
Professor Sandra Hodge
Internal Contract-Funded Researcher (E)
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Prof Sandra Hodge is a University of Adelaide Research Fellow and Director of Chronic Inflammatory Lung Disease Research at the Royal Adelaide Hospital and University of Adelaide. Her lab was the first to describe a failed phagocytic capacity of lung macrophages with pro-inflammatory consequences in severe, treatment refractory chronic lung diseases including COPD, cystic fibrosis and severe asthma, and in response to cigarette smoke, bushfire smoke and E-cigarette vapour. The team focus then shifted to identifying and trialing new macrophage-targeted therapies.
She has published >150-refereed manuscripts, and collaborates with industry and leading research groups across Australia and internationally. International invitations include as Drug Discovery meeting panelist, industry advisor, and member of conference-organizing committees, invited speaker and session chair. She is currently CI on The Australasian COVID-19 Trial (ASCOT), a randomised control trial that will initially test two treatments for hospitalised COVID-19 patients.
Participation in major health policy advisory groups include as TSANZ Board Director, Treasurer, and Research Committee Chair. She was awarded the title of Fellow of the Thoracic Society of Australia and New Zealand (FThorSoc).
Policy advisory roles include TSANZ Position Paper writing groups, presentation to the SA Government Select Enquiry into E-cigarettes and contribution to TSANZ’s submission to the Australian Government’s inquiry into the Use and Marketing of E-Cigarettes in Australia.
She has received ~$16 mill in competitive research funding ($11.5 mill in the last 10 years, and $8 mill as CIA).
Chronic Inflammatory Lung Disease Research Lab
Our Team
We are part of the Lung Research Unit, at the Department of Thoracic Medicine at the Royal Adelaide Hospital and The University of Adelaide. Our research program largely focusses on macrophage-targeted therapeutic approaches for severe chronic lung diseases that are resistant to current therapies.
Funded collaborative projects include those in (COPD/emphysema), lung transplant rejection, steroid-resistant asthma and bronchiectasis in Indigenous children. Our multi-discipline and internationally recognised team was the first to describe failed clearance of apoptotic cells by airway macrophages (efferocytosis) in COPD that underlies the chronic inflammation and tissue damage and is not resolved with cessation of cigarette smoking once the disease is established.
We have already shown, in human clinical studies and/or murine models that several macrophage-targeted therapies including macrolide antibiotics have properties that restore airway function in this context, beyond combatting microbial infection. In a recent large randomised controlled clinical trial of the macrolide antibiotic Azithromycin (published in Thorax 2017) we and our national collaborators identified Azithromycin as a useful add-on therapy in persistent severe symptomatic asthma. However, bacterial resistance following long-term macrolide treatment necessitates new approaches, and we are now investigating new macrolides, which lack antibiotic but retain anti-inflammatory properties (in collaboration with Gilead Sciences, USA). We have recently published exciting proof-of-concept findings in the Am J Physiol.
Sandra HODGE, MSc, PhD, FThorSoc: Brief Track Record
Top manuscripts last 10yrs: All below are Q1 rated and in top 10 journals in field.
1. Landmark RCT (AMAZES) showing Azithromycin reduces asthma exacerbations by >30% over 1yr. Incorporated into latest GINA severe asthma guidelines with major implications for changes in practice. Lancet 2017, FWCI 28, PMID28687413, highly cited Q1 paper
2. New knowledge of mechanisms for colonisation of potentially pathogenic bacteria and its severe clinical manifestations in COPD, and a rationale for use of long-term Azithromycin to reduce colonisation and prevent exacerbations, Respirology 2012 PMID22288725, Featured in MDLinx and Lung Disease News, Editorial focus (Hansbro and Jarnicki), FWCI 39, in the top 25% of all research outputs scored by Altmetric Media.
3. Pioneering study with Gilead US showed that new non anti-microbial macrolides are anti-inflammatory and improve macrophage function. This approach provides an alternative to macrolides thus addresses significant concerns about anti-microbial resistance. A resultant change in drug development focus by the pharmaceutical company has progressed to pre-clinical murine studies. Am J Physiol 2017 PMID28258107
4. One of several cigarette smoke-exposed murine studies showing anti-inflammatory effects of new macrophage-targeted therapies provided mechanistic knowledge and advised a great deal of subsequent research by us and others (eg, macrolides). Am J Respir Cell Mol Biol 2011, PMID20595463 Faculty 1000 selected, FWCI 4.31
5. One of 5 from 5yr prospective cohort study that identified potential development of bronchiectasis in children with PBB, a common cause of childhood chronic cough. Incorporated into ERS taskforce paper and reviews, informing future therapy and the need for better clinical follow up of children with PBB. Chest 2016 PMID26867834.
Grants and awards: My salary, and those of my team have been 100% funded by competitive grants (>$13 million as CI), including grants from NHMRC (9 as CI), specialist agencies (Asthma Australia, ARC, Cancer Council, CellCept, TSANZ/Allan Hanbury’s, TSANZ Robert Pierce GIA for Indigenous Lung Health, ALF/Boehringer Ingelheim, Ch7 CRE, Brine Bequest, and state competitive schemes. I was awarded the Hanson Institute Early Career Researcher of the Year and the prestigious University of Adelaide Beacon Research Fellowship.
Peer Recognition: National standing is evident by appointment to NHMRC GRPs (2012-2019); GRP Co-Chair (2013), Deputy Convenor (2013-2014) and Convenor (2015-2016) of TSANZ Cell Biology and Immunology SIG, member TSANZ Education and Research Sub-committee (2012-16), Co-chair Research Sub-committee (2017-2018) and Chair (current) and invitations to chair numerous oral sessions including the Ann Woolcock YIA over several years. In 2012 I was awarded a TSANZ Silver Pin for service to the Society; in 2020 awarded a gold pin, and in 2019 appointed as a Fellow of the Society (FThorSoc). I am elected TSANZ Board Director and have served as Treasurer and member Finance and Risk Assessment Committee. I was National President of the AFCG, represented NHMRC at Science Meets Parliament, invited to the TEVA Respiratory Summit, and Australian Mucosal Immunology Group. I am current member of Registries and Clinical Trials sub-committee; Rebecca Cooper Scientific Advisory Committee; RAH Clinical Project Grant, RIBG and Research Equipment Advisory committees. I am a member and have been involved as conference organiser, speaker and Chair for 8 international societies including ATS, ISHLT, APSR/ACCP, AFCG/ASI/HLDA and numerous national societies.
Reviewing roles: 15 international; >30 national bodies/yr; NHMRC GRP 2012-19; PhD examiner 5 Aust Universities; 43 journals eg Lancet, NEJM, all top respiratory journals, invited guest-editor 5 special issues, Chief Book Editor, Editorial Board Member 3 scientific journals (currently Inflammation Research); Chair TSANZ Research Committee- objective to advise the Board on strategies for supporting research amongst members, and providing unbiased adjudication of >$1mill/year in awards.
Community: 4 clinical trials, impacting clinical practice; career advisory forums for 2ndry students as a founding member of Zonta Club; work experience for ~4/year 2ndry and 3rd year Biomedical Science students; represented NHMRC at ‘Science Meets Parliament’ raising awareness of COPD among parliamentarians; media releases (24 since 2012) and feature in ‘The Limbic’, Spanish ‘Muy Interesante’ and Boehringer booklet ‘Where are they now?’ as one of 12 top Australian researchers in my field raised community awareness of my research.
