential effects of late gestation maternal overnutrition on the regulation of surfactant maturation in fetal and postnatal life. The Journal of physiology, 595(21), 6635-6652.
DOI Scopus24 WoS23 Europe PMC22
2017 Soo, J., Orgeig, S., McGillick, E., Zhang, S., McMillen, I., & Morrison, J. (2017). Normalisation of surfactant protein -A and -B expression in the lungs of low birth weight lambs by 21 days old. PLoS ONE, 12(9), e0181185.
DOI Scopus10 WoS9 Europe PMC9
2017 Orgeig, S., McGillick, E. V., Allison, B. J., Brain, K. L., Niu, Y. G., Itani, N., . . . Morrison, J. L. (2017). Antenatal vitamin C administration in sheep is protective against fetal hypoxemia-induced oxidative stress and airway remodelling in early adulthood. Respirology, 22(S2), 68.
2017 McGillick, E. V., Lock, M. C., Orgeig, S., & Morrison, J. (2017). Maternal obesity mediated predisposition to respiratory complications at birth and in later life: understanding the implications of the obesogenic intrauterine environment. Paediatric respiratory reviews, 21, 11-18.
DOI Scopus51 WoS45 Europe PMC38
2017 McGillick, E. V., Orgeig, S., Allison, B. J., Brain, K. L., Niu, Y., Itani, N., . . . Morrison, J. L. (2017). Maternal chronic hypoxia increases expression of genes regulating lung liquid movement and surfactant maturation in male fetuses in late gestation. Journal of Physiology, 595(13), 4329-4350.
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2017 McGillick, E. V., Orgeig, S., Giussani, D. A., & Morrison, J. L. (2017). Chronic hypoxaemia as a molecular regulator of fetal lung development: implications for risk of respiratory complications at birth. Paediatric respiratory reviews, 21, 3-10.
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2017 Mukherjee, S., Prestidge, C. A., Orgeig, S., Panda, A. K., & Moulik, S. P. (2017). Physicochemical Investigation on the Pulmonary Surfactant of Some Vertebrates. Journal of surface science and technology, 33(3-4), 127-136.
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2016 McGillick, E. V., Orgeig, S., Williams, M. T., & Morrison, J. L. (2016). Risk of respiratory distress syndrome and efficacy of glucocorticoids: are they the same in the normally grown and growth-restricted infant?. Reproductive sciences, 23(11), 1459-1472.
DOI Scopus24 WoS20 Europe PMC17
2016 Orgeig, S., Morrison, J. L., & Daniels, C. B. (2016). Evolution, development, and function of the pulmonary surfactant system in normal and perturbed environments. Comprehensive Physiology, 6(1), 363-422.
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2016 McGillick, E. V., Orgeig, S., & Morrison, J. L. (2016). Structural and molecular regulation of lung maturation by intratracheal vascular endothelial growth factor administration in the normally grown and placentally restricted fetus. Journal of physiology, 594(5), 1399-1420.
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2016 McGillick, E. V., Orgeig, S., & Morrison, J. L. (2016). Regulation of lung maturation by prolyl hydroxylase domain inhibition in the lung of the normally grown and placentally restricted fetus in late gestation. American journal of physiology, 310(11), 1226-1243.
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2015 McGillick, E. V., Orgeig, S., Allison, B. J., Brain, K. L., Niu, Y., Itani, N., . . . Giussani, D. A. (2015). Maternal antioxidant treatment increases expression of genes regulating hypoxia signalling, sodium movement and surfactant maturation in the fetal lung. Reproductive sciences, 22(no. 0-073), 80A.
2015 Lock, M., McGillick, E., Orgeig, S., Zhang, S., McMillen, I., & Morrison, J. (2015). Mature Surfactant Protein-B Expression by Immunohistochemistry as a Marker for Surfactant System Development in the Fetal Sheep Lung. Journal of Histochemistry and Cytochemistry, 63(11), 866-878.
