Higher Degree by Research Candidate
Adelaide Medical School
Faculty of Health and Medical Sciences
Samantha is a current PhD Candidate in the Cancer Treatment Toxicities Group within the Adelaide Medical School, Faculty of Health and Medical Sciences. Her research focus is identifying genetic predictors for severe gastrointestinal toxicity (GI) risk in patients following 5-fluorouracil (5-FU) chemotherapy treatment.
Samantha is supervised by Dr Janet Coller, Associate Professor Joanne Bowen and Professor Rachel Gibson.
Severe gastrointestinal (GI) toxicity is a common adverse effect following 5-fluorouracil (5-FU)-based chemotherapy treatment. The presence of severe GI toxicity leads to treatment revisions, sub-optimal therapy outcomes, and decreases to patients’ quality of life. There are no adequate predictors for 5-FU-induced severe GI toxicity risk. The Toll-like Receptor/Interleukin-1 (TIR) domain signaling pathway is known to be a mediating pathway in the development of GI toxicity. Hence, genetic variability in this signaling pathway may alter the pathophysiology of GI toxicity and therefore, be predictive of risk.
I am investigating if genetic variants of this pathway influence the pathophysiology and development of GI toxicity and, if they can be used as diagnostic markers of toxicity risk. Identifying a patient diagnostic marker for GI toxicity risk will allow patients at high risk of severe toxicity to be identified prior to 5-FU treatment. This will enable their supportive care measures to be personalised and their treatment to be stringently monitored to decrease their risk of developing severe toxicity. This will not only improve their treatment outcomes but also improve their quality of life.
Date Institution name Country Title 2015 - 2015 The University of Adelaide Australia B.HlthSc (Honours) 2012 - 2014 The University of Adelaide Australia B.Sc (Biomedical)
Date Title Institution Country 2016 - 2019 Career and Research Skills Training (CaRST) The University of Adelaide Australia 2016 - 2019 PhD in Medicine The University of Adelaide Australia
Year Citation 2019 Korver, S. K., Gibson, R. J., Bowen, J. M., & Coller, J. K. (2019). Toll-like receptor/interleukin-1 domain innate immune signalling pathway genetic variants are candidate predictors for severe gastrointestinal toxicity risk following 5-fluorouracil-based chemotherapy.. Cancer Chemotherapy and Pharmacology, 83(2), 217-236.
Year Citation 2018 Korver, S. K., Bowen, J. M., Ball, I. A., Gibson, R. J., Tuke, J., Logan, R., . . . Coller, J. K. (2018). Personalised supportive care for patients receiving 5-fluorouracil (5-FU): analysis of multivariate SNP risk prediction for GI toxicity. In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 14 (pp. 58-59). WILEY.
Year Citation 2017 Korver, S. K., Ball, I. A., Gibson, R. J., Logan, R. M., Karapetis, C. S., Keefe, D. M., . . . Coller, J. K. (2017). The Effect of Immune Genetic Variants on Chemotherapy-Induced Gastrointestinal Toxicity (CIGT) Risk in Patients Receiving 5-Fluorouracil. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY. 2017 Korver, S. K., Ball, I. A., Gibson, R. J., Tuke, J., Logan, R. M., Richards, A., . . . Coller, J. K. (2017). Interleukin-1 Beta (IL1B) Genetic Variability is Predictive of Chemotherapy-Induced Gastrointestinal Toxicity (CIGT) Risk in Patients Receiving 5-Fluorouracil. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY.
2018: Cancer Council SA Beat Cancer Project Travel Grant
2018: Walter and Dorothy Duncan Trust Grant
2018: Adelaide Medical School Research Travel Award
2017: Doctor Chun Chung Wong and Madam So Sau Lam Memorial Postgraduate Cancer Research Scholarship
2016: Research Training Program Scholarship
Health and Medical Sciences
Project Supervisor, Investigative Cell Biology
Practical Demonstrator, Physiology IIA & IIB
Lecturer, Biology for Nursing Practice
Tutor, Biology for Nursing Practice
Date Role Committee Institution Country 2016 - 2018 Treasurer Australian Society for Medical Research (ASMR) - SA Chapter ASMR Australia
Date Role Membership Country 2018 - ongoing Member Clinical Oncology Society of Australia (CoSA) Australia 2018 - ongoing Member Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Australia 2015 - ongoing Member Multinational Association of Supportive Care in Cancer (MASCC) Canada 2015 - ongoing Member Australian Society for Medical Research (ASMR) Australia
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