Membership of major health policy advisory groups and translation into policy / practice
As TSANZ Board Director contributed to five position papers, three guidelines; two current position paper writing groups and submission to 2018 Federal Government Inquiry into E-cigarettes; consulted by Government as witness for the 2017 SA Government Select Inquiry into E-cigarettes (resultant changes to legislation); contributed to 2012 Lung Health Alliance Submission for Strategic Review of Health and Medical Research; invited Pharmaceutical Company Advisor (GlaxoSmithKline R&D 2006; AstraZeneca R&D Sweden 2015). Clinical trial involvement including two with azithromycin in COPD and asthma advised better-informed use of add-on macrolide therapies in chronic lung diseases and likely incorporation into International clinical guidelines. With Gilead USA our current investigations of non-antimicrobial macrolides are addressing the global priority of halting the generation of further antibiotic resistant bacteria.
International collaborations/ interactions with pharmaceuticals companies: My expertise and models of COPD and other chronic inflammatory lung are now internationally sought after and several of our discoveries have been the subject of national electronic and print media news. Collaborations include Aust. Red Cross Blood Service, AstraZeneca R&D, Advisor (2011-2012), GlaxoSmithkline (USA) COPD Drug Discovery group; (2008), Universities of Duisburg-Essen Germany, Tabuk, Saudi Arabia and Gothenburg Sweden, National Research Institute on Food & Nutrition Italy, Imperial College London, Gilead Sciences USA, Universitätsmedizin Berlin and amilitary Hospital 175, Vietnam.
Selected invitations to speak at major international conferences (*fully funded):
- 2019 Combined Respiratory Society of Vietnam and University of Medical Sciences, Ho Chi Minh City (Symposium Plenary speaker)*.
- 2018 Le Centre Hospitalier Universitaire Vaudois Switzerland (Invited speaker).
- 2018 Asthma and Respiratory Foundation New Zealand (Plenary 1. Keynote speaker)*.
- 2018 Asthma and Respiratory Foundation New Zealand (Plenary 2. Panel member)*.
- 2015 Amgen USA (Invited speaker).
- 2014 Université de Lausanne, Switzerland (Symposium Plenary speaker).
- 2013 Le Centre Hospitalier Universitaire Vaudois Switzerland (Plenary speaker).
- 2011 Int Lectin Society (Symposium keynote speaker) *.
- 2010 American Thoracic Society (ATS) (Symposium keynote speaker*).
- 2009 National Jewish Medical Research, Denver, USA* (Visiting Professor and plenary speaker).
- 2009 University of Denver, USA* (Symposium Plenary speaker).
- 2008 GlaxoSmithkline (USA) COPD Drug Discovery group* (Panel member).
- 2010 ATS New Orleans 2010 Oral Cell Biology Session, (Panel member).
- 2007 12th Congress of APSR/2nd Joint Congress of the APSR/ACCP, Australia (Invited speaker).
- 2004 Federation of Immunological Societies of Asia-Oceania (FIMSA) (Workshop facilitator).
Current research programs include:
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Macrophage-targeted therapies in chronic inflammatory lung diseases
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LC3-associated phagocytosis: common target in COPD and cancer pathogenesis
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Sphingosine-1 phosphate signalling – novel mediator of vascular dysfunction in children with cystic fibrosis
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Zinc influx regulates autophagy and pro-constrictive changes in microvascular cells
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Pulmonary hypertension and its therapeutic targeting in cystic fibrosis
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Role of endothelin-1 signalling by neutrophils in cystic fibrosis-associated pulmonary hypertension
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Multiple inflammasome activation in chronic lung diseases
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Ex vivo models of accelerated cell aging in translation to senotherapy in COPD
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Role of LC3-associated phagocytosis in tumour reccurrence following cytotoxic anti-tumour treatment
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Research funding acknowledgements
The National Health and Medical Research Council, Thoracic Society of Australia and New Zealand, Lung Foundation Australia, Royal Adelaide Hospital, Channel 7 Children’s Research Foundation, Cystic Fibrosis Foundation, and the University of Adelaide.
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Appointments
Date Position Institution name 2020 - 2020 Professorial Research Fellow The University of Adelaide 2017 - 2019 Beacon Professorial Research Fellow The University of Adelaide 2010 - ongoing Head Chronic Inflammatory Lung Disease Research Lab Royal Adelaide Hospital, Adelaide -
Awards and Achievements
Date Type Title Institution Name Country Amount 2018 Distinction Treasurer, Thoracic Society of Australia and New Zealand Treasurer, Thoracic Society of Australia and New Zealand Australia 2018 Invitation Writing Group Member: TSANZ Position Paper: Electronic Nicotine (and non-nicotine) Delivery Systems TSANZ Position Paper: Electronic Nicotine (and non-nicotine) Delivery Systems Australia 2018 Invitation Writing Group Member: TSANZ Position Paper Alpha-1 Antitrypsin deficiency writing group TSANZ Australia 2018 Nomination NHMRC Grant Review Panel NHMRC Australia 2018 Invitation Chair and Judge, Anne Woolcock New Investigator Award Thoracic Society of Australia and New Zealand Australia 2017 Award International Travel Award TSANZ/Menarini Australia 3,000 2017 Invitation Grand Round Presentation Royal Adelaide Hospital Australia 2017 Invitation Keynote speaker Thoracic Society of Australia and New Zealand Australia 2017 Award COPD Research Award Boehringer Ingelheim/ TSANZ Australia 2017 Award University Professorial Research Fellow (E) The University of Adelaide Australia 2017 Distinction Co-Chair Research Sub-Committee Thoracic Society of Australia and New Zealand Australia 2017 Invitation Invoited Chair, International Meeting Asia Pacific Society for Respirology Australia 2017 Award International Research Travel Award Lung Foundation Australia/ A. Menarini Australia Australia 2017 Invitation Invited presenter, SA Government Select Enquiry into E-cigarettes SA Government Australia 2017 Invitation Judge, TSANZ 50th Anniversary Benevolent Grant Thoracic Society of Australia and New Zealand Australia 2017 Invitation Invited Grand Round Presenter, Royal Adelaide Hospital Royal Adelaide Hospital Australia 2017 Invitation Contributer, TSANZ submission to Australian Government Inquiry into the Use and Marketing of Electronic Cigarettes and Personal Vaporisers in Australia Australian Federal Government Australia 2016 Award TSANZ/Robert Pierce Award for Indigenous Lung Health Research 2014 Achievement Expert Guide Australia: Expert in Medicine/ Medical Research Category Asthma 2013 Award TSANZ/Robert Pierce Award for Indigenous Lung Health Research 2012 Award TSANZ Award of Silver Pin for service to the Society -
Education
Date Institution name Country Title The University of Adelaide Australia PhD University of South Australia Australia MSc University of South Australia Australia Diploma in Applied and Visual Art University of South Australia Australia Diploma in Biomedical Science -
Postgraduate Training
Date Title Institution Country 2020 Finance for the Non Financial Manager University of Sydney Australia -
Research Interests
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Journals
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Books
Year Citation 2009 Hodge, S. (2009). Lung Macrophages in health and disease. BENTHAM SCIENCE PUBLISHERS.
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Book Chapters
Year Citation 2018 Hodge, G. L., & Hodge, S. J. (2018). Steroid resistant CD8⁺CD28null NKT-like pro-inflammatory cytotoxic cells in chronic obstructive pulmonary disease. In F. A. Arosa (Ed.), On the Origin and Function of Human NK-like CD8+ T Cells: Charting New Territories (pp. 67-73). Frontiers Media SA.