DOI Scopus25 WoS23 Europe PMC19
2015 Orgeig, S., McGillick, E., Botting, K., Zhang, S., McMillen, I., & Morrison, J. (2015). Increased lung prolyl hydroxylase and decreased glucocorticoid receptor are related to decreased surfactant protein in the growth-restricted sheep fetus. American Journal of Physiology-Lung Cellular and Molecular Physiology, 309(1), L84-L97.
DOI Scopus42 WoS35 Europe PMC34
2014 McGillick, E. V., Morrison, J. L., McMillen, I. C., & Orgeig, S. (2014). Intrafetal glucose infusion alters glucocorticoid signalling and reduces surfactant protein mRNA expression in the lung of the late gestation sheep fetus. American Journal of Physiology : Regulatory, Integrative and Comparative Physiology, 307(5), R538-R545.
DOI Scopus48 Europe PMC38
2013 Lock, M., McGillick, E. V., Orgeig, S., McMillen, I. C., & Morrison, J. L. (2013). Regulation of fetal lung development in response to maternal overnutrition. Clinical and experimental pharmacology and physiology, 40(11), 803-816.
DOI Scopus43 WoS39 Europe PMC32
2013 McGillick, E. V., Orgeig, S., McMillen, I. C., & Morrison, J. L. (2013). The fetal sheep lung does not respond to cortisol infusion during the late canalicular phase of development. Physiological reports, 1(6, article no. e00130), 1-15.
DOI Scopus50
2013 Suri, L. N. M., Cruz, A., Veldhuizen, R. A. W., Staples, J. F., Possmayer, F., Orgeig, S., & Perez Gil, J. (2013). Adaptations to hibernation in lung surfactant composition of 13-lined ground squirrels influence surfactant lipid phase segregation properties. Biochimica et biophysica acta: biomembranes, 1828(8), 1707-1714.
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2012 Atik, A., Sozo, F., Orgeig, S., Suri, L. N. M., Hanita, T., Harding, R., & De, M. R. (2012). Long-term pulmonary effects of intrauterine exposure to endotoxin following preterm birth in sheep. Reproductive sciences, 19(12), 1352-1364.
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2012 Suri, L. N. M., McCaig, L., Picardi, M. V., Ospina, O. L., Veldhuizen, R. A. W., Staples, J. F., . . . Orgeig, S. (2012). Adaptation to low body temperature influences pulmonary surfactant composition thereby increasing fluidity while maintaining appropriately ordered membrane structure and surface activity. Biochimica et biophysica acta: biomembranes, 1818(7), 1581-1589.
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2012 Blacker, H. A., & Orgeig, S. (2012). Differential mRNA and tissue expression of lymphangiogenic growth factors (VEGF-C and -D) and their receptor (VEGFR-3) during tail regeneration in a gecko. Journal of Comparative Physiology B, 182(1), 109-126.
DOI Scopus2 WoS2 Europe PMC2
2012 Morrison, J. L., Botting, K. J., Soo, P. S., McGillick, E. V., Hiscock, J., Zhang, S., . . . Orgeig, S. (2012). Antenatal steroids and the IUGR fetus: are exposure and physiological effects on the lung and cardiovascular system the same as in normally grown fetuses?. Journal of pregnancy, 2012(839656), 1-15.
DOI Scopus78 WoS61 Europe PMC45
2011 Orgeig, S., Morrison, J. L., & Daniels, C. B. (2011). Prenatal development of the pulmonary surfactant system and the influence of hypoxia. Respiratory physiology and neurobiology, 178(1), 129-145.
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2010 Possmayer, F., Hall, S., Haller, T., Petersen, N. O., Zuo, Y. Y., de la Serna, J. B., . . . Orgeig, S. (2010). Recent advances in alveolar biology : some new looks at the alveolar interface. Respiratory physiology and neurobiology, 173(S1), S55-S64.
DOI Scopus48 Europe PMC41
2010 Orgeig, S., Crittenden, T. A., Marchant, C., McMillen, I. C., & Morrison, J. L. (2010). Intrauterine growth restriction delays surfactant protein maturation in the sheep fetus. American journal of physiology : lung cellular and molecular physiology, 298(4), L575-L583.
