South Australian Immunogenomics Cancer Institute
Faculty of Health and Medical Sciences
Dr Sandii Constable is the Research Manager for Professor Jose Polo laboratory as part of the Adelaide Centre of Epigenetics (ACE) and the South Australian Immunogenetics Cancer Institute (SAiGENCI). Dr Constable received her PhD from the University of Georgia in 2014. Her doctoral research was undertaken in the laboratory of Professor Lance Wells located in the Complex Carbohydrate Research Center, and focused on a simple glycosylation addition to embryonic stem cell transcription factor proteins responsible for the maintenance of pluripotency. After the completion of her PhD, Dr Constable underwent Postdoctoral training in ciliary signalling during mouse embryonic development at both Emory University under the supervision of Professor Tamara Caspary, and Associate Professor Saikat Mukhopahyay at UT Southwestern Medical Center. Dr Constable's interests lie in the cell signals and factors that promote correct development, differentiation and reprogramming of embryonic cells and embryos.
Date Position Institution name 2015 - 2016 Faculty of Biology Georgia Gwinnett College 2014 - 2016 Instructor of Biology University of Georgia 2003 - 2014 Research Associate ViaCyte (United States) 2001 - 2003 Research Assistant BresaGen Pty Ltd
Date Institution name Country Title 2007 - 2014 University of Georgia United States PhD 1995 - 1999 University of Adelaide Australia B.Sc
Date Title Institution Country 2019 - 2021 Postdoctoral Fellow University of Texas Southwestern Medical Center United States 2016 - 2019 Postdoctoral Fellow Emory University United States
Year Citation 2020 Constable, S., Long, A. B., Floyd, K. A., Schurmans, S., & Caspary, T. (2020). The ciliary phosphatidylinositol phosphatase Inpp5e plays positive and negative regulatory roles in Shh signaling. Development (Cambridge), 147(3), 13 pages.
DOI Scopus10 WoS10 Europe PMC10
2020 Constable, S., & Mukhopadhyay, S. (2020). Ubiquitin Tunes Hedgehog in Matters of the Heart.. Developmental cell, 55(4), 385-386.
2019 Guo, J., Otis, J. M., Suciu, S. K., Catalano, C., Xing, L., Constable, S., . . . Anton, E. S. (2019). Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models. Developmental Cell, 51(6), 759-774.e5.
DOI Scopus30 WoS28 Europe PMC17
2019 Ferent, J., Constable, S., Gigante, E. D., Yam, P. T., Mariani, L. E., Legué, E., . . . Charron, F. (2019). The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance. Cell Reports, 29(11), 3356-3366.e3.
DOI Scopus16 WoS18 Europe PMC11
2017 Constable, S., Lim, J. M., Vaidyanathan, K., & Wells, L. (2017). O-GlcNAc transferase regulates transcriptional activity of human Oct4. Glycobiology, 27(10), 927-937.
DOI Scopus23 WoS22 Europe PMC18
2010 Brimble, S., Wollaston-Hayden, E. E., Teo, C. F., Morris, A. C., & Wells, L. (2010). The role of the O-GlcNAc modification in regulating eukaryotic gene expression. Current Signal Transduction Therapy, 5(1), 12-24.
DOI Scopus19 WoS16 Europe PMC9
2007 Schulz, T. C., Swistowska, A. M., Liu, Y., Swistowski, A., Palmarini, G., Brimble, S. N., . . . Zeng, X. (2007). A large-scale proteomic analysis of human embryonic stem cells. BMC Genomics, 8(1), 16 pages.
DOI Scopus27 WoS20 Europe PMC18
2007 Brimble, S. N., Sherrer, E. S., Uhl, E. W., Wang, E., Kelly, S., Merrill, A. H., . . . Schulz, T. C. (2007). The cell surface glycosphingolipids SSEA-3 and SSEA-4 are not essential for human ESC pluripotency. Stem Cells, 25(1), 54-62.
DOI Scopus89 WoS81 Europe PMC63
2007 Wang, L., Schulz, T. C., Sherrer, E. S., Dauphin, D. S., Shin, S., Nelson, A. M., . . . Robins, A. J. (2007). Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Blood, 110(12), 4111-4119.
DOI Scopus264 WoS233 Europe PMC196
2006 Plaia, T. W., Josephson, R., Liu, Y., Zeng, X., Ording, C., Toumadje, A., . . . Auerbach, J. M. (2006). Characterization of a new NIH-registered variant human embryonic stem cell line, BG01V: A tool for human embryonic stem cell research. Stem Cells, 24(3), 531-546.
DOI Scopus65 WoS57 Europe PMC46
2005 Bhattacharya, B., Cai, J., Luo, Y., Miura, T., Mejido, J., Brimble, S. N., . . . Puri, R. K. (2005). Comparison of the gene expression profile of undifferentiated human embryonic stem cell lines and differentiating embryoid bodies. BMC Developmental Biology, 5(1), 16 pages.
DOI Scopus99 WoS90 Europe PMC77
2005 Maitra, A., Arking, D. E., Shivapurkar, N., Ikeda, M., Stastny, V., Kassauei, K., . . . Chakravarti, A. (2005). Genomic alterations in cultured human embryonic stem cells. Nature Genetics, 37(10), 1099-1103.
DOI Scopus532 WoS457 Europe PMC353
2004 Brimble, S. N., Zeng, X., Weiler, D. A., Luo, Y., Liu, Y., Lyons, I. G., . . . Schulz, T. C. (2004). Karyotypic stability, genotyping, differentiation, feeder-free maintenance, and gene expression sampling in three human embryonic stem cell lines derived prior to August 9, 2001. Stem Cells and Development, 13(6), 585-597.
DOI Scopus184 WoS160 Europe PMC126
Constable, S., Long, A. B., Floyd, K. A., Schurmans, S., & Caspary, T. (n.d.). Ciliary phosphatidylinositol phosphatase Inpp5e plays positive and negative regulatory roles in Shh signaling.
Year Citation 2022 Constable, S., White, K., Somatilaka, B. N., & Mukhopadhyay, S. (2022). Studying Hedgehog Signaling During Mouse Neural Tube Development. In Methods in Molecular Biology (Vol. 2374, pp. 59-71). Springer US.
In addition to mentoring students in the lab, Dr Constable has experience in teaching introductory and advanced biology classes to undergraduates.
2011-2016. Principles of Biology I (lectures and labs)
2014. Advanced Topics in Biology - “Biology of Stem Cells” (paper based discussion group)
Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2020 - 2021 Co-Supervisor Characterization of changes in cilia and centrioles during mouse cerebellum development UT Southwestern Medical Center Undergraduate Research Intern Other Part Time Amin Lim 2017 - 2019 Co-Supervisor Regulation of Sonic Hedgehog signalling in neural tube development Emory University Other Full Time Kathryn Floyd 2007 - 2008 Co-Supervisor Determining the Possibility of the Role of O-GlcNAc in Insulin Signaling Mutants – Under Stress Response University of Georgia CURO (Center for Undergraduate Research Opportunities) Other Part Time Wei Wang
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