2015 Hodge, S., & Hodge, G. (2015). Evasion of cytotoxic lymphocyte and pulmonary macrophage mediated immune responses in lung cancer. In Ed B Bonavida (Ed.), Resistance of Targeted Anti-Cancer Therapeutics. Online: Springer. 2011 Hodge, G., Hodge, S., Reynolds, P., & Holmes, M. (2011). Measurement of intracellular cytokines to improve therapeutic monitoring of immunosuppressive drugs following lung transplantation. In Lung Transplantation: Therapies, Complications and Outcomes (pp. 177-211). 2011 Hodge, G., Hodge, S., Reynolds, P., Chambers, D., & Holmes, M. (2011). Leucocyte intracellular cytokines in lung transplant patients - A more physiological indicator of immunosuppression than plasma drug levels. In Lung Transplantation: Therapies, Complications and Outcomes (pp. 147-176). 2009 hodge, S. (2009). Book Forward. In S. J. Hodge (Ed.), Lung Macrophages in Health and Disease. Bentham Science Publishers. 2009 hodge, S. (2009). Book Forward. In S. J. Hodge (Ed.), Lung Macrophages in Health and Disease. Bentham Science Publishers. 2009 Hodge, S. J. (2009). Leucocyte intracellular cytokines in lung transplant patients- a more physiological indicator of immunosuppression than plasma drug levels. In C. taylor (Ed.), Immunosuppression: New Research (pp. 91-115). 2009 Hodge, S. J. (2009). Defective clearance of apoptotic cells (efferocytosis). In S. J. Hodge (Ed.), Lung Macrophages in Health and Chronic Disease. Bentham. 2009 Hodge, S. J. (2009). Defective clearance of apoptotic cells (efferocytosis). In S. J. Hodge (Ed.), Lung Macrophages in Health and Chronic Disease. Bentham. 2009 Hodge, S. (2009). Defective clearance of apoptotic cells (efferocytosis) in chronic lung diseases. In Lung Macrophages in Health and Disease (pp. 62-75). BENTHAM SCIENCE PUBLISHERS.
2009 Reynolds, P., & Hodge, S. (2009). The impact of defective clearance of apoptotic cells in the pathogenesis of chronic lung diseases: chronic obstructive pulmonary disease, asthma and cystic fibrosis. In D. Krysko, & P. Vandenabeele (Eds.), Phagocytosis of Dying Cells: From Molecular Mechanisms to Human Disease (pp. 393-408). The Netherlands: Springer.
Scopus22008 Hodge, S. J. (2008). New Apoptosis Research in Respiratory Disease. In R. fenton (Ed.), Cell Apoptosis Research Progress. Nova Science Publishers. 2007 Hodge, G., Hodge, S., Reynolds, P., & Holmes, M. (2007). Measurement of Intracellular Cytokines to improve Therapeutic Monitoring of Immunosuppressive Drugs following Lung Transplantation. In O. Ulricker (Ed.), Transplantation Immunology Research Trends (pp. 111-146). New York: Nova Science Publishers. -
Conference Papers
Year Citation 2018 Ween, M., Whittall, J., Tran, H., & Hodge, S. (2018). Investigation of Cigarette Smoke Oxidised Lipids on Macrophages. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 197 (pp. 1 page). San Diego, CA: AMER THORACIC SOC. 2017 Hodge, G., Hodge, S., Holmes-Liew, C., Reynolds, P., & Holmes, M. (2017). Histone deacetylase 2 is decreased in peripheral blood pro-inflammatory CD8+ T and NKT-like lymphocytes following lung transplant. In Respirology Vol. 22 (pp. 394-400). Australia: WILEY-BLACKWELL.
Scopus4 WoS4 Europe PMC42015 Simpson, J., Yang, I., Upham, J., Reynolds, P., Hodge, S., James, A., . . . Gibson, P. (2015). Sputum And Serum Periostin Levels Are Associated With, But Do Not Predict Sputum Eosinophil Proportion In Severe Asthma. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 191 (pp. 1 page). Denver, CO: AMER THORACIC SOC.
WoS12011 Hodge, G., Hodge, S., Chambers, D., Hopkins, P., Reynolds, P. N., Holmes, M., & Liew, C. -L. (2011). BOS Is Associated with Increased Expression of C4d on Airway Bronchial Epithelial Cells Using Flow Cytometry - Potential Use in Diagnosing AMR. In JOURNAL OF HEART AND LUNG TRANSPLANTATION Vol. 30 (pp. S56-S57). San Diego, CA: ELSEVIER SCIENCE INC.
2011 Hodge, S., Dean, M., Hodge, G., Holmes, M., & Reynolds, P. N. (2011). Decreased Efferocytosis (Phagocytosis of Apoptotic Cells) and Mannose Binding Lectin in the Airways of Patients with Bronchiolitis Obliterans Syndrome. In JOURNAL OF HEART AND LUNG TRANSPLANTATION Vol. 30 (pp. S119). San Diego, CA: ELSEVIER SCIENCE INC.
2010 Chambers, D. C., Hodge, S., Hodge, G., Kermeen, F., Reynolds, P., Holmes, M., & Hopkins, P. (2010). A Novel Approach to the Assessment of Lymphocytic Bronchiolitis - The 'B Score'. In JOURNAL OF HEART AND LUNG TRANSPLANTATION Vol. 29 (pp. S102). Chicago, IL: ELSEVIER SCIENCE INC.
2010 Liew, C. -L., Hodge, G., Hodge, S., Chambers, D., Hopkins, P., Reynolds, P. N., & Holmes, M. D. (2010). Lymphocytic Bronchiolitis Is Associated with Inadequate Suppression of Blood T-Cell Granzyme B, IFN gamma and TNF alpha. In JOURNAL OF HEART AND LUNG TRANSPLANTATION Vol. 29 (pp. S101). Chicago, IL: ELSEVIER SCIENCE INC.
2009 Hodge, S., Hodge, G., Ahern, J., Nairn, J., Liew, C. -L., Reynolds, P. N., . . . Holmes, M. (2009). Increased Levels of T-Cell Granzyme b in Bronchiolitis Obliterans Syndrome (BOS) Are Not Adequately Suppressed by Current Immunosuppressive Regimens. In JOURNAL OF HEART AND LUNG TRANSPLANTATION Vol. 28 (pp. S172). Paris, FRANCE: ELSEVIER SCIENCE INC.
2009 Chambers, D. C., Hopkins, P. M. A., Kermeen, F., Abern, J., Hodge, G., Reynolds, P., . . . Hodge, S. (2009). Mucosal Integrin Expressing CD8 Lymphocytes infiltrate Small Airways during Episodes of Acute Lung Allograft Rejection - Link between Rejection and BOS?. In JOURNAL OF HEART AND LUNG TRANSPLANTATION Vol. 28 (pp. S138-S139). Paris, FRANCE: ELSEVIER SCIENCE INC.
2008 Hodge, S., Holmes, M., Banerjee, B., Waterer, G., Reynolds, P., Hodge, G., & Cbambers, D. C. (2008). Epithelial to mesenchymal transition (EMT) as an indicator of airway wall remodelling in lung transplant patients. In JOURNAL OF HEART AND LUNG TRANSPLANTATION Vol. 27 (pp. S250). Boston, MA: ELSEVIER SCIENCE INC.