DOI Scopus99 Europe PMC74
2010 Maina, J. N., West, J. B., Orgeig, S., Foot, N. J., Daniels, C. B., Kiama, S. G., . . . Rothen Rutishauser, B. (2010). Recent advances into understanding some aspects of the structure and function of mammalian and avian lungs. Physiological and Biochemical Zoology, 83(5), 792-807.
DOI Scopus26 WoS27 Europe PMC17
2010 Orgeig, S., & Morrison, J. L. (2010). Does the intrauterine growth-restricted fetus benefit from antenatal glucocorticoids. Expert reviews in obstetrics and gynecology, 5(2), 149-152.
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2010 Orgeig, S., Hiemstra, P. S., Veldhuizen, E. J. A., Casals, C., Clark, H. W., Haczku, A., . . . Possmayer, F. (2010). Recent advances in alveolar biology : evolution and function of alveolar proteins. Respiratory physiology and neurobiology, 173(S1), S43-S54.
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2010 Torday, J., Powell, F. L., Farmer, C. G., Orgeig, S., Nielsen, H. C., & Hall, A. J. (2010). Leptin integrates vertebrate evolution : from oxygen to the blood-gas barrier. Respiratory physiology and neurobiology, 173(S1), 37-42.
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2010 Panda, A., Vasilev, K. A., Orgeig, S., & Prestidge, C. A. (2010). Thermodynamic and structural studies of mixed monolayers : mutual mixing of DPPC and DPPG with DoTAP at the air-water interface. Materials Science & Engineering C : Biomimetic & Supramolecular Systems, 30(4), 542-548.
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2009 Morrison, J. L., & Orgeig, S. (2009). Antenatal glucocorticoid treatment of the growth-restricted fetus : benefit or cost?. Reproductive sciences, 16(6), 527-538.
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2009 Dixon, D. L., De Pasquale, C. G., De Smet, H. R., Klebe, S., Orgeig, S., & Bersten, A. D. (2009). Reduced surface tension normalizes static lung mechanics in a rodent chronic heart failure model. American journal of respiratory and critical care medicine, 180(2), 181-187.
DOI Scopus28 WoS27 Europe PMC25
2007 Bernhard, W. O. L. F. G. A. N. G., Schmiedl, A., Koster, G., Orgeig, S., Acevedo, C., Poets, C., & Postle, A. (2007). Developmental changes in rat surfactant lipidomics in the context of species variability. Pediatric pulmonology.
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2007 Blacker, H., Tsopelas, C., Orgeig, S., Daniels, C. B., & Chatterton, B. (2007). How Regenerating Lymphatics Function: Lessons From Lizard Tails. Anatomical record.
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2007 Orgeig, S., Bernhard, W., Biswas, S., Daniels, C., Hall, S., Hetz, S., . . . Yan, W. (2007). The anatomy physics and physiology of gas exchange surfaces: is there a universal function for pulmonary surfactant in animal respiratory structures?. Integrative and Comparative Biology, 47(4), 610-627.
DOI Scopus40 WoS36 Europe PMC24
2007 Potter, S., Orgeig, S., Donnellan, S., & Daniels, C. (2007). Purifying selection drives the evolution of surfactant protein C (SP-C) independently of body temperature regulation in mammals. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2 PART D(2), 165-176.
DOI Scopus5 WoS6 Europe PMC3
2007 Foot, N., Orgeig, S., Donnellan, S., Bertozzi, T., & Daniels, C. (2007). Positive selection in the N-Terminal extramembrane domain of lung surfactant protein C (SP-C) in marine mammals. Journal of Molecular Evolution, 65(1), 12-22.
DOI Scopus19 WoS20 Europe PMC12
2007 Blacker, H., Tsopelas, C., Orgeig, S., Daniels, C., & Chatterton, B. (2007). How regenerating lymphatics function: Lessons from lizard tails. The Anatomical Record. Part B: The New Anatomist, 290(1), 108-114.
