Samantha Korver

Miss Samantha Korver

Higher Degree by Research Candidate

PhD Candidate

Adelaide Medical School

Faculty of Health and Medical Sciences


Samantha is a current PhD Candidate in the Cancer Treatment Toxicities Group within the Adelaide Medical School, Faculty of Health and Medical Sciences. Her research focus is identifying genetic predictors for severe gastrointestinal toxicity (GI) risk in patients following 5-fluorouracil (5-FU) chemotherapy treatment.

Samantha is supervised by Dr Janet Coller, Associate Professor Joanne Bowen and Professor Rachel Gibson.

Severe gastrointestinal (GI) toxicity is a common adverse effect following 5-fluorouracil (5-FU)-based chemotherapy treatment. The presence of severe GI toxicity leads to treatment revisions, sub-optimal therapy outcomes, and decreases to patients’ quality of life. There are no adequate predictors for 5-FU-induced severe GI toxicity risk. The Toll-like Receptor/Interleukin-1 (TIR) domain signaling pathway is known to be a mediating pathway in the development of GI toxicity. Hence, genetic variability in this signaling pathway may alter the pathophysiology of GI toxicity and therefore, be predictive of risk.

I am investigating if genetic variants of this pathway influence the pathophysiology and development of GI toxicity and, if they can be used as diagnostic markers of toxicity risk. Identifying a patient diagnostic marker for GI toxicity risk will allow patients at high risk of severe toxicity to be identified prior to 5-FU treatment. This will enable their supportive care measures to be personalised and their treatment to be stringently monitored to decrease their risk of developing severe toxicity. This will not only improve their treatment outcomes but also improve their quality of life. 

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  • Journals

    Year Citation
    2019 Korver, S. K., Gibson, R. J., Bowen, J. M., & Coller, J. K. (2019). Toll-like receptor/interleukin-1 domain innate immune signalling pathway genetic variants are candidate predictors for severe gastrointestinal toxicity risk following 5-fluorouracil-based chemotherapy.. Cancer Chemotherapy and Pharmacology, 83(2), 217-236.
    DOI
  • Conference Papers

    Year Citation
    2018 Korver, S. K., Bowen, J. M., Ball, I. A., Gibson, R. J., Tuke, J., Logan, R., . . . Coller, J. K. (2018). Personalised supportive care for patients receiving 5-fluorouracil (5-FU): analysis of multivariate SNP risk prediction for GI toxicity. In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 14 (pp. 58-59). WILEY.
  • Conference Items

    Year Citation
    2017 Korver, S. K., Ball, I. A., Gibson, R. J., Logan, R. M., Karapetis, C. S., Keefe, D. M., . . . Coller, J. K. (2017). The Effect of Immune Genetic Variants on Chemotherapy-Induced Gastrointestinal Toxicity (CIGT) Risk in Patients Receiving 5-Fluorouracil. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY.
    2017 Korver, S. K., Ball, I. A., Gibson, R. J., Tuke, J., Logan, R. M., Richards, A., . . . Coller, J. K. (2017). Interleukin-1 Beta (IL1B) Genetic Variability is Predictive of Chemotherapy-Induced Gastrointestinal Toxicity (CIGT) Risk in Patients Receiving 5-Fluorouracil. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY.

2018: Cancer Council SA Beat Cancer Project Travel Grant

2018: Walter and Dorothy Duncan Trust Grant

2018: Adelaide Medical School Research Travel Award

2017: Doctor Chun Chung Wong and Madam So Sau Lam Memorial Postgraduate Cancer Research Scholarship

2016: Research Training Program Scholarship 

Health and Medical Sciences

Project Supervisor, Investigative Cell Biology

Practical Demonstrator, Physiology IIA & IIB

Nursing

Lecturer, Biology for Nursing Practice

Tutor, Biology for Nursing Practice

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  • Committee Memberships

    Date Role Committee Institution Country
    2016 - 2018 Treasurer Australian Society for Medical Research (ASMR) - SA Chapter ASMR Australia
  • Memberships

    Date Role Membership Country
    2018 - ongoing Member Clinical Oncology Society of Australia (CoSA) Australia
    2018 - ongoing Member Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Australia
    2015 - ongoing Member Multinational Association of Supportive Care in Cancer (MASCC) Canada
    2015 - ongoing Member Australian Society for Medical Research (ASMR) Australia
  • Position: PhD Candidate
  • Phone: 83131537
  • Email: samantha.korver@adelaide.edu.au
  • Campus: North Terrace
  • Building: Helen Mayo South, floor 2
  • Org Unit: Faculty of Health and Medical Sciences

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