2005 Hodge, S., Hodge, G., Jersmann, H., Holmes, M., & Reynolds, P. (2005). Azithromycin increases phagocytosis of apoptotic airway epithelial cells by alveolar macrophages in vitro. In European Respiratory Journal Vol. 26 (pp. 20s). Copenhagen, Denmark: European Respiratory Society. 2004 Finan, K., Hodge, G., Reynolds, A., Hodge, S., Holmes, M., Baker, A., & Reynolds, P. (2004). Delivery of tissue inhibitor of metalloproteinase 3 inhibits growth of lung cancer tumours in vivo. In MOLECULAR THERAPY Vol. 9 (pp. S364). Minneapolis, MN: ACADEMIC PRESS INC ELSEVIER SCIENCE. 2004 Hodge, G., Hodge, S., Haslam, R., McPhee, A., Sepulveda, H., Morgan, E., . . . Zola, H. (2004). Rapid detection of neonatal sepsis by simultaneous measurment of multiple cytokines using 100 mu L sample volumes. In CYTOMETRY PART A Vol. 59A (pp. 108-109). Montpellier, FRANCE: WILEY-LISS. 2003 Finan, K., Hodge, G., Reynolds, A., Hodge, S., Holmes, M., Baker, A., & Reynolds, P. (2003). Over-expression of TIMP 3 causes apoptosis in lung cancer cells. In JOURNAL OF GENE MEDICINE Vol. 5 (pp. S18). QUEENSLAND INST MED RES BRISBANE, BRISBANE, AUSTRALIA: JOHN WILEY & SONS LTD. 2003 Finan, K., Hodge, G., Reynolds, A., Hodge, S., Holmes, M., Baker, A., & Reynolds, P. (2003). Over-expression of TIMP-3 causes apoptosis in lung cancer cells. In MOLECULAR THERAPY Vol. 7 (pp. S287). WASHINGTON, D.C.: ACADEMIC PRESS INC ELSEVIER SCIENCE. -
Conference Items
Year Citation 2021 Asare, P. F., Tran, H. B., Hurtado, P. R., Perkins, G. B., Nguyen, P., Jersmann, H., . . . Hodge, S. (2021). Inhibition of LC3-associated phagocytosis in COPD and in response to cigarette smoke. Poster session presented at the meeting of Therapeutic Advances in Respiratory Disease. England: SAGE PUBLICATIONS LTD.
2019 Tran, H. B., Macowan, M., Abdo, A., Donnelley, M., Parsons, D., & Hodge, S. (2019). Airway inflammasome activation and dysregulated S1P signalling associated with mucus obstruction in a cystic fibrosis-like mouse model.. Poster session presented at the meeting of Respirology. Wiley. 2019 Ween, M. P., Bastian, N. A., Thredgold, L., Reynolds, P. N., & Hodge, S. J. (2019). DEVICE, FLAVOUR, AND COIL TEMPERATURE IN AN E-CIGARETTE ALL CONTRIBUTE TO VIABILITY OF PRIMARY BRONCHIAL EPITHELIAL CELLS AND EFFEROCYTOSIS OF APOPTOTIC BRONCHIAL CELLS BY MACROPHAGES. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2018 Hodge, G., Jersmann, H., Holmes, M., Reynolds, P., & Hodge, S. (2018). LYMPHOCYTE SENESCENCE IN COPD IS ASSOCIATED WITH DECREASED SIRT1 EXPRESSION IN STEROID RESISTANT PRO-INFLAMMATORY LYMPHOCYTES. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2018 Hodge, G., Hodge, S., Nguyen, P., Yeo, A., Sarkar, P., Badiei, A., . . . Holmes, M. (2018). Bronchiolitis obliterans syndrome is associated with increased p-glycoprotein expression and loss of glucocorticoid receptor from steroid resistant pro-inflammatory CD8+T cells. Poster session presented at the meeting of Abstracts of the 22nd Congress of the Asian Pacific Society of Respirology, as published in Respirology. Sydney, Australia: Wiley-Blackwell.
2017 Gibson, P., Yang, I., Upham, J., Reynolds, P., Hodge, S., James, A., . . . Simpson, J. (2017). Azithromycin reduces exacerbations in adults with persistent symptomatic eosinophilic asthma. Poster session presented at the meeting of TSANZ oral presentations, as published in Respirology. Canberra, ACT: Wiley.
WoS12017 Powell, H., Simpson, J., Yang, I., Upham, J., Reynolds, P., Hodge, S., . . . Gibson, P. (2017). An analysis of the effect of azithromycin in persistent asthma, based on pre-specified asthma phenotypes. Poster session presented at the meeting of TSANZ poster presentations, as published in Respirology. Canberra, ACT: Wiley. 2017 Hodge, G., Hodge, S., Yeo, A., Phan, N., Hopkins, E., Holmes-Liew, C. -L., . . . Holmes, M. (2017). REDUCED GCR, HDAC2 AND HSP90 IN PRO-INFLAMMATORY LYMPHOCYTES IN THE SMALL AIRWAYS DURING BOS. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2017 Tran, H. B., Hamon, R., Truong, T. T., Ween, M., Riscioli, E., Jerssman, H., . . . Hodge, S. (2017). CIGARETTE SMOKE-INDUCED INFLAMMATION IN MACROPHAGES IS INITIATED BY NLRP3/AIM2 INFLAMMASOMES: INVOLVEMENT OF THE SPHINGOSINE-1-PHOSPHATE (S1P) SIGNALLING. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2017 Hamon, R., Hai, T., Roscioli, E., Jersmann, H., Reynolds, P., Wilbert, S., & Hodge, S. (2017). Non-antibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases. Poster session presented at the meeting of Proceedings of The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ)Annual Scientific Meeting, 2017, as published in Respirology. Canberra, ACT: Wiley. 2017 Hodge, G., Jersmann, H., Holmes, M., Reynolds, P., & Hodge, S. (2017). Steroid resistant CD8+CD28(null) NKT-like pro-inflammatory cytotoxic cells in COPD. Poster session presented at the meeting of Proceedings of The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ)Annual Scientific Meeting, 2017, as published in Respirology. Canberra, ACT: Wiley. 2017 Roscioli, E., Bac-Tran, H., Jersmann, H., Hodge, G., Hopkins, E., Hamon, R., . . . Hodge, S. (2017). Zinc dyshomeostasis and autophagy as critical determinants for airway epithelial dysfunction in COPD. Poster session presented at the meeting of Proceedings of The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ)Annual Scientific Meeting, 2017, as published in Respirology. Canberra, ACT: Wiley. 2017 Ween, M., Jones, C., Tran, H., Whittall, J., & Hodge, S. (2017). Investigation of the CD1b lipid antigen presentation pathway In pulmonary COPD. Poster session presented at the meeting of Abstracts of The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting 2017, as published in Respirology. Canberra, Australia: Wiley.
2017 Whittall, J., Ween, M., & Hodge, S. (2017). Innate immune macrophage response to NTHi and azithromycin in COPD. Poster session presented at the meeting of Abstracts of The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting 2017, as published in Respirology. Canberra, Australia: Wiley.
2017 Ween, M., Whittall, J., & Hodge, S. (2017). E-CIGARETTES CAUSE INCREASED CELL DEATH, APOPTOSIS AND ALTERED CYTOKINE PROFILE OF HUMAN BRONCHIAL EPITHELIAL CELLS. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2016 Tran, H., Rhys, H., Ween, M., Hodge, G., Barnawi, J., Reynolds, P., . . . Hodge, S. (2016). SPNS2 IN THE AIRWAY EPITHELIAL CELLS AND ALVEOLAR MACROPHAGES CONTRIBUTES DIFFERENTLY INTO CIGARETTE-NDUCED DEREGULATED S1P SIGNALING: A TRANSLATION TO THE MECHANISM OF COPD. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2016 Tran, H., Hamon, R., Roscioli, E., Ween, M., Hodge, G., Jersmann, H., . . . Hodge, S. (2016). CIGARETTE SMOKE INDUCED MULTIPLE INFLAMMASOME ACTIVATION AND ANTI-INFLAMMATORY EFFECTS OF S1P AND FTY720 SUGGEST NOVEL TARGETS IN COPD. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2016 Roscioli, E., Bac-Tran, H., Hamon, R., Zalewski, P., & Hodge, S. J. (2016). Association Of Increased Autophagy In COPD And Dysregulation Of Zinc Handling Systems. Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. San Francisco, CA: AMER THORACIC SOC. 2016 Rogers, G. B., Leong, L. E., Gibson, P. G., Yang, I. A., Hodge, S. J., Reynolds, P. N., . . . Simpsons, J. L. (2016). The Lung Microbiota In Stable Adult Asthma Differs According To Inflammatory Phenotype, Sex, And Atopy. Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. San Francisco, CA: AMER THORACIC SOC. 2016 Ween, M., Hodge, G., Reynolds, P., & Hodge, S. (2016). The new kid on the block: e-cigarettes can cause damage to airway cells and cause airway macrophage dysfunction. Poster session presented at the meeting of Abstract of the 2016 International Conference of the American Thoracic Society, as published in American Journal of Respiratory and Critical Care Medicine. San Francisco, CA: American Thoracic Society.