DOI Scopus9 WoS9 Europe PMC7
2006 Miller, N., Postle, A., Orgeig, S., Koster, G., & Daniels, C. B. (2006). The composition of pulmonary surfactant from diving mammals. Respiratory physiology and neurobiology, 152(2), 152-168.
DOI WoS26 Europe PMC16
2006 Foot, N., Orgeig, S., & Daniels, C. B. (2006). The evolution of a physiological system : the pulmonary surfactant system in diving mammals. Respiratory physiology and neurobiology, 154(1-2), 118-138.
DOI Scopus40 WoS37 Europe PMC27
2006 Miller, N., Daniels, C. B., Schurch, S., Schoel, W., & Orgeig, S. (2006). The surface activity of pulmonary surfactant from diving mammals. Respiratory physiology and neurobiology, 150(2-3), 220-232.
DOI WoS23 Europe PMC18
2005 Miller, N., Postle, A., Schurch, S., Schoel, W., Daniels, C. B., & Orgeig, S. (2005). The development of the pulmonary surfactant system in California sea lions. Comparative biochemistry and physiology A -moleculary and integrative physiology, 141(2), 191-199.
DOI WoS18 Europe PMC15
2005 Lang, C., Postle, A., Orgeig, S., Possmayer, F., Bernhard, W., Panda, A., . . . Daniels, C. (2005). Dipalmitoylphosphatidylcholine is not the major surfactant phospholipid species in all mammals. American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 289(5), R1426-R1439.
DOI Scopus96 WoS87 Europe PMC69
2004 Miller, N., Daniels, C. B., Costa, D., & Orgeig, S. (2004). Control of pulmonary surfactant secretion in adult California sea lions. Biochemical and biophysical research communications, 313(3), 727-732.
DOI WoS14 Europe PMC10
2004 Blacker, H., Orgeig, S., & Daniels, C. B. (2004). Hypoxic control of the development of the surfactant system in the chicken. American journal of physiology : regulatory, integrative and comparative physiology, 287(2), R403-R410.
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2004 Daniels, C. B., Orgeig, S., Sullivan, L., Ling, N., Bennett, M., Schurch, S., . . . Brauner, C. (2004). The origin and evolution of the surfactant system in fish. Physiological and biochemical zoology, 77(5), 732-749.
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2003 Sullivan, L., Orgeig, S., & Daniels, C. B. (2003). The role of extrinsic and intrinsic factors in the evolution of the control of pulmonary surfactant maturation during development in the amniotes. Physiological and biochemical zoology, 76(3), 281-295.
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2003 Codd, J., Orgeig, S., Daniels, C. B., & Schurch, S. (2003). Alterations in surface activity of pulmonary surfactant in Gould's wattled bat during rapid arousal from torpor. Biochemical and biophysical research communications, 308(3), 463-468.
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2003 Orgeig, S., Daniels, C. B., Johnston, S., & Sullivan, L. (2003). The pattern of surfactant cholesterol during vertebrate evolution and development. Reproduction, fertility, and development, 15(1), 55-73.
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2003 Lang, C., Orgeig, S., Daniels, C., & Milsom, W. (2003). Thermal acclimation of surfactant secretion and its regulation by adrenergic and cholinergic agonists in type II cells isolated from warm-active and torpid golden-mantled ground squirrels, Spermophilus lateralis. Journal of Experimental Biology, 206(17), 3031-3041.
DOI Scopus12 WoS12 Europe PMC9
2003 Lang, C., Orgeig, S., & Daniels, C. (2003). The effect of temperature on adrenergic receptors of alveolar type II cells of a heterothermic marsupial. Biochemical and Biophysical Research Communications, 310(3), 703-709.
DOI Scopus3 WoS3 Europe PMC2
2003 Daniels, C., Lewis, B., Tsopelas, C., Munns, S., Orgeig, S., Baldwin, M., . . . Cooter, R. (2003). Regenerating lizard tails: a new model for investigating lymphangiogenesis. FASEB Journal, 17(3), 479-481.
