Saif Islam

Dr Saif Islam

School of Pharmacy and Biomedical Science

College of Health


Dr. Islam is a distinguished scientist with over 16 years of experience specialising in medicine development, evaluation and regulatory compliance, working across both industry and academia. His career has been marked by a deep commitment to advancing medicine discovery and translational research, particularly in cancer therapies.
Dr. Islam holds a PhD in Medical Science and a Bachelor of Medical and Pharmaceutical Sciences (Honours) from the University of South Australia, along with a Master of Science and a Bachelor of Science (Honours) in Microbiology from the University of Dhaka. His strong academic foundation, combined with his expertise in medicine regulation has positioned him as an emerging leader in his field.
Before transitioning to academia, Dr. Islam spent seven years in the quality department of Beximco Pharmaceuticals, a TGA Australia and US-FDA accredited company. As an Assistant Manager and section head in Microbiology, he played a pivotal role in securing TGA accreditation for the company. His industry experience provided him with valuable insights into the challenges of ensuring quality in large-scale pharmaceutical operations. In his academic career, Dr. Islam has made significant contributions to cancer research. As a key member of a multidisciplinary medicine discovery and development team, he worked on several new drug candidates, two of which (Auceliciclib and Sunaciclib) have reached clinical trials, while others are in late-stage preclinical development.
Dr. Islam’s research interests focus on developing innovative targeted cancer therapies through a multidisciplinary approach. His collaborations span national and international institutions, working closely with both industry and academic researchers. His research has been guided by Professor Shudong Wang and Professor Richard Head, whose extensive translational research and commercialization success have been instrumental in shaping Dr. Islam’s work. Together, their efforts have led to partnerships with world-class research teams in Austria, Australia, China, Germany, the UK, and the USA.
With over 20 peer-reviewed publications, a patent, and numerous prestigious awards, Dr. Islam continues to drive innovation in medicine discovery and development. His goal remains to translate cutting-edge research into clinical solutions that improve patient outcomes, making a lasting impact on cancer therapeutics.

Year Citation
2025 Head, R., Islam, S., & Martin, J. H. (2025). A unified explanation for drug repurposing and pharmacological pleiotropy based on classical and statistical thermodynamics. Pharmacology Research & Perspectives, 13(4, article no. e70158), 1-11.
DOI
2025 Head, R., Islam, S., & Martin, J. H. (2025). Approaches to repurposing reverse transcriptase antivirals in cancer. British Journal of Clinical Pharmacology, online(9), 1-13.
DOI Scopus1 WoS1 Europe PMC1
2024 Matthews, B., Wong Brown, M., Liu, D., Yee, C., Dickson, K. A., Schneider, J., . . . Bowden, N. A. (2024). Drug repurposing screen targeting PARP identifies cytotoxic activity of efavirenz in high-grade serous ovarian cancer. Molecular Therapy Oncology, 32(4, article no. 200911), 1-15.
DOI Scopus3 WoS2 Europe PMC1
2024 Rahman, R., Rahaman, M. H., Hanson, A. R., Choo, N., Hassankhani, R., Islam, S., . . . Selth, L. A. (2024). CDK9 inhibition inhibits multiple oncogenic transcriptional and epigenetic pathways in prostate cancer. British Journal of Cancer, 131(6), 1092-1105.
DOI Scopus3 WoS4 Europe PMC5
2022 Islam, S., Teo, T., Kumarasiri, M., Slater, M., Martin, J. H., Wang, S., & Head, R. (2022). Combined In Silico and In Vitro Evidence Supporting an Aurora A Kinase Inhibitory Role of the Anti-Viral Drug Rilpivirine and an Anti-Proliferative Influence on Cancer Cells. Pharmaceuticals, 15(10), 16 pages.
DOI Scopus6 WoS6 Europe PMC6
2022 Head, R. J., Lumbers, E. R., Jarrott, B., Tretter, F., Smith, G., Pringle, K. G., . . . Martin, J. H. (2022). Systems analysis shows that thermodynamic physiological and pharmacological fundamentals drive COVID-19 and response to treatment. Pharmacology Research & Perspectives, 10(1, article no. e00922), 1-22.
DOI Scopus31 WoS27 Europe PMC16
2019 Abdelaziz, A. M., Diab, S., Islam, S., KC Basnet, S., Noll, B., Li, P., . . . Wang, S. (2019). Discovery of n-phenyl-4-(1h-pyrrol-3-yl)pyrimidin-2-amine derivatives as potent mnk2 inhibitors: design, synthesis, sar analysis, and evaluation of in vitro anti-leukaemic activity. Medicinal chemistry, 15(6), 600-621.
DOI Scopus6 WoS5 Europe PMC5
2018 Tadesse, S., Bantie, L., Tomusange, K., Yu, M., Islam, S., Bykovska, N., . . . Wang, S. (2018). Discovery and pharmacological characterisation of a novel series of highly selective inhibitors of cyclin-dependent kinases 4 and 6 as anticancer agents. British journal of pharmacology, 175(12), 2399-2413.
DOI Scopus23 WoS22 Europe PMC18
2017 Tadesse, S., Yu, M., Mekonnen, L. B., Lam, F., Islam, S., Tomusange, K., . . . Wang, S. (2017). Highly potent, selective, and orally bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine cyclin-dependent kinases 4 and 6 inhibitors as anticancer drug candidates: design, synthesis, and evaluation. Journal of medicinal chemistry, 60(5), 1892-1915.
DOI Scopus72 WoS65 Europe PMC40
2016 Li, P., Diab, S., Yu, M., Adams, J., Islam, S., Basnet, S. K. C., . . . Wang, S. (2016). Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells. Oncotarget, 7(35), 1-15.
DOI Scopus23 WoS23 Europe PMC22
2016 Long, Y., Yu, M., Li, P., Islam, S., Goh, A. W., Kumarasiri, M., & Wang, S. (2016). Synthesis and biological evaluation of heteroaryl styryl sulfone derivatives as anticancer agents. Bioorganic & medicinal chemistry letters, 26(23), 5674-5678.
DOI Scopus16 WoS16 Europe PMC7

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