WoS22016 Leong, L., Rogers, G., Gibson, P., Yang, I., Reynolds, P., Hodge, S., . . . Simpson, J. (2016). THE LUNG MICROBIOTA IN STABLE ADULT ASTHMA DIFFERS ACCORDING TO INFLAMMATORY PHENOTYPE. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2016 Simpson, J., Powell, H., Yang, I., Upham, J., Reynolds, P., Hodge, S., . . . Gibson, P. (2016). SPUTUM INFLAMMATORY PHENOTYPES IN SYMPTOMATIC ASTHMA AROUND AUSTRALIA. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2016 Tran, H., Barnawi, J., Ween, M., Hamon, R., Roscioli, E., Hodge, G., . . . Hodge, S. (2016). CHANGED INTRACELLULAR LOCALIZATION OF SPHINGOSINE KINASES BY CIGARETTE SMOKE IN MACROPHAGES MAY CONTRIBUTE TO DEFECTIVE PHAGOCYTIC FUNCTION. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2016 Ween, M., Hodge, G., Reynolds, P., & Hodge, S. (2016). The new kid on the block: e-cigarettes can cause damage to airway cells and cause airway macrophage dysfunction. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2016 Annual Scientific Meetings, as published in Respirology. Perth, Western Australia: Wiley.
2016 Tran, H., Hamon, R., Ween, M., Hodge, G., Roscioli, E., Barnawi, J., . . . Hodge, S. (2016). DIFFERENTIAL SUBCELLULAR LOCALIZATION AND EXPRESSION OF SPINSTER HOMOLOG 2 (DROSOPHILA) IN AIRWAY EPITHELIAL CELLS AND MACROPHAGES IN RESPONSE TO CIGARETTE SMOKE AND IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE MAY CONTRIBUTE TO MACROPHAGE PHAGOCYTIC DYSFUNCTION. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2016 Roscioli, E., Bac-Tran, H., Hamon, R., Zalewski, P., Hodge, G., Reynolds, P., & Hodge, S. (2016). AUTOPHAGY-RELATED EPITHELIAL DISINTEGRATION IN AN EX VIVO MODEL OF COPD. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2016 Hamon, R., Roscioli, E., Jersmann, H., & Hodge, S. (2016). BUSHFIRE SMOKE AND ITS EFFECTS ON AIRWAY CELLS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2016 Hodge, G., Hodge, S., Yeo, A., Nguyen, P., Hopkins, E., Holmes-Liew, C., . . . Holmes, M. (2016). BOS is associated with increased cytotoxic pro-inflammatory CD8 T and NKT-Like and NK cells in the distal airways. Poster session presented at the meeting of Abstracts of the 36th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), as published in Journal of Heart and Lung Transplantation. Washington, DC: Elsevier.
2016 Hodge, G., Hodge, S., Yeo, A., Nguyen, P., Hopkins, E., Holmes-Liew, C., . . . Holmes, M. (2016). BOS is associated with increased cytotoxic pro-inflammatory CD8 T and NKT-Like and NK cells in the distal airways. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, as published in Respirology. Perth, WA: Wiley-Blackwell.
2016 Hodge, G., Jersman, H., Holmes, M., Roscioli, E., Tran, H., Reynolds, P., & Hodge, S. (2016). STEROID RESISTANCE IN COPD IS ASSOCIATED WITH IMPAIRED MOLECULAR CHAPERONE HSP90 EXPRESSION BY PRO-INFLAMMATORY LYMPHOCYTES. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2015 Hodge, G., Hodge, S., Holmes-Liew, C., Reynolds, P., & Holmes, M. (2015). HISTONE DEACETYLASE 2 IS DECREASED IN PERIPHERAL BLOOD CYTOTOXIC/PRO-INFLAMMATORY CD8+T AND NKT-LIKE LYMPHOCYTES FOLLOWING LUNG TRANSPLANT. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL. 2015 Upham, J., Chen, A., Carroll, M., Petsky, H., Pizzutto, S., Yerkovich, S., . . . Chang, A. (2015). IMMUNE RESPONSES TO NONTYPEABLE HAEMOPHILUS INFLUENZAE IN PROTRACTED BACTERIAL BRONCHITIS. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL.
WoS22015 Tran, H., Zalewski, P., Roscioli, E., Barnawi, J., Hodge, G., Reynolds, P., & Hodge, S. (2015). ZINC DYSHOMEOSTASIS IS LINKED TO DEFECTIVE LUNG MACROPHAGE PHAGOCYTIC FUNCTION AND AIRWAY INFLAMMATION IN MICE EXPOSED TO CIGARETTE SMOKE. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL. 2015 Roscioli, E., Tran, H., Zalewski, P., Hodge, G., Carrol, A., Rix, S., . . . Hodge, S. (2015). ZINC HANDLING SYSTEM AND AUTOPHAGY IN COPD. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL. 2015 Roscioli, E., Hamon, R., Ruffin, R., Zalewski, P., Hodge, S., Grant, J., & Lester, S. (2015). BIRC2 SINGLE NUCLEOTIDE POLYMORPHISMS MODULATE THE SEVERITY OF ASTHMA IN A CAUCASIAN COMMUNITY-BASED COHORT. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL. 2015 Carroll, A., Rix, S., Tran, H., Barnawi, J., Hodge, G., Pitson, S., . . . Hodge, S. (2015). PULMONARY MACROPHAGE EFFEROCYTOSIS IN COPD IS SUPPRESSED BY DISTURBANCES TO FEEDBACK MECHANISMS IN SPHINGOSINE 1 PHOSPHATE SIGNALLING AND REVERSED WITH FTY720. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL. 2015 Carroll, A., Rix, S., Ahern, J., Hodge, G., Pizzuto, S., Jersmann, H., . . . Hodge, S. (2015). A SMALL VOLUME TECHNIQUE TO EXAMINE AND COMPARE ALVEOLAR MACROPHAGE PHAGOCYTOSIS OF APOPTOTIC CELLS AND NTHI. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL. 2015 Hodge, G., Jersmann, H., Holmes, M., Reynolds, P., & Hodge, S. (2015). LYMPHOCYTE SENESCENCE IN COPD IS ASSOCIATED WITH DECREASED HISTONE DEACETYLASE 2 EXPRESSION BY PRO-INFLAMMATORY LYMPHOCYTES. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL. 2015 Barnawi, J., Jersmann, H., Tran, H., Pitson, S., Haberberger, R., Meech, R., & Hodge, S. (2015). DIFFERENTIAL DNA METHYLATION PATTERN OF SPHINGOSINE-1 PHOSPHATE RECEPTOR 5 IN ALVEOLAR MACROPHAGES IN COPD - POTENTIAL LINK TO FAILED EFFEROCYTOSIS?. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL. 2014 Hodge, G., Jersmann, H., Holmes, M., Reynolds, P., & Hodge, S. (2014). LYMPHOCYTE SENESCENCE IN COPD IS ASSOCIATED WITH LOSS OF GLUCOCORTICOID RECEPTOR EXPRESSION BY PRO-INFLAMMATORY/CYTOTOXIC LYMPHOCYTES. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2014 Hodge, G., Barnawi, J., Holmes, M., Jersmann, H., Reynolds, P., & Hodge, S. (2014). LUNG CANCER IS ASSOCIATED WITH DECREASED EXPRESSION OF PERFORIN, GRANZYME B AND IFNG BY INFILTRATING T CELLS, NKT-LIKE AND NK CELLS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY-BLACKWELL.