DOI WoS23 Europe PMC18
2003 Daniels, C. B., Lewis, B. C., Tsopelas, C., Munns, S. L., Orgeig, S., Baldwin, M. E., . . . Cooter, R. D. (2003). Regenerating lizard tails: a new model for investigating lymphangiogenesis.. FASEB Journal Official Publication of the Federation of American Societies for Experimental Biology, 17(3), 479-481.
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2002 Johnston, S., Starrs, A., Daniels, C. B., & Orgeig, S. (2002). Ontogeny of the pulmonary surfactant and antioxidant enzyme systems in the viviparous lizard, Tiliqua rugosa. Physiological and biochemical zoology, 75(3), 260-272.
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2002 Codd, J., Schurch, S., Daniels, C. B., & Orgeig, S. (2002). Torpor-associated fluctuations in surfactant activity in Gould's wattled bat. Biochimica et biophysica acta -molecular and cell biology of lipids, 1580(1), 57-66.
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2002 Sullivan, L., Orgeig, S., & Daniels, C. B. (2002). Regulation of pulmonary surfactant secretion in the developing lizard, Pogona vitticeps. Comparative biochemistry and physiology A-molecular and integrative physiology.
2002 Johnston, S., Daniels, C. B., Cenzato, D., whitsett, J., & Orgeig, S. (2002). The pulmonary surfactant system matures upon pipping in the freshwater turtle, Chelydra serpentina. Journal of experimental biology.
2002 Shepherdley, C., Daniels, C. B., Orgeig, S., Richardson, S., Evans, B., & Darras, V. (2002). Regulation of thyroid hormone function during development in the crocodile, Crocodylus porosus. American journal of physiology: regulatory, integrative and comparative physiology.
2002 Sullivan, L., Orgeig, S., & Daniels, C. B. (2002). Control of the development of the pulmonary surfactant system in the saltwater crocodile, Crocodylus porosus. American journal of physiology-Regulatory integrative and comparative physiology, 283(5), 1164-1176.
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2002 Shepherdley, C. A., Daniels, C. B., Orgeig, S., Richardson, S. J., Evans, B. K., & Darras, V. M. (2002). Glucocorticoids, thyroid hormones, and iodothyronine deiodinases in embryonic saltwater crocodiles. American journal of physiology -Regulatory integrative and comparative physiology, 283(5), 1155-1163.
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2001 Sullivan, L., & Orgeig, S. (2001). Dexamethasone and epinephrine stimulate surfactant secretion in type II cells of embryonic chickens. American Journal of Physiology - Regulatory Integrative and Comparative Physiology.
2001 Daniels, C. B., & Orgeig, S. (2001). The comparative biology of pulmonary surfactant: past, present and future. Comparative biochemistry and physiology A, 129(1), 9-36.
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2001 Orgeig, S., & Daniels, C. B. (2001). The roles of cholesterol in pulmonary surfactants: insights from comparative and evolutionary studies. Comparative biochemistry and physiology A, 129(1), 75-89.
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2001 Sullivan, L., Orgeig, S., Wood, P., & Daniels, C. B. (2001). The ontogeny of pulmonary surfactant secretion in the embryonic green sea turtle (Chelonia mydas). Physiological and biochemical zoology, 74(4), 493-501.
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2001 Daniels, C. B., Orgeig, S., & Smits, A. (2001). Surfactant, lungs and the evolution of airbreathing: A tribute to R.E. Pattle. Comparative biochemistry and physiology A, 129(1), 1-2.
DOI
2001 Starrs, A., Orgeig, S., Daniels, C. B., Davies, M., & Lopatko, O. (2001). Antioxidant enzymes in the developing lungs of egg-laying and metamorphosing vertebrates. Journal of Experimental Biology, 204(Pt 22), 3973-3981.
DOI Europe PMC18
2001 Starrs, A. P., Orgeig, S., Daniels, C. B., Davies, M., & Lopatko, O. V. (2001). Antioxidant enzymes in the developing lungs of egg-laying and metamorphosing vertebrates. Journal of Experimental Biology, 204(22), 3973-3981.