WoS12014 Barnawi, J., Holt, P., Hodge, G., Jersmann, H., Pitson, S., Haberberger, R., & Hodge, S. (2014). THERAPEUTIC MODULATION OF THE SPHINGOSINE SIGNALLING SYSTEM WITH THYMOQUININE AS A NOVEL MACROPHAGE-TARGETED TREATMENT FOR COPD. Poster session presented at the meeting of Respirology. WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: Wiley.
2014 Simpson, J., Gao, P., Baines, K., Yang, I., Reynolds, P., Hodge, S., . . . Gibson, P. (2014). GALECTIN 3 AND GALECTIN 3 BINDING PROTEIN IN ASTHMA INFLAMMATORY SUBTYPES. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2014 Hodge, G., Upham, J., Chang, A., Gibson, P., Pizzutto, S., Petsky, H., & Hodge, S. (2014). INCREASED PERIPHERAL BLOOD PRO-INFLAMMATORY/CYTOTOXIC T AND NKT-LIKE CELLS IN INDIGENOUS CHILDREN WITH BRONCHIECTASIS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2014 Tran, H., Ahern, J., Hodge, G., Holt, P., Dean, M., Reynolds, P., & Hodge, S. (2014). OXIDATIVE CHANGES TO SUB-CELLULAR LOCALIZATION AND FUNCTION OF MANNOSE BINDING LECTIN ON ALVEOLAR MACROPHAGES MAY CONTRIBUTE TO THEIR DECREASED PHAGOCYTIC FUNCTION AND INCREASED INFLAMMATION IN COPD. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2014 Simpson, J., Carroll, M., Gibson, P., Yang, I., Reynolds, P., Hodge, S., . . . Peters, M. (2014). REDUCED ANTI-VIRAL INNATE IMMUNITY IN PATIENTS WITH SEVERE ASTHMA IS ASSOCIATED WITH NEUTROPHILIC INFLAMMATION AND HIGH DOSE INHALED STEROIDS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2014 Hodge, S., Hodge, G., Pizzutto, S., Petsky, H., Gibson, P., Chang, A., & Upham, J. (2014). REDUCED MACROPHAGE PHAGOCYTIC HOST RESPONSE TO NTHI IN CHILDREN WITH BRONCHIECTASIS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL.
WoS22013 Barnawi, J., Ahern, J., Jersmann, H., Haberberger, R., & Hodge, S. (2013). CHARACTERIZATION OF THE SPHK/S1P PATHWAY IN HUMAN ALVEOLAR MACROPHAGES IN COPD AND LUNG CANCER. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2013 Hodge, G., Hodge, S., Ahern, J., Holmes-Liew, C. -L., Reynolds, P., & Holmes, M. (2013). TARGETING STEROID-RESISTANT PERIPHERAL BLOOD PRO-INFLAMMATORY CD28NULL T CELLS BY INHIBITING CD137 EXPRESSION: RELEVANCE TO TREATMENT OF BOS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2013 Hodge, G., Jersmann, H., Ahern, J., Holmes, M., Reynolds, P. N., & Hodge, S. (2013). COPD IS ASSOCIATED WITH INCREASED PGP-1 EXPRESSION IN PRO-INFLAMMATORY PERIPHERAL BLOOD T, NK AND NKT-LIKE CELLS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2013 Hodge, G., Hodge, S., Ahern, J., Holmes-Liew, C. -L., Reynolds, P. N., & Holmes, M. (2013). Targeting Steroid Resistant Peripheral Blood Pro-Inflammatory CD28null T Cells by Inhibiting CD137 Expression: Relevance to BOS. Poster session presented at the meeting of JOURNAL OF HEART AND LUNG TRANSPLANTATION. Montreal, CANADA: ELSEVIER SCIENCE INC.
WoS12013 Ahern, J., Mukaro, V., Hodge, G., Dean, M., Weiland, F., Pizzutto, S., . . . Hodge, S. (2013). Oxidative stress decreases functional airway mannose binding lectin in COPD. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, as published in Respirology. Darwin, N.T.: Wiley-Blackwell.
2013 Simpson, J. L., Yang, I. A., Reynolds, P. N., Hodge, S. J., James, A. L., Upham, J., . . . AMAZES Study. (2013). Alternatives to induced sputum for identifying patients with eosinophilic asthma. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, as published in Respirology. Darwin, N.T.: Wiley-Blackwell.
2013 Powell, H., Garside, C. G., Simpson, J. L., Yang, I. A., Reynolds, P. N., Hodge, S. J., . . . AMAZES Study Research Group. (2013). Characteristics of uncontrolled asthma in Australia. Poster session presented at the meeting of Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, as published in Respirology. Darwin, N.T.: Wiley-Blackwell.
2013 Ahern, J., Mukaro, V., Hodge, G., Reynolds, P., Dean, M., Pizzutto, S., & Hodge, S. (2013). Oxidative Stress Decreases Functional Airway Mannose Binding Lectin In COPD. Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. 2013 Hodge, G. L., Jersmann, H., Ahern, J., Holmes, M., Reynolds, P. N., & Hodge, S. (2013). COPD Is Associated With Increased Pgp-1 Expression In Pro-Inflammatory Peripheral Blood T, Nk And Nkt-Like Cells. Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC. 2012 Hodge, S., Hodge, G., Holmes-Liew, C. -L., Reynolds, P. N., & Holmes, M. (2012). BOS Is Associated with Increased Peripheral Blood NKT-Like and NK Cell Granzymes, Perforin and Th1 Pro-Inflammatory Cytokines. Poster session presented at the meeting of JOURNAL OF HEART AND LUNG TRANSPLANTATION. Prague, CZECH REPUBLIC: ELSEVIER SCIENCE INC.
2012 Hodge, G., Hodge, S., Holmes-Liew, C. -L., Reynolds, P. N., & Holmes, M. (2012). Down-Regulation of CD28 and Up-Regulation of 4-1BB on Peripheral Blood Pro-Inflammatory CD8+T Cells Is Associated with BOS. Poster session presented at the meeting of JOURNAL OF HEART AND LUNG TRANSPLANTATION. Prague, CZECH REPUBLIC: ELSEVIER SCIENCE INC.