Scopus30 WoS31
2001 Lang, C., Daniels, C., & Orgeig, S. (2001). Neurochemical and thermal control of surfactant secretion by alveolar type II cells isolated from the marsupial, Sminthopsis crassicaudata. Journal of Comparative Physiology B-Biochemical Systemic and Environmental Physiology, 171(3), 223-230.
DOI Scopus13 WoS10 Europe PMC9
2001 Miller, N., Orgeig, S., Daniels, C. B., & Baudinette, R. (2001). Postnatal development and control of the pulmonary surfactant system in the tammar wallaby Macropus eugenii. Journal of experimental biology, 204(23), 4031-4042.
DOI WoS21 Europe PMC18
1997 Wood, P., Andrew, L., Daniels, C., Orgieg, S., & Roberts, C. (1997). Autonomic control of the pulmonary surfactant system and lung compliance in the lizard. Physiological Zoology, 70(4), 444-455.
DOI Scopus21 WoS21 Europe PMC16
1994 Doyle, I. R., Jones, M. E., Barr, H. A., Orgeig, S., Crockett, A. J., Mcdonald, C. F., & Nicholas, T. E. (1994). Composition of human pulmonary surfactant varies with exercise and level of fitness. American Journal of Respiratory and Critical Care Medicine, 149(6), 1619-1627.
DOI Scopus63 WoS57 Europe PMC44

Year Citation
2024 McGillick, E. V., Morrison, J. L., Parkinson Lawrence, E. J., & Paget, T. L. (2024). The development and function of the pulmonary surfactant system in health, prematurity, and genetic disease. In Source details - Title: The Lung: Development, Aging and the Environment (pp. 159-201). UK: Academic Press.
DOI
2024 McGillick, E. V., Morrison, J. L., & Orgeig, S. (2024). Effect of environment on the developing and adult pulmonary surfactant system and in the aging lung. In Source details - Title: The Lung: Development, Aging and the Environment (pp. 505-542). UK: Academic Press.
DOI
2015 Orgeig, S., Morrison, J., & Daniels, C. B. (2015). Effect of environment and aging on the pulmonary surfactant system. In R. Harding, & K. Pinkerton (Eds.), Source details - Title: The lung: development, aging and the enivronment (2 ed., pp. 447-470). Amsterdam: Academic Press.
DOI
2009 Orgeig, S., & Daniels, C. B. (2009). Environmental selection pressures shaping the pulmonary surfactant system of adult and developing lungs. In M. L. Glass, & S. Wood (Eds.), Source details - Title: Cardio-respiratory control in vertebrates: comparative and evolutionary aspects (pp. 205-239). Heidelberg: Springer.
DOI
2006 Daniels, C. B., & Orgeig, S. (2006). Pulmonary surfactant, cell culture and tissue regeneration as models for understanding the evolution of developmental physiology. In S. Warburton (Ed.), Source details - Title: Comparative developmental physiology : contributions, tools, and trends (pp. 3-20). London: Oxford Univ Press.
2005 Lang, C., Daniels, C., & Orgeig, S. (2005). New insights into the thermal dynamics of the surfactant system from warm and cold animals. In K. Nag (Ed.), Lung Surfactant Function and Disorder (pp. 17-57). 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742: Taylor & Francis.
2004 Orgeig, S., Daniels, C. B., & Sullivan, L. C. (2004). Development of the pulmonary surfactant system. In R. Harding, K. E. Pinkerton, & C. G. Plopper (Eds.), Source details - Title: The lung: development, aging and the environment (pp. 149-167). UK: Academic Press.
DOI
2004 Orgeig, S., & Daniels, C. B. (2004). Effects of aging, disease and the environment on the adult pulmonary surfactant system. In Source details - Title: The Lung: development, aging and the environment (pp. 363-375). London: Elesevier.

Year Citation
2022 Orgeig, S., Larcombe, A., Pinniger, G., Tsioutsias, I., & Parkinson-Lawrence, E. (2022). The mucopolysaccharide (MPS) I mouse displays lung and diaphragm dysfunction. In RESPIROLOGY Vol. 27 (pp. 63-64). WILEY.
WoS1
2021 Paget, T., Parkinson-Lawrence, E., Morrison, J., & Orgeig, S. (2021). THE MUCOPOLYSACCHARIDOSIS IIIA (MPS IIIA) MOUSE HAS DECREASED GENE AND PROTEIN EXPRESSION IN SURFACTANT PROTEINS - A, -C AND -D. In RESPIROLOGY Vol. 26 (pp. 140). WILEY.
2021 Paget, T., Larcombe, A., Parkinson-Lawrence, E., & Orgeig, S. (2021). THE MUCOPOLYSACCHARIDOSIS IIIA (MPS IIIA) MOUSE DEMONSTRATES INCREASED COMPLIANCE AND AIRWAY RESISTANCE AND DECREASED TISSUE DAMPING AND ELASTICITY. In RESPIROLOGY Vol. 26 (pp. 182). WILEY.
2021 Lock, M. C., Botting, K. J., Niu, Y., Ford, S. G., Orgeig, S., Giussani, D. A., & Morrison, J. L. (2021). Dexamethasone Reduces 11β-Hydroxysteroid Dehydrogenase 1 Expression the Fetal Lung Following Hypoxic Pregnancy.. In REPRODUCTIVE SCIENCES Vol. 28 (pp. 260A). SPRINGER HEIDELBERG.
2019 Lock, M. C., Botting, K. J., Niu, Y., Ford, S. G., Orgeig, S., Giussani, D. A., & Morrison, J. L. (2019). Dexamethasone Promotes Surfactant Maturation and Hypoxia Signalling in the Fetal Lung Following Hypoxic Pregnancy.. In REPRODUCTIVE SCIENCES Vol. 26 (pp. 337A). FRANCE, Paris: SAGE PUBLICATIONS INC.
2019 Paget, T., Parkinson-Lawrence, E., Trim, P., Snel, M., & Orgeig, S. (2019). INCREASED HEPARAN SULPHATE AND DECREASED LIPIDS IN ALVEOLAR SURFACTANT OF THE MUCOPOLYSACCHARIDOSIS (MPS) IIIA MOUSE.. In RESPIROLOGY Vol. 24 (pp. 119). WILEY.
WoS1
2019 Orgeig, S., Larcombe, A., Paget, T., & Parkinson-Lawrence, E. (2019). THE MUCOPOLYSACCHARIDOSIS (MPS) IIIA MOUSE DEMONSTRATES INCREASED AIRWAYS RESISTANCE. In RESPIROLOGY Vol. 24 (pp. 99). WILEY.
2016 Orgeig, S., Syedi, N., Duplock, S., Snel, M., Hemsley, K., & Parkinson-Lawrence, E. (2016). PULMONARY LIPID STORAGE AND LUNG ULTRASTRUCTURE IN THE MUCOPOLYSACCHARIDOSIS IIIA MOUSE. In RESPIROLOGY Vol. 21 (pp. 133). WILEY-BLACKWELL.
2003 Possmayer, F., Panda, A. K., Ormond, C., Nag, K., Postle, A. D., Petersen, N. O., . . . Daniels, C. B. (2003). Atypical composition and surface molecular organization of pulmonary surfactant from active and torpid fat-tailed dunnarts. In BIOPHYSICAL JOURNAL Vol. 84 (pp. 310A). SAN ANTONIO, TEXAS: BIOPHYSICAL SOCIETY.
2003 Orgeig, S. (2003). Evolutionary developmental physiology? How does individual developmental plasticity lead to heterochrony?. In Australian Frontiers of Science 2003. Canberra, Australia: Australian Academy of Science.