2012 Mukaro, V., Hodge, G., Holmes, M., Reynolds, P., & Hodge, S. (2012). ENHANCED CYTOTOXIC FUNCTION OF NK AND NKT-LIKE CELLS ASSOCIATED WITH DECREASED CD94 IN THE AIRWAY IN COPD. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2012 Hodge, G., Hodge, S., Holmes-Liew, C. -L., Reynolds, P. N., & Holmes, M. (2012). DOWNREGULATION OF CD28 AND UPREGULATION OF 4-1BB ON PERIPHERAL BLOOD PRO-INFLAMMATORY CD8+T CELLS IS ASSOCIATED WITH BOS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2012 Garside, C. G., Simpson, J. L., Yang, I. A., Reynolds, P. N., Hodge, S. J., James, A. L., . . . Gibson, P. G. (2012). INFLAMMATORY SUBTYPES OF UNCONTROLLED ASTHMA IN AUSTRALIA. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2012 Ahern, J., Hodge, G., Jersmann, H., Holmes, M., Reynolds, P. N., Upham, J., & Hodge, S. (2012). SOLUBLE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS IS DECREASED IN HEALTHY SMOKERS AND CURRENT SMOKER COPD SUBJECTS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2012 Hodge, G., Hodge, S., Ahern, J., Holmes-Liew, C. -L., Reynolds, P., & Holmes, M. (2012). BOS IS ASSOCIATED WITH AN INCREASE IN GRANZYMES/PERFORIN AND PRO-INFLAMMATORY CYTOKINES BY PERIPHERAL BLOOD NK CELLS. Poster session presented at the meeting of RESPIROLOGY. WILEY-BLACKWELL. 2009 Hodge, S., Matthews, G. M., Ahern, J., Djukic, M., Hodge, G., Jersmann, H., . . . Reynolds, P. N. (2009). Is There a Therapeutic Role for Mannose Binding Lectin in Cigarette Smoke-Induced Lung Inflammation? Evidence from a Murine Model.. Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. AMER THORACIC SOC.
Grants & Funding
Total funding for career $15,980,192 [$750,500.00 relinquished]
Current Funding: NHMRC
2018-2021 | NHMRC PROJECT GRANT | Role for zinc and ZIP2 in the action of nitric oxide and in vascular protection against cigarette smoke and cardiovascular disease. | Zalewski P, Hodge S, Beltrame J, Murgia C, Tavella R. | $660,940.60 |
2013-2016 | NHMRC CAREER DEVELOPMENT FELLOWSHIP R.D. Wright Biomedical CDF Level 2 APP1045511 | Investigating the causes of failed efferocytosis in COPD/emphysema with a view to identifying novel therapeutic targets. | Hodge S | $439,920 |
2016-2018 | NHMRC PROJECT GRANT | Exploiting increased autophagy in bronchial epithelial cells: a new therapeutic approach for chronic obstructive pulmonary disease (COPD). | Hodge S, Zalewski P, Roscioli E. | $724,161 |
2016-2018 | NHMRC PROJECT GRANT | Targeting the defective airway macrophage function in chronic obstructive pulmonary disease (COPD): a new therapeutic approach. | Hodge S, Reynolds PN. | $710,928 |
2016- | NHRMC PROJECT GRANT | Conquering the final frontier in lung transplantation - Mesenchymal stromal cell therapy for chronic lung allograft dysfunction. | Chambers D, Hopkins P, Glanville A, Westall G, Holmes M. Hodge S (AI) | $1,887,790. |
2014-2018 | NHMRC CRE APP1058550 | Phenotyping severe asthma for improved outcomes: a translational CRE. | Gibson, Marks, McDonald, Wark, Upham, Thien, James, Reddell, King, Smith, Hodge S (AI) | $2,499,750 |
2013-2016 | NHMRC Project Grant 1042601 | Protracted bacterial bronchitis: long term outcomes, systemic and airway predictors of recurrence | Chang A, Upham J, Gibson P, Yerkovich S, Baines K, Hodge S, Pizzutto S, Masters I, Buntain H. | $777,376.76 |
Current funding- non-NHMRC
2021-2022 | CF Foundatiopn | Hypoxia and Vascular dysfunction in cystic fibrosis. | Hodge S | $50,000 |
2020-2021 | WCH Foundation Research Grant. | Hypoxia and Vascular dysfunction in cystic fibrosis. | Hodge S, | $100,000 |
2020-2021 | Thoracic Society of Australia and New Zealand/ Vertex | Adult Cystic Fibrosis Research Award | Hodge S | $75,000 |
2017-2019 | The University of Adelaide | Beacon Research Fellowship | Hodge S | $574,689 |
2018 | Royal Adelaide Hospital | Near Miss Funding | Hodge S | $50,000 |
2018 | RAH Respiratory Clinical Trials Unit | Support for Transplant Research | Hodge G and Hodge S | $35,000 |
2017-2019 | Research Infrastructure Block Grants (RIBG) | Hodge S | $70,000 | |
2017 | RAH Respiratory Clinical Trials Unit | Support for Transplant Research | Hodge G and Hodge S | $30,859 |
2017 | RAH | Clinical Project Grant | Whittall J, Hodge S | $50,000 |
2017 | Thoracic Society of Australia and New Zealand | Rob Pierce Grant for Indigenous Health Research | Hodge S | $50,000 |
2017 | Thoracic Society of Australia and New Zealand / Boehringer | COPD Research Award | Hodge S and Hodge G | $30,000 |
2017 | Lung Foundation Australia/ A. Menarini Australia Pty. Ltd. | International Travel Grant | Hodge S | $50,000 |
2017 | Adelaide medical school | investment for success near miss funding | Zalewski P, Hodge S | $30,000 |
2016 | Channel 7 Children’s Research Foundation | Hodge S, Chang A, Upham J | $75,000 | |
2013-2019 | Royal Adelaide Hospital CCF Brine Bequest | Mannose binding lectin as a novel therapy to prevent COPD/emphysema in smokers. | Hodge S | $300,000 |
2016 | TSANZ and National Asthma Council Australia | Are e-cigarettes as harmless as sellers would have you believe? Investigating the effect of Vaping on macrophage function. | Ween M, Hodge S | $60,000 |
2016-2017 | Astra Zeneca/ Thoracic Society of Australia and New Zealand | Respiratory Research fellowship | Roscioli E, Hodge S (Supervisor) | $150000 |
2016 | RAH Clinical Project Grant | The role of autophagy in airway epithelial cells exposed to bush fire smoke | Roscioli E, Hodge S, Jersmann H. | $50,000 |
2016 | RAH Clinical Project Grant | Are e-cigarettes as harmless as sellers would have you believe? Investigating the effect of Vaping on macrophage function. | Ween M, Hodge S. | $50,000 |
2016 | Asthma Australia Travel Award for mid-career researchers | Tran H, Hodge S (supervisor) | $5000 | |
2016 | RIBG Funding | Hodge S. | $70,000 | |
2016 | RIBG Funding | Hodge G, Hodge S | $22,000 |
Previous funding: NHMRC
2013-2015 | National Health and Medical Research Council of Australia Project Grant 1045514 | Identification and therapeutic modulation of sphingolipids as novel lung macrophage-targeted treatments for COPD/emphysema | Hodge S, Haberberger R, Reynolds PN, Meech R. | $670,475.81 |
2010-2012 | National Health and Medical Research Council of Australia Project Grant 627223 | Alveolar macrophage zinc and zinc transporters and their role in phagocytosis | Zalewski P, Hodge S, Jersmann H. | $284,044.00 |
2010-2012 | National Health and Medical Research Council of Australia Project Grant 626972 | Modulation of macrophage function as a therapy for chronic obstructive pulmonary disease (COPD) | Hodge S, Reynolds P, Holmes M, Hodge G, Jersmann J. | $428,104.00 |
2009-2013 | National Health and Medical Research Council of Australia Project Grant 569246 | Asthma Macrolides Azithromycin Efficacy and Safety study. | PG Gibson, JL Simpson, J Upham, PR Reynolds, IA Yang, S Hodge, AL James. | $3,098,136.00 |
2009-2011 | National Health and Medical Research Council of Australia Project Grant 565210 | Surfactant protein D as a candidate therapy in COPD. | P Reynolds, S Hodge, H Clark. | $400,394.00 |
2008-2011 | National Health and Medical Research Council of Australia Biomedical Career Development Award 508134 | Investigating the causes of failed efferocytosis in COPD/emphysema with a view to identifying novel therapeutic targets. | S Hodge | $375,250.00 |