Year Citation
2017 McGillick, E. V., Orgeig, S., Allison, B. J., Brain, K. L., Niu, Y., Itani, N., . . . Morrison, J. L. (2017). Chronic fetal hypoxaemia & maternal antioxidants: identifying mechanisms and treatments to improve postnatal lung structure & function in growth restricted offspring. Poster session presented at the meeting of Reproductive sciences. US: Sage Publications.
2017 Paget, T., Parkinson-Lawrence, E., Duplock, S. K., Snel, M. F., Hemsley, K., & Orgeig, S. (2017). CHANGES IN LIPID METABOLISM IN MUCOPOLYSACCHARIDOSIS (MPS) IIIA MOUSE LUNG TISSUE AND PULMONARY SURFACTANT. Poster session presented at the meeting of RESPIROLOGY. WILEY.
WoS1
2017 Orgeig, S., Paget, T., Duplock, S., Snel, M., Hemsley, K., & Parkinson Lawrence, E. (2017). Changes in lipid metabolism in mucopolysaccharidosis (MPS) IIIA mouse lung tissue and pulmonary surfactant. Poster session presented at the meeting of European respiratory journal : ERS International Congress 2017 abstracts. Switzerland: European Respiratory Society.
DOI WoS1
2016 Hodge, G., Hodge, S., Yeo, A., Nguyen, P., Hopkins, E., Holmes-Liew, C., . . . Holmes, M. (2016). BOS is associated with increased cytotoxic pro-inflammatory CD8 T and NKT-Like and NK cells in the distal airways. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, as published in Respirology. Australia: Wiley-Blackwell.
DOI
2016 McGillick, E. V., Orgeig, S., & Morrison, J. L. (2016). Understanding delayed surfactant maturation in the chronically hypoxemic intrauterine growth restricted fetus by prolyl hydroxylase domain (PHD) inhibition in late gestation... Poster session presented at the meeting of Reproductive sciences. US: Sage Publications Inc.
DOI
2016 McGillick, E. V., Orgeig, S., Allison, B. J., Brain, K. L., Niu, Y., Itani, N., . . . Morrison, J. L. (2016). Differential effect of early versus late onset chronic hypoxemia on molecular mechanisms regulating lung maturation in the late gestation fetus. Poster session presented at the meeting of Reproductive sciences. US: Sage Publications.
2016 Orgeig, S., Mcgillick, E., & Morrison, J. (2016). Regulation of lung maturation by prolyl hydroxylase domain (PHD) inhibition in the lung of the normally grown and placentally restricted foetus in late gestation. Poster session presented at the meeting of Respirology. Australia: Wiley Blackwell Publishing Asia.

  • Quantification of airway disease in MPS II mice via laboratory X-ray velocimetry, The National MPS Society (USA), 01/04/2024 - 31/03/2025

  • Lung function in a mouse model of a paediatric metabolic mouse, The Australian Lung Foundation, 01/05/2016 - 05/03/2018

Date Role Research Topic Program Degree Type Student Load Student Name
2004 - 2011 Principal Supervisor Functional Characteristics and Molecular Regulation of Lymphangiogenesis during Gecko Tail Regeneration: Evidence for the Roles of VEGF-C, VEGF-D and the Receptor VEGFR-3 Doctor of Philosophy Doctorate Part Time Mrs Helen Blacker
2001 - 2005 Principal Supervisor The Evolution of a Physiological System: The Pulmonary Surfactant System in Diving Mammals Doctor of Philosophy Doctorate Full Time Ms Natalie Foot
2000 - 2001 Co-Supervisor Biological Science - Animal Biology Master of Science Master Full Time Mr Jonathan Codd
2000 - 2004 Principal Supervisor COPING WITH THE COLD: HETEROTHERMIC MAMMALS PROVIDE A NEW PARADIGM FOR SURFACTANT COMPOSITION AND FUNCTION Doctor of Philosophy Doctorate Full Time Dr Carol Lang
1999 - 2002 Principal Supervisor The Control of Pulmonary Surfactant Development in Oviparous Amniotes Doctor of Philosophy Doctorate Full Time Ms Lucy Sullivan

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