2008-2010 | National Health and Medical Research Council of Australia Project Grant 508121 | Monitoring of leukocyte cytokine /chemokine molecules to improve morbidity in lung transplant patients. | PN Reynolds, MD Holmes, G Hodge, S Hodge, D Chambers. | $371,604.00 |
2005-2007 | National Health and Medical Research Council of Australia Project Grant 349337 | The Role of Apoptosis and Macrophage Function in Chronic Obstructive Pulmonary Disease | P N. Reynolds, MD. Holmes, G Hodge, S Hodge | $463,400.00 |
2008-2011 | National Health and Medical Research Council of Australia Clinical Career Development Award 508135 Relinquished for Biomedical Career Development Award. | Investigating the causes of failed efferocytosis in COPD/emphysema with a view to identifying novel therapeutic targets. | Sandra Hodge | $370,000.00 |
2008-2011 | National Health and Medical Research Council of Australia Biomedical Career Development Award 508135 | Investigating the causes of failed efferocytosis in COPD/emphysema with a view to identifying novel therapeutic targets. | Sandra Hodge | $370,000.00 |
Previous funding- non NHMRC
2016 RAH Respiratory Clinical Trials Unit Support for Transplant Research $66,931 Hodge S and Hodge G
2016 Asthma Australia Travel Award for mid-career researchers Tran H, Hodge S (supervisor) $5000
2016 RAH Clinical Project Grant. Better understanding and treating the defect in airway macrophage phagocytosis of potentially pathogenic bacteria in chronic obstructive pulmonary disease (COPD). Whittall J, Hodge S $50,000
2016 Thoracic Society of Australia and New Zealand Robert Pierce Grant-in-Aid for Indigenous Lung Health. Hodge S $15,000
2016 Research Infrastructure Block Grants (RIBG). FACSCanto II Flow Cytometer Maintenance and Calibration Hodge S, Hodge G 70,000
2016 Research Infrastructure Block Grants (RIBG) Hodge G, Hodge S $40,000
2015 | RIBG Funding | Hodge G, Hodge S | $22,000 |
2015 | Asthma Australia Travel Award for mid-career researchers | Hodge S | $5000 |
2014 | RAH Clinical Project Grant | Hodge G, Hodge S | $35,000 |
2013-14 | Lung Foundation Australia/ Boehringer Ingelheim COPD Research Fellowship | $160,000 | |
2014 | Menarini | Hodge G, Hodge S | $20,000 |
2013 | Thoracic Society of Australia and New Zealand Robert Pierce Grant-in-Aid for Indigenous Lung Health. | Hodge S | $15,000 |
2013-2014 | Channel 7 Children’s Research Foundation APP13688 Adaptive and innate immunity in children with bronchiectasis. | Chang A, Hodge S, Yerkovich S, Pizzutto S. | $75,000 |
2012 | Royal Adelaide Hospital Clinical Research Grant. Reducing steroid resistance by targeting P-gp1 on pro-inflammatory T-cell subsets to reduce inflammation in COPD | Hodge G, Hodge S | $45,000 |
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Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2018 - 2022 Principal Supervisor An investigation of the Rubicon/LC3 associated phagocytosis (LAP) dysregulation as a therapeutic target in chronic obstructive pulmonary diseases (COPD) and in response to cigarette smoke exposure Doctor of Philosophy Doctorate Full Time Dr Patrick Fordjour Asare 2011 - 2015 Principal Supervisor Genetic and Epigenetic Characterization of the Sphingosine-1-Phosphate Signalling System in Macrophages in Chronic Obstructive Pulmonary Disease Doctor of Philosophy Doctorate Full Time Mr Jameel Barnawi 2004 - 2008 Co-Supervisor Characterisation of Markers Associated with Systemic Inflammation in Children with Chronic Kidney Disease Doctor of Philosophy Doctorate Part Time APrf Judith Nairn -
Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2021 - 2021 Principal Supervisor Neutrophil Endothelin-1 Signalling in Cystic Fibrosis - Potential Role in Development of Pulmonary Hypertension and its Therapeutic Modulation The University of Adelaide Masters of Biotechnology Master Full Time Sindhuja Nallari; 2018 - ongoing Principal Supervisor Mechanistic and therapeutic studies of impaired phagocytic removal and xenophagic degradation of airway bacteria in COPD The University of Adelaide Doctorate Patrick Asare 2018 - ongoing Principal Supervisor Assessing the role of SIRT-1 in airway macrophage dysfunction in COPD (and its association with the sphingosine-1-phosphate pathway) The University of Adelaide Honours Full Time Alarmelu Ram 2018 - 2018 Principal Supervisor Investigating the capacity of azithromycin treatment to upregulate SIRT-1 expression and negate the airway macrophage dysfunction in COPD The University of Adelaide MBBS Elective Other Full Time Charles Jones 2017 - ongoing Other Create Communicate Connect Program The University of Adelaide Create Communicate Connect Program Other n/a 2016 - 2017 Principal Supervisor the immune molecule CD1b, and its potential role in the pathogenesis of COPD. The University of Adelaide Honours Full Time Charles Jones 2011 - 2011 External Supervisor Expression profile of the sphingosine kinase signalling system in the lung of patients with chronic obstructive pulmonary disease Flinders University Honours Full Time Fabian Cordts 2010 - 2010 Principal Supervisor Cytotoxic T-cell -mediated immune responses in patients with lung cancer and chronic obstructive pulmonary disease (COPD): implications for immune evasion by cancer cells The University of Adelaide Honours Full Time Cyd Soriano
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Board Memberships
Date Role Board name Institution name Country 2017 - ongoing Director The Thoracic Society of Australia and New Zealand Limited The Thoracic Society of Australia and New Zealand Australia 2017 - ongoing Director Board of the Thoracic Society of Australia and New Zealand Limited -
Committee Memberships
Date Role Committee Institution Country 2015 - ongoing Member CAHLN RRC Clinical Project Grant Committee 2015 - ongoing Member RAH Research Foundation Research Infrastructure Block Grants Committee 2015 - ongoing Chair TSANZ Cell Biology and Immunology SIG 2015 - ongoing Chair Research Committee Awards Sub-committee, TSANZ 2013 - ongoing Member TSANZ Research sub-committee 2013 - ongoing Member SA Pathology/ Hanson Institute Research equipment Advisory Committee 2013 - 2016 Member TSANZ Research sub-committee 2012 - ongoing Member Education and Research-subcommittee Thoracic Society of ANZ 2012 - 2016 Member NHMRC GRP -
Memberships
Date Role Membership Country 2015 - ongoing Asia Pacific Society of Respirology 2012 - ongoing International Society for Heart and Lung Transplantation 2012 - ongoing European Respiratory Society 2012 - ongoing American Thoracic Society 2010 - ongoing Australian Lung Foundation 2005 - ongoing Thoracic Society of Australia and New Zealand -
Consulting/Advisories
Date Institution Department Organisation Type Country 2017 - ongoing Thoracic Society of Australia and New Zealand Australia 2017 - ongoing Thoracic Society of Australia and New Zealand and the Lung Foundation Australia Australia -
Offices Held
Date Office Name Institution Country 2017 - ongoing Deputy Treasurer The Thoracic Society of Australia and New Zealand Australia 2017 - ongoing Finance and Risk Assessment Committee The Thoracic Society of Australia and New Zealand Australia 2017 - ongoing Co-chair Research Committee The Thoracic Society of Australia and New Zealand Australia
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